Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2129326213', 'doi': 'https://doi.org/10.1042/bsr20150032', 'title': 'FSD-C10: A more promising novel ROCK inhibitor than Fasudil for treatment of CNS autoimmunity', 'display_name': 'FSD-C10: A more promising novel ROCK inhibitor than Fasudil for treatment of CNS autoimmunity', 'publication_year': 2015, 'publication_date': '2015-07-30', 'ids': {'openalex': 'https://openalex.org/W2129326213', 'doi': 'https://doi.org/10.1042/bsr20150032', 'mag': '2129326213', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26223433', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4721545'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1042/bsr20150032', 'pdf_url': 'https://portlandpress.com/bioscirep/article-pdf/35/5/e00247/477439/bsr035e247.pdf', 'source': {'id': 'https://openalex.org/S124713461', 'display_name': 'Bioscience Reports', 'issn_l': '0144-8463', 'issn': ['0144-8463', '1573-4935'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://portlandpress.com/bioscirep/article-pdf/35/5/e00247/477439/bsr035e247.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5031922597', 'display_name': 'Yan-le Xin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I5422934', 'display_name': 'Shanxi Datong University', 'ror': 'https://ror.org/03s8xc553', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I5422934']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yan-Le Xin', 'raw_affiliation_strings': ['Institute of Brain Science, Department of Neurology, Medical School, Shanxi Datong University, Datong 037009, China.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Brain Science, Department of Neurology, Medical School, Shanxi Datong University, Datong 037009, China.', 'institution_ids': ['https://openalex.org/I5422934']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051850521', 'display_name': 'Junjie Yu', 'orcid': 'https://orcid.org/0000-0002-4434-7001'}, 'institutions': [{'id': 'https://openalex.org/I5422934', 'display_name': 'Shanxi Datong University', 'ror': 'https://ror.org/03s8xc553', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I5422934']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jie-Zhong Yu', 'raw_affiliation_strings': ['Institute of Brain Science, Department of Neurology, Medical School, Shanxi Datong University, Datong 037009, China.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Brain Science, Department of Neurology, Medical School, Shanxi Datong University, Datong 037009, China.', 'institution_ids': ['https://openalex.org/I5422934']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035543354', 'display_name': 'Xinwang Yang', 'orcid': 'https://orcid.org/0000-0003-3210-8908'}, 'institutions': [{'id': 'https://openalex.org/I5422934', 'display_name': 'Shanxi Datong University', 'ror': 'https://ror.org/03s8xc553', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I5422934']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xin-Wang Yang', 'raw_affiliation_strings': ['Institute of Brain Science, Department of Neurology, Medical School, Shanxi Datong University, Datong 037009, China.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Brain Science, Department of Neurology, Medical School, Shanxi Datong University, Datong 037009, China.', 'institution_ids': ['https://openalex.org/I5422934']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089462504', 'display_name': 'Chunyun Liu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I5422934', 'display_name': 'Shanxi Datong University', 'ror': 'https://ror.org/03s8xc553', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I5422934']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chun-Yun Liu', 'raw_affiliation_strings': ['Institute of Brain Science, Department of Neurology, Medical School, Shanxi Datong University, Datong 037009, China.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Brain Science, Department of Neurology, Medical School, Shanxi Datong University, Datong 037009, China.', 'institution_ids': ['https://openalex.org/I5422934']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100630055', 'display_name': 'Yanhua Li', 'orcid': 'https://orcid.org/0000-0001-5149-2023'}, 'institutions': [{'id': 'https://openalex.org/I5422934', 'display_name': 'Shanxi Datong University', 'ror': 'https://ror.org/03s8xc553', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I5422934']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yan-Hua Li', 'raw_affiliation_strings': ['Institute of Brain Science, Department of Neurology, Medical School, Shanxi Datong University, Datong 037009, China.