Abstract: After brain ischaemia there is a flow of calcium into neurons mediated by NMDA receptors. The activation of these receptors and the resulting calcium overload are well known triggers of neuronal death in animal models of stroke and seizures. Researchers now propose that other pore-like proteins, the acid-sensing ion channels (ASICs), have an important role in the pathway between ischaemic injury and neuronal death. “The role of ASICs in the human brain is still enigmatic so any evidence on their inter-relationship with other mechanisms of already obvious importance (like NMDA receptors) is extremely valuable”, comments Oleg Krishtal (Bogomoletz Institute of Physiology, Ukraine).
Publication Year: 2005
Publication Date: 2005-12-20
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 1
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