Publication Information

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'(4),': [522], 'whereas': [523, 563, 649, 858], 'others': [524, 564], '<50': [530], 'old': [532, 644], 'Women,': [534], 'however,': [535], 'incidence': [538, 658], 'pneumonia,': [540], 'sepsis,': [541, 549, 606], 'multiorgan': [543, 660], 'failure': [544], 'some': [550], '>80': [560], 'old,': [562], 'rates': [569], 'study': [575, 953, 1123], 'Schroeder': [577], 'colleagues': [579], '(reviewed': [580], 'reference': [582], '4)': [583], 'involving': [584], 'septic': [585], 'patients,': [586], 'demonstrated': [588], 'IL-10': [593], 'TNF-α': [596], 'levels.': [597], 'Fewer': [598], 'female': [599, 847, 1809], 'patients': [600], 'intensive': [602, 1673], 'care': [603, 1674], 'units': [604], 'developed': [605], 'although,': [607], 'sepsis': [609, 663, 1670, 1761], 'developed,': [610], '(11).': [621], 'Clinical': [622], 'burns': [630, 665], 'present': [631, 952, 1077], 'inconsistent': [632], 'evidence.': [633], 'ages': [641], '30–59': [642], 'mortality,': [648], '(4).In': [666], 'contrast': [667], 'studies,': [671, 845], 'consistently': [675, 824], 'females': [678, 742, 758, 761, 767, 827, 855, 882, 886, 930], 'do': [679], 'better.': [680], 'Protective': [681], 'administration': [685, 709], 'estrogen,': [687], 'vivo': [691, 728], 'left': [692], 'anterior': [693], 'descending': [694], '(LAD)': [695], 'coronary': [696], 'artery': [697], 'ischemia-reperfusion': [698, 1601], '(I/R)': [699], 'model,': [700], 'different': [705], 'animals': [706], 'Chronic': [708], 'provides': [712], 'protection': [713], 'I/R': [715, 739], 'injury': [716, 832, 1898], 'isolated': [718, 753], 'hearts': [719, 725], 'undergoing': [720, 726], 'global': [721, 749], 'ischemia': [722], 'LAD': [729, 738], 'obstruction.': [730], 'Estrogen': [731, 813, 1866], 'also': [732, 814], 'against': [734, 830, 1895], 'reperfusion-induced': [735], 'arrhythmias': [736], 'injury.': [740, 1441, 1602], 'Ovariectomized': [741], 'worse': [744], 'functional': [746, 888], 'recovery': [747, 889], 'I/R,': [750], 'heart,': [754], 'than': [755, 895, 1763], 'sham': [756], 'ovariectomized': [757, 760], 'estradiol.': [763], 'After': [764], 'burn': [765], 'injury,': [766], 'cytokine': [770, 1392, 2020, 2048, 2242, 2297], 'production': [771, 2021, 2186, 2243, 2298], 'function.': [775], 'Trauma-hemorrhage': [776], 'leads': [777], 'depressed': [779], 'depression': [784, 795, 818, 1318], 'severe': [787, 1669], 'males': [789, 1358, 1721], '(3,': [790], '12,': [791], '13).': [792], 'is,': [796], 'part,': [798], 'caused': [799, 819], 'testosterone': [801, 1632, 1972], '(1,': [802], '2),': [803], 'because': [804], 'both': [805], 'castration': [806], 'receptor': [808, 1092, 1264, 2292], 'blockade': [809], 'attenuated': [810], 'depression.': [812], 'prevented': [815], 'trauma-hemorrhage.Animal': [821], 'while': [833, 2191], 'A': [838], 'possible': [839], 'reason': [840], 'population': [848], 'controlled': [851], 'proestrous': [854, 896], 'used,': [857], 