Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2127797490', 'doi': 'https://doi.org/10.1083/jcb.133.5.1109', 'title': 'Endoglin modulates cellular responses to TGF-beta 1.', 'display_name': 'Endoglin modulates cellular responses to TGF-beta 1.', 'publication_year': 1996, 'publication_date': '1996-06-01', 'ids': {'openalex': 'https://openalex.org/W2127797490', 'doi': 'https://doi.org/10.1083/jcb.133.5.1109', 'mag': '2127797490', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8655583', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2120857'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1083/jcb.133.5.1109', 'pdf_url': 'https://rupress.org/jcb/article-pdf/133/5/1109/1064358/1109.pdf', 'source': {'id': 'https://openalex.org/S96410829', 'display_name': 'The Journal of Cell Biology', 'issn_l': '0021-9525', 'issn': ['0021-9525', '1540-8140'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://rupress.org/jcb/article-pdf/133/5/1109/1064358/1109.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5042827152', 'display_name': 'Pedro Lastres', 'orcid': 'https://orcid.org/0000-0002-5996-1426'}, 'institutions': [{'id': 'https://openalex.org/I4210147680', 'display_name': 'Centro de Investigaciones Biológicas Margarita Salas', 'ror': 'https://ror.org/04advdf21', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I4210147680']}, {'id': 'https://openalex.org/I134820265', 'display_name': 'Consejo Superior de Investigaciones Científicas', 'ror': 'https://ror.org/02gfc7t72', 'country_code': 'ES', 'type': 'government', 'lineage': ['https://openalex.org/I134820265']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'P Lastres', 'raw_affiliation_strings': ['Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.', 'institution_ids': ['https://openalex.org/I4210147680', 'https://openalex.org/I134820265']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073803799', 'display_name': 'Ainhoa Letamendı́a', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I134820265', 'display_name': 'Consejo Superior de Investigaciones Científicas', 'ror': 'https://ror.org/02gfc7t72', 'country_code': 'ES', 'type': 'government', 'lineage': ['https://openalex.org/I134820265']}, {'id': 'https://openalex.org/I4210147680', 'display_name': 'Centro de Investigaciones Biológicas Margarita Salas', 'ror': 'https://ror.org/04advdf21', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I4210147680']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'A Letamendía', 'raw_affiliation_strings': ['Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.', 'institution_ids': ['https://openalex.org/I134820265', 'https://openalex.org/I4210147680']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039583694', 'display_name': 'H Zhang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I134820265', 'display_name': 'Consejo Superior de Investigaciones Científicas', 'ror': 'https://ror.org/02gfc7t72', 'country_code': 'ES', 'type': 'government', 'lineage': ['https://openalex.org/I134820265']}, {'id': 'https://openalex.org/I4210147680', 'display_name': 'Centro de Investigaciones Biológicas Margarita Salas', 'ror': 'https://ror.org/04advdf21', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I4210147680']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'H Zhang', 'raw_affiliation_strings': ['Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.', 'institution_ids': ['https://openalex.org/I134820265', 'https://openalex.org/I4210147680']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040767863', 'display_name': 'Carlos Rı́us', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210147680', 'display_name': 'Centro de Investigaciones Biológicas Margarita Salas', 'ror': 'https://ror.org/04advdf21', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I4210147680']}, {'id': 'https://openalex.org/I134820265', 'display_name': 'Consejo Superior de Investigaciones Científicas', 'ror': 'https://ror.org/02gfc7t72', 'country_code': 'ES', 'type': 'government', 'lineage': ['https://openalex.org/I134820265']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'C Rius', 'raw_affiliation_strings': ['Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.', 'institution_ids': ['https://openalex.org/I4210147680', 'https://openalex.org/I134820265']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050563012', 'display_name': 'Nuria Almendro', 'orcid': 'https://orcid.org/0000-0002-8593-9812'}, 'institutions': [{'id': 'https://openalex.org/I4210147680', 'display_name': 'Centro de Investigaciones Biológicas Margarita Salas', 