Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2131564843', 'doi': 'https://doi.org/10.1002/jmv.2134', 'title': 'In vitro antiviral activity of dermaseptins against herpes simplex virus type 1*', 'display_name': 'In vitro antiviral activity of dermaseptins against herpes simplex virus type 1*', 'publication_year': 2001, 'publication_date': '2001-12-13', 'ids': {'openalex': 'https://openalex.org/W2131564843', 'doi': 'https://doi.org/10.1002/jmv.2134', 'mag': '2131564843', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11782932'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jmv.2134', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S49828768', 'display_name': 'Journal of Medical Virology', 'issn_l': '0146-6615', 'issn': ['0146-6615', '1096-9071'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5012233966', 'display_name': 'Afifa Belaïd', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I8636806', 'display_name': 'University of Sousse', 'ror': 'https://ror.org/00dmpgj58', 'country_code': 'TN', 'type': 'education', 'lineage': ['https://openalex.org/I8636806']}], 'countries': ['TN'], 'is_corresponding': False, 'raw_author_name': 'A. Belaid', 'raw_affiliation_strings': ['Laboratory of Biochemistry, Faculty of Medicine, Sousse, Tunisia.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Biochemistry, Faculty of Medicine, Sousse, Tunisia.', 'institution_ids': ['https://openalex.org/I8636806']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028442182', 'display_name': 'Mahjoub Aouni', 'orcid': 'https://orcid.org/0000-0001-8519-3611'}, 'institutions': [{'id': 'https://openalex.org/I166928557', 'display_name': 'University of Monastir', 'ror': 'https://ror.org/00nhtcg76', 'country_code': 'TN', 'type': 'education', 'lineage': ['https://openalex.org/I166928557']}], 'countries': ['TN'], 'is_corresponding': False, 'raw_author_name': 'M. Aouni', 'raw_affiliation_strings': ['Laboratory of Microbiology, Faculty of Pharmacy, Monastir, Tunisia'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Microbiology, Faculty of Pharmacy, Monastir, Tunisia', 'institution_ids': ['https://openalex.org/I166928557']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034911466', 'display_name': 'Ridha Khélifa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210124633', 'display_name': 'Habib hospital Thameur', 'ror': 'https://ror.org/0393ghj09', 'country_code': 'TN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210124633']}], 'countries': ['TN'], 'is_corresponding': False, 'raw_author_name': 'R. Khelifa', 'raw_affiliation_strings': ['Unit of Virology, Laboratory Services, Habib Thameur Hospital, Tunis, Tunisia'], 'affiliations': [{'raw_affiliation_string': 'Unit of Virology, Laboratory Services, Habib Thameur Hospital, Tunis, Tunisia', 'institution_ids': ['https://openalex.org/I4210124633']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083331338', 'display_name': 'A. Ben Slama', 'orcid': 'https://orcid.org/0000-0002-7592-465X'}, 'institutions': [{'id': 'https://openalex.org/I166928557', 'display_name': 'University of Monastir', 'ror': 'https://ror.org/00nhtcg76', 'country_code': 'TN', 'type': 'education', 'lineage': ['https://openalex.org/I166928557']}], 'countries': ['TN'], 'is_corresponding': False, 'raw_author_name': 'A. Trabelsi', 'raw_affiliation_strings': ['Laboratory of Microbiology, Faculty of Pharmacy, Monastir, Tunisia'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Microbiology, Faculty of Pharmacy, Monastir, Tunisia', 'institution_ids': ['https://openalex.org/I166928557']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004855834', 'display_name': 'M. Jemmali', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I8636806', 'display_name': 'University of Sousse', 'ror': 'https://ror.org/00dmpgj58', 'country_code': 'TN', 'type': 'education', 'lineage': ['https://openalex.org/I8636806']}], 'countries': ['TN'], 'is_corresponding': False, 'raw_author_name': 'M. Jemmali', 'raw_affiliation_strings': ['Laboratory of Biochemistry, Faculty of Medicine, Sousse, Tunisia.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Biochemistry, Faculty of Medicine, Sousse, Tunisia.', 'institution_ids': ['https://openalex.org/I8636806']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5066441154', 'display_name': 'Khaled Hani', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I8636806', 'display_name': 'University of Sousse', 'ror': 'https://ror.org/00dmpgj58', 'country_code': 'TN', 'type': 'education', 'lineage': ['https://openalex.org/I8636806']}], 'countries': ['TN'], 'is_corresponding': False, 'raw_author_name': 'K. Hani', 'raw_affiliation_strings': ['Laboratory of Biochemistry, Faculty of Medicine, Sousse, Tunisia.