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'dimerization': [77], '2.': [78], 'The': [79, 95], 'majority': [80], 'bi-allelic': [84, 504, 678, 988], 'double,': [86], 'however,': [87], 'homozygous': [88, 446, 1100], 'have': [90, 577, 786, 848, 1103], 'been': [91, 836], 'described': [92], '3,': [93], '4.': [94], 'GATA2': [96, 109, 144, 281, 508, 529, 544, 579, 622, 674, 744, 749, 755, 768, 789, 883, 919, 1001, 1029, 1045, 1083], 'gene': [97, 305, 639, 813, 823, 851, 879, 913, 1106], 'encodes': [98], 'transcription': [100], 'factor': [101], 'involved': [102], 'normal': [104, 946, 970], 'hematopoiesis.': [105], 'Recent': [106], 'studies': [107], 'associated': [108, 548, 723, 980], 'double': [113, 399], 'improved': [116], 'overall': [117, 983], '(OS)': [119], '5,': [120, 574, 770, 1088], '6.': [121], 'In': [122, 135, 569, 772, 961, 1021], 'contrast,': [123], 'another': [124], 'study': [125, 1095], 'failed': [126], 'show': [128], 'any': [129], 'impact': [130, 1043], 'thereof': [131], 'on': [132, 202, 855], 'OS': [133, 324, 388, 931, 942, 1006], '1.': [134], 'this': [136], 'study,': [137], 'we': [138, 533, 576, 785, 804, 858, 873, 1023, 1039], 'investigate': [139], 'prognostic': [141, 870, 1042], 'significance': [142], 'cohort': [148, 780, 1058], '128': [150, 160, 614], 'patients': [151, 161, 234, 301, 518, 536, 796, 894], 'CEBPA-mutated': [153], 'AML.': [154, 456, 604, 708], 'Diagnostic': [155], 'bone': [156, 375], 'marrow': [157, 376], 'samples': [158], 'were': [166, 169, 200, 211, 235, 271, 325, 366, 378, 417, 420, 460, 469, 490, 510, 520, 546, 711, 721], 'analyzed.': [167], 'Patients': [168, 372], 'enrolled': [170, 201], 'between': [171, 397], '1999': [172], '2012': [174], 'included': [176], 'clinical': [179], 'trials': [180], 'ALFA': [183], '9801,': [185], '9802,': [186], '9803,': [187], '0701,': [188], '0702': [190], '(ClinicalTrials.gov': [191, 206], 'IDs:': [192], 'NCT': [193, 208], '00931138,': [194], '00880243,': [195], '00363025,': [196], '00927498,': [197], '00932412).': [198], 'Children': [199], 'ELAM02': [204], 'trial': [205], 'ID:': [207], '00149162).': [209], 'Studies': [210], 'approved': [212], 'local': [215], 'Institutional': [216], 'Review': [217], 'Boards': [218], 'conducted': [220], 'after': [221, 331], 'informed': [222], 'consent': [223], 'was': [224, 242, 302, 341, 407, 890, 932, 1035], 'obtained': [225], 'accordance': [227], 'Declaration': [230], 'Helsinki.': [232], 'All': [233, 414], 'treated': [236], 'intensive': [238], 'chemotherapy.': [239], 'Genomic': [240, 617], 'analyzed': [243], 'for': [244, 304, 385, 698, 867, 882], 'entire': [246], 'coding': [247], 'region': [248], 'CEBPA,': [250], 'WT1': [251], '(exon': [252, 258], '7': [253], '9),': [255], 'NPM1': [257, 699, 709], '12)': [259], 'using': [260, 308, 368, 410, 777], 'PCR': [261, 274], 'direct': [263], 'Sanger': [264], 'sequencing.': [265], 'FLT3': [266], 'internal': [267], 'tandem': [268], 'duplications': [269], '(FLT3-ITD)': [270], 'detected': [272, 449, 511, 534, 578, 624, 712, 787], 'fragment': [276], 'analysis': [277, 307], '7.': [278], 'We': [279, 431, 448, 541, 693], 'sequenced': [280], '(exons': [282], '4–6,': [283], 'aa291': [284], '466)': [286], 'according': [287, 672], 'Greif': [289], 'et': [290, 594, 801], 'al.': [291, 595, 802], '8.': [292], 'Additionally,': [293], 'high-quality': [294], 'RNA': [295], '70': [297], 'available': [303], 'expression': [306, 630, 814, 824, 852, 880, 1107], 'Affymetrix': [309], 'HG': [310], 'U133': [311], 'Plus': [312], '2.0': [313], 'microarrays': [314], '(Santa': [315], 'Clara,': [316], 'USA).': [317], 'Cumulative': [318], 'incidence': [319], 'relapse': [321], '(CIR)': [322], 'estimated': [326, 933], 'Kaplan–Meier': [329], 'method': [330], 'stratification': [332], 'trials.': [334], 'Death': [335], 'first': [337, 525, 1097], 'complete': [338], '(CR)': [340], 