'ror': 'https://ror.org/04advdf21', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I4210147680']}, {'id': 'https://openalex.org/I134820265', 'display_name': 'Consejo Superior de Investigaciones Científicas', 'ror': 'https://ror.org/02gfc7t72', 'country_code': 'ES', 'type': 'government', 'lineage': ['https://openalex.org/I134820265']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'N Almendro', 'raw_affiliation_strings': ['Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.', 'institution_ids': ['https://openalex.org/I4210147680', 'https://openalex.org/I134820265']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068318882', 'display_name': 'Ulla Raab', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210147680', 'display_name': 'Centro de Investigaciones Biológicas Margarita Salas', 'ror': 'https://ror.org/04advdf21', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I4210147680']}, {'id': 'https://openalex.org/I134820265', 'display_name': 'Consejo Superior de Investigaciones Científicas', 'ror': 'https://ror.org/02gfc7t72', 'country_code': 'ES', 'type': 'government', 'lineage': ['https://openalex.org/I134820265']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'U Raab', 'raw_affiliation_strings': ['Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.', 'institution_ids': ['https://openalex.org/I4210147680', 'https://openalex.org/I134820265']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087820972', 'display_name': 'Lluís López-Barcons', 'orcid': 'https://orcid.org/0000-0001-9950-9090'}, 'institutions': [{'id': 'https://openalex.org/I4210147680', 'display_name': 'Centro de Investigaciones Biológicas Margarita Salas', 'ror': 'https://ror.org/04advdf21', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I4210147680']}, {'id': 'https://openalex.org/I134820265', 'display_name': 'Consejo Superior de Investigaciones Científicas', 'ror': 'https://ror.org/02gfc7t72', 'country_code': 'ES', 'type': 'government', 'lineage': ['https://openalex.org/I134820265']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'L A López', 'raw_affiliation_strings': ['Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.', 'institution_ids': ['https://openalex.org/I4210147680', 'https://openalex.org/I134820265']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035301007', 'display_name': 'Carmen Langa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210147680', 'display_name': 'Centro de Investigaciones Biológicas Margarita Salas', 'ror': 'https://ror.org/04advdf21', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I4210147680']}, {'id': 'https://openalex.org/I134820265', 'display_name': 'Consejo Superior de Investigaciones Científicas', 'ror': 'https://ror.org/02gfc7t72', 'country_code': 'ES', 'type': 'government', 'lineage': ['https://openalex.org/I134820265']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'C Langa', 'raw_affiliation_strings': ['Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.', 'institution_ids': ['https://openalex.org/I4210147680', 'https://openalex.org/I134820265']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062447219', 'display_name': 'Àngels Fabra', 'orcid': 'https://orcid.org/0000-0003-3288-523X'}, 'institutions': [{'id': 'https://openalex.org/I134820265', 'display_name': 'Consejo Superior de Investigaciones Científicas', 'ror': 'https://ror.org/02gfc7t72', 'country_code': 'ES', 'type': 'government', 'lineage': ['https://openalex.org/I134820265']}, {'id': 'https://openalex.org/I4210147680', 'display_name': 'Centro de Investigaciones Biológicas Margarita Salas', 'ror': 'https://ror.org/04advdf21', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I4210147680']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'A Fabra', 'raw_affiliation_strings': ['Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.', 'institution_ids': ['https://openalex.org/I134820265', 'https://openalex.org/I4210147680']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083610087', 'display_name': 'Michelle Letarte', 'orcid': 'https://orcid.org/0000-0002-5901-7582'}, 'institutions': [{'id': 'https://openalex.org/I4210147680', 'display_name': 'Centro de Investigaciones Biológicas Margarita Salas', 'ror': 'https://ror.org/04advdf21', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I4210147680']}, {'id': 'https://openalex.org/I134820265', 'display_name': 'Consejo Superior de Investigaciones Científicas', 'ror': 'https://ror.org/02gfc7t72', 'country_code': 'ES', 'type': 'government', 'lineage': ['https://openalex.org/I134820265']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'M