Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2127519720', 'doi': 'https://doi.org/10.1080/10837450701481157', 'title': 'Protein Stability During Freezing: Separation of Stresses and Mechanisms of Protein Stabilization', 'display_name': 'Protein Stability During Freezing: Separation of Stresses and Mechanisms of Protein Stabilization', 'publication_year': 2007, 'publication_date': '2007-01-01', 'ids': {'openalex': 'https://openalex.org/W2127519720', 'doi': 'https://doi.org/10.1080/10837450701481157', 'mag': '2127519720', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17963151'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/10837450701481157', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S80622011', 'display_name': 'Pharmaceutical Development and Technology', 'issn_l': '1083-7450', 'issn': ['1083-7450', '1097-9867'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5081356261', 'display_name': 'Bakul Bhatnagar', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I140172145', 'display_name': 'University of Connecticut', 'ror': 'https://ror.org/02der9h97', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I140172145']}, {'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Bakul S. Bhatnagar', 'raw_affiliation_strings': ['College of Pharmacy, University of Minnesota, Minneapolis, MN, USA', 'School of Pharmacy, U-3092, University of Connecticut, Storrs, CT, USA'], 'affiliations': [{'raw_affiliation_string': 'School of Pharmacy, U-3092, University of Connecticut, Storrs, CT, USA', 'institution_ids': ['https://openalex.org/I140172145']}, {'raw_affiliation_string': 'College of Pharmacy, University of Minnesota, Minneapolis, MN, USA', 'institution_ids': ['https://openalex.org/I130238516']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089220952', 'display_name': 'Robin H. Bogner', 'orcid': 'https://orcid.org/0000-0003-3710-9889'}, 'institutions': [{'id': 'https://openalex.org/I140172145', 'display_name': 'University of Connecticut', 'ror': 'https://ror.org/02der9h97', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I140172145']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robin H. Bogner', 'raw_affiliation_strings': ['Institute of Materials Science, University of Connecticut, Storrs, CT, USA', 'School of Pharmacy, U-3092, University of Connecticut, Storrs, CT, USA'], 'affiliations': [{'raw_affiliation_string': 'Institute of Materials Science, University of Connecticut, Storrs, CT, USA', 'institution_ids': ['https://openalex.org/I140172145']}, {'raw_affiliation_string': 'School of Pharmacy, U-3092, University of Connecticut, Storrs, CT, USA', 'institution_ids': ['https://openalex.org/I140172145']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5064626648', 'display_name': 'Michael J. Pikal', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I140172145', 'display_name': 'University of Connecticut', 'ror': 'https://ror.org/02der9h97', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I140172145']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael J. Pikal', 'raw_affiliation_strings': ['Institute of Materials Science, University of Connecticut, Storrs, CT, USA', 'School of Pharmacy, U-3092, University of Connecticut, Storrs, CT, USA'], 'affiliations': [{'raw_affiliation_string': 'Institute of Materials Science, University of Connecticut, Storrs, CT, USA', 'institution_ids': ['https://openalex.org/I140172145']}, {'raw_affiliation_string': 'School of Pharmacy, U-3092, University of Connecticut, Storrs, CT, USA', 'institution_ids': ['https://openalex.org/I140172145']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.385, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 420, 'citation_normalized_percentile': {'value': 0.757039, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '12', 'issue': '5', 'first_page': '505', 'last_page': '523'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11124', 'display_name': 'Protein purification and stability', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11124', 'display_name': 'Protein purification and stability', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12048', 'display_name': 'Microencapsulation and Drying Processes', 'score': 0.994, 'subfield': {'id': 'https://openalex.org/subfields/1106', 'display_name': 'Food Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11663', 'display_name': 'Viral Infectious Diseases and Gene Expression in Insects', 'score': 0.991, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/congelation', 'display_name': 'Congelation', 'score': 0.6176484}, {'id': 