Gar1p Binds to the Small Nucleolar RNAs snR10 and snR30 in Vitro through a Nontypical RNA Binding Element

Name: Work Video:
Duration: 3 min 30 s
Claudia Bagni; Bruno Lapeyre
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1037, 1147, 1157, 1333, 1358, 1448, 1455, 1514, 1534, 1553, 1560, 1631, 1640, 1686, 1696, 1735, 1811, 1813, 1875, 1919, 1945, 2002, 2022, 2117, 2147, 2175, 2216, 2240, 2286, 2355, 2582, 2621, 2661, 2689, 2830, 2862, 2954, 2972, 3053, 3132, 3189, 3261, 3269, 3301, 3465, 3512, 3567, 3597, 3611, 3843, 3877, 3915, 3929, 3933, 3956, 3999, 4136, 4191, 4232, 4266, 4286, 4292, 4301, 4343, 4441, 4499, 4522, 4735, 4846, 4855, 4861, 4881, 4984, 4992, 5029, 5032, 5038, 5051, 5059], 'fibrillarin': [5, 40, 48, 72, 86, 248, 283, 291, 315, 329, 1036, 1064, 1087], 'possess': [6, 249], 'a': [7, 53, 115, 176, 227, 250, 296, 358, 419, 470, 743, 772, 883, 1092, 1151, 1432, 1458, 1675, 1729, 1764, 1836, 1903, 2060, 2118, 2124, 2464, 2524, 2531, 2606, 2821, 2855, 2873, 3091, 3136, 3160, 3201, 3293, 3348, 3392, 3430, 3473, 3538, 3638, 3667, 3670, 3759, 3789, 3823, 3872, 3906, 4142, 4241, 4315, 4339, 4377, 4381, 4427, 4435, 4457, 4552, 4563, 4576, 4593, 4626, 4719, 4750, 4800, 4915], 'typical': [8, 251, 1354], 'glycine/arginine-rich': [10, 224, 253, 467, 643], 'domain': [11, 197, 208, 217, 254, 440, 451, 460, 1153, 1165, 1192, 1198, 1231, 1366, 1384, 1434, 2610, 2804, 3203, 4045, 4360, 4459], 'belong': [13, 256, 4977], 'to': [14, 81, 201, 211, 257, 324, 444, 454, 753, 891, 1018, 1039, 1075, 1105, 1161, 1207, 1236, 1373, 1395, 1451, 1456, 1461, 1490, 1500, 1505, 1515, 1549, 1667, 1707, 1720, 1759, 1785, 1966, 1978, 2012, 2052, 2138, 2197, 2202, 2347, 2476, 2487, 2615, 2670, 2787, 2789, 2877, 2902, 2966, 3130, 3180, 3253, 3330, 3387, 3420, 3528, 3537, 3725, 3738, 3904, 3931, 3947, 3962, 4021, 4049, 4140, 4145, 4185, 4188, 4202, 4264, 4284, 4354, 4387, 4422, 4433, 4438, 4442, 4455, 4461, 4490, 4518, 4581, 4718, 4852, 4866, 4872, 4906, 4913, 4967, 4978, 5017, 5044, 5052], 'ribonucleoprotein': [15, 258], 'particles.': [16, 259], 'Both': [17, 260], 'are': [19, 26, 49, 121, 145, 262, 269, 292, 364, 388, 645, 656, 759, 776, 818, 826, 959, 2131, 2145, 2170, 2185, 2584, 2594, 2723, 2763, 2780, 2961, 3050, 3104, 3135, 3145, 3232, 3462, 3469, 3516, 3571, 4108, 4129, 4137, 4182, 4192, 4207, 4233, 5042], 'essential': [20, 123, 263, 366, 3374, 4194, 4836, 4868], 'for': [21, 28, 43, 130, 147, 152, 264, 271, 286, 373, 390, 395, 761, 828, 894, 1621, 1638, 1928, 1950, 2126, 2206, 2511, 2667, 2767, 2820, 2912, 3023, 3094, 3113, 3244, 3339, 3375, 3479, 3607, 3620, 3637, 3666, 4132, 4195, 4536, 4592, 4616, 4667, 4703, 4828, 4834, 4869, 5024, 5035, 5047, 5056], 'yeast': [22, 125, 265, 368, 1608, 1862, 3393, 4341], 'cell': [23, 149, 266, 392, 1453, 3394, 3837, 3855, 4134, 4428, 4520, 4669, 4733, 4769, 4810], 'growth': [24, 150, 267, 393, 1454, 3390, 4135, 4425, 4521], 'required': [27, 42, 146, 210, 270, 285, 389, 453, 760, 827, 893, 2766, 4139, 4535, 4827], 'pre-rRNA': [29, 37, 44, 135, 153, 272, 280, 287, 378, 396, 582, 663, 762, 833, 896, 967, 3870, 4116], 'processing.': [30, 273, 763, 4117], 'In': [31, 137, 274, 380, 2258, 2770, 3128, 3214, 3548, 4170], 'addition,': [32, 275, 3549], 'is': [34, 41, 63, 73, 182, 209, 237, 277, 284, 306, 316, 425, 452, 480, 579, 742, 902, 946, 1065, 1193, 1360, 1385, 1449, 1547, 2111, 2158, 2179, 2204, 2220, 2365, 2485, 2504, 2516, 2521, 2737, 2750, 3033, 3040, 3081, 3090, 3117, 3123, 3195, 3250, 3355, 3361, 3373, 3456, 3509, 3561, 3797, 3902, 3938, 3943, 3992, 4013, 4035, 4100, 4256, 4295, 4348, 4420, 4453, 4488, 4516, 4534, 4653, 4665, 4711, 4773, 4795, 4825, 4864, 4886, 4889], 'involved': [35, 278, 580, 657, 755, 961, 1210, 2601, 4114, 4731], 'in': [36, 124, 161, 189, 279, 367, 404, 432, 498, 581, 658, 756, 962, 1155, 1200, 1211, 1241, 1551, 1568, 1601, 1748, 1780, 1794, 1835, 1886, 1931, 1975, 2107, 2366, 2438, 2460, 2596, 2602, 2828, 2838, 2859, 2964, 3099, 3107, 3151, 3208, 3247, 3363, 3423, 3518, 3574, 3706, 3708, 3741, 3750, 3835, 3838, 3853, 3935, 3945, 4052, 4110, 4115, 4228, 4235, 4250, 4352, 4447, 4482, 4485, 4525, 4540, 4558, 4572, 4595, 4660, 4721, 4732, 4752, 4786, 4807, 4884, 4894, 4998, 5054], 'pseudouridylation,': [38, 281], 'whereas': [39, 71, 282, 314, 933, 1228, 3088, 3467], 'methylation.': [45, 288], 'each': [50, 293, 1409, 2512, 3865], 'associated': [51, 109, 294, 352, 646, 819, 1066, 1107, 2376, 2522, 4208, 4468, 4908], 'with': [52, 65, 75, 110, 166, 295, 308, 318, 353, 409, 647, 667, 820, 1029, 1067, 1108, 1368, 1398, 1443, 1555, 1611, 1692, 1830, 1913, 1961, 1968, 2015, 2055, 2113, 2135, 2224, 2260, 2368, 2377, 2433, 2493, 2523, 2618, 2649, 2772, 3256, 3472, 3615, 3864, 3868, 4006, 4088, 4209, 4313, 4338, 4344, 4469, 4625, 4821, 4896, 4909], 'different': [54, 241, 297, 484, 1522, 1664, 3038, 3075, 3715, 4695], 'subset': [55, 298, 744, 885], 'of': [56, 69, 118, 172, 192, 222, 230, 233, 299, 312, 361, 415, 435, 465, 473, 476, 501, 572, 603, 654, 745, 765, 769, 900, 1021, 1091, 1190, 1232, 1249, 1352, 1381, 1411, 1419, 1424, 1429, 1435, 1509, 1528, 1537, 1698, 1751, 1767, 1792, 1797, 1820, 1825, 1833, 1839, 1842, 1861, 1872, 1878, 1916, 1934, 1981, 2121, 2154, 2194, 2211, 2244, 2251, 2441, 2444, 2474, 2491, 2500, 2527, 2579, 2589, 2645, 2655, 2657, 2682, 2693, 2801, 2813, 2823, 2872, 2905, 2957, 3020, 3029, 3046, 3061, 3066, 3096, 3110, 3138, 3162, 3200, 3296, 3378, 3391, 3434, 3445, 3453, 3506, 3540, 3558, 3581, 3585, 3594, 3624, 3641, 3673, 3700, 3703, 3753, 3758, 3763, 3792, 3827, 3829, 3875, 3909, 3912, 3916, 4042, 4085, 4096, 4103, 4127, 4244, 4247, 4269, 4318, 4426, 4478, 4505, 4551, 4562, 4575, 4629, 4728, 4743, 4764, 4780, 4802, 4898, 4920, 4981, 5004, 5011, 5014], 'the': [57, 66, 76, 97, 106, 134, 139, 190, 193, 202, 223, 231, 234, 300, 309, 319, 340, 349, 377, 382, 433, 436, 445, 466, 474, 477, 492, 499, 568, 573, 604, 648, 662, 746, 766, 778, 821, 832, 876, 