Pathways and therapeutic targets in melanoma

Name: Work Video:
Duration: 3 min 30 s
Emma Shtivelman; Michael A. Davies; Patrick Hwu; James C. Yang; Michal Lotem; Moshe Oren; Keith T. Flaherty; David E. Fisher
{'id': 'https://openalex.org/W2127765072', 'doi': 'https://doi.org/10.18632/oncotarget.1892', 'title': 'Pathways and therapeutic targets in melanoma', 'display_name': 'Pathways and therapeutic targets in melanoma', 'publication_year': 2014, 'publication_date': '2014-04-08', 'ids': {'openalex': 'https://openalex.org/W2127765072', 'doi': 'https://doi.org/10.18632/oncotarget.1892', 'mag': '2127765072', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24743024', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4039128'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.1892', 'pdf_url': 'https://www.oncotarget.com/article/1892/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/1892/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5029922928', 'display_name': 'Emma Shtivelman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210120668', 'display_name': 'Creative Commons', 'ror': 'https://ror.org/02ed4cj64', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210120668']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Emma Shtivelman', 'raw_affiliation_strings': ['Cancer Commons, Palo Alto, CA, USA.'], 'affiliations': [{'raw_affiliation_string': 'Cancer Commons, Palo Alto, CA, USA.', 'institution_ids': ['https://openalex.org/I4210120668']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048327749', 'display_name': 'Michael A. Davies', 'orcid': 'https://orcid.org/0000-0002-0977-0912'}, 'institutions': [{'id': 'https://openalex.org/I4210118383', 'display_name': 'Melanoma Institute Australia', 'ror': 'https://ror.org/02jxrhq31', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210118383']}, {'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['AU', 'US'], 'is_corresponding': False, 'raw_author_name': 'Michael A. Davies', 'raw_affiliation_strings': ['Melanoma Medical Oncology', 'University of Texas MD Anderson Cancer Center, Houston, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'Melanoma Medical Oncology', 'institution_ids': ['https://openalex.org/I4210118383']}, {'raw_affiliation_string': 'University of Texas MD Anderson Cancer Center, Houston, TX, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033798832', 'display_name': 'Patrick Hwu', 'orcid': 'https://orcid.org/0000-0002-8293-1313'}, 'institutions': [{'id': 'https://openalex.org/I4210118383', 'display_name': 'Melanoma Institute Australia', 'ror': 'https://ror.org/02jxrhq31', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210118383']}, {'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['AU', 'US'], 'is_corresponding': False, 'raw_author_name': 'Patrick Hwu', 'raw_affiliation_strings': ['Melanoma Medical Oncology', 'University of Texas MD Anderson Cancer Center, Houston, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'Melanoma Medical Oncology', 'institution_ids': ['https://openalex.org/I4210118383']}, {'raw_affiliation_string': 'University of Texas MD Anderson Cancer Center, Houston, TX, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101775177', 'display_name': 'James C. Yang', 'orcid': 'https://orcid.org/0000-0001-8935-5008'}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James Yang', 'raw_affiliation_strings': ['National Cancer Institute, NIH, Washington DC, USA'], 'affiliations': [{'raw_affiliation_string': 'National Cancer Institute, NIH, Washington DC, USA', 'institution_ids': ['https://openalex.org/I4210140884']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074296844', 'display_name': 'Michal Lotem', 'orcid': 'https://orcid.org/0000-0003-1703-8008'}, 'institutions': [], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Michal