Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2129664272', 'doi': 'https://doi.org/10.1093/toxsci/kfu216', 'title': 'Schisandrol B Protects Against Acetaminophen-Induced Hepatotoxicity by Inhibition of CYP-Mediated Bioactivation and Regulation of Liver Regeneration', 'display_name': 'Schisandrol B Protects Against Acetaminophen-Induced Hepatotoxicity by Inhibition of CYP-Mediated Bioactivation and Regulation of Liver Regeneration', 'publication_year': 2014, 'publication_date': '2014-10-14', 'ids': {'openalex': 'https://openalex.org/W2129664272', 'doi': 'https://doi.org/10.1093/toxsci/kfu216', 'mag': '2129664272', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25319358', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4334815'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/toxsci/kfu216', 'pdf_url': 'https://academic.oup.com/toxsci/article-pdf/143/1/107/10914659/kfu216.pdf', 'source': {'id': 'https://openalex.org/S186282544', 'display_name': 'Toxicological Sciences', 'issn_l': '1096-0929', 'issn': ['1096-0929', '1096-6080'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/toxsci/article-pdf/143/1/107/10914659/kfu216.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5088331911', 'display_name': 'Yiming Jiang', 'orcid': 'https://orcid.org/0000-0002-4894-177X'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yiming Jiang', 'raw_affiliation_strings': ['*School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.'], 'affiliations': [{'raw_affiliation_string': '*School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.', 'institution_ids': ['https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101845883', 'display_name': 'Xiaomei Fan', 'orcid': 'https://orcid.org/0000-0001-8251-7035'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaomei Fan', 'raw_affiliation_strings': ['*School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.'], 'affiliations': [{'raw_affiliation_string': '*School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.', 'institution_ids': ['https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100347261', 'display_name': 'Ying Wang', 'orcid': 'https://orcid.org/0000-0003-4524-1812'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ying Wang', 'raw_affiliation_strings': ['*School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.'], 'affiliations': [{'raw_affiliation_string': '*School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.', 'institution_ids': ['https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100435226', 'display_name': 'Pan Chen', 'orcid': 'https://orcid.org/0000-0003-0271-2725'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Pan Chen', 'raw_affiliation_strings': ['*School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.'], 'affiliations': [{'raw_affiliation_string': '*School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.', 'institution_ids': ['https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089397604', 'display_name': 'Hang Zeng', 'orcid': 'https://orcid.org/0000-0002-3140-0125'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hang Zeng', 'raw_affiliation_strings': ['*School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.'], 'affiliations': [{'raw_affiliation_string': '*School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.', 'institution_ids': ['https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080213407', 'display_name': 'Huasen Tan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Huasen Tan', 'raw_affiliation_strings': ['*School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.'], 'affiliations': [{'raw_affiliation_string': '*School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.', 'institution_ids': ['https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073932699', 'display_name': 'Frank J. Gonzalez', 'orcid': 'https://orcid.org/0000-0002-7990-2140'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Frank J. Gonzalez', 'raw_affiliation_strings': ['*School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.'], 'affiliations': [{'raw_affiliation_string': '*School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.', 'institution_ids': ['https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100655503', 'display_name': 'Min Huang', 'orcid': 'https://orcid.org/0000-0002-2844-5680'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Min Huang', 'raw_affiliation_strings': ['*School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.'], 'affiliations': [{'raw_affiliation_string': '*School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.', 'institution_ids': ['https://openalex.org/I157773358']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5020183416', 'display_name': 'Huichang Bi', 'orcid': 'https://orcid.org/0000-0001-7094-2296'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Huichang Bi', 'raw_affiliation_strings': ['*School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.'], 'affiliations': [{'raw_affiliation_string': '*School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.', 'institution_ids': ['https://openalex.org/I157773358']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4278, 'currency': 'USD', 'value_usd': 4278, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.881, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 66, 'citation_normalized_percentile': {'value': 0.881649, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '143', 'issue': '1', 'first_page': '107', 'last_page': '115'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12360', 'display_name': 'Biosynthesis and Pharmacological Activities of Lignans', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12360', 'display_name': 'Biosynthesis and Pharmacological Activities of Lignans', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11465', 'display_name': 