Inhibitor of DNA Binding/Differentiation Helix-Loop-Helix Proteins Mediate Bone Morphogenetic Protein-induced Osteoblast Differentiation of Mesenchymal Stem Cells

Name: Work Video:
Duration: 3 min 30 s
Ying Peng; Quan Kang; Qing Luo; Wei Jiang; Weike Si; Bernard A. Liu; Hue H. Luu; Jong Kyung Park; Xinmin Li; Jeffrey Luo; Anthony Montag; Rex C. Haydon; Tong‐Chuan He
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None, 'is_major_topic': False}, {'descriptor_ui': 'D015534', 'descriptor_name': 'Trans-Activators', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m403344200', 'pdf_url': 'http://www.jbc.org/article/S0021925820775952/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15161906', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m403344200', 'pdf_url': 'http://www.jbc.org/article/S0021925820775952/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of 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'https://openalex.org/W2157795344', 'https://openalex.org/W2158707966', 'https://openalex.org/W2166920557', 'https://openalex.org/W2170115375', 'https://openalex.org/W2170602248', 'https://openalex.org/W2172326429', 'https://openalex.org/W4239370680', 'https://openalex.org/W4253422011', 'https://openalex.org/W4294107304', 'https://openalex.org/W56968267'], 'related_works': ['https://openalex.org/W4242486335', 'https://openalex.org/W4240822643', 'https://openalex.org/W4230801422', 'https://openalex.org/W3101550007', 'https://openalex.org/W2919616119', 'https://openalex.org/W2752589608', 'https://openalex.org/W2606517225', 'https://openalex.org/W2495905015', 'https://openalex.org/W2165658291', 'https://openalex.org/W2091413202'], 'abstract_inverted_index': {'Bone': [0, 232, 464, 530, 916, 1167, 1738, 1833, 2706, 2908, 3810], 'morphogenetic': [1, 233, 531, 540], 'proteins': [2, 78, 183, 234, 310, 415, 532, 1193, 1265, 1293, 1310, 1388, 1479, 2440, 2503, 2601, 3635, 3659, 3835, 4346], '(BMPs)': [3, 235, 533], 'belong': [4, 236, 633], 'to': [5, 70, 106, 162, 223, 237, 302, 338, 394, 455, 522, 634, 862, 1199, 1220, 1272, 1279, 1304, 1306, 1381, 1439, 1520, 1982, 2097, 2144, 2333, 2350, 2365, 2393, 2443, 2792, 2867, 3035, 3187, 3199, 3416, 3534, 3601, 3627, 3675, 3845, 3902, 4463], 'the': [6, 30, 45, 56, 72, 86, 98, 122, 156, 180, 191, 206, 238, 262, 277, 288, 304, 318, 330, 354, 388, 412, 423, 438, 519, 635, 744, 787, 806, 851, 872, 964, 974, 979, 1028, 1187, 1191, 1275, 1281, 1299, 1312, 1319, 1383, 1418, 1421, 1452, 1468, 1487, 1535, 1771, 1774, 1778, 1801, 1963, 1983, 2146, 2151, 2160, 2179, 2281, 2300, 2310, 2326, 2335, 2378, 2383, 2394, 2400, 2413, 2417, 2472, 2508, 2564, 2586, 2610, 2626, 2752, 2787, 2813, 2816, 2835, 2864, 2954, 2962, 2992, 3025, 3030, 3046, 3121, 3131, 3139, 3174, 3292, 3297, 3305, 3311, 3324, 3363, 3366, 3419, 3445, 3456, 3506, 3510, 3516, 3529, 3565, 3570, 3591, 3594, 3608, 3629, 3632, 3645, 3652, 3830, 3850, 3883, 3908, 3948, 3951, 3959, 3966, 3999, 4009, 4029, 4035, 4079, 4093, 4108, 4118, 4147, 4168, 4175, 4179, 4237, 4264, 4284, 4292, 4309, 4334, 4343, 4352, 4363, 4368, 4377, 4397, 4404, 4453, 4471, 4487, 4502, 4515, 4517, 4521], 'TGF-β': [7, 239, 636, 1087], 'superfamily': [8, 240, 637], 'and': [9, 16, 27, 52, 91, 104, 198, 241, 248, 259, 284, 323, 336, 430, 526, 587, 638, 725, 756, 804, 864, 869, 886, 1024, 1041, 1088, 1270, 1327, 1334, 1399, 1404, 1424, 1437, 1494, 1526, 1528, 1540, 1579, 1609, 1640, 1672, 1695, 1785, 1789, 1868, 1929, 1951, 1988, 2017, 2039, 2079, 2116, 2130, 2154, 2216, 2228, 2242, 2428, 2469, 2478, 2532, 2559, 2575, 2669, 2749, 2801, 2829, 2845, 2861, 2878, 2978, 2980, 2986, 3045, 3112, 3127, 3184, 3280, 3329, 3337, 3348, 3369, 3450, 3462, 3471, 3504, 3551, 3577, 3583, 3657, 3669, 3687, 3695, 3722, 3889, 3914, 3935, 3946, 3958, 3979, 4015, 4044, 4078, 4091, 4139, 4153, 4159, 4198, 4206, 4322, 4403, 4491, 4496], 'play': [10, 185, 242, 417, 579, 639, 1481, 4347], 'an': [11, 170, 186, 243, 402, 418, 580, 640, 1431, 1482, 1881, 2444, 3244, 4348], 'important': [12, 187, 244, 419, 581, 641, 1483, 4349, 4382], 'role': [13, 74, 188, 245, 306, 420, 582, 642, 1189, 1385, 1484, 3832, 4350], 'in': [14, 17, 79, 189, 246, 249, 311, 421, 583, 643, 671, 722, 811, 884, 887, 1194, 1207, 1289, 1324, 1389, 1408, 1485, 1592, 1617, 1624, 1653, 1657, 1934, 1942, 2084, 2301, 2354, 2424, 2459, 2746, 2825, 2876, 2879, 2965, 3248, 3289, 3304, 3310, 3360, 3374, 3383, 3500, 3515, 3523, 3545, 3569, 3618, 3662, 3716, 3836, 3893, 3907, 3942, 4034, 4041, 4087, 4142, 4156, 4162, 4174, 4189, 4195, 4234, 4247, 4286, 4351], 'development': [15, 247, 644], 'many': [18, 250], 'cellular': [19, 251], 'processes.': [20, 252], 'We': [21, 83, 253, 315, 844, 1019, 1393, 1414, 3022, 3413, 3604, 3624, 3843, 3988, 4006, 4027, 4211, 4480], 'have': [22, 254, 668, 720, 845, 972, 2852, 3438, 3861], 'found': [23, 255, 865, 1020, 3023, 3439, 3606], 'that': [24, 44, 85, 148, 166, 179, 199, 213, 256, 276, 317, 380, 398, 411, 431, 445, 517, 866, 983, 1021, 1079, 1401, 1417, 1477, 1495, 1509, 2793, 3024, 3098, 3173, 3440, 3607, 3692, 3727, 3872, 3991, 4254, 4283, 4342, 4376, 4448, 4485], 'BMP-2,': [25, 62, 257, 294, 867, 1039, 2843, 2859, 2976, 3182, 3335], 'BMP-6,': [26, 63, 258, 295, 868, 1040, 2844, 2860, 2977, 3183, 3336], 'BMP-9': [28, 65, 102, 260, 297, 334, 870, 1042, 1435, 1694, 1701, 2862, 3185, 3338, 3435, 3441, 3563, 3637, 3702, 4327], 'induce': [29, 261, 2868], 'most': [31, 57, 263, 289, 873, 1029, 3134, 3446], 'potent': [32, 264, 874, 3447], 'osteogenic': [33, 124, 173, 265, 356, 405, 852, 877, 987, 1036, 1196, 1409, 1454, 2958, 2973, 3031, 3116, 3140, 3249, 3306, 3427, 3448, 3866, 4357, 4386, 4458, 4478], 'differentiation': [34, 125, 141, 208, 227, 266, 357, 373, 440, 459, 474, 586, 878, 1197, 1455, 1470, 1503, 2870], 'of': [35, 47, 75, 88, 101, 117, 126, 134, 