Hypoxia-inducible Factor-1-mediated Expression of the 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) Gene

Name: Work Video:
Duration: 3 min 30 s
О. H. Minchenko; Irene Leshchinsky; Irina Opentanova; Nianli Sang; Vickram Srinivas; Valerie E. Armstead; J. Jaime
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218, 222, 283, 293, 308, 320, 333, 339, 382, 385, 400, 405, 423, 436, 454, 463, 518, 532, 588, 954, 960, 1078, 1087, 1178, 1182, 1255, 1265, 1408, 1411, 1416, 1552, 1570, 1650, 1677, 1694, 1703, 1711, 1728, 1809, 1855, 1866, 2067, 2094, 2103, 2109, 2126, 2136, 2154, 2168, 2203, 2269, 2331, 2357, 2398, 2433, 2468, 2480, 2515, 2527, 2582, 2591, 2605, 2622, 2685, 2710, 2722, 2808, 2821, 2964, 3026, 3035, 3203, 3216, 3229, 3235, 3250, 3310, 3358, 3379, 3403, 3411, 3497, 3549, 3555, 3576, 3712, 3758, 3769, 3776, 3785, 3796, 3801, 3833, 3841, 3927, 3939, 4043, 4046, 4056, 4095, 4124, 4133, 4255, 4258, 4266, 4346, 4363, 4458, 4463, 4561, 4569, 4577, 4586, 4593, 4637, 4653, 4663, 4749, 4751, 4753, 4811, 4832, 4850, 4856, 4909, 4931, 4935, 4969, 5035, 5039, 5059, 5085, 5099, 5104, 5144, 5150, 5157, 5163, 5198, 5213, 5248, 5265, 5268, 5315, 5427, 5564, 5574, 5596], 'the': [2, 6, 13, 21, 63, 88, 107, 127, 151, 163, 169, 175, 189, 204, 219, 223, 230, 238, 280, 305, 324, 344, 368, 380, 386, 392, 406, 421, 440, 449, 455, 470, 475, 505, 521, 657, 855, 951, 955, 958, 1057, 1171, 1176, 1183, 1246, 1253, 1324, 1414, 1417, 1425, 1542, 1571, 1648, 1654, 1695, 1700, 1709, 1864, 1960, 2037, 2089, 2124, 2204, 2270, 2317, 2329, 2358, 2385, 2434, 2451, 2516, 2553, 2606, 2672, 2681, 2883, 2888, 2893, 2962, 3204, 3227, 3232, 3236, 3251, 3293, 3320, 3329, 3336, 3355, 3359, 3363, 3374, 3382, 3406, 3553, 3574, 3656, 3710, 3720, 3773, 3782, 3788, 3794, 3808, 3812, 3829, 3839, 3919, 3925, 3936, 3944, 3951, 3965, 4038, 4044, 4047, 4054, 4057, 4067, 4112, 4117, 4122, 4131, 4139, 4256, 4274, 4282, 4347, 4350, 4378, 4456, 4461, 4559, 4567, 4578, 4587, 4651, 4758, 4808, 4812, 4844, 4848, 4851, 4899, 4932, 4936, 4958, 4967, 5031, 5036, 5047, 5053, 5060, 5075, 5082, 5086, 5102, 5113, 5140, 5145, 5148, 5158, 5196, 5199, 5238, 5249, 5262, 5316, 5327, 5418, 5524, 5548, 5552, 5568, 5579, 5588, 5594], 'key': [3, 101, 220, 318, 522, 5114], 'mediators': [4, 221], 'hypoxic': [7, 30, 207, 224, 247, 424, 1151, 1331, 1655, 1958, 2003, 2875, 3233, 3356, 3383, 3589, 3799, 4291, 5083, 5239], 'response': [8, 31, 225, 248, 1173, 1656, 3102, 3208, 3234, 3337, 3800, 4055, 4104, 4141, 4250, 4298, 4343, 5207, 5255], 'in': [9, 19, 34, 62, 199, 209, 226, 236, 251, 279, 416, 426, 525, 655, 839, 845, 867, 939, 1062, 1287, 1643, 1653, 1658, 1680, 1780, 1839, 1968, 2088, 2147, 2315, 2719, 2779, 2983, 2997, 3003, 3042, 3187, 3207, 3220, 3231, 3299, 3313, 3319, 3350, 3362, 3373, 3381, 3405, 3564, 3573, 3591, 3608, 3661, 3744, 3763, 3787, 3956, 3970, 4079, 4082, 4142, 4249, 4273, 4356, 4566, 4671, 4828, 4957, 5030, 5057, 5081, 5119, 5167, 5256, 5261, 5420, 5512, 5532], 'animal': [10, 227], 'cells': [11, 46, 72, 201, 228, 263, 289, 418, 1064, 1158, 1770, 1777, 1896, 1940, 2176, 2406, 3044, 3085, 3222, 3276, 3280, 3305, 3386, 3728, 3749, 3765, 3791, 3819, 4271, 4285, 4573, 4583, 4632, 5534, 5553], 'is': [12, 23, 32, 59, 106, 145, 229, 240, 249, 276, 323, 362, 443, 458, 501, 514, 607, 936, 1074, 1082, 1156, 1189, 1259, 1320, 1706, 3008, 3018, 3028, 3340, 3371, 3397, 3416, 3761, 3804, 3828, 3949, 4253, 4372, 5112, 5123, 5135, 5139, 5202, 5252, 5325, 5408, 5417, 5507, 5528], 'hypoxia-inducible': [14, 231, 704, 721, 1247], 'transcription': [15, 232, 1248, 4949, 5048, 5264], 'factor-1': [16, 233, 1249], '(HIF-1)': [17, 234, 1250], 'complex,': [18, 235], 'which': [20, 131, 237, 348, 597, 866, 1276, 3335, 3423, 3647, 4089, 4146, 4453, 4546, 4914, 5165, 5527], 'α-subunit': [22, 239, 1274], 'highly': [24, 146, 241, 363, 444, 3954], 'susceptible': [25, 242], 'to': [26, 48, 243, 265, 503, 744, 1160, 1162, 1174, 1330, 1999, 2117, 2197, 2265, 2297, 2351, 2427, 2457, 2509, 2542, 2616, 2649, 2659, 2676, 2680, 2796, 3103, 3209, 3283, 3338, 3342, 3551, 3581, 3585, 3666, 3736, 3793, 3824, 3964, 4073, 4101, 4105, 4111, 4161, 4164, 4251, 4299, 4344, 4596, 5044, 5052, 5224, 5233, 5237, 5310, 5360, 5509], 'oxygen-dependent': [27, 244, 3401], 'degradation.': [28, 245, 1549, 3934, 4556], 'The': [29, 185, 246, 402, 434, 584, 851, 1405, 1520, 1550, 1935, 2150, 2242, 2342, 2367, 2390, 2464, 2549, 2578, 2612, 2766, 2789, 2877, 3033, 3347, 3377, 3756, 3798, 4103, 4241, 4264, 4342, 4450, 4629, 4743, 4821, 4838, 4854, 4863, 5246], 'manifested': [33, 61, 250, 278, 3805, 4303], 'many': [35, 67, 252, 284, 1088], 'pathophysiological': [36, 253, 1089], 'processes': [37, 254, 1090], 'such': [38, 255, 3369, 3674, 5350], 'as': [39, 256, 527, 529, 1053, 1153, 1541, 2005, 2340, 2609, 2748, 2838, 2902, 3001, 3105, 3192, 3194, 3426, 3602, 3675, 4136, 4293, 4295, 4548, 4590, 5305, 5351, 5416, 5424], 'tumor': [40, 71, 257, 288, 1092, 5257, 5354, 5533], 'growth': [41, 258, 488, 498, 647, 713, 730, 1093, 4288, 5217, 5338, 5346], 'and': [42, 94, 135, 150, 155, 181, 202, 259, 311, 352, 367, 372, 398, 419, 446, 451, 466, 474, 586, 601, 611, 649, 663, 848, 860, 966, 1094, 1186, 1272, 1278, 1297, 1307, 1534, 1537, 1539, 1567, 1646, 1670, 1683, 1718, 1751, 1757, 1771, 1792, 1798, 1837, 1869, 1897, 1941, 1978, 1990, 2045, 2083, 2106, 2145, 2177, 2190, 2201, 2286, 2319, 2346, 2355, 2377, 2407, 2420, 2431, 2445, 2489, 2502, 2513, 2599, 2620, 2640, 2662, 2674, 2702, 2717, 2739, 2794, 2874, 2940, 2967, 2988, 2993, 3017, 3037, 3049, 3094, 3108, 3211, 3277, 3288, 3331, 3578, 3616, 3653, 3670, 3677, 3734, 3753, 3810, 3835, 3917, 3933, 4116, 4150, 4312, 4349, 4374, 4563, 4574, 4640, 4746, 4762, 4768, 4834, 4902, 4943, 4971, 5063, 5128, 5130, 5160, 5171, 5218, 5230, 5273, 5284, 5332, 5337, 5344, 5348, 5353, 5554, 5601], 'metastasis.': [43, 260], 'During': [44, 261, 1170, 1317], 'hypoxia,': [45, 262, 1175, 1668, 2965, 2986, 3314, 4053], 'shift': [47, 264, 2834, 2885, 3349], 'a': [49, 266, 592, 962, 1075, 1260, 1268, 1524, 1530, 1674, 1726, 1942, 1969, 1981, 2110, 2169, 2299, 2311, 2332, 2399, 2459, 2481, 2544, 2592, 2651, 2774, 3200, 3241, 3247, 3307, 3427, 3545, 3582, 3730, 3738, 3770, 4076, 4091, 4364, 4549, 4591, 4654, 4661, 4829, 4940, 5096, 5155, 5253, 5266, 5425], 'primarily': [50, 267], 'glycolytic': [51, 68, 83, 92, 104, 268, 285, 300, 309, 321, 441, 658, 871, 1059, 1184, 3967, 4048, 4297, 5061, 5317], 'metabolic': [52, 269, 452, 5176], 'mode': [53, 270], 'for': [54, 174, 215, 271, 391, 432, 957, 964, 1056, 1275, 1422, 1548, 1860, 1965, 2152, 2160, 2304, 2328, 2384, 2466, 2472, 2552, 2580, 2733, 2742, 2783, 2827, 2882, 3030, 3090, 3285, 3328, 3334, 3569, 3651, 4041, 4555, 4760, 4764, 4898, 4947, 4966, 5523, 5557, 5567, 5578, 5587], 'their': [55, 272, 840, 846, 1164, 1898, 3091, 3101, 3195, 4162, 4594, 4765, 5222, 5231, 5235, 5243], 'energetic': [56, 273, 450, 1165, 3092], 'needs.': [57, 274], 'This': [58, 157, 275, 374, 604, 1993, 2308, 2536, 3414, 4896], 'also': [60, 80, 277, 297, 844, 1083, 3040, 3950, 5358, 5592], 'HIF-1-dependent': [64, 