Publication Information

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251, 500, 509, 554], 'glycoprotein': [10, 252, 501], '(VSG)': [11, 253, 502], 'gene': [12, 37, 254, 279, 643, 885, 1745, 1758, 1792, 1805, 1842, 1877, 1909, 1925, 1931, 2017, 2079, 2270, 2277, 2531, 3678, 3718, 3747], 'from': [13, 111, 255, 353, 645, 671, 1527, 1546, 1623, 2019, 2126, 2159, 2245, 2278, 2297, 2791, 2796, 3061, 3118, 3291, 3409, 3437, 3514, 3555, 3609, 3784], 'one': [14, 256, 1189], 'of': [15, 42, 65, 73, 92, 104, 116, 129, 192, 215, 232, 257, 284, 307, 315, 334, 346, 358, 371, 434, 457, 474, 647, 674, 676, 711, 972, 988, 1088, 1146, 1180, 1393, 1463, 1487, 1512, 1518, 1544, 1560, 1575, 1597, 1661, 1688, 1751, 1763, 1811, 1956, 2023, 2027, 2130, 2224, 2231, 2282, 2303, 2427, 2440, 2542, 2545, 2571, 2587, 2603, 2648, 2655, 2661, 2670, 2681, 2802, 2816, 2826, 3050, 3113, 3133, 3154, 3172, 3194, 3205, 3220, 3265, 3304, 3371, 3400, 3430, 3453, 3529, 3630, 3643, 3646, 3668, 3688, 3721, 3727, 3740, 3750, 3766, 3807, 3831, 3847, 3859, 3876, 3884, 3890, 3912, 3924, 3990, 3995, 4013, 4015, 4029, 4079, 4086, 4094, 4113, 4125, 4139, 4148, 4153, 4167, 4176, 4304, 4314, 4321, 4331, 4349, 4459, 4474, 4482, 4490, 4508, 4514, 4547], 'about': [16, 258, 648], '20': [17, 259, 649], 'VSG': [18, 260, 638, 651, 656, 666, 678, 721, 1690, 1701, 2102, 2133, 2166, 3524, 3532, 3549, 3558, 3652, 3686, 3724, 3754, 3769, 3787, 3834, 3861, 3928, 4018, 4169], 'expression': [19, 261, 520, 523, 528, 565, 568, 573, 652, 712, 1251, 3830], 'sites': [20, 262, 653, 1549, 2060], '(ESs).': [21, 263], 'In': [22, 125, 264, 367, 1019, 1316, 1436, 1515, 1682, 3295, 4183, 4368], 'order': [23, 265, 764, 1437, 1683, 3850, 4369], 'to': [24, 47, 266, 289, 718, 815, 817, 1056, 1101, 1261, 1288, 1326, 1329, 1369, 1438, 1468, 1684, 1712, 1833, 1900, 1935, 2261, 2551, 2558, 2581, 2599, 2651, 2677, 2701, 2768, 3097, 3121, 3439, 3464, 3534, 3605, 3664, 3680, 3762, 3798, 3851, 3888, 4092, 4287, 4370, 4422], 'study': [25, 267], 'ES': [26, 66, 268, 308, 670, 705, 745, 1001, 1024, 1172, 1182, 1190, 1195, 1286, 1405, 1443, 1488, 1702, 1714, 1754, 1766, 1797, 1810, 1845, 1864, 1882, 1912, 1917, 2154, 2167, 2240, 2306, 2499, 2536, 2608, 2663, 3656, 3670, 3687, 3725, 3755, 3788, 3929, 4170, 4224], 'control,': [27, 269], 'we': [28, 53, 270, 295, 1450, 3864, 4318, 4379, 4530], 'made': [29, 271, 1800, 1867], 'reporter': [30, 272, 1452, 3773, 3842], 'lines': [31, 273], 'with': [32, 101, 183, 274, 343, 425, 1456, 1658, 1695, 1815, 1883, 1953, 2211, 2424, 2436, 2476, 2528, 2734, 2824, 3033, 3054, 3152, 3216, 3317, 3424, 3491, 3607, 3620, 3639, 3758, 3813, 3844, 4084, 4102, 4157, 4172, 4216, 4227, 4325, 4334, 4385, 4465, 4487], 'a': [33, 71, 112, 127, 216, 275, 313, 354, 369, 458, 498, 642, 664, 672, 691, 697, 1058, 1098, 1129, 1242, 1255, 1330, 1503, 1509, 1576, 1743, 1756, 1790, 1930, 2014, 2093, 2114, 2127, 2274, 2431, 2437, 2800, 2814, 2839, 3041, 3078, 3095, 3110, 3173, 3212, 3510, 3551, 3571, 3621, 3675, 3733, 3745, 3814, 3818, 3827, 3845, 3881, 3947, 3993, 4030, 4158, 4284, 4326, 4339, 4524], 'green': [34, 108, 276, 350, 536, 581], 'fluorescent': [35, 109, 277, 351, 537, 582], 'protein': [36, 110, 278, 352], 'inserted': [38, 280, 1177, 1458, 1746, 1759, 2051], 'behind': [39, 281, 1460, 1748, 1760], 'promoter': [41, 283, 1365, 1462, 1750, 1762, 3645, 3726], 'different': [43, 285, 809, 820, 1181, 1204, 2828], 'ESs.': [44, 94, 286, 336, 701, 1465, 1514, 3653, 3862], 'We': [45, 68, 210, 287, 310, 452, 1466, 1490, 1571, 3184, 3673, 3836], 'attempted': [46, 288, 1467], 'disrupt': [48, 290, 1469], 'silencing': [50, 224, 292, 466, 1398, 1471, 1584, 3671], 'machinery,': [51, 293], 'and': [52, 62, 87, 142, 155, 157, 201, 225, 294, 304, 329, 384, 397, 399, 443, 467, 680, 763, 831, 881, 1193, 1295, 1367, 1484, 1508, 1585, 1607, 1616, 1666, 1755, 1767, 1798, 1821, 1846, 1865, 1890, 1913, 1980, 2001, 2050, 2058, 2097, 2105, 2136, 2147, 2214, 2220, 2253, 2265, 2289, 2357, 2372, 2389, 2442, 2468, 2595, 2643, 2696, 2718, 2772, 2787, 2793, 2805, 2812, 2830, 3008, 3225, 3245, 3278, 3282, 3343, 3354, 3380, 3386, 3396, 3461, 3562, 3613, 3821, 4060, 4186, 4390], 'used': [54, 296, 505, 550, 1611, 2676, 2843, 4420], 'fluorescence-activated': [55, 297, 532, 577], 'cell': [56, 298, 533, 578, 1478, 2836, 3311, 4281, 4549], 'sorter': [57, 299], 'analysis': [58, 300, 1481, 3313, 3806], 'for': [59, 301, 827, 1170, 1292, 1397, 1558, 1835, 1902, 2496, 2601, 2653, 2679, 2738, 2741, 2756, 2775, 3109, 3128, 3251, 3263, 3391, 3415, 3507, 3521, 3546, 3666, 3764, 3825, 3853, 4294, 4506], 'rapid': [61, 303, 1483, 3822], 'sensitive': [63, 305, 1485, 3820], 'detection': [64, 306, 1486], 'up-regulation.': [67, 309], 'find': [69, 311, 1491], 'that': [70, 75, 212, 312, 317, 454, 1187, 1199, 1246, 1389, 1492, 1533, 1837, 1904, 2834, 3102, 3186, 3938, 4008, 4300, 4317, 4521], 'range': [72, 128, 314, 370, 3846, 3883, 3994], 'treatments': [74, 118, 316, 360, 1493, 3996, 4007, 4290, 4520], 'either': [76, 184, 318, 426], 'block': [77, 319, 1504, 4340, 4371, 4525], 'nuclear': [78, 320, 4198, 4305, 4372, 4392, 4527], 'DNA': [79, 226, 240, 321, 468, 482, 661, 1495, 1499, 1586, 1590, 2429, 2689, 3135, 3500, 3624, 3999, 4035, 4063, 4108, 4134, 4140, 4155, 4195, 4199, 4306, 4342, 4373, 4377, 4393, 4528, 4551], 'synthesis,': [80, 322, 4343, 4529], 'like': [81, 323], 'aphidicolin,': [82, 324, 4386], 'or': [83, 134, 186, 325, 376, 428, 687, 1085, 1198, 1497, 2401, 2482, 2688, 2753, 2770, 3123, 3419, 3650, 4001, 