155, 172, 193, 209, 217, 228, 267, 279, 307, 320, 333, 349, 358, 366, 387, 404, 425, 441, 449, 460, 471, 560, 666, 718, 747, 808, 850, 854, 857, 879, 978, 1035, 1086, 1190, 1260, 1283, 1341, 1386, 1420, 1434, 1448, 1456, 1463, 1489, 1504, 1513, 1582, 1607, 1612, 1638, 1643, 1670, 1675, 1773, 1781, 1925, 1958, 2020, 2092, 2141, 2150, 2159, 2225, 2284, 2289, 2305, 2316, 2328, 2382, 2399, 2501, 2563, 2599, 2663, 2770, 2783, 2786, 2794, 2841, 2849, 2871, 3029, 3042, 3078, 3120, 3205, 3318, 3323, 3365, 3444, 3455, 3488, 3509, 3528, 3555, 3593, 3610, 3631, 3647, 3654, 3701, 3712, 3833, 3856, 3886, 3937, 3968, 3998, 4050, 4095, 4146, 4216, 4239, 4250, 4266, 4295, 4301, 4311, 4355, 4367, 4384, 4396, 4409, 4452, 4470, 4501], 'mesenchymal': [36, 127, 229, 268, 359, 461, 493, 880, 1411, 1457, 2872, 3252], 'stem': [37, 230, 269, 462, 494, 881, 1412, 3253], 'cells.': [38, 129, 231, 270, 361, 463, 1413, 3525, 4037, 4336], 'Expression': [39, 271, 3715, 4361], 'profiling': [40, 272, 1397, 3246], 'analysis': [41, 273, 849, 1398, 2019, 2042, 2137, 2174, 3247, 3976, 4510], 'has': [42, 274, 3196], 'revealed': [43, 275, 3097], 'Inhibitors': [46, 278], 'DNA': [48, 280, 561, 1273, 1307, 1316, 1874, 2181], 'binding/differentiation': [49, 281], '(Id)-1,': [50, 282], 'Id-2,': [51, 90, 283, 322, 1023, 1403, 1423, 1784, 2153, 2340, 2477, 2574, 2828, 3126, 3368, 3582, 3656, 3694, 3888, 4100, 4152, 4490], 'Id-3': [53, 92, 285, 324, 1025, 1328, 1405, 1425, 1786, 2155, 2479, 2576, 2830, 3370, 3658, 3696, 3890, 4102, 4154, 4492], 'are': [54, 286, 871, 1026, 1074, 1302, 1329, 1920, 2402, 3697, 3730], 'among': [55, 287, 1027, 2834, 2856, 3130], 'significantly': [58, 95, 120, 290, 327, 352, 1030, 3135, 3332, 3615, 4039], 'up-regulated': [59, 291, 1031, 1407, 3111, 3136, 3373], 'genes': [60, 93, 137, 159, 292, 325, 369, 391, 810, 1032, 1081, 1203, 1285, 1322, 1426, 1465, 3102, 3137, 3177, 3300, 3371, 3422, 3491, 3513, 3532, 3559, 3597, 3729, 3891, 3970, 4222, 4379, 4400, 4455, 4473, 4504], 'upon': [61, 293, 1033, 1922, 2164, 2404, 3636], 'or': [64, 296, 508, 793, 1960, 1996, 2419, 2512, 2631, 3275, 3469, 3519, 3848, 3854, 4025, 4068, 4101, 4241, 4268, 4466], 'stimulation.': [66, 113, 298, 345, 1445], 'Here,': [67, 299, 4460], 'we': [68, 146, 300, 378, 971, 1379, 1879, 2298, 2960, 3241, 3432, 3437, 3877, 4446, 4461], 'sought': [69, 301, 1380, 3415, 3626, 3844, 4462], 'determine': [71, 303, 1382, 3628, 3846, 4464], 'functional': [73, 305, 1188, 1384], 'these': [76, 135, 308, 367, 4338], 'Id': [77, 118, 136, 150, 158, 181, 200, 218, 309, 350, 368, 382, 390, 413, 432, 450, 1080, 1192, 1202, 1292, 1309, 1321, 1387, 1449, 1464, 1478, 1496, 1514, 1775, 1795, 2290, 2502, 2600, 3122, 3176, 3299, 3421, 3490, 3512, 3531, 3558, 3596, 3634, 3713, 3728, 3834, 3857, 3875, 3953, 3969, 3986, 4000, 4221, 4257, 4271, 4302, 4345, 4360, 4378, 4399, 4454, 4472, 4503], 'BMP-induced': [80, 224, 312, 456, 968, 1195, 1390, 1521], 'osteoblast': [81, 140, 195, 225, 313, 372, 427, 457, 472, 585, 969, 1391, 1469, 1491, 2869], 'differentiation.': [82, 174, 314, 406, 1392, 3867, 4459, 4479], 'demonstrated': [84, 147, 316, 379, 1416, 2854, 3972], 'expression': [87, 119, 151, 201, 219, 319, 351, 383, 433, 451, 807, 976, 1342, 1396, 1419, 1450, 1497, 1516, 2282, 2963, 3027, 3104, 3245, 3364, 3486, 3508, 3527, 3554, 3592, 3609, 3859, 3955, 3967, 4394, 4451, 4500], 'Id-1,': [89, 321, 1022, 1402, 1422, 1783, 2152, 2339, 2827, 3125, 3367, 3581, 3655, 3693, 3887, 4099, 4151, 4489], 'was': [94, 160, 167, 326, 392, 399, 1427, 1706, 1970, 2005, 2110, 2175, 2192, 2263, 2331, 2348, 2386, 2504, 2602, 2645, 2823, 3033, 3282, 3372, 3474, 3492, 3560, 3613, 3922, 3993, 4082, 4113, 4129, 4201, 4260, 4505], 'induced': [96, 328, 1429, 3180, 3333, 3425, 3561], 'at': [97, 109, 329, 341, 1430, 1614, 1645, 1677, 2205, 2231, 2253, 2325, 2463, 2526, 2553, 2621, 2805, 3107, 3476, 3536, 3666], 'early': [99, 194, 331, 426, 1432, 1490, 3699, 4051, 4353], 'stage': [100, 332, 1433, 4354], 'stimulation': [103, 335, 1034, 1436, 3638], 'returned': [105, 337, 1438, 3533, 3600, 3674], 'basal': [107, 339, 1440, 3602, 3676], 'levels': [108, 340, 1441, 3653, 3677], '3': [110, 342, 1442, 2226, 3588, 3680], 'days': [111, 343, 1443, 3482, 3538, 3667, 4065, 4070], 'after': [112, 344, 1444, 1966, 2001, 2759, 3483, 3539, 3589, 4073], 'RNA': [114, 346, 564, 1969, 1975, 2004, 2094, 2295, 2307, 2352, 3281, 3473, 3851, 3898], 'interference-mediated': [115, 347, 3852], 'knockdown': [116, 348, 1447, 3855], 'diminished': [121, 353, 1451], 'BMP-9-induced': [123, 355, 1453, 3507, 3704, 3865, 4109, 4163, 4192, 4229, 4356, 4364, 4385, 4477], 'progenitor': [128, 196, 360, 428, 503, 1492, 2873, 2967], 'Surprisingly,': [130, 362, 1459], 'a': [131, 214, 363, 446, 467, 847, 1337, 1460, 1510, 1877, 1954, 2113, 2223, 2250, 2266, 2314, 2321, 2488, 2605, 2654, 2661, 3202, 4046, 4133, 4225, 4255, 4324, 4449], 'constitutive': [132, 364, 1461, 4468], 'overexpression': [133, 365, 1462, 4469], 'also': [138, 370, 1466, 3605, 3923, 3989, 4519], 'inhibited': [139, 371, 1467, 4202], 'initiated': [142, 374, 740, 1471], 'by': [143, 375, 741, 1472, 1576, 1873, 2249, 2280, 2438, 2487, 2506, 2561, 2608, 2647, 2781, 2802, 3106, 3115, 3138, 3181, 3193, 3334, 3341, 3354, 3426, 3494, 3562, 3678, 3709, 3732, 3973, 4117, 4203, 4507], 'BMP-9.': [144, 376, 1473], 'Furthermore,': [145, 377], 'BMP-9-regulated': [149, 381], 'is': [152, 384, 466, 739, 2162, 3442, 3453, 3840, 4045, 4281, 4314], 'Smad4-dependent.': [153, 385], 'Overexpression': [154, 386], 'three': [157, 389, 2972, 3119, 3175, 3298, 3420, 3511, 3530, 3557, 3595, 3633, 4243, 4270, 4344, 4398], 'shown': [161, 393, 3198, 3288, 3359, 3499, 3941, 4086, 4233], 'promote': [163, 395], 'cell': [164, 396, 1530, 1936, 4105], 'proliferation': [165, 192, 397, 424, 1488], 'coupled': [168, 