281, 3672, 4588], 'up-regulation': [65, 282, 4568, 4831], 'genes.': [69, 286, 1257], 'Paradoxically,': [70, 287], 'growing': [73, 290], 'under': [74, 291, 660, 1066, 2715, 3503, 4290, 5174, 5413], 'conditions': [75, 292, 665, 1332, 3505, 4292, 5177, 5240, 5415], 'normal': [77, 294, 1067, 3107, 3201, 4140], 'oxygen': [78, 295, 1068, 1284, 1995, 3816, 4454, 4673, 5214, 5272], 'tension': [79, 296, 1069], 'show': [81, 140, 298, 357, 4099, 4633], 'elevated': [82, 299, 863, 952, 4634], 'rates': [84, 301, 872, 948, 1060], 'that': [85, 141, 302, 358, 613, 949, 1527, 1545, 1667, 1699, 2656, 3045, 3586, 3960, 4037, 4071, 4246, 4281, 4643, 4667, 4807, 4825, 4843, 5116, 5137, 5193, 5208, 5270, 5323, 5330, 5511], 'correlate': [86, 303], 'with': [87, 304, 460, 1424, 1785, 1847, 1980, 2064, 2120, 2132, 2142, 2291, 2380, 2455, 2540, 2643, 3015, 3246, 3645, 3766, 4066, 4159, 4544, 4963, 5204, 5313, 5599, 5604], 'increased': [89, 306, 1190, 3783], 'expression': [90, 307, 1177, 1277, 2996, 3601, 3757, 4652, 5197], 'enzymes': [93, 172, 310, 389, 1185, 1574, 3499, 4045, 4473, 4666, 5062], 'glucose': [95, 312, 437, 709, 726, 1187, 1841, 3842], 'transporters': [96, 313, 1188], '(the': [97, 314, 1070, 1167], 'Warburg': [98, 315, 1071, 5525], 'effect).': [99, 316, 1072, 1169], 'A': [100, 317, 2323, 2631, 3023], 'regulator': [102, 319, 507], 'flux': [105, 322, 510], 'relatively': [108, 325], 'recently': [109, 326, 4664], 'discovered': [110, 327], 'fructose-2,6-bisphosphate': [111, 328, 701, 718], '(F-2,6-P2),': [112, 329], 'an': [113, 166, 330, 383, 515, 530, 1054, 1084, 1273, 1712, 2133, 3400, 3802, 4259, 4360, 4672, 5205, 5521], 'allosteric': [114, 331, 516], 'activator': [115, 332, 517, 3832, 5143], '6-phosphofructo-1-kinase': [117, 334, 519, 702, 719], '(PFK-1).': [118, 335], 'Steady': [119, 336], 'state': [120, 337], 'levels': [121, 338, 619, 2974, 3784, 3926, 4636, 5149], 'F-2,6-P2': [123, 340, 513, 589, 864], 'are': [124, 341, 614, 1280, 4050, 4660, 4961, 5025, 5152, 5172, 5308], 'maintained': [125, 342], 'by': [126, 148, 162, 196, 203, 343, 365, 379, 413, 420, 609, 645, 1282, 1323, 1419, 1560, 1568, 1688, 1952, 2007, 2043, 2166, 2180, 2396, 2410, 2478, 2492, 2589, 2603, 2670, 2977, 3010, 3389, 3399, 3418, 3588, 3604, 3655, 3929, 4109, 4130, 4138, 4304, 4377, 4452, 4469, 4650, 4818, 4906, 5126, 5132, 5154, 5242], 'bifunctional': [128, 345, 605], 'enzyme': [129, 346, 524, 606, 956, 1652, 3556, 3921, 5115], 'PFK-2/F2,6-Bpase,': [130, 347], 'has': [132, 349, 598, 854, 1660, 1862, 2559, 3943, 4060, 4278, 4859, 5089, 5107], 'both': [133, 350, 599, 2316, 3106, 3806], 'kinase': [134, 351, 600, 5159], 'phosphatase': [136, 353, 602, 5161], 'activities.': [137, 354, 603], 'Herein,': [138, 355], 'we': [139, 356, 1697, 3239, 3718], 'one': [142, 359], 'isozyme,': [143, 360], 'PFKFB3,': [144, 361, 3751, 4638, 5312], 'induced': [147, 364, 644], 'hypoxia': [149, 152, 366, 369, 1553, 1701, 3036, 3104, 3210, 3284, 3339, 4074, 4106, 4165, 4252, 4300, 4345, 5100, 5194, 5324], 'mimics': [153, 370], 'cobalt': [154, 371, 2966], 'desferrioxamine.': [156, 373, 3212], 'induction': [158, 208, 375, 425, 1676, 3027, 3202, 3215, 3309, 3357, 4123], 'could': [159, 376, 1051, 4644, 4815, 4920], 'be': [160, 377, 504, 643, 1558, 2677, 3343, 4645, 4816, 5321, 5517], 'replicated': [161, 378], 'use': [164, 381], 'inhibitor': [167, 384, 531, 3548], 'prolyl': [170, 387, 1572, 3421, 4471, 4564, 4579], 'hydroxylase': [171, 388, 1573, 4472, 4580], 'responsible': [173, 390], 'von': [176, 393, 706, 723, 1426], 'Hippel': [177, 394, 484, 494, 707, 724, 1427], 'Lindau': [178, 395, 708, 725, 1428], '(VHL)-dependent': [179, 396], 'destabilization': [180, 397], 'tagging': [182, 399, 1420], 'HIF-1α.': [184, 216, 401, 433, 5334], 'absolute': [186, 403, 4361], 'dependence': [187, 404], 'PFKFB3': [190, 407, 852, 1678, 2182, 2206, 2272, 2321, 2360, 2387, 2970, 2992, 3205, 3217, 3237, 3289, 3311, 3577, 3715, 3942, 4068, 4348, 4570, 4833, 4852, 4937, 5087, 5105, 5200, 5515], 'gene': [191, 408, 1079, 1705, 2971, 3206, 3253, 4059, 4126, 4247, 4858, 4864, 4938, 5088], 'on': [192, 409, 1554, 1708, 2773, 2969, 3088, 3100, 3345, 3558, 3714, 4153, 5101, 5221], 'HIF-1': [193, 410, 1258, 1714, 3230, 3360, 4267, 4366, 5077, 5250], 'was': [194, 411, 1725, 1736, 1745, 1997, 2030, 2130, 2164, 2184, 2245, 2274, 2295, 2326, 2371, 2382, 2394, 2414, 2453, 2476, 2496, 2530, 2538, 2587, 2634, 2647, 2657, 2688, 2791, 2810, 2825, 2934, 2943, 2958, 3039, 3218, 3290, 3387, 4107, 4127, 4268, 4353], 'confirmed': [195, 412, 3388], 'its': [197, 414, 653, 1334, 1641, 3643, 3931, 4080], 'overexpression': [198, 415], 'VHL-deficient': [200, 417, 3747, 4582, 4630], 'lack': [205, 422, 3046, 4147], 'mouse': [210, 427, 1684, 2333, 2336, 2359, 2386, 2469, 2487, 2517, 2583, 2595, 2623, 2661, 3242, 5580], 'embryonic': [211, 428, 1795, 5581], 'fibroblasts': [212, 429, 1796, 1859], 'conditionally': [213, 430, 1857], 'nullizygous': [214, 431, 1858], 'rate': [435, 659, 3840, 3968, 4289], 'utilization': [438, 3843], 'via': [439], 'pathway': [442, 1657, 4049], 'regulated': [445, 608], 'depends': [447, 590, 5220], 'upon': [448, 591, 616], 'needs': [453], 'cell.': [456], 'It': [457, 1081, 3913, 3948, 4277, 5122, 5134, 5259, 5319, 5506], 'coordinated': [459], 'other': [461, 4467, 5428], 'pathways': [462], 'energy': [464], 'generation': [465], 'utilization,': [467], 'notably': [468], 'gluconeogenesis,': [469, 1647], 'pentose': [471], 'phosphate': [472], 'pathway,': [473], 'citric': [476], 'acid': [477, 2038, 4310], 'cycle.': [478], 'Fructose-2,6-bisphosphate': [479], '(F-2,6-P2)': [480], '1F-26-P2,': [481, 491], 'fructose-2,6-bisphosphatePFK-16-phosphofructo-1-kinasePFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase-3HIF-1αhypoxia-inducible': [482, 492], 'factor-1αVHLvon': [483, 493], 'LindauGlut-1glucose': [485, 495], 'transporter-1VEGFvascular': [486, 496], 'endothelial': [487, 497, 712, 729], 'factorHREhypoxia-responsive': [489, 499], 'element': [490, 500, 716, 733], 'considered': [502], 'major': [506], 'controlling': [508], 'carbon': [509, 1988], 'through': [511], 'glycolysis.': [512, 3826], '(PFK-1),': [520], 'regulatory': [523, 849], 'glycolysis': [526, 1161, 1645, 3089, 3834, 5118, 5210], 'well': [528, 3193, 4294, 4861], 'frucrose-1,6-bisphosphatase': [533], '(1Kawaguchi': [534, 3844], 'T.': [535, 914, 1005, 1027, 2566, 2754, 3845, 4013], 'Veech': [536, 3846], 'R.L.': [537, 3847], 'Uyeda': [538, 748, 3848], 'K.': [539, 749, 1033, 1434, 1578, 3849, 4328, 4477], 'J.': [540, 667, 747, 773, 795, 820, 874, 923, 969, 1003, 1015, 1228, 1339, 1362, 1363, 1389, 1440, 1470, 1584, 1613, 1918, 1919, 2020, 2228, 2570, 2758, 2852, 2853, 2915, 2916, 3067, 3068, 3121, 3122, 3152, 3438, 3460, 3515, 3633, 3850, 3973, 4022, 4177, 4178, 4208, 4384, 4407, 4408, 4434, 4483, 4513, 4685, 4707, 4779, 5368, 5369, 5392, 5396, 5446], 'Biol.': [541, 1229, 1364, 1390, 1920, 2854, 2917, 3069, 3123, 3153, 3851, 4179, 4209, 4333, 4409, 4435, 5370], 'Chem.': [542, 1230, 1365, 1391, 1921, 2855, 2918, 3070, 3124, 3154, 3852, 4180, 4210, 4410, 4436, 5371], '2001;': [543, 