'taken': [342], 'account': [344], 'competing': [346], 'risk.': [347], 'Hazard': [348], 'ratios': [349], '(HR)': [350], 'given': [352, 664], '95%': [354], 'confidence': [355], 'intervals': [356], '(CI).': [357], 'CR': [358, 889], 'rates': [359], 'minimal': [361], 'residual': [362], 'disease': [363], '(MRD)': [364], 'response': [365], 'compared': [367, 1050, 1085], "Fisher's": [369, 411, 563], 'exact': [370, 412, 564], 'test.': [371, 413], 'who': [373], 'received': [374], 'transplantation': [377], 'censored': [379], 'at': [380, 585, 902, 934], 'date': [382], 'transplant': [384], 'CIR': [386, 901, 926], 'analyses': [389], '(n': [390, 464, 477, 484, 494, 500, 625, 646, 653, 1047, 1053], '=': [391, 465, 478, 485, 495, 501, 567, 626, 647, 654, 949, 959, 967, 973, 1048, 1054], '10).': [392], 'Comparison': [393], 'mutational': [395, 696], 'frequencies': [396], 'simple': [404, 436, 470], 'also': [408], 'performed': [409, 421], 'statistical': [415], 'tests': [416], 'two-tailed': [418], 'Stata/IC': [424], '12.1': [425], 'software': [426], '(StataCorp,': [427], 'College': [428], 'Station,': [429], 'TX).': [430], 'evaluated': [432, 694], 'CEPBA': [433, 1032, 1101, 1110], 'N-terminal-': [437], '(N-ter)': [438], 'C-terminal-': [440], '(C-ter),': [441], 'double-,': [443], 'mutations.': [447, 540], 'all': [450, 827], 'five': [451, 608, 828], 'subgroups': [452, 609, 830], 'Most': [457], 'them': [459], 'double-mutated': [461], '(dm)': [462], 'cases': [463, 473, 552, 584, 650, 727, 791, 944], '80;': [466], '63%),': [467], '32%': [468], '(sm)': [472], 'either': [475], 'N-ter-': [476, 499], '29;': [479], '23%),': [480], 'C-ter': [482], '12;': [486], '9%).': [487], 'Homozygous': [488], 'rare': [491], 'C-ter-': [493], '5;': [496], '4%)': [497], '2;': [502], '1%)': [503], '(Fig.': [506, 530], '1A).': [507], '29': [513], '(23%)': [514], 'mainly': [521], 'clustered': [522], 'within': [523, 613, 792, 1015], 'ZF': [526], '1B).': [531], 'Furthermore,': [532, 1093], 'three': [535, 788], 'different': [539], 'confirmed': [542, 1024, 1040], 'that': [543, 806, 841, 1099], 'significantly': [547, 924, 979], 'dm': [551, 808, 844, 865, 1017, 1061, 1081, 1111], '(29%,': [553], '4': [554], '41': [556], 'sm': [557, 583, 726, 731, 819], 'vs.': [558, 732, 751, 885, 956, 1066, 1070, 1091], '25': [559, 754], '87': [561], 'dm:': [562], 'test': [565], 'P': [566, 737, 757, 958], '0.022).': [568], 'contrast': [570, 773], 'previous': [572], 'reports': [573, 761], '8,': [575, 1063], 'small': [587], 'frequency': [588, 620], '4%': [590], 'has': [592], 'Green': [593], '9': [596, 1064], '(Table': [597], '1).': [598], 'GATA2-': [599], 'A:': [605], 'Frequency': [606], 'cases.': [615, 820, 887], 'B:': [616], 'location': [618], '29).': [627], 'C:': [628], 'Gene': [629], 'hierarchical': [631], 'clustering': [632], 'mutations,': [637], 'where': [638], 'probe': [640], 'sets': [641], 'shown': [643], 'rows': [645], '276),': [648], 'columns': [652], '70).': [655], 'Sample': [656], 'dendrogram': [657], 'sample': [659], '3D-principal': [660], 'component': [661], 'plot': [662], 'respective': [666], 'color': [667], 'code.': [668], 'D:': [669], 'Overall': [670], 'mutation.': [679], 'Presence': [680], 'represented': [682], 'orange': [685], 'line': [686], 'absence': [688], 'blue': [691], 'line.': [692], 'status': [697], 'FLT3-ITD,': [701], 'other': [703], 'important': [704], 'implicated': [706], '12': [714], '(9%)': [715], 'patients.': [719, 995], 'They': [720], 'specifically': [722], '(12': [728, 746], '40': [730], '0': [733, 752], '78': [735], 'dm,': [736], '<': [738, 758], '0.0001)': [739], 'mutually': [741], 'exclusive': [742], '93': [748], 'wild-type': [750, 1052, 1087], 'mutated,': [756], '0.0001).': [759], 'Previous': [760], 'no': [763, 1041], 'co-occurrence': [764], 'FLT3-ITD': [766, 794], '9.': [771], 'our': [775, 1057, 1094], 'finding': [776], 