Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2128314375', 'doi': 'https://doi.org/10.1586/erc.10.90', 'title': 'Update on the clinical development of cangrelor', 'display_name': 'Update on the clinical development of cangrelor', 'publication_year': 2010, 'publication_date': '2010-07-30', 'ids': {'openalex': 'https://openalex.org/W2128314375', 'doi': 'https://doi.org/10.1586/erc.10.90', 'mag': '2128314375', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20670184'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1586/erc.10.90', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S108504264', 'display_name': 'Expert Review of Cardiovascular Therapy', 'issn_l': '1477-9072', 'issn': ['1477-9072', '1744-8344'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101967915', 'display_name': 'Masafumi Ueno', 'orcid': 'https://orcid.org/0000-0002-3613-660X'}, 'institutions': [{'id': 'https://openalex.org/I94062374', 'display_name': 'Florida College', 'ror': 'https://ror.org/010bgev76', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I94062374']}, {'id': 'https://openalex.org/I33213144', 'display_name': 'University of Florida', 'ror': 'https://ror.org/02y3ad647', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I33213144']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Masafumi Ueno', 'raw_affiliation_strings': ['Department of Medicine, Division of Cardiology, University of Florida College of Medicine-Jacksonville, Shands Jacksonville, 655 West 8th Street, Jacksonville, FL 32209, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Division of Cardiology, University of Florida College of Medicine-Jacksonville, Shands Jacksonville, 655 West 8th Street, Jacksonville, FL 32209, USA.', 'institution_ids': ['https://openalex.org/I94062374', 'https://openalex.org/I33213144']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015362856', 'display_name': 'José Luis Ferreiro', 'orcid': 'https://orcid.org/0000-0003-1202-9575'}, 'institutions': [{'id': 'https://openalex.org/I33213144', 'display_name': 'University of Florida', 'ror': 'https://ror.org/02y3ad647', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I33213144']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'José Luis Ferreiro', 'raw_affiliation_strings': ['University of Florida, Gainesville, United States'], 'affiliations': [{'raw_affiliation_string': 'University of Florida, Gainesville, United States', 'institution_ids': ['https://openalex.org/I33213144']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5040418600', 'display_name': 'Dominick J. Angiolillo', 'orcid': 'https://orcid.org/0000-0001-8451-2131'}, 'institutions': [{'id': 'https://openalex.org/I94062374', 'display_name': 'Florida College', 'ror': 'https://ror.org/010bgev76', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I94062374']}, {'id': 'https://openalex.org/I33213144', 'display_name': 'University of Florida', 'ror': 'https://ror.org/02y3ad647', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I33213144']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dominick J Angiolillo', 'raw_affiliation_strings': ['Department of Medicine – Division of Cardiology, University of Florida College of Medicine-Jacksonville, Shands Jacksonville, 655 West 8th Street, Jacksonville, FL 32209, USA; [email protected]'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine – Division of Cardiology, University of Florida College of Medicine-Jacksonville, Shands Jacksonville, 655 West 8th Street, Jacksonville, FL 32209, USA; [email protected]', 'institution_ids': ['https://openalex.org/I94062374', 'https://openalex.org/I33213144']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.758, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 34, 'citation_normalized_percentile': {'value': 0.609465, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '8', 'issue': '8', 'first_page': '1069', 'last_page': '1077'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11064', 'display_name': 'Antiplatelet Therapy and Cardiovascular Diseases', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11064', 'display_name': 'Antiplatelet Therapy and Cardiovascular Diseases', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10678', 'display_name': 'Inflammatory mediators and NSAID effects', 'score': 0.9923, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10285', 'display_name': 'Venous Thromboembolism Diagnosis and Management', 'score': 0.987, 'subfield': {'id': 'https://openalex.org/subfields/2724', 'display_name': 'Internal Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cangrelor', 'display_name': 'Cangrelor', 'score': 0.90600514}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.95972925}, {'id': 'https://openalex.org/C2776708134', 'wikidata': 'https://www.wikidata.org/wiki/Q3655338', 'display_name': 'Cangrelor', 'level': 5, 'score': 0.90600514}, {'id': 'https://openalex.org/C177713679', 'wikidata': 'https://www.wikidata.org/wiki/Q679690', 'display_name': 'Intensive care medicine', 'level': 1, 'score': 0.43392527}, {'id': 'https://openalex.org/C2780400711', 'wikidata': 'https://www.wikidata.org/wiki/Q2008344', 'display_name': 'Percutaneous coronary intervention', 'level': 3, 'score': 0.34956682}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.32483205}, {'id': 'https://openalex.org/C500558357', 'wikidata': 'https://www.wikidata.org/wiki/Q12152', 'display_name': 'Myocardial infarction', 'level': 2, 'score': 0.24063009}, {'id': 'https://openalex.org/C2780890252', 'wikidata': 'https://www.wikidata.org/wiki/Q420542', 'display_name': 'Ticagrelor', 'level': 4, 'score': 0.16718838}], 'mesh': [{'descriptor_ui': 'D000249', 'descriptor_name': 'Adenosine Monophosphate', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D010975', 'descriptor_name': 'Platelet Aggregation Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D058919', 'descriptor_name': 'Purinergic P2 Receptor Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D054058', 