1453, 1489, 1512, 1597, 1632, 1922, 2856, 2919, 3071, 3125, 3177, 3470, 3488, 3534, 3634, 3853, 4181, 4233, 4334, 4496, 4532, 4717, 4735, 4798, 4888, 5013, 5498], '276:': [544, 1923, 2857, 2920, 3072, 3126, 3854, 4182], '28554-28561Abstract': [545, 3855], 'Full': [546, 548, 1234, 1236, 1369, 1371, 1395, 1397, 1925, 1927, 2859, 2861, 2922, 2924, 3074, 3076, 3128, 3130, 3158, 3160, 3473, 3475, 3856, 3858, 4184, 4186, 4214, 4216, 4414, 4416, 4440, 4442, 4720, 4722, 5375, 5377, 5451, 5453], 'Text': [547, 549, 1235, 1237, 1370, 1372, 1396, 1398, 1926, 1928, 2860, 2862, 2923, 2925, 3075, 3077, 3129, 3131, 3159, 3161, 3474, 3476, 3857, 3859, 4185, 4187, 4215, 4217, 4415, 4417, 4441, 4443, 4721, 4723, 5376, 5378, 5452, 5454], 'PDF': [550, 1238, 1373, 1399, 1929, 2863, 2926, 3078, 3132, 3162, 3477, 3860, 4188, 4218, 4418, 4444, 4724, 5379, 5455], 'PubMed': [551, 566, 579, 634, 695, 757, 778, 800, 829, 902, 928, 997, 1021, 1044, 1124, 1209, 1239, 1354, 1374, 1400, 1456, 1492, 1515, 1600, 1635, 1930, 2025, 2056, 2237, 2864, 2927, 3079, 3133, 3163, 3180, 3478, 3491, 3537, 3637, 3703, 3861, 3876, 3889, 3908, 4001, 4027, 4189, 4219, 4236, 4337, 4399, 4419, 4445, 4499, 4535, 4624, 4725, 4738, 4801, 4891, 4995, 5016, 5186, 5380, 5400, 5456, 5477, 5501, 5541], 'Scopus': [552, 567, 580, 635, 696, 758, 779, 801, 830, 903, 929, 998, 1022, 1045, 1125, 1210, 1240, 1355, 1375, 1401, 1457, 1493, 1516, 1601, 1636, 1931, 2057, 2238, 2865, 2928, 3080, 3134, 3164, 3181, 3479, 3492, 3538, 3638, 3704, 3862, 3877, 3890, 3909, 4002, 4028, 4190, 4220, 4237, 4338, 4400, 4420, 4446, 4500, 4536, 4625, 4726, 4739, 4802, 4892, 4996, 5017, 5187, 5401, 5457, 5478, 5502, 5542], '(63)': [553, 3863], 'Google': [554, 569, 582, 637, 698, 760, 781, 803, 832, 905, 931, 1000, 1024, 1047, 1127, 1148, 1212, 1242, 1315, 1357, 1377, 1403, 1459, 1495, 1518, 1603, 1638, 1835, 1890, 1933, 2026, 2059, 2240, 2576, 2764, 2867, 2930, 3082, 3136, 3166, 3183, 3273, 3481, 3494, 3540, 3640, 3706, 3864, 3879, 3892, 3911, 4004, 4030, 4192, 4222, 4239, 4340, 4402, 4422, 4448, 4502, 4538, 4627, 4728, 4741, 4804, 4894, 4998, 5019, 5072, 5189, 5301, 5381, 5403, 5459, 5480, 5504, 5544], 'Scholar,': [555, 570, 761, 782, 804, 906, 1001, 1025, 1128, 1213, 1358, 1378, 1460, 1496, 3137, 3167, 3482, 3865, 3880, 3893, 4005, 4193, 4223, 4403, 4423, 4503, 4729, 4999, 5293, 5382, 5460, 5481], '2Hue': [556, 3866], 'L.': [557, 1388, 3867, 4433, 4880, 5005], 'Rousseau': [558, 3868], 'G.G.': [559, 3869], 'Adv.': [560, 3870], 'Enzyme': [561, 3871], 'Regul.': [562, 3872], '1993;': [563, 3873], '33:': [564, 3874], '97-110Crossref': [565, 3875], '(74)': [568, 3878], '3Okar': [571, 3881], 'D.A.': [572, 3882, 5179], 'Lange': [573, 626, 766, 3883, 3900, 5180], 'A.J.': [574, 627, 767, 3884, 3901, 5181], 'Biofactors.': [575, 3885, 5182], '1999;': [576, 692, 899, 994, 1392, 3700, 3886, 3998, 4437, 4621, 5183], '10:': [577, 3887, 5184, 5499], '1-14Crossref': [578, 3888, 5185], '(119)': [581, 3891, 5188], 'Scholar).': [583, 638, 699, 833, 932, 1048, 1149, 1243, 1316, 1404, 1519, 1639, 1891, 1934, 2027, 2060, 2241, 2577, 2765, 2931, 3083, 3184, 3274, 3495, 3541, 3707, 3912, 4031, 4240, 4341, 4449, 4539, 4628, 4742, 4895, 5020, 5073, 5190, 5302, 5404, 5505, 5545], 'synthesis': [585, 641, 959, 2153, 2167, 2330, 2397, 2467, 2479, 2581, 2590, 3932], 'degradation': [587, 1335, 3654], 'single': [593], 'enzyme,': [594], '6-phosphofructo-2-kinase/fructose-2,6-biphosphatase': [595, 2156], '(PFK-2/F-2,6-BPase),': [596], 'phosphorylation': [610, 1155, 3823], 'dephosphorylation': [612], 'dependent': [615, 1707, 3344], 'intracellular': [617, 1283], 'cAMP': [618], '(4Pilkis': [620], 'S.J.': [621, 1472, 1615, 3517, 3895, 4515, 4781], 'Claus': [622, 3896], 'T.H.': [623, 3897], 'Kurland': [624, 3898], 'I.J.': [625, 1107, 3899], 'Annu.': [628, 3902], 'Rev.': [629, 3903], 'Biochem.': [630, 750, 774, 796, 924, 1040, 2052, 3904, 4023, 4988, 5395], '1995;': [631, 3905], '64:': [632, 1042, 3906], '799-835Crossref': [633, 3907], '(226)': [636, 3910], 'Furthermore,': [639, 1687, 3000, 4121, 5147], 'PFK-2/F-2,6-BPase': [640, 1651, 3923, 3937, 4058], 'can': [642, 1557, 3500, 5357], 'mitogens,': [646], 'factors,': [648, 5339], 'inflammatory': [650], 'cytokines,': [651], 'implicating': [652], 'role': [654, 1649, 3228, 3711, 4265, 4560], 'setting': [656], 'multiple': [661], 'physiologic': [662], 'pathologic': [664], '(5Chesney': [666, 873, 968, 3972], 'Mitchell': [668, 875, 970, 3974], 'R.': [669, 684, 794, 822, 876, 891, 908, 971, 986, 1011, 1037, 1221, 1805, 2230, 3458, 3975, 3990, 4007, 4705, 4886, 4987, 5011, 5384, 5388, 5570, 5602], 'Benigni': [670, 877, 972, 3976], 'F.': [671, 810, 878, 973, 1498, 2218, 3977, 4884, 5009], 'Bacher': [672, 879, 974, 3978], 'M.': [673, 786, 788, 790, 814, 880, 910, 922, 975, 1013, 1029, 1035, 1132, 1138, 1292, 1341, 1432, 1442, 1478, 1576, 1586, 1621, 1819, 1825, 1874, 1880, 1914, 2222, 2848, 2911, 3063, 3117, 3257, 3263, 3442, 3523, 3979, 4009, 4021, 4173, 4324, 4386, 4475, 4485, 4521, 4689, 4787, 4975, 4983, 5279, 5485, 5491], 'Spiegel': [674, 881, 976, 3980], 'L.,': [675, 882, 977, 3981], 'Al-': [676, 883, 978, 3982], 'Abed': [677, 884, 979, 3983], 'Y.': [678, 885, 916, 980, 1386, 3984, 4015, 4431], 'Han': [679, 886, 981, 3985], 'J.H.': [680, 887, 982, 3986], 'Metz': [681, 888, 983, 3987], 'C.': [682, 889, 984, 2016, 3624, 3988], 'Bucala': [683, 890, 985, 3989], 'Proc.': [685, 892, 987, 1114, 1199, 1344, 1505, 3991, 4389], 'Natl.': [686, 893, 988, 1115, 1200, 1345, 1506, 3992, 4390], 'Acad.': [687, 894, 989, 1116, 1201, 1346, 1507, 3993, 4391], 'Sci.': [688, 895, 990, 1117, 1202, 1347, 1508, 3994, 4392], 'U.': [689, 896, 991, 1118, 1203, 1348, 1509, 3995, 4393], 'S.': [690, 771, 818, 897, 992, 1031, 1119, 1204, 1349, 1360, 1384, 1510, 1806, 2226, 2568, 2756, 3996, 4394, 4405, 4429, 5571], 'A.': [691, 784, 806, 898, 993, 1009, 1120, 1205, 1227, 1350, 1444, 1511, 1588, 1916, 2214, 2564, 2752, 2850, 2913, 3065, 3119, 3448, 3997, 4175, 4395, 4487, 4695, 4876, 4878, 4981, 5001, 5003], '96:': [693, 900, 995, 3999], '3047-3052Crossref': [694, 901, 996, 4000], '(244)': [697, 904, 999, 4003], '6-P2,': [700, 717], '6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-3': [703, 720], 'factor-1α': [705, 722], 'transporter-1': [710, 727], 'vascular': [711, 728], 'factor': [714, 731, 5356], 'hypoxia-responsive': [715, 732], 'Four': [734], 'different': [735, 738, 3593, 5168], 'genes': [736, 1179, 3673, 3760, 4039, 4352, 4589, 5269], 'coding': [737, 4040], 'isozymes': [739], '(PFKFB1–4)': [740], 'have': [741, 3050, 3096, 3199, 3306, 3663, 4035, 4090, 4155, 4286, 4756], 'been': [742, 1662, 2560, 3097, 3664, 4062, 4279, 4860, 5091, 5109], 'identified': [743], 'date': [745], '(6Algaier': [746], 'Biophys.': [751, 4989], 'Res.': [752, 1144, 1831, 1886, 3269, 4990], 'Commun.': [753, 4991], '1988;': [754], '153:': [755], '328-333Crossref': [756], '(38)': [759], '7Heine-Suner': [762], 'D.': [763, 1136, 1823, 1878, 3261, 5462, 5597], 'Diaz-Guillen': [764], 'M.A.': [765, 5483], 'Rodriguez': [768, 3148, 4204], 'de': [769], 'Cordoba': [770], 