Mitotic Raf-1 Is Stimulated Independently of Ras and Is Active in the Cytoplasm

Name: Work Video:
Duration: 3 min 30 s
Algirdas Ziogas; Ivo C. Lorenz; Karin Moelling; Gerald Radziwill
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4050, 4058, 4097, 4173, 4182, 4193, 4202, 4211, 4239, 4245, 4255, 4276, 4302, 4313, 4317, 4358, 4368, 4395, 4399, 4403, 4427, 4474, 4481, 4503, 4518, 4550, 4571, 4580, 4622, 4635, 4642, 4672, 4695, 4703, 4720, 4809, 4887, 4895, 4991, 5006, 5034, 5117, 5120, 5132, 5136, 5159, 5166, 5170, 5184, 5189, 5218, 5249, 5271, 5276, 5282, 5303, 5306, 5314, 5349, 5390, 5479, 5485, 5503, 5510, 5519, 5527, 5605, 5611, 5670, 5674, 5678, 5684, 5686, 5711, 5765, 5785, 5811, 5823, 5830, 5904, 5918, 6004, 6020, 6045, 6068, 6078, 6093, 6105, 6125, 6132, 6159, 6173, 6187, 6193, 6219, 6239, 6252, 6300, 6307, 6315, 6341, 6352, 6366, 6371, 6385, 6445, 6502], 'proliferation,': [12, 250, 6012], 'differentiation,': [13, 251], 'and': [14, 18, 181, 252, 256, 419, 511, 520, 634, 703, 711, 728, 802, 838, 847, 997, 1047, 1061, 1127, 1132, 1168, 1327, 1333, 1412, 1471, 1496, 1667, 1772, 1815, 1872, 1918, 1963, 1996, 2033, 2069, 2099, 2144, 2159, 2180, 2236, 2262, 2278, 2361, 2390, 2416, 2432, 2516, 2522, 2540, 2562, 2603, 2643, 2659, 2667, 2680, 2696, 2715, 2733, 2868, 2881, 2978, 3016, 3076, 3096, 3116, 3158, 3264, 3398, 3400, 3403, 3456, 3470, 3528, 3550, 3669, 3687, 3730, 3767, 3787, 3810, 3889, 3981, 3983, 3995, 4008, 4021, 4031, 4047, 4052, 4067, 4070, 4118, 4123, 4138, 4163, 4165, 4168, 4208, 4225, 4292, 4319, 4347, 4366, 4405, 4476, 4505, 4539, 4543, 4557, 4689, 4763, 4782, 4795, 4819, 4890, 4963, 5037, 5174, 5227, 5395, 5468, 5632, 5666, 5702, 5739, 5744, 5767, 5787, 5814, 5851, 6026, 6052, 6084, 6097, 6100, 6111, 6153, 6241, 6248, 6377, 6436, 6448, 6482, 6493, 6499], 'apoptosis.': [15, 253], 'Recently,': [16, 254, 784, 1494, 5725, 5908], 'we': [17, 255, 785, 1495, 1701, 2480, 2509, 3600, 5127], 'others': [19, 257, 1497], 'showed': [20, 138, 258, 376, 2896, 3109, 3672, 5451], 'not': [24, 66, 168, 207, 232, 262, 304, 406, 445, 470, 1503, 1744, 2942, 2966, 3008, 3161, 3184, 3193, 3298, 3379, 3412, 3460, 3488, 3746, 3788, 3799, 3858, 4361, 4508, 4567, 4627, 4638, 4725, 5155, 5179, 5398, 5531, 5558, 5627, 5723, 5742, 6061, 6116], 'only': [25, 263, 1504, 3194, 3784, 3821, 4470, 5392, 5718], 'activated': [26, 92, 126, 264, 330, 364, 632, 845, 1001, 1741, 1927, 2750, 3190, 3434, 3640, 3736, 3796, 4212, 4230, 4246, 4281, 4304, 4340, 4472, 4516, 4536, 4551, 4680, 4698, 4760, 4775, 4790, 4999, 5207, 5239, 5250, 5327, 5532, 5676, 5807], 'mitogenic': [28, 266, 510, 1507, 4392, 4435, 5809], 'pathways': [29, 267, 6360], 'leading': [30, 268, 1511, 6009], 'to': [31, 50, 91, 105, 150, 157, 170, 269, 288, 329, 343, 388, 395, 408, 638, 788, 854, 861, 987, 1071, 1269, 1290, 1512, 1665, 1746, 1770, 1777, 1813, 1823, 1904, 1923, 2020, 2168, 2449, 2475, 2500, 2511, 2537, 2544, 2592, 2728, 2735, 2747, 2761, 2782, 2855, 2890, 2970, 3040, 3134, 3323, 3449, 3636, 3723, 3739, 3813, 3871, 3885, 3911, 3919, 3989, 4184, 4344, 4390, 4441, 4685, 4793, 4798, 4806, 4823, 5202, 5213, 5229, 5321, 5517, 5845, 5902, 6010, 6028, 6175, 6309, 6430], 'cell': [32, 135, 270, 373, 496, 1513, 2477, 2506, 2520, 2622, 2647, 2801, 2822, 2898, 2919, 2924, 2950, 3970, 4771, 5149, 5771, 5796, 5832, 5906, 5925, 6011, 6022, 6095, 6458], 'cycle': [33, 271, 1514, 2576, 2802, 2899, 2920, 2951, 5797, 5833, 6023], 'entry': [34, 272, 1515], 'but': [35, 273, 1414, 1516, 3200, 3706, 3745, 3857, 4588, 4984, 5397, 5626, 5741], 'also': [36, 274, 1267, 1399, 1517, 3174, 3201, 3605, 3721, 4217, 4450, 4589, 4987, 5144, 5311, 5564, 5774, 6181, 6422, 6467, 6489], 'during': [37, 275, 1518, 5308, 5513, 5660, 6112, 6168], 'mitosis.': [38, 276, 6169], 'Transient': [39, 277, 2991], 'expression': [40, 278, 727, 2912, 2940, 3510, 4570, 6003, 6019, 6067], 'studies': [41, 279], 'COS': [43, 281, 6050], 'cells': [44, 194, 219, 282, 432, 457, 1236, 1510, 1598, 1658, 1970, 2029, 2041, 2061, 2132, 2403, 2596, 2632, 2683, 2693, 2792, 2817, 2833, 2840, 2851, 2864, 2895, 2904, 2956, 2960, 2964, 2977, 2981, 3057, 3092, 3178, 3280, 3296, 3448, 3566, 3618, 3679, 3965, 4006, 4054, 4091, 4155, 4205, 4216, 4262, 4372, 4379, 4428, 4461, 4512, 4529, 4546, 4565, 4585, 4600, 4623, 4663, 4675, 5330, 5357, 5384, 5457, 5499, 5535, 5542, 5568, 5624, 5733, 5804, 5813, 6051, 6054, 6137, 6200, 6247], 'now': [45, 283], 'demonstrate': [46, 190, 215, 284, 428, 453, 789, 1499, 1718, 3187, 3521, 4386, 4631], 'that,': [47, 285, 4387], 'contrast': [49, 149, 287, 387, 4389, 5212], 'growth': [51, 75, 289, 313, 486, 515, 1276, 3543, 4787, 5520, 5734, 5929, 6029, 6063, 6162, 6228], 'factor-dependent': [52, 76, 290, 314, 1114, 1277, 3544, 5521, 6163], 'activation': [53, 57, 70, 101, 164, 291, 295, 308, 339, 402, 572, 644, 752, 1057, 1115, 1184, 1278, 1334, 1508, 1601, 1708, 1721, 1730, 2788, 3170, 3204, 3287, 3329, 3341, 3360, 3383, 3418, 3458, 3493, 3504, 3538, 3554, 3611, 3700, 3709, 3741, 3751, 3818, 3854, 3875, 3950, 4238, 4312, 4367, 4393, 4398, 4634, 4641, 4671, 4702, 4808, 4967, 5131, 5183, 5216, 5235, 5257, 5275, 5348, 5478, 5484, 5491, 5512, 5614, 5619, 5701, 5710, 5764, 5789, 6351], 'Raf-1,': [55, 72, 293, 310, 795, 1060, 1068, 1180, 1280, 3385, 3777, 4396, 4727, 5030, 5185, 5233, 5528, 6322], 'mitotic': [56, 69, 98, 132, 163, 193, 218, 294, 307, 336, 370, 401, 431, 456, 1600, 1707, 1720, 1729, 1753, 1757, 2976, 3169, 3340, 3382, 3417, 3447, 3492, 3537, 3564, 3610, 3678, 3699, 3708, 3795, 3817, 3866, 3949, 3964, 4127, 4237, 4311, 4353, 4371, 4397, 4453, 4511, 4599, 4612, 4633, 4656, 4662, 5130, 5182, 5209, 5234, 5259, 5295, 5329, 5355, 5456, 5477, 5498, 5534, 5567, 5600, 5623, 5689, 6123, 6136, 6178, 6185, 6199, 6246, 6254, 6295, 6339, 6350, 6420], 'Ras-independent.': [61, 299], 'Dominant': [62, 300], 'negative': [63, 301, 995, 1417, 1818, 3349, 5063, 5172, 5176], 'RasS17N': [64, 302, 1819, 3352, 3377, 3464, 5173], 'does': [65, 167, 206, 231, 303, 405, 444, 469, 1743, 3411, 4637, 5178], 'interfere': [67, 305, 3380, 3489, 4362, 5180], 'with': [68, 306, 631, 800, 951, 1166, 1237, 1605, 1982, 2044, 2066, 2094, 2142, 2165, 2178, 2183, 2304, 2310, 2359, 2385, 2406, 2558, 2572, 2581, 2651, 2707, 2717, 2741, 2755, 2805, 2827, 2841, 2859, 2962, 3004, 3013, 3047, 3062, 3086, 3261, 3281, 3291, 3313, 3381, 3433, 3490, 3548, 3681, 3765, 4010, 4027, 4146, 4176, 4189, 4265, 4339, 4363, 4429, 4491, 4531, 4563, 4624, 4640, 4678, 5146, 5181, 5254, 5459, 6215, 6222], 'whereas': [73, 311, 3386, 4614, 5186], 'epidermal': [74, 312, 485], 'stimulation': [77, 171, 315, 409, 1134, 1233, 1747, 3390, 4251, 4275, 4621, 4789, 5158, 5188, 5810], 'inhibited.': [81, 319, 5192], 'In': [82, 161, 320, 399, 1316, 1596, 1697, 2780, 2968, 3500, 3541, 4090, 4433, 4510, 4526, 4603, 4872, 5123, 5211, 5297, 5382, 5622, 5654, 5802, 6417], 'addition,': [83, 162, 321, 400, 1317, 4604], 'the': [84, 113, 117, 146, 151, 158, 173, 182, 210, 235, 