Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2127075994', 'doi': 'https://doi.org/10.1095/biolreprod.111.094714', 'title': 'Simvastatin Reduces Steroidogenesis by Inhibiting Cyp17a1 Gene Expression in Rat Ovarian Theca-Interstitial Cells1', 'display_name': 'Simvastatin Reduces Steroidogenesis by Inhibiting Cyp17a1 Gene Expression in Rat Ovarian Theca-Interstitial Cells1', 'publication_year': 2011, 'publication_date': '2011-09-15', 'ids': {'openalex': 'https://openalex.org/W2127075994', 'doi': 'https://doi.org/10.1095/biolreprod.111.094714', 'mag': '2127075994', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21918126', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3313666'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1095/biolreprod.111.094714', 'pdf_url': 'https://academic.oup.com/biolreprod/article-pdf/86/1/20, 1-9/10578810/biolreprod0020.pdf', 'source': {'id': 'https://openalex.org/S130598054', 'display_name': 'Biology of Reproduction', 'issn_l': '0006-3363', 'issn': ['0006-3363', '1529-7268'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/biolreprod/article-pdf/86/1/20, 1-9/10578810/biolreprod0020.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5103529696', 'display_name': 'Israel Ortega', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210141790', 'display_name': 'IVI Madrid Clinic', 'ror': 'https://ror.org/04606tc02', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210141790']}, {'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['ES', 'US'], 'is_corresponding': False, 'raw_author_name': 'Israel Ortega', 'raw_affiliation_strings': ['Department of Obstetrics and Gynecology, School of Medicine, University of California-Davis, Sacramento, California', 'IVI-Madrid, Madrid, Spain'], 'affiliations': [{'raw_affiliation_string': 'IVI-Madrid, Madrid, Spain', 'institution_ids': ['https://openalex.org/I4210141790']}, {'raw_affiliation_string': 'Department of Obstetrics and Gynecology, School of Medicine, University of California-Davis, Sacramento, California', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077479797', 'display_name': 'Amanda B. Cress', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Amanda B. Cress', 'raw_affiliation_strings': ['Department of Obstetrics and Gynecology, School of Medicine, University of California-Davis, Sacramento, California'], 'affiliations': [{'raw_affiliation_string': 'Department of Obstetrics and Gynecology, School of Medicine, University of California-Davis, Sacramento, California', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109127033', 'display_name': 'Donna H. Wong', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Donna H. Wong', 'raw_affiliation_strings': ['Department of Obstetrics and Gynecology, School of Medicine, University of California-Davis, Sacramento, California'], 'affiliations': [{'raw_affiliation_string': 'Department of Obstetrics and Gynecology, School of Medicine, University of California-Davis, Sacramento, California', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056107787', 'display_name': 'Jesus A. Villanueva', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jesus A. Villanueva', 'raw_affiliation_strings': ['Department of Obstetrics and Gynecology, School of Medicine, University of California-Davis, Sacramento, California'], 'affiliations': [{'raw_affiliation_string': 'Department of Obstetrics and Gynecology, School of Medicine, University of California-Davis, Sacramento, California', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086799519', 'display_name': 'Anna Sokalska', 'orcid': 'https://orcid.org/0000-0003-3000-3811'}, 'institutions': [{'id': 'https://openalex.org/I120230055', 'display_name': 'Poznan University of Medical Sciences', 'ror': 'https://ror.org/02zbb2597', 'country_code': 'PL', 'type': 'education', 'lineage': ['https://openalex.org/I120230055']}, {'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['PL', 'US'], 'is_corresponding': False, 'raw_author_name': 'Anna Sokalska', 'raw_affiliation_strings': ['Department of Gynecology, Obstetrics and Gynecological Oncology, Karol Marcinkowski University of Medical Sciences, Poznan, Poland', 'Department of Obstetrics and Gynecology, School of Medicine, University of California-Davis, Sacramento, California'], 'affiliations': [{'raw_affiliation_string': 'Department of Gynecology, Obstetrics and Gynecological Oncology, Karol Marcinkowski University of Medical Sciences, Poznan, Poland', 'institution_ids': ['https://openalex.org/I120230055']}, {'raw_affiliation_string': 'Department of Obstetrics and