934, 966, 1022, 1041, 1098, 1163, 1201, 1229, 1247, 1250, 1353, 1364, 1379, 1382, 1412, 1420, 1425, 1462, 1498, 1502, 1507, 1510, 1518, 1526, 1529, 1556, 1635, 1669, 1699, 1721, 1746, 1749, 1786, 1795, 1887, 1898, 1920, 1956, 1962, 1969, 2016, 2056, 2142, 2155, 2167, 2192, 2195, 2198, 2212, 2217, 2225, 2245, 2249, 2252, 2261, 2348, 2369, 2378, 2422, 2439, 2472, 2477, 2489, 2494, 2498, 2576, 2585, 2642, 2650, 2662, 2668, 2672, 2679, 2683, 2691, 2694, 2733, 2740, 2751, 2757, 2768, 2773, 2777, 2790, 2795, 2802, 2807, 2834, 2869, 2903, 2967, 3021, 3024, 3036, 3057, 3074, 3079, 3085, 3097, 3111, 3120, 3141, 3153, 3178, 3198, 3210, 3221, 3228, 3237, 3257, 3264, 3277, 3283, 3288, 3336, 3340, 3356, 3364, 3376, 3379, 3382, 3389, 3435, 3438, 3442, 3451, 3476, 3502, 3522, 3531, 3541, 3544, 3556, 3575, 3579, 3582, 3590, 3608, 3616, 3698, 3701, 3704, 3709, 3742, 3756, 3836, 3854, 3869, 3897, 3910, 3913, 3917, 3948, 3952, 3957, 3994, 4039, 4043, 4083, 4086, 4097, 4101, 4123, 4133, 4146, 4178, 4189, 4196, 4203, 4218, 4221, 4230, 4245, 4248, 4270, 4319, 4393, 4424, 4430, 4439, 4445, 4470, 4537, 4549, 4560, 4573, 4617, 4668, 4699, 4704, 4707, 4726, 4744, 4762, 4765, 4777, 4781, 4790, 4803, 4815, 4835, 4841, 4844, 4847, 4853, 4857, 4862, 4870, 4877, 4882, 4899, 4910, 4979, 4982, 4990, 5009, 5012, 5015, 5025], 'small': [58, 301, 494, 620, 624, 630, 2018, 3840], 'RNAs': [60, 204, 303, 447, 496, 958, 1741, 2020, 3712, 4991], '(snoRNAs).': [61, 304], 'co-immunoprecipitated': [64, 74, 307, 317, 2014], 'H/ACA': [67, 98, 107, 310, 341, 350, 779, 877, 936, 1110], 'family': [68, 311], 'snoRNAs,': [70, 313, 619, 878, 1071, 1558, 2057, 2496], 'C/D': [77, 320, 747, 1070], 'family.': [78, 321], 'However,': [79, 195, 322, 438, 740, 2842, 3191, 3347, 3619, 4118, 4514], 'attempts': [80, 323, 1074], 'demonstrate': [82, 325], 'direct': [83, 326, 1077, 1134, 4741], 'interactions': [84, 93, 327, 336, 1078, 1530, 3878, 3918], 'between': [85, 94, 240, 328, 337, 483, 1520, 1532, 2214, 3073, 3084, 3282, 3919, 3954, 3997, 4859, 4879], 'snoRNAs': [88, 99, 108, 119, 141, 331, 342, 351, 362, 384, 614, 748, 770, 780, 937, 2219, 2350, 2528, 2742, 2791, 3259, 3705, 3830, 4190, 4446, 4845, 4863, 4883], 'have': [89, 332, 888, 1079, 2686, 2844, 4046, 4224, 4476, 4903], 'failed,': [90, 333], 'such': [92, 335], 'had': [100, 343, 1496, 2008], 'not': [101, 122, 344, 365, 751, 951, 1080, 1392, 2764, 2781, 2852, 2867, 3343, 3535, 3632, 3798, 4130, 4138, 4183, 4193, 4304, 4475, 4965, 4976], 'yet': [102, 345, 952, 1137, 3344], 'been': [103, 346, 489, 889, 1016, 1061, 1081, 1103, 1138, 1393, 2010, 2256, 2687, 3299, 3345, 4047, 4611, 4759, 4904], 'reported.': [104, 347, 1139], 'Among': [105, 348, 875], 'Gar1p,': [111, 354, 1140, 3240, 3793, 4839], 'one': [112, 221, 355, 464, 565, 1407], 'can': [113, 218, 356, 461, 504, 938, 3206, 3242, 3832, 4545, 4566], 'distinguish': [114, 357], 'large': [116, 359, 2119, 3464, 3825, 3844], 'group': [117, 360], 'that': [120, 158, 175, 236, 363, 401, 418, 479, 491, 578, 749, 1034, 1063, 1086, 1363, 1414, 1439, 1545, 2191, 2371, 2506, 2519, 2529, 2685, 2731, 2756, 2832, 2847, 2863, 2975, 3119, 3144, 3158, 3279, 3328, 3360, 3370, 3450, 3530, 3552, 3749, 3831, 3849, 3860, 3925, 3940, 3951, 3993, 4014, 4030, 4122, 4177, 4199, 4220, 4297, 4492, 4532, 4557, 4613, 4655, 4713, 4724, 4761, 4785, 4799, 4814, 4843, 4856, 4891, 4902, 4973, 4985], 'serve': [127, 370], 'as': [128, 371, 1141, 1143, 1162, 1626, 1769, 1987, 2123, 2419, 2792, 2854, 3441, 3613, 3634, 3729, 3856, 4274, 4276, 4831, 4833], 'guides': [129, 372], 'pseudouridine': [131, 374], 'synthesis': [132, 375, 3623, 4723], 'onto': [133, 376, 661, 831, 965, 1009], 'molecule.': [136, 379], 'contrast,': [138, 381, 3215], 'two': [140, 168, 383, 411, 508, 957, 1404, 1426, 1557, 2017, 2218, 2226, 2349, 2495, 2571, 2577, 2651, 2734, 2955, 3229, 3258, 3284, 4104, 4124, 4179, 4251, 4471, 4694], 'snR10': [142, 385, 879, 1559, 1639, 2021, 2163, 2435, 3182, 3260, 3726, 3734, 3932], 'snR30': [144, 387, 881, 901, 2023, 2165, 2380, 2446, 3184, 3262, 3728, 3736, 3934, 3959, 4911], 'normal': [148, 391, 895], 'cleavage.': [154, 397], 'We': [155, 398, 2638, 3520, 3922, 4527, 5020, 5041], 'show': [156, 399, 1076], 'here': [157, 400, 3924], 'interacts': [160, 403, 4893], 'vitro': [162, 405, 3255, 3424, 4032, 4448, 4483, 4885], 'directly': [163, 406, 1096, 1209, 1397, 2054, 2617, 3928], 'specifically': [165, 408, 1554, 3930, 4187, 4443], 'these': [167, 410, 956, 1369, 1538, 2501, 3454, 3507, 3559, 4215, 4384, 4479, 4530, 5005], 'snoRNAs.': [169, 412, 1099, 1503, 2652], 'Deletion': [170, 413, 1423, 4237], 'analysis': [171, 414, 1527, 4174, 4238], 'indicates': [174, 417], 'major': [177, 420, 4252, 4378, 4816], 'RNA': [178, 421, 575, 1011, 1212, 1242, 1251, 1355, 1370, 1445, 1715, 1725, 1761, 1834, 1958, 1964, 1984, 2116, 2168, 2183, 2196, 2228, 2513, 2603, 2623, 3211, 3289, 3422, 4001, 4211, 4231, 4322, 4356, 4510, 4538, 4605, 4619, 4817], 'binding': [179, 422, 1213, 1446, 1821, 1843, 1873, 1917, 2193, 2267, 2291, 2346, 2357, 2473, 3179, 3212, 3222, 3290, 3942, 4197, 4204, 4212, 4229, 4357, 4511, 4539, 4818], 'element,': [180, 423], 'which': [181, 424, 1633, 2265, 2289, 2798, 3241, 3335, 4007, 4107, 4495, 4824], 'extremely': [183, 426], 'well': [184, 427, 1142, 3147, 4275, 4367, 4832], 'conserved': [185, 239, 428, 482, 3150, 4290, 4368], 'throughout': [186, 429, 3140], 'evolution,': [187, 430], 'lies': [188, 431], 'middle': [191, 434], 'protein.': [194, 437, 1422, 1971, 2591, 3380], 'this': [196, 439, 668, 1191, 1389, 1493, 1569, 2590, 2848, 3108, 3114, 3371, 3941, 4171, 4359, 4543, 4599], 'alone': [198, 441, 4016, 4466], 'binds': [199, 442, 3927, 4017], 'poorly': [200, 443], 'target': [203, 446, 1457, 4002, 4090, 4141], 'an': [206, 449, 1238, 1979, 3064, 4225, 4614, 4714, 4796, 4808], 'accessory': [207, 216, 450, 459, 1239, 4226], 'restore': [212, 455], 'efficient': [213, 456], 'binding.': [214, 457], 