322, 351, 355, 384, 389, 396, 411, 420, 448, 473, 564, 639, 715, 791, 857, 862, 947, 988, 1048, 1056, 1064, 1161, 1176, 1275, 1401, 1416, 1464, 1659, 1698, 1704, 1749, 2009, 2016, 2279, 2283, 2302, 2311, 2321, 2440, 2444, 2450, 2484, 2487, 2493, 2513, 2523, 2531, 2541, 2545, 2670, 2742, 2749, 2763, 2769, 2775, 2784, 2796, 2800, 2811, 2821, 2877, 2894, 2949, 3041, 3048, 3070, 3100, 3128, 3135, 3314, 3324, 3335, 3344, 3347, 3366, 3373, 3425, 3440, 3453, 3475, 3483, 3491, 3502, 3542, 3567, 3615, 3629, 3645, 3704, 3718, 3756, 3805, 3837, 3860, 3881, 3886, 3912, 3915, 3920, 3957, 4003, 4022, 4032, 4095, 4106, 4109, 4126, 4135, 4142, 4147, 4185, 4199, 4229, 4234, 4242, 4286, 4298, 4329, 4391, 4417, 4434, 4446, 4471, 4486, 4495, 4500, 4643, 4686, 4716, 4799, 4876, 4882, 4888, 4898, 4992, 5001, 5124, 5194, 5224, 5244, 5262, 5269, 5273, 5280, 5298, 5301, 5315, 5441, 5482, 5504, 5524, 5538, 5606, 5635, 5682, 5778, 5795, 5812, 5818, 5827, 5831, 5846, 5896, 5905, 5916, 6005, 6021, 6042, 6046, 6057, 6076, 6079, 6108, 6191, 6223, 6236, 6253, 6301, 6312, 6327, 6332, 6364, 6372, 6392, 6441, 6456, 6479, 6503], 'mutant': [86, 119, 324, 357, 3103, 3351, 3427, 3442, 3625, 4331, 5196, 5443], 'RafR89L,': [87, 325, 3428, 5204], 'which': [88, 121, 205, 230, 326, 359, 443, 468, 569, 706, 1069, 1181, 2469, 3319, 3429, 3481, 3628, 3833, 4267, 4294, 4336, 4728, 5031, 5662, 5900, 6088, 6155, 6336, 6388], 'cannot': [89, 327, 3430, 3638, 4337, 5267, 5446], 'bind': [90, 328, 1664, 5842], 'Ras,': [93, 331, 568, 3956, 4341, 5035, 5203, 6446], 'still': [95, 333, 3150, 5206, 5722, 6115, 6379], 'stimulated': [96, 334, 1505, 2716, 4451, 4530, 5448, 6249, 6320], 'cells.': [99, 133, 337, 371, 1713, 2990, 3867, 4657, 5140, 5210, 5260, 5690], 'Mitotic': [100, 338, 2131, 6369], 'seems': [104, 342, 1268, 3722, 5693], 'be': [106, 125, 344, 363, 3639, 3724, 3792, 3814, 3843, 3872, 4609, 5112, 5326, 5447, 5630, 5658, 6073, 6172, 6306, 6319, 6346], 'partially': [107, 345], 'dependent': [108, 346, 5914], 'on': [109, 347, 1421, 2272, 2401, 2918, 3353, 3755, 3830, 4718, 4817, 4826, 5393, 5399, 5915, 6041], 'tyrosine': [110, 348, 518, 522, 561, 1173, 1226, 1286, 3568, 3603, 3632, 3642, 3692, 3719, 3757, 3773, 3789, 3807, 3831, 3848, 4784, 4884, 4893, 5038, 5304, 5466, 5470, 5505], 'phosphorylation': [111, 349, 840, 1111, 1123, 1221, 1266, 1332, 1609, 3111, 3197, 3604, 3774, 3786, 3790, 3845, 4894, 5039, 5305, 5389, 5471, 6124, 6186, 6370], 'since': [112, 350, 5839], 'activity': [115, 353, 749, 832, 1080, 1107, 1137, 1397, 1672, 2517, 2974, 3084, 3131, 3157, 3356, 3438, 3676, 3864, 4074, 4130, 4151, 4196, 4422, 4456, 4582, 4607, 4616, 5110, 5454, 5562, 5855, 5921, 6001, 6016, 6238], 'Raf': [118, 356, 2171, 2296, 2485, 2514, 3102, 3426, 3441, 3624, 3743, 4174, 4330, 5442], 'RafYY340/341FF,': [120, 358], 'can': [122, 360, 746, 797, 1164, 1169, 1329, 1663, 1668, 3572, 5111, 5325, 5629, 5680, 5708, 5736, 5793, 5841, 5894, 5923, 6072, 6098, 6213, 6318], 'no': [123, 361, 3110, 4515, 4593, 4605], 'longer': [124, 362], 'by': [127, 365, 579, 835, 839, 1000, 1110, 1224, 1932, 2135, 2155, 2254, 2264, 2287, 2300, 2308, 2421, 2456, 2599, 2635, 2686, 2803, 2834, 3045, 3069, 3363, 3423, 3462, 3509, 3641, 4039, 4077, 4462, 4761, 4776, 5000, 5114, 5163, 5449, 5634, 6075, 6321, 6375], 'Src,': [128, 366, 5036, 6449], 'reduced': [130, 368, 3071, 3133, 3508, 3674, 5453], 'Surprisingly,': [134, 372, 5523], 'fractionation': [136, 374, 3971, 5263], 'experiments': [137, 375, 2578, 3972, 5264], 'mitotic-activated': [140, 378, 3776], 'predominantly': [143, 381, 1736, 4197, 4283, 4299, 5241], 'located': [144, 382, 4284, 5242], 'cytoplasm': [147, 385, 3921], 'mitogen-activated': [152, 174, 390, 412, 478], 'bound': [156, 394, 3039], 'plasma': [159, 397, 640, 863, 3325, 3887, 4186, 4287, 4800, 5225], 'membrane.': [160, 398], 'lead': [169, 407, 1070, 1745, 4805, 5228], '(MAPKK': [178, 416], 'or': [179, 417, 2050, 2706, 2712, 2754, 2957, 4431, 5716, 5927], 'MEK)': [180, 418], 'extracellular': [183, 421, 481], 'signal-regulated': [184, 422, 482], '(ERK).': [187, 425], 'These': [188, 213, 426, 451, 4629], 'data': [189, 214, 427, 452, 1715, 3520, 4385, 4630], 'Ras-independent': [196, 221, 434, 459, 4236, 5157, 5256], 'mechanism': [197, 222, 435, 460, 1419, 1705, 2785, 3715, 4252, 5028, 5610], 'results': [198, 223, 436, 461, 570, 1118, 1182, 1733, 3167, 4406, 4560, 5142, 5236, 6017, 6382], 'cytoplasmic': [201, 226, 439, 464, 858, 1737, 2532, 3315, 3882, 3997, 4019, 4048, 4107, 4136, 4300, 4323, 4351, 4409, 5247, 5284, 6195], 'active': [202, 227, 440, 465, 1738, 3894, 3961, 4221, 4324, 4352, 4410, 4496, 4594, 5232, 5285, 5601, 6043, 6196], 'signal': [208, 233, 446, 471, 4767, 6298, 6358], 'via': [209, 234, 447, 472, 5817, 5843], 'MEK/ERK': [211, 236, 449, 474, 1750, 4644, 5607, 5788, 5819, 6302], 'pathway.': [212, 237, 450, 475, 1762, 5608, 6303], 'MAPK/ERK': [476], 'factor': [487, 516, 4788, 5763, 6229], 'glutathione': [488], 'S-transferase': [489], 'phosphate-buffered': [490], 'saline': [491], 'radioimmune': [492], 'precipitation': [493], 'buffer': [494, 2185, 2366, 3980], 'fluorescein-activated': [495], 'sorter.': [497], 'The': [498, 1043, 1714, 1763, 1804, 2250, 2292, 2318, 2466, 2526, 2621, 2630, 2646, 2678, 2935, 3035, 3300, 3436, 3623, 4018, 4044, 4478, 4959, 5168, 5438, 5508, 5560, 5609, 6103], 'key': [505, 4877], 'regulator': [506, 996, 6314], 'transmission': [508], 'developmental': [512], 'signals': [513, 4438], 'through': [514, 4439, 6394], 'receptor': [517, 560, 4994], 'kinases': [519, 523, 562, 1159, 1227, 3552, 3643, 4886, 6381], 'non-receptor': [521, 1225, 4783, 4883], '(1Moelling': [524, 4740], 'K.': [525, 686, 815, 1018, 1030, 1450, 1482, 1525, 1539, 1589, 1641, 1792, 1892, 2344, 4741, 4925, 5049, 5094, 5431, 5859, 5878], 'Heimann': [526, 4742], 'B.': [527, 4743, 5981], 'Beimling': [528, 4744], 'P.': [529, 582, 611, 651, 1342, 1379, 1529, 3215, 3925, 3927, 4745], 'Rapp': [530, 656, 1142, 1246, 1298, 4746, 4832, 4854, 4905], 'U.R.': [531, 1143, 1247, 1299, 4747, 4833, 4855, 4906], 'Sander': [532, 4748], 'T.': [533, 1012, 1377, 1547, 1886, 1934, 1942, 4749], 'Nature.': [534, 672, 3248, 4750], '1984;': [535, 4751], '312:': [536, 4752], '558-561Crossref': [537, 4753], 'PubMed': [538, 553, 597, 621, 676, 695, 779, 826, 880, 910, 940, 964, 980, 1038, 1098, 1155, 1199, 1217, 1260, 1311, 1353, 1371, 1390, 1442, 1459, 1489, 1557, 1581, 1633, 1692, 1799, 1850, 1869, 1948, 2351, 3229, 3252, 3594, 3660, 3943, 4754, 4845, 4867, 4919, 4954, 5018, 5056, 5086, 5103, 5340, 5377, 5423, 5552, 5588, 5649, 5757, 5872, 5888, 5950, 5973, 5992, 6147, 6265, 6289, 6412], 'Scopus': [539, 554, 598, 622, 677, 696, 780, 827, 881, 911, 941, 965, 981, 1039, 1099, 1200, 1261, 1312, 1354, 1372, 1391, 1443, 1460, 1490, 1558, 1582, 1634, 1693, 1800, 1851, 1949, 2352, 3230, 3253, 3595, 3661, 3944, 4755, 4868, 4920, 4955, 5057, 5087, 5104, 5341, 5378, 5424, 5553, 5589, 5650, 5758, 5873, 5889, 5951, 5974, 5993, 