'Eur.': [772], '1998;': [775, 826, 1351, 2234, 4396], '254:': [776], '103-110Crossref': [777], '(31)': [780], '8Sakai': [783], 'Kato': [785, 909, 4008], 'Fukasawa': [787, 921, 1034, 4020], 'Ishiguro': [789], 'Furuya': [791], 'E.': [792, 3171, 3444, 4227, 4691, 4977, 5366, 5390, 5394, 5468], 'Sakakibara': [793, 1036, 4986], '1996;': [797, 1231, 2022], '119:': [798], '506-511Crossref': [799], '(54)': [802], '9Manzano': [805], 'Rosa': [807, 2215, 4881, 5006], 'J.L.': [808, 2216, 4882, 5007], 'Ventura': [809, 2217, 4883, 5008], 'Perez': [811, 1006, 2219], 'J.X.': [812, 2220], 'Nadal': [813, 2221], 'Estivill': [815, 2223], 'X.': [816, 1007, 2224], 'Ambrosio': [817, 2225], 'Gil': [819, 2227], 'Bartrons': [821, 1010, 2229, 4885, 5010], 'Cytogenet.': [823, 2231], 'Cell': [824, 2232], 'Genet.': [825, 2233, 5497], '83:': [827, 2235], '214-217Crossref': [828, 2236], '(65)': [831, 2239], 'These': [834, 2194, 2424, 2506, 3084, 3727, 4144, 5303], 'isoenzymes': [835], 'differ': [836], 'not': [837, 1661, 4061, 4098, 4128, 4921, 5090, 5108, 5326], 'only': [838, 5328], 'tissue': [841], 'distribution': [842], 'but': [843, 4647], 'kinetic': [847], 'properties.': [850], 'isozyme': [853], 'highest': [856, 3945], 'kinase:phosphatase': [857, 3946], 'activity': [858, 953, 1279, 4810], 'ratio': [859], 'thus': [861, 4552, 5519], 'maintains': [862], 'levels,': [865, 4307], 'turn': [868, 1159], 'sustains': [869], 'high': [870, 946, 1058, 1840, 3966, 4092], '10Sakakibara': [907, 4006], 'Okamura': [911, 4010], 'N.': [912, 918, 1912, 2050, 2846, 2909, 3061, 3115, 3452, 3622, 4011, 4017, 4171, 4699, 4979, 4985, 5583], 'Nakagawa': [913, 4012], 'Komada': [915, 4014], 'Tominaga': [917, 4016], 'Shimojo': [919, 4018], 'M': [920, 4019], '1997;': [925, 1121, 1366, 4024, 4411], '122:': [926, 4025], '122-128Crossref': [927, 4026], '(102)': [930, 4029], 'Significantly,': [933], 'this': [934, 1050, 1704, 1856, 2262, 2293, 2645, 4754, 5558], 'isoform': [935, 3952, 4069, 5201], 'constitutively': [937, 1269], 'expressed': [938, 1270, 2314, 3955, 5410], 'several': [940, 1181, 1681, 4033, 4083, 4585, 4948, 5028], 'human': [941, 1682, 2155, 2205, 2271, 2391, 2435, 2554, 2663], 'cancer': [942], 'cell': [943, 1685, 1692, 1800, 1901, 1945, 2034, 2118, 2900, 3244, 3594, 3725, 4084, 5169], 'lines': [944, 1693, 2035], 'having': [945], 'proliferative': [947], 'require': [950], '5-phosphoribosyl-1-pyrophosphate,': [961], 'precursor': [963], 'purines': [965], 'pyrimidines': [967], '11Boada': [1002], 'Roig': [1004], 'Gamez': [1008], 'Cascante': [1012], 'Bermudez': [1014], 'FEBS': [1016], 'Lett.': [1017], '2000;': [1018, 1041, 1145, 1312, 1832, 1887, 3155, 3270, 4211, 4992, 5069, 5298, 5372, 5397, 5448, 5474], '480:': [1019], '261-264Crossref': [1020], '(48)': [1023], '12Hirata': [1026], 'Watanabe': [1028], 'Miura': [1030], 'Ijichi': [1032], 'Biosci.': [1038], 'Biotechnol.': [1039], '2047-2052Crossref': [1043], '(17)': [1046], 'Thus,': [1049], 'serve': [1052], 'explanation': [1055, 5522], 'present': [1061, 4822, 4956], 'transformed': [1063, 3957], 'even': [1065, 5412], 'Hypoxia': [1073], 'potent': [1076, 3831, 5142], 'inducer': [1077], 'expression.': [1080, 3561, 4837], 'important': [1085], 'component': [1086], 'including': [1091, 5340], 'metastasis': [1095], '(13Maxwell': [1096], 'P.H.': [1097, 3462, 3680, 4601, 4709, 5438], 'Dachs': [1098], 'G.U.': [1099], 'Gleadle': [1100, 3431, 4678], 'J.M.': [1101, 1140, 1446, 1590, 1827, 1882, 3265, 3432, 4489, 4679, 5466, 5489], 'Nicholls': [1102], 'L.G.': [1103], 'Harris': [1104, 5443], 'A.L.': [1105, 5444], 'Stratford': [1106], 'Hankinson': [1108], 'O.': [1109, 5536], 'Pugh': [1110, 1195, 1483, 1626, 3463, 3528, 3628, 3693, 4526, 4614, 4710, 4792, 5439], 'C.W.': [1111, 1196, 3464, 3627, 3629, 3694, 4615, 4711, 5440], 'Ratcliffe': [1112, 1197, 1486, 1629, 1730, 3174, 3467, 3531, 3630, 3697, 4230, 4529, 4618, 4714, 4795, 5441, 5562], 'PJ': [1113], '94:': [1122], '8104-8109Crossref': [1123], '(942)': [1126], '14Ryan': [1129], 'H.E.': [1130, 1817, 1872, 3255], 'Poloni': [1131, 1818, 1873, 3256], 'McNulty': [1133, 1820, 1875, 3258], 'W.': [1134, 1438, 1485, 1582, 1628, 1821, 1876, 3259, 3530, 4481, 4528, 4794], 'Elson': [1135, 1822, 1877, 3260], 'Gassmann': [1137, 1291, 1824, 1879, 3262, 5278], 'Arbeit': [1139, 1826, 1881, 3264], 'Johnson': [1141, 1807, 1828, 1883, 3266, 4329, 5572], 'R.S.': [1142, 1829, 1884, 3267, 4330], 'Cancer': [1143, 1830, 1885, 3268], '60:': [1146, 1833, 1888, 3271], '4010-4015PubMed': [1147, 1834, 1889, 3272], 'In': [1150, 1244, 5094, 5405], 'conditions,': [1152, 4370], 'oxidative': [1154, 3822, 4134], 'impaired,': [1157], 'meet': [1163], 'demands': [1166], 'Pasteur': [1168], 'adaptive': [1172, 5206], 'encoding': [1180], '(15Firth': [1191], 'J.D.': [1192], 'Ebert': [1193], 'B.L.': [1194], 'P.J.': [1198, 1380, 1487, 1630, 3175, 3468, 3532, 3631, 3698, 4231, 4425, 4530, 4619, 4715, 4796, 5442], '1994;': [1206, 2573, 2761], '91:': [1207], '6496-6500Crossref': [1208], '(443)': [1211], '16Semenza': [1214], 'G.L.': [1215, 1309, 2014, 5066, 5295, 5472], 'Jiang': [1216, 2008], 'B.-H.': [1217], 'Leung': [1218], 'S.W.': [1219], 'Passantino': [1220], 'Concordet': [1222], 'J.-P.': [1223], 'Maire': [1224], 'P.': [1225, 1462, 1605, 2048, 3456, 3507, 4326, 4505, 4703, 4771, 5386], 'Giallongo': [1226], '271:': [1232, 2023], '32529-32537Abstract': [1233], '(1339)': [1241], 'animals,': [1245], 'complex': [1251, 1263, 1526, 3361, 3370, 4846, 5251], 'mediates': [1252, 4847], 'activation': [1254, 4248, 4849, 5247, 5314], 'these': [1256, 3498, 3759, 4924], 'heterodimeric': [1261], 'protein': [1262, 1418, 1430, 1522, 1870], 'composed': [1264], 'two': [1266, 3592, 4925], 'subunits:': [1267], 'β-subunit,': [1271], 'controlled': [1281, 5153], 'concentration': [1285, 1996], '(reviewed': [1286], 'Refs.': [1288], '17Wenger': [1289], 'R.H.': [1290, 5277], 'Storey': [1293, 5280], 'K.B.': [1294, 5281], 'Environmental': [1295, 5282], 'Stress': [1296, 5283], 'Gene': [1298, 5285], 'Regulation.': [1299, 5286], 'BIOS': [1300, 5287], 'Scientific': [1301, 5288], 'Publishers': [1302, 5289], 'Ltd.,': [1303, 5290], 'Oxford1999:': [1304, 5291], '25-45Google': [1305, 5292], 'Scholar': [1306], '18Semenza': [1308, 5294], 'Genes': [1310, 5067, 5296], 'Dev.': [1311, 5068, 5297], '14:': [1313, 5070, 5299], '1983-1991PubMed': [1314, 5071, 5300], 'normoxia,': [1318], 'HIF-1α': [1319, 1412, 1547, 1861, 1867, 2002, 3252, 3278, 3303, 3321, 3365, 3380, 3384, 3412, 3502, 3600, 3612, 4275, 4283, 4542, 4670, 5361, 5407], 'rapidly': [1321, 4375], 'degraded': [1322, 4376], 'ubiquitin': [1325, 1543, 4550], 'proteasome': [1326, 4379], 'system,': [1327], 'whereas': [1328, 3367], 'exposure': [1329, 4072, 4110], 'prevents': [1333], '(19Huang': [1336, 4381], 'L.E.,': [1337, 4382], 'Gu,': [1338, 4383], 'Schau': [1340, 4385], 'Bunn': [1342, 4387], 'H.F.': [1343, 1476, 1619, 3521, 4388, 4519, 4785], '95:': [1352, 4397], '7987-7992Crossref': [1353, 4398], '(1835)': [1356, 4401], '20Salceda': [1359, 4404], 'Caro': [1361, 1917, 2569, 2757, 2851, 2914, 3066, 3120, 4176, 4406, 5391], '272:': [1367, 