400], 'with': [169, 401, 743, 802, 813, 986, 1071, 1295, 1597, 1631, 1663, 1946, 1953, 1994, 2222, 2320, 2454, 2471, 2491, 2495, 2524, 2534, 2544, 2550, 2566, 2590, 2612, 2632, 2751, 2764, 2812, 2971, 2991, 3271, 3379, 3467, 3564, 3644, 3882, 4022, 4178], 'inhibition': [171, 403, 4227, 4294], 'Thus,': [175, 407], 'our': [176, 408, 1072, 3380, 3685, 4391], 'findings': [177, 409, 1073, 3382, 4275, 4339], 'suggest': [178, 410, 4341], 'helix-loop-helix': [182, 414, 556, 1214, 3123], 'may': [184, 220, 416, 452, 1082, 1480, 1517, 4290, 4380], 'promoting': [190, 422, 876, 1486], 'cells': [197, 429, 495, 504, 882, 982, 1493, 1621, 1650, 1931, 1991, 2421, 2521, 2541, 2565, 2587, 2611, 2743, 2761, 2874, 2969, 3254, 3268, 3385, 3464, 3547, 3665, 4075, 4176, 4200], 'must': [202, 434, 1498], 'be': [203, 221, 435, 453, 1083, 1200, 1499, 1518, 4381], 'down-regulated': [204, 436, 1500, 3114], 'during': [205, 437, 1501], 'terminal': [207, 439, 1502], 'committed': [210, 442, 1505, 4042], 'osteoblasts,': [211, 443], 'suggesting': [212, 444], 'balanced': [215, 447, 1511, 1659], 'regulation': [216, 448, 1512], 'critical': [222, 454, 1519], 'lineage-specific': [226, 458, 473], 'formation': [465, 590, 3207, 3839], 'well': [468, 2791, 2989, 4047, 4405], 'orchestrated': [469], 'process': [470], '(1Olsen': [475], 'B.R.': [476], 'Reginato': [477], 'A.M.': [478], 'Wang': [479, 625], 'W.': [480, 598, 892, 937, 1003, 1054, 1714, 1809, 2060, 2682, 2725, 2884, 2929, 3006, 3060, 3153, 3397], 'Annu.': [481, 830], 'Rev.': [482, 686, 831, 4055], 'Cell': [483, 1131, 1240, 1251, 1359, 1370, 1524, 3774, 4429, 4440], 'Dev.': [484, 648, 676], 'Biol.': [485, 1132, 1148, 1252, 1371, 3775, 3791, 4441], '2000;': [486, 840, 1242, 1361, 4431], '16:': [487, 1171, 3814], '191-220Google': [488], 'Scholar).': [489, 631, 661, 715, 735, 843, 959, 1018, 1069, 1185, 1256, 1375, 1769, 1864, 1915, 2075, 2740, 2951, 3021, 3075, 3168, 3239, 3412, 3828, 4062], 'During': [490], 'osteogenesis,': [491], 'pluri-potent': [492], 'differentiate': [496, 513], 'into': [497, 514, 963, 1791, 4012, 4103], 'preosteoblasts': [498, 511], 'rather': [499, 3956], 'than': [500, 3309, 4318], 'serve': [501], 'as': [502, 1267, 1704, 1708, 1804, 1889, 2046, 2132, 2193, 2265, 2637, 2653, 2676, 2988, 2990, 3201, 3321, 3971, 4261, 4263, 4323], 'for': [505, 1315, 1939, 2007, 2077, 2101, 2200, 2273, 2466, 2483, 2529, 2556, 2580, 2594, 2618, 2777, 3277, 3284, 3296, 3346, 3580, 3932], 'myocytes,': [506], 'adipocytes,': [507], 'chondrocytes.': [509], 'These': [510, 3896, 4274], 'then': [512, 798], 'mature': [515], 'osteoblasts': [516, 4043], 'deposit': [518], 'necessary': [520], 'components': [521], 'form': [523, 799], 'bone': [524, 539, 589, 1522, 3206, 3214, 3838], 'matrix': [525], 'allow': [527], 'subsequent': [528, 588], 'mineralization.': [529], '1The': [534], 'abbreviations': [535], 'used': [536, 1880, 2096, 2131, 2138, 2264, 2332, 2636], 'are:': [537], 'BMP,': [538], 'protein;': [541, 553, 557], 'ALP,': [542], 'alkaline': [543, 4030], 'phosphatase;': [544], 'AdBMPs,': [545, 4516], 'adenoviral': [546, 1776, 2754, 4320, 4483], 'vectors': [547, 4484], 'expressing': [548, 1699, 1794, 1885], 'BMPs;': [549], 'GFP,': [550], 'green': [551], 'fluorescent': [552], 'bHLH,': [554], 'basic': [555, 1213, 1277, 1313], 'Id,': [558], 'inhibitor': [559], 'binding/differentiation;': [562], 'RNAi,': [563], 'interference;': [565], 'siRNA,': [566], 'small': [567, 2293], 'interfering': [568, 2294], 'RNA;': [569], 'qRT,': [570], 'quantitative': [571, 3495, 3648], 'real-time': [572, 3496, 3649], 'PCR;': [573], 'TGF-β,': [574], 'transforming': [575], 'growth': [576], 'factor': [577], 'β.': [578], 'regulating': [584], '(2Urist': [591], 'M.R.': [592], 'Nilsson': [593], 'O.': [594], 'Rasmussen': [595], 'J.': [596, 709, 759, 829, 915, 947, 1012, 1063, 1130, 1142, 1147, 1166, 1179, 1239, 1358, 1737, 1754, 1832, 1849, 1900, 2069, 2705, 2734, 2907, 2939, 3015, 3069, 3162, 3406, 3773, 3785, 3790, 3809, 3822, 4428], 'Hirota': [597], 'Lovell': [599], 'T.': [600, 602, 1092, 1111, 1121, 1129, 1231, 1350, 3219, 3735, 3754, 3764, 3772, 4420], 'Schmalzreid': [601], 'Finerman': [603], 'G.A.': [604], 'Clin.': [605], 'Orthop.': [606], '1987;': [607], '214:': [608], '295-304Google': [609], 'Scholar,': [610, 652, 680, 690, 705, 767, 827, 836, 923, 1109, 1136, 1153, 1173, 1236, 1245, 1355, 1364, 1745, 1840, 2713, 2915, 3752, 3779, 3796, 3816, 4425, 4434], '3Wozney': [611], 'J.M.': [612, 707, 1094, 1125, 3737, 3768], 'Rosen': [613, 1122, 3230, 3765], 'V.': [614, 692, 1123, 1140, 3231, 3766, 3783], 'Celeste': [615], 'A.J.': [616], 'Mitsock': [617], 'L.M.': [618], 'Whitters': [619], 'M.J.': [620], 'Kriz': [621], 'R.W.': [622], 'Hewick': [623], 'R.M.': [624, 1155, 3798], 'E.A.': [626], 'Science.': [627, 1232, 1351, 4421], '1988;': [628], '242:': [629], '1528-1534Google': [630], 'BMPs': [632, 667, 719, 859, 988, 991, 2974, 2983, 3032, 3141, 3733], '(4Hogan': [645, 673], 'B.L.': [646, 674, 1157, 1225, 1344, 3800, 4414], 'Genes': [647, 675, 2832], '1996;': [649, 677, 702, 764, 778], '10:': [650, 678], '1580-1594Google': [651, 679], '5Kingsley': [653], 'D.M.': [654], 'Novartis': [655], 'Found.': [656], 'Symp.': [657], '2001;': [658, 1170, 2035, 3093, 3236, 3813, 4059], '232:': [659], '213-222Google': [660], 'At': [662, 1962, 1998, 2756, 3586, 4063], 'least': [663, 3108, 3457], '15': [664, 2530], 'types': [665, 754, 856], 'been': [669, 3197], 'identified': [670, 1206, 1323, 1400], 'humans': [672], '6Reddi': [681], 'A.H.': [682], 'Cytokine': [683], 'Growth': [684], 'Factor': [685], '1997;': [687, 824], '8:': [688], '11-20Google': [689], '7Rosen': [691], 'Thies': [693], 'R.S.': [694], 'Lyons': [695, 3232], 'K.': [696, 776, 819, 3229], 'Ann.': [697], 'N.': [698, 904, 1119, 1726, 1821, 2694, 2896, 3762], 'Y.': [699, 898, 931, 