Humanized System to Propagate Cord Blood-Derived Multipotent Mesenchymal Stromal Cells for Clinical Application

Name: Work Video:
Duration: 3 min 30 s
Andreas Reinisch; Christina Bartmann; Eva Rohde; Katharina Schallmoser; Vesna Bjelic‐Radisic; Gerhard Lanzer; Werner Linkesch; Dirk Strunk
{'id': 'https://openalex.org/W2127443288', 'doi': 'https://doi.org/10.2217/17460751.2.4.371', 'title': 'Humanized System to Propagate Cord Blood-Derived Multipotent Mesenchymal Stromal Cells for Clinical Application', 'display_name': 'Humanized System to Propagate Cord Blood-Derived Multipotent Mesenchymal Stromal Cells for Clinical Application', 'publication_year': 2007, 'publication_date': '2007-07-01', 'ids': {'openalex': 'https://openalex.org/W2127443288', 'doi': 'https://doi.org/10.2217/17460751.2.4.371', 'mag': '2127443288', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17635045'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.2217/17460751.2.4.371', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S156036346', 'display_name': 'Regenerative Medicine', 'issn_l': '1746-0751', 'issn': ['1746-0751', '1746-076X'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310321119', 'host_organization_name': 'Future Medicine', 'host_organization_lineage': ['https://openalex.org/P4310321119'], 'host_organization_lineage_names': ['Future Medicine'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5035554715', 'display_name': 'Andreas Reinisch', 'orcid': 'https://orcid.org/0000-0001-9333-7689'}, 'institutions': [{'id': 'https://openalex.org/I202276237', 'display_name': 'Medical University of Graz', 'ror': 'https://ror.org/02n0bts35', 'country_code': 'AT', 'type': 'funder', 'lineage': ['https://openalex.org/I202276237']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Andreas Reinisch', 'raw_affiliation_strings': ['Medical University, Department of Internal Medicine, Division of Hematology and Stem Cell Transplantation, Auenbrugger Pl. 38, A-8036, Graz, Austria.', 'Medical University, StemCell Cluster, Graz, Austria'], 'affiliations': [{'raw_affiliation_string': 'Medical University, Department of Internal Medicine, Division of Hematology and Stem Cell Transplantation, Auenbrugger Pl. 38, A-8036, Graz, Austria.', 'institution_ids': ['https://openalex.org/I202276237']}, {'raw_affiliation_string': 'Medical University, StemCell Cluster, Graz, Austria', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020525710', 'display_name': 'Christina Bartmann', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I202276237', 'display_name': 'Medical University of Graz', 'ror': 'https://ror.org/02n0bts35', 'country_code': 'AT', 'type': 'funder', 'lineage': ['https://openalex.org/I202276237']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Christina Bartmann', 'raw_affiliation_strings': ['Medical University, Department of Blood Group Serology and Transfusion Medicine, Graz, Austria', 'Medical University, Department of Internal Medicine, Division of Hematology and Stem Cell Transplantation, Auenbrugger Pl. 38, A-8036, Graz, Austria.', 'Medical University, StemCell Cluster, Graz, Austria'], 'affiliations': [{'raw_affiliation_string': 'Medical University, Department of Internal Medicine, Division of Hematology and Stem Cell Transplantation, Auenbrugger Pl. 38, A-8036, Graz, Austria.', 'institution_ids': ['https://openalex.org/I202276237']}, {'raw_affiliation_string': 'Medical University, StemCell Cluster, Graz, Austria', 'institution_ids': []}, {'raw_affiliation_string': 'Medical University, Department of Blood Group Serology and Transfusion Medicine, Graz, Austria', 'institution_ids': ['https://openalex.org/I202276237']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024617009', 'display_name': 'Eva Rohde', 'orcid': 'https://orcid.org/0000-0001-8692-886X'}, 'institutions': [{'id': 'https://openalex.org/I202276237', 'display_name': 'Medical University of Graz', 'ror': 'https://ror.org/02n0bts35', 