Serum and Urine Metabolite Profiling Reveals Potential Biomarkers of Human Hepatocellular Carcinoma

Name: Work Video:
Duration: 3 min 30 s
Tianlu Chen; Guoxiang Xie; Xiaoying Wang; Jia Fan; Yunping Qiu; Xiaojiao Zheng; Xin Qi; Yu Cao; Mingming Su; Xiaoyan Wang; Lisa X. Xu; Yun Yen; Ping Liu; Jia Wang
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3498, 3562, 3613, 3621, 3681, 3689, 3701, 3755, 3850, 3894, 3952, 4003, 4011, 4072, 4080, 4092, 4135, 4165, 4167, 4196, 4229, 4248, 4469], 'world': [9, 318], 'with': [10, 79, 119, 218, 225, 257, 264, 278, 319, 388, 428, 527, 534, 566, 573, 587, 714, 976, 1094, 1676, 1878, 2065, 2118, 2121, 2128, 2132, 2136, 2143, 2229, 2232, 2239, 2243, 2247, 2254, 2458, 2695, 2724, 2834, 2872, 2963, 3102, 3123, 3174, 3189, 3196, 3220, 3287, 3302, 3320, 3332, 3350, 3537, 3581, 3589, 3637, 3657, 3672, 3720, 3927, 3971, 3979, 4027, 4048, 4063, 4111], 'high': [11, 175, 320, 484, 935, 1099, 1154, 1636, 2374], 'morbidity': [12, 321, 753, 927], 'and': [13, 48, 67, 72, 91, 107, 121, 129, 153, 167, 174, 203, 207, 221, 228, 235, 237, 252, 260, 304, 322, 357, 376, 381, 400, 416, 430, 438, 462, 476, 483, 512, 516, 530, 537, 544, 546, 561, 569, 613, 674, 690, 735, 759, 774, 824, 844, 902, 924, 928, 944, 956, 979, 1011, 1062, 1102, 1127, 1199, 1252, 1276, 1337, 1362, 1369, 1389, 1547, 1572, 1586, 1614, 1690, 1701, 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449], 'metabolic': [141, 450, 845, 1283, 1304, 1537, 1854, 1875, 2060], 'pathways': [142, 451], 'bile': [145, 164, 191, 211, 454, 473, 500, 520, 2138, 2249], 'acids,': [146, 149, 165, 455, 458, 474], 'free': [147, 456], 'fatty': [148, 457], 'glycolysis,': [150, 459], 'urea': [151, 460, 1182], 'cycle,': [152, 461], 'methionine': [154, 463], 'metabolism.': [155, 464], 'Differentially': [156, 465], 'expressed': [157, 466], 'subjects,': [161, 470], 'histidine,': [166, 475], 'inosine': [168, 477], 'are': [169, 255, 478, 564, 1092, 1849, 2403], 'great': [171, 480], 'significance': [173, 482, 2369], 'fold': [176, 485], 'changes,': [177, 486], 'which': [178, 487], 'warrant': [179, 488], 'further': [180, 489], 'validation': [181, 490], 'HCC.': [186, 495], 'However,': [187, 496, 797], 'alterations': [188, 497], 'acids': [192, 212, 501, 521], 'seem': [193, 502], 'be': [195, 504], 'affected': [196, 505], 'condition': [199, 508], 'hepatitis.': [204, 261, 513, 570], 'Quantitative': [205, 514], 'measurement': [206, 515], 'comparison': [208, 517], 'seven': [210, 519], 'among': [213, 522, 2182, 2191, 2268, 2277], 'hepatitis,': [222, 229, 236, 531, 538, 545], 'without': [232, 541, 2206, 2292, 2604], 'revealed': [240, 549], 'that': [241, 292, 550, 601, 1285, 1829, 1932], 'abnormal': [243, 552], 'levels': [244, 553, 2502], 'glycochenodeoxycholic': [246, 555, 4180], 'acid,': [247, 249, 251, 556, 558, 560, 1813, 1815, 1820, 3592, 3982, 4173, 4175, 4177, 4179, 4181, 4183], 'glycocholic': [248, 557, 4185], 'taurocholic': [250, 559, 4176], 'chenodeoxycholic': [253, 562, 4172], 'acid': [254, 563, 1882, 2709, 3584, 3974, 4186], 'associated': [256, 565, 1877], 'alpha': [265, 574, 1087, 1152], 'fetoprotein': [266, 575, 1088, 1153], 'values': [267, 576, 2176, 2262, 2489], 