Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2126945620', 'doi': 'https://doi.org/10.7326/0003-4819-143-5-200509060-00021', 'title': 'Minocycline for the Treatment of Takayasu Arteritis', 'display_name': 'Minocycline for the Treatment of Takayasu Arteritis', 'publication_year': 2005, 'publication_date': '2005-09-06', 'ids': {'openalex': 'https://openalex.org/W2126945620', 'doi': 'https://doi.org/10.7326/0003-4819-143-5-200509060-00021', 'mag': '2126945620', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16144901'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.7326/0003-4819-143-5-200509060-00021', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S119722071', 'display_name': 'Annals of Internal Medicine', 'issn_l': '0003-4819', 'issn': ['0003-4819', '1539-3704'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316812', 'host_organization_name': 'American College of Physicians', 'host_organization_lineage': ['https://openalex.org/P4310316812'], 'host_organization_lineage_names': ['American College of Physicians'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'letter', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5033747502', 'display_name': 'Akifumi Matsuyama', 'orcid': 'https://orcid.org/0000-0001-7011-0326'}, 'institutions': [{'id': 'https://openalex.org/I98285908', 'display_name': 'Osaka University', 'ror': 'https://ror.org/035t8zc32', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I98285908']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Akifumi Matsuyama', 'raw_affiliation_strings': ['From Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.'], 'affiliations': [{'raw_affiliation_string': 'From Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.', 'institution_ids': ['https://openalex.org/I98285908']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017645796', 'display_name': 'Naohiko Sakai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98285908', 'display_name': 'Osaka University', 'ror': 'https://ror.org/035t8zc32', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I98285908']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Naohiko Sakai', 'raw_affiliation_strings': ['From Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.'], 'affiliations': [{'raw_affiliation_string': 'From Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.', 'institution_ids': ['https://openalex.org/I98285908']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067820808', 'display_name': 'Masato Ishigami', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98285908', 'display_name': 'Osaka University', 'ror': 'https://ror.org/035t8zc32', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I98285908']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masato Ishigami', 'raw_affiliation_strings': ['From Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.'], 'affiliations': [{'raw_affiliation_string': 'From Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.', 'institution_ids': ['https://openalex.org/I98285908']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032545147', 'display_name': 'Hisatoyo Hiraoka', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98285908', 'display_name': 'Osaka University', 'ror': 'https://ror.org/035t8zc32', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I98285908']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hisatoyo Hiraoka', 'raw_affiliation_strings': ['From Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.'], 'affiliations': [{'raw_affiliation_string': 'From Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.', 'institution_ids': ['https://openalex.org/I98285908']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103268361', 'display_name': 'Shizuya Yamashita', 'orcid': 'https://orcid.org/0000-0002-8413-5468'}, 'institutions': [{'id': 'https://openalex.org/I98285908', 