Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2129912039', 'doi': 'https://doi.org/10.1016/s0014-5793(03)01447-9', 'title': 'Microcystin‐LR and okadaic acid‐induced cellular effects: a dualistic response', 'display_name': 'Microcystin‐LR and okadaic acid‐induced cellular effects: a dualistic response', 'publication_year': 2003, 'publication_date': '2003-12-13', 'ids': {'openalex': 'https://openalex.org/W2129912039', 'doi': 'https://doi.org/10.1016/s0014-5793(03)01447-9', 'mag': '2129912039', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/14741332'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0014-5793(03)01447-9', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104830714', 'display_name': 'FEBS Letters', 'issn_l': '0014-5793', 'issn': ['0014-5793', '1873-3468'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5022211393', 'display_name': 'Michelle M. Gehringer', 'orcid': 'https://orcid.org/0000-0002-4982-2465'}, 'institutions': [{'id': 'https://openalex.org/I31746571', 'display_name': 'UNSW Sydney', 'ror': 'https://ror.org/03r8z3t63', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I31746571']}], 'countries': ['AU'], 'is_corresponding': True, 'raw_author_name': 'Michelle M Gehringer', 'raw_affiliation_strings': ['School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia. [email protected]'], 'affiliations': [{'raw_affiliation_string': 'School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia. [email protected]', 'institution_ids': ['https://openalex.org/I31746571']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5022211393'], 'corresponding_institution_ids': ['https://openalex.org/I31746571'], 'apc_list': {'value': 3610, 'currency': 'USD', 'value_usd': 3610, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.033, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 273, 'citation_normalized_percentile': {'value': 0.685393, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '557', 'issue': '1-3', 'first_page': '1', 'last_page': '8'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10236', 'display_name': 'Eutrophication and Harmful Algal Blooms', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2304', 'display_name': 'Environmental Chemistry'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10236', 'display_name': 'Eutrophication and Harmful Algal Blooms', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2304', 'display_name': 'Environmental Chemistry'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T12832', 'display_name': 'Biological Soil Crusts and their Roles in Ecosystems', 'score': 0.9937, 'subfield': {'id': 'https://openalex.org/subfields/1105', 'display_name': 'Ecology, Evolution, Behavior and Systematics'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11985', 'display_name': 'Harmful Algal Blooms and Marine Toxins', 'score': 0.9873, 'subfield': {'id': 'https://openalex.org/subfields/2304', 'display_name': 'Environmental Chemistry'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/microcystin-lr', 'display_name': 'Microcystin-LR', 'score': 0.7600066}, {'id': 'https://openalex.org/keywords/hepatotoxin', 'display_name': 'Hepatotoxin', 'score': 0.7446177}, {'id': 'https://openalex.org/keywords/marine-toxin', 'display_name': 'Marine toxin', 'score': 0.5023265}, {'id': 'https://openalex.org/keywords/protein-phosphatase-1', 'display_name': 'Protein phosphatase 1', 'score': 0.500823}], 'concepts': [{'id': 'https://openalex.org/C2776953658', 'wikidata': 'https://www.wikidata.org/wiki/Q414042', 'display_name': 'Okadaic acid', 'level': 4, 'score': 0.9961555}, {'id': 'https://openalex.org/C389152', 'wikidata': 'https://www.wikidata.org/wiki/Q6593007', 'display_name': 'Protein phosphatase 2', 'level': 4, 'score': 0.8339132}, {'id': 'https://openalex.org/C2776414213', 'wikidata': 'https://www.wikidata.org/wiki/Q183290', 'display_name': 'Serine', 'level': 3, 'score': 0.76830244}, {'id': 'https://openalex.org/C2781226839', 'wikidata': 'https://www.wikidata.org/wiki/Q424720', 'display_name': 'Microcystin', 'level': 4, 'score': 0.76223445}, {'id': 'https://openalex.org/C2780299475', 'wikidata': 'https://www.wikidata.org/wiki/Q6839436', 'display_name': 'Microcystin-LR', 'level': 4, 'score': 