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Brain Science, Department of Neurology, Medical School, Shanxi Datong University, Datong 037009, China.', 'institution_ids': ['https://openalex.org/I5422934']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100448827', 'display_name': 'Feng Ling', 'orcid': 'https://orcid.org/0000-0001-7580-807X'}, 'institutions': [{'id': 'https://openalex.org/I5422934', 'display_name': 'Shanxi Datong University', 'ror': 'https://ror.org/03s8xc553', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I5422934']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ling Feng', 'raw_affiliation_strings': ['Institute of Brain Science, Department of Neurology, Medical School, Shanxi Datong University, Datong 037009, China.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Brain Science, Department of Neurology, Medical School, Shanxi Datong University, Datong 037009, China.', 'institution_ids': ['https://openalex.org/I5422934']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101399250', 'display_name': 'Zhi Chai', 'orcid': 'https://orcid.org/0000-0002-4586-6807'}, 'institutions': [{'id': 'https://openalex.org/I181877577', 'display_name': 'Shanxi University', 'ror': 'https://ror.org/03y3e3s17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I181877577']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhi Chai', 'raw_affiliation_strings': ['“2011” Collaborative Innovation Center/Research Center of Neurobiology, Shanxi University of Traditional Chinese Medicine, Taiyuan 030619, China'], 'affiliations': [{'raw_affiliation_string': '“2011” Collaborative Innovation Center/Research Center of Neurobiology, Shanxi University of Traditional Chinese Medicine, Taiyuan 030619, China', 'institution_ids': ['https://openalex.org/I181877577']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081975222', 'display_name': 'Wanfang Yang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181877577', 'display_name': 'Shanxi University', 'ror': 'https://ror.org/03y3e3s17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I181877577']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wan-Fang Yang', 'raw_affiliation_strings': ['“2011” Collaborative Innovation Center/Research Center of Neurobiology, Shanxi University of Traditional Chinese Medicine, Taiyuan 030619, China'], 'affiliations': [{'raw_affiliation_string': '“2011” Collaborative Innovation Center/Research Center of Neurobiology, Shanxi University of Traditional Chinese Medicine, Taiyuan 030619, China', 'institution_ids': ['https://openalex.org/I181877577']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100434882', 'display_name': 'Qing Wang', 'orcid': 'https://orcid.org/0000-0003-1284-4705'}, 'institutions': [{'id': 'https://openalex.org/I181877577', 'display_name': 'Shanxi University', 'ror': 'https://ror.org/03y3e3s17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I181877577']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qing Wang', 'raw_affiliation_strings': ['“2011” Collaborative Innovation Center/Research Center of Neurobiology, Shanxi University of Traditional Chinese Medicine, Taiyuan 030619, China'], 'affiliations': [{'raw_affiliation_string': '“2011” Collaborative Innovation Center/Research Center of Neurobiology, Shanxi University of Traditional Chinese Medicine, Taiyuan 030619, China', 'institution_ids': ['https://openalex.org/I181877577']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5104031360', 'display_name': 'Weijia Jiang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181877577', 'display_name': 'Shanxi University', 'ror': 'https://ror.org/03y3e3s17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I181877577']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wei-Jia Jiang', 'raw_affiliation_strings': ['“2011” Collaborative Innovation Center/Research Center of Neurobiology, Shanxi University of Traditional Chinese Medicine, Taiyuan 030619, China'], 'affiliations': [{'raw_affiliation_string': '“2011” Collaborative Innovation Center/Research Center of Neurobiology, Shanxi University of Traditional Chinese Medicine, Taiyuan 030619, China', 