'display_name': 'Osaka University', 'ror': 'https://ror.org/035t8zc32', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I98285908']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shizuya Yamashita', 'raw_affiliation_strings': ['From Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.'], 'affiliations': [{'raw_affiliation_string': 'From Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.', 'institution_ids': ['https://openalex.org/I98285908']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': False, 'cited_by_count': 26, 'citation_normalized_percentile': {'value': 0.909804, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 88, 'max': 89}, 'biblio': {'volume': '143', 'issue': '5', 'first_page': '394', 'last_page': '394'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10697', 'display_name': 'Classification and Management of Vasculitides', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10697', 'display_name': 'Classification and Management of Vasculitides', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11917', 'display_name': 'Hereditary Angioedema: Molecular Mechanisms and Clinical Management', 'score': 0.9908, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12955', 'display_name': 'Immunological Mechanisms in Atherosclerosis Development', 'score': 0.974, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/takayasu-arteritis', 'display_name': 'Takayasu Arteritis', 'score': 0.621024}, {'id': 'https://openalex.org/keywords/arteritis', 'display_name': 'Arteritis', 'score': 0.5832077}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.66419476}, {'id': 'https://openalex.org/C2781343717', 'wikidata': 'https://www.wikidata.org/wiki/Q1751810', 'display_name': 'Arteritis', 'level': 2, 'score': 0.5832077}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.45689297}], 'mesh': [{'descriptor_ui': 'D000893', 'descriptor_name': 'Anti-Inflammatory Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D008911', 'descriptor_name': 'Minocycline', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D011239', 'descriptor_name': 'Prednisolone', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D013625', 'descriptor_name': 'Takayasu Arteritis', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000893', 'descriptor_name': 'Anti-Inflammatory Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004359', 'descriptor_name': 'Drug Therapy, Combination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008911', 'descriptor_name': 'Minocycline', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011239', 'descriptor_name': 'Prednisolone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013625', 'descriptor_name': 'Takayasu Arteritis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.7326/0003-4819-143-5-200509060-00021', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S119722071', 'display_name': 'Annals of Internal Medicine', 'issn_l': '0003-4819', 'issn': ['0003-4819', '1539-3704'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316812', 'host_organization_name': 'American College of Physicians', 'host_organization_lineage': ['https://openalex.org/P4310316812'], 'host_organization_lineage_names': ['American College of Physicians'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16144901', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.51}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 3, 'referenced_works': ['https://openalex.org/W1234369612', 'https://openalex.org/W1981729580', 'https://openalex.org/W2163547851'], 'related_works': ['https://openalex.org/W4389568370', 'https://openalex.org/W3108674512', 'https://openalex.org/W3032375762', 'https://openalex.org/W3031052312', 'https://openalex.org/W2748952813', 'https://openalex.org/W2148612803', 'https://openalex.org/W2080531066', 'https://openalex.org/W1995515455', 'https://openalex.org/W1506200166', 