Gynecology, School of Medicine, University of California-Davis, Sacramento, California', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062257792', 'display_name': 'Ben C. Moeller', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ben C. Moeller', 'raw_affiliation_strings': ['Department of Molecular Biosciences, University of California-Davis, Davis, California'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Biosciences, University of California-Davis, Davis, California', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103495252', 'display_name': 'Scott D. Stanley', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Scott D. Stanley', 'raw_affiliation_strings': ['Department of Molecular Biosciences, University of California-Davis, Davis, California'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Biosciences, University of California-Davis, Davis, California', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5012214295', 'display_name': 'Antoni J. Dulęba', 'orcid': 'https://orcid.org/0000-0003-1419-6502'}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Antoni J. Duleba', 'raw_affiliation_strings': ['Department of Obstetrics and Gynecology, School of Medicine, University of California-Davis, Sacramento, California'], 'affiliations': [{'raw_affiliation_string': 'Department of Obstetrics and Gynecology, School of Medicine, University of California-Davis, Sacramento, California', 'institution_ids': ['https://openalex.org/I84218800']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5012214295'], 'corresponding_institution_ids': ['https://openalex.org/I84218800'], 'apc_list': {'value': 4217, 'currency': 'USD', 'value_usd': 4217, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 17.039, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 155, 'citation_normalized_percentile': {'value': 0.999823, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '86', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10390', 'display_name': 'Ovarian function and disorders', 'score': 0.992, 'subfield': {'id': 'https://openalex.org/subfields/2743', 'display_name': 'Reproductive Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10390', 'display_name': 'Ovarian function and disorders', 'score': 0.992, 'subfield': {'id': 'https://openalex.org/subfields/2743', 'display_name': 'Reproductive Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11146', 'display_name': 'Hormonal and reproductive studies', 'score': 0.9905, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10748', 'display_name': 'Growth Hormone and Insulin-like Growth Factors', 'score': 0.9887, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/geranylgeranyl-pyrophosphate', 'display_name': 'Geranylgeranyl pyrophosphate', 'score': 0.66837186}, {'id': 'https://openalex.org/keywords/cyp17a1', 'display_name': 'CYP17A1', 'score': 0.62979347}, {'id': 'https://openalex.org/keywords/farnesyl-pyrophosphate', 'display_name': 'Farnesyl pyrophosphate', 'score': 0.58164424}, {'id': 'https://openalex.org/keywords/geranylgeraniol', 'display_name': 'Geranylgeraniol', 'score': 0.54164016}], 'concepts': [{'id': 'https://openalex.org/C175805485', 'wikidata': 'https://www.wikidata.org/wiki/Q2367166', 'display_name': 'Theca', 'level': 3, 'score': 0.7818278}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.7533212}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.73811305}, {'id': 'https://openalex.org/C2778827360', 'wikidata': 'https://www.wikidata.org/wiki/Q774795', 'display_name': 'Geranylgeranyl pyrophosphate', 'level': 4, 'score': 0.66837186}, {'id': 'https://openalex.org/C142716871', 'wikidata': 'https://www.wikidata.org/wiki/Q408305', 'display_name': 'CYP17A1', 'level': 3, 'score': 0.62979347}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.60375595}, {'id': 'https://openalex.org/C2776990775', 'wikidata': 'https://www.wikidata.org/wiki/Q2699676', 'display_name': 'Farnesyl pyrophosphate', 'level': 4, 'score': 0.58164424}, {'id': 'https://openalex.org/C2777911890', 'wikidata': 'https://www.wikidata.org/wiki/Q62614', 'display_name': 'Androgen', 'level': 3, 'score': 0.57863003}, {'id': 'https://openalex.org/C57790582', 'wikidata': 'https://www.wikidata.org/wiki/Q901141', 'display_name': 'Prenylation', 'level': 3, 'score': 0.545608}, {'id': 'https://openalex.org/C2778359262', 'wikidata': 'https://www.wikidata.org/wiki/Q3123708', 'display_name': 'Geranylgeraniol', 'level': 3, 'score': 0.54164016}, {'id': 'https://openalex.org/C2776839432', 'wikidata': 'https://www.wikidata.org/wiki/Q954845', 'display_name': 'Statin', 'level': 2, 'score': 