Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2126798381', 'doi': 'https://doi.org/10.4049/jimmunol.181.12.8237', 'title': 'Inhibition of Tumor Growth by NK1.1+ Cells and CD8+ T Cells Activated by IL-15 through Receptor β/Common γ Signaling in <i>trans</i>', 'display_name': 'Inhibition of Tumor Growth by NK1.1+ Cells and CD8+ T Cells Activated by IL-15 through Receptor β/Common γ Signaling in <i>trans</i>', 'publication_year': 2008, 'publication_date': '2008-12-15', 'ids': {'openalex': 'https://openalex.org/W2126798381', 'doi': 'https://doi.org/10.4049/jimmunol.181.12.8237', 'mag': '2126798381', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19050240', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3071607'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.181.12.8237', 'pdf_url': 'https://journals.aai.org/jimmunol/article-pdf/181/12/8237/1252679/zim02408008237.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://journals.aai.org/jimmunol/article-pdf/181/12/8237/1252679/zim02408008237.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5044753697', 'display_name': 'Jesse W. Rowley', 'orcid': 'https://orcid.org/0000-0003-4444-1724'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jesse Rowley', 'raw_affiliation_strings': ['*Pathology,', 'Department of'], 'affiliations': [{'raw_affiliation_string': '*Pathology,', 'institution_ids': []}, {'raw_affiliation_string': 'Department of', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021637798', 'display_name': 'Archana Monie', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Archana Monie', 'raw_affiliation_strings': ['*Pathology,', 'Department of'], 'affiliations': [{'raw_affiliation_string': '*Pathology,', 'institution_ids': []}, {'raw_affiliation_string': 'Department of', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003534152', 'display_name': 'Chien‐Fu Hung', 'orcid': 'https://orcid.org/0000-0001-9170-7797'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chien-Fu Hung', 'raw_affiliation_strings': ['*Pathology,', 'Department of', '§Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21231'], 'affiliations': [{'raw_affiliation_string': '*Pathology,', 'institution_ids': []}, {'raw_affiliation_string': 'Department of', 'institution_ids': []}, {'raw_affiliation_string': '§Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21231', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5006924305', 'display_name': 'T.‐C. Wu', 'orcid': 'https://orcid.org/0000-0003-1623-4584'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'T.-C. Wu', 'raw_affiliation_strings': ['*Pathology,', 'Department of', 'Department of Molecular Microbiology and Immunology, and', 'Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21231', '§Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21231', '†Department of Obstetrics and Gynecology,'], 'affiliations': [{'raw_affiliation_string': '*Pathology,', 'institution_ids': []}, {'raw_affiliation_string': '†Department of Obstetrics and Gynecology,', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Molecular Microbiology and Immunology, and', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21231', 'institution_ids': ['https://openalex.org/I145311948']}, {'raw_affiliation_string': '§Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21231', 'institution_ids': ['https://openalex.org/I145311948']}, {'raw_affiliation_string': 'Department of', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.559, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 29, 'citation_normalized_percentile': {'value': 0.801075, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '181', 'issue': '12', 'first_page': '8237', 'last_page': '8247'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10981', 'display_name': 'Cytomegalovirus and herpesvirus research', 'score': 0.985, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12159', 'display_name': 'T-cell and Retrovirus Studies', 'score': 0.973, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/interleukin-3', 'display_name': 'Interleukin 3', 'score': 0.60320324}, {'id': 'https://openalex.org/keywords/zap70', 'display_name': 'ZAP70', 'score': 