Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2130463293', 'doi': 'https://doi.org/10.1002/bmc.266', 'title': 'Binding of low molecular mass compounds to proteins studied by liquid chromatographic techniques', 'display_name': 'Binding of low molecular mass compounds to proteins studied by liquid chromatographic techniques', 'publication_year': 2003, 'publication_date': '2003-07-22', 'ids': {'openalex': 'https://openalex.org/W2130463293', 'doi': 'https://doi.org/10.1002/bmc.266', 'mag': '2130463293', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/13680844'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/bmc.266', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S123979729', 'display_name': 'Biomedical Chromatography', 'issn_l': '0269-3879', 'issn': ['0269-3879', '1099-0801'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5003720821', 'display_name': 'Tibor Cserháti', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I80251312', 'display_name': 'HUN-REN Research Centre for Natural Sciences', 'ror': 'https://ror.org/03zwxja46', 'country_code': 'HU', 'type': 'facility', 'lineage': ['https://openalex.org/I4387152226', 'https://openalex.org/I80251312']}], 'countries': ['HU'], 'is_corresponding': True, 'raw_author_name': 'Tibor Cserháti', 'raw_affiliation_strings': ['Institute of Chemistry, Chemical Research Center, Hungarian Academy of Sciences, PO Box 17, 1525 Budapest, Hungary'], 'affiliations': [{'raw_affiliation_string': 'Institute of Chemistry, Chemical Research Center, Hungarian Academy of Sciences, PO Box 17, 1525 Budapest, Hungary', 'institution_ids': ['https://openalex.org/I80251312']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032554760', 'display_name': 'Esther Forgács', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I80251312', 'display_name': 'HUN-REN Research Centre for Natural Sciences', 'ror': 'https://ror.org/03zwxja46', 'country_code': 'HU', 'type': 'facility', 'lineage': ['https://openalex.org/I4387152226', 'https://openalex.org/I80251312']}], 'countries': ['HU'], 'is_corresponding': False, 'raw_author_name': 'Esther Forgács', 'raw_affiliation_strings': ['Institute of Chemistry, Chemical Research Center, Hungarian Academy of Sciences, PO Box 17, 1525 Budapest, Hungary'], 'affiliations': [{'raw_affiliation_string': 'Institute of Chemistry, Chemical Research Center, Hungarian Academy of Sciences, PO Box 17, 1525 Budapest, Hungary', 'institution_ids': ['https://openalex.org/I80251312']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049288308', 'display_name': 'Z. Deyl', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210166371', 'display_name': 'Czech Academy of Sciences, Institute of Physiology', 'ror': 'https://ror.org/05xw0ep96', 'country_code': 'CZ', 'type': 'facility', 'lineage': ['https://openalex.org/I202391551', 'https://openalex.org/I4210166371']}, {'id': 'https://openalex.org/I202391551', 'display_name': 'Czech Academy of Sciences', 'ror': 'https://ror.org/053avzc18', 'country_code': 'CZ', 'type': 'government', 'lineage': ['https://openalex.org/I202391551']}], 'countries': ['CZ'], 'is_corresponding': False, 'raw_author_name': 'Zdenek Deyl', 'raw_affiliation_strings': ['Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic'], 'affiliations': [{'raw_affiliation_string': 'Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic', 'institution_ids': ['https://openalex.org/I4210166371', 'https://openalex.org/I202391551']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002194455', 'display_name': 'Ivan Mikšı́k', 'orcid': 'https://orcid.org/0000-0001-5190-1827'}, 'institutions': [{'id': 'https://openalex.org/I202391551', 'display_name': 'Czech Academy of Sciences', 'ror': 'https://ror.org/053avzc18', 'country_code': 'CZ', 'type': 'government', 'lineage': ['https://openalex.org/I202391551']}, {'id': 'https://openalex.org/I4210166371', 'display_name': 'Czech Academy of Sciences, Institute of Physiology', 'ror': 'https://ror.org/05xw0ep96', 'country_code': 'CZ', 'type': 'facility', 'lineage': ['https://openalex.org/I202391551', 'https://openalex.org/I4210166371']}], 'countries': ['CZ'], 'is_corresponding': False, 'raw_author_name': 'Iran Miksik', 'raw_affiliation_strings': ['Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic'], 'affiliations': [{'raw_affiliation_string': 'Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic', 'institution_ids': ['https://openalex.org/I202391551', 'https://openalex.org/I4210166371']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5055690721', 'display_name': 'Adam Echardt', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I202391551', 'display_name': 'Czech Academy of Sciences', 'ror': 'https://ror.org/053avzc18', 'country_code': 'CZ', 'type': 'government', 'lineage': ['https://openalex.org/I202391551']}, {'id': 'https://openalex.org/I4210166371', 