6148, 6266, 6290, 6413], '(149)': [540, 4756], 'Google': [541, 556, 600, 624, 664, 679, 698, 740, 782, 829, 883, 913, 943, 967, 983, 1023, 1041, 1101, 1156, 1202, 1218, 1263, 1314, 1356, 1374, 1393, 1445, 1462, 1492, 1560, 1584, 1594, 1636, 1646, 1695, 1802, 1853, 1870, 1897, 1951, 2354, 3232, 3255, 3597, 3663, 3905, 3946, 4757, 4846, 4870, 4922, 4957, 4982, 5019, 5059, 5089, 5106, 5343, 5380, 5426, 5436, 5555, 5591, 5652, 5760, 5875, 5891, 5953, 5976, 5995, 6150, 6268, 6292, 6415], 'Scholar,2Morrison': [542], 'D.K.': [543, 957, 1139, 1192, 1207, 1293, 3653, 4829, 4849], 'Cutler': [544], 'R.E.': [545], 'Curr.': [546], 'Opin.': [547], 'Cell': [548, 972, 2575], 'Biol.': [549, 900, 930, 973, 1147, 1195, 1209, 1386, 1432, 1455, 1553, 1571, 1623, 1682, 1861, 3584, 3656, 3933, 4837, 5014, 5076, 5099, 5367, 5413, 5578, 5969, 5988, 6279, 6408], '1997;': [550, 1035, 1486, 1796, 2348, 3935, 5053, 5337, 5549, 5646, 5754, 5947, 5970, 5989, 6144, 6262, 6409], '9:': [551, 5338, 5550, 5647, 5886, 6145, 6263], '174-179Crossref': [552], '(538)': [555], 'Scholar).': [557, 625, 699, 741, 783, 830, 944, 984, 1042, 1102, 1157, 1219, 1264, 1315, 1394, 1493, 1595, 1647, 1696, 1803, 1898, 1952, 2355, 3256, 3598, 3906, 3947, 4871, 4958, 5020, 5107, 5344, 5381, 5437, 5653, 5761, 5892, 5996, 6151, 6293, 6416], 'Activation': [558], 'stimulate': [563, 747, 5852, 5895], 'small': [565, 2502, 3824], 'GTP-binding': [566], 'cascade': [577], 'headed': [578], '(3Dent': [581], 'Haser': [583], 'W.': [584, 5009], 'Haystead': [585], 'T.A.': [586], 'Vincent': [587], 'L.A.': [588, 1833], 'Roberts': [589, 1300, 1339, 1546, 1836, 4856, 4942], 'T.M.': [590, 1301, 1340, 1837, 4857, 4943], 'Sturgill': [591, 1380], 'T.W.': [592, 1381], 'Science.': [593, 691], '1992;': [594, 615, 1350], '257:': [595], '1404-1407Crossref': [596], '(501)': [599], 'Scholar,': [601, 665, 680, 884, 914, 968, 1024, 1203, 1357, 1375, 1446, 1561, 1585, 1637, 3233, 4847, 4923, 5090, 5427, 5876, 5954, 5977, 6269], '4Howe': [602], 'L.R.': [603], 'Leevers': [604, 3220], 'S.J.': [605, 667, 1565, 1617, 3221, 5407], 'Gomez': [606], 'N.': [607, 1523, 1533, 6397], 'Nakielny': [608], 'S.': [609, 649, 774, 821, 920, 924, 1255, 1348, 1474, 1545, 1784, 1845, 1940, 2336, 3219, 4914, 4949, 5041, 5867, 5938], 'Cohen': [610, 650, 3214], 'Marshall': [612, 654, 670, 733, 1364, 3222, 3898, 4975], 'C.J.': [613, 671, 734, 760, 892, 928, 1365, 3223, 3899, 4976], 'Cell.': [614, 1089, 1194, 1304, 1385, 1454, 3655, 4860, 5013, 5098, 5335, 5547, 5644, 5968, 5987, 6142, 6260, 6407], '71:': [616], '335-342Abstract': [617], 'Full': [618, 877, 905, 907, 935, 937, 977, 1093, 1095, 1152, 1214, 1308, 1437, 1439, 1576, 1578, 1628, 1630, 1687, 1689, 1866, 3589, 3591, 3938, 3940, 4842, 4864, 5081, 5083, 5372, 5374, 5418, 5420, 5583, 5585, 6284, 6286], 'Text': [619, 878, 906, 908, 936, 938, 978, 1094, 1096, 1153, 1215, 1309, 1438, 1440, 1577, 1579, 1629, 1631, 1688, 1690, 1867, 3590, 3592, 3939, 3941, 4843, 4865, 5082, 5084, 5373, 5375, 5419, 5421, 5584, 5586, 6285, 6287], 'PDF': [620, 879, 909, 939, 979, 1097, 1154, 1216, 1310, 1441, 1580, 1632, 1691, 1868, 3593, 3942, 4844, 4866, 5085, 5376, 5422, 5587, 6288], '(631)': [623], 'Cytoplasmic': [626], 'inactive': [627, 859, 3316, 3883, 3916, 4501], 'directly': [629, 798, 3311, 5322], 'interacts': [630, 3312], 'Ras': [633, 846, 1002, 1326, 1422, 1470, 3310, 3338, 3350, 3527, 3546, 4231, 4256, 4404, 4781, 4791, 4962, 5007, 5137, 5738], 'thereby': [636, 3320, 6027], 'recruited': [637], 'membrane': [641, 864, 2546, 3326, 3888, 3992, 4023, 4046, 4110, 4143, 4187, 4200, 4288, 4801, 5226], 'where': [642, 3327, 4802, 4875, 5272], 'further': [643, 1702, 2037, 3328, 3406, 3740, 4578], 'steps': [645, 2426, 3330], 'take': [646, 2482, 3331, 5221], 'place': [647, 5222], '(5Traverse': [648], 'Paterson': [652, 668, 1362], 'H.': [653, 1521, 1537, 1543, 5944, 5960, 5985], 'C.': [655, 813, 1004, 1026, 1476, 1786, 1878, 2338, 5043, 5572, 5574, 5880, 6273, 6275], 'U.': [657, 773, 820, 1254, 1347, 1844, 4913, 4948, 5866, 6399], 'Grand': [658], 'R.J.': [659], 'Oncogene.': [660, 1019, 1485, 1590, 1642, 1795, 1893, 2347, 5052, 5432], '1993;': [661, 1149, 1196, 1257, 3657, 4839, 4916], '8:': [662], '3175-3181PubMed': [663], '6Leevers': [666], 'H.F.': [669, 1363], '1994;': [673, 692, 776, 874, 1211, 1945, 3249], '369:': [674], '411-414Crossref': [675], '(886)': [678], '7Stokoe': [681], 'D.': [682, 1014, 1569, 1621, 1888, 5334, 5411, 5546, 5643, 5861, 5882, 5956, 5958, 6141, 6259], 'Macdonald': [683], 'S.G.': [684], 'Cadwallader': [685], 'Symons': [687], 'M.': [688, 764, 766, 811, 1567, 1619, 1857, 3923, 5409, 5942, 5966, 6405], 'Hancock': [689], 'J.F.': [690], '264:': [693], '1463-1467Crossref': [694], '(847)': [697], 'Activated': [700, 3309], 'phosphorylates': [702], 'stimulates': [704, 6331], 'MEK1': [705, 4606, 4615, 5625], 'turn': [708], 'activates': [709, 4268], 'ERK1': [710, 4475, 4504], 'ERK2,': [712], 'members': [713], 'family': [716, 949, 1163, 3647, 5317], 'MAP': [718], 'kinases.': [719, 4785], 'ERKs': [720, 754], 'are': [721, 1288, 3534, 3634, 3850, 4881, 4986, 5319, 5603, 5781, 5790, 6156, 6165, 6361, 6428], 'gene': [726, 5824], 'biosynthesis': [730], '(8Marais': [731, 3896, 4973], 'R.': [732, 888, 1359, 1915, 3897, 4974], 'Cancer': [735, 3900, 4977], 'Surv.': [736, 3901, 4978], '1996;': [737, 902, 974, 1020, 1090, 1387, 1591, 1643, 1684, 1894, 3586, 3902, 4951, 4979, 5015, 5369, 5433, 5580, 6281], '27:': [738, 3903, 4980], '101-125PubMed': [739, 3904, 4981], 'Under': [742], 'certain': [743], 'conditions': [744, 4592, 6211], 'AP-1': [748], 'without': [750, 2051, 2705, 4253], 'measurable': [751], '(9Westwick': [755], 'J.K.': [756, 886, 918, 1426, 5070], 'Cox': [757], 'A.D.': [758, 1424, 1563, 1615, 4939, 5068, 5332, 5405, 5544, 5641, 6139, 6257], 'Der': [759, 891, 927], 'Cobb': [761], 'M.H.': [762], 'Hibi': [763], 'Karin': [765], 'Brenner': [767], 'D.A.': [768], 'Proc': [769], 'Natl': [770], 'Acad': [771], 'Sci': [772], 'A.': [775, 822, 970, 1016, 1256, 1349, 1478, 1531, 1788, 1830, 1846, 1859, 1890, 2340, 3217, 3239, 4915, 4950, 5045, 5868, 5979], '91:': [777], '6030-6034Crossref': [778], '(168)': [781], 'were': [786, 1825, 1873, 1971, 2000, 2030, 2042, 2062, 2133, 2163, 2174, 2270, 2276, 2357, 2404, 2419, 2447, 2556, 2564, 2579, 2597, 2619, 2633, 2684, 2694, 2703, 2713, 2723, 2739, 2772, 2793, 3021, 3173, 3210, 3781, 3973, 3976, 4012, 4025, 4263, 4561, 4676, 5143, 6089], 'able': [787, 5320], 'avian': [792], 'homologue': [793], 'c-Mil,': [796], 'interact': [799, 950, 1165, 3432, 4338, 6099, 6214], 'c-Jun': [801, 804], 'phosphorylate': [803, 1170, 5323], 'independently': [805, 5005, 6299], 'MAPKs': [807], '(10Radziwill': [808], 'G.': [809, 1006, 1028, 1141, 1484, 1535, 1794, 1880, 2346, 4831, 5051, 6403], 'Niehof': [810], 'Rommel': [812, 1475, 1785, 2337, 5042], 'Moelling': [814, 1017, 1029, 1481, 1588, 1640, 1791, 1891, 2343, 5048, 5430], 'Proc.': [816, 1250, 1343, 1840, 4909, 4944, 