'https://openalex.org/keywords/protein-stability', 'display_name': 'Protein Stability', 'score': 0.51521355}, {'id': 'https://openalex.org/keywords/redistribution', 'display_name': 'Redistribution', 'score': 0.47792798}], 'concepts': [{'id': 'https://openalex.org/C2780586759', 'wikidata': 'https://www.wikidata.org/wiki/Q16889688', 'display_name': 'Congelation', 'level': 2, 'score': 0.6176484}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5902675}, {'id': 'https://openalex.org/C2988375501', 'wikidata': 'https://www.wikidata.org/wiki/Q847556', 'display_name': 'Protein stability', 'level': 2, 'score': 0.51521355}, {'id': 'https://openalex.org/C74080474', 'wikidata': 'https://www.wikidata.org/wiki/Q7305975', 'display_name': 'Redistribution (election)', 'level': 3, 'score': 0.47792798}, {'id': 'https://openalex.org/C203036418', 'wikidata': 'https://www.wikidata.org/wiki/Q284256', 'display_name': 'Crystallization', 'level': 2, 'score': 0.43679002}, {'id': 'https://openalex.org/C207821765', 'wikidata': 'https://www.wikidata.org/wiki/Q405372', 'display_name': 'Instability', 'level': 2, 'score': 0.43109763}, {'id': 'https://openalex.org/C125388846', 'wikidata': 'https://www.wikidata.org/wiki/Q1325808', 'display_name': 'Ice crystals', 'level': 2, 'score': 0.42155787}, {'id': 'https://openalex.org/C148898269', 'wikidata': 'https://www.wikidata.org/wiki/Q1108792', 'display_name': 'Kinetics', 'level': 2, 'score': 0.41943198}, {'id': 'https://openalex.org/C43617362', 'wikidata': 'https://www.wikidata.org/wiki/Q170050', 'display_name': 'Chromatography', 'level': 1, 'score': 0.35345525}, {'id': 'https://openalex.org/C42360764', 'wikidata': 'https://www.wikidata.org/wiki/Q83588', 'display_name': 'Chemical engineering', 'level': 1, 'score': 0.35159367}, {'id': 'https://openalex.org/C97355855', 'wikidata': 'https://www.wikidata.org/wiki/Q11473', 'display_name': 'Thermodynamics', 'level': 1, 'score': 0.33857885}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.11102301}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.106113076}, {'id': 'https://openalex.org/C57879066', 'wikidata': 'https://www.wikidata.org/wiki/Q41217', 'display_name': 'Mechanics', 'level': 1, 'score': 0.09593025}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C120665830', 'wikidata': 'https://www.wikidata.org/wiki/Q14620', 'display_name': 'Optics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C62520636', 'wikidata': 'https://www.wikidata.org/wiki/Q944', 'display_name': 'Quantum mechanics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C94625758', 'wikidata': 'https://www.wikidata.org/wiki/Q7163', 'display_name': 'Politics', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C17744445', 'wikidata': 'https://www.wikidata.org/wiki/Q36442', 'display_name': 'Political science', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C199539241', 'wikidata': 'https://www.wikidata.org/wiki/Q7748', 'display_name': 'Law', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C127413603', 'wikidata': 'https://www.wikidata.org/wiki/Q11023', 'display_name': 'Engineering', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003451', 'descriptor_name': 'Cryoprotective Agents', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D011489', 'descriptor_name': 'Protein Denaturation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D003451', 'descriptor_name': 'Cryoprotective Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005615', 'descriptor_name': 'Freezing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006863', 'descriptor_name': 'Hydrogen-Ion Concentration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007053', 'descriptor_name': 'Ice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013816', 'descriptor_name': 'Thermodynamics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/10837450701481157', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S80622011', 'display_name': 'Pharmaceutical Development and Technology', 'issn_l': '1083-7450', 'issn': ['1083-7450', '1097-9867'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17963151', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 156, 'referenced_works': ['https://openalex.org/W109410918', 'https://openalex.org/W113354497', 'https://openalex.org/W125833218', 'https://openalex.org/W1276324155', 'https://openalex.org/W133658527', 'https://openalex.org/W1497363573', 'https://openalex.org/W1500111277', 'https://openalex.org/W1508367957', 'https://openalex.org/W1515459678', 'https://openalex.org/W1524600440', 'https://openalex.org/W1525207856', 'https://openalex.org/W1530937340', 