4412], '22642-22647Abstract': [1368, 4413], '(1393)': [1376, 4421], '21Kallio': [1379, 4424], 'Wilson': [1381, 1467, 1610, 3445, 3512, 4426, 4510, 4692, 4776], 'W.J.': [1382, 4427], "O'Brien": [1383, 4428], 'Makino': [1385, 4430], 'Poellinger': [1387, 4432], '274:': [1393, 4438], '6519-6525Abstract': [1394, 4439], '(686)': [1402, 4447], 'enzymatic': [1406, 4809], 'hydroxylation': [1407, 1556, 3402, 3613, 4462, 4565], 'proline': [1409], '564': [1410], 'controls': [1413, 3924], 'turnover': [1415], 'it': [1421, 3650, 3961, 4554], 'interaction': [1423, 3644], '(VHL)': [1429], '(22Ivan': [1431, 1575, 4474], 'Kondo': [1433, 1577, 4476], 'Yang': [1435, 1579, 4478, 5486], 'H.': [1436, 1580, 4320, 4479, 5434, 5464, 5487], 'Kim': [1437, 1581, 4480], 'Valiando': [1439, 1583, 4482], 'Ohh': [1441, 1585, 4484, 5484], 'Salic': [1443, 1587, 4486], 'Asara': [1445, 1589, 4488], 'Lane': [1447, 1591, 4490, 5385], 'W.S.': [1448, 1592, 4491], 'Kaelin': [1449, 1593, 4492, 5492], 'W.G.,': [1450, 1594, 4493, 5493], 'Jr.': [1451, 1595, 4494, 5494], 'Science.': [1452, 1488, 1596, 1631, 3487, 3533, 4495, 4531, 4734, 4797, 5537], '292:': [1454, 1490, 1598, 1633, 3535, 4497, 4533, 4799], '464-468Crossref': [1455, 1599, 4498], '(3842)': [1458, 1602, 4501], '23Jaakkola': [1461, 4504], 'Mole': [1463, 1606, 3439, 3508, 4506, 4686, 4772], 'D.R.': [1464, 1607, 3440, 3509, 4507, 4687, 4773], 'Tian': [1465, 1608, 3449, 3510, 4508, 4696, 4774], 'Y.M.': [1466, 1609, 3511, 4509, 4775], 'M.I.': [1468, 1611, 3446, 3513, 4511, 4693, 4777], 'Gielbert': [1469, 1612, 3514, 4512, 4778], 'Gaskell': [1471, 1614, 3516, 4514, 4780], 'Kriegsheim': [1473, 1616, 3518, 4516, 4782], 'A.V.': [1474, 1617, 3519, 4517, 4783], 'Hebestreti': [1475, 1618, 3520, 4518, 4784], 'Mukherju': [1477, 1620, 3522, 4520, 4786], 'Schofield': [1479, 1622, 3465, 3524, 4522, 4712, 4788], 'C.J.': [1480, 1623, 3466, 3525, 4523, 4713, 4789], 'Maxwell': [1481, 1624, 3461, 3526, 3625, 4524, 4708, 4790, 5437], 'Ph.H.': [1482, 1625, 3527, 4525, 4791], 'C,': [1484, 1535, 1627, 3529, 4527, 4793], '468-472Crossref': [1491, 1634, 3536, 4534, 4800], '(4391)': [1494, 1637, 3539, 4537, 4803], '24Yu': [1497], 'White': [1499], 'S.B.': [1500], 'Zhao': [1501], 'Q.': [1502], 'Lee': [1503], 'F.S.': [1504], '98:': [1513, 3178, 4234], '9630-9636Crossref': [1514], '(638)': [1517], 'VHL': [1521, 3732, 3740, 3789, 4562, 4656, 5421], 'forms': [1523, 4904], 'multiprotein': [1525], 'contains,': [1528], 'at': [1529, 2736, 2745, 2786, 2804, 3020, 3614, 3618, 3807, 3811, 4871, 5027, 5041], 'minimum,': [1531], 'elongins': [1532], 'B': [1533], 'Cul2,': [1536], 'Rbx,': [1538], 'acts': [1540, 4547], 'ligase': [1544], 'targets': [1546, 3649], 'effect': [1551, 3034, 5098], 'Pro-564': [1555, 3404], 'mimicked': [1559, 4108], 'transition': [1561, 4118], 'metals': [1562], 'like': [1563], 'cobalt,': [1564, 1669, 2987], 'iron': [1565, 1671, 4113, 4761], 'chelators': [1566, 1672], 'inhibitors': [1569, 4576], 'Scholar,23Jaakkola': [1604], 'Despite': [1640], 'importance': [1642], 'regulating': [1644], 'mammals': [1659], 'characterized.': [1663, 4063, 4862], 'We': [1664, 3542, 4557, 5546, 5591], 'report': [1665], 'here': [1666, 4244], 'produce': [1673, 3737], 'significant': [1675, 4077, 4830], 'mRNA': [1679, 1868, 2809, 2823, 2973, 2995, 3006, 3312, 3560, 3580, 3716, 4081, 4836, 5106], 'lines.': [1686, 3595, 4085], 'utilizing': [1689], 'conditional': [1690, 3248], 'knock-out': [1691], 'HIF-1αgene,': [1696], 'demonstrate': [1698, 4070, 4824], 'inducibility': [1702], 'presence': [1710, 3378, 4257], 'active': [1713, 4260], 'complex.': [1715, 4367], 'Cobalt': [1716], 'chloride': [1717], 'desferrioxamine': [1719, 2968, 2989, 3016, 3038, 4115], 'were': [1720, 1778, 1802, 1904, 1950, 1963, 2062, 2115, 2140, 2668, 2713, 2731, 2771, 2975, 3281, 3317, 3326], 'purchased': [1721], 'from': [1722, 1738, 1746, 1763, 1804, 2032, 2174, 2261, 2404, 2486, 2872, 2892, 2935, 2944, 2955, 3821, 4917, 5046], 'Sigma.': [1723], 'Dimethyloxalylglycine': [1724], 'gift': [1727], 'Peter': [1729, 5561], '(Oxford,': [1731], 'UK).': [1732], 'Fetal': [1733], 'calf': [1734], 'serum': [1735], 'obtained': [1737, 1803], 'HyClone': [1739], '(Logan,': [1740], 'UT).': [1741], '[32P]UTP': [1742], '(800': [1743], 'Cu/mmol)': [1744], 'PerkinElmer': [1747], 'Life': [1748], 'Sciences.': [1749], 'T3': [1750, 2696], 'T7': [1752, 2694], 'RNA': [1753, 2029, 2129, 2138, 2173, 2339, 2403, 2485, 2598, 2697, 2712, 2831], 'polymerases,': [1754], 'RNase': [1755, 2978, 3294], 'inhibitor,': [1756], 'DNase': [1758], 'I': [1759], '(Rnase': [1760], 'free)': [1761], 'where': [1762, 2836], 'Roche': [1764, 2691], 'Molecular': [1765, 2700], 'Biochemicals.': [1766], 'Human': [1767], 'hepatoma': [1768], 'Hep-3B': [1769, 2175, 2998], 'RPE': [1772], '(human': [1773], 'retinal': [1774], 'pigment': [1775], 'epithelial)': [1776], 'grown': [1779, 1838], 'minimum': [1781], 'essential': [1782, 5556], 'medium': [1783, 1845], 'supplemented': [1784, 1846], 'pyruvate,': [1786], '10–15%': [1787], 'fetal': [1788, 1849], 'bovine': [1789, 1850], 'serum,': [1790], 'penicillin,': [1791], 'streptomycin.': [1793], 'Mouse': [1794], '(wild-type': [1797], 'HIF-1α-deficient': [1799], 'lines)': [1801], '(University': [1808, 5563, 5573], 'California,': [1810, 5575], 'San': [1811, 5576], 'Diego,': [1812], 'La': [1813, 2281], 'Jolla,': [1814, 2282], 'CA)': [1815, 2283], '(14Ryan': [1816, 1871, 3254], 'Scholar)': [1836, 2868, 4805], "Dulbecco's": [1842], 'modified': [1843], "Eagle's": [1844], '10%': [1848], 'serum.': [1851], 'Western': [1852, 2896, 3605], 'blot': [1853, 3606], 'analysis': [1854, 3607, 4745, 4930], 'shown': [1863, 2982, 3002, 3186, 3298, 3563, 3603, 3665, 3743, 4137, 4280, 5306], 'absence': [1865, 3795, 4132], 'Mitochondrial': [1892], 'DNA-less': [1893], '(143B206)': [1894], 'ρο': [1895], 'parental': [1899, 3196], 'osteosarcoma': [1900], 'line': [1902, 1946, 3245], '(143B)': [1903], 'described': [1905, 2042, 2562, 2610, 2749, 2840, 2903, 4665], 'previously': [1906, 2750], '(25Srinivas': [1907, 2841, 2904, 3056, 3110, 4166], 'V.': [1908, 2842, 2905, 3057, 3111, 4167], 'Leshchinsky': [1909, 2843, 2906, 3058, 3112, 4168], 'I.': [1910, 2844, 2907, 3059, 3113, 4169], 'Sang': [1911, 2845, 2908, 3060, 3114, 4170], 'King': [1913, 2847, 2910, 3062, 3116, 4172], 'Minchenko': [1915, 2849, 2912, 3064, 3118, 4174], '21995-21998Abstract': [1924, 2858, 2921, 3073, 3127, 4183], '(130)': [1932, 2866, 2929, 3081, 3135, 4191], 'pVHL-deficient': [1936, 3721, 4572], '786-0': [1937, 3722, 3764, 4631, 5589], 'renal': [1938, 3723], 'carcinoma': [1939, 3724], 'stable': [1943, 3767], 'transfectant': [1944], 'expressing': [1947, 3772], 'wild-type': [1948], 'pVHL': [1949, 3662, 3713, 3777], 'provided': [1951, 5551], 'Nikolai': [1953], 'Kley': [1954, 5584], '(Bristol-Myers': [1955, 5585], 'Squibb).': [1956], 'For': [1957, 2704, 2951], 'treatment,': [1959], 'culture': [1961], 'plates': [1962], 'placed': [1964], '6': [1966, 3286, 3570], 'h': [1967, 2744, 2785, 3012, 3571], 'modular': [1970], 'incubator': [1971], 'chamber': [1972], '(Billup-Rothenburg,': [1973], 