'country_code': 'AT', 'type': 'funder', 'lineage': ['https://openalex.org/I202276237']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Eva Rohde', 'raw_affiliation_strings': ['Medical University, Department of Blood Group Serology and Transfusion Medicine, Graz, Austria', 'Medical University, StemCell Cluster, Graz, Austria'], 'affiliations': [{'raw_affiliation_string': 'Medical University, StemCell Cluster, Graz, Austria', 'institution_ids': []}, {'raw_affiliation_string': 'Medical University, Department of Blood Group Serology and Transfusion Medicine, Graz, Austria', 'institution_ids': ['https://openalex.org/I202276237']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029625483', 'display_name': 'Katharina Schallmoser', 'orcid': 'https://orcid.org/0000-0002-7204-0058'}, 'institutions': [{'id': 'https://openalex.org/I202276237', 'display_name': 'Medical University of Graz', 'ror': 'https://ror.org/02n0bts35', 'country_code': 'AT', 'type': 'funder', 'lineage': ['https://openalex.org/I202276237']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Katharina Schallmoser', 'raw_affiliation_strings': ['Medical University, Department of Blood Group Serology and Transfusion Medicine, Graz, Austria', 'Medical University, StemCell Cluster, Graz, Austria'], 'affiliations': [{'raw_affiliation_string': 'Medical University, StemCell Cluster, Graz, Austria', 'institution_ids': []}, {'raw_affiliation_string': 'Medical University, Department of Blood Group Serology and Transfusion Medicine, Graz, Austria', 'institution_ids': ['https://openalex.org/I202276237']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022097827', 'display_name': 'Vesna Bjelic‐Radisic', 'orcid': 'https://orcid.org/0000-0002-3749-4775'}, 'institutions': [{'id': 'https://openalex.org/I202276237', 'display_name': 'Medical University of Graz', 'ror': 'https://ror.org/02n0bts35', 'country_code': 'AT', 'type': 'funder', 'lineage': ['https://openalex.org/I202276237']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Vesna Bjelic-Radisic', 'raw_affiliation_strings': ['Medical University, Department of Gynaecology and Obstetrics, Graz, Austria'], 'affiliations': [{'raw_affiliation_string': 'Medical University, Department of Gynaecology and Obstetrics, Graz, Austria', 'institution_ids': ['https://openalex.org/I202276237']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008934156', 'display_name': 'Gerhard Lanzer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I202276237', 'display_name': 'Medical University of Graz', 'ror': 'https://ror.org/02n0bts35', 'country_code': 'AT', 'type': 'funder', 'lineage': ['https://openalex.org/I202276237']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Gerhard Lanzer', 'raw_affiliation_strings': ['Medical University, Department of Blood Group Serology and Transfusion Medicine, Graz, Austria'], 'affiliations': [{'raw_affiliation_string': 'Medical University, Department of Blood Group Serology and Transfusion Medicine, Graz, Austria', 'institution_ids': ['https://openalex.org/I202276237']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109262289', 'display_name': 'Werner Linkesch', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I202276237', 'display_name': 'Medical University of Graz', 'ror': 'https://ror.org/02n0bts35', 'country_code': 'AT', 'type': 'funder', 'lineage': ['https://openalex.org/I202276237']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Werner Linkesch', 'raw_affiliation_strings': ['Medical University, Department of Internal Medicine, Division of Hematology and Stem Cell Transplantation, Auenbrugger Pl. 38, A-8036, Graz, Austria.'], 'affiliations': [{'raw_affiliation_string': 'Medical University, Department of Internal Medicine, Division of Hematology and Stem Cell Transplantation, Auenbrugger Pl. 38, A-8036, Graz, Austria.', 'institution_ids': ['https://openalex.org/I202276237']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5015144738', 'display_name': 