'lower': [268, 577], 'than': [269, 578, 721, 764, 781, 2352, 2491], '20': [270, 579, 765, 2968, 3472], 'ng/ml': [271, 580, 2480, 2493, 3771, 4153], 'successfully': [273, 582], 'differentiated': [274, 583], 'an': [279, 588, 833, 856, 1852, 1858, 2828, 2964, 3190, 3526, 3638, 3916, 4028], 'accuracy': [280, 589], '100%': [282, 591, 3567, 3957], 'panel': [285, 594, 1692], 'markers.': [288, 597], 'Our': [289, 598], 'work': [290, 599, 3790, 4267], 'shows': [291, 600], 'metabolomic': [293, 602, 1495, 1628, 1748, 1860, 1963, 4338, 4457], 'approach': [295, 604, 1602], 'promising': [298, 607], 'screening': [299, 608], 'tool': [300, 609], 'diagnosis': [303, 612, 923, 938, 946, 1008, 1605, 2410], 'stratification': [305, 614], 'patients.': [308, 617], 'Hepatocelluar': [618], '1The': [621], 'abbreviations': [622], 'used': [623, 1081, 3408, 3743, 3753, 4133], 'are:HCCHuman': [624], 'hepatocellular': [625, 871, 903, 1054, 1131, 1147, 1665, 1751, 1793], 'carcinomaFDG-PETfluorodeoxyglucose-positron': [626], 'emission': [627, 1150], 'tomographyAFPalpha': [628], 'fetoproteinHPLChigh': [629], 'chromatographyLC-MSliquid': [632], 'chromatography-mass': [633, 635, 1159, 1162, 3008], 'spectrometryGC-MSgas': [634], 'spectrometryGC-TOFMSgas': [636], 'chromatography-time-of-flight': [637, 1165], 'spectrometryUPLC-QTOFMSultra-performance': [639], 'spectrometryOPLS-DAorthogonal': [644], 'partial': [645, 1175], 'least': [646, 1176], 'squares-discriminant': [647, 1177], 'analysisPCAprincipal': [648], 'component': [649, 1180], 'analysisUCurea': [650], 'cycleVIPvariable': [651], 'importance': [652, 952, 1185], 'projectES+positive': [655], 'ion': [656, 658, 1190, 1193, 2893, 3259, 3574, 3603, 3647, 3687, 3964, 3993, 4030, 4038, 4078], 'modeES–negative': [657], 'modeTMCStrimethylchlorosilaneBSTFABis(trimethylsilyl)': [659], 'trifluoroacetamide.': [660, 1197], 'fifth': [663], 'most': [664, 1079], 'cancer': [666, 922, 933, 1240, 1461, 1967, 2067], '(1El-Serag': [667], 'H.B.': [668, 865, 889], 'Rudolph': [669], 'K.L.': [670], 'carcinoma:': [672, 832, 1132], 'Epidemiology': [673], 'molecular': [675], 'carcinogenesis.Gastroenterology.': [676], '2007;': [677, 1682, 1920, 3015], '132:': [678], '2557-2576Abstract': [679], 'Full': [680, 682, 908, 910], 'Text': [681, 683, 909, 911], 'PDF': [684, 912], 'PubMed': [685, 838, 883, 913, 991, 1071, 1141, 1263, 1324, 1384, 1466, 1509, 1555, 1581, 1621, 1685, 1768, 1805, 1923, 2006, 2681, 3018, 3397, 3829, 4306, 4345, 4422, 4463], 'Scopus': [686, 839, 884, 914, 992, 1072, 1142, 1264, 1325, 1385, 1467, 1510, 1556, 1582, 1622, 1686, 1769, 1806, 1924, 2007, 2682, 3019, 3398, 3830, 4307, 4346, 4423, 4464], '(4514)': [687], 'Google': [688, 750, 841, 886, 916, 994, 1074, 1144, 1266, 1327, 1387, 1469, 1512, 1558, 1584, 1624, 1688, 1771, 1808, 1926, 2009, 2684, 3021, 3400, 3832, 4309, 4348, 4425, 4466], 'Scholar)': [689, 713, 1388, 1625, 1689], 'third': [692], 'leading': [693], 'cause': [694], 'cancer-related': [696], 'death': [697], '(2World': [698], 'Health': [699], 'Organization': [700], 'Mortality': [701], 'Database,': [702], 'WHO': [703], 'Statistical': [704], 'Information': [705], 'System.Available': [706], 'at': [707, 794, 961, 965, 