'Forma': [1974], 'Scientific,': [1975], 'Marietta,': [1976], 'OH)': [1977], 'flushed': [1979], 'gas': [1982], 'mixture': [1983, 2113], 'containing': [1984, 2727, 4870], '0.5%': [1985], 'oxygen,': [1986], '5%': [1987], 'dioxide,': [1989], '94%': [1991], 'nitrogen.': [1992], 'low': [1994], 'chosen': [1998], 'obtain': [2000], 'maximal': [2001, 3019], 'stimulation,': [2004], 'reported': [2006, 4900], 'et': [2009], 'al.': [2010], '(42Jiang': [2011], 'B.H.': [2012], 'Semenza': [2013, 5471], 'Bauer': [2015, 2565, 2753], 'Marti': [2017], 'H.H.': [2018], 'Am.': [2019, 5445], 'Physiol.': [2021], 'C1172-C1180Crossref': [2024], 'Total': [2028], 'extracted': [2031, 2063], 'cultured': [2033], 'using': [2036, 2171, 2186, 2251, 2284, 2335, 2401, 2416, 2483, 2498, 2594, 2693, 2812, 2869, 3292, 4270, 4571], 'guanidinium-phenol-chloroform': [2039], 'extraction': [2040], 'method': [2041], 'Chomczynski': [2044], 'Sacchi': [2046, 2049], '(26Chomczynski': [2047], 'Anal.': [2051], '1987;': [2053], '162:': [2054], '156-159Crossref': [2055], '(63084)': [2058], 'Cells': [2061, 3659], '2': [2065, 2095, 2101, 2784, 3011, 3352, 3393], 'ml': [2066, 2093, 2102, 2108], 'guanidine': [2068], 'isothiocyanate': [2069], 'solution': [2070], '(UltraPure)': [2071], '(4': [2072], 'mguanidine': [2073], 'isothiocyanate,': [2074], '50': [2075, 2787], 'mm': [2076, 2081], 'Tris-HCl': [2077], '(pH': [2078], '7.5),': [2079], '25': [2080, 2720], 'EDTA,': [2082], '0.1': [2084], 'm': [2085, 2096], '2-mercaptoethanol)': [2086], 'directly': [2087], 'plates.': [2090], 'Sequentially,': [2091], '0.2': [2092], 'sodium': [2097], 'acetate,': [2098], 'pH': [2099], '4.0,': [2100], 'phenol': [2104], '(water-saturated),': [2105], '0.4': [2107], 'chloroform-isoamyl': [2111], 'alcohol': [2112], '(49:1)': [2114], 'added': [2116], 'lysate': [2119], 'thorough': [2121], 'mixing': [2122], 'after': [2123], 'addition': [2125], 'each': [2127, 2822], 'reagent.': [2128], 'precipitated': [2131], 'equal': [2134], 'volume': [2135], '2-propanol.': [2137], 'pellets': [2139], 'washed': [2141], '75%': [2143], 'ethanol': [2144], 'dissolved': [2146, 2718], 'nuclease-free': [2148], 'water.': [2149], 'plasmid': [2151, 2248, 2263, 2294, 2374, 2452, 2465, 2533, 2537, 2579, 2646, 3771], '3': [2157, 3610], '(PFKFB3)': [2158], 'probe': [2159, 2303, 2309, 2334, 2388, 2393, 2471, 2550, 2586, 2655, 2769, 2880], 'ribonuclease': [2161, 2305, 2473, 2556, 2705], 'protection': [2162, 2306, 2474, 2557, 2706, 2979, 3295], 'assay': [2163, 2558, 2886, 3391], 'created': [2165, 2395, 2477, 2588, 5241], 'cDNA': [2170, 2183, 2273, 2400, 2413, 2482, 2495, 2529, 2593], 'total': [2172, 2338, 2402, 2484, 2597, 2664, 2711, 2899], 'oligo(dT)': [2178, 2408, 2490], 'followed': [2179, 2409, 2491, 2602], 'cloning.': [2181, 2411, 2493], 'amplified': [2185, 2415, 2497], 'forward': [2187, 2343, 2417, 2499], 'primer': [2188, 2192, 2344, 2348, 2418, 2422, 2500, 2504, 2601], '(5′-GGCCGCATCGGGGGCGACTC-3′)': [2189], 'reverse': [2191, 2347, 2421, 2503, 2600], '(5′-TTGCGTCTCAGCTCAGGGAC-3′).': [2193], 'oligonucleotides': [2195, 2425, 2507, 2613], 'correspond': [2196, 2350, 2426, 2508, 2615], 'nucleotide': [2198, 2266, 2352, 2428, 2510, 2617], 'sequences': [2199, 2267, 2353, 2429, 2511, 2618, 4916, 5023], '901–920': [2200], '2250–2231': [2202], 'cDNA,': [2207, 2361, 2437, 2519, 2607], 'respectively': [2208, 2362, 2438, 2520, 2627], '(GenBankTM': [2209, 2363, 2439, 2521], 'accession': [2210, 2364, 2440, 2522], 'number': [2211, 2365, 2441, 2523, 2629], 'NM004566)': [2212], '(9Manzano': [2213], 'PCR': [2243, 2369, 2525], 'fragment': [2244, 2260, 2370, 2526, 2633], 'cloned': [2246, 2372, 2531], 'into': [2247, 2276, 2373, 2447, 2532, 2636], 'pCR': [2249, 2375, 2534], 'II-TOPO': [2250, 2376], 'TOPO': [2252], 'TA': [2253], 'Cloning': [2254], 'Kit': [2255], '(Invitrogen,': [2256], 'Carlsbad,': [2257], 'CA).': [2258, 2819, 2950], 'AnEcoRI-Eco47III': [2259], 'corresponding': [2264, 3792], '901–1218': [2268], 'recloned': [2275, 2635], 'pBluescript': [2277, 2448, 2637], 'II': [2278, 2449, 2638], 'KS+': [2279], '(Stratagene,': [2280], 'EcoRI': [2285], 'EcoRV': [2287], 'sites.': [2288], 'Following': [2289, 2443, 4540], 'digestion': [2290, 2379, 2642], 'XbaI,': [2292, 2644], 'utilized': [2296, 2327, 2383, 2551, 2614, 2648, 2898, 3240, 3543, 3719], 'create': [2298, 2458], '419-base': [2300], 'radiolabeled': [2301, 2461, 2546, 2653, 2686, 2879], 'antisense': [2302, 2462, 2547, 2654], 'assay.': [2307, 3296], 'recognizes': [2310], 'common': [2312], 'region': [2313, 4934, 5034], 'inducible': [2318, 4903], 'ubiquitous': [2320], 'isoforms.': [2322, 4926], 'similar': [2324, 3024], 'procedure': [2325], 'spleen': [2337], 'template.': [2341], '(5′-GGCAAGATTGGGGGCGACTC-3′)': [2345], '(5′GGCTCCAGGCGTTGGACAAG-3′)': [2349], '1112–1131': [2354], '1440–1421': [2356], 'AF294617).': [2366], 'final': [2368], 'following': [2378, 2641, 2690, 3013], 'BamHI': [2381], 'generation.': [2389], 'Glut-1': [2392, 2412, 2436, 2470, 2494, 2518, 2528, 2994, 3031, 3330, 3579, 3678, 4351, 4641, 4835, 5064], 'HeLa': [2405, 3221, 4087], '(5′-CCATGGAGCCCAGCAGCAAG-3′)': [2419, 2501], '(5′-ATGGCAGCTGGACGTGGACC-3′).': [2423], '178–197': [2430], '1390–1371': [2432], 'NM006516).': [2442], 'cloning': [2444, 2604], 'insertion': [2446], 'KS+,': [2450], 'digested': [2454, 2539], 'XbaI': [2456], '478-base': [2460], 'probe.': [2463, 2548], 'assays': [2475, 2835], 'lungs': [2488], '(5′-CACACCGATGATGAAGCGGC-3′).': [2505], '188–207': [2512], '582–563': [2514], 'M23384).': [2524], 'II-TOPO.': [2535], 'HindIII': [2541], 'make': [2543], '443-base': [2545], 'VEGF': [2555, 3332, 3676, 3754], 'already': [2561, 2839], '(27Minchenko': [2563, 2751], 'Salceda': [2567, 2755], 'Lab.': [2571, 2759], 'Invest.': [2572, 2760], '71:': [2574, 2762], '374-379PubMed': [2575, 2763], '18': [2584, 2624, 2828, 3021], 'S': [2585, 2625, 2829], 'lung': [2596], 'essentially': [2608], 'above.': [2611], '233–251': [2619], '860–843': [2621], 'rRNA,': [2626], '(GenBankTMaccession': [2628], 'X00686).': [2630], 'PstI-XbaI': [2632], 'SK+,': [2639], 'generate': [2650, 5225], '435-base': [2652], 'used': [2658, 2881], 'analyze': [2660], 'RNA.': [2665], 'All': [2666], 'constructs': [2667], 'verified': [2669], 'sequencing': [2671, 2777], 'inserts': [2673], 'found': [2675, 5026, 5056, 5531], '100%': [2678], 'identical': [2679], 'published': [2682], 'sequences.': [2683], 'Synthesis': [2684], 'probes': [2687], 'performed': [2689, 2837], 'protocols': [2692], 'or': [2695, 5423], 'polymerase': [2698], '(Roche': [2699], 'Biochemicals)': [2701], '[α32P]UTP.': [2703], 'assays,': [2707, 2953], 'water': [2708], 'solutions': [2709], 'dried': [2714, 2793], 'vacuum': [2716], 'μl': [2721], '80%': [2723], 'formamide': [2724], 'hybridization': [2725], 'buffer': [2726, 2782], 'labeled': [2728], 'probes.': [2729], 'Samples': [2730], 'preincubated': [2732], '5': [2734], 'min': [2735], '85': [2737], '°C': [2738, 2747], 'then': [2740, 2792], 'incubated': [2741], '16': [2743, 4873], '45': [2746], 'extracted,': [2767], 'protected': [2768], 'fragments': [2770], 'run': [2772], '6%': [2775], 