Letarte', 'raw_affiliation_strings': ['Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.', 'institution_ids': ['https://openalex.org/I4210147680', 'https://openalex.org/I134820265']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5030749974', 'display_name': 'Carmelo Bernabéu', 'orcid': 'https://orcid.org/0000-0002-1563-6162'}, 'institutions': [{'id': 'https://openalex.org/I4210147680', 'display_name': 'Centro de Investigaciones Biológicas Margarita Salas', 'ror': 'https://ror.org/04advdf21', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I4210147680']}, {'id': 'https://openalex.org/I134820265', 'display_name': 'Consejo Superior de Investigaciones Científicas', 'ror': 'https://ror.org/02gfc7t72', 'country_code': 'ES', 'type': 'government', 'lineage': ['https://openalex.org/I134820265']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'C Bernabéu', 'raw_affiliation_strings': ['Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.', 'institution_ids': ['https://openalex.org/I4210147680', 'https://openalex.org/I134820265']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 6.856, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 304, 'citation_normalized_percentile': {'value': 0.999969, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '133', 'issue': '5', 'first_page': '1109', 'last_page': '1121'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11501', 'display_name': 'Transforming Growth Factor Beta Signaling Pathway', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11501', 'display_name': 'Transforming Growth Factor Beta Signaling Pathway', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10831', 'display_name': 'Integrin Signaling in Inflammation and Cancer', 'score': 0.9911, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11677', 'display_name': 'Molecular Mechanisms of Cardiac Development and Regeneration', 'score': 0.9806, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tgf-beta-1', 'display_name': 'TGF beta 1', 'score': 0.538592}, {'id': 'https://openalex.org/keywords/endothelial-cell-lineage-analysis', 'display_name': 'Endothelial Cell-Lineage Analysis', 'score': 0.488921}], 'concepts': [{'id': 'https://openalex.org/C6061869', 'wikidata': 'https://www.wikidata.org/wiki/Q18250377', 'display_name': 'Endoglin', 'level': 4, 'score': 0.9829694}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6553957}, {'id': 'https://openalex.org/C2778229498', 'wikidata': 'https://www.wikidata.org/wiki/Q24785672', 'display_name': 'Transforming growth factor beta', 'level': 3, 'score': 0.6228436}, {'id': 'https://openalex.org/C171020997', 'wikidata': 'https://www.wikidata.org/wiki/Q14911585', 'display_name': 'TGF beta receptor 2', 'level': 5, 'score': 0.5488747}, {'id': 'https://openalex.org/C53345823', 'wikidata': 'https://www.wikidata.org/wiki/Q5531554', 'display_name': 'Gene isoform', 'level': 3, 'score': 0.5447186}, {'id': 'https://openalex.org/C2781381406', 'wikidata': 'https://www.wikidata.org/wiki/Q14904613', 'display_name': 'TGF beta 1', 'level': 4, 'score': 0.538592}, {'id': 'https://openalex.org/C54009773', 'wikidata': 'https://www.wikidata.org/wiki/Q1429031', 'display_name': 'Transfection', 'level': 3, 'score': 0.52522254}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.5095806}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.45809537}, {'id': 'https://openalex.org/C118131993', 'wikidata': 'https://www.wikidata.org/wiki/Q423671', 'display_name': 'Transforming growth factor', 'level': 2, 'score': 0.44684356}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.4386551}, {'id': 'https://openalex.org/C86492073', 'wikidata': 'https://www.wikidata.org/wiki/Q413766', 'display_name': 'Fibronectin', 'level': 3, 'score': 0.4296023}, {'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.42281276}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.12483621}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.106452525}, {'id': 'https://openalex.org/C10205521', 'wikidata': 'https://www.wikidata.org/wiki/Q4035578', 'display_name': 'CD34', 'level': 3, 'score': 0.07540554}, {'id': 'https://openalex.org/C189165786', 'wikidata': 'https://www.wikidata.org/wiki/Q193825', 'display_name': 'Extracellular matrix', 'level': 2, 'score': 0.07319921}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D019010', 'descriptor_name': 'Vascular Cell Adhesion Molecule-1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015703', 'descriptor_name': 'Antigens, CD', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015214', 