'Dirk Strunk', 'orcid': 'https://orcid.org/0000-0003-1810-867X'}, 'institutions': [{'id': 'https://openalex.org/I202276237', 'display_name': 'Medical University of Graz', 'ror': 'https://ror.org/02n0bts35', 'country_code': 'AT', 'type': 'funder', 'lineage': ['https://openalex.org/I202276237']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Dirk Strunk', 'raw_affiliation_strings': ['Medical University, Department of Internal Medicine, Division of Hematology and Stem Cell Transplantation, Auenbrugger Pl. 38, A-8036, Graz, Austria.', 'Medical University, StemCell Cluster, Graz, Austria'], 'affiliations': [{'raw_affiliation_string': 'Medical University, Department of Internal Medicine, Division of Hematology and Stem Cell Transplantation, Auenbrugger Pl. 38, A-8036, Graz, Austria.', 'institution_ids': ['https://openalex.org/I202276237']}, {'raw_affiliation_string': 'Medical University, StemCell Cluster, Graz, Austria', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 6.319, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 156, 'citation_normalized_percentile': {'value': 0.905001, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '2', 'issue': '4', 'first_page': '371', 'last_page': '382'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10176', 'display_name': 'Mesenchymal stem cell research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10176', 'display_name': 'Mesenchymal stem cell research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12264', 'display_name': 'Tissue Engineering and Regenerative Medicine', 'score': 0.9966, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10729', 'display_name': 'Electrospun Nanofibers in Biomedical Applications', 'score': 0.9936, 'subfield': {'id': 'https://openalex.org/subfields/2502', 'display_name': 'Biomaterials'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/multipotent-stem-cell', 'display_name': 'Multipotent Stem Cell', 'score': 0.58641994}, {'id': 'https://openalex.org/keywords/cord-blood', 'display_name': 'Cord blood', 'score': 0.51339877}], 'concepts': [{'id': 'https://openalex.org/C198826908', 'wikidata': 'https://www.wikidata.org/wiki/Q1922379', 'display_name': 'Mesenchymal stem cell', 'level': 2, 'score': 0.8230202}, {'id': 'https://openalex.org/C2910776680', 'wikidata': 'https://www.wikidata.org/wiki/Q862600', 'display_name': 'Multipotent Stem Cell', 'level': 4, 'score': 0.58641994}, {'id': 'https://openalex.org/C16930146', 'wikidata': 'https://www.wikidata.org/wiki/Q4381253', 'display_name': 'Stromal cell', 'level': 2, 'score': 0.54533917}, {'id': 'https://openalex.org/C2780914630', 'wikidata': 'https://www.wikidata.org/wiki/Q914952', 'display_name': 'Cord blood', 'level': 2, 'score': 0.51339877}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.4012444}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.38221937}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.37503478}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3371445}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.30356425}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.2884217}, {'id': 'https://openalex.org/C201750760', 'wikidata': 'https://www.wikidata.org/wiki/Q1896218', 'display_name': 'Progenitor cell', 'level': 3, 'score': 0.06307554}], 'mesh': [{'descriptor_ui': 'D005312', 'descriptor_name': 'Fetal Blood', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D008648', 'descriptor_name': 'Mesoderm', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D039902', 'descriptor_name': 'Multipotent Stem Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D017154', 'descriptor_name': 'Stromal Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D018952', 'descriptor_name': 'Antigens, CD34', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018952', 'descriptor_name': 'Antigens, CD34', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D005312', 'descriptor_name': 'Fetal Blood', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008648', 