'polyacrylamide': [2776], 'gel': [2778, 2790, 2884, 3348], '1×': [2780], 'Tris-borate-EDTA': [2781], 'mA.': [2788], 'exposed': [2795, 3282], 'x-ray': [2797], 'film': [2798], '(Hyperfilm': [2799], 'MP,': [2800], 'Amersham': [2801], 'Biosciences,': [2802], 'Inc.)': [2803], '−70': [2805], '°C.': [2806], 'Expression': [2807], 'quantified': [2811], 'storage': [2813], 'phosphor': [2814], 'technology': [2815], '(Molecular': [2816], 'Dynamics,': [2817], 'Sunnyvale,': [2818], 'Intensity': [2820], 'band': [2824], 'normalized': [2826], 'ribosomal': [2830], 'level.': [2832, 3814], 'Gel': [2833], 'nuclear': [2870], 'extracts': [2871, 2901], 'normoxic': [2873, 3504, 4369, 5414], 'cells.': [2876, 2999, 3323, 3376, 5121, 5258, 5590], '18-mer': [2878], 'contained': [2887], 'HRE': [2889, 5022, 5055], 'consensus': [2890, 5054], 'sequence': [2891], 'erythropoietin': [2894], 'gene.': [2895, 4853, 5037], 'blots': [2897], 'Anti-HIF-2α': [2932], 'antibody': [2933, 2942], 'Novus': [2936, 2956], 'Biologicals': [2937, 2957], '(Littleton,': [2938], 'CO),': [2939], 'antiVHL': [2941], 'Santa': [2945], 'Cruz': [2946], 'Biotechnology': [2947], '(Santa': [2948], 'Cruz,': [2949], 'supershift': [2952, 3390], 'anti-HIF-1α': [2954], 'utilized.': [2959], 'To': [2960, 3225, 3708], 'examine': [2961, 3552], 'effects': [2963, 3325, 3554], 'expression,': [2972, 3717, 4096], 'measured': [2976], 'assays.': [2980], 'As': [2981, 3185, 3297, 3562, 3596, 3742], 'Fig.1': [2984, 3004, 3188], 'a,': [2985, 3301, 3566, 3746], 'greatly': [2990], 'stimulated': [2991], 'b,': [3005], 'accumulation': [3007, 3575], 'visible': [3009], 'treatment': [3014, 3568], 'h.': [3022], 'pattern': [3025], 'seen': [3029, 3318, 3372], 'mRNA.': [3032], 'tested': [3041], 'ρo': [3043, 3190], 'mitochondrial': [3047, 4148, 4261], 'DNA': [3048, 4149], 'no': [3051, 3214, 3315, 3368], 'functional': [3052, 3739, 4365, 4655], 'respiratory': [3053, 4262], 'electron': [3054], 'transport': [3055], 'depend': [3086, 4151], 'exclusively': [3087, 4152], 'needs,': [3093], 'there': [3095], 'conflicting': [3098, 4157], 'reports': [3099], 'abnormal': [3109], '28Chandel': [3138, 4194], 'N.S.': [3139, 4195], 'McClintock': [3140, 4196], 'D.S.': [3141, 4197], 'Feliciano': [3142, 4198], 'C.E.': [3143, 4199], 'Wood': [3144, 4200], 'T.M.': [3145, 4201], 'Melendez': [3146, 4202], 'J.A.': [3147, 4203], 'A.M.': [3149, 4205], 'Schumacker': [3150, 4206], 'P.T.': [3151, 4207], '275:': [3156, 4212, 5373], '25130-25138Abstract': [3157, 4213], '(1532)': [3165, 4221], '29Vaux': [3168, 4224], 'E.C.': [3169, 3688, 4225, 4609], 'Metzen': [3170, 3443, 4226, 4690], 'Yeats': [3172, 4228], 'K.M.': [3173, 4229], 'Blood.': [3176, 4232], '296-302Crossref': [3179, 4235], '(178)': [3182, 4238], 'c,': [3189], 'cells,': [3191, 3198, 3958, 4088, 4145, 4358], 'control': [3197, 3364, 3837], 'Unexpectedly,': [3213], 'observed': [3219, 3327, 3969], '(not': [3223], 'shown).': [3224], 'test': [3226, 3709], 'gene,': [3238], 'fibroblast': [3243], 'deletion': [3249], 'Wild-type': [3275], 'negative': [3279, 3322, 3375], 'h,': [3287], 'analyzed': [3291], 'Fig.2': [3300], 'although': [3302], 'positive': [3304], 'substantial': [3308], 'changes': [3316], 'Similar': [3324], 'genes,': [3333], 'known': [3341], 'HIF-1.': [3346], 'Fig.': [3351, 3609, 3779], 'b': [3353], 'shows': [3354], '(+),': [3366], '(+)': [3385], '(Fig.': [3392], 'b).': [3394], 'Oxygen': [3395], 'sensing': [3396], 'mediated': [3398, 3417], 'ODD': [3407], '(oxygen-dependent': [3408], 'degradation)': [3409], 'domain': [3410], 'protein.': [3413, 3741, 4657], 'reaction': [3415], 'specific': [3419, 4470], 'iron-dependent': [3420], 'hydroxylases,': [3422], 'utilize': [3424], 'oxoglutarate': [3425, 4763], 'co-substrate': [3428], '(30Epstein': [3429, 4676], 'A.C.R.': [3430, 4677], 'McNeill': [3433, 4680], 'L.A.': [3434, 4681], 'Hewitson': [3435, 4682], 'K.S.': [3436, 4683], "O'Rourke": [3437, 4684], 'Mukherji': [3441, 4688], 'Dhanda': [3447, 4694], 'Y.-M.': [3450, 4697], 'Masson': [3451, 4698], 'Hamilton': [3453, 4700], 'D.L.': [3454, 4701], 'Jaakkola': [3455, 4702, 4767], 'Barstead': [3457, 4704], 'Hodgkin': [3459, 4706], 'Cell.': [3469, 4332, 4716], '107:': [3471, 4718], '43-54Abstract': [3472, 4719], '(2703)': [3480, 4727], '31Bruick': [3483, 4730], 'R.K.': [3484, 4731], 'McKnight': [3485, 4732], 'S.L.': [3486, 4733], '294:': [3489, 4736], '1337-1340Crossref': [3490, 4737], '(2091)': [3493, 4740], 'Inhibition': [3496], 'induce': [3501], '(23Jaakkola': [3506, 4770], 'dimethyloxalylglycine,': [3544], 'cell-permeable': [3546], 'competitive': [3547, 4575], 'oxoglutarate,': [3550], 'inhibition': [3557], 'PFKBF3': [3559], 'Fig.3': [3565], 'dimethyloxalylglycine': [3567, 3598], 'results': [3572, 4158, 4242, 4827, 4839, 5260], 'degree': [3583], 'equivalent': [3584], 'produced': [3587, 4075], 'stimulation': [3590], 'expected,': [3597], 'stimulates': [3599], 'b.': [3611], 'Pro-564,': [3615], 'possibly': [3617, 4466], 'others': [3619], 'residues': [3620], '(32Masson': [3621], 'William': [3623], 'P.H.,': [3626], 'EMBO': [3632], '20:': [3635], '5197-5206Crossref': [3636], '(849)': [3639], 'Scholar),': [3641], 'facilitates': [3642], 'pVHL,': [3646, 4545], 'ultimately': [3648], 'ubiquitination': [3652], 'proteasomal': [3657], 'system.': [3658], 'deficient': [3660, 4272], 'over-express': [3667], 'HIF-α': [3668, 4598], 'proteins': [3669, 4599], 'up-regulate': [3671], '(33Maxwell': [3679, 4600], 'Wiesner': [3681, 4602], 'M.D.': [3682, 4603], 'Chang': [3683, 4604], 'G.W.': [3684, 4605], 'Clifford': [3685, 4606], 'S.C.': [3686, 4607], 'Vaux': [3687, 4608], 'Cockman': [3689, 4610], 'M.E.': [3690, 4611], 'Wykoff': [3691, 4612], 'C.C.': [3692, 4613], 'Maher': [3695, 4616], 'E.R.': [3696, 4617], 'Nature.': [3699, 4620], '399:': [3701, 4622], '271-275Crossref': [3702, 4623], '(4087)': [3705, 4626], 'line.': [3726], 'contain': [3729], 'missense': [3731], 'mutation': [3733], 'fail': [3735], 'Fig.4': [3745], '(−)': [3748, 3790], 'overexpress': [3750, 4584], 'Glut-1,': [3752], 'messengers.': [3755], 'attenuated': [3762], 'transfection': [3768], 'wild': [3774], 'form': [3775], '(+).': [3778], '4': [3780], 'bshows': [3781], 'pHIF-2α': [3786], 'pVHL.': [3797], 'organism': [3803], 'systemic': [3809], 'cellular': [3813], 'When': [3815], 'becomes': [3817], 'limited,': [3818], 'switch': [3820], 'anaerobic': [3825], 'Fructuose-2,6-biphosphate': [3827], 'most': [3830, 3953, 5058, 5141], 'exerts': [3836], 'over': [3838], '4Pilkis': [3894], 'allosterically': [3914, 5124], 'activates': [3915, 5333], 'PFK-1': [3916], 'inhibits': [3918], 'gluconeogenic': [3920], 'fructuose-1,6-bisphosphatase.': [3922], 'Fru-(2,6)-P2': [3928], 'catalyzing': [3930], 'Among': [3935], 'isoforms': [3938], 'mammalian': [3940, 5120], 'origin,': [3941], 'activity.': [3947, 4766], 'suggesting': [3959], 'may': [3962, 5516], 'contribute': [3963], 'tumors': [3971], 'Although': [4032], 'studies': [4034, 4065, 4823], 'demonstrated': [4036, 4757], 'some': [4042], 'activated': [4051, 5125], 'during': [4052, 5211], 'Our': [4064, 4912, 5191], 'increase': [4078, 5271], 