'descriptor_name': 'Antigens, Differentiation, Myelomonocytic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015214', 'descriptor_name': 'Antigens, Differentiation, Myelomonocytic', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015815', 'descriptor_name': 'Cell Adhesion Molecules', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015815', 'descriptor_name': 'Cell Adhesion Molecules', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002455', 'descriptor_name': 'Cell Division', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002455', 'descriptor_name': 'Cell Division', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017931', 'descriptor_name': 'DNA Primers', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017931', 'descriptor_name': 'DNA Primers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018076', 'descriptor_name': 'DNA, Complementary', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018076', 'descriptor_name': 'DNA, Complementary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071063', 'descriptor_name': 'Endoglin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005353', 'descriptor_name': 'Fibronectins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D005353', 'descriptor_name': 'Fibronectins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016259', 'descriptor_name': 'Genes, myc', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D016259', 'descriptor_name': 'Genes, myc', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016023', 'descriptor_name': 'Integrins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016023', 'descriptor_name': 'Integrins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019408', 'descriptor_name': 'Platelet Endothelial Cell Adhesion Molecule-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011956', 'descriptor_name': 'Receptors, Cell Surface', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018125', 'descriptor_name': 'Receptors, Transforming Growth Factor beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018125', 'descriptor_name': 'Receptors, Transforming Growth Factor beta', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018125', 'descriptor_name': 'Receptors, Transforming Growth Factor beta', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019010', 'descriptor_name': 'Vascular Cell Adhesion Molecule-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019010', 'descriptor_name': 'Vascular Cell Adhesion Molecule-1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1083/jcb.133.5.1109', 'pdf_url': 'https://rupress.org/jcb/article-pdf/133/5/1109/1064358/1109.pdf', 'source': {'id': 'https://openalex.org/S96410829', 'display_name': 'The Journal of Cell Biology', 'issn_l': '0021-9525', 'issn': ['0021-9525', '1540-8140'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2120857', 'pdf_url': 'https://europepmc.org/articles/pmc2120857?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2120857', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8655583', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1083/jcb.133.5.1109', 'pdf_url': 'https://rupress.org/jcb/article-pdf/133/5/1109/1064358/1109.pdf', 'source': {'id': 'https://openalex.org/S96410829', 'display_name': 'The Journal of Cell Biology', 'issn_l': '0021-9525', 'issn': ['0021-9525', '1540-8140'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 54, 'referenced_works': ['https://openalex.org/W1010135390', 'https://openalex.org/W127630602', 'https://openalex.org/W1480405375', 'https://openalex.org/W1484123114', 'https://openalex.org/W1494055834', 'https://openalex.org/W1523878042', 'https://openalex.org/W1568363145', 'https://openalex.org/W1576493498', 'https://openalex.org/W1578194145', 'https://openalex.org/W1590052782', 'https://openalex.org/W1599905111', 'https://openalex.org/W1601394191', 'https://openalex.org/W1812035827', 'https://openalex.org/W1902327771', 'https://openalex.org/W1949097444', 'https://openalex.org/W1965084403', 'https://openalex.org/W1968538228', 'https://openalex.org/W1969390276', 'https://openalex.org/W1969713456', 'https://openalex.org/W1975392093', 'https://openalex.org/W1980755859', 'https://openalex.org/W1994560336', 'https://openalex.org/W1997089935', 'https://openalex.org/W1997419670', 'https://openalex.org/W1997946316', 'https://openalex.org/W1999422736', 'https://openalex.org/W2013422219', 'https://openalex.org/W2014588425', 'https://openalex.org/W2019050177', 'https://openalex.org/W2020608323', 'https://openalex.org/W2021263701', 'https://openalex.org/W2038804998', 