5862], 'Natl.': [817, 1251, 1344, 1841, 4910, 4945, 5863], 'Acad.': [818, 1252, 1345, 1842, 4911, 4946, 5864], 'Sci.': [819, 873, 1253, 1346, 1843, 4912, 4947, 5865], '1995;': [823, 932, 961, 1368, 1434, 1456, 1573, 1625, 3226, 5078, 5100, 5415, 5869, 5885], '92:': [824, 5870], '1421-1425Crossref': [825], '(18)': [828], 'regulated': [834, 1109], 'protein-protein': [836, 1104], 'interactions': [837, 1105], 'events.': [841, 1112], 'Direct': [842], 'interaction': [843, 1044, 3410, 3525], 'between': [844, 1045, 3526, 4961, 5700], 'two': [848, 1171, 2064, 2422, 3630, 3691, 3806, 5465], 'N-terminal': [849], 'regions': [850, 953], 'leads': [853, 3910, 5901], 'translocation': [855, 3879, 4181], '(11Avruch': [865], 'J.': [866, 899, 929, 1008, 1010, 1146, 1208, 1367, 1431, 1480, 1570, 1587, 1622, 1639, 1681, 1790, 1855, 1860, 1882, 1884, 1938, 1944, 2342, 3583, 3932, 4836, 5047, 5075, 5366, 5412, 5429, 5577, 5753, 6278], 'Zhang': [867], 'X.F.': [868], 'Kyriakis': [869], 'J.M.': [870], 'Trends': [871, 971], 'Biochem.': [872], '19:': [875], '279-283Abstract': [876], '(542)': [882], '12Drugan': [885], 'Khosravi-Far': [887], 'White': [889], 'M.A.': [890, 5751], 'Sung': [893], 'Y.-J.': [894], 'Hwang': [895], 'Y.-W.': [896], 'Campbell': [897], 'S.L.': [898], 'Chem.': [901, 931, 1148, 1210, 1433, 1572, 1624, 1683, 1862, 3585, 3934, 4838, 5077, 5368, 5414, 5579, 6280], '271:': [903, 1685, 3587, 5370, 5581, 6282], '233-237Abstract': [904], '(131)': [912], '13Brtva': [915], 'T.R.': [916], 'Drugan': [917], 'Ghosh': [919], 'Terrell': [921], 'R.S.': [922, 4935], 'Campbell-Burk': [923], 'Bell': [925], 'R.M.': [926], '270:': [933, 1435, 1574, 1626, 5079, 5416], '9809-9812Abstract': [934], '(193)': [942], 'Proteins': [945, 2269], '14-3-3': [948, 985, 1046, 5844], 'different': [952, 3374, 4487, 5800, 6217], '(14Morrison': [956], 'Mol.': [958, 1193, 1384, 1453, 3654, 5012, 5097, 5967, 5986, 6406], 'Reprod.': [959], 'Dev.': [960, 1034, 5884, 5946], '42:': [962], '507-514Crossref': [963], '(62)': [966], '15Aitken': [969], '6:': [975], '341-347Abstract': [976], '(349)': [982], 'binds': [986, 4792], 'N': [989, 3476], 'terminus': [990, 1050, 1066, 1178, 3477], 'as': [993, 1240, 2327, 2393, 2882, 2884, 3027, 3067, 3106, 3119, 3121, 3268, 4084, 4373, 4375, 4489, 4497, 4499, 4705, 4707, 4732, 4780, 5536, 6201, 6324], 'displaced': [999], '(16Rommel': [1003, 1877], 'Radziwill': [1005, 1027, 1483, 1793, 1879, 2345, 5050], 'Lovric': [1007, 1479, 1789, 1881, 2341, 5046], 'Noeldeke': [1009, 1883], 'Heinicke': [1011, 1885], 'Jones': [1013, 1887], 'Aitken': [1015, 1889], '12:': [1021, 1592, 1644, 1895, 5434], '609-619PubMed': [1022, 1896], '17Rommel': [1025], 'Hafen': [1031], 'E.': [1032, 5962, 5964], 'Mech.': [1033], '64:': [1036], '95-104Crossref': [1037], '(40)': [1040], 'C': [1049, 1065, 1177], 'independent': [1054, 1468, 1725, 3716, 3954, 4316, 4402, 5033, 5135, 5502, 5604], 'status': [1058], 'mutations': [1062], 'at': [1063, 1125, 1175, 1611, 1993, 2247, 2569, 2627, 2672, 2996, 4285, 5223, 5799, 5931, 6037, 6107, 6326], 'loss': [1072], 'binding': [1074, 5200], '14-3-3,': [1076], 'abolish': [1077], 'its': [1078, 1670, 3082, 3203, 5199, 5255, 5853, 5919, 6386], '(18Muslin': [1081], 'A.J.': [1082, 3237], 'Tanner': [1083], 'J.W.': [1084], 'Allen': [1085], 'P.M.': [1086, 5011], 'Shaw': [1087], 'A.S.': [1088], '84:': [1091], '889-897Abstract': [1092], '(1195)': [1100], 'Besides': [1103], 'Growth': [1113, 4811, 5762], 'an': [1120, 1271, 1606, 2025, 2848, 2916, 2995, 3143, 4028, 4280, 4465, 4492, 4572, 4733, 5115, 5238, 5489, 6463], 'increase': [1121, 1607, 1669, 3080, 4192, 4418, 4579], 'mainly': [1124, 1610, 4815], 'Ser': [1126, 1612, 4818, 5394], 'Thr': [1128, 4820, 5396], 'residues': [1129, 1174, 1287, 1613, 3633, 3693, 3720, 3758, 3808, 3849, 5467, 5506], '(19Morrison': [1138, 4828], 'Heidecker': [1140, 4830], 'Copeland': [1144, 4834], 'T.D.': [1145, 4835], '268:': [1150, 4840], '17309-17316Abstract': [1151, 4841], 'Tyrosine': [1158, 1220, 1265], 'Src': [1162, 1328, 1472, 1928, 3549, 3646, 3737, 4889, 4964, 5316, 5450], 'neighboring': [1172, 3631], '(20Fabian': [1187, 3648], 'J.R.': [1188, 3649], 'Daar': [1189, 3650], 'I.O.': [1190, 3651], 'Morrison': [1191, 1206, 3652], '13:': [1197, 1946, 3658], '7170-7179Crossref': [1198, 3659], '(304)': [1201, 3662], '21Cleghon': [1204], 'V.': [1205], '269:': [1212], '17749-17755Abstract': [1213], 'major': [1230, 4899], 'event': [1231, 4900], 'T': [1235, 1657, 3565, 5356, 6082, 6086], 'cytokines': [1238], 'such': [1239, 4779, 6323], 'interleukin-2': [1241], '(22Turner': [1242, 4901], 'B.C.': [1243, 4902], 'Tonks': [1244, 4903], 'N.K.': [1245, 4904, 4927], 'Reed': [1248, 4907], 'J.C.': [1249, 4908], '90:': [1258, 4917], '5544-5548Crossref': [1259, 4918], '(39)': [1262, 4921], 'play': [1270, 3413, 3695, 5473, 5836, 6424], 'essential': [1272, 3851, 4969, 6390], 'role': [1273, 3336, 3415, 3608, 3697, 5302, 5475, 5838], 'although': [1281, 3804], 'this': [1283, 1599, 2497, 3276, 3457, 3621, 4714, 5776, 6184, 6204, 6418], 'case': [1284, 4715, 5539], 'phosphorylated': [1285, 3829, 4816, 5631], 'difficult': [1289], 'detect': [1291, 2748, 2762, 3772], '(23Morrison': [1292], 'Kaplan': [1294, 4850], 'D.R.': [1295, 3213, 4851], 'Escobedo': [1296, 4852], 'J.A.': [1297, 3241, 4853], 'Williams': [1302, 1522, 3246, 4858], 'L.T.': [1303, 3247, 4859], '1989;': [1305, 4861], '58:': [1306, 4862], '649-657Abstract': [1307, 4863], '(289)': [1313, 4869], 'it': [1318, 1649, 3387, 3558, 4797, 5692, 5726, 5840, 5909], 'has': [1319, 1650, 2331, 2915, 3559, 5351, 5401, 5727, 5910, 6119, 6232], 'been': [1320, 1651, 1780, 2332, 3560, 5352, 5402, 5728, 5911, 6120, 6233], 'shown': [1321, 1652, 4413, 5162, 5353, 5729, 5912, 6202, 6234], 'oncogenic': [1323, 1808, 4177, 4687, 4734, 6069], 'forms': [1324, 2751, 4473, 4502], 'synergize': [1330], '(24Williams': [1337], 'N.G.': [1338], 'Li': [1341, 1528], '89:': [1351], '2922-2926Crossref': [1352], '(124)': [1355], '25Marais': [1358], 'Light': [1360], 'Y.': [1361], 'EMBO': [1366, 1943, 5752], '14:': [1369], '3136-3145Crossref': [1370], '(528)': [1373], '26Jelinek': [1376], 'Dent': [1378], 'Weber': [1382], 'M.J.': [1383], '16:': [1388, 5016, 5755], '1027-1034Crossref': [1389], '(123)': [1392], 'under': [1400, 2929, 3163, 4590, 6209, 6462], 'control': [1402, 2808, 3108, 3139], 'feedback': [1404, 1418, 5027, 5064], 'mechanisms.': [1405], 'Feedback': [1406], 'involves': [1410], 'MEK': [1411, 1910, 3199, 4440, 4654, 5613, 5715, 5743, 5766], 'ERK,': [1413, 4673], 'while': [1415, 5061], 'depends': [1420, 3754, 6036], '(27Cherniack': [1423, 5067], 'Klarlund': [1425, 5069], 'Conway': [1427, 5071], 'B.R.': [1428, 5072], 'Czech': [1429, 5073], 'M.P.': [1430, 5074], '1485-1488Abstract': [1436, 5080], '(103)': [1444, 5088], '28Waters': [1447, 5091], 'S.B.': [1448, 5092], 'Yamauchi': [1449, 5093], 'Pessin': [1451, 5095], 'J.E.': [1452, 5096], '15:': [1457, 1487, 1797, 2349, 5054, 5101], '2791-2799Crossref': [1458, 