'However,': [4086, 5074], 'basal': [4093, 4635], 'level': [4094], 'did': [4097], 'responses': [4100, 4163], 'hypoxia.': [4102], 'chelator': [4114], 'metal': [4119], 'cobalt.': [4120], 'thePFKFB3': [4125, 4857], 'affected': [4129], 'phosphorylation,': [4135], 'ρocells.': [4143], 'glycolysis,': [4154], 'yielded': [4156], 'respect': [4160], 'presented': [4243], 'confirm': [4245], 'independent': [4254], 'chain.': [4263], 'investigated': [4269], 'subunit.': [4276], '(−/−)': [4284, 4357], 'decreased': [4287, 4308, 4313], 'impaired': [4296], '(Pasteur': [4301], 'effect),': [4302], 'lower': [4305], 'ATP': [4306], 'lactic': [4309], 'production,': [4311], 'acidosis': [4314], '(34Seagroves': [4315], 'T.N.': [4316], 'Ryan': [4317], 'H.E.,': [4318], 'Lu,': [4319], 'Wouters': [4321], 'B.G.': [4322], 'Knapp': [4323], 'Thibault': [4325], 'Laderoute': [4327], 'Mol.': [4331, 5496], '21:': [4335], '3436-3444Crossref': [4336], '(476)': [4339], 'completely': [4354], 'suppressed': [4355, 4649], 'indicating': [4359], 'requirement': [4362, 4759], 'Under': [4368], 'pHIF-1α': [4371, 4459], 'ubiquitinated': [4373], 'system': [4380], 'mechanism': [4451], 'regulates': [4455, 5117], 'half-life': [4457], 'involves': [4460], 'Pro564': [4464], '(and': [4465], 'residues)': [4468], 'hydroxylation,': [4541], 'interacts': [4543], 'ligase,': [4551], 'targeting': [4553], 'examined': [4558], 'enzymes.': [4581], 'result': [4592], 'inability': [4595], 'degrade': [4597], 'VEGF,': [4639], 'mRNAs': [4642], 'partially,': [4646], 'significantly,': [4648], 'HIF-prolyl': [4658, 4813], 'hydroxylases': [4659, 4814], 'group': [4662], 'post-translationally': [4668], 'modify': [4669], 'concentration-dependent': [4674], 'manner': [4675], 'structural': [4744], 'catalytic': [4747], 'mechanisms': [4748], 'members': [4750], 'oxygenases': [4752], 'type': [4755], 'co-workers': [4769], 'showed': [4806], 'inhibited': [4817, 5131], '2-oxoglutarate': [4819], 'analogs.': [4820], 'N-oxalylglycine': [4826], 'discussed': [4840], 'above': [4841], 'suggest': [4842], 'HIF': [4845], 'structure': [4855], 'spans': [4865], 'more': [4866], 'than': [4867], '26': [4868], 'kb': [4869], 'least': [4872], 'exons': [4874], '(36Navarro-Sabate': [4875], 'Manzano': [4877, 5002], 'Riera': [4879, 5004], 'Gene.': [4887, 5012], '264:': [4889, 5014], '131-138Crossref': [4890, 5015], '(30)': [4893, 5018], 'accounts': [4897], 'ubiquituous': [4901], 'generated': [4905], 'alternative': [4907], 'splicing': [4908], 'exon': [4910], '15.': [4911], 'probe,': [4913], 'included': [4915], 'nucleotides': [4918], '901–1218,': [4919], 'differentiate': [4922], 'between': [4923], 'Computer': [4927], 'data': [4928], 'base': [4929], 'promoter': [4933], 'revealed': [4939], 'TATA': [4941], 'box': [4942], 'potential': [4944], 'binding': [4945, 4968, 5078], 'sites': [4946], 'factors.': [4950], 'Several': [4951], 'G': [4952], '+': [4953], 'C-rich': [4954], 'regions': [4955], 'proximal': [4959], '5′-end': [4960], 'consistent': [4962], 'putative': [4964], 'motifs': [4965], 'Sp1': [4970], 'AP-2': [4972], 'factors': [4973], '(35Fukasawa': [4974], 'Takayama': [4976], 'Shinoniya': [4978], 'Okumura': [4980], 'Rocutanda': [4982], 'Yamamoto': [4984], '267:': [4993], '703-708Crossref': [4994], '(8)': [4997], '36Navarro-Sabate': [5000], 'Potential': [5021], '(5′-RCGTG-3′)': [5024], 'positions': [5029], '5′': [5032], 'flanking': [5033], 'them,': [5040], 'position': [5042], '−103': [5043], '−108': [5045], 'start': [5049], 'site,': [5050], 'conforms': [5051], '(18Semenza': [5065], 'exact': [5076], 'site': [5079], 'involved': [5080], 'regulation': [5084], 'yet': [5092], 'determined.': [5093], 'addition,': [5095], 'possible': [5097], 'stability': [5103], 'studied.': [5110], 'Phosphofructuokinase': [5111], 'ADP': [5127], 'AMP': [5129], 'ATP.': [5133], 'believed': [5136], 'F-(2,6)-P2': [5138, 5151], 'enzyme.': [5146], 'balance': [5156], 'activities': [5162, 5430], 'PFK-2/F-2,6-BPase,': [5164], 'vary': [5166], 'types': [5170], 'modulated': [5173], 'various': [5175], '(3Okar': [5178], 'demonstration': [5192], 'increases': [5195], 'compatible': [5203], 'enhances': [5209], 'periods': [5212], 'deficiency.': [5215], 'Tumor': [5216], 'expansion': [5219], 'ability': [5223], 'new': [5226], 'blood': [5227], 'vessels': [5228], '(angiogenesis)': [5229], 'capacity': [5232], 'adapt': [5234], 'metabolism': [5236], 'own': [5244], 'growth.': [5245], 'critical': [5254], 'enhanced': [5263], 'variety': [5267], 'nutrient': [5274], 'supply': [5275], '(17Wenger': [5276], 'adaptations,': [5304], 'here,': [5307], 'likely': [5309], 'include': [5311], 'pathway.': [5318], 'should': [5320], 'noted': [5322], 'condition': [5329], 'stabilizes': [5331], 'Certain': [5335], 'hormones': [5336], 'insulin,': [5341], 'angiotensin': [5342], 'II,': [5343], 'platelet-derived': [5345], 'factor,': [5347], 'cytokines': [5349], 'interleukin-1': [5352], 'necrosis': [5355], 'lead': [5359], 'stabilization': [5362], '(37Richard': [5363], 'D.E.': [5364], 'Berra': [5365], 'Pouysségur': [5367], '26765-26771Abstract': [5374], '38Thornton': [5383], 'Borghaei': [5387], 'Paese': [5389], 'Mochan': [5393], '350:': [5398], '307-312Crossref': [5399], '(189)': [5402], 'tumors,': [5406], 'often': [5409, 5530], 'constitutively,': [5411], 'case': [5419], 'mutations,': [5422], 'consequence': [5426], 'oncogenic': [5429], '(39Talks': [5431], 'K.L.': [5432], 'Turley': [5433], 'Gatter': [5435], 'K.C.': [5436], 'Pathol.': [5447], '157:': [5449], '411-421Abstract': [5450], '(1088)': [5458], '40Zagzag': [5461], 'Zhong': [5463], 'Scalzitti': [5465], 'Laughner': [5467], 'Simons': [5469], 'J.W.': [5470], 'Cancer.': [5473], '88:': [5475], '2606-2618Crossref': [5476], '(555)': [5479], '41Hoffman': [5482], 'Klco': [5488], 'Ivan': [5490], 'Hum.': [5495], '1019-1027Crossref': [5500], '(321)': [5503], 'tempting': [5508], 'speculate': [5510], 'those': [5513], 'cases': [5514], 'over-expressed,': [5518], 'providing': [5520], 'effect,': [5526], 'so': [5529], '(43Warburg': [5535], '1956;': [5538], '123:': [5539], '309-314Crossref': [5540], '(9416)': [5543], 'thank': [5547], 'investigators': [5549], 'who': [5550], 'reagents': [5555], 'work:': [5559], 'Dr.': [5560], 'Oxford,': [5565], 'England)': [5566], 'dimethyloxalylglycine;': [5569], 'Diego)': [5577], 'fibroblasts;': [5582], 'Squibb)': [5586], 'appreciate': [5593], 'help': [5595], 'Likens': [5598], 'artwork': [5600], 'Silvano': [5603], 'secretarial': [5605], 'assistance.': [5606]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2127255821', 'counts_by_year': [{'year': 2024, 'cited_by_count': 14}, {'year': 2023, 'cited_by_count': 16}, {'year': 2022, 'cited_by_count': 14}, {'year': 2021, 'cited_by_count': 22}, {'year': 2020, 'cited_by_count': 24}, {'year': 2019, 'cited_by_count': 11}, {'year': 2018, 'cited_by_count': 10}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 17}, {'year': 2014, 'cited_by_count': 14}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 19}], 'updated_date': '2024-12-12T17:11:15.953948', 'created_date': '2016-06-24'}
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