0.5121703}, {'id': 'https://openalex.org/keywords/interleukin-15', 'display_name': 'Interleukin 15', 'score': 0.4634592}], 'concepts': [{'id': 'https://openalex.org/C129374314', 'wikidata': 'https://www.wikidata.org/wiki/Q909381', 'display_name': 'Interleukin 21', 'level': 4, 'score': 0.69237065}, {'id': 'https://openalex.org/C154317977', 'wikidata': 'https://www.wikidata.org/wiki/Q376266', 'display_name': 'Cytotoxic T cell', 'level': 3, 'score': 0.6532781}, {'id': 'https://openalex.org/C149532602', 'wikidata': 'https://www.wikidata.org/wiki/Q2409681', 'display_name': 'Interleukin 12', 'level': 4, 'score': 0.6063876}, {'id': 'https://openalex.org/C131665280', 'wikidata': 'https://www.wikidata.org/wiki/Q14866169', 'display_name': 'Interleukin 3', 'level': 5, 'score': 0.60320324}, {'id': 'https://openalex.org/C167672396', 'wikidata': 'https://www.wikidata.org/wiki/Q417800', 'display_name': 'CD8', 'level': 3, 'score': 0.5344469}, {'id': 'https://openalex.org/C139563560', 'wikidata': 'https://www.wikidata.org/wiki/Q224930', 'display_name': 'Natural killer T cell', 'level': 4, 'score': 0.5296568}, {'id': 'https://openalex.org/C120642132', 'wikidata': 'https://www.wikidata.org/wiki/Q14907110', 'display_name': 'ZAP70', 'level': 5, 'score': 0.5121703}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5039517}, {'id': 'https://openalex.org/C79484868', 'wikidata': 'https://www.wikidata.org/wiki/Q5971673', 'display_name': 'IL-2 receptor', 'level': 4, 'score': 0.48229957}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.46921647}, {'id': 'https://openalex.org/C98119934', 'wikidata': 'https://www.wikidata.org/wiki/Q14907167', 'display_name': 'Interleukin 15', 'level': 4, 'score': 0.4634592}, {'id': 'https://openalex.org/C67662055', 'wikidata': 'https://www.wikidata.org/wiki/Q1047791', 'display_name': 'Antigen-presenting cell', 'level': 4, 'score': 0.45956045}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.42703477}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.34440297}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.32762736}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.19920331}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.15464696}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.106906444}], 'mesh': [{'descriptor_ui': 'D000950', 'descriptor_name': 'Antigens, Ly', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D018414', 'descriptor_name': 'CD8-Positive T-Lymphocytes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D006131', 'descriptor_name': 'Growth Inhibitors', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D053631', 'descriptor_name': 'Interleukin Receptor Common gamma Subunit', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D019409', 'descriptor_name': 'Interleukin-15', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D053646', 'descriptor_name': 'Interleukin-2 Receptor beta Subunit', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D007694', 'descriptor_name': 'Killer Cells, Natural', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D055651', 'descriptor_name': 'NK Cell Lectin-Like Receptor Subfamily B', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D010051', 'descriptor_name': 'Ovarian Neoplasms', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017951', 'descriptor_name': 'Antigen Presentation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017951', 'descriptor_name': 'Antigen Presentation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000950', 'descriptor_name': 'Antigens, Ly', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000950', 'descriptor_name': 'Antigens, Ly', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D018414', 'descriptor_name': 'CD8-Positive T-Lymphocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018414', 'descriptor_name': 'CD8-Positive T-Lymphocytes', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D018414', 'descriptor_name': 'CD8-Positive T-Lymphocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006131', 'descriptor_name': 'Growth Inhibitors', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D006131', 'descriptor_name': 'Growth Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053631', 