949, 993, 1044, 1175, 1720, 1815, 2050, 2688, 2715, 2890, 2923, 2941, 2996, 3050, 3143, 3387, 3818], 'Acad.': [700, 1101, 1565, 1761, 1856, 1907, 2030, 3088, 3744], 'Sci.': [701, 711, 1102, 1241, 1360, 1566, 1762, 1857, 1908, 2031, 3089, 3745, 4430], '785:': [703], '59-69Google': [704], '8Wozney': [706], 'Eur.': [708], 'Oral.': [710], '1998;': [712, 833, 1570, 1766, 1861, 1912], '106:': [713], '160-166Google': [714], 'Genetic': [716], 'disruptions': [717], 'resulted': [721, 4155, 4246], 'various': [723], 'skeletal': [724], 'extraskeletal': [726], 'developmental': [727], 'abnormalities': [728], '(9Zhao': [729], 'G.Q.': [730], 'Genesis.': [731], '2003;': [732, 920, 1015, 1066, 1182, 1253, 1372, 1742, 1837, 2072, 2710, 2737, 2912, 3018, 3072, 3165, 3409, 3825, 4442], '35:': [733], '43-56Google': [734], 'BMP': [736, 1089, 3326], 'signaling': [737, 965, 1090], 'activity': [738, 853, 2644, 3997, 4033, 4081, 4128, 4170, 4194, 4298], 'interaction': [742], 'heterodimeric': [745, 800], 'complex': [746], 'two': [748, 2981, 3322, 4240, 4267], 'transmembrane': [749], 'serine/threonine': [750], 'kinase': [751], 'receptors,': [752], 'BMPR': [753], 'I': [755], 'II': [757, 2118], '(10Massague': [758], 'Weis-Garcia': [760], 'F.': [761, 1552], 'Cancer': [762], 'Surv.': [763], '27:': [765, 3237], '41-64Google': [766], '11Yamashita': [768], 'H.': [769, 890, 929, 997, 1048, 1712, 1807, 2054, 2680, 2719, 2882, 2921, 3000, 3054, 3147, 3391], 'Ten': [770], 'Dijke': [771, 821], 'P.': [772, 822, 908, 943, 1548, 1730, 1825, 2698, 2900, 2935], 'Heldin': [773], 'C.H.': [774, 817], 'Miyazono': [775, 818], 'Bone.': [777], '19:': [779], '569-574Google': [780], 'Scholar)': [781, 2038, 3096], 'The': [782, 795, 1583, 2105, 2122, 2135, 2170, 2189, 2344, 2358, 2397, 2450, 2499, 2539, 2597, 3169, 3314, 3343, 3485, 3526, 3553, 3925], 'activated': [783], 'receptor': [784], 'kinases': [785], 'phosphorylate': [786], 'transcription': [788, 1216, 1282, 2356], 'factors': [789, 875, 1217], 'Smads': [790, 797], '1,': [791, 3477], '5,': [792], '8.': [794], 'phosphorylated': [796], 'complexes': [801], 'Smad4': [803], 'activate': [805, 1280], 'target': [809, 1284, 2008, 2311, 2336, 3874], 'concert': [812], 'other': [814, 3037], 'co-activators': [815], '(12Heldin': [816], 'ten': [820], 'Nature.': [823], '390:': [825], '465-471Google': [826], '13Massague': [828], 'Biochem.': [832, 1014, 1065, 2071, 2736, 3017, 3071, 3164, 3408], '67:': [834], '753-791Google': [835], '14Wrana': [837], 'J.L.': [838, 1556], 'Cell.': [839, 1013, 1064, 1181, 2070, 2735, 3016, 3070, 3163, 3407, 3824], '100:': [841], '189-192Google': [842], 'conducted': [846, 1395], 'comprehensive': [848], '14': [855, 2857], 'human': [858, 1700], '(i.e.': [860, 1796, 1887, 2975, 2984, 3911, 4493], 'BMP-2': [861], 'BMP-15)': [863], 'both': [883, 2875, 4104], 'vitro': [885, 2302, 2355, 2877, 3894], 'vivo': [888, 2880], '(15Cheng': [889, 1711, 1806, 2679, 2881], 'Jiang': [891, 936, 1002, 1053, 1713, 1808, 2059, 2681, 2724, 2883, 2928, 3005, 3059, 3152, 3396], 'Phillips': [893, 1715, 1810, 2683, 2885], 'F.M.': [894, 1716, 1811, 2684, 2886], 'Haydon': [895, 950, 1008, 1059, 1717, 1812, 2065, 2685, 2730, 2887, 2942, 3011, 3065, 3158, 3402], 'R.C.': [896, 951, 1009, 1060, 1718, 1813, 2066, 2686, 2731, 2888, 2943, 3012, 3066, 3159, 3403], 'Peng': [897, 930, 1719, 1814, 2687, 2889, 2922], 'Zhou': [899, 1721, 1748, 1816, 1843, 1894, 2689, 2891], 'L.': [900, 1550, 1722, 1817, 2690, 2892], 'Luu': [901, 938, 1004, 1055, 1723, 1818, 2061, 2691, 2726, 2893, 2930, 3007, 3061, 3154, 3398], 'H.H.': [902, 939, 1005, 1056, 1724, 1819, 2062, 2692, 2727, 2894, 2931, 3008, 3062, 3155, 3399], 'An': [903, 1725, 1820, 2693, 2895], 'Breyer': [905, 1727, 1822, 2695, 2897], 'B.': [906, 1562, 1728, 1758, 1823, 1853, 1904, 2696, 2898], 'Vanichakarn': [907, 942, 1729, 1824, 2697, 2899, 2934], 'Szatkowski': [909, 940, 1731, 1826, 2699, 2901, 2932], 'J.P.': [910, 912, 941, 1732, 1734, 1827, 1829, 2700, 2702, 2902, 2904, 2933], 'Park': [911, 944, 1006, 1057, 1733, 1828, 2063, 2701, 2728, 2903, 2936, 3009, 3063, 3156, 3400], 'He': [913, 952, 1010, 1061, 1735, 1830, 2067, 2703, 2732, 2905, 2944, 3013, 3067, 3160, 3404], 'T.-C.': [914, 953, 1011, 1062, 1736, 1831, 2068, 2704, 2733, 2906, 2945, 3014, 3068, 3161, 3405], 'Jt.': [917, 1739, 1834, 2707, 2909], 'Surg.': [918, 1740, 1835, 2708, 2910], 'Am.': [919, 1741, 1836, 2709, 2911], '85-A:': [921, 1743, 1838, 2711, 2913], '1544-1552Google': [922, 1744, 1839, 2712, 2914], '16Kang': [924, 2916], 'Q.': [925, 995, 1046, 2052, 2717, 2917, 2998, 3052, 3145, 3389], 'Sun': [926, 1000, 1051, 2057, 2722, 2918, 3003, 3057, 3150, 3394], 'M.H.': [927, 1001, 1052, 2058, 2723, 2919, 3004, 3058, 3151, 3395], 'Cheng': [928, 996, 1047, 2053, 2718, 2920, 2999, 3053, 3146, 3390], 'Montag': [932, 2924], 'A.G.': [933, 2925], 'Deyrup': [934, 2926], 'A.T.': [935, 2927], 'J.Y.': [945, 1007, 1058, 2064, 2729, 2937, 3010, 3064, 3157, 3401], 'Luo': [946, 2938], 'Li': [948, 998, 1049, 2055, 2720, 2940, 3001, 3055, 3148, 3392], 'Gene': [954, 2946, 3714], 'Ther.,.': [955, 2947], '2004;': [956, 2948], '(in': [957, 2949], 'press)Google': [958, 2950], 'To': [960, 2952, 3868], 'gain': [961], 'insights': [962], 'mechanisms': [966, 2955], 'behind': [967, 2956], 'differentiation,': [970], 'analyzed': [973, 3493], 'gene': [975, 1262, 1515, 2337, 3264, 3858, 3938, 3954, 4287], 'profiles': [977], 'preosteoblast': [980, 2966], 'precursor': [981], 'were': [984, 1204, 1406, 1532, 1590, 1622, 1651, 1686, 1787, 1798, 1871, 1932, 1992, 2043, 2082, 2095, 2127, 2270, 2278, 2363, 2422, 2441, 2452, 2522, 2542, 2588, 2635, 2744, 2762, 2810, 3100, 3129, 3178, 3190, 3269, 3301, 3317, 3331, 3351, 3423, 3465, 3543, 3660, 3900, 3929, 4019, 4076, 4124, 4187, 4276, 4305], 'stimulated': [985, 2970], 'versus': [989], 