0.7600066}, {'id': 'https://openalex.org/C149971331', 'wikidata': 'https://www.wikidata.org/wiki/Q1444355', 'display_name': 'Hepatotoxin', 'level': 3, 'score': 0.7446177}, {'id': 'https://openalex.org/C178666793', 'wikidata': 'https://www.wikidata.org/wiki/Q422476', 'display_name': 'Phosphatase', 'level': 3, 'score': 0.7406418}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.6177241}, {'id': 'https://openalex.org/C2775880066', 'wikidata': 'https://www.wikidata.org/wiki/Q186521', 'display_name': 'Threonine', 'level': 4, 'score': 0.59699583}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.59267163}, {'id': 'https://openalex.org/C2910844273', 'wikidata': 'https://www.wikidata.org/wiki/Q184651', 'display_name': 'Marine toxin', 'level': 3, 'score': 0.5023265}, {'id': 'https://openalex.org/C2779408958', 'wikidata': 'https://www.wikidata.org/wiki/Q7251492', 'display_name': 'Protein phosphatase 1', 'level': 4, 'score': 0.500823}, {'id': 'https://openalex.org/C2779669040', 'wikidata': 'https://www.wikidata.org/wiki/Q93315', 'display_name': 'Cyanobacteria', 'level': 3, 'score': 0.46845958}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.44137508}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.40028682}, {'id': 'https://openalex.org/C2777367657', 'wikidata': 'https://www.wikidata.org/wiki/Q184651', 'display_name': 'Toxin', 'level': 2, 'score': 0.18840373}, {'id': 'https://openalex.org/C29730261', 'wikidata': 'https://www.wikidata.org/wiki/Q274160', 'display_name': 'Toxicity', 'level': 2, 'score': 0.10904515}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001427', 'descriptor_name': 'Bacterial Toxins', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D019319', 'descriptor_name': 'Okadaic Acid', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D010456', 'descriptor_name': 'Peptides, Cyclic', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D010749', 'descriptor_name': 'Phosphoprotein Phosphatases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001427', 'descriptor_name': 'Bacterial Toxins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002455', 'descriptor_name': 'Cell Division', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002455', 'descriptor_name': 'Cell Division', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003599', 'descriptor_name': 'Cytoskeleton', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D003599', 'descriptor_name': 'Cytoskeleton', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D003599', 'descriptor_name': 'Cytoskeleton', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008387', 'descriptor_name': 'Marine Toxins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052998', 'descriptor_name': 'Microcystins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019319', 'descriptor_name': 'Okadaic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010456', 'descriptor_name': 'Peptides, Cyclic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010749', 'descriptor_name': 'Phosphoprotein Phosphatases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0014-5793(03)01447-9', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104830714', 'display_name': 'FEBS Letters', 'issn_l': '0014-5793', 'issn': ['0014-5793', '1873-3468'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/14741332', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/14', 'score': 0.76, 'display_name': 'Life below water'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 73, 'referenced_works': ['https://openalex.org/W1496832150', 'https://openalex.org/W1506485465', 'https://openalex.org/W1527047098', 'https://openalex.org/W1596483316', 'https://openalex.org/W1860058048', 'https://openalex.org/W1960573418', 'https://openalex.org/W1964000778', 'https://openalex.org/W1965718556', 'https://openalex.org/W1966266025', 'https://openalex.org/W1968627279', 'https://openalex.org/W1973122402', 'https://openalex.org/W1973210866', 'https://openalex.org/W1973936736', 'https://openalex.org/W1974882883', 'https://openalex.org/W1976974793', 'https://openalex.org/W1978431969', 'https://openalex.org/W1979378857', 'https://openalex.org/W1981436513', 'https://openalex.org/W1982157932', 'https://openalex.org/W1983225676', 'https://openalex.org/W1986879708', 