4243, 4302], 'modify': [84, 326], 'DNA-like': [85, 327], 'cisplatin': [86, 328, 2993, 4032], '1-methyl-3-nitro-1-nitrosoguanidine': [88, 330], 'results': [89, 228, 331, 470, 1184, 3181, 4025], 'in': [90, 122, 205, 222, 229, 332, 364, 447, 464, 471, 682, 716, 723, 752, 808, 819, 1091, 1128, 1134, 1185, 1276, 1318, 1338, 1399, 1419, 1445, 1502, 1505, 1537, 1563, 1582, 1594, 1655, 1698, 1793, 1806, 1851, 1860, 1878, 1950, 2397, 2445, 2453, 2532, 2539, 2629, 2698, 2749, 2838, 3047, 3089, 3182, 3191, 3231, 3285, 3348, 3363, 3368, 3427, 3458, 3537, 3627, 3829, 3849, 3856, 3880, 3894, 3941, 3998, 4010, 4026, 4090, 4107, 4110, 4136, 4145, 4163, 4192, 4222, 4283, 4311, 4328, 4338, 4341, 4351, 4470, 4500, 4523, 4526, 4543, 4555], 'up-regulation': [91, 191, 333, 433, 1511, 1517, 1543, 1559, 3858, 3989, 4014, 4124, 4147, 4313, 4473, 4513], 'silent': [93, 113, 193, 335, 355, 435, 677, 1513, 1548, 3752, 3833, 3860, 3926, 3991, 4017, 4168, 4315, 4515], 'Aphidicolin': [95, 337, 4417], 'treatment': [96, 338, 3224, 3342, 4024, 4117], 'was': [97, 198, 202, 339, 440, 444, 1521, 1555, 1650, 1721, 1768, 1799, 1866, 1926, 1945, 2157, 2227, 2243, 2259, 2271, 2352, 2366, 2378, 2475, 2502, 2537, 2627, 2665, 2675, 2710, 2723, 2766, 2799, 3031, 3075, 3106, 3143, 3207, 3275, 3289, 3407, 3435, 3456, 3618, 4118, 4128, 4142, 4517, 4541], 'most': [99, 341], 'effective,': [100, 342], 'almost': [102, 344, 4488], '80%': [103, 345, 4481], 'cells': [106, 121, 180, 348, 363, 422, 2421, 2456, 2472, 2716, 2729, 3125, 3227, 3249, 3306, 3314, 3345, 3352, 3443, 4096, 4178, 4353, 4484, 4492], 'expressing': [107, 349, 3782, 4097, 4179, 4493], 'ES.': [114, 356, 2658, 2684, 3835], 'All': [115, 357], 'these': [117, 359, 1236, 2634, 3178, 3660, 4087, 4217], 'blocked': [119, 361], 'S': [123, 365, 1506, 4329], 'phase.': [124, 366], 'contrast,': [126, 368, 1317, 4184], 'toxic': [130, 372], 'chemicals': [131, 373, 3426, 3848, 4088], 'had': [132, 374, 1838, 1905, 3715, 3918, 4273], 'little': [133, 375], 'no': [135, 377, 1556, 3919, 3936, 4274], 'effect': [136, 378, 3921], 'on': [137, 379, 998, 1407, 1706, 1831, 1898, 2004, 2092, 2113, 2491, 2507, 2565, 2592, 2638, 2645, 3922], 'expression.': [138, 380], 'These': [139, 381, 1826, 1893], 'included': [140, 382, 4020], 'berenil': [141, 383, 2894, 4185], 'pentamidine,': [143, 385, 2781], 'which': [144, 386, 754, 2386, 3272, 3872, 4387], 'selectively': [145, 387, 4188, 4388], 'cleave': [146, 388], 'mitochondrial': [148, 390], 'kinetoplast': [149, 391, 4194], 'DNA,': [150, 392], 'metabolic': [152, 394, 4229], 'inhibitors': [153, 395], 'suramin': [154, 396, 2930, 4231], 'difluoromethylornithine,': [156, 398], 'mitotic': [159, 401], 'inhibitor': [160, 402, 3869, 4230, 4247], 'rhizoxin.': [161, 403], 'Up-regulation': [162, 404, 3629, 4320], 'also': [163, 177, 405, 419, 1522, 3276, 4105, 4119, 4143, 4161, 4272, 4535], 'affected': [164, 406], 'other': [165, 407, 4289], 'RNA': [166, 408, 1528, 3404, 3406, 3434, 3447, 3455], 'polymerase': [167, 409, 546, 591, 1529, 2122, 2213, 4394], 'I': [168, 195, 236, 410, 437, 478, 1257, 1530, 1601], '(pol': [169, 411], 'I)': [170, 412], 'transcription': [171, 196, 237, 413, 438, 479, 706, 1293, 1531, 1602, 2233, 3878], 'units,': [172, 414], 'as': [173, 415, 758, 760, 965, 1335, 1337, 1362, 1404, 1414, 1417, 1553, 2216, 2845, 3320, 4127, 4344], 'procyclin': [174, 416, 1519, 3576, 3600, 3615], 'genes': [175, 417, 679, 714, 833, 1089], 'were': [176, 181, 418, 423, 1612, 1620, 1703, 1828, 1895, 1982, 2002, 2293, 2387, 2422, 2457, 2494, 2563, 2576, 2636, 2694, 2732, 2789, 2821, 2832, 3046, 3092, 3126, 3228, 3254, 3298, 3315, 3346, 3361, 3402, 3489, 3658], 'up-regulated': [178, 420], 'after': [179, 239, 421, 481, 1568, 1589, 2578, 3341, 4519], 'treated': [182, 424, 2733, 3277, 3414, 4352], 'aphidicolin': [185, 427, 2847, 4468], 'DNA-modifying': [187, 429, 4021, 4335], 'agents.': [188, 430, 4022], 'Strikingly,': [189, 431], 'this': [190, 432, 1102, 1400, 1542, 3737, 3978, 4533], 'pol': [194, 235, 436, 477, 544, 589, 1256, 1600], 'units': [197, 238, 439, 480, 707, 1532, 3879], 'bloodstream': [199, 218, 441, 460, 1020, 1262, 1340, 1446, 1539, 1578, 1617, 2383, 2742, 2762, 3410, 3913, 3942, 4080, 4381, 4460], 'form-specific': [200, 219, 442, 461, 1579], 'not': [203, 445, 1027, 1054, 1150, 1334, 3931, 3981, 3987, 4220, 4355], 'observed': [204, 446, 4345, 4518, 4537], 'insect': [206, 448, 1319, 1564, 1972, 2719, 2757], 'form': [207, 449, 1021, 1263, 1320, 1341, 1447, 1565, 1618, 1647, 1941, 1973, 2384, 2707, 2720, 2743, 2758, 2763, 3411, 3914, 3943, 4081, 4112, 4382, 4461, 4557], 'T.': [208, 450, 776, 788, 869, 1007, 1022, 1264, 1321, 1448, 1453, 1566, 1604, 1613, 1624, 1632, 1648, 1717, 1739, 1786, 1812, 1852, 1855, 1870, 1919, 1937, 1942, 1974, 2183, 2195, 2322, 2334, 2375, 2525, 2624, 2685, 2708, 2721, 2744, 2759, 2764, 2956, 3140, 3149, 3200, 3269, 3412, 3636, 3689, 3712, 3728, 3741, 3775, 3780, 3809, 3839, 3901, 3915, 3944, 4082, 4279, 4332, 4383, 4462, 4539, 4558], 'brucei.': [209, 451, 2760], 'postulate': [211, 453, 1572], 'redistribution': [214, 456], 'limiting': [217, 459, 1289, 1577], 'factor': [220, 462, 1580, 4310], 'involved': [221, 463, 1090, 1581], 'both': [223, 465, 1583, 3610, 4085], 'repair': [227, 469], 'derepression': [231, 473, 1596, 3875, 3923], 'normally': [233, 475, 1535, 1547, 1598, 4016], 'silenced': [234, 476, 1416, 1464, 1561, 1599, 1847, 1914, 3308, 3815, 3877, 3939, 4476], 'damage.': [241, 483], 'trypanosomes': [485, 1186, 1239, 1610, 1827, 