'non-osteogenic': [990], '(17Peng': [992, 1043, 2049, 2995, 3049, 3142, 3386], 'Kang': [994, 1045, 2051, 2716, 2997, 3051, 3144, 3388], 'X.': [999, 1050, 2056, 2721, 3002, 3056, 3149, 3393], '90:': [1016, 1067, 1107, 2073, 2738, 3019, 3073, 3166, 3410, 3750], '1149-1165Google': [1017, 1068, 2074, 2739, 3020, 3074, 3167, 3411], 'BMPs,': [1037, 2858, 3449], 'i.e.': [1038], 'Consistent': [1070, 3643], 'several': [1075, 3723], 'recent': [1076, 3724], 'reports': [1077], 'indicating': [1078, 4253], 'downstream': [1084], 'targets': [1085, 3700], '(18Ogata': [1091, 3734], 'Wozney': [1093, 1124, 3736, 3767], 'Benezra': [1095, 1226, 1248, 1345, 1367, 3738, 4415, 4437], 'R.': [1096, 1227, 1249, 1346, 1368, 2025, 3083, 3739, 4416, 4438], 'Noda': [1097, 3740], 'M.': [1098, 1115, 3741, 3758], 'Proc.': [1099, 1563, 1759, 1854, 1905, 2028, 3086, 3742], 'Natl.': [1100, 1564, 1760, 1855, 1906, 2029, 3087, 3743], 'U.': [1103, 1144, 1567, 1763, 1858, 1909, 2032, 3090, 3746, 3787], 'S.': [1104, 1165, 1546, 1568, 1749, 1764, 1844, 1859, 1895, 1910, 2033, 3091, 3747, 3808], 'A.': [1105, 1113, 1127, 1138, 1146, 1569, 1765, 1860, 1911, 2034, 3092, 3217, 3748, 3756, 3770, 3781, 3789], '1993;': [1106, 3749], '9219-9222Google': [1108, 3751], '19Katagiri': [1110, 3753], 'Yamaguchi': [1112, 3755], 'Komaki': [1114, 3757], 'Abe': [1116, 3759], 'E.': [1117, 3225, 3760], 'Takahashi': [1118, 3761], 'Ikeda': [1120, 3763], 'Fujisawa-Sehara': [1126, 3769], 'Suda': [1128, 3771], '1994;': [1133, 3776], '127:': [1134, 3777], '1755-1766Google': [1135, 3778], '20Hollnagel': [1137, 3780], 'Oehlmann': [1139, 3782], 'Heymer': [1141, 3784], 'Ruther': [1143, 3786], 'Nordheim': [1145, 3788], 'Chem.': [1149, 3792], '1999;': [1150, 3793], '274:': [1151, 3794], '19838-19845Google': [1152, 3795], '21Locklin': [1154, 3797], 'Riggs': [1156, 3799], 'Hicok': [1158, 3801], 'K.C.': [1159, 3802], 'Horton': [1160, 3803], 'H.F.': [1161, 3804], 'Byrne': [1162, 3805], 'M.C.': [1163, 3806], 'Khosla': [1164, 3807], 'Miner.': [1168, 3811], 'Res.': [1169, 3812], '2192-2204Google': [1172, 3815], '22Kang': [1174, 3817], 'Chen': [1176, 3819], 'C.R.': [1177, 3820], 'Massague': [1178, 3821], 'Mol.': [1180, 3823], '11:': [1183, 3826], '915-926Google': [1184, 3827], 'However,': [1186, 3829, 4388], 'remains': [1198], 'defined.': [1201], 'first': [1205, 1394, 2106, 2123, 3930], 'myoblasts,': [1208], 'where': [1209], 'they': [1210], 'prevented': [1211], 'myogenic': [1212], '(bHLH)': [1215], 'from': [1218, 1534, 1688, 2309, 2789, 2815, 3040], 'binding': [1219], 'muscle-specific': [1221], 'regulatory': [1222], 'elements': [1223], '(23Kreider': [1224, 1343, 4413], 'Rovera': [1228, 1347, 4417], 'G.': [1229, 1348, 1554, 2027, 3085, 4418], 'Kadesch': [1230, 1349, 4419], '1992;': [1233, 1352, 4422], '255:': [1234, 1353, 4423], '1700-1702Google': [1235, 1354, 4424], '24Norton': [1237, 1356, 4426], 'J.D.': [1238, 1357, 4427], '113:': [1243, 1362, 4432], '3897-3905Google': [1244, 1363, 4433], '25Ruzinova': [1246, 1365, 4435], 'M.B.': [1247, 1366, 4436], 'Trends': [1250, 1369, 4439], '13:': [1254, 1373, 4443], '410-418Google': [1255, 1374, 4444], 'As': [1257, 3287, 3358, 3498, 3940, 4085, 4232], 'key': [1258], 'regulators': [1259], 'tissue-specific': [1261], 'expression,': [1263], 'bHLH': [1264, 1296], 'function': [1266, 3200], 'obligate': [1268], 'dimers': [1269], 'bind': [1271, 1305], 'through': [1274], 'composite': [1276], 'domains': [1278, 1314], 'containing': [1286, 2569, 2767], 'E-boxes': [1287], '(CANNTG)': [1288], 'their': [1290, 3933, 4525], 'promoters.': [1291], 'dimerize': [1294], 'proteins,': [1297], 'but': [1298, 2847, 3038, 3189, 3339, 3671], 'resultant': [1300, 2359], 'heterodimers': [1301], 'unable': [1303], 'because': [1308, 3208, 3436], 'lack': [1311], 'interaction.': [1317], 'Of': [1318], 'four': [1320], 'mammals,': [1325], 'Id-1': [1326, 2473, 2570], 'ubiquitously': [1330], 'expressed,': [1331], 'whereas': [1332, 4167], 'Id-2': [1333], 'Id-4': [1335], 'exhibit': [1336, 2863, 3212, 4224], 'more': [1338], 'restricted': [1339], 'pattern': [1340, 3028], 'In': [1376, 3429], 'this': [1377, 3430], 'study,': [1378, 3431], 'BMP-stimulated': [1410, 3250, 3307], 'next': [1415, 3414, 3625, 4007], 'readily': [1428, 3179], 'RNAi-mediated': [1446, 2287, 3710], 'progenitors.': [1458], 'Our': [1474], 'results': [1475, 3316, 3646, 3721, 4123], 'demonstrate': [1476, 3691], 'osteoblasts.': [1506], 'This': [1507], 'suggests': [1508], 'formation.': [1523], 'Culture': [1525], 'Chemicals—C2C12': [1527], 'C3H10T1/2': [1529, 1649, 1930, 1990, 3251, 3267, 3376, 3461, 3524, 4016, 4190], 'lines': [1531, 4106], 'obtained': [1533, 4125], 'ATCC': [1536], '(Manassas,': [1537], 'VA).': [1538], 'HCT116': [1539], 'its': [1541], 'Smad4-/-': [1542], 'derivative': [1543], 'line': [1544], '(26Zhou': [1545], 'Buckhaults': [1547], 'Zawel': [1549], 'Bunz': [1551], 'Riggins': [1553], 'Dai': [1555], 'Kern': [1557], 'S.E.': [1558], 'Kinzler': [1559, 1578, 1755, 1850, 1901], 'K.W.': [1560, 1756, 1851, 1902], 'Vogelstein': [1561, 1581, 1757, 1852, 1903], '95:': [1571, 1767, 1862, 1913], '2412-2416Google': [1572], 'Scholar),': [1573, 4445], 'kindly': [1574], 'provided': [1575], 'Ken': [1577], 'Bert': [1580], 'Johns': [1584], 'Hopkins': [1585], 'Medical': [1586], 'Institutions,': [1587], 'Baltimore,': [1588], 'MD,': [1589], 'maintained': [1591, 1623, 1652], 'complete': [1593, 1625, 1943], "McCoy's": [1594], '5A': [1595], 'supplemented': [1596, 1630, 1662, 1945], '10%': [1598, 1632, 1664], 'fetal': [1599, 1633, 1665, 1948], 'calf': [1600, 1634, 1949], 'serum': [1601, 1950, 2552, 2568], '(Mediatech,': [1602], 'Herndon,': [1603], 'VA),': [1604], '100': [1605, 1610, 1636, 1641, 1668, 1673], 'units': [1606, 1637, 1669], 'penicillin,': [1608, 1639, 1671], 'μg': [1611, 1642, 1674], 'streptomycin': [1613, 1644, 