'be': [219, 462, 505, 754, 892, 939, 1019, 1089, 1106, 1208, 2013, 3739, 3833, 4022, 4050, 4546, 4568, 4602, 4850, 4867, 4907], 'either': [220, 463, 2162, 2421, 3146, 3181, 4456, 4481], 'domains': [225, 468, 1428, 2573, 2593, 2644, 2759, 2779, 3231, 4126, 4181, 4223], 'or': [226, 469, 950, 1008, 1605, 1614, 2164, 2235, 2425, 3148, 3183, 3665, 3727, 3787, 3859, 4460, 4467, 4484, 4838], 'second': [228, 471, 767], 'element': [229, 472, 4819], 'core': [232, 475, 3143, 4246, 4980], 'protein': [235, 478, 650, 823, 1204, 1390, 1460, 1512, 2105, 2430, 2753, 2875, 4005, 4028, 4034, 4087, 4144, 4249, 4316, 4437, 4848], 'highly': [238, 481, 4271, 4289], 'species.': [242, 485, 3076], 'It': [486, 945, 1058, 2503, 3937, 4294, 4347, 4487, 4555, 4652, 4710, 4757, 4794], 'has': [487, 1014, 1059, 1101, 1136, 1391, 1403, 1440, 2255, 2455, 3298, 3325, 3342, 4175, 4239, 4507, 4609, 4758], 'recently': [488, 1102, 4610], 'demonstrated': [490, 1062, 2221], 'numerous': [493], 'found': [497, 890, 1199, 2837, 3551], 'nucleolus': [500, 1463, 3821, 4147, 4766, 4804, 4854], 'eukaryotic': [502], 'cells': [503, 1598, 3455, 3477, 3508, 3515, 3524, 3560, 3566, 3570, 4705], 'sorted': [506], 'into': [507, 1681], 'classes': [509], '(1Balakin': [510, 670, 781, 1112, 2534], 'A.G.': [511, 671, 782, 1113, 2535], 'Smith': [512, 672, 783, 1114, 2536], 'L.': [513, 673, 784, 1115, 1253, 1273, 2537, 2930], 'Fournier': [514, 674, 700, 785, 859, 992, 1116, 2538, 3881], 'M.J.': [515, 675, 701, 786, 860, 993, 1117, 2327, 2539, 3882], 'Cell.': [516, 534, 554, 676, 726, 787, 841, 861, 923, 974, 994, 1118, 1323, 1653, 2540, 3489, 4642], '1996;': [517, 677, 727, 788, 1119, 2541], '86:': [518, 678, 789, 1120, 2542], '823-834Abstract': [519, 679, 790, 1121, 2543], 'Full': [520, 522, 538, 540, 594, 680, 682, 708, 730, 732, 791, 793, 845, 847, 865, 867, 978, 980, 998, 1000, 1122, 1124, 1266, 1480, 2312, 2400, 2402, 2544, 2546, 2715, 2895, 3411, 3493, 3980, 3982, 4073, 4164, 4412, 4686], 'Text': [521, 523, 539, 541, 595, 681, 683, 709, 731, 733, 792, 794, 846, 848, 866, 868, 979, 981, 999, 1001, 1123, 1125, 1267, 1481, 2313, 2401, 2403, 2545, 2547, 2716, 2896, 3412, 3494, 3981, 3983, 4074, 4165, 4413, 4687], 'PDF': [524, 542, 596, 684, 710, 734, 795, 849, 869, 982, 1002, 1126, 1268, 1482, 2314, 2404, 2548, 2717, 2897, 3413, 3495, 3984, 4075, 4166, 4414, 4688], 'PubMed': [525, 543, 559, 597, 685, 711, 735, 796, 812, 850, 870, 913, 928, 983, 1003, 1053, 1127, 1183, 1223, 1269, 1288, 1306, 1328, 1345, 1483, 1591, 1658, 1997, 2041, 2082, 2098, 2281, 2315, 2338, 2405, 2549, 2565, 2633, 2718, 2898, 2949, 2996, 3013, 3318, 3414, 3496, 3660, 3690, 3782, 3815, 3889, 3985, 4076, 4167, 4333, 4415, 4647, 4689, 4939, 4959], 'Scopus': [526, 544, 560, 598, 686, 712, 736, 797, 813, 851, 871, 914, 929, 984, 1004, 1054, 1128, 1184, 1224, 1289, 1307, 1329, 1346, 1592, 1659, 1998, 2042, 2083, 2099, 2282, 2339, 2406, 2550, 2566, 2634, 2950, 2997, 3014, 3319, 3497, 3661, 3691, 3783, 3816, 3890, 3986, 4334, 4648, 4940, 4960], '(387)': [527, 687, 798, 1129, 2551], 'Google': [528, 546, 562, 600, 688, 714, 738, 799, 815, 853, 873, 916, 931, 986, 1006, 1056, 1130, 1186, 1226, 1270, 1291, 1309, 1331, 1348, 1484, 1594, 1661, 2000, 2044, 2085, 2101, 2284, 2316, 2341, 2408, 2552, 2568, 2636, 2719, 2899, 2952, 2999, 3016, 3321, 3415, 3499, 3663, 3693, 3785, 3818, 3892, 3988, 4077, 4168, 4336, 4416, 4650, 4690, 4942, 4962], 'Scholar,': [529, 547, 689, 715, 800, 854, 917, 987, 1271, 2086, 2317, 2553, 3000, 4943], '2Smith': [530], 'C.M.': [531], 'Steitz': [532, 1046], 'J.A.': [533, 1047], '1997;': [535, 556, 809, 842, 862, 975, 995, 2562, 3315, 3687, 3812, 4644, 4956], '89:': [536, 843, 863, 976, 996], '669-672Abstract': [537], '(284)': [545], '3Tollervey': [548], 'D.': [549, 587, 905, 921, 1175, 1338, 1583, 1646, 1651, 1991, 2033, 2065, 2988, 3652, 3774, 4640, 4931, 5033], 'Kiss': [550, 724, 805, 839, 972, 2558, 3311, 3683, 3808, 4952], 'T.': [551, 725, 806, 840, 973, 1299, 2559, 3312, 3684, 3809, 4953], 'Curr.': [552], 'Opin.': [553], 'Biol.': [555, 924, 1261, 1302, 1324, 1341, 1475, 1654, 2307, 2395, 2710, 2890, 3406, 3975, 4068, 4159, 4407, 4643, 4681], '9:': [557], '337-342Crossref': [558], '(388)': [561], 'Scholar)': [563, 1007, 1349, 2001, 2285, 2409, 2720, 3416, 3664, 4337], 'if': [564], 'sets': [566], 'apart': [567], 'unique': [569], 'RNA,': [570], 'component': [571, 4317], 'mitochondrial': [574, 4321], 'processing': [576, 583, 3898, 4323], 'RNase': [577, 4320], '(4Morrissey': [584], 'J.P.': [585, 691, 721, 919, 1465, 1649, 2700, 2880, 3396, 4149, 4397, 4636, 4671], 'Tollervey': [586, 920, 1174, 1337, 1582, 1647, 1650, 2032, 2987, 3651, 3773, 4639, 4930, 5034], 'Trends': [588, 702], 'Biochem.': [589, 703, 1284, 3885], 'Sci.': [590, 704], '1995;': [591, 705, 2397, 3886, 3977], '20:': [592, 706], '78-82Abstract': [593], '(113)': [599], 'Scholar).': [601, 739, 816, 874, 1057, 1187, 1292, 1485, 1595, 1662, 2045, 2102, 2569, 2637, 2900, 3017, 3322, 3500, 3694, 3819, 3893, 3989, 4078, 4169, 4417, 4651, 4691], 'Members': [602, 764], 'first': [605], 'class': [606, 768], 'contain': [607, 771, 1032, 1150, 1350, 1634, 4305], 'structural': [608], 'motifs': [609, 1372, 1447], 'called': [610, 777], 'box': [611, 1069, 3098], 'C/D.': [612], 'These': [613, 1083, 2592], '1The': [615], 'abbreviations': [616], 'used': [617, 1567, 1666, 1706, 2059, 2186], 'are:': [618], 'RNAs;': [622], 'snRNA,': [623], 'nuclear': [625, 635, 2840, 2856], 'RNA;': [626], 'RNP,': [627], 'ribonucleoprotein;': [628], 'snoRNP,': [629], 'RNP;': [632, 636], 'hnRNP,': [633], 'heterogeneous': [634, 3517], 'PAGE,': [637], 'polyacrylamide': [638], 'gel': [639], 'electrophoresis;': [640], 'GAR': [641, 1164, 1230, 1365, 1383, 1405, 1427, 2572, 2643, 2735, 2758, 2778, 2808, 3202, 3230, 4044, 4105, 4125, 4180, 4222, 4458, 4472, 4553, 4577, 4588], 'domain,': [642, 4578], 'domain.': [644, 4213, 4554], 'fibrillarin,': [651, 1378], 'most': [653, 