'heterogeneous': [863], 'population.': [864], 'underlying': [867], 'condition': [868], 'humans': [870], 'less': [872], 'uniform.': [873], 'Indeed,': [874], 'few': [876, 905], 'used': [880], 'diestrous': [881, 885], 'equivalent': [890], 'males,': [892], 'females.': [897], 'borne': [901], 'out': [902], 'fluctuates': [912], 'changes': [916, 1014], 'menstrual': [918], 'cycle.': [919], 'Thus': [920], 'know': [925], 'status': [928], 'future': [932], 'take': [936], 'into': [938], 'account': [939], 'produce': [941], 'consistent': [943], 'results.One': [944], 'incredibly': [947], 'novel': [948], 'aspects': [949], '(7)': [954, 1145], 'relates': [955], 'rapid': [958], 'signaling': [959, 974, 999, 1035, 1044, 1073, 1161, 1182, 1218, 1227, 1638], 'processing': [962], 'must': [964], 'occurred.': [966], 'nuclear': [970, 1006, 1016, 1084, 1157, 1189, 1199, 1256], 'transcription': [971, 1007, 1050, 1085, 1105, 1116, 1158, 1190, 1233, 1257, 1277, 1289], 'extracellular': [973, 1160], 'pathways': [975, 1162, 2378], 'regulated': [978, 1165], 'conventional': [980, 1167], 'steroid': [981, 1021, 1168, 1204], 'receptors': [982, 1169, 2040], '(SR),': [983, 1170], 'alpha': [987, 1174], 'beta': [989, 1176], 'receptors.': [991, 1178], 'We': [992], 'now': [993], 'appreciate': [994], 'SRs': [996, 1011, 1088, 1179, 1194, 1260], 'affect': [998, 1181], 'distinct': [1002, 1185], 'paths:': [1003, 1186], '1)': [1004, 1079, 1187, 1251], 'path,': [1008, 1037, 1191, 1220], 'whereby': [1009, 1038, 1192, 1221], 'activated': [1010, 1040, 1080, 1101, 1193, 1223, 1252, 1273], 'undergo': [1012, 1195], 'conformational': [1013, 1196], 'allowing': [1015, 1198], 'translocation': [1017], 'bind': [1019, 1202], 'response': [1022, 1205, 1438, 1599], 'elements': [1023, 1206], '(SREs)': [1024, 1207], 'target': [1026, 1209], 'genes;': [1027, 1210], 'and,': [1028], '2)': [1029, 1100, 1212, 1272], 'cytoplasmic': [1031, 1214], 'cell': [1033, 1216, 1976, 2044, 2185, 2296], 'membrane': [1034, 1217], '(mSR)': [1036, 1219], 'SR': [1041, 1110, 1224, 1283], 'influences': [1042, 1225], 'cyoplasmic': [1043, 1226], 'processes,': [1045, 1228], 'which': [1046, 1156, 1229], 'then': [1047, 1230], 'modulate': [1048, 1231], 'gene': [1049, 1232], 'three': [1052, 1066, 1235], 'potential': [1053, 1236], 'MAPK-mediated': [1054, 1237], '(Fig.': [1056], '1).': [1057], 'currently': [1059], 'appreciated': [1060], 'mSR': [1061, 1239], 'include': [1063], 'least': [1065], 'relevant': [1070], 'required': [1074, 1353], 'findings:': [1078], 'MAPK': [1081, 1102, 1253, 1274, 2201], 'activity': [1086, 1258], 'phosphorylating': [1090, 1262], 'coactivator': [1095, 1267], 'feed-forward': [1098, 1270], 'mechanism;': [1099, 1271], 'activates': [1103, 1275], 'cooperate': [1108, 1281], 'SREs;': [1112, 1285], '3)': [1114, 1287], 'mediated': [1115, 1288], 'genes': [1118, 1291], 'without': [1119, 1292], 'SREs.Indeed,': [1120], 'outstanding': [1122], 'brings': [1128], 'large': [1131], 'protection.': [1139], 'I': [1140], 'highly': [1141], 'recommend': [1142], 