1836, 1894, 1903, 2562, 2635, 3812, 4424], 'including': [486], 'evade': [489], 'immune': [490], 'attack': [491], 'during': [492, 3058], 'chronic': [493], 'infections': [494], 'by': [495, 641, 660, 696, 969, 1801, 1868, 1873, 1929, 2085, 2099, 2118, 2273, 2295, 2597, 3209, 3280, 3300, 3494, 3732, 4346], 'periodically': [496], 'switching': [497, 1238, 2501, 2584], '1The': [503, 548], 'abbreviations': [504, 549], 'are:': [506, 551], 'VSG,': [507, 552], 'glycoprotein;': [510, 555], 'BAC,': [511, 556], 'bacterial': [512, 557, 1409], 'artificial': [513, 558, 1410], 'chromosome;': [514, 559], 'BrdUrd,': [515, 560], '5-bromo-2′-deoxyuridine;': [516, 561], 'DFMO,': [517, 562], 'difluoromethylornithine;': [518, 563], 'ES,': [519, 564, 2554, 3770], 'site;': [521, 566], 'ESAG,': [522, 567], 'site': [524, 529, 569, 574, 1252, 2090], 'associated': [525, 570], 'gene;': [526, 571], 'ESB,': [527, 572], 'body;': [530, 575], 'FACS,': [531, 576, 3281], 'sorter;': [534, 579], 'GFP,': [535, 580, 1849, 3274, 4126, 4486], 'protein;': [538, 583], 'eGFP,': [539, 584], 'enhanced': [540, 585], 'GFP;': [541, 586], 'MNNG,': [542, 587, 2779], '1-methyl-3-nitro-1-nitrosoguanidine;': [543, 588], 'I,': [545, 590], 'I.': [547, 592, 1154, 1207, 1225, 1774, 2042, 2612, 2873, 2972, 3695], 'coat': [593, 1691], '(1Barry': [594], 'J.D.': [595, 1115], 'McCulloch': [596, 1106], 'R.': [597, 843, 854, 858, 908, 952, 1045, 1107, 1349, 1731, 1962, 1992, 2040, 2068, 2945, 4252, 4358, 4407, 4411], 'Adv.': [598], 'Parasitol.': [599, 610, 631, 737, 797, 863, 1014, 1080, 1230, 1431, 1677, 1781, 2204, 2343, 2619, 2878, 2889, 2962, 3003, 3166, 3702, 3973, 4238, 4453], '2001;': [600, 611, 632, 738, 1271], '49:': [601], '1-70Google': [602], 'Scholar,': [603, 614, 622, 850, 867, 918, 1037, 1073, 1221, 2882, 3966, 4258, 4405, 4446], '2Borst': [604], 'P.': [605, 792, 845, 860, 911, 924, 936, 950, 1009, 1047, 1137, 1162, 1215, 1227, 1300, 1304, 1351, 1640, 1733, 1778, 1994, 2070, 2199, 2283, 2338, 2616, 2875, 3068, 3699, 4071, 4262], 'Ulbert': [606], 'S.': [607, 728, 778, 1223, 2030, 2185, 2324, 2519, 2871, 2906, 2924, 3899, 4209, 4399], 'Mol.': [608, 735, 795, 861, 875, 1012, 1078, 1228, 1310, 1429, 1779, 2202, 2341, 2617, 2876, 2887, 3164, 3700, 3971, 4236, 4451], 'Biochem.': [609, 736, 796, 862, 1013, 1079, 1229, 1430, 1780, 2203, 2342, 2618, 2877, 2888, 3165, 3701, 3972, 4237, 4452], '114:': [612, 739], '17-27Google': [613], '3Donelson': [615], 'J.E.': [616], 'Acta': [617, 1965, 2946, 2987, 4253], 'Trop.': [618, 1966, 2947, 2988, 4254], '2003;': [619, 877, 956, 1015, 1432, 3167, 3336], '85:': [620], '391-404Google': [621], '4Vanhamme': [623], 'L.': [624, 626, 732, 782, 893, 920, 928, 1298, 2189, 2328], 'Lecordier': [625], 'Pays': [627, 902, 912, 933, 953, 1301, 1308], 'E.': [628, 726, 913, 954, 1067, 1309, 1378, 2943, 2958, 2978, 3960, 4250], 'Int.': [629, 4053], 'J.': [630, 874, 901, 932, 1069, 1116, 1164, 1217, 1353, 1380, 1676, 1996, 2043, 2072, 2860, 3022, 3326, 3333, 3467, 3594, 3962, 4041, 4054, 4265, 4361, 4400, 4440], '31:': [633], '523-531Google': [634], 'Scholar).': [635, 741, 801, 959, 983, 1018, 1122, 1142, 1168, 1234, 1274, 1315, 1357, 1384, 1435, 1645, 1681, 1738, 1785, 1970, 2076, 2347, 2417, 2524, 2623, 3028, 3073, 3170, 3339, 3598, 3906, 4077, 4214, 4367, 4416, 4457], 'predominant': [637], 'is': [639, 658, 747, 750, 1026, 1359, 1364, 1387, 1395, 1525, 1550, 2080, 3509, 3525, 3550, 3570, 3578, 3789, 3935, 3980, 4297, 4307, 4553], 'encoded': [640], 'transcribed': [644, 1127, 1526], '1': [646, 2555, 2559, 3369], 'telomeric': [650, 720, 1391], '(ES).': [654], 'Switching': [655, 802], 'coats': [657], 'mediated': [659, 695], 'rearrangements': [662], 'moving': [663], 'new': [665], 'into': [667, 3138, 3177, 3198, 3682, 4034], 'repertoire': [673], 'hundreds': [675], 'pseudogenes': [681], 'chromosome': [683], 'internal': [684], 'tandem': [685], 'arrays': [686, 971, 992], 'at': [688, 1652, 1947, 2392, 2462, 2712, 2725, 3094, 3247, 3356, 3388, 4121, 4425, 4495], 'telomeres.': [689], 'Alternatively,': [690, 2761], 'switch': [692, 699, 1201, 2550], 'can': [693, 811, 3602], 'be': [694, 1327, 3603, 3799, 4536], 'transcriptional': [698, 995, 1258], 'between': [700, 803, 1202, 1241, 2052, 2464], 'large': [703, 3179], 'polycistronic': [704, 961], 'contain': [708], 'an': [709, 1250, 1277, 2630, 3217, 3397, 3445, 3526, 3785], 'assortment': [710], 'site-associated': [713], '(ESAGs)': [715], 'addition': [717, 1660, 1955], '(reviewed': [722, 1133, 3893], 'Ref.': [724, 1135, 3062, 3465, 3895], '5Pays': [725], 'Lips': [727], 'Nolan': [729, 925], 'D.': [730, 734, 976, 1030, 1424, 2960, 3159, 3586, 4044, 4048, 4409], 'Vanhamme': [731, 892], 'Perez-Morga': [733], '1-16Google': [740], 'Although': [742, 3907, 3983], 'basic': [744], 'structure': [746, 3951], 'conserved,': [748], 'there': [749, 1554, 3934], 'variation': [751], 'exactly': [753], 'ESAGs': [755, 806], 'are': [756, 963, 1126, 1413, 1534, 2112, 2844], 'present,': [757], 'well': [759], 'their': [761], 'number': [762, 2170, 2309, 3132, 3542], '(6Berriman': [765, 2172, 2311], 'M.': [766, 786, 790, 895, 945, 1005, 1063, 1075, 1160, 1213, 1267, 1374, 1964, 2173, 2193, 2197, 2312, 2332, 2336, 3330, 3897, 3956, 3968, 4065, 4067], 'Hall': [767, 2174, 2313], 'N.': [768, 906, 943, 1426, 2175, 2314, 3161], 'Sheader': [769, 2176, 2315, 3561], 'K.': [770, 1003, 1269, 1675, 2177, 2316, 2859, 3021, 3588, 4360, 4439], 'Bringaud': [771, 2178, 2317], 'F.': [772, 922, 2179, 2318, 3328], 'Tiwari': [773, 2180, 