Lotem', 'raw_affiliation_strings': ['Hadassah Hebrew University Hospital, Jerusalem, Israel'], 'affiliations': [{'raw_affiliation_string': 'Hadassah Hebrew University Hospital, Jerusalem, Israel', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036387444', 'display_name': 'Moshe Oren', 'orcid': 'https://orcid.org/0000-0003-4311-7172'}, 'institutions': [{'id': 'https://openalex.org/I53964585', 'display_name': 'Weizmann Institute of Science', 'ror': 'https://ror.org/0316ej306', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I53964585']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Moshe Oren', 'raw_affiliation_strings': ['The Weizmann Institute of Science, Rehovot, Israel'], 'affiliations': [{'raw_affiliation_string': 'The Weizmann Institute of Science, Rehovot, Israel', 'institution_ids': ['https://openalex.org/I53964585']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023174631', 'display_name': 'Keith T. Flaherty', 'orcid': 'https://orcid.org/0000-0002-3402-0478'}, 'institutions': [{'id': 'https://openalex.org/I2801851002', 'display_name': 'Harvard University Press', 'ror': 'https://ror.org/006v7bf86', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I136199984', 'https://openalex.org/I2801851002']}, {'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Keith T. Flaherty', 'raw_affiliation_strings': ['Harvard University', 'Massachusetts General Hospital Cancer Center, Boston, MA, USA'], 'affiliations': [{'raw_affiliation_string': 'Harvard University', 'institution_ids': ['https://openalex.org/I2801851002']}, {'raw_affiliation_string': 'Massachusetts General Hospital Cancer Center, Boston, MA, USA', 'institution_ids': ['https://openalex.org/I4210087915']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5078874539', 'display_name': 'David E. Fisher', 'orcid': 'https://orcid.org/0000-0002-5506-0575'}, 'institutions': [{'id': 'https://openalex.org/I2801851002', 'display_name': 'Harvard University Press', 'ror': 'https://ror.org/006v7bf86', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I136199984', 'https://openalex.org/I2801851002']}, {'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David E. Fisher', 'raw_affiliation_strings': ['Harvard University', 'Massachusetts General Hospital Cancer Center, Boston, MA, USA'], 'affiliations': [{'raw_affiliation_string': 'Harvard University', 'institution_ids': ['https://openalex.org/I2801851002']}, {'raw_affiliation_string': 'Massachusetts General Hospital Cancer Center, Boston, MA, USA', 'institution_ids': ['https://openalex.org/I4210087915']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 7, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.047, 'has_fulltext': False, 'cited_by_count': 204, 'citation_normalized_percentile': {'value': 0.999745, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '5', 'issue': '7', 'first_page': '1701', 'last_page': '1752'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11533', 'display_name': 'Melanoma and MAPK Pathways', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11533', 'display_name': 'Melanoma and MAPK Pathways', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10580', 'display_name': 'Immunotherapy and Immune Responses', 'score': 0.9965, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12576', 'display_name': 'vaccines and immunoinformatics approaches', 'score': 0.9959, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/targeted-therapy', 'display_name': 'Targeted Therapy', 'score': 0.5240726}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6465641}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.5344179}, {'id': 'https://openalex.org/C2781230642', 'wikidata': 'https://www.wikidata.org/wiki/Q492646', 'display_name': 'Targeted therapy', 'level': 3, 'score': 0.5240726}, {'id': 'https://openalex.org/C2777658100', 