'institution_ids': ['https://openalex.org/I181877577']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101457991', 'display_name': 'Guang‐Xian Zhang', 'orcid': 'https://orcid.org/0000-0003-0017-5997'}, 'institutions': [{'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Guang-Xian Zhang', 'raw_affiliation_strings': ['Department of Neurology, Thomas Jefferson University, Philadelphia, PA, 19107, U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Thomas Jefferson University, Philadelphia, PA, 19107, U.S.A.', 'institution_ids': ['https://openalex.org/I149251103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045137608', 'display_name': 'Bao‐Guo Xiao', 'orcid': 'https://orcid.org/0000-0003-3335-8992'}, 'institutions': [{'id': 'https://openalex.org/I4210159575', 'display_name': 'Huashan Hospital', 'ror': 'https://ror.org/05201qm87', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210159575']}, {'id': 'https://openalex.org/I24943067', 'display_name': 'Fudan University', 'ror': 'https://ror.org/013q1eq08', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24943067']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Bao-Guo Xiao', 'raw_affiliation_strings': ['Institute of Neurology, Huashan Hospital, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200040, China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Neurology, Huashan Hospital, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200040, China', 'institution_ids': ['https://openalex.org/I4210159575', 'https://openalex.org/I24943067']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103148576', 'display_name': 'Cun‐Gen Ma', 'orcid': 'https://orcid.org/0000-0003-0049-1658'}, 'institutions': [{'id': 'https://openalex.org/I5422934', 'display_name': 'Shanxi Datong University', 'ror': 'https://ror.org/03s8xc553', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I5422934']}, {'id': 'https://openalex.org/I181877577', 'display_name': 'Shanxi University', 'ror': 'https://ror.org/03y3e3s17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I181877577']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Cun-Gen Ma', 'raw_affiliation_strings': ['Institute of Brain Science, Department of Neurology, Medical School, Shanxi Datong University, Datong 037009, China', '“2011” Collaborative Innovation Center/Research Center of Neurobiology, Shanxi University of Traditional Chinese Medicine, Taiyuan 030619, China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Brain Science, Department of Neurology, Medical School, Shanxi Datong University, Datong 037009, China', 'institution_ids': ['https://openalex.org/I5422934']}, {'raw_affiliation_string': '“2011” Collaborative Innovation Center/Research Center of Neurobiology, Shanxi University of Traditional Chinese Medicine, Taiyuan 030619, China', 'institution_ids': ['https://openalex.org/I181877577']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 1960, 'currency': 'USD', 'value_usd': 1960, 'provenance': 'doaj'}, 'apc_paid': {'value': 1960, 'currency': 'USD', 'value_usd': 1960, 'provenance': 'doaj'}, 'fwci': 1.498, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 29, 'citation_normalized_percentile': {'value': 0.999857, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '35', 'issue': '5', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10483', 'display_name': 'Roles of Neurotrophins in Nervous System Function', 'score': 0.9931, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10483', 'display_name': 'Roles of Neurotrophins in Nervous System Function', 'score': 0.9931, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10608', 'display_name': 'Adult Neurogenesis and Brain Development', 'score': 0.9868, 'subfield': {'id': 'https://openalex.org/subfields/2806', 'display_name': 'Developmental Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12061', 'display_name': 'Molecular Mechanisms of Axon Guidance', 'score': 0.9839, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/fasudil', 'display_name': 'Fasudil', 'score': 0.97349125}, {'id': 'https://openalex.org/keywords/neurite', 'display_name': 'Neurite', 'score': 0.74839467}, {'id': 'https://openalex.org/keywords/rho-kinase-inhibitor', 'display_name': 'Rho kinase inhibitor', 'score': 0.47835013}, {'id': 'https://openalex.org/keywords/neuronal-plasticity', 'display_name': 'Neuronal Plasticity', 'score': 0.432627}], 'concepts': [{'id': 'https://openalex.org/C2776048814', 