2586, 2680, 4093], 'them': [655, 4994], 'targeting': [659, 829, 963, 2857, 4524, 4830], 'methylation': [660], 'through': [664], 'base': [665, 1610], 'pairing': [666], 'molecule': [669, 834], '5Bachellerie': [690], 'Michot': [692], 'B.': [693, 1177, 1473, 1585, 1687, 2035, 2387, 2391, 2708, 2888, 2990, 3006, 3270, 3404, 3654, 3776, 3967, 3971, 4056, 4157, 4405, 4679, 4709, 4933], 'Nicoloso': [694], 'M.': [695, 804, 1171, 1215, 1259, 1281, 1317, 1469, 1579, 2029, 2090, 2273, 2557, 2625, 2704, 2884, 2938, 2984, 3004, 3310, 3400, 3648, 3682, 3770, 3807, 4153, 4401, 4638, 4675, 4927, 4951], 'Balakin': [696], 'A.': [697, 1275, 1319, 3100], 'Ni': [698], 'J.': [699, 856, 909, 989, 1049, 1167, 1179, 1219, 1260, 1283, 1300, 1339, 1474, 1575, 1587, 1993, 2025, 2037, 2070, 2074, 2078, 2088, 2094, 2277, 2306, 2394, 2629, 2709, 2889, 2932, 2980, 2992, 3002, 3314, 3405, 3644, 3656, 3686, 3766, 3778, 3811, 3974, 4067, 4158, 4406, 4632, 4680, 4923, 4935, 4955], '261-264Abstract': [707], '(144)': [713], '6Kiss-Laszlo': [716], 'Z.': [717], 'Henry': [718, 3305, 3677, 3802, 4946], 'Y.': [719, 3306, 3678, 3803, 4947], 'Bachellerie': [720], 'Caizergues': [722], 'F.M.': [723], '85:': [728], '1077-1088Abstract': [729], '(677)': [737], 'there': [741, 3089, 3103, 3134], 'do': [750, 4303], 'appear': [752, 3737], 'methylation,': [757], 'but': [758, 1132, 2463, 2762, 2805, 4020, 4198, 4449, 4501, 4542], '"hairpin-hinge-hairpin-tail"': [773], 'structure': [774, 1508, 2533, 5013], '7Ganot': [801, 2554], 'P.': [802, 836, 969, 1684, 2389, 2555, 2924, 3969], 'Caizergues-Ferrer': [803, 1170, 1468, 1578, 2028, 2556, 2703, 2883, 2983, 3003, 3309, 3399, 3647, 3681, 3769, 3806, 4152, 4400, 4637, 4674, 4926, 4950], 'Genes': [807, 2560, 4328], 'Dev.': [808, 2561, 4329], '11:': [810, 1181, 1221, 1589, 2039, 2279, 2563, 2631, 2994, 3658, 3780, 4937], '941-956Crossref': [811, 2564], '(285)': [814, 2567], 'They': [817], 'pseudouridylation': [830, 964], '(8Ganot': [835, 968], 'Bortolin': [837, 970], 'M.L.': [838, 971], '799-809Abstract': [844, 977], '(509)': [852, 985], '9Ni': [855, 988], 'Tien': [857, 990], 'A.L.': [858, 991], '565-573Abstract': [864, 997], '(435)': [872, 1005], 'form': [882], 'separate': [884, 2509], 'since': [886, 1025, 1388, 2514, 4380, 4607, 4662, 4771], 'they': [887, 2722, 3861, 4200, 4206], 'processing,': [897], 'deletion': [899, 2865, 3157, 3217, 3383, 3621, 4173, 4382, 4664], 'lethal': [903, 4624, 4666], '(10Tollervey': [904], 'Guthrie': [906], 'C.': [907, 1467, 2702, 2882, 2942, 3304, 3398, 3676, 3801, 4151, 4399, 4634, 4673, 4945], 'EMBO': [908, 1048, 1178, 1218, 1586, 1992, 2036, 2077, 2093, 2276, 2628, 2991, 3313, 3655, 3685, 3777, 3810, 4934, 4954], '1985;': [910], '4:': [911], '3873-3878Crossref': [912], '(51)': [915, 2407, 3987], '11Morrissey': [918], 'Mol.': [922, 1322, 1652, 4641], '1993;': [925, 1655, 3010], '13:': [926, 1656], '2469-2477Crossref': [927, 1657], '(191)': [930, 1660], 'Scholar),': [932, 1131, 1227, 1310, 1332, 2342, 2953, 3786, 4963], 'other': [935, 1010, 1535, 2423, 2598, 3866, 4582, 4586, 4658, 4900, 4986], 'deleted': [940, 1670], 'without': [941, 1095, 1817], 'any': [942, 1399, 3216, 4306, 4477], 'significant': [943, 3092], 'phenotype.': [944], 'still': [947, 1194, 2375], 'controversial': [948], '(snR10)': [949], 'determined': [953, 1770], '(snR30)': [954], 'whether': [955, 1492, 2048, 2641], 'also': [960, 3082, 3170, 3251, 4362, 4375, 4567, 4826], 'molecules.': [1012, 2208], 'Fibrillarin': [1013], 'long': [1015], 'known': [1017, 1444, 2518], 'part': [1020, 1090, 2800, 3209], 'snoRNP': [1023, 3958], 'particles,': [1024, 2140, 3847], 'antisera': [1026], 'from': [1027, 1674, 2232, 2969, 3035, 3263, 3334, 3714, 4261, 4281, 4372, 4529, 4749, 4995], 'humans': [1028], 'autoimmune': [1030], 'diseases': [1031], 'antibodies': [1033], 'recognize': [1035], 'allow': [1038, 5008], 'precipitate': [1040], 'snoRNA': [1042, 1111, 3794, 4968], 'U3': [1043], '(12Tyc': [1044], 'K.': [1045, 2926], '1989;': [1050, 2079], '8:': [1051, 2080, 4331], '3113-3119Crossref': [1052], '(327)': [1055], 'now': [1060, 2517, 2962], 'all': [1068, 1149, 3152], 'even': [1072, 3124, 3192, 3226, 3568, 4571], 'though': [1073], 'successful.': [1082], 'observations': [1084, 4216], 'suggest': [1085], 'could': [1088, 2647, 3851, 3862, 4009, 4081, 4601, 4697, 4747, 4805, 4849], 'larger': [1093], 'structure,': [1094], 'contacting': [1097], 'shown': [1104, 1235, 1394, 2011, 2846, 4048, 4612], 'every': [1109], 'no': [1133, 1441, 2356, 2816], 'interaction': [1135, 2213, 2490, 3996, 4084, 4878], 'Nop1p/fibrillarin,': [1144], 'Nsr1p/nucleolin/gar2p,': [1145], 'Ssb1p,': [1146], 'Nop3p': [1148, 1334], 'similar': [1152, 1765], 'rich': [1154, 2827], 'glycine': [1156], 'arginine': [1158, 4040], 'residues': [1159, 1438, 3139, 4041, 4258, 4262, 4282, 4291, 4369, 4385, 4504], 'referred': [1160], '(13Girard': [1166, 1574, 2024, 2979, 3643, 3765, 4922], 'Lehtonen': [1168, 1576, 2026, 2981, 3645, 3767, 4924], 'H.': [1169, 1577, 2027, 2928, 2982, 3646, 3768, 4925], 'Amalric': [1172, 1256, 1278, 1470, 1580, 2030, 2705, 2885, 2985, 3401, 3649, 3771, 4057, 4154, 4402, 4676, 4928, 5046], 'F.': [1173, 1257, 1279, 1471, 1581, 2031, 2297, 2706, 2886, 2986, 3402, 3650, 3772, 4058, 4155, 4403, 4677, 4929, 5045], 'Lapeyre': [1176, 1472, 1584, 2034, 2707, 2887, 2989, 3005, 3403, 3653, 3775, 4156, 4404, 4678, 4932], '1992;': [1180, 1220, 1263, 1285, 1342, 1588, 2038, 2278, 2630, 2993, 3490, 3657, 3779, 4936], '673-682Crossref': [1182, 1590, 2040, 2995, 3659, 3781, 4938], '(226)': [1185, 1593, 2043, 2998, 3662, 3784, 4941], 'function': [1189, 3377, 4600], 'hypothetical.': [1195], 'A': [1196, 2480, 2653, 2676, 2727, 3156, 3610, 4739], 'related': [1197, 2608], 'hnRNP': [1202, 2262, 2287, 2774], 'U': [1203, 2263, 2775], 'was': [1205, 1234, 1571, 1717, 1726, 1828, 1909, 1940, 1959, 1985, 2050, 2374, 2431, 2613, 3385, 3425, 3534, 3605, 3628, 3960, 4622], 