'display_name': 'Czech Academy of Sciences, Institute of Physiology', 'ror': 'https://ror.org/05xw0ep96', 'country_code': 'CZ', 'type': 'facility', 'lineage': ['https://openalex.org/I202391551', 'https://openalex.org/I4210166371']}], 'countries': ['CZ'], 'is_corresponding': False, 'raw_author_name': 'Adam Echardt', 'raw_affiliation_strings': ['Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic'], 'affiliations': [{'raw_affiliation_string': 'Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic', 'institution_ids': ['https://openalex.org/I202391551', 'https://openalex.org/I4210166371']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5003720821'], 'corresponding_institution_ids': ['https://openalex.org/I80251312'], 'apc_list': {'value': 3550, 'currency': 'USD', 'value_usd': 3550, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.199, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.423254, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 67, 'max': 70}, 'biblio': {'volume': '17', 'issue': '6', 'first_page': '353', 'last_page': '360'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10908', 'display_name': 'Chiral Separation in Chromatography', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/1607', 'display_name': 'Spectroscopy'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10908', 'display_name': 'Chiral Separation in Chromatography', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/1607', 'display_name': 'Spectroscopy'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10211', 'display_name': 'Computational Methods in Drug Discovery', 'score': 0.9966, 'subfield': {'id': 'https://openalex.org/subfields/1703', 'display_name': 'Computational Theory and Mathematics'}, 'field': {'id': 'https://openalex.org/fields/17', 'display_name': 'Computer Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11124', 'display_name': 'Protein Aggregation and Biopharmaceutical Stability', 'score': 0.9918, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/liquid-chromatography', 'display_name': 'Liquid Chromatography', 'score': 0.587462}, {'id': 'https://openalex.org/keywords/hydrophilic-interaction-chromatography-(hilic)', 'display_name': 'Hydrophilic Interaction Chromatography (HILIC)', 'score': 0.565721}, {'id': 'https://openalex.org/keywords/high-performance-liquid-chromatography-(hplc)', 'display_name': 'High-Performance Liquid Chromatography (HPLC)', 'score': 0.565473}, {'id': 'https://openalex.org/keywords/chromatography', 'display_name': 'Chromatography', 'score': 0.555671}, {'id': 'https://openalex.org/keywords/two-dimensional-chromatography', 'display_name': 'Two-Dimensional Chromatography', 'score': 0.541049}, {'id': 'https://openalex.org/keywords/liquid-phase', 'display_name': 'Liquid phase', 'score': 0.43045175}], 'concepts': [{'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.90937555}, {'id': 'https://openalex.org/C43617362', 'wikidata': 'https://www.wikidata.org/wiki/Q170050', 'display_name': 'Chromatography', 'level': 1, 'score': 0.80607176}, {'id': 'https://openalex.org/C117760992', 'wikidata': 'https://www.wikidata.org/wiki/Q389137', 'display_name': 'Ion exchange', 'level': 3, 'score': 0.48804274}, {'id': 'https://openalex.org/C193363816', 'wikidata': 'https://www.wikidata.org/wiki/Q1617865', 'display_name': 'Size-exclusion chromatography', 'level': 3, 'score': 0.4559683}, {'id': 'https://openalex.org/C3020315061', 'wikidata': 'https://www.wikidata.org/wiki/Q11435', 'display_name': 'Liquid phase', 'level': 2, 'score': 0.43045175}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.28199014}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.19013709}, {'id': 'https://openalex.org/C145148216', 'wikidata': 'https://www.wikidata.org/wiki/Q36496', 'display_name': 'Ion', 'level': 2, 'score': 0.18280432}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C97355855', 'wikidata': 'https://www.wikidata.org/wiki/Q11473', 'display_name': 'Thermodynamics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002851', 'descriptor_name': 'Chromatography, High Pressure Liquid', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002851', 'descriptor_name': 'Chromatography, High Pressure Liquid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004785', 'descriptor_name': 'Environmental Pollutants', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004785', 'descriptor_name': 'Environmental Pollutants', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008970', 'descriptor_name': 'Molecular Weight', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/bmc.266', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S123979729', 'display_name': 'Biomedical Chromatography', 'issn_l': '0269-3879', 'issn': ['0269-3879', '1099-0801'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/13680844', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Reduced