'Mechanisms of Drug-Induced Hepatotoxicity', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11332', 'display_name': 'Role of Nrf2 Signaling in Oxidative Stress Response', 'score': 0.9939, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/acetaminophen', 'display_name': 'Acetaminophen', 'score': 0.6823646}, {'id': 'https://openalex.org/keywords/liver-regeneration', 'display_name': 'Liver regeneration', 'score': 0.65468496}, {'id': 'https://openalex.org/keywords/hepatotoxicity', 'display_name': 'Hepatotoxicity', 'score': 0.486123}], 'concepts': [{'id': 'https://openalex.org/C2778722691', 'wikidata': 'https://www.wikidata.org/wiki/Q57055', 'display_name': 'Acetaminophen', 'level': 2, 'score': 0.6823646}, {'id': 'https://openalex.org/C2776795407', 'wikidata': 'https://www.wikidata.org/wiki/Q19597761', 'display_name': 'Liver regeneration', 'level': 3, 'score': 0.65468496}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.61093706}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.5575971}, {'id': 'https://openalex.org/C171056886', 'wikidata': 'https://www.wikidata.org/wiki/Q193119', 'display_name': 'Regeneration (biology)', 'level': 2, 'score': 0.5426354}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.3555839}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.29531527}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.22608086}], 'mesh': [{'descriptor_ui': 'D000082', 'descriptor_name': 'Acetaminophen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D056486', 'descriptor_name': 'Chemical and Drug Induced Liver Injury', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': True}, {'descriptor_ui': 'D034242', 'descriptor_name': 'Cyclooctanes', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D019392', 'descriptor_name': 'Cytochrome P-450 CYP2E1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D065691', 'descriptor_name': 'Cytochrome P-450 CYP2E1 Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D065692', 'descriptor_name': 'Cytochrome P-450 CYP3A Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D004149', 'descriptor_name': 'Dioxoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D004365', 'descriptor_name': 'Drugs, Chinese Herbal', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D017705', 'descriptor_name': 'Lignans', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D008115', 'descriptor_name': 'Liver Regeneration', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D000082', 'descriptor_name': 'Acetaminophen', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D065767', 'descriptor_name': 'Activation, Metabolic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051017', 'descriptor_name': 'Apoptosis Regulatory Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051017', 'descriptor_name': 'Apoptosis Regulatory Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016227', 'descriptor_name': 'Benzoquinones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016227', 'descriptor_name': 'Benzoquinones', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020134', 'descriptor_name': 'Catalytic Domain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056486', 'descriptor_name': 'Chemical and Drug Induced Liver Injury', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056486', 'descriptor_name': 'Chemical and Drug Induced Liver Injury', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D056486', 'descriptor_name': 'Chemical and Drug Induced Liver Injury', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D034242', 'descriptor_name': 'Cyclooctanes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034242', 'descriptor_name': 'Cyclooctanes', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D019392', 'descriptor_name': 'Cytochrome P-450 CYP2E1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019392', 'descriptor_name': 'Cytochrome P-450 CYP2E1', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D065691', 'descriptor_name': 'Cytochrome P-450 CYP2E1 Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051544', 'descriptor_name': 'Cytochrome P-450 CYP3A', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D051544', 'descriptor_name': 'Cytochrome P-450 CYP3A', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051544', 'descriptor_name': 'Cytochrome P-450 CYP3A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D065692', 'descriptor_name': 'Cytochrome P-450 CYP3A Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019610', 'descriptor_name': 'Cytoprotection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004149', 'descriptor_name': 'Dioxoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004149', 'descriptor_name': 'Dioxoles', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004365', 'descriptor_name': 'Drugs, Chinese Herbal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005978', 'descriptor_name': 'Glutathione', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005978', 'descriptor_name': 'Glutathione', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007097', 'descriptor_name': 'Imines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007097', 'descriptor_name': 'Imines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017705', 'descriptor_name': 'Lignans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017705', 'descriptor_name': 'Lignans', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008115', 'descriptor_name': 'Liver Regeneration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008930', 'descriptor_name': 'Mitochondria, Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008930', 'descriptor_name': 'Mitochondria, Liver', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008930', 'descriptor_name': 'Mitochondria, Liver', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D062105', 'descriptor_name': 'Molecular Docking Simulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011487', 'descriptor_name': 'Protein Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/toxsci/kfu216', 'pdf_url': 'https://academic.oup.com/toxsci/article-pdf/143/1/107/10914659/kfu216.pdf', 'source': {'id': 'https://openalex.org/S186282544', 'display_name': 'Toxicological Sciences', 'issn_l': '1096-0929', 'issn': ['1096-0929', '1096-6080'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4334815', 'pdf_url': 'https://europepmc.org/articles/pmc4334815?