Publication Information

{'id': 'https://openalex.org/W2128387421', 'doi': 'https://doi.org/10.1093/nar/27.19.3792', 'title': 'Plasmid DNA size does not affect the physicochemical properties of lipoplexes but modulates gene transfer efficiency', 'display_name': 'Plasmid DNA size does not affect the physicochemical properties of lipoplexes but modulates gene transfer efficiency', 'publication_year': 1999, 'publication_date': '1999-10-01', 'ids': {'openalex': 'https://openalex.org/W2128387421', 'doi': 'https://doi.org/10.1093/nar/27.19.3792', 'mag': '2128387421', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10481017', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/148641'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/nar/27.19.3792', 'pdf_url': 'https://academic.oup.com/nar/article-pdf/27/19/3792/3603656/27-19-3792.pdf', 'source': {'id': 'https://openalex.org/S134668137', 'display_name': 'Nucleic Acids Research', 'issn_l': '0305-1048', 'issn': ['0305-1048', '1362-4954', '1362-4962'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/nar/article-pdf/27/19/3792/3603656/27-19-3792.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5066202800', 'display_name': 'P Kreiss', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': True, 'raw_author_name': 'P Kreiss', 'raw_affiliation_strings': ['UMR 133 Centre National de la Recherche Scientifique-Rhône Poulenc Rorer, 13 Quai Jules Guesde, BP 14, 94403 Vitry sur Seine, France'], 'affiliations': [{'raw_affiliation_string': 'UMR 133 Centre National de la Recherche Scientifique-Rhône Poulenc Rorer, 13 Quai Jules Guesde, BP 14, 94403 Vitry sur Seine, France', 'institution_ids': ['https://openalex.org/I1294671590']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5066202800'], 'corresponding_institution_ids': ['https://openalex.org/I1294671590'], 'apc_list': {'value': 3630, 'currency': 'USD', 'value_usd': 3630, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.29, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 263, 'citation_normalized_percentile': {'value': 0.953522, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '27', 'issue': '19', 'first_page': '3792', 'last_page': '3798'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10725', 'display_name': 'RNA Interference and Gene Delivery', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10725', 'display_name': 'RNA Interference and Gene Delivery', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10432', 'display_name': 'DNA and Nucleic Acid Chemistry', 'score': 0.9943, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10521', 'display_name': 'RNA and protein synthesis mechanisms', 'score': 0.9943, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cationic-polymerization', 'display_name': 'Cationic polymerization', 'score': 0.5113315}], 'concepts': [{'id': 'https://openalex.org/C22744801', 'wikidata': 'https://www.wikidata.org/wiki/Q172778', 'display_name': 'Plasmid', 'level': 3, 'score': 0.8478941}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.7478974}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.68066764}, {'id': 'https://openalex.org/C54009773', 'wikidata': 'https://www.wikidata.org/wiki/Q1429031', 'display_name': 'Transfection', 'level': 3, 'score': 0.6198774}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.5880408}, {'id': 'https://openalex.org/C183882617', 'wikidata': 'https://www.wikidata.org/wiki/Q3046749', 'display_name': 'Cationic polymerization', 'level': 2, 'score': 0.5113315}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.4136268}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.36651492}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.324504}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.19152912}, {'id': 'https://openalex.org/C188027245', 'wikidata': 'https://www.wikidata.org/wiki/Q750446', 'display_name': 'Polymer chemistry', 'level': 1, 'score': 0.05918607}], 'mesh': [{'descriptor_ui': 'D004269', 'descriptor_name': 'DNA, Bacterial', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D018014', 'descriptor_name': 'Gene Transfer Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008055', 'descriptor_name': 'Lipids', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D010957', 'descriptor_name': 'Plasmids', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D011073', 'descriptor_name': 'Polyamines', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D016475', 'descriptor_name': '3T3 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003102', 'descriptor_name': 'Colloids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004269', 'descriptor_name': 'DNA, Bacterial', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D004269', 'descriptor_name': 'DNA, Bacterial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008055', 'descriptor_name': 'Lipids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008854', 'descriptor_name': 