inequalities', 'id': 'https://metadata.un.org/sdg/10', 'score': 0.75}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 85, 'referenced_works': ['https://openalex.org/W1520359022', 'https://openalex.org/W1523550130', 'https://openalex.org/W157808733', 'https://openalex.org/W160221199', 'https://openalex.org/W1626958299', 'https://openalex.org/W1969028606', 'https://openalex.org/W1971054145', 'https://openalex.org/W1971427919', 'https://openalex.org/W1972633208', 'https://openalex.org/W1972772839', 'https://openalex.org/W1977844334', 'https://openalex.org/W1991524700', 'https://openalex.org/W1995948261', 'https://openalex.org/W1999165782', 'https://openalex.org/W1999879558', 'https://openalex.org/W2001107360', 'https://openalex.org/W2001257630', 'https://openalex.org/W2004534398', 'https://openalex.org/W2007412856', 'https://openalex.org/W2008134353', 'https://openalex.org/W2009252359', 'https://openalex.org/W2014507909', 'https://openalex.org/W2017158019', 'https://openalex.org/W2017258822', 'https://openalex.org/W2019890274', 'https://openalex.org/W2021312311', 'https://openalex.org/W2022160549', 'https://openalex.org/W2024181345', 'https://openalex.org/W2025994981', 'https://openalex.org/W2030730476', 'https://openalex.org/W2034458285', 'https://openalex.org/W2036131177', 'https://openalex.org/W2036377111', 'https://openalex.org/W2038213581', 'https://openalex.org/W2038433288', 'https://openalex.org/W2039129189', 'https://openalex.org/W2042127921', 'https://openalex.org/W2042586120', 'https://openalex.org/W2042738756', 'https://openalex.org/W2043778165', 'https://openalex.org/W2046305620', 'https://openalex.org/W2047497853', 'https://openalex.org/W2048290610', 'https://openalex.org/W2049137758', 'https://openalex.org/W2059468091', 'https://openalex.org/W2061815276', 'https://openalex.org/W2073582379', 'https://openalex.org/W2076058809', 'https://openalex.org/W2080483822', 'https://openalex.org/W2081497192', 'https://openalex.org/W2081551596', 'https://openalex.org/W2086094814', 'https://openalex.org/W2089101015', 'https://openalex.org/W2091918339', 'https://openalex.org/W2094181196', 'https://openalex.org/W2107839779', 'https://openalex.org/W2108176208', 'https://openalex.org/W2108937569', 'https://openalex.org/W2109241894', 'https://openalex.org/W2109791983', 'https://openalex.org/W2125715557', 'https://openalex.org/W2127884342', 'https://openalex.org/W2138408503', 'https://openalex.org/W2142456549', 'https://openalex.org/W2144823092', 'https://openalex.org/W2146226667', 'https://openalex.org/W2155210601', 'https://openalex.org/W2161725950', 'https://openalex.org/W2166827931', 'https://openalex.org/W2171314409', 'https://openalex.org/W2171774972', 'https://openalex.org/W228375438', 'https://openalex.org/W2327230697', 'https://openalex.org/W3011481558', 'https://openalex.org/W3021421549', 'https://openalex.org/W3027573305', 'https://openalex.org/W3147339645', 'https://openalex.org/W4235159894', 'https://openalex.org/W4238271343', 'https://openalex.org/W4241290074', 'https://openalex.org/W4246557055', 'https://openalex.org/W4252171081', 'https://openalex.org/W4299307213', 'https://openalex.org/W66986359', 'https://openalex.org/W97183258'], 'related_works': ['https://openalex.org/W4387497383', 'https://openalex.org/W4229748205', 'https://openalex.org/W2948807893', 'https://openalex.org/W2778153218', 'https://openalex.org/W2748952813', 'https://openalex.org/W2527526854', 'https://openalex.org/W2062208111', 'https://openalex.org/W1986764834', 'https://openalex.org/W1976181487', 'https://openalex.org/W1531601525'], 'abstract_inverted_index': {'Abstract': [0], 'The': [1], 'newest': [2], 'achievements': [3], 'in': [4, 46], 'the': [5, 25, 28, 32], 'application': [6], 'of': [7, 27, 31, 34, 44], 'miscellaneous': [8], 'liquid': [9, 19], 'chromatographic': [10], 'techniques': [11], 'such': [12], 'as': [13], 'size‐exclusion,': [14], 'ion‐exchange': [15], 'and': [16, 21, 40, 48, 56], 'reversed‐phase': [17], 'high‐performance': [18], 'chromatography,': [20], 'thin‐layer': [22], 'chromatography': [23], 'for': [24], 'elucidation': [26], 'various': [29], 'aspects': [30], 'binding': [33], 'ligands': [35], 'to': [36], 'proteins': [37], 'are': [38, 59], 'compiled': [39], 'briefly': [41], 'discussed.': [42], 'Examples': [43], 'employment': [45], 'pharmaceutical': [47], 'clinical': [49], 'chemistry,': [50], 'drug': [51], 'design,': [52], 'enzyme': [53], 'kinetic': [54], 'studies': [55], 'environmental': [57], 'protection': [58], 'presented.': [60], 'Copyright': [61], '©': [62], '2003': [63], 'John': [64], 'Wiley': [65], '&': [66], 'Sons,': [67], 'Ltd.': [68]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2130463293', 'counts_by_year': [], 'updated_date': '2024-08-28T15:54:53.516100', 'created_date': '2016-06-24'}