'wikidata': 'https://www.wikidata.org/wiki/Q180614', 'display_name': 'Melanoma', 'level': 2, 'score': 0.50615233}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.44972327}, {'id': 'https://openalex.org/C74909509', 'wikidata': 'https://www.wikidata.org/wiki/Q10387', 'display_name': 'Gerontology', 'level': 1, 'score': 0.38680598}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.36847007}, {'id': 'https://openalex.org/C161191863', 'wikidata': 'https://www.wikidata.org/wiki/Q199655', 'display_name': 'Library science', 'level': 1, 'score': 0.35105923}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.24052784}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D008545', 'descriptor_name': 'Melanoma', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D001343', 'descriptor_name': 'Autophagy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D003713', 'descriptor_name': 'Dendritic Cells', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005784', 'descriptor_name': 'Gene Amplification', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007167', 'descriptor_name': 'Immunotherapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047908', 'descriptor_name': 'Intracellular Signaling Peptides and Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D058990', 'descriptor_name': 'Molecular Targeted Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011379', 'descriptor_name': 'Prognosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D025521', 'descriptor_name': 'Tumor Suppressor Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.1892', 'pdf_url': 'https://www.oncotarget.com/article/1892/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4039128', 'pdf_url': 'https://europepmc.org/articles/pmc4039128?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039128', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24743024', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.1892', 'pdf_url': 'https://www.oncotarget.com/article/1892/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.54, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 357, 'referenced_works': ['https://openalex.org/W1217284267', 'https://openalex.org/W1493925539', 'https://openalex.org/W1508084728', 'https://openalex.org/W1576725879', 'https://openalex.org/W1588371609', 'https://openalex.org/W1605988205', 'https://openalex.org/W1790252519', 'https://openalex.org/W1923073040', 'https://openalex.org/W1950572133', 'https://openalex.org/W1965029629', 'https://openalex.org/W1966467063', 'https://openalex.org/W1967902354', 'https://openalex.org/W1969485126', 'https://openalex.org/W1969699510', 'https://openalex.org/W1970195561', 'https://openalex.org/W1971512164', 'https://openalex.org/W1973260880', 'https://openalex.org/W1974228534', 'https://openalex.org/W1977277180', 'https://openalex.org/W1979233636', 'https://openalex.org/W1982443780', 'https://openalex.org/W1983348452', 'https://openalex.org/W1985577088', 'https://openalex.org/W1986258970', 'https://openalex.org/W1986592297', 'https://openalex.org/W1987334928', 'https://openalex.org/W1987944936', 'https://openalex.org/W1988084636', 'https://openalex.org/W1988379285', 'https://openalex.org/W1988706339', 'https://openalex.org/W1989773675', 'https://openalex.org/W1990011632', 'https://openalex.org/W1991118625', 'https://openalex.org/W1991708036', 'https://openalex.org/W1992699637', 'https://openalex.org/W1992847016', 'https://openalex.org/W1993851289', 'https://openalex.org/W1994376203', 'https://openalex.org/W1995103178', 'https://openalex.org/W1996644629', 'https://openalex.org/W1997825389', 'https://openalex.org/W1998910084', 'https://openalex.org/W1999025555', 'https://openalex.org/W2001719099', 'https://openalex.org/W2003753849', 'https://openalex.org/W2004295816', 'https://openalex.org/W2005387270', 'https://openalex.org/W2005393395', 