Publication Information

{'id': 'https://openalex.org/W2130677026', 'doi': 'https://doi.org/10.1002/jcph.573', 'title': 'Effects of enzastaurin and its metabolites on the QT interval in cancer patients', 'display_name': 'Effects of enzastaurin and its metabolites on the QT interval in cancer patients', 'publication_year': 2015, 'publication_date': '2015-06-20', 'ids': {'openalex': 'https://openalex.org/W2130677026', 'doi': 'https://doi.org/10.1002/jcph.573', 'mag': '2130677026', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26096682'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jcph.573', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S146237847', 'display_name': 'The Journal of Clinical Pharmacology', 'issn_l': '0091-2700', 'issn': ['0091-2700', '1552-4604'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5020714611', 'display_name': 'Pamela A. Welch', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I168537998', 'display_name': 'Eli Lilly (United States)', 'ror': 'https://ror.org/01qat3289', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I168537998']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Pamela A. Welch', 'raw_affiliation_strings': ["Pamela A. Welch's work on this article was performed while employed by Eli Lilly and Company, Indianapolis, IN, USA."], 'affiliations': [{'raw_affiliation_string': "Pamela A. Welch's work on this article was performed while employed by Eli Lilly and Company, Indianapolis, IN, USA.", 'institution_ids': ['https://openalex.org/I168537998']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113602441', 'display_name': 'Wee Teck Ng', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I168537998', 'display_name': 'Eli Lilly (United States)', 'ror': 'https://ror.org/01qat3289', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I168537998']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wee Teck Ng', 'raw_affiliation_strings': ['Eli Lilly and Company; Indianapolis, IN USA.'], 'affiliations': [{'raw_affiliation_string': 'Eli Lilly and Company; Indianapolis, IN USA.', 'institution_ids': ['https://openalex.org/I168537998']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012662423', 'display_name': 'Christelle Darstein', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1283582996', 'display_name': 'Novartis (Switzerland)', 'ror': 'https://ror.org/02f9zrr09', 'country_code': 'CH', 'type': 'company', 'lineage': ['https://openalex.org/I1283582996']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Christelle L. Darstein', 'raw_affiliation_strings': ['Novartis Pharma AG, Postfach, Basel, Switzerland;'], 'affiliations': [{'raw_affiliation_string': 'Novartis Pharma AG, Postfach, Basel, Switzerland;', 'institution_ids': ['https://openalex.org/I1283582996']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022619396', 'display_name': 'Luna Musib', 'orcid': 'https://orcid.org/0000-0002-6476-7919'}, 'institutions': [{'id': 'https://openalex.org/I183934855', 'display_name': 'Genentech', 'ror': 'https://ror.org/04gndp242', 'country_code': None, 'type': 'company', 'lineage': ['https://openalex.org/I118019719', 'https://openalex.org/I129302853', 'https://openalex.org/I183934855']}], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Luna Musib', 'raw_affiliation_strings': ['Genentech Inc.; San Francisco CA USA'], 'affiliations': [{'raw_affiliation_string': 'Genentech Inc.; San Francisco CA USA', 'institution_ids': ['https://openalex.org/I183934855']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5034014576', 'display_name': 'Thierry Lesimple', 'orcid': 'https://orcid.org/0000-0002-1360-5135'}, 'institutions': [{'id': 'https://openalex.org/I4210158359', 'display_name': 'Onco Lille', 'ror': 'https://ror.org/059091v77', 'country_code': 'FR', 'type': 'other', 'lineage': ['https://openalex.org/I4210158359']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Thierry Lesimple', 