Title: Polymeric Core–Shell Assemblies Mediated by Host–Guest Interactions: Versatile Nanocarriers for Drug Delivery
Abstract: Angewandte Chemie International EditionVolume 48, Issue 5 p. 964-968 Communication Polymeric Core–Shell Assemblies Mediated by Host–Guest Interactions: Versatile Nanocarriers for Drug Delivery† Jianxiang Zhang Dr., Jianxiang Zhang Dr. Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109 (USA), Fax: (+1) 734-647-2110Search for more papers by this authorPeter X. Ma Prof., Peter X. Ma Prof. [email protected] Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109 (USA), Fax: (+1) 734-647-2110 Macromolecular Science and Engineering Center, Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 (USA)Search for more papers by this author Jianxiang Zhang Dr., Jianxiang Zhang Dr. Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109 (USA), Fax: (+1) 734-647-2110Search for more papers by this authorPeter X. Ma Prof., Peter X. Ma Prof. [email protected] Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109 (USA), Fax: (+1) 734-647-2110 Macromolecular Science and Engineering Center, Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 (USA)Search for more papers by this author First published: 13 January 2009 https://doi.org/10.1002/anie.200804135Citations: 134 † This work was funded by grants from the NIH (NIDCR DE015384 and DE017689, NIGMS GM075840). We gratefully acknowledge Prof. Kenichi Kuroda and Edmund Palermo (University of Michigan) for fluorescence measurements and Prof. Nicholas A. Kotov and Meghan Cuddihy (University of Michigan) for DLS measurements. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract First class delivery: Core–shell structured nanoassemblies could be constructed from a hydrophilic–hydrophilic block copolymer with one block containing β-cyclodextrin in the presence of hydrophobic guest compounds (see picture). The polymer can host various guest molecules, while the difference in sensitivity can be utilized to regulate release rate. By selecting appropriate guests, polyion complex (PIC) micelles could also be assembled. Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description anie_200804135_sm_miscellaneous_information.pdf4.5 MB miscellaneous information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume48, Issue5January 19, 2009Pages 964-968 RelatedInformation