'suggested': [1206], '(14Kiledjian': [1214, 2272, 2624], 'Dreyfuss': [1216, 2274, 2626], 'G.': [1217, 1255, 1277, 2275, 2627], '2655-2664Crossref': [1222, 2280, 2632], '(529)': [1225, 2283, 2635], 'nucleolin': [1233, 4054], 'play': [1237, 4376], 'role': [1240, 1380, 4227, 4379], 'binding,': [1243], 'possibly': [1244], 'by': [1245, 1645, 1744, 1771, 1942, 2004, 2133, 2149, 2161, 2222, 2739, 2794, 3525, 3719, 3755, 4548, 4604], 'changing': [1246], 'conformation': [1248], '(15Ghisolfi': [1252], 'Joseph': [1254, 1276], 'Erard': [1258, 1280], 'Chem.': [1262, 1476, 2308, 2396, 2711, 2891, 3407, 3976, 4069, 4160, 4408, 4682], '267:': [1264], '2955-2959Abstract': [1265], '16Ghisolfi': [1272], 'Kharrat': [1274], 'Eur.': [1282], '209:': [1286], '541-548Crossref': [1287], '(103)': [1290], 'Nsr1p': [1293], '(17Lee': [1294], 'W.C.': [1295], 'Xue': [1296], 'Z.X.': [1297], 'Mélèse': [1298], 'Cell': [1301, 1340], '1991;': [1303, 2335], '113:': [1304], '1-12Crossref': [1305], '(150)': [1308], 'Ssb1p': [1311], '(18Jong': [1312], 'A.Y.': [1313], 'Clark': [1314], 'M.W.': [1315], 'Gilbert': [1316], 'Oehm': [1318], 'Campbell': [1320], 'J.L.': [1321], '1987;': [1325, 1994, 2095], '7:': [1326], '2947-2955Crossref': [1327], '(90)': [1330], '(19Russell': [1335], 'I.D.': [1336], '119:': [1343], '737-747Crossref': [1344], '(88)': [1347], 'copies': [1351], 'recognition': [1356, 1371], 'motif,': [1357], 'it': [1359, 2515, 3032, 3116, 3901, 4025, 4452, 4515, 4608, 4772, 4888], 'therefore': [1361, 2639], 'conceivable': [1362, 4712, 4890], 'cooperates': [1367], 'enhance': [1374], 'their': [1375, 1521, 3920, 5057], 'function.': [1376, 4756, 4875], 'For': [1377, 1953, 3055, 3077, 4037, 4584], 'less': [1386, 2747], 'obvious': [1387], 'interact': [1396, 1550, 2053, 2616, 2648], 'RNA.': [1400, 2427, 2479, 4091], 'Curiously,': [1401], 'domains,': [1406, 2736, 4106, 4473], 'at': [1408, 1808, 1867, 1895, 1925, 2268, 2292, 2351, 2358, 2382, 2575, 3350, 3553], 'end': [1410], 'protein,': [1413, 2264, 2776], 'together': [1415], 'represent': [1416], 'almost': [1417, 2469, 3175], '40%': [1418], 'total': [1421, 1837], 'leaves': [1431], 'central': [1433, 2803, 2811, 3025], 'only': [1436, 3357, 4450], '104': [1437], 'similarity': [1442], 'sufficient': [1450, 2782, 3386, 4184, 4517], 'support': [1452, 3388, 4217, 4519, 5050], 'fusion': [1459], '(20Girard': [1464, 2699, 2879, 3395, 4148, 4396, 4670], 'Bagni': [1466, 2701, 2881, 3268, 3397, 4150, 4398, 4672], '1994;': [1477, 2712, 2892, 2946, 3408, 4161, 4330, 4409, 4683], '269:': [1478, 2713, 2893, 3409, 4162, 4410, 4684], '18499-18506Abstract': [1479, 2714, 2894, 3410, 4163, 4411, 4685], 'This': [1486, 2364, 3274, 3323, 3745, 4079, 4970], 'result': [1487, 3275, 4748, 4806, 4971], 'prompted': [1488], 'us': [1489], 'investigate': [1491], 'short': [1494], 'peptide': [1495], 'retained': [1497, 2738], 'ability': [1499, 2669, 3419], 'bind': [1501, 2671, 2788, 3421, 4186, 4444, 4989], 'Therefore,': [1504], 'decipher': [1506], 'snoRNA-nucleolar': [1511], 'complexes': [1513, 2130], 'better': [1516, 3907], 'understand': [1517, 3895], 'relationship': [1519], 'components,': [1523], 'we': [1524, 2058, 2413, 2843, 2976, 3428, 3550, 3696, 4119], 'undertook': [1525, 3429], 'existing': [1531], 'members': [1536], 'complexes.': [1539], 'present': [1541, 2459, 2530, 2595, 3233, 3834, 4109], 'study': [1542, 1570], 'provides': [1543], 'evidence': [1544], 'able': [1548, 2051, 3252, 4421], 'vitrodirectly': [1552], 'snR30.': [1561], 'Saccharomyces': [1563], 'cerevisiae': [1564, 1597, 2234, 2861, 2971], 'haploid': [1565], 'strain': [1566, 3436, 3639, 3668], 'described': [1572, 1988, 2062, 3302], 'previously': [1573, 1884, 1989, 2009, 2061, 2697, 2845, 3635, 4120], 'S.': [1596, 2233, 2860, 2936, 2970, 3238, 3248], 'were': [1599, 1624, 1642, 1672, 1705, 1742, 1757, 1778, 1806, 1890, 1900, 1923, 1973, 2659, 2665, 3601, 3717], 'grown': [1600, 1974], 'minimal': [1602], 'medium': [1603, 1977], '(SGal': [1604], 'SGlu:': [1606], '0.67%': [1607], 'nitrogen': [1609, 3480], '2%': [1612], 'glucose': [1613], 'galactose)': [1615], 'plus': [1616], 'appropriate': [1617, 1700], 'nutrients.': [1618], 'Standard': [1619], 'procedures': [1620], 'handling': [1622], 'yeasts': [1623, 3086], 'essentially': [1625], 'described.': [1627], 'plasmids': [1629, 5031], 'pT3/T7a18:10': [1630], 'pT3/T7a18:30,': [1632], 'genes': [1636], 'coding': [1637], 'snR30,': [1641], 'kindly': [1643], 'provided': [1644], '(11Morrissey': [1648], 'constructions': [1665, 2684], 'produce': [1668, 1708], 'derived': [1673], 'GAR1': [1676, 3546, 3674, 4630], 'open': [1677], 'reading': [1678], 'frame': [1679], 'inserted': [1680], 'pTZ18R.': [1682], '2J.': [1683], 'Girard': [1685], 'Lapeyre,': [1688, 3271], 'unpublished': [1689, 3272], 'observations.': [1690, 3273], 'Digestion': [1691], 'various': [1693, 3583], 'restriction': [1694], 'enzymes': [1695], 'subcloning': [1697], 'polymerase': [1701, 1716], 'chain': [1702], 'reaction': [1703], 'fragments': [1704], 'several': [1709, 1815, 2597, 2906, 4111, 4345], 'deletions.': [1711], 'Transcription': [1712], 'using': [1713, 1789, 1902, 2418, 3722], 'T7': [1714], 'performed': [1718], 'according': [1719, 1784], "supplier's": [1722], 'instructions': [1723], '(Promega).': [1724], 'purified': [1727, 2132], 'over': [1728], 'G-25': [1730], 'spin': [1731], 'column,': [1732], 'phenol': [1733], 'extracted,': [1734], 'ethanol': [1736], 'precipitated': [1737, 2160, 2180], 'before': [1738], 'translation.': [1739], 'Biotinylated': [1740], 'obtained': [1743, 2698], 'performing': [1745], 'transcription': [1747], 'presence': [1750, 1796, 2440, 3199, 4102], '100': [1752, 2352], 'μm': [1753], 'biotin-21-UTP': [1754], '(CLONTECH).': [1755], 'Conditions': [1756], 'optimized': [1758], 'obtain': [1760], 'molecules': [1762, 2169, 2184], 'containing': [1763, 1858], 'amount': [1766], 'biotin,': [1768], 'avidin-alkaline': [1772], 'phosphatase': [1773], 'assay': [1774, 