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Biochemistry, Faculty of Medicine, Sousse, Tunisia.', 'institution_ids': ['https://openalex.org/I8636806']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4020, 'currency': 'USD', 'value_usd': 4020, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.577, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 120, 'citation_normalized_percentile': {'value': 0.9591, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '66', 'issue': '2', 'first_page': '229', 'last_page': '234'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11103', 'display_name': 'Antimicrobial Peptides in Host Defense and Therapy', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2404', 'display_name': 'Microbiology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11103', 'display_name': 'Antimicrobial Peptides in Host Defense and Therapy', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2404', 'display_name': 'Microbiology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11966', 'display_name': 'Biomedical Applications of Silk Biomaterials', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/2502', 'display_name': 'Biomaterials'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T13326', 'display_name': 'Cyclotide Bioengineering and Protein Anchoring Mechanisms', 'score': 0.9935, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cytopathic-effect', 'display_name': 'Cytopathic effect', 'score': 0.6344042}, {'id': 'https://openalex.org/keywords/immunofluorescence', 'display_name': 'Immunofluorescence', 'score': 0.48496532}, {'id': 'https://openalex.org/keywords/antimicrobial-peptides', 'display_name': 'Antimicrobial Peptides', 'score': 0.450895}], 'concepts': [{'id': 'https://openalex.org/C2781196997', 'wikidata': 'https://www.wikidata.org/wiki/Q655331', 'display_name': 'Herpes simplex virus', 'level': 3, 'score': 0.83464485}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.71455413}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.6850518}, {'id': 'https://openalex.org/C2775996393', 'wikidata': 'https://www.wikidata.org/wiki/Q1149147', 'display_name': 'Cytopathic effect', 'level': 3, 'score': 0.6344042}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.5953138}, {'id': 'https://openalex.org/C2778236600', 'wikidata': 'https://www.wikidata.org/wiki/Q592324', 'display_name': 'Immunofluorescence', 'level': 3, 'score': 0.48496532}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.42280415}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.419703}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.40862194}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.24697918}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.09657431}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.062117428}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D029845', 'descriptor_name': 'Amphibian Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000890', 'descriptor_name': 'Anti-Infective Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D023181', 'descriptor_name': 'Antimicrobial Cationic Peptides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D006561', 'descriptor_name': 'Herpes Simplex', 'qualifier_ui': 'Q000821', 'qualifier_name': 'virology', 'is_major_topic': True}, {'descriptor_ui': 'D018259', 'descriptor_name': 'Herpesvirus 1, Human', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000212', 'descriptor_name': 'Acyclovir', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000212', 'descriptor_name': 'Acyclovir', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000890', 'descriptor_name': 'Anti-Infective Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000890', 'descriptor_name': 'Anti-Infective Agents', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D023181', 'descriptor_name': 'Antimicrobial Cationic Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023181', 'descriptor_name': 'Antimicrobial Cationic Peptides', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024882', 'descriptor_name': 'Drug Resistance, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006561', 'descriptor_name': 'Herpes Simplex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018259', 'descriptor_name': 'Herpesvirus 1, Human', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018259', 'descriptor_name': 'Herpesvirus 1, Human', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008826', 