0.53995585}, {'id': 'https://openalex.org/C2776329913', 'wikidata': 'https://www.wikidata.org/wiki/Q670131', 'display_name': 'Simvastatin', 'level': 2, 'score': 0.44985828}, {'id': 'https://openalex.org/C2778324911', 'wikidata': 'https://www.wikidata.org/wiki/Q9631', 'display_name': 'Ovary', 'level': 2, 'score': 0.21876585}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.14833912}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.11596906}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.1133163}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C553450214', 'wikidata': 'https://www.wikidata.org/wiki/Q851162', 'display_name': 'Biosynthesis', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D015971', 'descriptor_name': 'Gene Expression Regulation, Enzymologic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D010053', 'descriptor_name': 'Ovary', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D019821', 'descriptor_name': 'Simvastatin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D013254', 'descriptor_name': 'Steroid 17-alpha-Hydroxylase', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D013254', 'descriptor_name': 'Steroid 17-alpha-Hydroxylase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019883', 'descriptor_name': 'Alkyl and Aryl Transferases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D019883', 'descriptor_name': 'Alkyl and Aryl Transferases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051231', 'descriptor_name': 'Farnesyltranstransferase', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D051231', 'descriptor_name': 'Farnesyltranstransferase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015971', 'descriptor_name': 'Gene Expression Regulation, Enzymologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006888', 'descriptor_name': 'Hydroxycholesterols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019161', 'descriptor_name': 'Hydroxymethylglutaryl-CoA Reductase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019161', 'descriptor_name': 'Hydroxymethylglutaryl-CoA Reductase Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010053', 'descriptor_name': 'Ovary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011106', 'descriptor_name': 'Polyisoprenyl Phosphates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011106', 'descriptor_name': 'Polyisoprenyl Phosphates', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D060888', 'descriptor_name': 'Real-Time Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012717', 'descriptor_name': 'Sesquiterpenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012717', 'descriptor_name': 'Sesquiterpenes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019821', 'descriptor_name': 'Simvastatin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013254', 'descriptor_name': 'Steroid 17-alpha-Hydroxylase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D013254', 'descriptor_name': 'Steroid 17-alpha-Hydroxylase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013379', 'descriptor_name': 'Substrate Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1095/biolreprod.111.094714', 'pdf_url': 'https://academic.oup.com/biolreprod/article-pdf/86/1/20, 1-9/10578810/biolreprod0020.pdf', 'source': {'id': 'https://openalex.org/S130598054', 'display_name': 'Biology of Reproduction', 'issn_l': '0006-3363', 'issn': ['0006-3363', '1529-7268'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3313666', 'pdf_url': 'https://europepmc.org/articles/pmc3313666?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3313666', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21918126', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1095/biolreprod.111.094714', 'pdf_url': 'https://academic.oup.com/biolreprod/article-pdf/86/1/20, 1-9/10578810/biolreprod0020.pdf', 'source': {'id': 'https://openalex.org/S130598054', 'display_name': 'Biology of Reproduction', 'issn_l': '0006-3363', 'issn': ['0006-3363', '1529-7268'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.75}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 32, 'referenced_works': ['https://openalex.org/W1563945962', 'https://openalex.org/W1783146542', 'https://openalex.org/W1965489478', 'https://openalex.org/W1967738319', 'https://openalex.org/W1991710808', 'https://openalex.org/W1995813378', 'https://openalex.org/W1999595275', 'https://openalex.org/W2013394985', 'https://openalex.org/W2018270574', 'https://openalex.org/W2033249094', 'https://openalex.org/W2033857270', 'https://openalex.org/W2034063903', 'https://openalex.org/W2036649716', 