'https://openalex.org/W1489783725'], 'abstract_inverted_index': {'Letters6': [0], 'September': [1, 519, 530, 535], '2005Minocycline': [2], 'for': [3, 41, 60, 79, 98, 118, 229, 255, 470], 'the': [4, 176, 194, 220, 256, 328], 'Treatment': [5], 'of': [6, 36, 55, 74, 93, 113, 144, 180, 187, 193, 214, 222, 251, 258, 330, 357, 395, 445, 463, 479, 500, 545], 'Takayasu': [7, 139, 181, 231, 259, 282, 313, 471, 514], 'ArteritisAkifumi': [8], 'Matsuyama,': [9, 29, 371], 'MD,': [10, 14, 18, 22, 27, 30, 49, 68, 87, 107, 372, 376, 380, 384, 388], 'PhD,': [11, 15, 19, 23], 'Naohiko': [12, 47, 374], 'Sakai,': [13, 48, 375], 'Masato': [16, 66, 378], 'Ishigami,': [17, 67, 379], 'Hisatoyo': [20, 85, 382], 'Hiraoka,': [21, 86, 383], 'and': [24, 104, 125, 178, 183, 227, 367, 429, 443, 460, 482, 492, 498, 513], 'Shizuya': [25, 105, 386], 'Yamashita,': [26, 106, 387], 'PhDAkifumi': [28], 'PhDFrom': [31, 50, 69, 88, 108], 'Osaka': [32, 38, 51, 57, 70, 76, 89, 95, 109, 115, 391, 397], 'University': [33, 52, 71, 90, 110, 392], 'Graduate': [34, 53, 72, 91, 111, 393], 'School': [35, 54, 73, 92, 112, 394], 'Medicine,': [37, 56, 75, 94, 114, 396], '565-0871,': [39, 58, 77, 96, 116, 398], 'Japan.Search': [40, 59, 78, 97, 117], 'more': [42, 61, 80, 99, 119], 'papers': [43, 62, 81, 100, 120], 'by': [44, 63, 82, 101, 121, 542], 'this': [45, 64, 83, 102, 122], 'author,': [46, 65, 84, 103], 'authorAuthor,': [123], 'Article,': [124, 366], 'Disclosure': [126, 368], 'Informationhttps://doi.org/10.7326/0003-4819-143-5-200509060-00021': [127], 'SectionsAboutFull': [128], 'TextPDF': [129], 'ToolsAdd': [130], 'to': [131, 155, 175], 'favoritesDownload': [132], 'CitationsTrack': [133], 'CitationsPermissions': [134], 'ShareFacebookTwitterLinkedInRedditEmail': [135], 'TO': [136], 'THE': [137], 'EDITOR:Background:': [138], 'arteritis': [140, 182, 436], 'is': [141, 212], 'a': [142, 438, 488, 509], 'type': [143], 'chronic': [145], 'vasculitis': [146], 'that': [147, 169, 184, 211], 'primarily': [148], 'affects': [149], 'large': [150], 'elastic': [151], 'arteries.': [152], 'It': [153], 'tends': [154], 'progress': [156], 'despite': [157], 'treatment': [158, 224], 'with': [159, 225, 441], 'glucocorticoids': [160], 'or': [161], 'immunosuppressive': [162], 'agents': [163], '(1,': [164], '2).': [165], 'Recently,': [166], 'we': [167], 'reported': [168], 'matrix': [170, 331], 'metalloproteinases': [171, 307], '(MMPs)': [172], 'might': [173], 'contribute': [174], 'pathogenesis': [177], 'exacerbation': [179], 'circulating': [185], 'levels': [186], 'MMPs': [188], 'could': [189], 'be': [190], 'diagnostic': [191], 'markers': [192, 311], 'disease': [195, 310], '(3).': [196], 'While': [197], 'many': [198], 'MMP': [199, 208], 'inhibitors': [200], 'are': [201], 'under': [202], 'development': [203], '(4),': [204], 'minocycline': [205, 226], 'has': [206], 'established': [207], 'inhibitor': [209], 'activity': [210, 216], 'independent': [213], 'antimicrobial': [215], '(5).Objective:': [217], 'To': [218], 'assess': [219], 'effect': [221], 'combination': [223], 'glucocorticoid': [228], 'active': [230], 'arteritis.Methods': [232], '...References1.': [233], 'Arend': [234], 'WP,': [235], 'Michel': [236], 'BA,': [237], 'Bloch': [238], 'DA,': [239], 'Hunder': [240], 'GG,': [241], 'Calabrese': [242], 'LH,': [243], 'Edworthy': [244], 'SM,': [245], 'et': [246, 280, 304], 'al.': [247, 281, 305], 'The': [248], 'American': [249, 543], 'College': [250, 544], 'Rheumatology': [252], '1990': [253], 'criteria': [254], 'classification': [257], 'arteritis.': [260, 283, 314], 'Arthritis': [261], 'Rheum.': [262], '1990;33:1129-34.': [263], '[PMID:': [264, 288, 317, 340], '1975175]': [265], 'CrossrefMedlineGoogle': [266, 319], 'Scholar2.': [267], 'Kerr': [268, 409], 'GS,': [269], 'Hallahan': [270, 413], 'CW,': [271], 'Giordano': [272, 416], 'J,': [273], 