'descriptor_name': 'Microbial Sensitivity Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014779', 'descriptor_name': 'Virus Replication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014779', 'descriptor_name': 'Virus Replication', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jmv.2134', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S49828768', 'display_name': 'Journal of Medical Virology', 'issn_l': '0146-6615', 'issn': ['0146-6615', '1096-9071'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11782932', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.42}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 36, 'referenced_works': ['https://openalex.org/W1482180296', 'https://openalex.org/W1516223106', 'https://openalex.org/W1517335608', 'https://openalex.org/W1695142101', 'https://openalex.org/W1894360323', 'https://openalex.org/W1896164923', 'https://openalex.org/W1987386199', 'https://openalex.org/W1990467750', 'https://openalex.org/W1996835323', 'https://openalex.org/W1998206952', 'https://openalex.org/W2002816788', 'https://openalex.org/W2006821928', 'https://openalex.org/W2007807255', 'https://openalex.org/W2022446059', 'https://openalex.org/W2030324405', 'https://openalex.org/W2032714773', 'https://openalex.org/W2044368287', 'https://openalex.org/W2045360603', 'https://openalex.org/W2046221242', 'https://openalex.org/W2069990125', 'https://openalex.org/W2072933784', 'https://openalex.org/W2076110701', 'https://openalex.org/W2077208918', 'https://openalex.org/W2116114158', 'https://openalex.org/W2130703653', 'https://openalex.org/W2140303114', 'https://openalex.org/W2168519444', 'https://openalex.org/W2314645353', 'https://openalex.org/W2324486349', 'https://openalex.org/W2326554554', 'https://openalex.org/W2401705497', 'https://openalex.org/W2470329553', 'https://openalex.org/W2511208260', 'https://openalex.org/W4229497109', 'https://openalex.org/W4244732422', 'https://openalex.org/W4285719527'], 'related_works': ['https://openalex.org/W2412905892', 'https://openalex.org/W2373722203', 'https://openalex.org/W2362347319', 'https://openalex.org/W2350571353', 'https://openalex.org/W2074183682', 'https://openalex.org/W2063089078', 'https://openalex.org/W2018101352', 'https://openalex.org/W1998123828', 'https://openalex.org/W1993339219', 'https://openalex.org/W1562336285'], 'abstract_inverted_index': {'Abstract': [0], 'The': [1], 'in': [2, 46, 49], 'vitro': [3], 'antiviral': [4, 64, 77], 'activity': [5, 119], 'of': [6, 85, 87, 120, 130], 'dermaseptins': [7], '(S1–S5)': [8], 'against': [9, 66], 'herpes': [10], 'simplex': [11], 'virus': [12, 24, 47, 105, 109], 'type': [13], '1': [14], '(HSV1)': [15], 'was': [16, 123], 'investigated.': [17], 'These': [18], 'peptides': [19], 'were': [20, 35, 79], 'incubated': [21], 'with': [22], 'the': [23, 38, 62, 83, 104, 112, 118, 131, 138], 'and': [25, 32], 'its': [26, 97], 'target': [27, 113], 'cells': [28], 'under': [29], 'various': [30], 'conditions,': [31], 'their': [33], 'effects': [34], 'examined': [36], 'by': [37, 44, 56], 'cytopathic': [39], 'effect': [40, 65, 99], 'inhibition': [41], 'assay': [42], 'or': [43, 107], 'reduction': [45], 'yield': [48], 'Hep‐2': [50], 'cell': [51], 'cultures': [52], 'as': [53, 55, 74], 'well': [54], 'direct': [57], 'immunofluorescence.': [58], 'Dermaseptin': [59], 'S4': [60, 95], 'displayed': [61], 'strongest': [63], 'HSV1,': [67], 'at': [68, 125, 137], 'micromolar': [69], 'doses.': [70], 'Experiments': [71], 'including': [72], 'acyclovir': [73], 'a': [75, 126], 'reference': [76], 'agent': [78], 'performed': [80], 'to': [81, 92, 103, 111], 'investigate': [82], 'mode': [84], 'action': [86], 'this': [88, 121], 'dermaseptin.': [89], 'In': [90], 'contrast': [91], 'acyclovir,': [93], 'dermaseptin': [94, 122], 'showed': [96], 'inhibitory': [98], 'only': [100], 'when': [101], 'applied': [102], 'before,': [106], 'during': [108], 'adsorption': [110], 'cells.': [114], 'This': [115], 'suggested': [116], 'that': [117], 'exerted': [124], 'very': [127], 'early': [128], 'stage': [129], 'viral': [132], 'multiplication': [133], 'cycle,': [134], 'most': [135], 'likely': [136], 'virus‐cell': [139], 'interface.': [140], 'J.': [141], 'Med.': [142], 'Virol.': [143], '66:229–234,': [144], '2002.': [145], '©': [146], '2002': [147], 'Wiley‐Liss,': [148], 'Inc.': [149]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2131564843', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 12}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-09-19T20:27:10.130346', 'created_date': '2016-06-24'}