5102], '(106)': [1461, 5105], 'Scholar)': [1463, 1871, 3664, 5556, 5592], 'positive': [1465, 5026, 6313], 'one': [1466], '(29Zimmermann': [1473, 1783, 2335, 5040], 'Ziogas': [1477, 1787, 2339, 5044], '1503-1511Crossref': [1488, 1798, 2350, 5055], '(29)': [1491, 1801, 2353, 5058], 'could': [1498, 3791, 4608, 6345], 'upon': [1506, 4248, 5808], 'mitosis': [1519, 5309, 5514, 5661, 6113, 6395], '(30Mamon': [1520], 'Wood': [1524], 'Frazier': [1526], 'A.L.': [1527], 'Zmuidzinas': [1530], 'Kremer': [1532], "D'Acangelo": [1534], 'Qi': [1536], 'Smith': [1538], 'Feig': [1540], 'L.': [1541, 1916, 6434], 'Piwnica-Worms': [1542], 'Halegoua': [1544], 'Cold': [1548], 'Spring': [1549], 'Harbor': [1550], 'Symp.': [1551], 'Quant.': [1552], '1991;': [1554], '56:': [1555], '251-263Crossref': [1556], '(5)': [1559], '31Laird': [1562], 'Taylor': [1564, 1616, 5406], 'Oberst': [1566, 1618, 5408], 'Shalloway': [1568, 1620, 5333, 5410, 5545, 5642, 6140, 6258], '26742-26745Abstract': [1575, 1627, 5417], '(43)': [1583, 1635, 5425], '32Lovric': [1586, 1638, 5428], '1109-1116PubMed': [1593, 1645, 5435], 'fibroblast': [1597, 1712, 5383], 'correlates': [1604], '(31Laird': [1614, 5404], 'Moreover,': [1648, 1740], 'mitotically': [1655, 2815, 2958, 3189, 4303], 'arrested': [1656, 2794, 2816, 2959], 'Src-like': [1660, 3551, 5002], 'Lck': [1662, 3571, 5004], '(33Pathan': [1673, 3575, 5358], 'N.I.': [1674, 3576, 5359], 'Ashendel': [1675, 3577, 5360], 'C.L.': [1676, 3578, 5361], 'Geahlen': [1677, 3579, 5362], 'R.L.': [1678, 3580, 5363], 'Harrison': [1679, 3581, 5364], 'M.L.': [1680, 3582, 5365], '30315-30317Abstract': [1686, 3588, 5371], '(26)': [1694, 3596, 5379], 'present': [1699, 3371, 5125, 5299, 6058], 'study': [1700, 3334, 5126, 5300, 6059, 6205], 'analyzed': [1703, 2685, 4458], 'presented': [1716], 'here': [1717, 5266], 'Ras.': [1727, 3308, 3435], 'Furthermore,': [1728, 3472, 5193], 'Raf-1.': [1739, 3540, 3702, 4240, 4411, 4810, 5296, 5480], 'pathway': [1751, 3545, 4436, 4448, 5820], 'cells,': [1754, 3140, 4454, 4613, 4710], 'indicating': [1755, 4711], 'uses': [1759], 'another': [1760], 'signaling': [1761], 'plasmids': [1764], 'pcDNA3FLAG-Rafwt,': [1765], 'pcDNA3FLAG-RafR89L': [1766], '(exchange': [1767, 1774, 1810, 1820, 1901, 1920], 'Arg89': [1769], 'Leu)': [1771], 'pcDNA3FLAG-RafYY340/341FF': [1773], 'Tyr340/341': [1776], 'Phe)': [1778, 1924], 'have': [1779, 5022], 'described': [1781, 2333, 2394, 5024], 'recently': [1782, 5023], 'cDNAs': [1805, 6442], 'coding': [1806, 1906, 1925], 'for': [1807, 1816, 1907, 1926, 2035, 2056, 2244, 2329, 2398, 2429, 2436, 2463, 2483, 2566, 2675, 2688, 2698, 2709, 2843, 3168, 3272, 3365, 3852, 3859, 3874, 4879, 4965, 5029, 5198, 5294, 5493, 5705, 5714, 6091, 6391, 6439, 6455, 6471, 6476, 6485, 6496], 'RasG12V': [1809, 4178, 4213, 4359], 'Glu12': [1812], 'Val)': [1814], 'dominant': [1817, 3348, 5171, 5175], 'Ser17': [1822], 'Asn)': [1824], 'gift': [1827], 'from': [1828, 1913, 1959, 1967, 2138, 2492, 2820, 3294, 4005, 4297, 5617], 'Dr.': [1829, 1914, 1933], 'Wittinghofer': [1831, 1858], '(34Feig': [1832], 'Pan': [1834], 'B.T.': [1835], 'Cooper': [1838], 'G.M.': [1839], '1986;': [1847], '83:': [1848], '4607-4611Crossref': [1849], '(96)': [1852], 'Scholar,35John': [1854], 'Frech': [1856], '1988;': [1863], '263:': [1864], '11792-11799Abstract': [1865], 'subcloned': [1874], 'into': [1875, 2282], 'pCis2': [1876], 'pGEX-MEK': [1899], 'K97A': [1900, 2325], 'Lys97': [1903], 'Ala)': [1905], 'kinase-inactive': [1909, 2241, 2323], 'was': [1911, 1929, 1957, 2018, 2153, 2214, 2252, 2285, 2298, 2535, 2549, 2624, 2649, 2825, 2933, 2986, 3011, 3043, 3132, 3149, 3259, 3357, 3361, 3421, 3444, 3459, 3507, 3953, 3966, 3987, 4037, 4075, 4100, 4131, 4257, 4326, 4423, 4449, 4457, 4483, 4520, 4534, 4553, 4596, 4617, 4722, 4729, 5310], 'obtained': [1912, 1958, 2471, 3175, 3293, 3422, 4327, 4562, 5145, 6226], 'Erikson': [1917], 'pSLX-SrcY527F': [1919], 'Tyr527': [1922], 'kindly': [1930], 'supplied': [1931], 'Hunter': [1935, 1941, 6438], '(36den': [1936], 'Hertog': [1937], 'Tracy': [1939], '3020-3032Crossref': [1947], '(160)': [1950], 'Anti-FLAG': [1953], 'monoclonal': [1954], 'antibody': [1955, 1966, 2167, 2306, 3042, 3050, 4467, 4493], 'M2': [1956], 'Eastman': [1960], 'Kodak': [1961], 'Co.': [1962], 'anti-active': [1964], 'ERK': [1965, 2745, 2753, 2770, 4455, 4466, 4482, 4519, 4533, 4552, 4581, 4595, 4704, 4721, 5561, 5687, 5717, 5745, 5768], 'Promega.': [1968], 'COS7': [1969, 2791, 2989, 3617, 4261, 4674, 5139], 'cultured': [1972], "Dulbecco's": [1974], 'modified': [1975], "Eagle's": [1976], 'medium': [1977, 2017, 2891], '(Life': [1978, 2005], 'Technologies,': [1979, 2006], 'Inc.)': [1980, 2007], 'supplemented': [1981, 2384], '10%': [1983], 'fetal': [1984], 'calf': [1985], 'serum,': [1986], '100': [1987, 1990, 2652, 2660, 2718], 'units/ml': [1988, 2118], 'penicillin,': [1989], 'mg/ml': [1991], 'streptomycin': [1992], '37': [1994, 2673], '°C': [1995, 2571, 2674], '5%': [1997], 'CO2.': [1998], 'Cells': [1999, 2356, 2722, 3975], 'transiently': [2001], 'transfected': [2002, 4677], 'using': [2003, 2774, 3023, 3176, 3424, 4082, 4328, 4464], 'LipofectAMINETM': [2004], 'following': [2008], "manufacturer's": [2010], 'protocol.': [2011], '8–10': [2012], 'h': [2013, 2028, 2568, 2711, 2845, 2886, 3123], 'after': [2014, 2472, 2887, 3124, 4425, 4620, 6065, 6227, 6250], 'transfection': [2015, 2992], 'changed': [2019, 3635], 'normal': [2021], 'cultivation': [2022], 'medium.': [2023], 'After': [2024, 2396, 2439], 'additional': [2026, 4803, 5490], '12': [2027], 'split': [2031, 2695], '1:3': [2032], 'incubated': [2034, 2164, 2625, 2668, 2697, 3260], '8': [2038, 2699], 'h.': [2039, 2058, 2700], 'Then': [2040, 2701], 'treated': [2043, 2704, 4009, 4264], '0.1': [2045, 2203], 'μg/ml': [2046, 2103, 2106], 'nocodazole': [2047, 2052, 2708, 2842, 2872, 2893, 3063, 3127, 3282, 4011, 4430], '(mitotic': [2048], 'cells)': [2049, 2055], '(exponentially': [2053], 'growing': [2054, 2060, 2831, 2863, 2903, 2955, 2980, 3090, 4154, 4204, 4378, 4545], '16': [2057, 2710, 2844], 'Exponentially': [2059], 'washed': [2063, 2141, 2175, 2358], 'times': [2065, 2177, 2182, 4103], 'ice-cold': [2067, 2613], 'PBS': [2068, 2360, 2617], 'lysed': [2070, 2145, 2362, 2724, 3977], 'RIPA': [2072, 2151, 2179, 2539], '(10%': [2073], 'glycerol,': [2074], '20': [2075, 2115, 2206, 2245], 'mm': [2076, 2092, 2109, 2112, 2122, 2125, 2129, 2187, 2192, 2195, 2198, 2201, 2204, 2209, 2368, 2373, 2376, 2379, 2382], 'Tris-HCl,': [2077], 'pH': [2078, 2189, 2370], '7.5,': [2079], '137': [2080], 'mmNaCl,': [2081], '0.1%': [2082], 'SDS,': [2083], '0.5%': [2084], 'deoxycholate,': [2085], '1%': [2086], 'Triton': [2087], 'X-100,': [2088], '2': [2089, 2197, 2567, 2610, 2885, 3402, 3686, 3764, 4069, 4117, 4162, 4416], 'mmEDTA,': [2090], '1': [2091, 2108, 2111, 2124, 2208, 2237, 2378, 2593, 2906, 3095, 3122, 4122, 4167, 4556], 'dithiothreitol)': [2093], 'mixture': [2096, 2387], 'protease': [2098, 