'https://openalex.org/W2006937936', 'https://openalex.org/W2007867839', 'https://openalex.org/W2008322756', 'https://openalex.org/W2008878539', 'https://openalex.org/W2008954479', 'https://openalex.org/W2009642188', 'https://openalex.org/W2012573463', 'https://openalex.org/W2013043293', 'https://openalex.org/W2013178885', 'https://openalex.org/W2014924370', 'https://openalex.org/W2015009944', 'https://openalex.org/W2015682571', 'https://openalex.org/W2016789384', 'https://openalex.org/W2017007251', 'https://openalex.org/W2017187984', 'https://openalex.org/W2018169163', 'https://openalex.org/W2018236302', 'https://openalex.org/W2018794234', 'https://openalex.org/W2019096287', 'https://openalex.org/W2019496774', 'https://openalex.org/W2019564564', 'https://openalex.org/W2019950585', 'https://openalex.org/W2020543365', 'https://openalex.org/W2020627452', 'https://openalex.org/W2021175628', 'https://openalex.org/W2022481874', 'https://openalex.org/W2023740950', 'https://openalex.org/W2024085992', 'https://openalex.org/W2024682110', 'https://openalex.org/W2027727316', 'https://openalex.org/W2028550791', 'https://openalex.org/W2029530216', 'https://openalex.org/W2029728313', 'https://openalex.org/W2030209169', 'https://openalex.org/W2032084331', 'https://openalex.org/W2032109805', 'https://openalex.org/W2032211985', 'https://openalex.org/W2033708806', 'https://openalex.org/W2034253224', 'https://openalex.org/W2035000040', 'https://openalex.org/W2035294512', 'https://openalex.org/W2036237603', 'https://openalex.org/W2036262371', 'https://openalex.org/W2036468894', 'https://openalex.org/W2037961312', 'https://openalex.org/W2038264590', 'https://openalex.org/W2038733728', 'https://openalex.org/W2039137278', 'https://openalex.org/W2040910597', 'https://openalex.org/W2040956995', 'https://openalex.org/W2041052361', 'https://openalex.org/W2041342251', 'https://openalex.org/W2043008717', 'https://openalex.org/W2043058822', 'https://openalex.org/W2043398720', 'https://openalex.org/W2043600567', 'https://openalex.org/W2044433744', 'https://openalex.org/W2045048651', 'https://openalex.org/W2045799644', 'https://openalex.org/W2046585589', 'https://openalex.org/W2048522531', 'https://openalex.org/W2048672579', 'https://openalex.org/W2049267118', 'https://openalex.org/W2050216284', 'https://openalex.org/W2050299776', 'https://openalex.org/W2050839565', 'https://openalex.org/W2051506850', 'https://openalex.org/W2052781279', 'https://openalex.org/W2053473615', 'https://openalex.org/W2053520756', 'https://openalex.org/W2054738595', 'https://openalex.org/W2055624262', 'https://openalex.org/W2056723407', 'https://openalex.org/W2057802075', 'https://openalex.org/W2058131718', 'https://openalex.org/W2058390096', 'https://openalex.org/W2058432785', 'https://openalex.org/W2059388879', 'https://openalex.org/W2059549347', 'https://openalex.org/W2059794606', 'https://openalex.org/W2060573548', 'https://openalex.org/W2061695178', 'https://openalex.org/W2062875827', 'https://openalex.org/W2063264144', 'https://openalex.org/W2063346434', 'https://openalex.org/W2064297593', 'https://openalex.org/W2064607012', 'https://openalex.org/W2065030089', 'https://openalex.org/W2065138691', 'https://openalex.org/W2065620201', 'https://openalex.org/W2065909963', 'https://openalex.org/W2066715779', 'https://openalex.org/W2066964346', 'https://openalex.org/W2067904749', 'https://openalex.org/W2068973642', 'https://openalex.org/W2070645893', 'https://openalex.org/W2070819820', 'https://openalex.org/W2071034864', 'https://openalex.org/W2072435450', 'https://openalex.org/W2072630073', 'https://openalex.org/W2073204890', 'https://openalex.org/W2073433320', 'https://openalex.org/W2073620629', 'https://openalex.org/W2074671154', 'https://openalex.org/W2074800061', 'https://openalex.org/W2074801788', 