'https://openalex.org/W2041823687', 'https://openalex.org/W2052562309', 'https://openalex.org/W2060372234', 'https://openalex.org/W2062199188', 'https://openalex.org/W2066905497', 'https://openalex.org/W2072262157', 'https://openalex.org/W2080875081', 'https://openalex.org/W2084306312', 'https://openalex.org/W2085419002', 'https://openalex.org/W2098643301', 'https://openalex.org/W2103484049', 'https://openalex.org/W2107022932', 'https://openalex.org/W2107658520', 'https://openalex.org/W2112606757', 'https://openalex.org/W2116217777', 'https://openalex.org/W2131211068', 'https://openalex.org/W2134812217', 'https://openalex.org/W2144464927', 'https://openalex.org/W2169863019', 'https://openalex.org/W2301904930', 'https://openalex.org/W30147252', 'https://openalex.org/W4244662542'], 'related_works': ['https://openalex.org/W4240130371', 'https://openalex.org/W2349750750', 'https://openalex.org/W2159579113', 'https://openalex.org/W2147935740', 'https://openalex.org/W2127797490', 'https://openalex.org/W2102344606', 'https://openalex.org/W2062779245', 'https://openalex.org/W2036143395', 'https://openalex.org/W2023985048', 'https://openalex.org/W1518894649'], 'abstract_inverted_index': {'Endoglin': [0], 'is': [1, 26], 'a': [2, 207], 'homodimeric': [3], 'membrane': [4], 'glycoprotein': [5], 'which': [6, 68, 89, 231, 255], 'can': [7, 38], 'bind': [8], 'the': [9, 40, 50, 56, 109, 122, 127, 161, 189, 219, 222, 228, 252, 257], 'beta': [10, 13], '1': [11, 95, 151, 178, 239], 'and': [12, 48, 84, 105, 154, 168, 171, 179, 184], '3': [14], 'isoforms': [15], 'of': [16, 42, 59, 63, 81, 86, 113, 130, 134, 142, 166, 173, 218, 251, 259], 'transforming': [17], 'growth': [18], 'factor-beta': [19], '(TGF-beta).': [20], 'We': [21, 31], 'reported': [22], 'previously': [23], 'that': [24, 35], 'endoglin': [25, 43, 73, 162, 190, 232], 'upregulated': [27], 'during': [28], 'monocyte': [29], 'differentiation.': [30], 'have': [32], 'now': [33], 'observed': [34, 199], 'TGF-beta': [36, 94, 116, 138, 177, 238], 'itself': [37], 'stimulate': [39], 'expression': [41], 'in': [44, 49, 76, 96, 102, 108, 121, 124, 160, 188, 194, 200, 212, 224], 'cultured': [45], 'human': [46], 'monocytes': [47], 'U-937': [51, 64, 97, 135], 'monocytic': [52], 'line.': [53], 'To': [54], 'study': [55], 'functional': [57], 'role': [58], 'endoglin,': [60], 'stable': [61], 'transfectants': [62, 104, 202], 'cells': [65, 98, 136], 'were': [66, 99, 157, 198], 'generated': [67], 'overexpress': [69], 'L-': [70], 'or': [71, 245], 'S-': [72], 'isoforms,': [74], 'differing': [75], 'their': [77], 'cytoplasmic': [78], 'domain.': [79], 'Inhibition': [80, 112], 'cellular': [82, 145, 235], 'proliferation': [83, 114], 'downregulation': [85], 'c-myc': [87], 'mRNA': [88, 174], 'are': [90], 'normally': [91, 187], 'induced': [92], 'by': [93, 115, 230], 'totally': [100], 'abrogated': [101], 'L-endoglin': [103, 201], 'much': [106], 'reduced': [107], 'S-endoglin': [110, 213], 'transfectants.': [111, 163, 191, 214, 226], '2': [117], 'was': [118, 210, 221], 'not': [119], 'altered': [120], 'transfectants,': [123], 'agreement': [125], 'with': [126, 242], 'isoform': [128], 'specificity': [129], 'endoglin.': [131], 'Additional': [132], 'responses': [133, 236], 'to': [137, 204, 237], '1,': [139], 'including': [140], 'stimulation': [141, 172], 'fibronectin': [143], 'synthesis,': [144], 'adhesion,': [146], 'platelet/endothelial': [147], 'cell': [148], 'adhesion': [149], 'molecule': [150], '(PECAM-1)': [152], 'phosphorylation,': [153], 'homotypic': [155], 'aggregation': [156], 'also': [158], 'inhibited': [159], 'However,': [164], 'modulation': [165], 'integrin': [167], 'PECAM-1': [169], 'levels': [170, 175], 'for': [176], 'its': [180], 'receptors': [181], 'R-I,': [182], 'R-II,': [183], 'betaglycan': [185], 'occurred': [186], 'No': [192], 'changes': [193], 'total': [195], 'ligand': [196, 220, 243], 'binding': [197, 244], 'relative': [203], 'mock,': [205], 'while': [206], '1.5-fold': [208], 'increase': [209, 248], 'seen': [211], 'The': [215], 'degradation': [216, 246], 'rate': [217], 'same': [223], 'all': [225], 'Elucidating': [227], 'mechanism': [229], 'modulates': [233], 'several': [234], 'without': [240], 'interfering': [241], 'should': [247], 'our': [249], 'understanding': [250], 'complex': [253], 'pathways': [254], 'mediate': [256], 'effects': [258], 'this': [260], 'factor.': [261]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2127797490', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 15}], 'updated_date': '2024-09-13T14:43:58.933057', 'created_date': '2016-06-24'}