2391], 'phosphatase': [2100, 2389, 5849, 5854], 'inhibitors': [2101, 2392], '(10': [2102, 2367], 'leupeptin,': [2104], '10': [2105, 2225, 2229, 2372, 2430, 2437], 'pepstatin,': [2107], 'benzamidine,': [2110], 'phenylmethylsulfonyl': [2113, 2210], 'fluoride,': [2114], 'kallikrein': [2116], 'inhibitor': [2117, 6024], 'Trasylol': [2119], '(Bayer),': [2120], '50': [2121, 2128, 2191, 2222], 'NaF,': [2123], 'sodium': [2126], 'orthovanadate,': [2127], 'β-glycerophosphate).': [2130], 'collected': [2134], 'gentle': [2136], 'shake-off': [2137], 'nocodazole-treated': [2139, 4051, 4215, 4460, 4709], 'plates,': [2140], 'PBS,': [2143, 2642], 'RIPA.': [2147, 2553], 'Protein': [2148, 4000], 'concentration': [2149], 'lysates': [2152, 4004], 'determined': [2154, 3362, 4076], 'Bradford': [2156], 'assay': [2157, 2213, 3277, 4081], '(Bio-Rad),': [2158], 'equal': [2160], 'amounts': [2162, 4001, 4057], 'anti-FLAG': [2166, 2305, 2573], 'immunoprecipitate': [2169], 'FLAG-tagged': [2170, 2983], 'proteins.': [2172], 'Immunoprecipitates': [2173], 'seven': [2176], 'three': [2181, 4102], '(50': [2186], 'Tris,': [2188, 2369], '7.4,': [2190, 2371], 'NaCl,': [2193, 2374], '5': [2194, 2375, 2589, 3668, 3729, 4207], 'MnCl2,': [2196], 'dithiothreitol,': [2199, 2380], '25': [2200], 'β-glycerophosphate,': [2202], 'Na3VO4,': [2205], 'mmNaF,': [2207], 'fluoride).': [2211], 'Kinase': [2212], 'performed': [2215, 2565, 2580, 3022, 3211, 3988, 5265], 'total': [2218, 2588, 2764, 4479], 'reaction': [2219, 2251], 'volume': [2220], 'μl': [2223, 2607, 2640, 2653, 2661], 'containing': [2224], 'μm': [2226], 'nonradiolabeled': [2227], 'ATP,': [2228], 'μCi': [2230], '[γ-32P]ATP': [2232], '(Amersham': [2233, 2315], 'Pharmacia': [2234, 2316], 'Biotech)': [2235], 'μg': [2238], 'recombinant': [2240, 2322, 3024], 'GST-MEK': [2242, 2324, 3026, 3113, 3263, 4083], 'K97R': [2243], 'min': [2246, 2400, 2431], '30': [2248, 2399, 2464, 2676], '°C.': [2249, 2629], 'stopped': [2253], 'addition': [2255, 4822, 5655], '4×': [2257], 'SDS': [2258], 'sample': [2259], 'buffer,': [2260], 'boiled,': [2261], 'resolved': [2263], 'SDS-polyacrylamide': [2265, 2729], 'gel': [2266, 2730], 'electrophoresis': [2267, 2731], '(8%).': [2268], 'blotted': [2271, 2734], 'nitrocellulose': [2273, 2736], 'membranes': [2274, 2303, 2521], 'dried,': [2277], 'radioactivity': [2280], 'incorporated': [2281], 'substrate': [2284, 2328, 3030, 3270, 4085, 5526], 'evaluated': [2286], 'PhosphorImager': [2289], '(Molecular': [2290], 'Dynamics).': [2291], 'amount': [2293, 2452, 2489, 2515, 2765, 3036, 3367, 4033, 4096, 4480], 'immunoprecipitated': [2295, 3012, 4026, 4035], 'proteins': [2297, 2771], 'compared': [2299, 2826, 2858, 2961, 3003, 3085, 3290, 3680, 4145, 5458, 6221], 'probing': [2301], 'followed': [2307, 2455], 'detection': [2309, 2313, 2777, 3838], 'ECL': [2312, 2776], 'system': [2314, 2778, 5777], 'Biotech).': [2317], 'purification': [2319], 'used': [2326, 3105, 3619, 5385, 6055, 6090], 'elsewhere': [2334], 'hypotonic': [2364, 3979], 'lysis': [2365], 'MgCl2,': [2377], '0.2': [2381], 'EDTA)': [2383], 'above.': [2395], 'incubation': [2397], 'ice': [2402], 'homogenized': [2405], '80': [2407], 'strokes': [2408], 'tight': [2411], 'fitting': [2412], 'Dounce': [2413], 'homogenizer.': [2414], 'Nuclei': [2415], 'cellular': [2417, 3958, 4243, 4364], 'debris': [2418], 'removed': [2420], 'low': [2423, 2600, 3982, 4548, 5998], 'speed': [2424, 2458, 2528, 2601, 3985, 4016], 'centrifugation': [2425, 2442, 2459, 2602, 3986], '(1200': [2427], '×g': [2428], '5000': [2433], '×': [2434, 2461, 2590, 2594], 'g': [2435, 2462], 'min).': [2438, 2465], 'second': [2441], 'step,': [2443], 'post-nuclear': [2445], 'supernatants': [2446], 'adjusted': [2448, 2536], 'same': [2451, 2488], 'high': [2457, 2527, 3984, 4015, 6013], '(100,000': [2460], 'P100': [2467, 2548], 'fraction,': [2468], 'ultracentrifugation,': [2473], 'corresponds': [2474], 'whole': [2476, 2505, 2519, 2524], 'membranes.': [2478], 'If': [2479], 'would': [2481, 2498, 3842, 6171, 6305], 'immunoprecipitation': [2486], 'cytosolic': [2494], 'fraction': [2495, 2533, 2547, 3993, 3998, 4020, 4024, 4111, 4137, 4144, 4201], 'S100': [2496, 2534], 'correspond': [2499], 'part': [2503, 6040], 'cytosol.': [2507, 2525], 'Therefore,': [2508, 3689, 5595, 5691, 6294], 'decided': [2510], 'measure': [2512], 'supernatant': [2529], 'representing': [2530], '1×': [2538, 2552], 'pellet': [2542], 'corresponding': [2543, 4045, 4148, 4684], 'resuspended': [2550, 2604, 2637], 'Both': [2554], 'fractions': [2555, 4049], 'precleared': [2557], 'G-Sepharose': [2560], 'beads,': [2561], 'immunoprecipitations': [2563], '4': [2570, 2628, 3766, 4119, 4164], 'antibody.': [2574], 'distribution': [2577, 2900, 2952, 4365], 'FACSCalibur': [2582], 'flow': [2583, 2835], 'cytometer': [2584], '(Becton': [2585], 'Dickinson).': [2586], 'A': [2587, 2656, 3405], '105': [2591], '106': [2595], 'pelleted': [2598], '200': [2606], 'PBS.': [2609], 'ml': [2611], '70%': [2614], 'ethanol,': [2615], '30%': [2616], 'solution': [2618], 'added.': [2620], 'suspension': [2623, 2648], 'overnight': [2626], 'fixed': [2631], 'harvested': [2634], 'centrifugation,': [2636], '800': [2639], 'checked': [2644], 'microscopically.': [2645], 'mixed': [2650], 'RNase': [2655], '(1': [2657], 'mg/ml)': [2658], 'propidium': [2663, 2681], 'iodide': [2664], '(400': [2665], 'μg/ml),': [2666], 'dark': [2671], 'min.': [2677], 'ethanol-fixed': [2679], 'iodide-stained': [2682], 'FACS': [2687, 6480], 'their': [2689], 'DNA': [2690, 2812], 'content.': [2691], 'Transfected': [2692], 'they': [2702], 'serum-starved': [2714], 'ng/ml': [2719], 'EGF': [2720, 4625], '(Sigma).': [2721], 'RIPA,': [2726], 'subjected': [2727], '(10%),': [2732], 'filters.': [2737], 'Filters': [2738], 'probed': [2740], 'antibodies': [2743], 'anti-ACTIVE': [2744], '(Promega)': [2746], 'anti-ERK': [2756], 'C-14': [2757], '(Santa': [2758], 'Cruz': [2759], 'Biotechnology)': [2760], 'ERK.': [2767, 4442], 'Then,': [2768], 'visualized': [2773], '(Amersham).': [2779], 'order': [2781, 2969], 'analyze': [2783], 'mitosis,': [2790, 6316], 'G2/M': [2797, 2853, 2879, 6109], 'phase': [2798, 2854], 'treatment': [2804, 3278, 4426], 'nocodazole.': [2806], 'For': [2807, 3968, 4259], 'synchronization': [2810], 'content': [2813], 'detach': [2819], 'culture': [2823], 'dish': [2824], 'exponentially': [2830, 2862, 2902, 2954, 2979, 3089, 4153, 4203, 4377, 4544], 'untreated': [2832, 3091, 3138, 4007, 4053], 'cytometry': [2836], 'analysis.': [2837], 'Treatment': [2838, 3055], 'resulted': [2846, 2873, 2993, 3064, 3283, 4179, 4218, 4278, 4320, 4348, 4575, 4700], 'enrichment': [2849], 'approximately': [2856], '90%': [2857], '15%': [2860], '(Fig.': [2865, 2905, 3031, 3051, 3093, 3393, 3465, 3496, 3513, 3665, 3684, 3726, 3760, 4041, 4086, 4112, 4156, 4522, 5593], '1,': [2866], 'b).': [2869], 'Removal': [2870], 'release': [2875], 'reversible': [2878], 'block,': [2880], 'early': [2883, 3120], 'change': [2889], 