'https://openalex.org/W1532747786', 'https://openalex.org/W1541087680', 'https://openalex.org/W1544380954', 'https://openalex.org/W1562907760', 'https://openalex.org/W1579340188', 'https://openalex.org/W1602974455', 'https://openalex.org/W1778245994', 'https://openalex.org/W1796435123', 'https://openalex.org/W1802213410', 'https://openalex.org/W1848427764', 'https://openalex.org/W184893011', 'https://openalex.org/W1849496189', 'https://openalex.org/W1857016296', 'https://openalex.org/W1938795206', 'https://openalex.org/W1965394699', 'https://openalex.org/W1968312956', 'https://openalex.org/W1968373450', 'https://openalex.org/W1968948623', 'https://openalex.org/W1971123380', 'https://openalex.org/W1971611205', 'https://openalex.org/W1975539689', 'https://openalex.org/W1978269358', 'https://openalex.org/W1978675586', 'https://openalex.org/W1979789694', 'https://openalex.org/W1979806209', 'https://openalex.org/W1982999905', 'https://openalex.org/W1984655166', 'https://openalex.org/W1986312111', 'https://openalex.org/W1986397390', 'https://openalex.org/W1987485093', 'https://openalex.org/W1987839412', 'https://openalex.org/W1988107141', 'https://openalex.org/W198888838', 'https://openalex.org/W1990747744', 'https://openalex.org/W1991723190', 'https://openalex.org/W1992996280', 'https://openalex.org/W1994283966', 'https://openalex.org/W1994342473', 'https://openalex.org/W1994643710', 'https://openalex.org/W1996663871', 'https://openalex.org/W1996718452', 'https://openalex.org/W1996955270', 'https://openalex.org/W1997834085', 'https://openalex.org/W1998061050', 'https://openalex.org/W1998361394', 'https://openalex.org/W2003713109', 'https://openalex.org/W2004402709', 'https://openalex.org/W2007897007', 'https://openalex.org/W2009148449', 'https://openalex.org/W2011608305', 'https://openalex.org/W2013518551', 'https://openalex.org/W2014616464', 'https://openalex.org/W2016405093', 'https://openalex.org/W2016491794', 'https://openalex.org/W2016697191', 'https://openalex.org/W2016861978', 'https://openalex.org/W2017025004', 'https://openalex.org/W2017341540', 'https://openalex.org/W2017717546', 'https://openalex.org/W2018100577', 'https://openalex.org/W2023273398', 'https://openalex.org/W2024567952', 'https://openalex.org/W2025240528', 'https://openalex.org/W2027150145', 'https://openalex.org/W2027944759', 'https://openalex.org/W2028161854', 'https://openalex.org/W2028764333', 'https://openalex.org/W2029147859', 'https://openalex.org/W2032656456', 'https://openalex.org/W2034047337', 'https://openalex.org/W2035340445', 'https://openalex.org/W2037326325', 'https://openalex.org/W2038634233', 'https://openalex.org/W2042108820', 'https://openalex.org/W2042199709', 'https://openalex.org/W2048199422', 'https://openalex.org/W2049990413', 'https://openalex.org/W2052936346', 'https://openalex.org/W2053209660', 'https://openalex.org/W2054907288', 'https://openalex.org/W2056786932', 'https://openalex.org/W2056890384', 'https://openalex.org/W2057246411', 'https://openalex.org/W2058008956', 'https://openalex.org/W2059564760', 'https://openalex.org/W2059889846', 'https://openalex.org/W2060558860', 'https://openalex.org/W2062258725', 'https://openalex.org/W2062938568', 'https://openalex.org/W2066662804', 'https://openalex.org/W2068426104', 'https://openalex.org/W2069950858', 'https://openalex.org/W2073437688', 'https://openalex.org/W2076529933', 'https://openalex.org/W2078221639', 'https://openalex.org/W2078714382', 'https://openalex.org/W2080538147', 'https://openalex.org/W2080842528', 'https://openalex.org/W2082849164', 'https://openalex.org/W2082971990', 'https://openalex.org/W2083815812', 'https://openalex.org/W2085787484', 'https://openalex.org/W2086060770', 'https://openalex.org/W2086323803', 'https://openalex.org/W2087399617', 'https://openalex.org/W2087517481', 'https://openalex.org/W2087922887', 'https://openalex.org/W2089890341', 'https://openalex.org/W2091595825', 'https://openalex.org/W2096854615', 'https://openalex.org/W2099649939', 'https://openalex.org/W2105574859', 'https://openalex.org/W2106743573', 'https://openalex.org/W2113306739', 'https://openalex.org/W2116198537', 'https://openalex.org/W2119269930', 'https://openalex.org/W2119850183', 'https://openalex.org/W2132019107', 'https://openalex.org/W2146688993', 'https://openalex.org/W2153585226', 'https://openalex.org/W2155429140', 'https://openalex.org/W2155450902', 'https://openalex.org/W2155934170', 'https://openalex.org/W2159640426', 'https://openalex.org/W2166622100', 'https://openalex.org/W224574185', 'https://openalex.org/W2398906487', 'https://openalex.org/W2412216134', 