2063], '(Bio-reaction).35S-Labeled': [1775], 'derivatives': [1777], 'made': [1779, 2106], 'wheat': [1781, 2108], 'germ': [1782, 2109], 'extract': [1783, 2110], 'manufacturer': [1787], '(Promega)': [1788], '1': [1790, 1823, 1831], 'μg': [1791, 1860], 'mRNA': [1793], '15': [1798, 1932], 'μCi': [1799], '[35S]methionine': [1800], '(1200': [1801], 'Ci/mmol).': [1802], '35S': [1804], 'stored': [1807], '−20': [1809], '°C': [1810, 1927, 3555], 'thawed': [1812], 'frozen': [1814], 'times': [1816, 1912, 2466], 'apparent': [1818], 'loss': [1819, 3539], 'capacity.': [1822], 'fmol': [1824], '35S-Gar1p': [1826], 'derivative': [1827], 'incubated': [1829, 2112, 2432], 'pmol': [1832], 'volume': [1838], '30': [1840, 1868], 'μl': [1841, 1871, 1877, 1915, 1933], 'buffer': [1844, 1874, 1889], '(20': [1845], 'mm': [1846, 1851, 1854, 2270, 2294, 2353, 2360, 2384], 'Tris-Cl,': [1847], 'pH': [1848], '9.5,': [1849], '20': [1850, 2465], 'MgCl2,': [1852], '10': [1853, 1929], 'KCl,': [1855], '0.25%': [1856], 'Nonidet-P40)': [1857], '4': [1859, 2675, 2729, 2744, 3165, 3186], 'tRNA.': [1863], 'After': [1864, 1892], '60': [1865, 4257], 'min': [1866, 1894, 1930], '°C,': [1869], '350': [1870], '7': [1876], 'beads': [1879, 1899, 2200], '(Dynabeads': [1880], 'M-280': [1881], 'streptavidin,': [1882], 'Dynal)': [1883], 'washed': [1885, 1910], 'same': [1888], 'added.': [1891], '90': [1893], 'room': [1896], 'temperature,': [1897], 'recovered': [1901], 'magnet': [1904], '(Dynal': [1905], 'MPC).': [1906], 'pellet': [1908], 'three': [1911, 4503], '500': [1914, 2269, 2359], 'buffer,': [1918], 'bound': [1921, 2143], 'eluted': [1924], '95': [1926], 'SDS-PAGE': [1935], 'sample': [1936], 'buffer.': [1937], 'supernatant': [1939], 'analyzed': [1941, 2003, 2148, 3718], '15%': [1943, 2150], 'SDS-PAGE,': [1944], 'exposed': [1946], 'on': [1947, 2248, 3587, 4768, 4776], 'Kodak': [1948], 'film': [1949], '1–3': [1951], 'days.': [1952], 'competition': [1954, 2416], 'experiments,': [1955], 'competitor': [1957, 2125, 2420, 2454, 2482], 'mixed': [1960], 'biotinylated': [1963, 2115, 2171, 2207, 2434, 2478, 2741], 'prior': [1965], 'incubation': [1967], 'labeled': [1970], 'Cultures': [1972], 'liquid': [1976], 'A600:nm': [1980], '1,': [1982], 'then': [1983, 2141], 'extracted': [1986], '(21Tollervey': [1990], '6:': [1995, 2096], '4169-4175Crossref': [1996], '(247)': [1999], 'Northern': [2005, 3720], 'blots.': [2006], 'To': [2046, 3577, 3894], 'assess': [2047, 3578], '(22Scherly': [2064], 'Boelens': [2066], 'W.,': [2067], 'van': [2068], 'Venroaij': [2069], 'Dathan': [2071], 'N.A.': [2072], 'Hamm': [2073], 'Mattaj': [2075, 2091, 5023], 'I.W.': [2076, 2092], '4163-4170Crossref': [2081], '(272)': [2084], '23Hamm': [2087], 'Kazmaier': [2089], '3479-3485Crossref': [2097], '(98)': [2100], '35S-Labeled': [2103], 'synthetic': [2114], 'excess': [2120, 2468], 'tRNA': [2122], 'nonspecific': [2127, 2227, 2426, 2481], 'interactions.': [2128, 2502], 'Biotin-containing': [2129], 'precipitation': [2134], 'streptavidin': [2136, 2203], 'coupled': [2137, 2201], 'magnetic': [2139, 2199], 'released': [2146], 'SDS-PAGE.': [2151], 'About': [2152], '50%': [2153], 'input': [2156], 'reproducibly': [2159], 'when': [2166, 2181, 2458, 3193, 3227, 4205, 4451], '(Fig.': [2172, 2362, 2450, 2728, 2743, 3042, 3164, 3185, 3353, 3459, 3731, 4390], '1,lanes': [2173], 'c': [2174], 'e).': [2176], 'No': [2177, 3603], 'nonbiotinylated': [2182, 2445, 2453], '(lanes': [2187], 'b': [2188], 'andd),': [2189], 'indicating': [2190, 2755, 3848], 'specific': [2205], 'specificity': [2210, 2499], 'comparison': [2223], 'substrates': [2229], '(5′ETS': [2230], 'rRNA': [2231, 3588, 3600, 3627], 'human': [2236], 'U1': [2237], 'snRNA,lanes': [2238], 'f': [2239], 'g).': [2241], 'effect': [2243, 2457, 3580], 'ionic': [2246], 'strength': [2247], 'stability': [2250], 'RNA-protein': [2253], 'complex': [2254, 3873, 4242, 4871], 'tested.': [2257], 'contrast': [2259, 2367, 2771, 3946], 'retains': [2266, 2290, 2806], 'NaCl': [2271, 2295], 'A1,': [2288], '250': [2293], '(24Cobianchi': [2296], 'Karpel': [2298], 'R.L.': [2299], 'Williams': [2300, 2332], 'K.R.': [2301, 2333], 'Notario': [2302], 'V.': [2303], 'Wilson': [2304, 2330], 'S.H.': [2305, 2331, 4060], '1988;': [2309], '263:': [2310], '1063-1071Abstract': [2311], '25Nadler': [2318], 'S.G.': [2319], 'Merrill': [2320], 'B.M.': [2321], 'Roberts': [2322], 'W.J.': [2323], 'Keating': [2324], 'K.M.': [2325], 'Lisbin': [2326], 'Barnett': [2328], 'S.F.': [2329], 'Biochemistry.': [2334], '30:': [2336], '2968-2976Crossref': [2337], '(79)': [2340], 'exhibits': [2344, 4310], 'decreased': [2345], 'KCl': [2354, 2361, 2385], '2).': [2363], 'finding': [2370, 4813], 'native': [2372], 'intact': [2379], 'RNP': [2381, 4912], '600': [2383], '(26Lubben': [2386, 3966], 'Fabrizio': [2388, 3968], 'Kastner': [2390, 3970], 'Luhrmann': [2392, 3972], 'R.': [2393, 3973], '270:': [2398, 3978], '11549-11554Abstract': [2399, 3979], '(see': [2410], '"Discussion").': [2411], 'Then,': [2412], 'carried': [2414], 'out': [2415], 'experiments': [2417, 2696, 4531], 'snRNA': [2424, 5028], '35SLabeled': [2428], '(or': [2436, 2447], 'snR30)': [2437], 'increasing': [2442], 'amounts': [2443], 'snR10,': [2448], 'respectively)': [2449], '3).': [2451], 'little': [2456, 4509], 'equimolar': [2461], 'amounts,': [2462], 'molar': [2467], 'completely': [2470, 3176, 3629], 'abolishes': [2471, 3177, 3220, 4392], '(ETS': [2483], 'rRNA)': [2484], 'unable': [2486], 'displace': [2488], 'emphasizing': [2497], 'unlikely': [2505], 'possesses': [2508], 'sites': [2510], 'whole': [2525, 3142], 'set': [2526], 'common': [2532], 'located': [2574, 4370, 4775], 'ends': [2578], '(N-GAR': [2581], 'C-GAR)': [2583], 'recognizable': [2587], 'features': [2588, 2818], 'metabolism.': [2604], 'Moreover,': [2605, 3501], 'distantly': [2607], 'glycine-rich': [2609], '(hnRNP': [2611], 'U)': [2612], 'proposed': [2614], 'single-stranded': [2619], 'DNA': [2620], 