Title: Virus‐Mimetic Cytoplasm‐Cleavable Magnetic/Silica Nanoclusters for Enhanced Gene Delivery to Mesenchymal Stem Cells
Abstract: Angewandte Chemie International EditionVolume 52, Issue 43 p. 11278-11281 Communication Virus-Mimetic Cytoplasm-Cleavable Magnetic/Silica Nanoclusters for Enhanced Gene Delivery to Mesenchymal Stem Cells† Naveen Gandra, Naveen Gandra Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, 101 Stephenson Parkway, Room 3310, Norman, OK 73019-5300 (USA) These authors contributed equally to this work.Search for more papers by this authorDong-Dong Wang, Dong-Dong Wang Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, 101 Stephenson Parkway, Room 3310, Norman, OK 73019-5300 (USA) These authors contributed equally to this work.Search for more papers by this authorYe Zhu, Ye Zhu Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, 101 Stephenson Parkway, Room 3310, Norman, OK 73019-5300 (USA)Search for more papers by this authorProf. Chuanbin Mao, Corresponding Author Prof. Chuanbin Mao [email protected] Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, 101 Stephenson Parkway, Room 3310, Norman, OK 73019-5300 (USA)Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, 101 Stephenson Parkway, Room 3310, Norman, OK 73019-5300 (USA)Search for more papers by this author Naveen Gandra, Naveen Gandra Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, 101 Stephenson Parkway, Room 3310, Norman, OK 73019-5300 (USA) These authors contributed equally to this work.Search for more papers by this authorDong-Dong Wang, Dong-Dong Wang Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, 101 Stephenson Parkway, Room 3310, Norman, OK 73019-5300 (USA) These authors contributed equally to this work.Search for more papers by this authorYe Zhu, Ye Zhu Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, 101 Stephenson Parkway, Room 3310, Norman, OK 73019-5300 (USA)Search for more papers by this authorProf. Chuanbin Mao, Corresponding Author Prof. Chuanbin Mao [email protected] Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, 101 Stephenson Parkway, Room 3310, Norman, OK 73019-5300 (USA)Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, 101 Stephenson Parkway, Room 3310, Norman, OK 73019-5300 (USA)Search for more papers by this author First published: 28 August 2013 https://doi.org/10.1002/anie.201301113Citations: 67 † We would like to thank the National Science Foundation (CBET-0854465, CBET-0854414 and DMR-0847758), National Institutes of Health (4R03AR056848-03, 1R21EB015190-02, and 5R01HL092526-02), Department of Defense Peer Reviewed Medical Research Program (W81XWH-12-1-0384), Oklahoma Center for the Advancement of Science and Technology (HR11-006), and Oklahoma Center for Adult Stem Cell Research (434003) for their generous financial support. We also want to thank Dr. Haibao Zhu and Dr. Gopal Abbineni for their kind help during experiments. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract It does get in: Phage is made of DNA as a core and protein as a coat, and it can transfer DNA into host cells with high efficiency. Phage-mimetic gene transfer to hard-to-transfect mesenchymal stem cells (MSCs) was achieved using virus-mimetic magnetic silica nanoclusters (VMSNCs). The VMSNCs bear MSC-homing phage-borne protein on the surface and encapsulate DNA inside, promoting the transfer of DNA into MSCs. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Filename Description anie_201301113_sm_miscellaneous_information.pdf1.1 MB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. References 1 1aA. A. Kocher, M. D. Schuster, M. J. Szabolcs, S. Takuma, D. Burkhoff, J. Wang, S. Homma, N. M. Edwards, S. Itescu, Nat. 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