'https://openalex.org/W2076562130', 'https://openalex.org/W2076948707', 'https://openalex.org/W2077517114', 'https://openalex.org/W2080626878', 'https://openalex.org/W2080641261', 'https://openalex.org/W2081191528', 'https://openalex.org/W2083328622', 'https://openalex.org/W2083435672', 'https://openalex.org/W2083566287', 'https://openalex.org/W2084232727', 'https://openalex.org/W2085551560', 'https://openalex.org/W2086773265', 'https://openalex.org/W2086824544', 'https://openalex.org/W2088508388', 'https://openalex.org/W2089401318', 'https://openalex.org/W2090639530', 'https://openalex.org/W2090640662', 'https://openalex.org/W2091250703', 'https://openalex.org/W2093762704', 'https://openalex.org/W2094130001', 'https://openalex.org/W2095761326', 'https://openalex.org/W2096223992', 'https://openalex.org/W2096425009', 'https://openalex.org/W2096961646', 'https://openalex.org/W2097995306', 'https://openalex.org/W2098175570', 'https://openalex.org/W2098835477', 'https://openalex.org/W2099604307', 'https://openalex.org/W2099738485', 'https://openalex.org/W2100614336', 'https://openalex.org/W2100969832', 'https://openalex.org/W2101393037', 'https://openalex.org/W2101452250', 'https://openalex.org/W2101653483', 'https://openalex.org/W2101774229', 'https://openalex.org/W2101830020', 'https://openalex.org/W2102031533', 'https://openalex.org/W2102448788', 'https://openalex.org/W2102532180', 'https://openalex.org/W2102557111', 'https://openalex.org/W2102590483', 'https://openalex.org/W2102686544', 'https://openalex.org/W2103152130', 'https://openalex.org/W2103557568', 'https://openalex.org/W2103675014', 'https://openalex.org/W2104401785', 'https://openalex.org/W2104500293', 'https://openalex.org/W2105326129', 'https://openalex.org/W2105660237', 'https://openalex.org/W2105747169', 'https://openalex.org/W2106285227', 'https://openalex.org/W2106543129', 'https://openalex.org/W2107484016', 'https://openalex.org/W2108537717', 'https://openalex.org/W2109642908', 'https://openalex.org/W2110092116', 'https://openalex.org/W2110764732', 'https://openalex.org/W2111153762', 'https://openalex.org/W2111381709', 'https://openalex.org/W2111552061', 'https://openalex.org/W2111656699', 'https://openalex.org/W2112140640', 'https://openalex.org/W2112244123', 'https://openalex.org/W2112601576', 'https://openalex.org/W2112853593', 'https://openalex.org/W2114903025', 'https://openalex.org/W2115339711', 'https://openalex.org/W2116294169', 'https://openalex.org/W2116376943', 'https://openalex.org/W2116386978', 'https://openalex.org/W2117216774', 'https://openalex.org/W2117647921', 'https://openalex.org/W2118342755', 'https://openalex.org/W2118471749', 'https://openalex.org/W2118982164', 'https://openalex.org/W2119494825', 'https://openalex.org/W2119501346', 'https://openalex.org/W2119895292', 'https://openalex.org/W2119991871', 'https://openalex.org/W2120472737', 'https://openalex.org/W2122037714', 'https://openalex.org/W2122598294', 'https://openalex.org/W2123045121', 'https://openalex.org/W2123870972', 'https://openalex.org/W2124467126', 'https://openalex.org/W2124662474', 'https://openalex.org/W2125408763', 'https://openalex.org/W2125552027', 'https://openalex.org/W2125883153', 'https://openalex.org/W2126524529', 'https://openalex.org/W2126932404', 'https://openalex.org/W2127079528', 'https://openalex.org/W2127672686', 'https://openalex.org/W2127845119', 'https://openalex.org/W2128327828', 'https://openalex.org/W2129112725', 'https://openalex.org/W2130066229', 'https://openalex.org/W2131001269', 'https://openalex.org/W2131040858', 'https://openalex.org/W2131653833', 'https://openalex.org/W2131967786', 'https://openalex.org/W2132564070', 'https://openalex.org/W2132923173', 'https://openalex.org/W2133154786', 'https://openalex.org/W2133403796', 'https://openalex.org/W2133529849', 