1676], '37': [1615, 1646, 1678], '°C': [1616, 2196, 2207, 2212, 2218, 2233, 2238, 2244, 2255, 2528], '5%': [1618], 'CO2.': [1619, 1648, 1680], 'C2C12': [1620, 1928, 2968, 3384, 3463, 3664, 4014, 4143], "Dulbecco's": [1626], 'modified': [1627], "Eagle's": [1628], 'medium': [1629, 1944, 2766, 2788], 'serum,': [1635, 1667], '°Cin5%': [1647, 1679], 'Basal': [1654], 'Medium': [1655], 'Eagle': [1656], "Earle's": [1658], 'salt': [1660], 'solution,': [1661], 'bovine': [1666], 'Unless': [1681], 'indicated': [1682, 1964, 2414, 2753, 3172, 3726], 'otherwise,': [1683], 'all': [1684, 3556, 3619, 4242, 4269, 4330], 'chemicals': [1685], 'purchased': [1687], 'Sigma.': [1689], 'Recombinant': [1690], 'Adenoviral': [1691], 'Vectors': [1692], 'Expressing': [1693], 'Ids—Recombinant': [1696], 'adenovirus': [1697, 1883], '(AdBMP-9)': [1698], '(also': [1702], 'known': [1703, 3325], 'GDF-2)': [1705], 'generated': [1707, 1799], 'previously': [1709, 1890, 2047, 2677, 2853], 'described': [1710, 1805, 1891, 2048, 2678], '27He': [1746, 1841], 'T.C.': [1747, 1842, 1893], 'da': [1750, 1845, 1896], 'Costa': [1751, 1846, 1897], 'L.T.': [1752, 1847, 1898], 'Yu': [1753, 1848, 1899], '2509-2514Google': [1768, 1863, 1914], 'For': [1770, 1876, 4307], 'construction': [1772, 1919], 'vectors,': [1777], 'coding': [1779, 3884], 'regions': [1780, 3885], 'mouse': [1782, 2014, 3257, 4488], 'PCR-amplified': [1788, 1866], 'subcloned': [1790], 'pAdTrack-CMV.': [1792], 'Adenoviruses': [1793], 'AdIds)': [1797], 'using': [1800, 1972, 2112, 2178, 2389, 2507, 3255, 3639, 3984, 4132], 'AdEasy': [1802], 'technology': [1803], 'All': [1865, 2276, 2808], 'fragments': [1867], 'cloning': [1869], 'junctions': [1870], 'verified': [1872], 'sequencing.': [1875], 'control,': [1878], 'analogous': [1882], 'only': [1884, 4114, 4171], 'GFP': [1886, 2342, 2993, 3047, 3312, 3921, 3960, 4119, 4180, 4522], 'AdGFP)': [1888], '(27He': [1892], 'Details': [1916], 'about': [1917], 'vector': [1918], 'available': [1921, 2163, 2403], 'request.': [1923, 2165, 2405], 'Isolation': [1924], 'Total': [1926], 'RNA—Subconfluent': [1927], 'seeded': [1933, 2745], '75-cm2': [1935], 'culture': [1937], 'flasks': [1938], '12': [1940], 'h': [1941, 2000, 2468, 2758], '0.5%': [1947], 'infected': [1952, 1993, 2418, 2750, 3270, 3466, 4021, 4335], 'predetermined': [1955], 'optimal': [1956], 'titer': [1957], 'AdBMP-9': [1959, 1995, 3468, 4024], 'AdGFP.': [1961, 1997, 4026], 'time': [1965, 2415, 4392], 'infection,': [1967, 2002, 2760, 3590, 4321], 'total': [1968, 1974, 2003, 2093, 3472, 4296], 'isolated': [1971, 2006, 3283, 3475], 'RNAgent': [1973], 'isolation': [1976], 'kit': [1977, 2517], '(Promega,': [1978], 'Madison,': [1979], 'WI)': [1980], 'according': [1981, 2392], "manufacturer's": [1984, 2379, 2395], 'instructions.': [1985, 2380, 2396], 'Microarray': [1986, 2010], 'Hybridization': [1987], 'Analysis—Subconfluent': [1989], '30': [1999, 2214, 2229, 2240, 2557, 2595, 3278], 'preparation.': [2009], 'hybridizations': [2011, 3345], '(using': [2012, 2650, 2660], 'Affymetrix': [2013, 3256], 'GeneChip': [2015, 3258], '430A)': [2016], 'significance': [2018], 'microarrays': [2021], '(28Tusher': [2022, 3080], 'V.G.': [2023, 3081], 'Tibshirani': [2024, 3082], 'Chu': [2026, 3084], '98:': [2036, 3094], '5116-5121Google': [2037, 3095], 'dChip': [2040, 3355], 'clustering': [2041, 3356], 'carried': [2044, 2176, 2271, 2387, 3242], 'out': [2045, 2177, 2272, 2388, 3243], 'Hybridizations': [2076], 'BMP-9-': [2078, 3347], 'GFP-treated': [2080, 3349], 'samples': [2081, 2277, 2809, 3308, 3350, 3522, 3573, 3620], 'done': [2083, 2824], 'triplicate.': [2085, 2826], 'Quantitative': [2086], 'Real-time': [2087], 'PCR': [2088, 2317, 2346, 3650], '(qRT-PCR)': [2089], 'Analysis—Ten': [2090], 'micrograms': [2091], 'generate': [2098, 2292, 3869], 'cDNA': [2099, 2108, 2125], 'templates': [2100], 'reverse': [2102, 2119], 'transcriptase': [2103, 2120], 'PCR.': [2104, 3497], 'strand': [2107, 2124], 'synthesis': [2109], 'performed': [2111], 'hexamer': [2114], '(Promega)': [2115, 2776], 'Superscript': [2117], '(Invitrogen).': [2121], 'products': [2126, 3899], 'diluted': [2128, 2261], '10-fold': [2129, 2259], 'qRT-PCR': [2133, 2136, 2173, 3686], 'templates.': [2134], 'respective': [2139, 3952], 'pairs': [2140], 'oligonucleotides': [2142], '(18-mers)': [2143], 'amplify': [2145, 2334], '3′-end': [2147], '(∼120': [2148], 'bp)': [2149], 'genes.': [2156, 2312], 'A': [2157, 2258, 3503, 3916, 3945], 'list': [2158], 'primers': [2161, 2318, 2401], '2T.-C.': [2166, 2406], 'He,': [2167, 2407], 'personal': [2168, 2408], 'communication.': [2169, 2409], 'SYBR': [2171], 'Green-based': [2172], 'Opticon': [2180], 'Engine': [2182], 'thermocycler': [2183], '(M': [2184], 'J': [2185], 'Research,': [2186], 'Waltham,': [2187], 'MA).': [2188], 'cycling': [2190], 'program': [2191], 'follows:': [2194], '94': [2195], '×': [2197, 2208, 2213, 2219, 2234, 2239, 2245], '2': [2198, 3521, 3670], 'min': [2199, 2531, 2620], 'one': [2201, 3443, 3454], 'cycle,': [2202], '4': [2203, 4064], 'cycles': [2204, 2230], '92': [2206, 2232], '20': [2209, 2220, 2235, 2246, 2619, 2768], 's,': [2210, 2215, 2236, 2241, 2247], '68': [2211], '72': [2217, 2243], 's': [2221], 'decrease': [2224], 'degrees/cycle,': [2227], '57': [2237], 'followed': [2248, 2486, 2560, 2780], 'plate': [2251], 'read': [2252], '75': [2254], 'each': [2256, 2274, 2329, 2790, 3036], 'cycle.': [2257], 'serially': [2260], 'pUC19': [2262], 'standard.': [2267], 'Triplicate': [2268], 'reactions': [2269], 'sample.': [2275], 'normalized': [2279, 3293], 'level': [2283, 3487, 3567, 3630], 'glyceraldehyde-3-phosphate': [2285, 3611], 'dehydrogenase.': [2286], 'Silencing': [2288, 3711], 'Expression—To': [2291], '(siRNA)': [2296], 'pools,': [2297], 'employed': [2299], 'Dicer-mediated': [2303], 'digestions': [2304], 