'larger': [779], 'patients,': [784], '10': [793, 1069], 'positive': [795], '(30%).': [797], 'Similarly': [798], 'Wouters': [800], '10,': [803], 'harbored': [810], 'specific': [812, 878], 'profile': [815, 825], 'distinct': [816], 'from': [817], 'However,': [821, 1038], 'had': [834], 'never': [835], 'determined.': [837], 'Our': [838], 'results': [839], 'demonstrate': [840], 'homozygous-': [842], 'similar': [850, 1075, 1105], 'signature.': [853], 'Based': [854], 'these': [856], 'data,': [857], 'pooled': [859], 'groups': [862], 'subsequent': [869], 'analysis.': [871, 929], 'Finally,': [872], 'did': [874, 1003], 'not': [875, 1004, 1014, 1036], 'detect': [876], 'signature': [881, 1108], 'non-mutated': [886], 'Overall,': [888], 'achieved': [891], '113': [893], '(88%),': [895], 'whom': [897], '36': [898], 'relapsed': [899], '(estimated': [900], '3': [903], '5': [905], 'years,': [906], '39%).': [907], 'Neither': [908], 'age': [909, 965], 'nor': [910], 'karyotype': [911, 947, 971], '(including': [915], 'NPM1,': [916], 'FLT3,': [917], 'type': [921], 'mutation)': [923], 'influenced': [925], 'multivariate': [928, 962], 'Five-year': [930], '58%': [935], 'whole': [938], 'cohort,': [939], 'longer': [941], '(P': [948, 966, 972], '0.05)': [950], 'biallelic': [953], '(dm': [955], 'sm,': [957], '0.03).': [960], 'analysis,': [963], 'younger': [964, 994], '0.020)': [968], '0.029)': [974], 'remained': [975], 'only': [977], 'factors': [978], 'better': [982, 1077], 'survival.': [984], 'Of': [985], 'note,': [986], 'occur': [990], 'more': [991], 'frequently': [992], 'More': [996], 'specifically,': [997], 'presence': [999], 'affect': [1005], 'general': [1012], 'neither.': [1020], 'conclusion,': [1022], 'strong': [1026], 'association': [1027], 'biallelic-mutations,': [1033], 'which': [1034], 'exclusive.': [1037], '25)': [1049], '62)': [1055], '(22': [1065], '58': [1067], '16)': [1071], 'trend': [1074], 'outcome': [1078], '6': [1089], '(18': [1090], '62).': [1092], 'provided': [1096], 'evidence': [1098], 'thus': [1113], 'may': [1114], 'be': [1115], 'considered': [1116], 'equivalent.': [1118], 'Authors': [1119], 'acknowledge': [1120], 'contribution': [1122], 'Nicolas': [1124, 1144], 'Duployez': [1125], 'PharmD,': [1126, 1150], 'Olivier': [1127], 'Nibourel': [1128], 'PharmD': [1129, 1157], 'PhD,': [1130, 1140, 1147], 'Nathalie': [1131], 'Helevaut,': [1132], 'Céline': [1133, 1137], 'Rodriguez,': [1134], 'Karine': [1135], 'Celli-Lebras,': [1136], 'Berthon': [1138], 'MD': [1139, 1146], 'Guy': [1141], 'Leverger': [1142], 'MD,': [1143, 1153], 'Boissel': [1145], 'Christine': [1148], 'Terré': [1149], 'Xavier': [1151], 'Thomas': [1152], 'Aline': [1155], 'Renneville': [1156], 'PhD.': [1158], 'Alice': [1159], 'Marceau-Renaut,1,2': [1160], 'Soizic': [1161], 'Guihard,1': [1162], 'Sylvie': [1163], 'Castaigne,3': [1164], 'Hervé': [1165], 'Dombret,4': [1166], 'Claude': [1167], 'Preudhomme,1,2': [1168], 'Meyling': [1169], 'Cheok1*': [1170], '1U837,': [1171], 'INSERM,': [1172], 'Lille,': [1173, 1184], 'France;': [1174, 1185, 1191], '2Hematology': [1175], 'Laboratory,': [1176], 'Biology': [1177], 'Pathology': [1179], 'Center,': [1180], 'Lille': [1181], 'University': [1182], 'Hospital,': [1183, 1189, 1196], '3Hematology': [1186], 'Department,': [1187], 'Versailles': [1188], 'Versailles,': [1190], '4ALFA': [1192], 'Cooperative': [1193], 'Group,': [1194], 'Saint-Louis': [1195], 'Paris,': [1197], 'France': [1198], 'Contract': [1199], 'grant': [1200], 'sponsors:': [1201], 'Institut': [1202], 'National': [1203], 'du': [1204], 'Cancer': [1205], '(INCa)-DHOS': [1206], 'Recherche': [1207], 'Translationnelle': [1208], '2010,': [1209], 'SIRIC': [1210], 'ONCOLille.': [1211]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2127666933', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2025-01-08T07:48:10.621900', 'created_date': '2016-06-24'}