2319], 'B.': [774, 2181, 2320], 'Isobe': [775, 1006, 2135, 2182, 2321], 'Bowman': [777, 2184, 2323, 4234], 'Corton': [779, 2186, 2325], 'C.': [780, 1105, 2187, 2326], 'Clark': [781, 2188, 2327, 3325], 'Cross': [783, 977, 1031, 1064, 1076, 1159, 1212, 1375, 2190, 2329, 2512, 3957, 3969], 'G.A.': [784, 978, 1032, 1065, 1077, 1376, 2191, 2330, 2513, 3958, 3970], 'Hoek': [785, 2192, 2331], 'Zanders': [787, 2194, 2333], 'Berberof': [789, 1004, 2196, 2335], 'Borst': [791, 844, 859, 1008, 1046, 1161, 1214, 1226, 1350, 1639, 1732, 1777, 1993, 2069, 2198, 2337, 2615, 2874, 3067, 3698], 'Rudenko': [793, 872, 1010, 1155, 1208, 1427, 2200, 2339, 3162], 'G.': [794, 873, 1011, 1039, 1156, 1209, 1343, 1428, 1725, 1772, 1986, 2062, 2137, 2201, 2340, 2610, 2980, 3163, 3563, 3584, 3693, 4069, 4397], '2002;': [798, 864, 1119, 1139, 1231, 2205, 2344, 2879, 2963, 2989], '122:': [799, 2206, 2345], '131-140Google': [800, 2207, 2346], 'polymorphic': [805, 829], 'present': [807, 2091], 'ESs': [810, 962, 1125, 1148, 1205, 1324, 1394, 1562, 3940, 3954, 4019, 4316, 4323, 4516], 'allow': [812], 'adapt': [816], 'life': [818, 1401, 1551], 'hosts.': [821], 'This': [822, 4116], 'has': [823, 1247, 1742, 1789, 1858, 2013, 4418], 'been': [824, 1248, 4419], 'best': [825], 'investigated': [826, 4531], 'ESAG6': [830], '-7': [832], 'encoding': [834, 1932], 'transferrin': [835], 'receptor': [836], 'subunits': [837], '(7Bitter': [838], 'W.': [839, 856], 'Gerrits': [840], 'H.': [841, 852, 939, 1307, 1673, 4050], 'Kieft': [842, 857, 1044, 1348, 1730, 1991, 2067], 'Nature.': [846, 955, 1270], '1998;': [847, 915, 1081, 1782, 2620, 3703, 3974], '391:': [848], '499-502Google': [849], '8Gerrits': [851], 'MuBmann': [853], 'Bitter': [855], '119:': [865], '237-247Google': [866], '9Isobe': [868], 'Holmes': [870], 'E.C.': [871], 'Evol.': [876], '56:': [878], '377-386Google': [879], 'Scholar)': [880, 2000, 2049, 2208, 3706, 4242, 4271], 'serum': [883, 888, 1665, 1960], 'resistance-associated': [884], 'conferring': [886], 'human': [887], 'resistance': [889, 1824, 1924, 1934, 2016, 2269, 2276, 3677], '(10Xong': [890], 'H.V.': [891], 'Chamekh': [894], 'Chimfwembe': [896], 'C.E.': [897], 'Van': [898, 904, 929, 937, 1305, 3589], 'Den': [899, 930], 'Abbeele': [900, 931], 'A.': [903, 934, 941, 1043, 1113, 1158, 1211, 1302, 1629, 1729, 1776, 2032, 2038, 2520, 2614, 2851, 2907, 2925, 2982, 3013, 3697, 4210, 4431], 'Meirvenne': [905], 'Hamers': [907], 'De': [909, 948], 'Baetselier': [910, 949], 'Cell.': [914, 979, 1033, 1048, 1138, 1641, 1734, 3069], '95:': [916, 1783, 2621, 3704, 4365], '839-846Google': [917], '11Vanhamme': [919], 'Paturiaux-Hanocq': [921], 'Poelvoorde': [923, 1299], 'D.P.': [926], 'Lins': [927], 'Tebabi': [935, 1303], 'Xong': [938, 1306], 'Jacquet': [940], 'Moguilevsky': [942], 'Dieu': [944], 'Kane': [946], 'J.P.': [947], 'Brasseur': [951], '422:': [957], '83-87Google': [958], 'regulated': [964], 'domains': [966], 'flanked': [967, 2083], 'upstream': [968, 987, 2084], 'extensive': [970], '50-bp': [973, 990], 'repeats': [974], '(12Horn': [975, 1029], '1995;': [980, 1034, 1049, 1735, 3903], '83:': [981, 1035, 1050, 1736], '555-561Google': [982, 1036], 'Exogenous': [984], 'promoters': [985, 1183, 1406, 3657], 'integrated': [986], 'repeat': [991], 'escape': [993], 'control': [996, 1025], 'operating': [997], 'downstream': [1000, 1179, 2098, 2109, 2230, 3642, 3720, 3749], '(13Sheader': [1002], '128:': [1016, 1433, 3168], '147-156Google': [1017], 'brucei,': [1023, 1449, 3916], 'sequence-specific': [1028, 1366], '14Rudenko': [1038], 'Blundell': [1040, 1344, 1726, 1987, 2063], 'P.A.': [1041, 1345, 1634, 1727, 1988, 2064], 'Dirks-Mulder': [1042, 1157, 1210, 1728, 1775, 2613, 3696], '547-553Google': [1051, 1737], 'Scholar),': [1052, 1084, 2866, 2893, 2911, 2929, 2951, 2966, 2992, 3007, 3977, 4059], 'does': [1053, 1149], 'appear': [1055, 1151, 1325], 'involve': [1057, 1370], 'repressed': [1059, 1371, 3891, 3949], 'chromatin': [1060, 1372, 3892, 3950], 'state': [1061], '(15Navarro': [1062, 1373, 3955], 'Wirtz': [1066, 1377, 3959], 'EMBO': [1068, 1163, 1216, 1352, 1379, 1995, 2071, 3593, 3961], '1999;': [1070, 1165, 1218, 1381, 2863, 3025, 3963, 4443], '18:': [1071, 1166, 1219, 1382, 3964], '2265-2272Google': [1072, 1383, 3965], '16Navarro': [1074, 3967], '94:': [1082, 3975], '53-66Google': [1083, 3976], 'require': [1086], 'homologues': [1087], 'yeast': [1092], 'telomere': [1093], 'position': [1094], 'effect,': [1095, 4276], 'despite': [1096, 4277], 'having': [1097], 'superficial': [1099], 'resemblance': [1100], 'phenomenon': [1103], '(17Conway': [1104], 'Ginger': [1108], 'M.L.': [1109], 'Robinson': [1110, 2852, 3014, 4432], 'N.P.': [1111], 'Browitt': [1112], 'Barry': [1114], 'Biol.': [1117, 2045, 3334, 4266], 'Chem.': [1118, 3335, 4267], '277:': [1120], '21269-21277Google': [1121], 'multiple': [1124], 'mutually': [1130], 'exclusive': [1131], 'fashion': [1132, 4286], '18Borst': [1136], '109:': [1140], '5-8Google': [1141], 'Stable': [1143], 'maximal': [1144, 4496], 'activation': [1145, 2654, 2664], 'two': [1147, 1203], 'possible': [1152], '(19Chaves': [1153, 1206], '4846-4855Google': [1167, 1220], 'Selection': [1169, 2474], 'double': [1171], 'expressors': [1173], 'using': [1174, 1473, 2120, 2141, 2209, 2249, 2354, 2368, 2380, 2430, 2504, 3040, 3077, 3145, 3211, 3256, 3444, 3497], 'selectable': [1175], 'markers': [1176, 1697], 'immediately': [1178, 1459, 1747, 3641], 'have': [1188, 3946], 'maximally': [1191], 'another': [1194], 'partially': [1196], 