'descriptor_name': 'Mesoderm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D039902', 'descriptor_name': 'Multipotent Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D039902', 'descriptor_name': 'Multipotent Stem Cells', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D017154', 'descriptor_name': 'Stromal Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017154', 'descriptor_name': 'Stromal Cells', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.2217/17460751.2.4.371', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S156036346', 'display_name': 'Regenerative Medicine', 'issn_l': '1746-0751', 'issn': ['1746-0751', '1746-076X'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310321119', 'host_organization_name': 'Future Medicine', 'host_organization_lineage': ['https://openalex.org/P4310321119'], 'host_organization_lineage_names': ['Future Medicine'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17635045', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.52, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 70, 'referenced_works': ['https://openalex.org/W1534731743', 'https://openalex.org/W1876428604', 'https://openalex.org/W1960997296', 'https://openalex.org/W1965953554', 'https://openalex.org/W1967241081', 'https://openalex.org/W1969281312', 'https://openalex.org/W1970590929', 'https://openalex.org/W1972171120', 'https://openalex.org/W1978969115', 'https://openalex.org/W1982408656', 'https://openalex.org/W1982666000', 'https://openalex.org/W1983259364', 'https://openalex.org/W1984180661', 'https://openalex.org/W1994586809', 'https://openalex.org/W1996789930', 'https://openalex.org/W1998428445', 'https://openalex.org/W2001352008', 'https://openalex.org/W2002218662', 'https://openalex.org/W2002320509', 'https://openalex.org/W2008930096', 'https://openalex.org/W2009996875', 'https://openalex.org/W2010038282', 'https://openalex.org/W2013668773', 'https://openalex.org/W2014698810', 'https://openalex.org/W2025371271', 'https://openalex.org/W2025455693', 'https://openalex.org/W2027261547', 'https://openalex.org/W2033284503', 'https://openalex.org/W2034924908', 'https://openalex.org/W2035452020', 'https://openalex.org/W2035529239', 'https://openalex.org/W2036348189', 'https://openalex.org/W2047003816', 'https://openalex.org/W2048164516', 'https://openalex.org/W2053976497', 'https://openalex.org/W2056510698', 'https://openalex.org/W2061981400', 'https://openalex.org/W2069006548', 'https://openalex.org/W2086819446', 'https://openalex.org/W2092839502', 'https://openalex.org/W2095335313', 'https://openalex.org/W2095666785', 'https://openalex.org/W2100764718', 'https://openalex.org/W2103054294', 'https://openalex.org/W2103116932', 'https://openalex.org/W2104225093', 'https://openalex.org/W2105159857', 'https://openalex.org/W2105383165', 'https://openalex.org/W2107503723', 'https://openalex.org/W2108131113', 'https://openalex.org/W2110819175', 'https://openalex.org/W2113619226', 'https://openalex.org/W2116503335', 'https://openalex.org/W2130053005', 'https://openalex.org/W2132028114', 'https://openalex.org/W2133230064', 'https://openalex.org/W2135067231', 'https://openalex.org/W2138287192', 'https://openalex.org/W2141917582', 'https://openalex.org/W2147164277', 'https://openalex.org/W2148842379', 'https://openalex.org/W2150384215', 'https://openalex.org/W2155697275', 'https://openalex.org/W2159999899', 'https://openalex.org/W2162749230', 'https://openalex.org/W2405166722', 'https://openalex.org/W2416032031', 'https://openalex.org/W2505284615', 'https://openalex.org/W25713228', 'https://openalex.org/W4252179657'], 'related_works': ['https://openalex.org/W4376112453', 'https://openalex.org/W4376112432', 'https://openalex.org/W3027934584', 'https://openalex.org/W2361331287', 'https://openalex.org/W2347803344', 'https://openalex.org/W2149769864', 'https://openalex.org/W2131965436', 'https://openalex.org/W1969696192', 'https://openalex.org/W1797702204', 