'wikidata': 'https://www.wikidata.org/wiki/Q5437132', 'display_name': 'Fasudil', 'level': 4, 'score': 0.97349125}, {'id': 'https://openalex.org/C113246987', 'wikidata': 'https://www.wikidata.org/wiki/Q1534415', 'display_name': 'Neurite', 'level': 3, 'score': 0.74839467}, {'id': 'https://openalex.org/C201800478', 'wikidata': 'https://www.wikidata.org/wiki/Q24721770', 'display_name': 'Rho-associated protein kinase', 'level': 3, 'score': 0.6717034}, {'id': 'https://openalex.org/C160539049', 'wikidata': 'https://www.wikidata.org/wiki/Q3064187', 'display_name': 'Neurotrophic factors', 'level': 3, 'score': 0.62775934}, {'id': 'https://openalex.org/C2778609687', 'wikidata': 'https://www.wikidata.org/wiki/Q18390224', 'display_name': 'Rho kinase inhibitor', 'level': 4, 'score': 0.47835013}, {'id': 'https://openalex.org/C92020748', 'wikidata': 'https://www.wikidata.org/wiki/Q420457', 'display_name': 'Neurotrophin', 'level': 3, 'score': 0.45636553}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.45596805}, {'id': 'https://openalex.org/C2778790584', 'wikidata': 'https://www.wikidata.org/wiki/Q123045', 'display_name': 'Brain-derived neurotrophic factor', 'level': 4, 'score': 0.43506148}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.36363167}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.30918726}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2886396}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.21730426}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.14926672}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D019307', 'descriptor_name': '1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D004679', 'descriptor_name': 'Encephalomyelitis', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D054460', 'descriptor_name': 'rho-Associated Kinases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015551', 'descriptor_name': 'Autoimmunity', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007546', 'descriptor_name': 'Isoquinolines', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018696', 'descriptor_name': 'Neuroprotective Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014664', 'descriptor_name': 'Vasodilation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1042/bsr20150032', 'pdf_url': 'https://portlandpress.com/bioscirep/article-pdf/35/5/e00247/477439/bsr035e247.pdf', 'source': {'id': 'https://openalex.org/S124713461', 'display_name': 'Bioscience Reports', 'issn_l': '0144-8463', 'issn': ['0144-8463', '1573-4935'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4721545', 'pdf_url': 'https://europepmc.org/articles/pmc4721545?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://jdc.jefferson.edu/neurologyfp/86', 'pdf_url': 'https://jdc.jefferson.edu/cgi/viewcontent.cgi?article=1085&context=neurologyfp', 'source': {'id': 'https://openalex.org/S4306401450', 'display_name': 'Jefferson Digital Commons (Thomas Jefferson University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I149251103', 'host_organization_name': 'Thomas Jefferson University', 'host_organization_lineage': ['https://openalex.org/I149251103'], 'host_organization_lineage_names': ['Thomas Jefferson University'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721545', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26223433', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1042/bsr20150032', 'pdf_url': 'https://portlandpress.com/bioscirep/article-pdf/35/5/e00247/477439/bsr035e247.pdf', 'source': {'id': 'https://openalex.org/S124713461', 'display_name': 'Bioscience Reports', 'issn_l': '0144-8463', 'issn': ['0144-8463', '1573-4935'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.7}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 51, 'referenced_works': ['https://openalex.org/W1498274359', 'https://openalex.org/W1514296939', 'https://openalex.org/W1900649416', 'https://openalex.org/W1967847339', 'https://openalex.org/W1979722180', 'https://openalex.org/W1983074248', 'https://openalex.org/W1983443986', 'https://openalex.org/W1988768639', 'https://openalex.org/W1990021026', 'https://openalex.org/W1990786323', 'https://openalex.org/W1992287871', 'https://openalex.org/W1994986028', 'https://openalex.org/W2000737077', 'https://openalex.org/W2011497398', 'https://openalex.org/W2012423618', 'https://openalex.org/W2013940038', 'https://openalex.org/W2017315346', 