'up-regulated,': [1197], 'rapidly': [1200, 1237], '20Ulbert': [1222], 'Chaves': [1224, 1773, 2611, 2872, 3694], '120:': [1232, 2880], '225-235Google': [1233, 2881], 'Possibly': [1235], 'alternate': [1240], 'privileged': [1243], 'subnuclear': [1244], 'location': [1245, 1392], 'called': [1249], 'body': [1253, 1259], '(ESB),': [1254], 'specific': [1260], '(21Navarro': [1266], 'Gull': [1268, 2858, 3020, 4359, 4438], '414:': [1272], '759-763Google': [1273], 'Location': [1275], 'ESB': [1278], 'transcription/RNA': [1279], 'processing': [1280], 'factory': [1281], 'may': [1282], 'give': [1283], 'access': [1287], 'factors': [1290], 'necessary': [1291], 'elongation': [1294], 'polyadenylation': [1296, 2059, 2106], '(22Vanhamme': [1297], 'Microbiol.': [1311], '2000;': [1312, 4056, 4074], '36:': [1313, 1643, 1968, 4403], '328-340Google': [1314], 'all': [1323, 1621, 2790], 'down-regulated': [1328, 1536], 'great': [1331], 'extent,': [1332], 'although': [1333], 'tightly': [1336], '(23Rudenko': [1342, 1985, 2061], 'Taylor': [1346, 1989, 2065], 'M.C.': [1347, 1990, 2066, 4448], '1994;': [1354, 1997, 2073], '13:': [1355, 1998, 2074], '5470-5482Google': [1356, 1999, 2075], 'Silencing': [1358], 'mechanistically': [1360], 'different,': [1361], 'it': [1363, 1386, 3797, 3917], 'appears': [1368], 'However,': [1385], 'unlikely': [1388], 'critical': [1396], 'cycle': [1402, 3312], 'stage,': [1403], 'circular': [1408], 'chromosomes': [1411], '(BACs)': [1412], 'effectively': [1415], 'those': [1418, 3854], 'genome': [1421, 3142], '(24te': [1422, 3157], 'Vruchte': [1423, 3158], 'Aitcheson': [1425, 3160], '123-133Google': [1434, 3169], 'investigate': [1439], 'machinery': [1441, 1472], 'mediating': [1442], 'down-regulation': [1444], 'constructed': [1451, 3635], 'strains': [1455, 3638, 3661], 'GFP': [1457, 1791, 1820, 1859, 1889, 2078, 3206, 3631, 3640, 3681, 3783, 3816, 4098, 4149, 4180, 4477, 4494], 'various': [1474, 3425], 'chemical': [1475, 2737, 3267], 'treatments.': [1476, 1570], 'Fluorescence-activated': [1477], 'sorting': [1479], '(FACS)': [1480], 'allowed': [1482, 3662, 3760], 'derepression.': [1489, 4225], 'inhibiting': [1494, 4278], 'synthesis': [1496, 4374, 4552], 'causing': [1498], 'damage': [1500, 1591, 4002, 4135, 4303], 'result': [1501, 1593, 3979, 4221], 'phase': [1507, 2382, 2692, 4428, 4546], 'concurrent': [1510], 'addition,': [1516, 3296], 'transcript': [1520, 3608], 'observed.': [1523, 4319], 'Procyclin': [1524], 'form.': [1540], 'Surprisingly,': [1541], 'transcripts': [1545], 'cycle-specific,': [1552], 'evidence': [1557, 3937], 'comparable': [1569, 2840, 4285], 'presence': [1574, 2541], 'repair.': [1587], 'Redistribution': [1588], 'could': [1592, 4534], 'units.': [1603], 'Transformants': [1606], 'Culturing': [1608], 'Conditions—All': [1609], '427,': [1615], 'variants': [1619], 'derived': [1622], '427': [1626, 1944], 'VSG221a': [1627], '(25Bernards': [1628], 'de': [1630, 4037, 4042], 'Lange': [1631], 'Michels': [1633], 'Liu': [1635], 'A.Y.': [1636], 'Huisman': [1637], 'M.J.': [1638, 2406], '1984;': [1642], '163-170Google': [1644], 'Bloodstream': [1646, 2706], 'maintained': [1651, 1705, 1946, 2003, 2538, 2637], '37': [1653, 3389], '°C': [1654, 1949, 3358, 3390], 'HMI-9': [1656, 2454, 3090], 'medium': [1657, 1952, 2700, 3091], '10%': [1662, 1667, 1957], 'fetal': [1663, 1958], 'calf': [1664, 1959], 'Serum': [1668], 'Plus': [1669], '(JRH': [1670], 'Biosciences)': [1671], '(26Hirumi': [1672], 'Hirumi': [1674], '1989;': [1678, 3595], '75:': [1679], '985-989Google': [1680], 'ensure': [1685], 'population': [1686], 'homogeneity': [1687], 'expressed,': [1692], 'transformants': [1694, 1976, 2493], 'drug': [1696, 1709, 2505, 2703, 3431], 'continuously': [1704], 'appropriate': [1708, 2736], 'selection': [1710, 2492, 2506, 2704, 3432, 3757], 'pressure': [1711], 'prevent': [1713], 'switching.': [1715], 'RP2X-1': [1719], 'transformant': [1720, 3711], 'described': [1722, 1769, 1983, 3321], 'previously': [1723, 1770, 1984, 2605, 3322, 4421], '(14Rudenko': [1724], 'HNI': [1741, 3743], 'hygromycin': [1744, 1804, 1899, 1908, 1923, 2649, 3717], '221': [1753, 1796, 1809, 1911, 2101, 2132, 2153, 2165, 2239, 2535, 2607, 2657, 2662, 3523, 3531, 3649, 3685, 3723, 3927], 'neomycin': [1757, 1841, 1876, 3746], 'VO2': [1765, 1844, 1863, 1881, 1916, 2305, 2553, 2683, 3548, 3557, 3651, 3753, 3768], '(27Rudenko': [1771, 2609, 3692], '97-109Google': [1784, 2622, 3705], '221GP1(221+)': [1788, 2527, 3714], 'replacing': [1802, 1874], 'HNI(221+)': [1814, 3691, 3730], '221GP1': [1817, 2011, 2263], 'construct': [1818, 1886, 2012, 2020, 2226, 2258, 2279], 'containing': [1819, 1887, 2056, 2163, 2301, 2568, 3148, 3307, 3374], 'puromycin': [1823, 1933, 2015, 2268, 2480, 2530, 2546, 3676, 3734], 'gene.': [1825, 3735], 'subsequently': [1829, 1896, 1927], 'selected': [1830, 1897, 2644], 'G418': [1832, 2572, 3759], 'select': [1834, 1901, 2652], 'activated': [1839, 1906], 'marked': [1843, 1910], 'resulting': [1850, 3710, 3855, 3997], '221GP1(VO2+).': [1854], 'VO2GP1(VO2+)': [1857, 2626], 'modifying': [1869], 'HNI(VO2+)': [1872], 'VO2GP1': [1885, 2257], 'blasticidin': [1891, 2275, 2486, 2641], 'genes.': [1892], 'producing': [1918, 3771, 4122], 'VO2GP1(221+).': [1921], 'replaced': [1928, 2272, 3731], 'create': [1936], 'VO2GP2(221+).': [1939], 'Insect': [1940], '27': [1948], 'SDM-79': [1951], '(28Brun': [1961], 'Schonenberger': [1963], '1979;': [1967], '289-292Google': [1969], '(RPX1-1,': [1977], 'ESX1-1,': [1978], 'ESX1-2,': [1979], 