'descriptor_name': 'Acute Coronary Syndrome', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D054058', 'descriptor_name': 'Acute Coronary Syndrome', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D054058', 'descriptor_name': 'Acute Coronary Syndrome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000249', 'descriptor_name': 'Adenosine Monophosphate', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000249', 'descriptor_name': 'Adenosine Monophosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015906', 'descriptor_name': 'Angioplasty, Balloon, Coronary', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D015906', 'descriptor_name': 'Angioplasty, Balloon, Coronary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002986', 'descriptor_name': 'Clinical Trials as Topic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010975', 'descriptor_name': 'Platelet Aggregation Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058925', 'descriptor_name': 'Receptors, Purinergic P2Y12', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1586/erc.10.90', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S108504264', 'display_name': 'Expert Review of Cardiovascular Therapy', 'issn_l': '1477-9072', 'issn': ['1477-9072', '1744-8344'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20670184', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.83, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 47, 'referenced_works': ['https://openalex.org/W1553345686', 'https://openalex.org/W1866201138', 'https://openalex.org/W1935279647', 'https://openalex.org/W1939515787', 'https://openalex.org/W1966433445', 'https://openalex.org/W1986455514', 'https://openalex.org/W1986775812', 'https://openalex.org/W2001688139', 'https://openalex.org/W2006624707', 'https://openalex.org/W2018383335', 'https://openalex.org/W2020019411', 'https://openalex.org/W2020294937', 'https://openalex.org/W2031081426', 'https://openalex.org/W2032383876', 'https://openalex.org/W2035816283', 'https://openalex.org/W2041686781', 'https://openalex.org/W2043978461', 'https://openalex.org/W2053379248', 'https://openalex.org/W2060258953', 'https://openalex.org/W2071686230', 'https://openalex.org/W2077429173', 'https://openalex.org/W2083038715', 'https://openalex.org/W2095332707', 'https://openalex.org/W2099520328', 'https://openalex.org/W2104599604', 'https://openalex.org/W2107797912', 'https://openalex.org/W2110489891', 'https://openalex.org/W2111440117', 'https://openalex.org/W2121047179', 'https://openalex.org/W2125093797', 'https://openalex.org/W2128350338', 'https://openalex.org/W2131450595', 'https://openalex.org/W2136228924', 'https://openalex.org/W2139891259', 'https://openalex.org/W2140501627', 'https://openalex.org/W2147457754', 'https://openalex.org/W2147615829', 'https://openalex.org/W2163170969', 'https://openalex.org/W2169387542', 'https://openalex.org/W2327850977', 'https://openalex.org/W2329490408', 'https://openalex.org/W2336463032', 'https://openalex.org/W2603192132', 'https://openalex.org/W2887768525', 'https://openalex.org/W3147291885', 'https://openalex.org/W3209376675', 'https://openalex.org/W4205805944'], 'related_works': ['https://openalex.org/W4389568370', 'https://openalex.org/W4281912018', 'https://openalex.org/W3177428554', 'https://openalex.org/W3108674512', 'https://openalex.org/W3032375762', 'https://openalex.org/W3031052312', 'https://openalex.org/W2748952813', 'https://openalex.org/W2560506686', 'https://openalex.org/W2080531066', 'https://openalex.org/W1995515455'], 'abstract_inverted_index': {'Antiplatelet': [0], 'drugs': [1], 'represent': [2], 'the': [3, 26, 50, 83, 126, 138], 'cornerstone': [4], 'of': [5, 31, 52, 62, 82, 97, 137, 141], 'treatment': [6], 'for': [7, 29, 109], 'cardiovascular': [8], 'atherothrombotic': [9], 'disease.': [10], 'Dual': [11], 'oral': [12, 18], 'antiplatelet': [13, 69], 'therapy': [14], 'with': [15, 36, 130], 'aspirin': [16], 'and': [17, 40, 64, 91, 150], 'ADP-receptor': [19], 'antagonists,': [20], 'such': [21, 54], 'as': [22, 55], 'clopidogrel,': [23, 53], 'has': [24], 'been': [25], 'standard': [27], 'choice': [28], 'prevention': [30], 'ischemic': [32], 'events': [33], 'in': [34, 41], 'patients': [35], 'acute': [37], 'coronary': [38, 45], 'syndrome': [39], 'those': [42], 'undergoing': [43], 'percutaneous': [44], 'intervention.': [46], 'However,': [47, 112], 'due': [48], 'to': [49, 120], 'limitations': [51], 'interindividual-response': [56], 'variability,': [57], 'drug–drug': [58], 'interactions,': [59], 'slow': [60], 'onset': [61], 'action': [63], 'irreversible': [65], 'inhibitory': [66], 'effects,': [67], 'novel': [68], 'agents': [70], 'are': [71], 'under': [72], 'clinical': [73, 110, 117, 123, 151], 'development.': [74, 152], 'Cangrelor': [75], 'is': [76, 88], 'a': [77, 106], 'reversible,': [78], 'potent,': [79], 'competitive': [80], 'inhibitor': [81], 'ADP': [84], 'P2Y12': [85], 'receptor': [86], 'that': [87], 'administered': [89], 'intravenously': [90], 'rapidly': [92], 'achieves': [93], 'near': [94], 'complete': [95], 'inhibition': [96], 'ADP-induced': [98], 'platelet': [99], 'aggregation.': [100], 'These': [101], 'pharmacological': [102], 'properties': [103, 149], 'make': [104], 'cangrelor': [105], 'promising': [107], 'drug': [108], 'use.': [111], 'recent': [113], 'large-scale': [114], 'Phase': [115], 'III': [116], 'investigations': [118], 'failed': [119], 'show': [121], 'significant': [122], 'benefit': [124], 'on': [125, 143, 146], 'primary': [127], 'end': [128], 'point': [129], 'cangrelor.': [131], 'This': [132], 'article': [133], 'provides': [134], 'an': [135], 'overview': [136], 'current': [139], 'status': [140], 'knowledge': [142], 'cangrelor,': [144], 'focusing': [145], 'its': [147], 'pharmacologic': [148]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2128314375', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 9}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-09T11:19:45.919022', 'created_date': '2016-06-24'}