'double-stranded': [2306, 3870, 3879, 3897], 'derived': [2308], 'Briefly,': [2313], 'pair': [2315], '(anchored': [2319], 'T7': [2322, 2351], 'promoter': [2323], 'sequence': [2324], '5′-end': [2327], 'primer)': [2330], '(e.g.': [2338, 3574], 'Id-3,or': [2341], 'control).': [2343], 'purified': [2345], 'product': [2347], 'subjected': [2349, 2364, 3901], 'polymerase-mediated': [2353], '(Promega).': [2357], 'double': [2360], 'stranded': [2361], 'RNAs': [2362, 3880], 'recombinant': [2366, 3903, 4482], 'Dicer': [2367, 3904], '(or': [2368], 'RNase': [2369], 'III)': [2370], 'digestion': [2371], '(New': [2372], 'England': [2373], 'Biolabs,': [2374], 'Beverly,': [2375], 'MA)': [2376], 'following': [2377], 'Transfection': [2381], 'siRNA': [2384, 3909, 3918, 3927, 4001, 4010, 4096, 4120, 4148, 4181, 4217, 4244, 4258, 4272, 4303, 4312], 'cocktails': [2385, 4011, 4218, 4245, 4304, 4313], 'LipofectAMINE': [2390], '(Invitrogen)': [2391], 'sequences': [2398], 'Western': [2410, 3640, 3688, 3974, 4508], 'Blotting': [2411], 'Analysis—At': [2412], 'points,': [2416], 'transfected': [2420, 4008, 4177], 'lysed': [2423], 'Laemmli': [2425], 'sample': [2426], 'buffer': [2427, 2458], 'loaded': [2429], 'on': [2430, 3434, 3864, 4228, 4390, 4411], '4-20%': [2431], 'gradient': [2432], 'SDS-polyacrylamide': [2433], 'gels.': [2434], 'After': [2435, 2583], 'being': [2436, 2584], 'resolved': [2437], 'electrophoresis,': [2439], 'transferred': [2442], 'Immobilon-P': [2445], 'membrane': [2446], '(Millipore)': [2447], 'via': [2448, 3892], 'electroblotting.': [2449], 'membranes': [2451], 'blocked': [2453, 2549], 'SuperBlock®': [2455], 'DryBlend': [2456], 'blocking': [2457], 'Tris-buffered': [2460], 'saline': [2461, 2536], '(Pierce)': [2462], 'room': [2464, 2554, 2622], 'temperature': [2465, 2555], '1': [2467, 2778, 3518, 3572, 3668], 'probed': [2470], '(Santa': [2474, 2571], 'Cruz': [2475, 2572], 'Biotechnology),': [2476, 2573], 'antibodies': [2480, 2493, 2577, 2593], '(BD': [2481, 2578], 'Pharmingen)': [2482, 2579], '60': [2484, 2581, 2784], 'min,': [2485, 2558], '30-min': [2489], 'incubation': [2490, 2562], 'secondary': [2492, 2592, 2629], 'conjugated': [2494], 'horseradish': [2496], 'peroxidase': [2497], '(Pierce).': [2498, 2518], 'presence': [2500, 2598], 'detected': [2505, 4083], 'SuperSignal': [2509], 'West': [2510, 2513], 'Pico': [2511], 'Femto': [2514], 'chemiluminescent': [2515], 'substrate': [2516], 'Immunofluorescence': [2519], 'Staining—The': [2520], 'fixed': [2523, 2540, 4077], 'methanol': [2525], '-20': [2527], 'washed': [2533], 'phosphate-buffered': [2535], '2-3': [2537], 'times.': [2538], 'permeabilized': [2543], '1%': [2545], 'Nonidet': [2546], 'P-40/phosphate-buffered': [2547], 'saline,': [2548], 'goat': [2551, 2567], 'min.': [2582, 2596], 'washed,': [2585], 'incubated': [2589, 2763], 'biotin-labeled': [2591], 'examined': [2603], 'under': [2604], 'fluorescence': [2606], 'microscope': [2607], 'incubating': [2609], 'streptavidin-Alexa': [2613], 'Fluor': [2614], '594': [2615], '(Molecular': [2616], 'Probes)': [2617], 'temperature.': [2623], 'Stains': [2624], 'without': [2625], 'primary': [2627], 'and/or': [2628, 2656, 3480], 'antibodies,': [2630], 'control': [2633, 2994, 3048, 3917, 3961], 'IgG,': [2634], 'negative': [2638, 3203], 'controls.': [2639], 'Alkaline': [2640], 'Phosphatase': [2641], 'Activity—Alkaline': [2642], 'phosphatase': [2643, 4031], 'assessed': [2646], 'colorimetric': [2648, 4134], 'assay': [2649, 2659, 2797, 2821, 4135], 'p-nitrophenyl': [2651], 'phosphate': [2652, 2668], 'substrate)': [2655], 'histochemical': [2657], 'staining': [2658, 3981], 'mixture': [2662, 4182, 4259], '0.1': [2664], 'mg/ml': [2665, 2671], 'naphthol': [2666], 'AS-MX': [2667], '0.6': [2670], 'Fast': [2672], 'Blue': [2673], 'BB': [2674], 'salt)': [2675], '17Peng': [2714], 'Proliferation': [2741], 'Assay—C2C12': [2742], '96-well': [2747, 2798], 'plates': [2748], 'vectors.': [2755], '48': [2757], 'fresh': [2765], 'μl': [2769, 2785], 'CellTiter': [2771], '96': [2772], 'AQueous': [2773], 'One': [2774], 'Solution': [2775], 'h,': [2779, 3279], 'transferal': [2782], 'enzyme-linked': [2795], 'immunosorbent': [2796], 'microtiter': [2799], 'plates,': [2800], 'reading': [2803], 'absorbance': [2804], '490': [2806], 'nm.': [2807], 'adjusted': [2811], 'readings': [2814], '(no-cell)': [2817], 'medium-only': [2818], 'control.': [2819, 3313], 'Each': [2820], 'condition': [2822], 'Helix-Loop-Helix': [2831], 'Are': [2833], 'Most': [2836], 'Significantly': [2837], 'Up-regulated': [2838], 'Early': [2839], 'Targets': [2840], 'Osteogenic': [2842, 3705, 4365], 'BMP-9,': [2846], 'Not': [2848], 'Non-osteogenic': [2850], 'BMPs—We': [2851], 'that,': [2855], 'greatest': [2865], 'ability': [2866], 'understand': [2953], 'BMP-mediated': [2957, 3837], 'signaling,': [2959], 'compared': [2961], 'patterns': [2964], 'BMP-9)': [2979], 'inhibitory/non-osteogenic': [2982], 'BMP-3': [2985, 3195, 3209], 'BMP-12),': [2987], 'overall': [3026], 'similar': [3034], 'distinct': [3039], 'those': [3041], 'BMP-3,': [3043], 'BMP-12,': [3044], 'Significance': [3076], 'Analysis': [3077], 'Microarrays': [3079], 'there': [3099, 3992], '203': [3101], 'whose': [3103], 'changed': [3105, 3616], '2-fold,': [3109], '105': [3110], '98': [3113], 'BMPs.': [3117, 3428, 3459], 'Interestingly,': [3118], 'genes,': [3124], 'Id-3,': [3128, 3584], 'top': [3132], '10': [3133], 'microarray': [3170, 3285, 3315], 'data': [3171, 4395], '(up': [3186], '30-fold)': [3188], 'not': [3191, 3340, 3614, 3622, 3841, 3849, 3964, 4004, 4332, 4467, 4512], 'affected': [3192, 4116], 'BMP-3.': [3194], 'regulator': [3204], 'null': [3210], 'mice': [3211], 'higher': [3213, 3303], 'density': [3215], '(29Daluiski': [3216], 'Engstrand': [3218], 'Bahamonde': [3220], 'M.E.': [3221], 'Gamer': [3222], 'L.W.': [3223], 'Agius': [3224], 