'https://openalex.org/W2018644247', 'https://openalex.org/W2019619408', 'https://openalex.org/W2025259420', 'https://openalex.org/W2031164346', 'https://openalex.org/W2034341467', 'https://openalex.org/W2036625562', 'https://openalex.org/W2038122755', 'https://openalex.org/W2043059291', 'https://openalex.org/W2053523260', 'https://openalex.org/W2058360762', 'https://openalex.org/W2059442573', 'https://openalex.org/W2063593499', 'https://openalex.org/W2074698464', 'https://openalex.org/W2078616546', 'https://openalex.org/W2078889714', 'https://openalex.org/W2079169807', 'https://openalex.org/W2081422555', 'https://openalex.org/W2084292803', 'https://openalex.org/W2084722299', 'https://openalex.org/W2092683047', 'https://openalex.org/W2094589299', 'https://openalex.org/W2101072720', 'https://openalex.org/W2102622163', 'https://openalex.org/W2116521234', 'https://openalex.org/W2124212015', 'https://openalex.org/W2127447774', 'https://openalex.org/W2127685830', 'https://openalex.org/W2130395505', 'https://openalex.org/W2154894697', 'https://openalex.org/W2159516737', 'https://openalex.org/W2159692236', 'https://openalex.org/W2161467739', 'https://openalex.org/W2468628232', 'https://openalex.org/W4236841553'], 'related_works': ['https://openalex.org/W3147902037', 'https://openalex.org/W2901254158', 'https://openalex.org/W2887634394', 'https://openalex.org/W2801533599', 'https://openalex.org/W2357886252', 'https://openalex.org/W2111612845', 'https://openalex.org/W2064674730', 'https://openalex.org/W2043520273', 'https://openalex.org/W2020985989', 'https://openalex.org/W1750949018'], 'abstract_inverted_index': {'Rho-Rho': [0], 'kinase': [1], '(Rho-ROCK)': [2], 'triggers': [3], 'an': [4], 'intracellular': [5], 'signalling': [6], 'cascade': [7], 'that': [8, 108], 'regulates': [9], 'cell': [10, 90, 135, 145], 'survival,': [11], 'death,': [12], 'adhesion,': [13], 'migration,': [14], 'neurite': [15, 92, 113], 'outgrowth': [16, 93, 114], 'and': [17, 19, 23, 48, 64, 76, 86, 94, 99, 103, 117, 123, 140, 147, 163, 183, 192], 'retraction': [18], 'influences': [20], 'the': [21, 57, 71, 81, 89, 125, 144, 201], 'generation': [22], 'development': [24], 'of': [25, 66, 84, 115, 120, 127, 149, 203], 'several': [26, 204], 'neurological': [27, 205], 'disorders.': [28, 206], 'Although': [29, 157], 'Fasudil,': [30, 111], 'a': [31, 190], 'ROCK': [32, 50, 77, 87, 161, 164, 170, 174, 196], 'inhibitor,': [33, 51], 'effectively': [34], 'suppressed': [35, 169], 'encephalomyelitis': [36], '(EAE),': [37], 'certain': [38], 'side': [39], 'effects': [40], 'may': [41, 177, 188], 'limit': [42], 'its': [43], 'clinical': [44], 'use.': [45], 'A': [46], 'novel': [47, 195], 'efficient': [49], 'FSD-C10,': [52, 67, 109], 'has': [53], 'been': [54], 'explored.': [55], 'In': [56], 'present': [58, 61], 'study,': [59], 'we': [60], 'chemical': [62], 'synthesis': [63], 'structure': [65], 'as': [68, 70], 'well': [69], 'relationship': [72], 'between': [73, 101], 'compound': [74], 'concentration': [75], 'inhibition.': [78], 'We': [79], 'compared': [80, 154], 'inhibitory': [82], 'efficiency': [83], 'ROCKI': [85], 'II,': [88, 165, 171], 'cytotoxicity,': [91], 'dendritic': [95, 118], 'formation,': [96], 'neurotrophic': [97, 128, 131, 137], 'factors': [98], 'vasodilation': [100, 148, 181], 'Fasudil': [102, 158, 199], 'FSD-C10.': [104], 'The': [105], 'results': [106], 'demonstrated': [107], 'like': [110], 'induced': [112], 'neurons': [116], 'formation': [119], 'BV-2': [121], 'microglia': [122], 'enhanced': [124], 'production': [126], 'factor': [129, 132, 138], 'brain-derived': [130], '(BDNF),': [133], 'glial': [134], 'line-derived': [136], '(GDNF)': [139], 'neurotrophin-3': [141], '(NT-3).': [142], 'However,': [143], 'cytotoxicity': [146], 'FSD-C10': [150, 166, 187], 'were': [151], 'relatively': [152], 'small': [153], 'with': [155], 'Fasudil.': [156], 'inhibited': [159], 'both': [160], 'I': [162], 'more': [167, 193], 'selectively': [168], 'but': [172], 'not': [173], 'I,': [175], 'which': [176], 'be': [178, 189], 'related': [179], 'to': [180], 'insensitivity': [182], 'animal': [184], 'mortality.': [185], 'Thus,': [186], 'safer': [191], 'promising': [194], 'inhibitor': [197], 'than': [198], 'for': [200], 'treatment': [202]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2129326213', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-09-19T18:33:03.266169', 'created_date': '2016-06-24'}