'rDES1-1)': [1981], '25': [2005, 3048], 'μg': [2006, 2426, 2478, 2484, 2544, 2570, 2647, 2936, 3376, 3382, 3452], 'ml–1': [2007, 2396, 2479, 2485, 2547, 2642, 2650, 3250, 3377, 3383], 'hygromycin.': [2008], 'Transfection': [2009], 'Constructs—The': [2010], 'excised': [2018], 'pBS-Pur': [2021], '(gift': [2022, 2281], 'Isabel': [2024], 'Roditi,': [2025], 'University': [2026], 'Berne)': [2028], '(29Ruepp': [2029], 'Furger': [2031], 'Kurath': [2033], 'U.': [2034, 2518, 2905, 2923, 4208], 'Renggli': [2035], 'C.K.': [2036], 'Hemphill': [2037], 'Brun': [2039], 'Roditi': [2041], 'Cell': [2044, 2861, 3023, 4362, 4441], '1997;': [2046], '137:': [2047], '1369-1379Google': [2048], 'tubulin': [2053, 2087, 2094, 3568], 'intergenic': [2054, 2095], 'regions': [2055], 'splice': [2057, 2089], 'eGFP': [2081, 3508, 3516], '(Clontech)': [2082], '3′': [2088, 2238, 2363], 'region,': [2096], 'untranslated': [2103], 'region': [2104], 'signal.': [2107], 'flanking': [2110], 'sequences': [2111], '612-bp': [2115], 'fragment': [2116, 2156, 2242, 2351, 2365, 3513, 3528, 3554], 'amplified': [2117, 2158, 2294, 2353, 2367], 'PCR': [2119, 2210, 2296, 2598, 2674], 'Pwo': [2121, 2212], '(Roche': [2123], 'Applied': [2124], 'Science)': [2125], 'genomic': [2128], 'clone': [2129], '2T.': [2134], 'Rudenko,': [2138, 3564], 'unpublished': [2139, 3565], 'data.': [2140, 3566], 'following': [2143], 'primers:': [2144], '221VSG3445s,': [2145], '5′-TTTCCCCCCTCAAATTTCCCC-3′,': [2146], '221VSG4057as,': [2148], '5′-CGAAAAATTAAGATTCAAAACCACGG-3′.': [2149], '1.3-kb': [2151], '5′': [2152, 2349], 'target': [2155, 2241, 2291, 2350, 2364], 'H25N7': [2161, 2247], 'BAC': [2162, 2248, 2300], '(GenBank™': [2168, 2307, 3540], 'account': [2169, 2308, 3541], 'AL671259)': [2171], 'primers': [2215, 2250, 2359, 2369], 'follows:': [2217, 2846], 'HNES481s,': [2218], '5′-TTAAGCTTTCTAACACTTCCTTTTTG-3′,': [2219], 'VO228551as,': [2221], '5′-AACCTCAATGGACGAAGGAG-3′.': [2222], 'Integration': [2223], '216': [2228], 'bp': [2229], 'start': [2234], 'site.': [2235], '714-bp': [2237], 'isolated': [2244, 3408, 3436], '221–73592s': [2251], '5′-ACGAAGAGCAGGGGTGCAAC-3′': [2252], 'HNES4244as': [2254], '5′-GCTTCATCTGC-TGGTCGTCTTC-3′.': [2255], 'analogous': [2260, 2631], 'construct,': [2264], 'only': [2266, 2633], 'tubBSRtub': [2280], 'Borst,': [2284], 'Netherlands': [2285], 'Cancer': [2286, 2809], 'Institute,': [2287, 2810], 'Amsterdam),': [2288], 'fragments': [2292], 'N19B2': [2299], 'part': [2302], 'AL671256)': [2310], 'HNES481s': [2356], 'VO228551as': [2358], 'listed': [2360], 'above.': [2361], 'VO2–118336s': [2370], '5′-CTCTAGTGAGCGTATTTTAGAGG-3′': [2371], 'HNES': [2373], '4244as.': [2374], 'Transformation—Transfection': [2377], 'performed': [2379, 2503, 2823, 3032, 3076, 3619], 'mid-log': [2381], 'trypanosomes,': [2385], 'washed': [2388, 3229, 3362], 'then': [2390, 2773], 'resuspended': [2391, 2697, 2711, 2724, 3246, 3367], '5': [2393, 2569, 2646, 2713, 2726, 3440, 3451], '×': [2394, 2419, 2466, 2470, 2556, 2560, 2589, 2667, 2714, 2727, 3441], '107': [2395, 2420, 2561, 3442], 'cytomix': [2398], 'without': [2399, 4375], 'glutathione': [2400], 'ATP': [2402], '(30van': [2403], 'den': [2404], 'Hoff': [2405], 'Moorman': [2407], 'A.F.': [2408], 'Lamers': [2409], 'W.H.': [2410], 'Nucleic': [2411], 'Acids': [2412], 'Res.': [2413, 4073], '1992;': [2414, 2521], '20:': [2415], '2902Google': [2416], '2.5': [2418], 'electroporated': [2423], '10': [2425, 3375, 3381], 'linearized': [2428], 'Bio-Rad': [2432, 3622], 'Gene': [2433], 'Pulser': [2434], 'II': [2435], 'single': [2438, 3174], 'pulse': [2439], '1.5-kV': [2441], '25-microfarad': [2443], 'capacitance': [2444], '0.2-cm': [2446], 'cuvettes': [2447], '(Bio-Rad).': [2448], 'After': [2449, 2488, 3116, 3223], '∼6': [2450], 'h': [2451, 2740, 2755, 3421], 'recovery': [2452], 'medium,': [2455], 'distributed': [2458], 'over': [2459], '24-wells': [2460], 'plates': [2461, 2509, 2567], 'densities': [2463], '7': [2465], '104': [2467], '3': [2469, 2666, 3236], '105': [2471, 2557, 2715], 'ml–1.': [2473, 2574, 2730], '0.2': [2477, 2543], '(Sigma)': [2481], '2': [2483, 2639], '(Invitrogen).': [2487], '5–7': [2489], 'days': [2490, 2580], 'expanded': [2495], 'further': [2497], 'analysis.': [2498, 3252], 'Switching—ES': [2500], 'agarose': [2508, 2566, 3146], '(31Carruthers': [2510], 'V.B.': [2511], 'Proc.': [2514, 2901, 2919, 4204], 'Natl.': [2515, 2902, 2920, 4205], 'Acad.': [2516, 2903, 2921, 4206], 'Sci.': [2517, 2862, 2904, 2922, 3024, 4207, 4363, 4442], '89:': [2522, 4057], '8818-8821Google': [2523], '(Sigma).': [2548], 'To': [2549, 3261], 'spread': [2564], '(Invitrogen)': [2573], 'Colonies': [2575], 'counted': [2577], '9–10': [2579], 'determine': [2582], 'frequency': [2585, 2660], '(average': [2586, 2669], '4.4': [2588, 3107], '10–6': [2590, 2668], 'determined': [2591], 'three': [2593], 'plates)': [2594], 'analyzed': [2596, 3208, 3255, 3279], 'check': [2600], 'retention': [2602, 2680], 'switched': [2628], 'fashion;': [2632], 'μgof': [2640], 'four': [2671], 'plates).': [2672], 'Again': [2673], 'monitor': [2678], 'Chemical': [2687], 'Damage': [2690, 3625], 'Treatments—Mid-log': [2691], 'cultures': [2693], 'pelleted': [2695], 'fresh': [2699], 'remove': [2702], 'pressure.': [2705, 3433], 'ml–1,': [2717], '106': [2728, 3248], 'Cultures': [2731], '24': [2739, 2776, 3129, 3416], 'unless': [2746], 'stated': [2747], 'otherwise': [2748], 'figure': [2751], 'legends': [2752], '48': [2754, 3420], 'exposed': [2767], 'UV': [2769, 3029, 3036, 3042, 3122, 4103], 