'Microscopy, Electron', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010316', 'descriptor_name': 'Particle Size', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010957', 'descriptor_name': 'Plasmids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010957', 'descriptor_name': 'Plasmids', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D011073', 'descriptor_name': 'Polyamines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011122', 'descriptor_name': 'Polyphosphates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014965', 'descriptor_name': 'X-Rays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/nar/27.19.3792', 'pdf_url': 'https://academic.oup.com/nar/article-pdf/27/19/3792/3603656/27-19-3792.pdf', 'source': {'id': 'https://openalex.org/S134668137', 'display_name': 'Nucleic Acids Research', 'issn_l': '0305-1048', 'issn': ['0305-1048', '1362-4954', '1362-4962'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc148641', 'pdf_url': 'https://europepmc.org/articles/pmc148641?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC148641', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10481017', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/nar/27.19.3792', 'pdf_url': 'https://academic.oup.com/nar/article-pdf/27/19/3792/3603656/27-19-3792.pdf', 'source': {'id': 'https://openalex.org/S134668137', 'display_name': 'Nucleic Acids Research', 'issn_l': '0305-1048', 'issn': ['0305-1048', '1362-4954', '1362-4962'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 1, 'referenced_works': ['https://openalex.org/W2144634347'], 'related_works': ['https://openalex.org/W606133901', 'https://openalex.org/W4386701586', 'https://openalex.org/W2386244931', 'https://openalex.org/W2385956243', 'https://openalex.org/W2372164627', 'https://openalex.org/W2371793935', 'https://openalex.org/W2073526740', 'https://openalex.org/W2058102014', 'https://openalex.org/W2055437287', 'https://openalex.org/W2003677112'], 'abstract_inverted_index': {'Clinical': [0], 'applications': [1], 'of': [2, 10, 45, 61, 72, 84, 106, 110, 118, 137, 147, 171], 'gene': [3, 12, 163, 188], 'therapy': [4], 'mainly': [5], 'depend': [6, 153], 'on': [7, 76, 154], 'the': [8, 42, 62, 77, 82, 103, 107, 111, 115, 119, 124, 132, 142, 148, 159, 169, 179, 193], 'development': [9], 'efficient': [11], 'transfer': [13, 164, 189], 'vectors.': [14], 'Large': [15], 'DNA': [16, 71, 108, 156, 173], 'molecules': [17, 174], 'can': [18], 'only': [19], 'be': [20], 'transfected': [21], 'into': [22], 'cells': [23], 'by': [24, 65, 102, 123, 131, 168], 'using': [25], 'synthetic': [26], 'vectors': [27], 'such': [28], 'as': [29], 'cationic': [30, 46, 112, 125], 'lipids': [31], 'and': [32, 92, 98, 109, 127, 144], 'polymers.': [33], 'The': [34, 58, 134, 182], 'present': [35], 'investigation': [36], 'was': [37, 121, 140, 166], 'therefore': [38], 'designed': [39], 'to': [40, 54, 89], 'explore': [41], 'physicochemical': [43, 104], 'properties': [44], 'lipid-DNA': [47], 'particles,': [48], 'with': [49, 69], 'plasmids': [50], 'ranging': [51], 'from': [52], '900': [53], '52': [55], '500': [56], 'bp.': [57], 'colloidal': [59], 'stability': [60], 'lipoplexes': [63], 'formed': [64], 'complexing': [66], 'lipopolyamine': [67], 'micelles': [68], 'plasmid': [70, 155, 172, 195], 'various': [73], 'lengths,': [74], 'depending': [75], 'charge': [78], 'ratio,': [79], 'resulted': [80], 'in': [81], 'formation': [83], 'three': [85], 'domains,': [86], 'respectively': [87], 'corresponding': [88], 'negatively,': [90], 'neutrally': [91], 'positively': [93], 'charged': [94], 'lipoplexes.': [95], 'Lipoplex': [96], 'morphology': [97, 130], 'structure': [99, 120], 'were': [100, 176, 190], 'determined': [101, 122], 'characteristics': [105], 'lipid.': [113], 'Thus,': [114], 'lamellar': [116], 'spacing': [117], 'lipid': [126, 180], 'its': [128], 'spherical': [129], 'DNA.': [133, 196], 'main': [135], 'result': [136], 'this': [138], 'study': [139], 'that': [141], 'morphological': [143], 'structural': [145], 'features': [146], 'lipopolyamine-DNA': [149, 185], 'complexes': [150, 186], 'did': [151], 'not': [152], 'length.': [157], 'On': [158], 'other': [160], 'hand,': [161], 'their': [162], 'capacity': [165], 'affected': [167], 'size': [170], 'which': [175], 'sandwiched': [177], 'between': [178], 'bilayers.': [181], 'most': [183], 'effective': [184], 'for': [187], 'those': [191], 'containing': [192], 'shortest': [194]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2128387421', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 14}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 12}, {'year': 2019, 'cited_by_count': 16}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 13}, {'year': 2016, 'cited_by_count': 11}, {'year': 2015, 'cited_by_count': 10}, {'year': 2014, 'cited_by_count': 16}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 11}], 'updated_date': '2024-12-13T17:06:25.048707', 'created_date': '2016-06-24'}