'https://openalex.org/W2134294894', 'https://openalex.org/W2134471382', 'https://openalex.org/W2134490812', 'https://openalex.org/W2135131549', 'https://openalex.org/W2135453874', 'https://openalex.org/W2135707184', 'https://openalex.org/W2136474966', 'https://openalex.org/W2136731993', 'https://openalex.org/W2137020485', 'https://openalex.org/W2137705897', 'https://openalex.org/W2137920881', 'https://openalex.org/W2138134458', 'https://openalex.org/W2139327979', 'https://openalex.org/W2139863489', 'https://openalex.org/W2140380780', 'https://openalex.org/W2140575188', 'https://openalex.org/W2141674733', 'https://openalex.org/W2142160537', 'https://openalex.org/W2143152083', 'https://openalex.org/W2143163879', 'https://openalex.org/W2143381422', 'https://openalex.org/W2144096834', 'https://openalex.org/W2144770054', 'https://openalex.org/W2145271723', 'https://openalex.org/W2145429129', 'https://openalex.org/W2146207872', 'https://openalex.org/W2146494327', 'https://openalex.org/W2147474070', 'https://openalex.org/W2147482894', 'https://openalex.org/W2147846735', 'https://openalex.org/W2148158431', 'https://openalex.org/W2148360952', 'https://openalex.org/W2148510816', 'https://openalex.org/W2148830146', 'https://openalex.org/W2149244682', 'https://openalex.org/W2149532361', 'https://openalex.org/W2149793889', 'https://openalex.org/W2150740687', 'https://openalex.org/W2150772498', 'https://openalex.org/W2151171671', 'https://openalex.org/W2151957163', 'https://openalex.org/W2152425711', 'https://openalex.org/W2152733195', 'https://openalex.org/W2153712501', 'https://openalex.org/W2153938645', 'https://openalex.org/W2154265087', 'https://openalex.org/W2154841567', 'https://openalex.org/W2155364136', 'https://openalex.org/W2155394921', 'https://openalex.org/W2155906069', 'https://openalex.org/W2155959680', 'https://openalex.org/W2156078931', 'https://openalex.org/W2156244509', 'https://openalex.org/W2156266404', 'https://openalex.org/W2157210705', 'https://openalex.org/W2157833274', 'https://openalex.org/W2157873170', 'https://openalex.org/W2158157784', 'https://openalex.org/W2159175397', 'https://openalex.org/W2159220884', 'https://openalex.org/W2159422854', 'https://openalex.org/W2160834915', 'https://openalex.org/W2160837378', 'https://openalex.org/W2161018320', 'https://openalex.org/W2161033773', 'https://openalex.org/W2161249280', 'https://openalex.org/W2161724145', 'https://openalex.org/W2162184613', 'https://openalex.org/W2162942873', 'https://openalex.org/W2163188200', 'https://openalex.org/W2164221986', 'https://openalex.org/W2164319358', 'https://openalex.org/W2164377001', 'https://openalex.org/W2164524616', 'https://openalex.org/W2164699117', 'https://openalex.org/W2164992400', 'https://openalex.org/W2164996207', 'https://openalex.org/W2165229668', 'https://openalex.org/W2165575701', 'https://openalex.org/W2166675034', 'https://openalex.org/W2166952326', 'https://openalex.org/W2167059308', 'https://openalex.org/W2168420784', 'https://openalex.org/W2169491358', 'https://openalex.org/W2170403104', 'https://openalex.org/W2170739773', 'https://openalex.org/W2170866900', 'https://openalex.org/W2171367970', 'https://openalex.org/W2171947218', 'https://openalex.org/W2328582512', 'https://openalex.org/W2464506247', 'https://openalex.org/W2560367415', 'https://openalex.org/W2572174216', 'https://openalex.org/W4234605168', 'https://openalex.org/W4234746319', 'https://openalex.org/W4299811786', 'https://openalex.org/W4376848401'], 'related_works': ['https://openalex.org/W4248678482', 'https://openalex.org/W4220823109', 'https://openalex.org/W3129818825', 'https://openalex.org/W2468522164', 'https://openalex.org/W2171435634', 'https://openalex.org/W2124622370', 'https://openalex.org/W2079772486', 'https://openalex.org/W2079364398', 'https://openalex.org/W2066581032', 