'https://openalex.org/W1548867065'], 'abstract_inverted_index': {'Background:': [0], 'Umbilical': [1], 'cord': [2], 'blood': [3], '(UCB)': [4], 'is': [5, 18], 'an': [6, 91], 'easily': [7], 'accessible': [8], 'alternative': [9, 92], 'source': [10], 'for': [11, 98, 219, 230, 282], 'multipotent': [12], 'mesenchymal': [13], 'stromal': [14], 'cells': [15, 206], '(MSCs)': [16], 'and': [17, 38, 66, 119, 132, 212, 240, 287], 'generally': [19, 260], 'believed': [20], 'to': [21, 93, 242], 'provide': [22], 'MSCs': [23, 72, 77, 125, 153, 163, 184, 194, 221, 236, 275], 'with': [24, 30, 58, 74, 131, 185, 277], 'a': [25, 243, 249, 259], 'higher': [26], 'proliferative': [27, 67, 262], 'potential': [28, 68, 188, 263], 'compared': [29, 73], 'adult': [31], 'bone': [32, 75, 161], 'marrow.': [33], 'Limitations': [34], 'in': [35, 105, 113, 141, 169, 248], 'cell': [36], 'number': [37], 'strict': [39], 'dependence': [40], 'of': [41, 47, 55, 69, 143, 151, 160, 181, 202, 264, 272], 'expansion': [42, 201], 'procedures': [43], 'from': [44, 129, 158, 192, 246], 'selected': [45], 'lots': [46], 'fetal': [48, 95, 134], 'bovine': [49, 96, 135, 251], 'serum': [50, 97], 'have': [51], 'hampered': [52], 'the': [53, 64, 148, 231, 270], 'progress': [54], 'clinical': [56, 179, 244], 'applications': [57], 'UCB-derived': [59, 204], 'MSCs.': [60, 266], 'Methods:': [61], 'We': [62, 84, 228], 'analyzed': [63], 'isolation': [65], 'human': [70, 87, 235, 278], 'UCB': [71, 130, 144, 152, 193, 220, 247, 265, 274], 'marrow': [76, 162], 'under': [78, 164, 223], 'optimized': [79, 165], 'ex': [80], 'vivo': [81, 200], 'culture': [82, 166, 225], 'conditions.': [83, 226], 'further': [85], 'investigated': [86], 'platelet': [88, 279], 'lysate': [89], 'as': [90, 207, 209], 'replace': [94], 'clinical-scale': [99], 'MSC': [100, 109, 137], 'expansion.': [101], 'Clonogenicity': [102], 'was': [103, 139], 'determined': [104], 'colony-forming': [106], 'units-fibroblast': [107], 'assays.': [108, 123], 'functions': [110], 'were': [111], 'tested': [112], 'hematopoiesis': [114, 283], 'support,': [115, 284], 'vascular-like': [116, 213], 'network': [117, 214], 'formation': [118, 215], 'immune': [120, 210, 285], 'modulation': [121], 'potency': [122], 'Results:': [124], 'could': [126, 189, 216], 'be': [127, 190, 217, 238], 'propagated': [128, 222, 241, 276], 'without': [133], 'serum.': [136], 'propagation': [138], 'effective': [140], '46%': [142], 'samples.': [145], 'Once': [146], 'established,': [147], 'proliferation': [149], 'kinetics': [150], 'did': [154], 'not': [155], 'differ': [156], 'significantly': [157], 'that': [159, 234], 'conditions,': [167], 'resulting': [168], 'more': [170], 'than': [171], '50': [172], 'population': [173], 'doublings': [174], 'after': [175], '15': [176], 'weeks.': [177, 198], 'A': [178], 'quantity': [180, 245], '100': [182], 'million': [183], 'retained': [186], 'differentiation': [187], 'obtained': [191, 239], 'within': [195], 'approximately': [196], '7': [197], 'Ex': [199], 'hematopoietic': [203], 'CD34+': [205], 'well': [208], 'inhibition': [211], 'shown': [218], 'both': [224], 'Conclusion:': [227], 'demonstrate': [229], 'first': [232], 'time': [233], 'can': [237], 'completely': [250], 'serum-free': [252], 'system.': [253], 'Surprisingly,': [254], 'our': [255], 'data': [256, 268], 'argue': [257], 'against': [258], 'superior': [261], 'Functional': [267], 'indicate': [269], 'applicability': [271], 'clinical-grade': [273], 'lysate-conditioned': [280], 'medium': [281], 'regulation': [286], 'vascular': [288], 'regeneration.': [289]}, 'abstract_inverted_index_v3': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2127443288', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 14}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 13}, {'year': 2013, 'cited_by_count': 12}, {'year': 2012, 'cited_by_count': 15}], 'updated_date': '2025-01-27T09:42:07.184877', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