'lacking': [2892], 'd).': [2907], 'To': [2908, 3186, 3333, 3771, 4443, 4658], 'test': [2909, 4444, 4659], 'whether': [2910, 3602, 4445, 4660, 6177, 6311], 'ectopic': [2911, 6066], 'effect': [2917, 3345, 4717, 5683], 'distribution,': [2921], 'Rat-1': [2923, 3177, 5148, 6053, 6457], 'line': [2925, 5150, 6459], 'expresses': [2927], 'tetracycline-inducible': [2931], 'promoter': [2932], 'analyzed.': [2934, 3358, 4258, 5312], 'induction': [2936], 'wild-type': [2939, 3060, 3262, 3455, 3683, 3744, 4094, 4175, 4346, 5461], 'did': [2941, 3160, 3192, 3378, 3487, 4360, 6060], 'result': [2943, 3195, 3890], 'significant': [2946, 3707], 'difference': [2947], 'uninduced': [2963], '(data': [2965, 3007, 3183, 3297, 3798, 4507, 4566, 4626, 4724, 5154, 5557], 'shown).': [2967, 3009, 3185, 3299, 3800, 4509, 4568, 4628, 4726, 5156, 5559], 'compare': [2971, 3395, 3762, 4160], 'expressed': [2987, 3181], 'least': [2997, 6038], '10-fold': [2999], 'overexpression': [3000, 4254, 5673], 'FLAG-Raf-1': [3002], 'endogenous': [3005], 'αFLAG': [3014, 3049, 4029], 'antibody,': [3015, 4030], 'vitro': [3018, 4079], 'assays': [3020, 3209], 'kinase-defective': [3025, 3101, 3265], 'Raf-specific': [3029], '2,': [3032, 3052], 'upper': [3033, 4088, 4158], 'panel).': [3034, 3054, 4043, 4089], 'controlled': [3044, 4490], 'immunoblotting': [3046, 4040, 4463], 'middle': [3053], 'expressing': [3058, 5152, 6460], '(Rafwt)': [3061], 'hyperphosphorylation': [3066, 3159], 'indicated': [3068], 'electrophoretic': [3072, 3144], 'mobility': [3073, 3145], '6-fold': [3079, 4139], '2,lanes': [3094], '2).': [3097], 'As': [3098, 3732, 4170, 4412], 'expected': [3099, 3733, 4171], 'RafK375E': [3104], '(lanes': [3114, 4206, 4223, 4380, 4555], '3': [3115, 3397, 4066], '4).': [3117, 4071, 4307, 4525], 'Interestingly,': [3118, 6190], 'removal': [3125, 6251], 'level': [3136, 4549, 5509], 'even': [3141, 4540], 'though': [3142], 'shift': [3146], 'visible': [3151, 4554], '(lane': [3152, 4306, 4355, 4537, 4586, 4601], '5).': [3153, 3404], 'Thus': [3154, 5108], 'correlate': [3162, 4639], 'these': [3164, 3519, 3690, 3847, 4384, 4591, 5464, 6094, 6210], 'conditions.': [3165], 'Similar': [3166, 4559, 5141], 'inducibly': [3180, 5151], 'vitro,': [3206], 'coupled': [3207], '(37Alessi': [3212], 'Ashworth': [3216], 'Cowley': [3218], 'Methods': [3224], 'Enzymol.': [3225], '255:': [3227], '279-290Crossref': [3228], '(155)': [3231], '38Fantl': [3234], 'W.J.': [3235], 'Muslin': [3236], 'Kikuchi': [3238], 'Martin': [3240], 'MacNicol': [3242], 'A.M.': [3243], 'Gross': [3244], 'R.W.': [3245], '371:': [3250], '612-614Crossref': [3251], '(309)': [3254], 'Immunecomplexed': [3257], 'His-tagged': [3266], 'ERK2': [3267, 4506, 4574], 'specific': [3271, 5713], 'MEK.': [3273], 'Also': [3274], '6–8-fold': [3286], 'interphase': [3295], 'best': [3301], 'characterized': [3302], 'upstream': [3303, 4777], 'activator': [3304, 6340], 'protein,': [3318], 'translocated': [3322], 'place.': [3332], 'Fold': [3359], 'correction': [3364], 'immune': [3375], 'complexes.': [3376], 'blocked': [3388], 'EGF-induced': [3389], '3,': [3394, 3466, 3468, 3497, 3514], 'lanes': [3396, 3401, 3467, 3728, 4064, 4068, 4116, 4121, 4161, 4166, 4290], '6': [3399, 3769], 'evidence': [3407, 4309], 'Raf/Ras': [3409], 'physically': [3431], 'RafR89L': [3443, 4369], 'elevated': [3445], 'similar': [3450, 4056, 4424, 4484, 5516], 'levels': [3451], 'like': [3452], 'inhibited': [3461, 5633], 'coexpressed': [3463], '8,': [3469], '10).': [3471], 'coexpression': [3473, 3734, 4172], '(RafNT),': [3480], 'blocks': [3482], 'Ras-dependent': [3484, 3532, 4250, 4272, 5066], 'activation,': [3486, 4874], 'lane': [3498, 3515, 3763, 3768, 4524], '13).': [3499], 'contrast,': [3501, 4527], 'EGF-dependent': [3503, 5187], 'RafNT': [3512, 5177], '12).': [3516], 'Taken': [3517, 4382], 'together': [3518], 'neither': [3523], 'direct': [3524], 'nor': [3530], 'other': [3531, 4652, 6378], 'mechanisms': [3533, 3869, 4394, 5217, 5597, 5704, 5779], 'synergizes': [3547], 'Raf.': [3556], 'Recently': [3557, 5345], 'published': [3561], 'activate': [3573, 5737], 'Therefore': [3599], 'tested': [3601], 'plays': [3606], 'fibroblast-like': [3616], 'study.': [3622], 'RafYY340/341FF': [3626, 3671, 3711, 5444, 5486], 'phenylalanines': [3637], '4,': [3666, 3727, 3761], 'comparelanes': [3667], '7).': [3670], '4,lanes': [3685], '6).': [3688, 3731, 4209, 5594], 'may': [3694, 4649, 5472, 5657, 5835, 6423], 'some': [3696, 5288], 'However,': [3703, 3783, 4125, 5481], 'weak': [3705, 4824], 'suggests': [3712, 3802, 6207], 'led': [3738], 'RafYY340/341YY,': [3748], 'because': [3749], 'Src-dependent': [3750, 4692], '340/341': [3759], 'with8).': [3770], 'phosphoamino': [3778], 'acid': [3779], 'analyses': [3780], 'performed.': [3782, 3974], 'serine': [3785], 'detected': [3793, 4038, 4610, 5403], 'This': [3801, 4333, 5246, 6033, 6071], '340': [3809], '341': [3811], 'seem': [3812], 'very': [3823], 'subpopulation': [3825], 'residues,': [3832], 'lower': [3835, 4114], 'than': [3836, 4653], 'limit.': [3839], 'Another': [3840, 6354], 'explanation': [3841], 'initial': [3853, 5274, 6472], 'maintenance': [3861], 'Most': [3868], 'known': [3870, 5215], 'responsible': [3873], 'involve': [3878, 5599], 'membrane-bound': [3893, 4220, 5231, 6224], 'Deactivation': [3907], 'return': [3913], '(39Wartmann': [3922], 'Hofer': [3924], 'Turowski': [3926], 'Saltiel': [3928], 'A.R.': [3929], 'Hynes': [3930], 'N.E.': [3931], '272:': [3936], '3915-3923Abstract': [3937], '(64)': [3945], 'Since': [3948], 'localization': [3959, 4244, 5248], 'investigated.': [3967], 'this,': [3969, 4260], 'obtain': [3990], '(P100)': [3994], '(S100).': [3999], 'matched': [4013], 'before': [4014], 'centrifugation.': [4017], '5,lower': [4042], 'contain': [4055], '(e.g.': [4061], 'Fig.': [4062, 4415], '5,': [4063, 4087, 4113, 4157], '1and': [4065], 'overexpressing': [4092, 4513], 'about': [4101], 'higher': [4104], 'versus': [4108, 4120], 'panel,': [4115, 4159], '3).': [4124, 4169, 4558], '11-fold': [4132], 'increased': [4133, 4140, 4619], 'correlating': [4188], 'strong': [4191], 'Overexpression': [4210], '7': [4224], '8),': [4226], 'implying': [4227], 'overriding': [4233], 'otherwise': [4235], 'Next,': [4241], 'EGF,': [4266, 4532], 'manner.': [4273], 'EGF-mediated': [4274], '(compare': [4289], '9': [4291], '10),': [4293], 'clearly': [4295], 'differed': [4296], 'location': [4301], 'Further': [4308], 'RafR89L.': [4332], 'mutant,': [4335], 'behaved': [4342], 'similarly': [4343], '14).': [4356], 'Coexpression': [4357], 'well': [4374, 4498, 4706], '15–18).': [4381], 'together,': [4383], 'EGF.': [4432], 'Raf/MEK/ERK': [4447], 'detects': [4469], 'ERK2.': [4477], 'samples': [4488], 'recognizing': [4494], 'Rafwt': [4514], 'form': [4517, 6044], 'detectable': [4521, 4597], '6,': [4523], 'strongly': [4535, 4618, 6206], '2),': [4538], 'starved': [4542], 'untransfected': [4564], 'Ectopic': [4569], 'epitope-tagged': [4573], 'EGF-stimulated': [4584], '6),': [4587], '8).': [4602], 