Title: Continuous‐Flow Synthesis of 3,3‐Disubstituted Oxindoles by a Palladium‐Catalyzed α‐Arylation/Alkylation Sequence
Abstract: Angewandte Chemie International EditionVolume 50, Issue 28 p. 6396-6400 Communication Continuous-Flow Synthesis of 3,3-Disubstituted Oxindoles by a Palladium-Catalyzed α-Arylation/Alkylation Sequence† Dr. Pengfei Li, Dr. Pengfei Li Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139 (USA), Fax: (+1) 617-253-3297Search for more papers by this authorProf. Stephen L. Buchwald, Corresponding Author Prof. Stephen L. Buchwald [email protected] Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139 (USA), Fax: (+1) 617-253-3297Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139 (USA), Fax: (+1) 617-253-3297Search for more papers by this author Dr. Pengfei Li, Dr. Pengfei Li Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139 (USA), Fax: (+1) 617-253-3297Search for more papers by this authorProf. Stephen L. Buchwald, Corresponding Author Prof. Stephen L. Buchwald [email protected] Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139 (USA), Fax: (+1) 617-253-3297Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139 (USA), Fax: (+1) 617-253-3297Search for more papers by this author First published: 07 June 2011 https://doi.org/10.1002/anie.201102401Citations: 82 † We thank Novartis International AG for funding. The 300 MHz NMR instrument used was supported by the National Science Foundation (Grants CHE-9808061 and DBI-9729592) Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract Facilitating chemistry: Key to the success of Pd-catalyzed α-arylation of oxindoles in continuous flow involved a biphasic system, a precatalyst, and a packed-bed microreactor. Furthermore, this reaction was integrated into a two-step continuous-flow sequence for rapid, modular, and efficient syntheses of 3,3-disubstituted oxindoles. Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description anie_201102401_sm_miscellaneous_information.pdf10.3 MB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. 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