Title: Selective inhibition of human glial inducible nitric oxide synthase by interferon‐β: Implications for multiple sclerosis
Abstract: Abstract Nitric oxide generated from the inducible nitric oxide synthase (iNOS) has been implicated in the pathogenesis of multiple sclerosis. Because significant species‐ and cell‐specific differences exist in the expression of iNOS, we used primary human glial cell cultures to screen for an inhibitor of iNOS expression. Remarkably, among numerous soluble factors tested, interferon‐β (IFN‐β) alone showed a selective and potent inhibition of interleukin‐1β/interferon‐γ (IL‐1β/IFN‐)–induced iNOS expression in astrocytes. Inhibition of iNOS may provide a mechanism by which IFN‐β can ameliorate inflammation and cytotoxicity in the central nervous system of patients with multiple sclerosis.
Publication Year: 1998
Publication Date: 1998-03-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 74
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