'homopolymeric': [2622], 'investigated': [2640], 'series': [2654], 'deletions': [2656, 3584, 3609], 'constructed,': [2660], 'corresponding': [2663, 3724], 'tested': [2666, 2688], 'RNAs.': [2673], 'Fig.': [2674, 3171], 'schematically': [2677], 'presents': [2678, 2815], 'informative': [2681], 'summarizes': [2690], 'results': [2692], 'complementation': [2695, 4394], 'whenever': [2721], 'available.': [2724], 'construction': [2726, 2796, 3167, 3439, 4493, 4708], 'A),': [2730], 'lacks': [2732, 2799, 4502], 'B)': [2745], 'although': [2746, 4298], 'efficiently': [2748], 'than': [2749, 3070, 3126], 'wild-type': [2752, 3617, 4431], '(wt),': [2754], 'might': [2760, 3286], 'contribute': [2761, 4201], 'absolutely': [2765, 3149], 'interaction.': [2769, 4917], 'under': [2783], 'our': [2784], 'experimental': [2785], 'conditions': [2786], 'exemplified': [2793], 'E,': [2797, 3622], 'domains.': [2809, 4253], 'region': [2812], 'remarkable': [2817], 'except': [2819], 'stretch': [2822], 'basic': [2824, 2849], 'amino': [2825, 3027, 3059], 'acids': [2826, 3028, 3060], 'lysine': [2829], 'proline': [2831], 'resembles': [2833], 'nuclearization': [2835], 'sequences': [2836, 2911, 2968, 3022], 'many': [2839], 'proteins.': [2841, 4583], 'motif': [2850], 'does': [2851, 2866, 4474, 4964, 4975], 'work': [2853], 'signal': [2858], 'its': [2864, 3245, 3418, 4000, 4018, 4089, 4355, 4663, 4874], 'impair': [2868], 'accumulation': [2871], 'reporter': [2874, 4143, 4436], 'fused': [2876], 'Due': [2901], 'advance': [2904], 'genome': [2907], 'sequencing': [2908], 'projects,': [2909], 'partial': [2910], 'fromDrosophila': [2914], '(X71975),': [2915], 'Arabidopsis': [2916], 'thaliana(T21476)': [2917], '(27Newman': [2918], 'T.,': [2919], 'de': [2920], 'Bruijn': [2921], 'F.J.': [2922], 'Green': [2923], 'Keegstra': [2925], 'Kende': [2927], 'McIntosh': [2929], 'Ohlrogge': [2931], 'Raikhel': [2933], 'N.': [2934], 'Somerville': [2935, 2941], 'Thomashow': [2937], 'Retzel': [2939], 'E.': [2940], 'Plant': [2943], 'Physiol.': [2944], '(Bethesda).': [2945], '106:': [2947], '1241-1255Crossref': [2948], '(569)': [2951], 'species': [2956, 3039, 3154, 3366, 3828], 'Brassica': [2958], '(M64632': [2959], 'andM64633)': [2960], 'available': [2963], 'addition': [2965, 3129, 4353, 4550], 'Schizosaccharomyces': [2973], 'pombe': [2974, 3239], 'published': [2977], 'earlier': [2978], '28Girard': [3001], 'Nucleic': [3007], 'Acids': [3008], 'Res.': [3009], '21:': [3011], '2149-2155Crossref': [3012], '(23)': [3015], 'An': [3018], 'alignment': [3019, 3080], '109': [3026], '(wherever': [3031], 'available)': [3034], 'five': [3037], 'presented': [3041], '5).': [3043], 'Two': [3044], 'regions': [3045], 'very': [3047, 3463, 3824, 4508], 'striking': [3048, 4094], 'homology': [3049], 'denoted': [3051], 'Box-1': [3052, 3131, 3219, 4309, 4373], 'Box-2.': [3054, 4293], 'instance,': [3056, 4038, 4585], '25': [3058, 3598], 'Box-1,': [3062], 'exhibit': [3063], 'average': [3065], '90%': [3067], 'identity': [3068, 3122], '(more': [3069], '98%': [3071], 'similarity)': [3072], 'Box-2,': [3078, 4506], 'excellent': [3083], 'andDrosophila,': [3087], 'variation': [3093], 'half': [3095], 'thaliana.': [3101], 'Since': [3102, 3381, 4876], 'some': [3105, 4027, 4311, 4363, 4897], 'uncertainties': [3106], 'portion': [3109, 3161], 'sequence': [3112, 3121, 4099], 'species,': [3115], 'possible': [3118, 4350], 'greater': [3125], 'presented.': [3127], '-2,': [3133], 'number': [3137, 3826], 'examined.': [3155, 3602], 'removes': [3159], 'Box-2': [3163, 3194, 4533, 4565, 4656], 'A,': [3166], 'B;': [3168], 'see': [3169], '5,': [3172], 'position': [3173, 3351, 3372, 4388], '124)': [3174], 'B,lanes': [3187], 'h': [3188], 'i).': [3190], 'entirely': [3196], 'removed,': [3197], '(construction': [3204, 3224, 3234], 'C)': [3205], 'rescue': [3207], 'activity.': [3213, 3291, 4365, 4597], 'affecting': [3218], 'activity': [3223, 4395], 'D)': [3225], 'E).': [3235], 'Interestingly,': [3236, 4918], 'substitute': [3243], 'homologue': [3246], 'cerevisiae,': [3249], 'interactin': [3254], 'budding': [3265, 3503], 'yeast.': [3266], '3C.': [3267], 'supports': [3276, 4840], 'idea': [3278], 'identical': [3280], 'segments': [3281], 'bear': [3287], 'Recently,': [3292], 'thermosensitive': [3294, 3790, 4627], 'allele': [3295, 3672, 3791, 4615, 4628], 'isolated': [3300, 3521], '(29Bousquet-Antonelli': [3303, 3675, 3800], 'Gélugne': [3307, 3679, 3804, 4948], 'J.-P.': [3308, 3680, 3805, 4949], '16:': [3316, 3688, 3813, 4957], '4770-4776Crossref': [3317, 3689, 3814, 4958], '(122)': [3320, 3692, 3817, 4961], 'mutant': [3324, 3743, 5000], 'multiple': [3326], 'mutations': [3327], 'lead': [3329, 4966], 'six': [3331], 'residue': [3332, 3358], 'changes,': [3333], 'one(s)': [3337], 'responsible': [3338], 'phenotype': [3341, 3533], 'mapped.': [3346], 'valine': [3349], '52': [3352], '5)': [3354, 4391], 'affected': [3359], 'invariant': [3362, 4272], '5': [3365, 4288], 'examined,': [3367], 'making': [3368], 'likely': [3369, 4654, 4865], 'B': [3384, 3440, 3612], 'while': [3417], 'strongly': [3426, 3457, 3562], 'impaired,': [3427], 'more': [3431, 3572, 4740], 'careful': [3432], 'examination': [3433, 3448], 'harboring': [3437, 4706], 'sole': [3443], 'source': [3444], 'Gar1p.': [3446], 'Microscopic': [3447], 'reveals': [3449], 'morphology': [3452, 4701], 'altered': [3458], '6).': [3460], 'Some': [3461], 'rounded,': [3466], 'others': [3468], 'abnormally': [3470, 3564], 'elongated': [3471], 'shape': [3474], 'resembling': [3475], 'starved': [3478], '(30Gimeno': [3481], 'C.J.': [3482], 'Ljungdahl': [3483], 'P.O.': [3484], 'Styles': [3485], 'C.A.': [3486], 'Fink': [3487], 'G.R.': [3488], '68:': [3491], '1077-1090Abstract': [3492], '(1003)': [3498], 'site': [3504, 4737], 'selection': [3505], 'deeply': [3510], 'affected,': [3511], 'newly': [3513], 'formed': [3514], 'shape.': [3519], 'abnormal': [3523, 4700, 4715, 4809], 'micro': [3526], 'manipulation': [3527], 