'https://openalex.org/W2428462069', 'https://openalex.org/W2469672798', 'https://openalex.org/W2479889741', 'https://openalex.org/W2485774056', 'https://openalex.org/W2488745678', 'https://openalex.org/W2492912893', 'https://openalex.org/W2504735158', 'https://openalex.org/W2936080653', 'https://openalex.org/W309309890', 'https://openalex.org/W3111876267', 'https://openalex.org/W331961242', 'https://openalex.org/W4232574220', 'https://openalex.org/W4242617068', 'https://openalex.org/W52227285', 'https://openalex.org/W587016150', 'https://openalex.org/W629842789'], 'related_works': ['https://openalex.org/W4304687910', 'https://openalex.org/W3091633967', 'https://openalex.org/W3033974681', 'https://openalex.org/W2904406568', 'https://openalex.org/W2504162599', 'https://openalex.org/W2064895301', 'https://openalex.org/W1999227340', 'https://openalex.org/W1992893745', 'https://openalex.org/W1981414266', 'https://openalex.org/W1514828523'], 'abstract_inverted_index': {'Although': [0], 'proteins': [1, 135], 'are': [2, 54, 203], 'often': [3], 'frozen': [4, 134, 192], 'during': [5, 25, 60, 102, 166], 'processing': [6], 'or': [7, 81], 'freeze-dried': [8], 'after': [9], 'formulation': [10, 233], 'to': [11, 20, 39, 97, 130, 150, 172, 177, 227], 'improve': [12], 'their': [13, 174], 'stability,': [14], 'they': [15], 'can': [16], 'undergo': [17], 'degradation': [18, 107], 'leading': [19, 38], 'losses': [21], 'in': [22, 68, 111, 140, 191, 206], 'biological': [23], 'activity': [24], 'the': [26, 30, 40, 55, 66, 98, 112, 118, 124, 131, 141, 152, 159, 162, 178, 195, 212, 220, 228], 'process.': [27, 180], 'During': [28], 'freezing,': [29], 'physical': [31], 'environment': [32], 'of': [33, 42, 65, 79, 88, 92, 100, 114, 120, 127, 133, 146, 155, 161, 189, 198, 211, 215, 222, 230, 237], 'a': [34, 104, 121], 'protein': [35, 46, 105, 169], 'changes': [36], 'dramatically': [37], 'development': [41, 229], 'stresses': [43, 58, 94, 129, 164, 217], 'that': [44], 'impact': [45], 'stability.': [47], 'Low': [48], 'temperature,': [49], 'freeze-concentration,': [50], 'and': [51, 62, 86, 108, 157, 171, 194, 234], 'ice': [52], 'formation': [53], 'three': [56], 'chief': [57], 'resulting': [59], 'cooling': [61], 'freezing.': [63], 'Because': [64], 'increase': [67], 'solute': [69], 'concentrations,': [70], 'freeze-concentration': [71], 'could': [72], 'also': [73, 204], 'facilitate': [74], 'second': [75], 'order': [76], 'reactions,': [77], 'crystallization': [78], 'buffer': [80], 'non-buffer': [82], 'components,': [83], 'phase': [84], 'separation,': [85], 'redistribution': [87], 'solutes.': [89], 'An': [90, 209], 'understanding': [91, 210], 'these': [93], 'is': [95, 149, 225], 'critical': [96], 'determination': [99], 'when': [101], 'freezing': [103, 156, 167, 216], 'suffers': [106], 'therefore': [109], 'important': [110], 'design': [113, 236], 'stabilizer': [115], 'systems.': [116], 'With': [117], 'exception': [119], 'few': [122], 'studies,': [123], 'relative': [125, 175, 213], 'contribution': [126, 176], 'various': [128, 153, 163], 'instability': [132], 'has': [136], 'not': [137], 'been': [138], 'addressed': [139], 'freeze-drying': [142], 'literature.': [143], 'The': [144, 181], 'purpose': [145], 'this': [147, 207], 'review': [148], 'describe': [151], 'stages': [154], 'examine': [158], 'consequences': [160], 'developing': [165], 'on': [168, 184], 'stability': [170], 'assess': [173], 'destabilization': [179], 'ongoing': [182], 'debate': [183], 'thermodynamic': [185], 'versus': [186], 'kinetic': [187], 'mechanisms': [188, 202, 224], 'stabilization': [190], 'environments': [193], 'current': [196], 'state': [197], 'knowledge': [199, 221], 'concerning': [200], 'those': [201], 'reviewed': [205], 'publication.': [208], 'contributions': [214], 'coupled': [218], 'with': [219], 'cryoprotection': [223], 'central': [226], 'more': [231], 'rational': [232], 'process': [235], 'stable': [238], 'lyophilized': [239], 'proteins.': [240]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2127519720', 'counts_by_year': [{'year': 2024, 'cited_by_count': 33}, {'year': 2023, 'cited_by_count': 33}, {'year': 2022, 'cited_by_count': 30}, {'year': 2021, 'cited_by_count': 41}, {'year': 2020, 'cited_by_count': 41}, {'year': 2019, 'cited_by_count': 28}, {'year': 2018, 'cited_by_count': 29}, {'year': 2017, 'cited_by_count': 18}, {'year': 2016, 'cited_by_count': 25}, {'year': 2015, 'cited_by_count': 23}, {'year': 2014, 'cited_by_count': 19}, {'year': 2013, 'cited_by_count': 21}, {'year': 2012, 'cited_by_count': 16}], 'updated_date': '2024-12-21T15:08:49.618885', 'created_date': '2016-06-24'}