'γ-radiation': [2771], 'recovered': [2774, 3127], 'h.': [2777, 3130], 'Aphidicolin,': [2778], 'berenil,': [2780], 'suramin,': [2782], 'trichostatin': [2783, 2933, 3870, 3908, 3984], 'A,': [2784, 3385, 3871], 'difluoromethylornithine': [2785], '(DFMO),': [2786], 'pCPT-cAMP': [2788, 2952], 'Sigma,': [2792], 'ethidium': [2794, 2967, 4132], 'bromide': [2795, 2968], 'BDH.': [2797], 'Cisplatin': [2798, 4023], 'gift': [2801, 2815], 'Adrian': [2803], 'Begg': [2804, 4051], 'Ben': [2806], 'Floot': [2807], '(Netherlands': [2808], 'Amsterdam)': [2811], 'rhizoxin': [2813, 3009], 'Keith': [2817], 'Gull.': [2818], 'Growth': [2819], 'curves': [2820], 'initially': [2822], 'each': [2825], 'substances,': [2829], 'concentrations': [2831], 'chosen': [2833], 'flattened': [2835], 'growth': [2837, 3911, 4282], 'fashion.': [2841], 'Concentrations': [2842], '(30': [2848], 'μm)': [2849, 2896, 2914, 2941, 2970, 2995], '(32Ploubidou': [2850, 3012, 4430], 'D.R.': [2853, 3015, 4433], 'Docherty': [2854, 3016, 4434], 'R.C.': [2855, 3017, 4435], 'Ogbadoyi': [2856, 3018, 4436], 'E.O.': [2857, 3019, 4437], '112:': [2864, 3026, 4444], '4641-4650Google': [2865, 3027, 4445], 'MNNG': [2867, 4061], '(2': [2868, 2935], 'μgml–1)': [2869], '(20Ulbert': [2870], '33King': [2883], 'D.L.': [2884], 'Turco': [2885], 'S.J.': [2886], '1988;': [2890], '28:': [2891], '285-293Google': [2892], '(1': [2895, 2913, 2953], '(34Shapiro': [2897, 2915, 4200], 'T.A.': [2898, 2916, 4201], 'Englund': [2899, 2917, 4202], 'P.T.': [2900, 2918, 4203], '1990;': [2908, 2926, 4211, 4364], '87:': [2909, 2927, 4212], '950-954Google': [2910, 2928, 4213], 'pentamidine': [2912, 4187], '(400': [2931], 'nm),': [2932], 'A': [2934, 3472, 3909, 3985], 'ml–1),': [2937], 'DFMO': [2938, 4248], '(difluoromethylornithine)': [2939], '(200': [2940], '(35Zweygarth': [2942, 4249], 'Kaminsky': [2944, 4251], '1991;': [2948, 4255, 4413], '48:': [2949, 4256], '223-232Google': [2950, 4257], 'mm)': [2954], '(36Breidbach': [2955], 'Ngazoa': [2957], 'Steverding': [2959], 'Exp.': [2961, 3002], '101:': [2964], '223-230Google': [2965], '(8': [2969], '(37Boibessot': [2971], 'Turner': [2973], 'C.M.': [2974], 'Watson': [2975], 'D.G.': [2976], 'Goldie': [2977], 'Connel': [2979], 'McIntosh': [2981], 'Grant': [2983], 'M.H.': [2984], 'Skellern': [2985], 'G.G.': [2986], '84:': [2990], '219-228Google': [2991], '(4': [2994], '(38Balber': [2996], 'A.E.': [2997], 'Gonias': [2998], 'S.L.': [2999], 'Pizzo': [3000], 'S.V.': [3001], '1985;': [3004], '59:': [3005], '74-80Google': [3006], '(10': [3010], 'nm)': [3011, 3039], 'irradiation': [3030, 3189], '3840': [3034], 'J/m2': [3035], 'light': [3037, 4104], '(254': [3038], 'cross-linker': [3043], '(Stratagene).': [3044], 'Cells': [3045, 3360], 'ml': [3049, 3370], 'tissue': [3051], 'culture': [3052], 'dishes': [3053], 'lid': [3056], 'removed': [3057], 'exposure': [3059, 3120], '(adapted': [3060], '39Johnson': [3063], 'P.J.': [3064, 4039], 'Kooter': [3065], 'J.M.': [3066], '1987;': [3070, 4268], '51:': [3071], '273-281Google': [3072], 'γ-Irradiation': [3074], '137Cs': [3079], 'source': [3080, 3100, 4160], '(Gravitron': [3081], 'RX30/55M,': [3082], 'Graviner': [3083], 'Manufacturing,': [3084], 'Gosport,': [3085], 'Hampshire,': [3086], 'UK).': [3087], 'Trypanosomes': [3088], 'placed': [3093], 'proximity': [3096], 'cesium': [3099, 4159], 'so': [3101], 'dose': [3104, 3112], 'rate': [3105], 'gray/min': [3108], 'total': [3111, 3454], '160': [3114, 3187], 'gray.': [3115], 'removal': [3117], 'γ-radiation,': [3124], 'double-strand': [3134, 3175, 3196, 4154, 4190], 'breaks': [3136, 3197, 4156, 4191], 'introduced': [3137, 3674], 'estimated': [3144, 3185], 'blocks': [3147], 'transfected': [3151], 'BACs': [3153], '∼150': [3155], 'kb': [3156], 'Introduction': [3171], 'break': [3176], 'circles': [3180], 'linearization.': [3183], 'gray': [3188], 'resulted': [3190, 4009, 4089, 4106, 4162, 4337, 4469, 4522], 'introduction': [3193, 4028, 4152], '∼370': [3195], 'genome.': [3202], 'FACS': [3203, 3210, 3805], 'Analysis—Derepression': [3204], 'BD': [3213], 'Biosciences': [3214], 'FACSCalibur': [3215], 'excitation': [3218], 'wavelength': [3219], '488': [3221], 'nm.': [3222], 'recovery,': [3226, 3344], 'once': [3230], 'PSG': [3232], '(60': [3233], 'mm': [3234, 3237, 3240, 3243], 'Na2HPO4,': [3235], 'NaH2PO4,': [3238], '44': [3239], 'NaCl,': [3241], '56': [3242], 'glucose)': [3244], 'Data': [3253], 'CellQuest': [3257], 'software': [3258], 'version': [3259], '3.3.': [3260], 'correct': [3262], 'fluorescence': [3264, 3284, 3303], 'used,': [3268], 'HNI,': [3271], 'lacks': [3273], 'any': [3283], 'FL-1': [3287], 'channel': [3288], 'subtracted': [3290], 'final': [3293], 'values.': [3294], 'values': [3297], 'corrected': [3299], 'subtracting': [3301], 'background': [3302], 'untreated': [3305], 'GFP.': [3309], 'For': [3310], 'stained': [3316], 'propidium': [3318, 3378], 'iodide': [3319, 3379], '(40Hammarton': [3323], 'T.C.': [3324], 'Douglas': [3327], 'Boshart': [3329], 'Mottram': [3331], 'J.C.': [3332], '278:': [3337], '22877-22886Google': [3338], 'Briefly,': [3340], 'fixed': [3347], '70%': [3349], 'methanol': [3350], '(106': [3351], 'ml–1)': [3353], 'incubated': [3355, 3387, 3837, 4380], '4': [3357], 'overnight.': [3359], 'cold': [3364], 'phosphate-buffered': [3365, 3372], 'saline,': [3366], 'saline': [3373], 'RNase': [3384], '45': [3392], 'min.': [3393], 'Detector': [3394], 'FL2-A': [3395], 'AmpGain': [3398], 'value': [3399], '1.75': [3401], 'used.': [3403], 'Analysis—Total': [3405], '(bloodstream': [3417], 