'readership': [1148], 'Journal.': [1151], 'Fig.': [1152], '1.Simplified': [1153], 'schematic': [1154], 'changes,': [1197], 'translocation,': [1200], 'mechanisms.': [1238], 'marked': [1242], 'numbered,': [1245], 'blue': [1246], 'bullets': [1247], 'figure:': [1250], '(TF)': [1279], 'SREs.': [1293], 'p-HSP,': [1294], 'phospho-heat': [1295], 'protein.Download': [1297], 'figureDownload': [1298], 'PowerPointREFERENCES1': [1299], 'Angele': [1300, 1335, 1371], 'MK,': [1301, 1336, 1372], 'Ayala': [1302, 1337, 1377, 1705, 1742], 'A,': [1303, 1338, 1378, 1412, 1621, 1706, 1743], 'Cioffi': [1304, 1341, 1379], 'WG,': [1305, 1342, 1380], 'Bland': [1306, 1343, 1381, 1515], 'KI,': [1307, 1344, 1382, 1516], 'IH.': [1310, 1347, 1385, 1519, 1709, 1750], 'Testosterone:': [1311], 'culprit': [1313], 'producing': [1315], 'splenocyte': [1316, 2330], 'hemorrhage.': [1321], 'Am': [1322, 1398, 1461, 1535, 1603, 1642], 'J': [1323, 1361, 1399, 1462, 1536, 1604, 1643], 'Physiol': [1324, 1326, 1400, 1402, 1463, 1467, 1537, 1541, 1605, 1644, 1647], 'Cell': [1325, 1401, 1941], '274:': [1327, 1468], 'C1530–C1536,': [1328], '1998.Link': [1329, 1470], '|': [1330, 1332, 1366, 1368, 1406, 1408, 1446, 1448, 1450, 1471, 1473, 1493, 1495, 1497, 1575, 1577, 1579, 1611, 1613, 1651, 1653, 1692, 1694, 1696, 1731, 1733, 1735, 1771, 1773, 1775, 1829, 1873, 1929, 1945, 1960, 2001, 2026, 2066, 2110, 2167, 2230, 2276, 2320, 2353, 2387], 'ISI': [1331, 1407, 1449, 1472, 1496, 1578, 1612, 1652, 1695, 1734, 1774], 'Google': [1333, 1369, 1409, 1451, 1474, 1498, 1580, 1614, 1654, 1697, 1736, 1776], 'Scholar2': [1334], 'Monfils': [1339], 'BA,': [1340], 'Testosterone': [1348], 'and/or': [1349], 'low': [1350], 'estradiol:': [1351], 'normally': [1352], 'harmful': [1355], 'immunologically': [1356], 'trauma-hemorrhage.': [1360, 1397], '44:': [1363], '78–85,': [1364], '1998.Crossref': [1365], 'PubMed': [1367, 1447, 1494, 1576, 1693, 1732, 1772], 'Scholar3': [1370], 'Knoferl': [1373], 'MW,': [1374, 1657, 1700, 1741], 'Schwacha': [1375, 1510], 'MG,': [1376, 1511], 'Sex': [1386, 1432, 1555, 1593, 2124], 'steroids': [1387], 'regulate': [1388], 'pro-': [1389], 'anti-inflammatory': [1391], 'release': [1393], 'macrophages': [1395, 2019, 2088, 2369], '277:': [1403], 'C35–C42,': [1404], '1999.Link': [1405], 'Scholar4': [1410], 'Kher': [1411, 1620], 'Wang': [1413, 1582, 1616], 'M,': [1414, 1583, 1617], 'Tsai': [1415, 1586, 1618], 'BM,': [1416, 1587, 1619], 'Pitcher': [1417], 'JM,': [1418], 'Greenbaum': [1419], 'ES,': [1420], 'Nagy': [1421], 'RD,': [1422], 'Patel': [1423], 'KM,': [1424], 'Wairiuko': [1425, 1624], 'GM,': [1426, 1625], 'Markel': [1427], 'TA,': [1428], 'Meldrum': [1430, 1453, 1588, 1591, 1627], 'DR.': [1431, 1454, 1592, 1628], 'Shock': [1442, 1956], '23:': [1443], '1–10,': [1444], '2005.Crossref': [1445, 1492], 'Scholar5': [1452], 'Tumor': [1455], 'necrosis': [1456, 2038], 'factor': [1457, 2039, 2046], 'heart.': [1460], 'Regul': [1464, 1538], 'Integr': [1465, 1539], 'Comp': [1466, 1540], 'R577–R595,': [1469], 