'raw_affiliation_strings': ['Comprehensive Cancer Center and Biotrial, Rennes, France.'], 'affiliations': [{'raw_affiliation_string': 'Comprehensive Cancer Center and Biotrial, Rennes, France.', 'institution_ids': ['https://openalex.org/I4210158359']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3760, 'currency': 'USD', 'value_usd': 3760, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.218, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.616444, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 73, 'max': 76}, 'biblio': {'volume': '56', 'issue': '1', 'first_page': '101', 'last_page': '108'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10217', 'display_name': 'Cardiac electrophysiology and arrhythmias', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10217', 'display_name': 'Cardiac electrophysiology and arrhythmias', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 0.9966, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10493', 'display_name': 'Ion channel regulation and function', 'score': 0.9939, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/torsades-de-pointes', 'display_name': 'Torsades de pointes', 'score': 0.57183504}, {'id': 'https://openalex.org/keywords/dofetilide', 'display_name': 'Dofetilide', 'score': 0.5625445}, {'id': 'https://openalex.org/keywords/clinical-pharmacology', 'display_name': 'Clinical Pharmacology', 'score': 0.452815}], 'concepts': [{'id': 'https://openalex.org/C118441451', 'wikidata': 'https://www.wikidata.org/wiki/Q12074763', 'display_name': 'QT interval', 'level': 2, 'score': 0.86481464}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.7131769}, {'id': 'https://openalex.org/C22979827', 'wikidata': 'https://www.wikidata.org/wiki/Q5137311', 'display_name': 'Cmax', 'level': 3, 'score': 0.6167012}, {'id': 'https://openalex.org/C2780486423', 'wikidata': 'https://www.wikidata.org/wiki/Q1625433', 'display_name': 'Torsades de pointes', 'level': 3, 'score': 0.57183504}, {'id': 'https://openalex.org/C2777796741', 'wikidata': 'https://www.wikidata.org/wiki/Q3712521', 'display_name': 'Dofetilide', 'level': 3, 'score': 0.5625445}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.5505156}, {'id': 'https://openalex.org/C112705442', 'wikidata': 'https://www.wikidata.org/wiki/Q323936', 'display_name': 'Pharmacokinetics', 'level': 2, 'score': 0.4893972}, {'id': 'https://openalex.org/C2778836808', 'wikidata': 'https://www.wikidata.org/wiki/Q424940', 'display_name': 'Moxifloxacin', 'level': 3, 'score': 0.47922355}, {'id': 'https://openalex.org/C63433958', 'wikidata': 'https://www.wikidata.org/wiki/Q1774688', 'display_name': 'Clinical pharmacology', 'level': 2, 'score': 0.452815}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.40558186}, {'id': 'https://openalex.org/C164705383', 'wikidata': 'https://www.wikidata.org/wiki/Q10379', 'display_name': 'Cardiology', 'level': 1, 'score': 0.3895783}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.10903603}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D008133', 'descriptor_name': 'Long QT Syndrome', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D004562', 'descriptor_name': 'Electrocardiography', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004562', 'descriptor_name': 'Electrocardiography', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006339', 'descriptor_name': 'Heart Rate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006339', 'descriptor_name': 'Heart Rate', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D008133', 'descriptor_name': 'Long QT Syndrome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008133', 'descriptor_name': 'Long QT Syndrome', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D008133', 'descriptor_name': 'Long QT Syndrome', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jcph.573', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S146237847', 'display_name': 'The Journal of Clinical Pharmacology', 