'https://openalex.org/W1988228934', 'https://openalex.org/W1989911861', 'https://openalex.org/W1991256149', 'https://openalex.org/W1991494214', 'https://openalex.org/W1992620549', 'https://openalex.org/W1994260666', 'https://openalex.org/W1995903447', 'https://openalex.org/W1996218569', 'https://openalex.org/W1996892555', 'https://openalex.org/W2000211667', 'https://openalex.org/W2004775204', 'https://openalex.org/W2014465321', 'https://openalex.org/W2015058271', 'https://openalex.org/W2016354599', 'https://openalex.org/W2023016697', 'https://openalex.org/W2027222105', 'https://openalex.org/W2029190624', 'https://openalex.org/W2029195164', 'https://openalex.org/W2030524684', 'https://openalex.org/W2030544021', 'https://openalex.org/W2034395844', 'https://openalex.org/W2041241051', 'https://openalex.org/W2044388483', 'https://openalex.org/W2045940213', 'https://openalex.org/W2046543329', 'https://openalex.org/W2046724577', 'https://openalex.org/W2052677449', 'https://openalex.org/W2053466369', 'https://openalex.org/W2056074767', 'https://openalex.org/W2064248967', 'https://openalex.org/W2074525235', 'https://openalex.org/W2079640553', 'https://openalex.org/W2086429432', 'https://openalex.org/W2088119581', 'https://openalex.org/W2094994443', 'https://openalex.org/W2095018624', 'https://openalex.org/W2097092816', 'https://openalex.org/W2097202616', 'https://openalex.org/W2102089093', 'https://openalex.org/W2103965206', 'https://openalex.org/W2105333852', 'https://openalex.org/W2112683748', 'https://openalex.org/W2112965326', 'https://openalex.org/W2119759469', 'https://openalex.org/W2122585922', 'https://openalex.org/W2124913425', 'https://openalex.org/W2131487223', 'https://openalex.org/W2148802784', 'https://openalex.org/W2159173692', 'https://openalex.org/W2168941771', 'https://openalex.org/W2169591534', 'https://openalex.org/W2413562571'], 'related_works': ['https://openalex.org/W2129912039', 'https://openalex.org/W2102187012', 'https://openalex.org/W2092238659', 'https://openalex.org/W2090544745', 'https://openalex.org/W2084882053', 'https://openalex.org/W2064248967', 'https://openalex.org/W2058380781', 'https://openalex.org/W2046592161', 'https://openalex.org/W1992629736', 'https://openalex.org/W1978431969'], 'abstract_inverted_index': {'Microcystins,': [0], 'potent': [1, 43], 'heptapeptide': [2], 'hepatotoxins': [3], 'produced': [4], 'by': [5], 'certain': [6], 'bloom‐forming': [7], 'cyanobacteria,': [8], 'are': [9], 'strong': [10], 'protein': [11, 19, 32], 'phosphatase': [12], 'inhibitors.': [13], 'They': [14], 'covalently': [15], 'bind': [16], 'the': [17, 77, 81, 103], 'serine/threonine': [18], 'phosphatases': [20], '1': [21], 'and': [22, 25, 51, 68, 89, 94, 97], '2A': [23], '(PP1': [24], 'PP2A),': [26], 'thereby': [27], 'influencing': [28], 'regulation': [29], 'of': [30, 45, 49, 84, 87, 105], 'cellular': [31, 70], 'phosphorylation.': [33], 'The': [34], 'paralytic': [35], 'shellfish': [36], 'poison,': [37], 'okadaic': [38, 61, 106], 'acid,': [39], 'is': [40], 'also': [41], 'a': [42, 54], 'inhibitor': [44], 'these': [46], 'PPs.': [47], 'Inhibition': [48], 'PP1': [50, 88], 'PP2A': [52, 90], 'has': [53], 'dualistic': [55], 'effect': [56], 'on': [57, 80], 'cells': [58], 'exposed': [59], 'to': [60, 102], 'acid': [62], 'or': [63], 'microcystin‐LR,': [64], 'with': [65], 'both': [66, 91], 'apoptosis': [67], 'increased': [69], 'proliferation': [71], 'being': [72], 'reported.': [73], 'This': [74], 'review': [75], 'summarises': [76], 'existing': [78], 'data': [79], 'molecular': [82], 'effects': [83], 'microcystin‐LR': [85], 'inhibition': [86], 'in': [92, 95], 'vivo': [93], 'vitro,': [96], 'where': [98], 'possible,': [99], 'compares': [100], 'this': [101], 'action': [104], 'acid.': [107]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2129912039', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 10}, {'year': 2019, 'cited_by_count': 17}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 10}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 25}, {'year': 2014, 'cited_by_count': 14}, {'year': 2013, 'cited_by_count': 18}, {'year': 2012, 'cited_by_count': 23}], 'updated_date': '2024-09-10T02:54:45.530244', 'created_date': '2016-06-24'}