Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2128484737', 'doi': 'https://doi.org/10.1128/aac.00756-10', 'title': 'Activities of NXL104 Combinations with Ceftazidime and Aztreonam against Carbapenemase-Producing <i>Enterobacteriaceae</i>', 'display_name': 'Activities of NXL104 Combinations with Ceftazidime and Aztreonam against Carbapenemase-Producing <i>Enterobacteriaceae</i>', 'publication_year': 2010, 'publication_date': '2010-11-02', 'ids': {'openalex': 'https://openalex.org/W2128484737', 'doi': 'https://doi.org/10.1128/aac.00756-10', 'mag': '2128484737', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21041502', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3019623'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/aac.00756-10', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1128/aac.00756-10', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5072423246', 'display_name': 'David M. Livermore', 'orcid': 'https://orcid.org/0000-0002-9856-3703'}, 'institutions': [], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'David M. Livermore', 'raw_affiliation_strings': ['Antibiotic Resistance Monitoring & Reference Laboratory, HPA Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Antibiotic Resistance Monitoring & Reference Laboratory, HPA Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, United Kingdom', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047369494', 'display_name': 'Shazad Mushtaq', 'orcid': 'https://orcid.org/0000-0002-3908-8332'}, 'institutions': [], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Shazad Mushtaq', 'raw_affiliation_strings': ['Antibiotic Resistance Monitoring & Reference Laboratory, HPA Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Antibiotic Resistance Monitoring & Reference Laboratory, HPA Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, United Kingdom', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060608792', 'display_name': 'Marina Warner', 'orcid': 'https://orcid.org/0000-0001-9310-3022'}, 'institutions': [], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Marina Warner', 'raw_affiliation_strings': ['Antibiotic Resistance Monitoring & Reference Laboratory, HPA Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Antibiotic Resistance Monitoring & Reference Laboratory, HPA Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, United Kingdom', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101647932', 'display_name': 'Jiancheng Zhang', 'orcid': 'https://orcid.org/0000-0002-2820-0851'}, 'institutions': [], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Jiancheng Zhang', 'raw_affiliation_strings': ['Antibiotic Resistance Monitoring & Reference Laboratory, HPA Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Antibiotic Resistance Monitoring & Reference Laboratory, HPA Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, United Kingdom', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045790400', 'display_name': 'Sunil Maharjan', 'orcid': 'https://orcid.org/0000-0002-0523-4610'}, 'institutions': [], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Sunil Maharjan', 'raw_affiliation_strings': ['Antibiotic Resistance Monitoring & Reference Laboratory, HPA Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Antibiotic Resistance Monitoring & Reference Laboratory, HPA Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, United Kingdom', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007274804', 'display_name': 'Michel Doumith', 'orcid': 'https://orcid.org/0000-0002-8004-0314'}, 'institutions': [], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Michel Doumith', 'raw_affiliation_strings': ['Antibiotic Resistance Monitoring & Reference Laboratory, HPA Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Antibiotic Resistance Monitoring & Reference Laboratory, HPA Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, United Kingdom', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5000013450', 'display_name': 'Neil Woodford', 'orcid': 'https://orcid.org/0000-0003-1396-8953'}, 'institutions': [], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Neil Woodford', 'raw_affiliation_strings': ['Antibiotic Resistance Monitoring & Reference Laboratory, HPA Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Antibiotic Resistance Monitoring & Reference Laboratory, HPA Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, United Kingdom', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 10.219, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 247, 'citation_normalized_percentile': {'value': 0.999496, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '55', 'issue': '1', 'first_page': '390', 'last_page': '394'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10147', 'display_name': 'Global Challenge of Antibiotic Resistance in Bacteria', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1313', 'display_name': 'Molecular Medicine'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10147', 'display_name': 'Global Challenge of Antibiotic Resistance in Bacteria', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1313', 'display_name': 'Molecular Medicine'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13849', 'display_name': 'Outbreak of Cronobacter sakazakii Infections', 'score': 0.9874, 'subfield': {'id': 'https://openalex.org/subfields/1310', 'display_name': 'Endocrinology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11578', 'display_name': 'Genomics and Pathogenicity of Plant Pathogenic Bacteria', 'score': 0.9863, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/aztreonam', 'display_name': 'Aztreonam', 'score': 0.9844895}, {'id': 'https://openalex.org/keywords/carbapenem', 'display_name': 'Carbapenem', 'score': 0.52593714}, {'id': 'https://openalex.org/keywords/carbapenemases', 'display_name': 'Carbapenemases', 'score': 0.507934}], 'concepts': [{'id': 'https://openalex.org/C2780416669', 'wikidata': 'https://www.wikidata.org/wiki/Q418546', 'display_name': 'Aztreonam', 'level': 5, 'score': 0.9844895}, {'id': 'https://openalex.org/C2776968632', 'wikidata': 