'issn_l': '0091-2700', 'issn': ['0091-2700', '1552-4604'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26096682', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.77, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 11, 'referenced_works': ['https://openalex.org/W1440956116', 'https://openalex.org/W1981612300', 'https://openalex.org/W1985880028', 'https://openalex.org/W1989374274', 'https://openalex.org/W2010293399', 'https://openalex.org/W2045907202', 'https://openalex.org/W2093070825', 'https://openalex.org/W2096104621', 'https://openalex.org/W2126372596', 'https://openalex.org/W2136770337', 'https://openalex.org/W2172187886'], 'related_works': ['https://openalex.org/W3029715406', 'https://openalex.org/W2325410506', 'https://openalex.org/W2130677026', 'https://openalex.org/W2075818984', 'https://openalex.org/W2060751623', 'https://openalex.org/W2027718105', 'https://openalex.org/W1987751198', 'https://openalex.org/W1971410069', 'https://openalex.org/W1823862173', 'https://openalex.org/W1538383751'], 'abstract_inverted_index': {'Preclinical': [0], 'and': [1, 89, 92, 106, 135, 157, 190, 194], 'interim': [2], 'results': [3], 'from': [4, 51, 198], 'a': [5, 27, 70, 85, 126], 'clinical': [6, 53], 'pharmacology': [7, 54], 'study': [8], 'in': [9, 125], 'patients': [10, 58], 'with': [11, 59], 'cancer': [12, 60], 'indicated': [13], 'that': [14, 122], 'enzastaurin': [15, 35, 91, 105, 123, 140, 189], 'might': [16], 'have': [17], 'the': [18, 22, 32, 37, 43, 131, 149, 176], 'potential': [19], 'to': [20, 114], 'prolong': [21], 'QT.': [23], 'Rather': [24], 'than': [25], 'undertake': [26], 'formal': [28], 'thorough': [29], 'QT': [30, 38, 44], 'study,': [31], 'effect': [33], 'of': [34, 67, 104, 130, 146, 173], 'on': [36], 'was': [39, 76, 162, 180], 'assessed': [40], 'by': [41], 'combining': [42], 'corrected': [45], 'for': [46, 188], 'heart': [47], 'rate': [48], '(QTc)': [49], 'intervals': [50], '3': [52], 'studies': [55], 'totaling': [56], '85': [57], 'receiving': [61], 'multiple': [62], 'therapeutic': [63, 134], 'or': [64], 'supratherapeutic': [65, 136], 'doses': [66], 'enzastaurin.': [68], 'Neither': [69], 'placebo': [71], 'nor': [72], 'an': [73, 139, 169], 'active': [74, 95], 'control': [75], 'used.': [77], 'Serial,': [78], 'replicate,': [79], 'time-matched': [80], 'electrocardiograms': [81], 'were': [82, 108, 192], 'collected': [83], 'during': [84], 'no-drug': [86], 'baseline': [87], 'day': [88], 'when': [90], 'its': [93, 158], 'major': [94], 'metabolite,': [96], 'LSN326020,': [97], 'had': [98], 'achieved': [99], 'steady': [100], 'state.': [101], 'Plasma': [102], 'concentrations': [103], 'LSN326020': [107, 170, 191], 'determined': [109], 'at': [110, 133, 168], 'each': [111], 'electrocardiogram': [112], 'point': [113], 'enable': [115], 'concentration-QT': [116], 'analyses.': [117], 'The': [118, 185], 'cross-study': [119], 'analysis': [120], 'showed': [121], 'resulted': [124], 'statistically': [127, 195], 'significant': [128], 'prolongation': [129], 'QTc': [132, 151], 'doses.': [137], 'At': [138], 'maximum': [141], 'plasma': [142], 'concentration': [143], '(Cmax': [144], ')': [145], '3660': [147], 'nmol/L,': [148, 175], 'predicted': [150, 177], 'using': [152], "Fridericia's": [153], 'formula': [154], '(QTcF)': [155], 'interval': [156, 161, 179], '90%': [159], 'confidence': [160], '17.72': [163], 'milliseconds': [164, 182], '(16.52-18.92': [165], 'milliseconds).': [166, 184], 'Likewise,': [167], 'Cmax': [171], 'value': [172], '1718': [174], 'QTcF': [178], '20.23': [181], '(18.72-21.74': [183], 'concentration-QTcF': [186], 'slopes': [187], 'positive': [193], 'significantly': [196], 'different': [197], 'zero': [199], '(all': [200], 'P': [201], '<': [202], '.05).': [203]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2130677026', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}], 'updated_date': '2024-12-10T11:16:57.557751', 'created_date': '2016-06-24'}