'Scholar6': [1475], 'Mendelsohn': [1476], 'ME': [1477], 'Karas': [1479], 'RH.': [1480], 'Molecular': [1481, 1874, 1946, 1961, 2394], 'cellular': [1483], 'basis': [1484], 'differences.': [1488], 'Science': [1489], '308:': [1490], '1583–1587,': [1491], 'Scholar7': [1499], 'Szalay': [1500], 'L,': [1501, 1585], 'Shimizu': [1502], 'T,': [1503, 1505], 'Suzuki': [1504], 'Yu': [1506], 'HP,': [1507], 'Choudhry': [1508], 'MA,': [1509], 'Rue': [1512], 'Iii': [1513], 'LW,': [1514], 'Estradiol': [1520], 'improves': [1521, 2018], 'hepatic': [1524], 'trauma-hemorrhage:': [1527], 'enhanced': [1530], 'protein': [1533, 2135], 'expression.': [1534], '290:': [1542], 'R000–R000,': [1543], '2006.Google': [1544], 'Scholar8': [1545], 'Vaccarino': [1546], 'V,': [1547], 'Krumholz': [1548], 'HM,': [1549], 'Berkman': [1550], 'LF,': [1551], 'Horwitz': [1553], 'RI.': [1554], 'infarction.': [1561], 'Is': [1562], 'evidence': [1564], 'increased': [1567], 'women?': [1570], 'Circulation': [1571], '91:': [1572], '1861–1871,': [1573], '1995.Crossref': [1574], 'Scholar9': [1581], 'Baker': [1584, 1622], 'KK,': [1589], 'Endocrinol': [1606], 'Metab': [1607], '288:': [1608, 1648], 'E321–E326,': [1609], '2005.Link': [1610, 1650], 'Scholar10': [1615], 'LB,': [1623], 'Role': [1629], 'proinflammatory': [1635], 'proapoptotic': [1637], 'ischemia-reperfusion.': [1641], 'Circ': [1646], 'H221–H226,': [1649], 'Scholar11': [1655], 'Wichmann': [1656, 1699, 1740], 'Inthorn': [1658], 'D,': [1659], 'Andress': [1660], 'HJ,': [1661], 'Schildberg': [1663], 'FW.': [1664], 'Incidence': [1665], 'surgical': [1672], 'patients:': [1675], 'influence': [1677], 'patient': [1679], 'process': [1683], 'outcome.': [1685], 'Intensive': [1686], 'Care': [1687, 1766, 2126], 'Med': [1688, 1767], '26:': [1689], '167–172,': [1690], '2000.Crossref': [1691], 'Scholar12': [1698], 'Zellweger': [1701, 1738], 'R,': [1702, 1739], 'DeMaso': [1703, 1746], 'CM,': [1704, 1747], 'Enhanced': [1710], 'responses': [1712, 1719], 'females,': [1714], 'opposed': [1716], 'decreased': [1718], 'haemorrhagic': [1723], 'resuscitation.': [1726], 'Cytokine': [1727], '8:': [1728], '853–863,': [1729], '1996.Crossref': [1730], 'Scholar13': [1737], 'Stein': [1744], 'S,': [1745], 'Females': [1751], 'proestrus': [1753], 'state': [1754], 'maintain': [1755], 'splenic': [1756, 2087, 2368], 'functions': [1758, 2332], 'tolerate': [1760], 'males.': [1764], 'Crit': [1765], '25:': [1768], '106–110,': [1769], '1997.Crossref': [1770], 'ScholarAUTHOR': [1777], 'NOTESAddress': [1778], 'reprint': [1780], 'requests': [1781], 'correspondence:': [1784], 'D.': [1785, 2219], 'Meldrum,': [1787, 2217], '545': [1788], 'Barnhill': [1789], 'Dr.,': [1790], 'Emerson': [1791], 'Hall': [1792], 'Rm.': [1793], '215,': [1794], 'Indianapolis,': [1795], 'IN': [1796, 1847], '46202': [1797], 'Download': [1798], 'Previous': [1800], 'Back': [1801], 'Top': [1803], 'Next': [1804], 'FiguresReferencesRelatedInformationCited': [1805], 'ByEstrogen': [1806], 'heartMolecular': [1810], 'Cellular': [1812, 2029, 2392], 