'https://openalex.org/W2040710110', 'https://openalex.org/W2060496328', 'https://openalex.org/W2066712230', 'https://openalex.org/W2070126347', 'https://openalex.org/W2083409267', 'https://openalex.org/W2113585098', 'https://openalex.org/W2116696220', 'https://openalex.org/W2124724942', 'https://openalex.org/W2132519336', 'https://openalex.org/W2134223591', 'https://openalex.org/W2145679804', 'https://openalex.org/W2152056874', 'https://openalex.org/W2152740187', 'https://openalex.org/W2155440953', 'https://openalex.org/W2156682105', 'https://openalex.org/W2163762391', 'https://openalex.org/W2170033994', 'https://openalex.org/W2176744910', 'https://openalex.org/W2405127220'], 'related_works': ['https://openalex.org/W3157133258', 'https://openalex.org/W3156774255', 'https://openalex.org/W2170899746', 'https://openalex.org/W2162998993', 'https://openalex.org/W2127075994', 'https://openalex.org/W2061958421', 'https://openalex.org/W2061595030', 'https://openalex.org/W2020690650', 'https://openalex.org/W1975107690', 'https://openalex.org/W1490080803'], 'abstract_inverted_index': {'Polycysticovary': [0], 'syndrome': [1], '(PCOS)': [2], 'is': [3, 204], 'characterized': [4], 'by': [5, 14, 91, 189], 'ovarian': [6, 63], 'enlargement,': [7], 'theca-interstitial': [8, 40, 64], 'hyperplasia,': [9], 'and': [10, 44, 93, 100, 111, 121, 141, 170, 192], 'increased': [11], 'androgen': [12, 47, 136, 163, 202], 'production': [13], 'theca': [15], 'cells.': [16], 'Previously,': [17], 'our': [18], 'group': [19], 'has': [20], 'demonstrated': [21], 'that': [22, 198], 'statins': [23, 70], '(competitive': [24], 'inhibitors': [25, 107], 'of': [26, 33, 39, 59, 69, 80, 108, 154, 184, 201, 214, 220], '3-hydroxy-3-methyl-glutaryl-coenzyme': [27], 'A': [28], 'reductase,': [29], 'a': [30, 139, 149], 'rate-limiting': [31], 'step': [32], 'the': [34, 57, 82, 156, 159, 181, 212], 'mevalonate': [35], 'pathway)': [36], 'reduce': [37], 'proliferation': [38], 'cells': [41, 115], 'in': [42, 49, 138, 151, 209, 217], 'vitro': [43], 'decrease': [45, 150], 'serum': [46], 'levels': [48, 137, 153, 203], 'women': [50], 'with': [51, 124, 148], 'PCOS.': [52], 'The': [53, 194], 'present': [54, 83, 195], 'study': [55, 84], 'evaluated': [56], 'effect': [58, 146, 175], 'simvastatin': [60, 185], 'on': [61, 176], 'rat': [62], 'cell': [65], 'steroidogenesis.': [66], 'Because': [67], 'actions': [68], 'may': [71], 'be': [72], 'due': [73], 'to': [74, 211], 'reduced': [75], 'cholesterol': [76], 'availability': [77], 'and/or': [78, 132], 'isoprenylation': [79, 96], 'proteins,': [81], 'also': [85], 'investigated': [86], 'whether': [87], 'steroidogenesis': [88], 'was': [89, 186], 'affected': [90], 'cell-': [92], 'mitochondrion-permeable': [94], '22-hydroxycholesterol,': [95], 'substrates': [97], '(farnesyl-pyrophosphate': [98], '[FPP]': [99], 'geranylgeranyl-pyrophosphate': [101], '[GGPP]),': [102], 'as': [103, 105], 'well': [104], 'selective': [106], 'farnesyltransferase': [109], '(FTI)': [110], 'geranylgeranyltransferase': [112], '(GGTI).': [113], 'Theca-interstitial': [114], 'were': [116], 'cultured': [117], 'for': [118], '12,': [119], '24,': [120], '48': [122, 166], 'h': [123], 'or': [125], 'without': [126], 'simvastatin,': [127], 'GGPP,': [128], 'FPP,': [129], 'FTI,': [130], 'GGTI,': [131], '22-hydroxycholesterol.': [133], 'Simvastatin': [134], 'decreased': [135, 218], 'time-': [140], 'concentration-dependent': [142], 'fashion.': [143], 'This': [144], 'inhibitory': [145, 182], 'correlated': [147], 'mRNA': [152, 178], 'Cyp17a1,': [155], 'gene': [157], 'encoding': [158], 'key': [160], 'enzyme': [161], 'regulating': [162], 'biosynthesis.': [164], 'After': [165], 'h,': [167], 'GGPP': [168, 191], 'alone': [169, 172], 'FPP': [171], 'had': [173], 'no': [174], 'Cyp17a1': [177], 'expression;': [179], 'however,': [180], 'action': [183], 'partly': [187], 'abrogated': [188], 'both': [190], 'FPP.': [193], 'findings': [196], 'indicate': [197], 'statin-induced': [199], 'reduction': [200], 'likely': [205], 'due,': [206], 'at': [207], 'least': [208], 'part,': [210], 'inhibition': [213], 'isoprenylation,': [215], 'resulting': [216], 'expression': [219], 'CYP17A1.': [221]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2127075994', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 16}, {'year': 2017, 'cited_by_count': 14}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 14}, {'year': 2014, 'cited_by_count': 23}, {'year': 2013, 'cited_by_count': 25}, {'year': 2012, 'cited_by_count': 14}], 'updated_date': '2024-12-10T11:35:25.679837', 'created_date': '2016-06-24'}