Amyloid Precursor Protein Processing and Alzheimer's Disease

Name: Work Video:
Duration: 3 min 30 s
Richard O‘Brien; Philip C. Wong
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'that': [39], 'physiologic': [40], 'generation': [41], 'neurotoxic': [44], 'Aβ': [45, 104, 123], 'from': [47, 127], 'sequential': [48, 89], 'amyloid': [49], 'precursor': [50], '(APP)': [52], 'proteolysis': [53], 'crucial': [56, 137], 'step': [57], 'in': [58, 73, 78, 106, 119], 'development': [60, 140], 'AD.': [62, 146], 'APP': [63, 120, 133], 'a': [65, 79, 86], 'single-pass': [66], 'transmembrane': [67], 'expressed': [69], 'at': [70], 'high': [71], 'levels': [72], 'metabolized': [77], 'rapid': [80], 'highly': [82], 'complex': [83], 'fashion': [84], 'series': [87], 'proteases,': [90], 'including': [91], 'intramembranous': [93], 'γ-secretase': [94], 'complex,': [95], 'which': [96], 'also': [97], 'process': [98], 'other': [99], 'key': [100], 'regulatory': [101], 'molecules.': [102], 'Why': [103], 'accumulates': [105], 'brains': [108], 'elderly': [110], 'individuals': [111], 'unclear': [113], 'but': [114], 'could': [115], 'relate': [116], 'to': [117, 138, 144], 'changes': [118], 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