'form)': [3418, 3423], '(procyclic': [3422], 'absence': [3429, 4138], '∼3': [3438], 'RNeasy': [3446], 'isolation': [3448], 'kit': [3449], '(Qiagen).': [3450], 'electrophoresed': [3457], 'formaldehyde': [3459], 'gels': [3460], 'blotted': [3462], 'according': [3463], '41Sambrook': [3466], 'Russell': [3468], 'D.W.': [3469], 'Molecular': [3470], 'Cloning:': [3471], 'Laboratory': [3473, 3480], 'Manual.': [3474], '3rd': [3475], 'Ed.': [3476], 'Cold': [3477, 3482], 'Spring': [3478, 3483], 'Harbor': [3479], 'Press,': [3481], 'Harbor,': [3484], 'NY2001Google': [3485], 'Scholar.': [3486], 'Northern': [3487], 'blots': [3488], 'hybridized': [3490], 'probes': [3492], 'radiolabeled': [3493], 'random': [3495], 'priming': [3496], 'Megaprime': [3499], 'labeling': [3501], 'system': [3502, 3824], '(Amersham': [3503], 'Biosciences).': [3504], 'probe': [3506, 3520, 3545, 3569, 3577, 3601], '719-bp': [3511], 'SalI/NotI': [3512], 'plasmid': [3517], '(Clontech).': [3518], '800-bp': [3527], 'corresponding': [3533], 'positions': [3535], '122–925': [3536], 'sequence': [3539], 'X56762).': [3543], '600-bp': [3552], 'EcoRI/HindIII': [3553], 'cDNA.': [3559], '3K.': [3560], '700-bp': [3572], 'HindIII/EcoRI': [3573], 'fragment.': [3574], 'entire': [3580], 'CPT4': [3581], 'cDNA': [3582], '(42Rudenko': [3583], 'Bishop': [3585], 'Gottesdiener': [3587], 'der': [3590], 'Ploeg': [3591], 'L.H.': [3592], '8:': [3596], '4259-4263Google': [3597], 'expected': [3604], 'hybridize': [3606], 'EP': [3612], 'GPEET': [3614], 'variants.': [3616], 'Quantitation': [3617], 'PhosphorImager.': [3623], 'Results': [3626], 'Marked': [3632], 'Silent': [3633, 4322], 'ESs—We': [3634], 'inactivated': [3648], 'As': [3654, 3736, 3933, 4512], 'silent,': [3659], 'us': [3663, 3761], 'assay': [3665, 3823], 'disruption': [3667, 3889], 'machinery.': [3672], 'linked': [3679], '(Fig.': [3707, 3778, 3803, 4004, 4099, 4181, 4478], '1A).': [3708], 'located': [3719, 3748], 'modified': [3738], 'contains': [3744], 'promoter,': [3756], 'screen': [3763, 3852], 'reactivation': [3765], 'strain': [3774, 3843], '221GP1(VO2+)': [3777, 3811, 3841, 4464], '1B).': [3779], 'more': [3790, 3948, 4173], 'than': [3791, 3794, 3952, 4174, 4197], '1000-fold': [3792], 'brighter': [3793], 'background,': [3795], 'allowing': [3796], 'very': [3800, 3819, 4164, 4471], 'easily': [3801], 'detected': [3802], '1C).': [3804], 'provided': [3817], 'measuring': [3826, 4347], 'change': [3828], 'First,': [3863], 'tested': [3865], 'histone': [3867], 'deacetylase': [3868], 'generally': [3873], 'causes': [3874], 'wide': [3882], 'experimental': [3885], 'systems': [3886], 'due': [3887], '43Yoshida': [3896], 'Horinouchi': [3898], 'Beppu': [3900], 'BioEssays.': [3902], '17:': [3904], '423-430Google': [3905], 'suppressed': [3910], 'detectable': [3920, 4275], '(result': [3930, 4354], 'shown).': [3932], 'surprising.': [3982], 'did': [3986, 4003, 4219], 'cause': [3988], 'ESs,': [3992], 'modification': [4000, 4109, 4141, 4301], '2).': [4005, 4100, 4182, 4479], 'Effective': [4006], 'high': [4011, 4165], 'levels': [4012, 4166, 4497], 'bulky': [4031], 'adduct': [4033], '(44van': [4036], 'Vaart': [4038], 'Belderbos': [4040], 'Jong': [4043], 'Sneeuw': [4045], 'K.C.': [4046], 'Majoor': [4047], 'Bartelink': [4049], 'A.C.': [4052], 'Cancer.': [4055], '160-166Google': [4058], 'methylates': [4062], '(45Bignami': [4064], "O'Driscoll": [4066], 'Aquilina': [4068], 'Karran': [4070], 'Mutat.': [4072], '462:': [4075], '71-82Google': [4076], 'Treatment': [4078, 4101, 4215, 4226, 4458], 'up': [4091], '40%': [4093], 'thymidine': [4114], 'dimers.': [4115], 'effective': [4120, 4144], 'intercalating': [4130], 'agent': [4131], 'bromide.': [4133], 'inducing': [4146], 'transcript.': [4150], 'up-regulation,': [4171], '50%': [4175], 'induced': [4189], 'rather': [4196], 'drugs': [4218], 'significant': [4223], '(46Fairlamb': [4232], 'A.H.': [4233], 'I.B.': [4235], '1980;': [4239, 4402], '1:': [4240], '315-333Google': [4241], 'ornithine': [4245], 'decarboxylase': [4246], '47Phillips': [4259], 'M.A.': [4260], 'Coffino': [4261], 'Wang': [4263, 4449], 'C.C.': [4264, 4450], '262:': [4269], '8721-8727Google': [4270], '(see': [4291, 4503], '"Experimental': [4292], 'Procedures"': [4293], 'details).': [4295], 'It': [4296], 'therefore': [4298], 'likely': [4299], 'key': [4309], 'Correlates': [4324], 'Block': [4327], 'Phase—Treatment': [4330], 'agents': [4336], 'incorporation': [4348], 'BrdUrd': [4350], 'shown)': [4356], '(48Woodward': [4357], '49-57Google': [4366], 'introducing': [4376], 'damage,': [4378], 'binds': [4389], 'inhibits': [4391], 'α': [4395], '(49Pedrali-Noy': [4396], 'Spadari': [4398], 'Virol.': [4401], '457-464Google': [4404], '50Sheaff': [4406], 'Ilsley': [4408], 'Kuchta': [4410], 'Biochemistry.': [4412], '30:': [4414], '8590-8597Google': [4415], 'stall': [4423], 'G1/S': [4427], 'transition': [4429], '51Mutomba': [4447], '1996;': [4454], '80:': [4455], '89-102Google': [4456], '30': [4466], 'μm': [4467], 'striking': [4472], 'Almost': [4480], 'expressed': [4485], '20%': [4489], '(dark': [4498], 'bar': [4499], 'Fig.': [4501, 4504], '2)': [4502], '1C': [4505], 'description': [4507], 'gates': [4510], 'used).': [4511], 'if': [4532, 4538], 'stalled': [4542], 'G1/G0': [4545], 'cycle.': [4550], 'inhibited': [4554], 'stumpy': [4556], 'bruc': [4559]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2131249903', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2025-01-12T09:41:58.490790', 'created_date': '2016-06-24'}