'pathway,': [4645], 'suggesting': [4646], 'use': [4650, 5169], 'substrates': [4651, 6220], 'there': [4664, 4985, 5695], 'general': [4667], 'block': [4668, 6255], 'Raf-1-dependent': [4670], 'constitutively': [4679, 4697, 5675], 'mutants,': [4682], 'RafCT': [4683], 'v-Raf,': [4688], 'RafY340D': [4690], 'mimicking': [4691], 'activation.': [4693, 5522], 'Expression': [4694], 'down-regulation': [4719, 5685, 6384], 'overcome': [4723, 5681], 'originally': [4730], 'discovered': [4731], 'retroviruses': [4739], 'Scholar),': [4758, 4983, 5060], 'mitogens': [4762], 'transduction': [4768, 6359], 'many': [4770, 4971], 'systems.': [4772], 'regulators': [4778, 4878], 'Upon': [4786, 4989], 'translocates': [4796], 'factors': [4804, 5735, 6127], 'full': [4807], 'factor-activated': [4812], 'phosphoryation': [4825], 'Tyr': [4827, 5400], '23Morrison': [4848], 'cytokine-dependent': [4873], 'Jak': [4891], 'family,': [4892], '40Xia': [4924], 'Mukhopadhyay': [4926], 'Inhorn': [4928], 'R.C.': [4929], 'Barber': [4930], 'D.L.': [4931], 'Rose': [4932], 'P.E.': [4933], 'Lee': [4934], 'Narsimhan': [4936], 'R.P.': [4937], "D'Andrea": [4938], 'Griffin': [4940], 'J.D.': [4941], '93:': [4952], '11681-11686Crossref': [4953], '(74)': [4956], 'synergism': [4960], 'systems': [4972], 'exceptions.': [4988], 'stimualtion': [4990], 'CD4': [4993], 'lymphocytes': [4996], '(41Popik': [5008], 'Pitha': [5010], '6532-6541Crossref': [5017], 'We': [5021, 6427, 6451, 6466, 6488], 'fine-tuned': [5113, 5698], 'interplay': [5116], 'number': [5119], 'various': [5121], 'signals.': [5122], 'describe': [5128], 'several': [5164], 'lines': [5165, 6096], 'evidence.': [5167], 'deficient': [5197], 'ability': [5201], 'most': [5214], 'cytoplasm.': [5245], 'consistent': [5253], 'Although': [5261], 'answer': [5268], 'question': [5270], 'takes': [5278], 'place,': [5279], 'observation': [5281], 'implies': [5287, 5487], 'so': [5289], 'far': [5290], 'unknown': [5291, 6380], 'biological': [5292], 'relevance': [5293], 'Kinases': [5313], '(42Laird': [5331, 5543, 5640, 6138, 6256], 'Signalling.': [5336, 5548, 5645, 6143, 6261], '249-255Crossref': [5339, 5551, 5648, 6146, 6264], '(46)': [5342, 5554, 5651, 6149, 6267], 'Lck-dependent': [5347], 'our': [5387], 'study,': [5388], 'finding': [5439], 'indicates': [5462], 'therefore': [5469], 'modest': [5483], 'step': [5492], 'must': [5495, 6297], 'exist': [5496], '340/341.': [5507], 'usual': [5525], 'MEK,': [5529], 'mitogen-stimulated': [5541], 'down-regulated': [5565, 6244], '(43Edelmann': [5569], 'H.M.L.': [5570, 6271], 'Kuhne': [5571, 6272], 'Petritsch': [5573, 6274], 'Ballou': [5575, 6276], 'L.M.': [5576, 6277], '963-971Abstract': [5582, 6283], '(91)': [5590, 6291], 'how': [5612], 'uncoupled': [5616], 'unknown.': [5621, 5791], 'MEK2': [5628], 'mitosis-specific': [5636], 'Cdc2/cyclin': [5637, 6333], 'B': [5638, 6334], 'complex': [5639, 5899], 'phosphatases': [5656, 5712], 'induced': [5659], 'specifically': [5663, 6167], 'inactivate': [5664, 6101], 'MEK1/2': [5665, 6240], 'ERK1/2.': [5667], 'It': [5668, 6118, 6170, 6231, 6304], 'interest': [5671, 6174, 6308], 'mutants': [5677, 6444], 'exists': [5696], 'balance': [5699], 'inactivation': [5703], 'MEK/ERK.': [5706], 'Nocodazole': [5707], 'mediate': [5709], 'if': [5719], 'activated.': [5724], 'detached': [5732], '(44Renshaw': [5746], 'M.W.': [5747], 'Ren': [5748], 'X.D.': [5749], 'Schwartz': [5750], '5592-5599Crossref': [5756], '(270)': [5759], 'additionally': [5769], 'requires': [5770], 'adhesion.': [5772], 'But': [5773], 'uncoupling': [5784], 'Ras/Raf-1': [5786], 'influence': [5794], 'machinery': [5798], 'points.': [5801], 'G0': [5803], 'expression.': [5825], 'During': [5826], 'G1/S': [5828, 6328], 'transition': [5829, 6110], 'dual': [5847], 'specificity': [5848], 'Cdc25A': [5850, 5893, 6325], '(45Conklin': [5856], 'D.S.': [5857], 'Galaktionov': [5858], 'Beach': [5860, 5881], '7892-7896Crossref': [5871], '(246)': [5874], '46Galaktionov': [5877], 'Jessus': [5879], 'Genes': [5883, 5945], '1046-1058Crossref': [5887], '(230)': [5890], 'Cdk2/cyclin': [5897], 'E': [5898], 'progression': [5903], 'cycle.': [5907], 'strength': [5917], 'induce': [5924], 'proliferation': [5926], 'arrest': [5930, 6030, 6035, 6064], 'G1': [5932, 6034], '(47Lloyd': [5933], 'A.C.': [5934, 5983], 'Obermuller': [5935], 'F.': [5936], 'Staddon': [5937], 'Barth': [5939], 'C.F.': [5940], 'McMahon': [5941, 5965], 'Land': [5943, 5984], '11:': [5948], '663-677Crossref': [5949], '(206)': [5952], '48Woods': [5955], 'Parry': [5957], 'Cherwinski': [5959], 'Bosch': [5961], 'Lees': [5963], '17:': [5971, 5990, 6410], '5598-5611Crossref': [5972], '(577)': [5975], '49Sewing': [5978], 'Wiseman': [5980], 'Lloyd': [5982], '5588-5597Crossref': [5991], '(419)': [5994], 'While': [5997], 'induces': [6002], 'G1-specific': [6006], 'cyclin': [6007], 'D': [6008], 'p21CIP': [6025], 'G1.': [6032], 'tumor': [6047], 'suppressor': [6048], 'p53.': [6049, 6102], 'show': [6062], 'RasG12V.': [6070], 'explained': [6074], 'presence': [6077, 6192], 'SV40': [6080], 'large': [6081], 'antigen': [6083], 'polyoma': [6085], 'antigen,': [6087], 'immortalization': [6092], 'function': [6104], 'known.': [6117], 'discussed': [6121], 'transcription': [6126, 6133, 6188], 'repression': [6131], 'observed': [6134], 'c-Myc': [6152], 'Ets-1,': [6154], 'downstream': [6157], 'targets': [6158], 'signaling,': [6164], 'hyperphosphorylated': [6166], 'determine': [6176], 'factors.': [6189], 'subset': [6218], 'stimulation.': [6230], 'ERK1/2': [6242], '43Edelmann': [6270], 'know': [6310], 'Cdc25C,': [6317], 'transition.': [6329], 'Cdc25C': [6330], 'complex,': [6335], 'Src.': [6342, 6353], 'Thereby': [6343], 'indirectly': [6347], 'aspect': [6355], 'microtubule': [6367], 'dynamics.': [6368], 'oncoprotein': [6373], '18': [6374], 'Cdc2': [6376], 'activity,': [6387], 'passage': [6393], '(50Larsson': [6396], 'Marklund': [6398], 'Gradin': [6400], 'H.M.': [6401], 'Brattsand': [6402], 'Gullberg': [6404], '5530-5539Crossref': [6411], '(169)': [6414], 'process': [6419], 'role.': [6426], 'grateful': [6429], 'Alfred': [6431], 'Wittinghofer,': [6432], 'Raymond': [6433], 'Erikson,': [6435], 'Tony': [6437], 'providing': [6440], 'encoding': [6443], 'MEK1,': [6447], 'respectively.': [6450], 'thank': [6452, 6468, 6490], 'Jochen': [6453], 'Heinrich': [6454], 'inducible': [6464], 'promoter.': [6465], 'Josip': [6469], 'Lovrić': [6470], 'help,': [6473], 'Michael': [6474], 'Nawrath': [6475], 'help': [6477], 'analysis,': [6481], 'Yvonne': [6483], 'Schäefli': [6484], 'technical': [6486], 'assistance.': [6487], 'Sven': [6491], 'Zimmermann': [6492], 'Chris': [6494], 'Hovens': [6495], 'helpful': [6497], 'discussions': [6498], 'critical': [6500], 'reading': [6501], 'manuscript.': [6504]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2127322842', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-14T06:07:50.260277', 'created_date': '2016-06-24'}
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