'Leavitt': [274, 420], 'RY,': [275], 'Fauci': [276, 424], 'AS,': [277], 'Rottem': [278, 427], 'M,': [279, 297], 'Ann': [284], 'Intern': [285], 'Med.': [286], '1994;120:919-29.': [287], '7909656]': [289], 'LinkGoogle': [290], 'Scholar3.': [291], 'Matsuyama': [292], 'A,': [293, 303], 'Sakai': [294], 'N,': [295], 'Ishigami': [296], 'Hiraoka': [298], 'H,': [299, 322], 'Kashine': [300], 'S,': [301, 349], 'Hirata': [302], 'Matrix': [306, 464, 473, 480], 'as': [308], 'novel': [309], 'in': [312, 327, 437, 455, 466, 475, 487, 496], 'Circulation.': [315], '2003;108:1469-73.': [316], '12952836]': [318], 'Scholar4.': [320], 'Matter': [321], 'Schudok': [323], 'M.': [324], 'Recent': [325], 'advances': [326], 'design': [329], 'metalloprotease': [332], 'inhibitors.': [333], 'Curr': [334], 'Opin': [335], 'Drug': [336], 'Discov': [337], 'Devel.': [338], '2004;7:513-35.': [339], '15338961]': [341], 'MedlineGoogle': [342], 'Scholar5.': [343], 'Cooper': [344], 'SM.': [345], 'Tetracyclines..': [346], 'In:': [347], 'Ruddy': [348], 'Harris': [350], 'ED,': [351], 'Sledge': [352], 'CB,': [353], 'eds.': [354], "Kelley's": [355], 'Textbook': [356], 'Rheumatology.': [358], 'Philadelphia:': [359], 'WB': [360], 'Saunders;': [361], '2001:913-20.': [362], 'Google': [363], 'Scholar': [364], 'Author,': [365], 'InformationAuthors:': [369], 'Akifumi': [370], 'PhD;': [373, 377, 381, 385], 'PhDAffiliations:': [389], 'From': [390], 'Japan.Disclosures:': [399], 'None': [400], 'disclosed.': [401], 'PreviousarticleNextarticle': [402], 'Advertisement': [403], 'FiguresReferencesRelatedDetailsSee': [404], 'AlsoTakayasu': [405], 'Arteritis': [406], 'Gail': [407], 'S.': [408, 423, 431], ',': [410, 414, 417, 421, 425, 428], 'Claire': [411], 'W.': [412], 'Joseph': [415], 'Randi': [418], 'Y.': [419], 'Anthony': [422], 'Menachem': [426], 'Gary': [430], 'Hoffman': [432], 'Metrics': [433], 'Cited': [434], 'byTakayasu': [435], 'patient': [439], 'presenting': [440], 'stroke': [442], 'improvement': [444], 'hemiparesis': [446], 'following': [447], 'vascular': [448], 'bypass': [449], 'surgery:': [450], 'A': [451], 'case': [452], 'reportCerebral': [453], 'involvement': [454], 'systemic': [456], 'vasculitidesTakayasu': [457], 'arteritisTetracyclines,': [458], 'Glycylcyclines,': [459], 'ChloramphenicolAcknowledged': [461], 'Signatures': [462], 'Metalloproteinases': [465, 481], 'Takayasu’s': [467], 'ArteritisManagement': [468], 'options': [469], 'arteritisExtracellular': [472], 'Remodeling': [474], "Takayasu's": [476], 'Arteritis:': [477], 'Role': [478], 'Adventitial': [483], 'InflammationTransient': [484], 'Ischemic': [485], 'Attacks': [486], "22-Year-OldTakayasu's": [489], 'arteritisCollagen': [490], 'Vascular': [491], 'Infectious': [493], 'DiseasesMinocyclineTakayasu': [494], 'arteritis—advances': [495], 'diagnosis': [497], 'managementEffect': [499], 'an': [501], 'Antimicrobial': [502], 'Agent': [503], 'on': [504], 'Atherosclerotic': [505], "PlaquesTakayasu's": [506], 'ArteritisTakayasu’s': [507], 'disease:': [508], 'reviewTakayasu’s': [510], 'arteritisGiant': [511], 'cell': [512], 'arteritisCurrent': [515], 'World': [516], 'Literature': [517], '6': [518, 529, 534], '2005Volume': [520], '143,': [521], 'Issue': [522, 532], '5Page:': [523], '394-395KeywordsAntimicrobialsC-reactive': [524], 'proteinsHospital': [525], 'medicineImmunosuppressivesPathogenesisRheumatoid': [526], 'arthritisRheumatologySteroidsVasculitis': [527], 'ePublished:': [528], '2005': [531, 536, 541], 'Published:': [533], 'Copyright': [537], '&': [538], 'PermissionsCopyright': [539], '©': [540], 'Physicians.': [546], 'All': [547], 'Rights': [548], 'Reserved.PDF': [549], 'downloadLoading': [550], '...': [551]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2126945620', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-09-12T20:18:49.853612', 'created_date': '2016-06-24'}