'https://www.wikidata.org/wiki/Q808845', 'display_name': 'Ceftazidime', 'level': 4, 'score': 0.9218326}, {'id': 'https://openalex.org/C2778910516', 'wikidata': 'https://www.wikidata.org/wiki/Q380136', 'display_name': 'Enterobacteriaceae', 'level': 4, 'score': 0.757245}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.7146193}, {'id': 'https://openalex.org/C2776685102', 'wikidata': 'https://www.wikidata.org/wiki/Q410897', 'display_name': 'Carbapenem', 'level': 3, 'score': 0.52593714}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.42367855}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.40798628}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.32860684}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.20804295}, {'id': 'https://openalex.org/C2779631663', 'wikidata': 'https://www.wikidata.org/wiki/Q425152', 'display_name': 'Imipenem', 'level': 4, 'score': 0.20424005}, {'id': 'https://openalex.org/C547475151', 'wikidata': 'https://www.wikidata.org/wiki/Q25419', 'display_name': 'Escherichia coli', 'level': 3, 'score': 0.18417251}, {'id': 'https://openalex.org/C94665300', 'wikidata': 'https://www.wikidata.org/wiki/Q63391344', 'display_name': 'Antibiotic resistance', 'level': 3, 'score': 0.099253386}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.098490655}, {'id': 'https://openalex.org/C2777637488', 'wikidata': 'https://www.wikidata.org/wiki/Q31856', 'display_name': 'Pseudomonas aeruginosa', 'level': 3, 'score': 0.064031124}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.035821825}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000900', 'descriptor_name': 'Anti-Bacterial Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D053961', 'descriptor_name': 'Azabicyclo Compounds', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D001398', 'descriptor_name': 'Aztreonam', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D002442', 'descriptor_name': 'Ceftazidime', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D004755', 'descriptor_name': 'Enterobacteriaceae', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D004755', 'descriptor_name': 'Enterobacteriaceae', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D001618', 'descriptor_name': 'beta-Lactamases', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D000900', 'descriptor_name': 'Anti-Bacterial Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053961', 'descriptor_name': 'Azabicyclo Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001398', 'descriptor_name': 'Aztreonam', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002442', 'descriptor_name': 'Ceftazidime', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004338', 'descriptor_name': 'Drug Combinations', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004755', 'descriptor_name': 'Enterobacteriaceae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008826', 'descriptor_name': 'Microbial Sensitivity Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001618', 'descriptor_name': 'beta-Lactamases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/aac.00756-10', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3019623', 'pdf_url': 'https://europepmc.org/articles/pmc3019623?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019623', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21041502', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/aac.00756-10', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 21, 'referenced_works': ['https://openalex.org/W1895007034', 'https://openalex.org/W1902535075', 'https://openalex.org/W1983739993', 'https://openalex.org/W2004233129', 'https://openalex.org/W2062362165', 'https://openalex.org/W2074669461', 'https://openalex.org/W2101382329', 'https://openalex.org/W2103171109', 'https://openalex.org/W2104172130', 'https://openalex.org/W2112851214', 'https://openalex.org/W2114559245', 'https://openalex.org/W2128323748', 'https://openalex.org/W2132457720', 'https://openalex.org/W2137269542', 'https://openalex.org/W2137527487', 'https://openalex.org/W2140469508', 'https://openalex.org/W2154556219', 'https://openalex.org/W2154955845', 'https://openalex.org/W2165994761', 'https://openalex.org/W2166683258', 'https://openalex.org/W85187135'], 'related_works': ['https://openalex.org/W4232680661', 'https://openalex.org/W315027375', 'https://openalex.org/W2531064147', 'https://openalex.org/W2312875682', 'https://openalex.org/W2134027256', 'https://openalex.org/W2104934831', 'https://openalex.org/W2095753257', 'https://openalex.org/W2066332815', 'https://openalex.org/W1996456844', 'https://openalex.org/W1975418104'], 'abstract_inverted_index': {'ABSTRACT': [0], 'Combinations': [1], 'of': [2, 13, 29], 'NXL104': [3], 'with': [4, 22, 27, 45, 68], 'ceftazidime': [5], 'and': [6, 31, 39, 63], 'aztreonam': [7], 'were': [8, 52], 'tested': [9], 'against': [10, 20, 41, 57], 'carbapenem-resistant': [11], 'members': [12], 'the': [14, 23, 46], 'Enterobacteriaceae': [15], '.': [16], 'Ceftazidime-NXL104': [17], 'was': [18, 55], 'active': [19, 56], 'strains': [21], 'OXA-48': [24], 'enzyme': [25, 38], 'or': [26, 36], 'combinations': [28], 'impermeability': [30], 'an': [32], 'extended-spectrum': [33], 'β-lactamase': [34], '(ESBL)': [35], 'AmpC': [37], 'also': [40], 'most': [42], 'Klebsiella': [43], 'spp.': [44], 'KPC': [47], 'enzyme,': [48], 'but': [49], 'metallo-β-lactamase': [50], 'producers': [51, 60], 'resistant.': [53], 'Aztreonam-NXL104': [54], 'all': [58], 'carbapenemase': [59], 'at': [61], '4': [62, 64], 'μg/ml,': [65], 'including': [66], 'those': [67], 'metallo-β-lactamases.': [69]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2128484737', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 12}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 14}, {'year': 2019, 'cited_by_count': 16}, {'year': 2018, 'cited_by_count': 17}, {'year': 2017, 'cited_by_count': 17}, {'year': 2016, 'cited_by_count': 22}, {'year': 2015, 'cited_by_count': 38}, {'year': 2014, 'cited_by_count': 25}, {'year': 2013, 'cited_by_count': 24}, {'year': 2012, 'cited_by_count': 18}], 'updated_date': '2024-09-17T16:28:40.607745', 'created_date': '2016-06-24'}