'descriptor_name': 'Interleukin Receptor Common gamma Subunit', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D053631', 'descriptor_name': 'Interleukin Receptor Common gamma Subunit', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019409', 'descriptor_name': 'Interleukin-15', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D019409', 'descriptor_name': 'Interleukin-15', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019409', 'descriptor_name': 'Interleukin-15', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019409', 'descriptor_name': 'Interleukin-15', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053720', 'descriptor_name': 'Interleukin-15 Receptor alpha Subunit', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D053720', 'descriptor_name': 'Interleukin-15 Receptor alpha Subunit', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D053720', 'descriptor_name': 'Interleukin-15 Receptor alpha Subunit', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053720', 'descriptor_name': 'Interleukin-15 Receptor alpha Subunit', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D053720', 'descriptor_name': 'Interleukin-15 Receptor alpha Subunit', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D053646', 'descriptor_name': 'Interleukin-2 Receptor beta Subunit', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007694', 'descriptor_name': 'Killer Cells, Natural', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007694', 'descriptor_name': 'Killer Cells, Natural', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007694', 'descriptor_name': 'Killer Cells, Natural', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008213', 'descriptor_name': 'Lymphocyte Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008213', 'descriptor_name': 'Lymphocyte Activation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008213', 'descriptor_name': 'Lymphocyte Activation', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055651', 'descriptor_name': 'NK Cell Lectin-Like Receptor Subfamily B', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D055651', 'descriptor_name': 'NK Cell Lectin-Like Receptor Subfamily B', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010051', 'descriptor_name': 'Ovarian Neoplasms', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D010051', 'descriptor_name': 'Ovarian Neoplasms', 'qualifier_ui': 'Q000821', 'qualifier_name': 'virology', 'is_major_topic': False}, {'descriptor_ui': 'D010051', 'descriptor_name': 'Ovarian Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D010051', 'descriptor_name': 'Ovarian Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012190', 'descriptor_name': 'Retroviridae', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012190', 'descriptor_name': 'Retroviridae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014161', 'descriptor_name': 'Transduction, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.181.12.8237', 'pdf_url': 'https://journals.aai.org/jimmunol/article-pdf/181/12/8237/1252679/zim02408008237.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3071607', 'pdf_url': 'https://europepmc.org/articles/pmc3071607?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071607', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19050240', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.181.12.8237', 'pdf_url': 'https://journals.aai.org/jimmunol/article-pdf/181/12/8237/1252679/zim02408008237.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 48, 'referenced_works': ['https://openalex.org/W1480720178', 'https://openalex.org/W1539591812', 'https://openalex.org/W1566505170', 'https://openalex.org/W1567604499', 'https://openalex.org/W1570245632', 'https://openalex.org/W1576522185', 'https://openalex.org/W1664430667', 'https://openalex.org/W1790397959', 'https://openalex.org/W1829424702', 'https://openalex.org/W1915573248', 'https://openalex.org/W1967818875', 'https://openalex.org/W1970080316', 'https://openalex.org/W1970563382', 'https://openalex.org/W1995297089', 'https://openalex.org/W2006073656', 'https://openalex.org/W2008984410', 'https://openalex.org/W2015192757', 