'Endocrinology,': [1813], 'Vol.': [1814, 1837, 1853, 1876, 1890, 1934, 1948, 1963, 2010, 2031, 2074, 2116, 2128, 2175, 2238, 2284, 2325, 2359, 2374, 2396], '389,': [1815], 'No.': [1816, 1839, 1855, 1878, 1892, 1936, 1950, 1965, 2012, 2033, 2076, 2118, 2130, 2177, 2240, 2286, 2327, 2361, 2376, 2398], '1-2Age-related': [1817], 'ischemia–reperfusion': [1821], 'injury:': [1822], 'deficiency23': [1826], 'March': [1827, 2422, 2428], '2013': [1828], 'Pflügers': [1830], 'Archiv': [1831], '-': [1832], 'European': [1833], '465,': [1838], '5THE': [1840], 'ROLE': [1841], 'OF': [1842], 'ESTROGEN': [1843], 'RECEPTOR': [1845], 'AGONISTS': [1846], 'MAINTAINING': [1848], 'ORGAN': [1849], 'FUNCTION': [1850], 'AFTER': [1851], 'TRAUMA-HEMORRHAGEShock,': [1852], '31,': [1854], "3Estradiol's": [1856], 'Salutary': [1857], 'Effects': [1858], 'Keratinocytes': [1860], 'Following': [1861], 'Trauma-Hemorrhage': [1862], 'Are': [1863], 'Mediated': [1864], 'Receptor': [1867], '(ER)-α': [1868], 'ER-β1': [1870], 'November': [1871, 2351], '2008': [1872, 1928, 1944, 1959, 2000], 'Medicine,': [1875, 1947, 1962, 2127], '14,': [1877, 1949, 1964], '11-12PROESTRUS': [1879], 'FEMALE': [1880], 'RATS': [1881], 'ARE': [1882], 'MORE': [1883], 'RESISTANT': [1884], 'TO': [1885], 'RIGHT': [1886], 'VENTRICULAR': [1887], 'PRESSURE': [1888], 'OVERLOADShock,': [1889], '30,': [1891], '3Flutamide': [1893], 'via': [1899], 'attenuation': [1900], 'response,': [1904], 'oxidative': [1905], 'stress,': [1906], 'apopotosisWen-Hong': [1908], 'Kan,': [1909, 2148], 'Chi-Hsun': [1910], 'Hsieh,': [1911, 2097, 2145, 2307], 'Martin': [1912, 2155, 2311, 2341], 'G.': [1913, 2156, 2312, 2342], 'Schwacha,': [1914, 2157, 2313, 2343], 'Mashkoor': [1915, 2098, 2152, 2264, 2308, 2338], 'A.': [1916, 1984, 2050, 2099, 2153, 2203, 2265, 2309, 2339], 'Choudhry,': [1917, 2100, 2154, 2266, 2310, 2340], 'Raghavan': [1918], 'Raju,': [1919], 'Kirby': [1920, 2101, 2158, 2267, 2344], 'I.': [1921, 2102, 2159, 2268, 2345], 'Bland,': [1922, 2103, 2160, 2269, 2346], 'H.': [1925, 2106, 2163, 2272, 2316, 2349], 'Chaudry1': [1926, 2107, 2164, 2273, 2317, 2350], 'August': [1927], 'Applied': [1932, 2323], '105,': [1935], '2Sex': [1937], 'Steroids': [1938], 'Stem': [1940], 'Function5': [1942], 'May': [1943, 1999, 2385], '7-8Estrogen,': [1951], 'NFκB,': [1952], 'Heat': [1955], 'Response11': [1957], 'April': [1958, 2228], '7-8Deleterious': [1966], 'exogenous': [1971], 'mesenchymal': [1974], 'stem': [1975, 2043], 'VEGF': [1977, 2190], 'productionRinki': [1978], 'Ray,': [1979], 'Christine': [1980, 2057, 2210], 'M.': [1981, 2058, 2211], 'Herring,': [1982, 2059, 2212], 'Troy': [1983], 'Markel,': [1985, 2051, 2204], 'Paul': [1986, 2052, 2205], 'Crisostomo,': [1988, 2054, 2207], 'Meijing': [1989, 2055, 2208], 'Wang,': [1990, 2056, 2209], 'Brent': [1991], 'Weil,': [1992], 'Tim': [1993, 2213], 'Lahm,': [1994, 2214], 'Daniel': [1996, 2061, 2225], 'Meldrum1': [1998, 2063, 2227], 'Physiology-Regulatory,': [2005], '294,': [2011], '5Estrogen-mediated': [2013], 