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334815', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25319358', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/toxsci/kfu216', 'pdf_url': 'https://academic.oup.com/toxsci/article-pdf/143/1/107/10914659/kfu216.pdf', 'source': {'id': 'https://openalex.org/S186282544', 'display_name': 'Toxicological Sciences', 'issn_l': '1096-0929', 'issn': ['1096-0929', '1096-6080'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.84}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 38, 'referenced_works': ['https://openalex.org/W1650797637', 'https://openalex.org/W1973441276', 'https://openalex.org/W1976574909', 'https://openalex.org/W1978244308', 'https://openalex.org/W1980422482', 'https://openalex.org/W1981433577', 'https://openalex.org/W1983168442', 'https://openalex.org/W1984187829', 'https://openalex.org/W1988290861', 'https://openalex.org/W2007467111', 'https://openalex.org/W2010723255', 'https://openalex.org/W2018172663', 'https://openalex.org/W2023026888', 'https://openalex.org/W2023465339', 'https://openalex.org/W2032019687', 'https://openalex.org/W2035160058', 'https://openalex.org/W2043602177', 'https://openalex.org/W2055678464', 'https://openalex.org/W2056565128', 'https://openalex.org/W2067816697', 'https://openalex.org/W2068513519', 'https://openalex.org/W2072375091', 'https://openalex.org/W2075870842', 'https://openalex.org/W2082885785', 'https://openalex.org/W2085717234', 'https://openalex.org/W2086714780', 'https://openalex.org/W2094129884', 'https://openalex.org/W2097972249', 'https://openalex.org/W2100338188', 'https://openalex.org/W2113685352', 'https://openalex.org/W2138024058', 'https://openalex.org/W2141596938', 'https://openalex.org/W2147472643', 'https://openalex.org/W2155864743', 'https://openalex.org/W2157176268', 'https://openalex.org/W2168610924', 'https://openalex.org/W2405465455', 'https://openalex.org/W4240962591'], 'related_works': ['https://openalex.org/W4378082841', 'https://openalex.org/W4205869528', 'https://openalex.org/W3048499400', 'https://openalex.org/W2994882771', 'https://openalex.org/W2410136672', 'https://openalex.org/W2379672754', 'https://openalex.org/W2377953156', 'https://openalex.org/W2350451785', 'https://openalex.org/W2254999087', 'https://openalex.org/W1615990806'], 'abstract_inverted_index': {'Acetaminophen': [0], '(APAP)': [1], 'overdose': [2], 'is': [3, 15, 25], 'the': [4, 35, 47, 71, 87, 106, 119, 122, 140, 197], 'most': [5], 'frequent': [6], 'cause': [7], 'of': [8, 27, 38, 61, 89, 108, 118, 121, 152, 159, 190, 196], 'drug-induced': [9], 'acute': [10, 42], 'liver': [11, 65, 160, 185, 206], 'failure.': [12], 'Schisandra': [13], 'sphenanthera': [14], 'a': [16, 58, 94, 179], 'traditional': [17], 'hepato-protective': [18], 'Chinese': [19], 'medicine': [20], 'and': [21, 46, 53, 76, 80, 86, 110, 142, 154, 156, 162, 171, 194, 202], 'Schisandrol': [22], 'B': [23], '(SolB)': [24], 'one': [26], 'its': [28], 'major': [29], 'active': [30, 144], 'constituents.': [31], 'In': [32, 146], 'this': [33], 'study,': [34], 'protective': [36, 59, 181], 'effect': [37, 60, 182], 'SolB': [39, 62, 67, 97, 134, 148, 177], 'against': [40, 63], 'APAP-induced': [41, 64, 150, 184], 'hepatotoxicity': [43], 'in': [44, 73, 93], 'mice': [45], 'involved': [48], 'mechanisms': [49], 'were': [50], 'investigated.': [51], 'Morphological': [52], 'biochemical': [54], 'assessments': [55], 'clearly': [56], 'demonstrated': [57, 175], 'injury.': [66], 'pretreatment': [68], 'significantly': [69], 'attenuated': [70], 'increases': [72], 'alanine': [74], 'aminotransferase': [75, 78], 'aspartate': [77], 'activity,': [79], 'prevented': [81], 'elevated': [82], 'hepatic': [83], 'malondialdehyde': [84], 'formation': [85, 120], 'depletion': [88], 'mitochondrial': [90], 'glutathione': [91], '(GSH)': [92], 'dose-dependent': [95], 'manner.': [96], 'also': [98, 131], 'dramatically': [99], 'altered': [100], 'APAP': [101, 124, 192], 'metabolic': [102], 'activation': [103, 151], 'by': [104, 115], 'inhibiting': [105], 'activities': [107], 'CYP2E1': [109, 141], 'CYP3A11,': [111], 'which': [112], 'was': [113], 'evidenced': [114], 'significant': [116, 180], 'inhibition': [117, 189], 'oxidized': [123], 'metabolite': [125], 'NAPQI–GSH.': [126], 'A': [127], 'molecular': [128], 'docking': [129], 'model': [130], 'predicted': [132], 'that': [133, 176], 'had': [135], 'potential': [136], 'to': [137, 204], 'interact': [138], 'with': [139], 'CYP3A4': [143], 'sites.': [145], 'addition,': [147], 'abrogated': [149], 'p53': [153], 'p21,': [155, 199], 'increased': [157], 'expression': [158], 'regeneration': [161], 'antiapoptotic-related': [163], 'proteins': [164], 'such': [165], 'as': [166], 'cyclin': [167], 'D1': [168], '(CCND1),': [169], 'PCNA,': [170, 201], 'BCL-2.': [172], 'This': [173], 'study': [174], 'exhibited': [178], 'toward': [183], 'injury,': [186], 'potentially': [187], 'through': [188], 'CYP-mediated': [191], 'bioactivation': [193], 'regulation': [195], 'p53,': [198], 'CCND1,': [200], 'BCL-2': [203], 'promote': [205], 'regeneration.': [207]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2129664272', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 10}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 3}], 'updated_date': '2024-08-15T09:59:42.195736', 'created_date': '2016-06-24'}