'Stevenson': [3226], 'S.L.': [3227], 'Cox': [3228], 'K.M.': [3233], 'Nat.': [3234], 'Genet.': [3235], '84-88Google': [3238], 'Next,': [3240], '430A': [3259], '(each': [3260], 'contains': [3261], 'over': [3262], '22,000': [3263], 'probes).': [3265], 'Subconfluent': [3266], 'AdBMP-2,': [3272], 'AdBMP-6,': [3273], 'AdBMP-9,': [3274], 'AdGFP': [3276], 'hybridizations.': [3286], 'Fig.': [3290, 3361, 3501, 3943, 4088, 4235], '1A,': [3291], 'signal': [3294], 'intensities': [3295], 'notably': [3302], 'good': [3319], 'quality,': [3320], 'targets,': [3327], 'Smad6': [3328], 'Smad7,': [3330], 'GFP.': [3342], 'triplicate': [3344], 'further': [3352, 4212, 4293], 'characterized': [3353, 3458], 'analysis.': [3357, 3642], '1B,': [3362], 'BMP-9-stimulated': [3375, 3663], 'cells,': [3377, 4017, 4144, 4331], 'consistent': [3378], 'earlier': [3381], 'verify': [3417], 'whether': [3418, 3847, 4214, 4465], 'indeed': [3424, 3698, 4475], 'focused': [3433], 'yet': [3451], 'it': [3452, 4280], 'Experimentally,': [3460], 'AdGFP,': [3470], '2,': [3478, 3502, 3549], '3,': [3479, 3944, 4089, 4137], '5': [3481, 3537, 4069], 'infection.': [3484, 3540], 'individual': [3489], 'B,': [3505, 3947], 'peaked': [3514], 'day': [3517, 3520, 3571, 3587, 3679], 'baseline': [3535], 'Similar': [3541, 4122, 4185], 'trends': [3542, 4186], 'observed': [3544, 3568], 'C212': [3546], '(Fig.': [3548, 3681, 3977, 3982, 4136, 4183, 4209, 4401], 'C': [3550, 4090], 'D).': [3552], 'highest': [3566], '17-,': [3575], '41-,': [3576], '8-fold': [3578], 'increases': [3579], 'respectively).': [3585], 'had': [3598, 3672], 'almost': [3599, 3673], 'levels.': [3603], 'dehydrogenase': [3612], '(<2-fold)': [3617], '(data': [3621, 4003, 4511], 'shown).': [3623, 4005, 4513], 'blotting': [3641, 3689, 3975, 4509], 'analysis,': [3651], 'elevated': [3661], '2E).': [3682], 'Taken': [3683], 'together,': [3684], 'analyses': [3690], 'signaling.': [3703, 4358, 4387], 'Differentiation': [3706, 4366], 'Is': [3707], 'Disrupted': [3708], 'Preosteoblast': [3717, 4369], 'Progenitor': [3718, 4370], 'Cells—The': [3719, 4371], 'above': [3720, 4372], 'studies': [3725], 'regulated': [3731], 'actual': [3831], 'known.': [3842], 'depletion': [3853], 'would': [3860, 4223, 4328, 4474], 'any': [3862], 'effect': [3863, 4408], 'siRNAs': [3871, 3949, 3962], 'efficiently': [3873], 'transcripts,': [3876], 'synthesized': [3878], 'corresponding': [3881], 'transcription.': [3895], 'digestion,': [3905], 'resulting': [3906], 'pools': [3910, 3928, 4002, 4097, 4149], 'siId-1,': [3912, 4196], 'siId-2,': [3913, 4197], 'siId-3).': [3915], 'pool': [3919], 'targeting': [3920, 4098, 4150, 4219], 'prepared.': [3924], 'produced': [3926], 'tested': [3931, 4213], 'efficiency': [3934, 4289], 'specificity': [3936], 'silencing.': [3939], 'targeted': [3950], 'specifically,': [3957], 'did': [3963], 'affect': [3965, 4329], '3A)': [3978], 'immunofluorescence': [3980], '3B)': [3983], 'specific': [3985], 'antibodies.': [3987], 'confirmed': [3990, 4506], 'no': [3994], 'detectable': [3995], 'cross-targeting': [3996], 'subconfluent': [4013], 'which': [4018, 4112], 'subsequently': [4020], 'either': [4023], 'determined': [4028], '(ALP)': [4032], 'transfected/infected': [4036], 'ALP': [4038, 4080, 4110, 4127, 4164, 4169, 4193, 4230, 4251, 4297], 'elevates': [4040], 'established': [4048, 4406], 'marker': [4049], 'osteogenesis': [4052], '(30Aubin': [4053], 'J.E.': [4054], 'Endocr.': [4056], 'Metab.': [4057], 'Disord.': [4058], '2:': [4060], '81-94Google': [4061], '(for': [4066, 4071], 'C2C12)': [4067], 'C3H10T1/2)': [4072], 'transfection/infection,': [4074], 'histochemically.': [4084], 'D,': [4092], 'introduction': [4094, 4145], 'reduced': [4107], 'activity,': [4111, 4165, 4252], 'marginally': [4115], 'mixture.': [4121], 'when': [4126, 4299], 'quantitatively': [4130], 'measured': [4131], 'E': [4138], 'F).': [4140], 'Specifically,': [4141], '∼90,': [4157], '93,': [4158, 4205], '86%': [4160], 'decreases': [4161], 'respectively,': [4166], 'decreased': [4172], '∼10%': [4173], '3E).': [4184], 'seen': [4188], 'cells;': [4191], 'siId-3-transfected': [4199], '∼85,': [4204], '91%,': [4207], 'respectively': [4208], '3F).': [4210], 'combinations': [4215, 4238, 4265, 4300], 'different': [4220], 'greater': [4226], 'activity.': [4231], '3G,': [4236], '∼80-90%': [4248], 'reduction': [4249], 'single': [4256], 'efficient': [4262, 4317], 'cocktails.': [4273], 'somewhat': [4277], 'surprising,': [4278], 'although': [4279], 'possible': [4282], 'difference': [4285], 'transfer': [4288], 'limit': [4291], 'used.': [4306], 'example,': [4308], 'transfection': [4310], 'likely': [4315], 'less': [4316], 'AdBMP-9-mediated': [4319], 'secreted': [4325], 'protein': [4326], 'just': [4333], 'Nevertheless,': [4337], 'strongly': [4340], 'Constitutive': [4359], 'Inhibits': [4362], 'RNAi': [4373], 'experiments': [4374], 'indicate': [4375], 'mediators': [4383], 'based': [4389], 'course': [4393], '1B)': [4402], 'inhibitory': [4407], 'Ids': [4410], 'myogenesis': [4412], 'hypothesized': [4447], 'prolonged': [4450], 'could': [4456], 'inhibit': [4457, 4476], 'constructed': [4481], 'expressed': [4486, 4520], 'AdId-1,': [4494], 'AdId-2,': [4495], 'AdId-3),': [4497], 'respectively.': [4498], 'Adenovirus-mediated': [4499], 'Like': [4514], 'AdIds': [4518], 'reporter': [4523], 'so': [4524], 'transduction': [4526], 'efficie': [4527]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2129292492', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 17}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 21}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 14}, {'year': 2013, 'cited_by_count': 26}, {'year': 2012, 'cited_by_count': 11}], 'updated_date': '2025-01-09T07:05:04.635578', 'created_date': '2016-06-24'}
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