'ascertain': [3529], 'observed': [3532, 3606, 4702, 4760], 'due': [3536, 4580], 'plasmid': [3542], 'carrying': [3543, 3788], 'modified': [3545], 'gene.': [3547], '37': [3554, 4263], 'division': [3557], 'impaired;': [3563], 'shaped': [3565], 'dead': [3569], 'prominent': [3573], 'culture.': [3576], 'accumulation,': [3589], 'steady': [3591, 3795], 'state': [3592, 3796], 'levels': [3593], '18': [3595, 3625], 'S': [3596, 3599, 3626], 'difference': [3604], 'compared': [3614], 'strain.': [3618], 'abolished': [3630], '(data': [3631], 'shown)': [3633], 'reported': [3636, 4905], 'depleted': [3640], 'expressing': [3669], 'conditional': [3671], 'Finally,': [3695], 'addressed': [3697], 'question': [3699], 'fate': [3702], 'vivo': [3707, 4559, 4895], 'differentGAR1': [3710], 'mutants.': [3711], 'prepared': [3713], 'mutants': [3716], 'blots,': [3721], 'clones': [3723], 'probes': [3730], '7).': [3732], 'Neither': [3733], 'nor': [3735], 'destabilized': [3740], 'strains.': [3744], 'confirms': [3746], 'previous': [3747, 3949], 'report': [3748, 3923, 3950], 'strains': [3751], 'deprived': [3752], 'use': [3757], 'GAL': [3760], 'inducible': [3761], 'version': [3762], 'changed': [3799], 'contains': [3822, 4287, 4496], 'both': [3839], '(10–15': [3841], 'S)': [3842, 3846], '(70–90': [3845], 'snoRNPs': [3850, 3914, 5016], 'exist': [3852], 'individual': [3857], 'particles': [3858, 4983], 'associate': [3863], 'and/or': [3867, 4755], 'following': [3871], 'pattern': [3874], 'affinities': [3876], '(31Maxwell': [3879], 'E.S.': [3880], 'Annu.': [3883], 'Rev.': [3884], '64:': [3887], '897-934Crossref': [3888], '(552)': [3891], 'how': [3896], 'machinery': [3899], 'operates,': [3900], 'necessary': [3903, 4131], 'provide': [3905, 4914], 'description': [3908, 5010], 'composition': [3911], 'constituents.': [3921], 'vitro.': [3936, 4513], 'noteworthy': [3939], 'salt-sensitive': [3944], 'association': [3953, 4858], 'resistant': [3961], 'high': [3963], 'salt': [3964], 'washes': [3965], 'One': [3990], 'possibility': [3991, 4012, 4798], 'optimal': [3995], 'requires': [4003, 4026], 'another': [4004, 4210], 'associate.': [4010], 'Another': [4011], 'target,': [4019], 'fully': [4023], 'active,': [4024], 'modifications': [4029], 'thein': [4031], 'translated': [4033], 'lacking.': [4036], 'dimethylated': [4051], 'mammalian': [4053], '(32Lapeyre': [4055], 'Ghaffari': [4059], 'Rao': [4061], 'S.V.': [4062], 'Dumbar': [4063], 'T.S.': [4064], 'Olson': [4065], 'M.O.': [4066], '1986;': [4070], '261:': [4071], '9167-9173Abstract': [4072], 'modification': [4080, 4801], 'stabilize': [4082], 'feature': [4095], 'showed': [4121], 'report,': [4172], 'revealed': [4176, 4240], 'Together,': [4214], 'hypothesis': [4219, 4696], 'dispensable': [4234], 'vivo.': [4236, 4486, 4526], 'organization': [4243, 4754], 'Domain': [4254, 4278, 4299, 4418, 4462, 4464, 4497, 4822], 'I': [4255, 4300, 4419, 4498], 'long,': [4259], 'extends': [4260, 4280], '96,': [4265], 'encompasses': [4267], '9': [4268], 'positions': [4273], 'Box-1.': [4277], 'II': [4279, 4302, 4500], '97': [4283], '146': [4285], 'noticeable': [4296], 'canonical': [4307], 'motifs,': [4308], 'similarities': [4312], 'Snm1p,': [4314], '(33Schmitt': [4324], 'M.E.': [4325], 'Clayton': [4326], 'D.A.': [4327], '2617-2628Crossref': [4332], '(81)': [4335], 'putative': [4340, 4618], 'DNA-polymerase': [4342], 'ATP-synthases.': [4346], 'thus': [4349], 'that,': [4351], 'activity,': [4358], 'bears': [4361], 'catalytic': [4364], 'upstream': [4371], 'must': [4374], 'removing': [4383], 'up': [4386], '54': [4389], 'complement': [4423], 'lacking': [4429], 'accumulate': [4434], 'nucleolus,': [4440], 'linked': [4454], 'II.': [4463], 'II,': [4465], 'properties': [4480], 'interesting': [4489, 4797], 'note': [4491], 'B,': [4494], 'activityin': [4512], 'conclude': [4528], 'vitro,': [4541], 'requirement': [4544], 'overridden': [4547], 'seems': [4556], 'lack': [4561], 'complete': [4564], 'partially': [4569], 'compensated,': [4570], 'absence': [4574], 'probably': [4579], 'may': [4590, 4988], 'compensate': [4591], 'defect': [4594, 4720], 'unwinding': [4596], 'Alternatively,': [4598], 'achieved': [4603], 'helicases': [4606], 'helicase': [4620], 'Rok1p': [4621], 'synthetically': [4623], '(34Venema': [4631], 'Bousquet-Antonelli': [4633], 'Gelugne': [4635], '17:': [4645], '3398-3407Crossref': [4646], '(89)': [4649], 'performs': [4657], 'functions': [4659, 4837], 'vivo,': [4661], 'At': [4692], 'least': [4693], 'explain': [4698], 'leads': [4717], 'ribosome': [4722], 'alters': [4725], 'translation': [4727], 'certain': [4729], 'factors': [4730], 'proliferation': [4734], 'bud': [4736, 4792], 'selection.': [4738], 'consequence': [4742], 'mutation': [4746], 'change': [4751], 'location': [4763], 'depends': [4767], 'polarity': [4770], 'always': [4774], 'opposite': [4778], 'side': [4779], 'spindle': [4782], 'pole': [4783], 'body,': [4784], 'itself': [4787], 'points': [4788], 'toward': [4789], 'future': [4791], 'site.': [4793], 'polarity.': [4811], 'coincides': [4820], 'I,': [4823], 'view': [4842], 'co-transported': [4851], 'perform': [4873], 'salt-sensitive,': [4887], 'tighter': [4916], 'depletion': [4919], '29Bousquet-Antonelli': [4944], 'instability.': [4969], 'suggests': [4972], 'protect': [4993], 'being': [4996], 'degraded': [4997], 'thegar1': [4999], 'cells.': [5001], 'characterization': [5003], 'should': [5007], 'build': [5018], 'up.': [5019], 'thank': [5021], 'I.': [5022], 'gift': [5026], 'ofU1': [5027], 'U1A': [5030], 'providing': [5036], 'SNR10': [5037], 'SNR30': [5039], 'genes.': [5040], 'grateful': [5043], 'his': [5048], 'continuous': [5049], 'colleagues': [5053], 'Toulouse': [5055], 'help': [5058], 'fruitful': [5060], 'discussions.': [5061]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2128045605', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-11T20:53:50.239417', 'created_date': '2016-06-24'}
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