'https://openalex.org/W1991879524'], 'abstract_inverted_index': {'//': [0, 90], 'Emma': [1, 87], 'Shtivelman': [2], '1': [3, 36], ',': [4, 9, 13, 17, 21, 25, 30], 'Michael': [5], 'A.': [6], 'Davies': [7], '2': [8, 12, 43], 'Patrick': [10], 'Hwu': [11], 'James': [14], 'Yang': [15], '3': [16, 54], 'Michal': [18], 'Lotem': [19], '4': [20, 62], 'Moshe': [22], 'Oren': [23], '5': [24, 69], 'Keith': [26], 'T.': [27], 'Flaherty': [28], '6': [29, 35, 77], 'and': [31, 125, 159, 182, 229, 235], 'David': [32], 'E.': [33], 'Fisher': [34], 'Cancer': [37, 49, 56, 81], 'Commons,': [38], 'Palo': [39], 'Alto,': [40], 'CA,': [41], 'USA': [42, 53, 61, 85], 'University': [44, 65], 'of': [45, 73, 122, 157, 180, 193, 209, 220, 240], 'Texas': [46], 'MD': [47], 'Anderson': [48], 'Center,': [50, 82], 'Houston,': [51], 'TX,': [52], 'National': [55], 'Institute,': [57], 'NIH,': [58], 'Washington': [59], 'DC,': [60], 'Hadassah': [63], 'Hebrew': [64], 'Hospital,': [66], 'Jerusalem,': [67], 'Israel': [68, 76], 'The': [70, 195, 223], 'Weizmann': [71], 'Institute': [72], 'Science,': [74], 'Rehovot,': [75], 'Massachusetts': [78], 'General': [79], 'Hospital': [80], 'Boston,': [83], 'MA,': [84], 'Correspondence:': [86], 'Shtivelman,': [88], 'email:': [89], 'Keywords': [91], ':': [92, 99, 104, 109], 'melanoma,': [93], 'targeted': [94, 158, 233], 'therapy,': [95], 'immune': [96, 161, 245], 'therapy': [97], 'Received': [98], 'March': [100], '19,': [101], '2014': [102, 107, 112], 'Accepted': [103], 'April': [105, 110], '07,': [106], 'Published': [108], '08,': [111], 'Abstract': [113], 'This': [114, 168], 'review': [115], 'aims': [116], 'to': [117, 227, 232, 244], 'summarize': [118], 'the': [119, 178, 186, 199, 207, 237, 241], 'current': [120], 'knowledge': [121], 'molecular': [123], 'pathways': [124], 'their': [126], 'clinical': [127, 221], 'relevance': [128], 'in': [129, 138, 146, 152, 166, 176, 185], 'melanoma.': [130], 'Metastatic': [131], 'melanoma': [132], 'was': [133], 'a': [134, 216], 'grim': [135], 'diagnosis,': [136], 'but': [137, 155], 'recent': [139], 'years': [140], 'tremendous': [141, 183], 'advances': [142, 175], 'have': [143, 171], 'been': [144], 'made': [145, 163], 'treatments.': [147], 'Chemotherapy': [148], 'provided': [149], 'little': [150], 'benefit': [151], 'these': [153], 'patients,': [154], 'development': [156, 208], 'new': [160, 210], 'approaches': [162], 'radical': [164], 'changes': [165], 'prognosis.': [167], 'would': [169], 'not': [170], 'happened': [172], 'without': [173], 'remarkable': [174], 'understanding': [177, 228, 236], 'biology': [179], 'disease': [181], 'progress': [184], 'genomic': [187], '(and': [188], 'other': [189], '"omics")': [190], 'scale': [191], 'analyses': [192], 'tumors.': [194], 'big': [196], 'problems': [197], 'facing': [198], 'field': [200], 'are': [201], 'no': [202], 'longer': [203], 'focused': [204], 'exclusively': [205], 'on': [206], 'treatment': [211], 'modalities,': [212], 'though': [213], 'this': [214], 'is': [215], 'very': [217], 'busy': [218], 'area': [219], 'research.': [222], 'focus': [224], 'shifted': [225], 'now': [226], 'overcoming': [230], 'resistance': [231], 'therapies,': [234], 'underlying': [238], 'causes': [239], 'heterogeneous': [242], 'responses': [243], 'therapy.': [246]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2127765072', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 15}, {'year': 2022, 'cited_by_count': 19}, {'year': 2021, 'cited_by_count': 20}, {'year': 2020, 'cited_by_count': 24}, {'year': 2019, 'cited_by_count': 22}, {'year': 2018, 'cited_by_count': 20}, {'year': 2017, 'cited_by_count': 24}, {'year': 2016, 'cited_by_count': 19}, {'year': 2015, 'cited_by_count': 28}, {'year': 2014, 'cited_by_count': 9}], 'updated_date': '2025-01-02T22:25:55.691237', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