'activation': [2014], 'non-genomic': [2016], 'pathway': [2017, 2137], 'trauma-hemorrhage1': [2023], 'January': [2024, 2274, 2318], '2007': [2025, 2065, 2109, 2166, 2229, 2275, 2319], '214,': [2032], '3Activation': [2034], 'individual': [2036], 'tumor': [2037], 'differentially': [2041], 'affects': [2042], 'growth': [2045], 'productionTroy': [2049], 'October': [2064], 'Physiology-Gastrointestinal': [2070, 2234, 2280], 'Liver': [2072, 2236, 2282], '293,': [2075, 2117], '4Estrogen': [2077], 'receptor-α': [2078], 'predominantly': [2079], 'mediates': [2080], 'salutary': [2082], '17β-estradiol': [2085, 2364], 'trauma-hemorrhageTakao': [2090, 2300], 'Suzuki,': [2091, 2301], 'Tomoharu': [2092, 2302], 'Shimizu,': [2093, 2303], 'Huang-Ping': [2094, 2304], 'Yu,': [2095, 2305], 'Ya-Ching': [2096, 2144, 2306], 'September': [2108], 'Physiology-Cell': [2114, 2357], '3Metabolic': [2119], 'modulators': [2120], 'sepsis:': [2123], 'hormonesCritical': [2125], '35,': [2129], 'SupplRole': [2131], 'p38': [2133], 'mitogen-activated': [2134], 'kinase': [2136], 'estrogen-mediated': [2139], 'cardioprotection': [2140], 'trauma-hemorrhageJun-Te': [2142], 'Hsu,': [2143], 'Wen': [2146], 'Hong': [2147], 'Jian': [2149], 'Guo': [2150], 'Chen,': [2151], 'June': [2165], 'Physiology-Heart': [2171], 'Circulatory': [2173], '292,': [2176, 2239, 2285], '6Iron': [2178], 'chelation': [2179], 'acutely': [2180], 'stimulates': [2181], 'fetal': [2182], 'intestinal': [2184], 'IL-6': [2188], 'decreasing': [2192], 'HGF:': [2193], 'roles': [2195], 'p38,': [2197], 'ERK,': [2198], 'JNK': [2200], 'signalingTroy': [2202], 'Kirstan': [2215], 'K.': [2216], 'Keith': [2218], 'Lillemoe,': [2220], 'Frederick': [2221], 'J.': [2222], 'Rescorla,': [2223], '4Liver': [2241], 'ICAM-1': [2245], 'expression': [2246], 'bone': [2248], 'fracture,': [2249], 'tissue': [2250], 'hemorrhage': [2253], 'middle-aged': [2255], 'miceTakeshi': [2256], 'Matsutani,': [2257], 'Shih-Ching': [2258], 'Kang,': [2259], 'Masao': [2260], 'Miyashita,': [2261], 'Koji': [2262], 'Sasajima,': [2263], '1Tissue': [2287], 'compartment-specific': [2288], 'subtypes': [2293], '102,': [2326], '1Lidocaine': [2328], 'depresses': [2329], 'miceTakashi': [2336], 'Kawasaki,': [2337], '2006': [2352, 2386, 2414, 2423, 2429], '291,': [2360], '5Effects': [2362], 'flutamide': [2366], 'splenocytes': [2371], 'trauma-hemorrhageCytokine,': [2373], '36,': [2375], '3-4Endocytosis': [2377], 'endothelium:': [2380], 'how': [2381], 'many?Radu': [2382], 'V.': [2383], 'Stan1': [2384], 'Physiology-Lung': [2391], '290,': [2397], '5': [2399], 'More': [2400], '>': [2404], 'Volume': [2405], '290Issue': [2406], '3March': [2407], '2006Pages': [2408], 'R809-R811': [2409], 'Copyright': [2410], '&': [2411], 'PermissionsCopyright': [2412], '©': [2413], 'Physiological': [2417], 'Societyhttps://doi.org/10.1152/ajpregu.00802.2005PubMed16467507History': [2418], 'Published': [2419, 2424], 'online': [2420], '1': [2421, 2427], 'print': [2426], 'Metrics': 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