'https://openalex.org/W2019102370', 'https://openalex.org/W2020313517', 'https://openalex.org/W2026274426', 'https://openalex.org/W2028091596', 'https://openalex.org/W2031929209', 'https://openalex.org/W2033222990', 'https://openalex.org/W2033402747', 'https://openalex.org/W2040914801', 'https://openalex.org/W2041636434', 'https://openalex.org/W2047102094', 'https://openalex.org/W2050098572', 'https://openalex.org/W2050723571', 'https://openalex.org/W2057883883', 'https://openalex.org/W2059542392', 'https://openalex.org/W2083778754', 'https://openalex.org/W2084599508', 'https://openalex.org/W2091824579', 'https://openalex.org/W2095138364', 'https://openalex.org/W2097272638', 'https://openalex.org/W2097937083', 'https://openalex.org/W2112744121', 'https://openalex.org/W2114449856', 'https://openalex.org/W2122797835', 'https://openalex.org/W2130204211', 'https://openalex.org/W2137564018', 'https://openalex.org/W2141474436', 'https://openalex.org/W2142285575', 'https://openalex.org/W2148343285', 'https://openalex.org/W2152380932', 'https://openalex.org/W2156449737', 'https://openalex.org/W2171249989'], 'related_works': ['https://openalex.org/W4235353359', 'https://openalex.org/W2605394274', 'https://openalex.org/W2552812348', 'https://openalex.org/W2388776418', 'https://openalex.org/W2350222396', 'https://openalex.org/W2229058835', 'https://openalex.org/W2126519126', 'https://openalex.org/W2071127998', 'https://openalex.org/W2037351868', 'https://openalex.org/W1997279356'], 'abstract_inverted_index': {'Abstract': [0], 'IL-15': [1, 19, 56, 73], 'is': [2], 'an': [3, 210], 'important': [4, 127, 211], 'cytokine': [5], 'involved': [6], 'in': [7, 103, 109, 113, 128, 153, 174, 180, 185, 213, 224], 'the': [8, 29, 47, 52, 81, 104, 154, 170, 186, 202, 214], 'survival': [9], 'and': [10, 16, 32, 42, 60, 98, 122, 140, 176, 219], 'function': [11, 53], 'of': [12, 54, 83, 92, 106, 131, 137, 142, 172, 201, 216, 228], 'CD8+': [13, 43, 61, 99, 123, 177, 220], 'T': [14, 44, 62, 100, 124, 178, 221], 'cells': [15, 41, 59, 63, 67, 87, 121, 125, 139, 167, 179, 218], 'NK': [17, 40, 58, 94, 175, 217], 'cells.': [18, 45, 190], 'can': [20], 'be': [21], 'presented': [22], 'by': [23, 147], 'IL-15Rα': [24], '(IL-15RA)': [25], 'to': [26, 75, 89, 169], 'bind': [27], 'with': [28, 69], 'shared': [30, 203], 'IL-2/IL-15Rβ': [31], 'common': [33, 155, 197], 'γ-chains,': [34], 'which': [35, 182], 'activate': [36], 'signaling': [37, 206], 'pathways': [38], 'on': [39, 57, 85, 159], 'In': [46], 'present': [48], 'study,': [49], 'we': [50], 'characterized': [51], 'trans-presented': [55], 'using': [64], 'TC-1': [65, 86, 166, 189], 'tumor': [66, 107, 132, 143, 229], 'transduced': [68], 'a': [70, 148], 'retrovirus': [71], 'encoding': [72], 'linked': [74], 'IL-15RA': [76], '(IL-15/IL-15RA).': [77], 'We': [78, 161], 'demonstrated': [79, 118], 'that': [80, 119, 164, 196], 'expression': [82], 'IL-15/IL-15RA': [84, 225], 'led': [88, 168], 'increased': [90], 'percentages': [91], 'tumor-infiltrating': [93], 'cells,': [95, 97, 101, 222], 'NKT': [96], 'resulting': [102, 223], 'inhibition': [105, 130, 141, 227], 'growth': [108, 144], 'challenged': [110], 'mice.': [111], 'Additionally,': [112], 'vivo': [114], 'Ab': [115], 'depletion': [116], 'experiments': [117], 'NK1.1+': [120], 'were': [126], 'this': [129, 135], 'growth.': [133, 230], 'Furthermore,': [134], 'accumulation': [136], 'immune': [138], 'was': [145, 183], 'abolished': [146, 184], 'single': [149], 'amino': [150], 'acid': [151], 'mutation': [152], 'γ-chain': [156, 198], 'binding': [157], 'site': [158], 'IL-15.': [160], 'also': [162], 'observed': [163], 'IL-15/IL-15RA-transduced': [165, 188], 'activation': [171, 200, 215], 'STAT5': [173], 'trans,': [181], 'mutated': [187], 'Taken': [191], 'together,': [192], 'our': [193], 'data': [194], 'suggest': [195], 'binding-dependent': [199], 'IL-15/IL-2Rβ/common': [204], 'γ': [205], 'pathway': [207], 'may': [208], 'play': [209], 'role': [212], 'trans-presentation-mediated': [226]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2126798381', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-13T16:23:19.884182', 'created_date': '2016-06-24'}