2570, 2581, 2587, 2601, 2740, 2747, 2770, 2796, 2808, 2878, 2917, 2947, 2955, 3077, 3087, 3154, 3293, 3309, 3325, 3461, 3468, 3502, 3522, 3566, 3617, 3654, 3766, 3840, 3846, 3856, 3912, 3956, 4007, 4045, 4148], 'http://www.who.int/whosis/en/Date': [708], 'accessed:': [709], 'March': [710], '19,': [711], '2008Google': [712], 'five-year': [716, 957], 'survival': [717, 958], 'rate': [718, 930, 959, 2882, 2966, 3295, 3323, 3608, 3774, 3998, 4156], 'less': [720, 780], '7%': [722], '(3Kassahun': [723], 'W.T.': [724], 'Fangmann': [725], 'J.': [726, 728, 730, 878, 985, 1065, 1136, 1346, 1411, 1431, 1481, 1518, 1526, 1576, 1743, 2996, 2998, 4393, 4432], 'Harms': [727], 'Hauss': [729], 'Bartels': [731], 'M.': [732, 1109, 1222, 1532, 1891, 1895, 1973, 2648, 2990, 2994, 3364, 3794, 4273, 4316, 4322, 4397, 4399, 4401, 4440], 'Liver': [733, 2217], 'Resection': [734], 'Transplantation': [736], 'Management': [739], 'Carcinoma:': [742], 'A': [743, 1133, 1600, 1746, 2307, 2686, 3205, 3493, 3578, 3594, 3889, 3968, 3984, 4404], 'Review.Exp.': [744], 'Clin.': [745], 'Transplant.': [746], '2006;': [747, 1138, 1552, 1578], '4:': [748], '549-558PubMed': [749], 'Scholar).': [751, 796, 842, 917, 995, 1075, 1145, 1267, 1328, 1927, 2010, 2685, 3022, 3401, 3833, 4349], 'Southeast': [757], 'Asia': [758], 'sub-Saharan': [760], 'Africa': [761], 'greater': [763], 'cases': [766], 'per': [767, 783], '100,000': [768, 784], 'population,': [769], 'whereas': [770, 3163, 3593, 3983], 'North': [772], 'America': [773], 'Western': [775], 'Europe': [776], 'much': [778], 'lower,': [779], '5': [782, 2930, 3494, 3890], 'population': [785, 2381], '(4Fong': [786], 'T.L.': [787, 3810], 'Schoenfield': [788], 'L.J.': [789], 'Carcinoma': [791, 1367], '(Liver': [792], 'Cancer).available': [793], 'http://www.medicinenet.com/liver-cancer/article.htmGoogle': [795], 'dramatically': [799], 'increasing': [800], 'incidence': [801, 858, 869], 'world,': [806], 'especially': [807], 'United': [810, 875], 'States': [811], 'has': [812, 1390, 1632], 'been': [813, 851, 1000, 1633], 'reported': [814, 1857], 'recent': [816, 862], 'years,': [817], 'chronic': [821, 825, 899], 'alcohol': [822], 'use': [823], 'hepatitis': [826], 'C': [827], 'infection': [828], '(5Anthony': [829], 'P.P.': [830], 'overview.Histopathology.': [834], '2001;': [835], '39:': [836], '109-118Crossref': [837], '(119)': [840], 'Diabetic': [843], 'diseases': [846], 'have': [850, 999, 1201, 1929], 'known': [852], 'contribute': [854], 'increased': [857, 1952], 'years': [863, 2322, 2336, 2447], '(6El-Serag': [864], 'Mason': [866], 'A.C.': [867], 'Rising': [868], 'States.N': [876], 'Eng': [877], 'Med.': [879, 987], '1999;': [880, 1321], '340:': [881], '745-750Crossref': [882], '(2721)': [885], 'Scholar,': [887, 1772, 4310, 4426], '7El-Serag': [888], 'Tran': [890], 'T.': [891, 1520, 1741, 1780, 1975, 2650, 3366, 4275, 4403, 4444], 'Everhart': [892], 'J.E.': [893], 'Diabetes': [894], 'increases': [895], 'risk': [897], 'carcinoma.Gastroenterology.': [904], '2004;': [905, 1381, 4419], '126:': [906], '460-468Abstract': [907], '(1022)': [915], 'Despite': [918], 'significant': [919], 'progress': [920], 'treatment,': [925], 'early': [937, 1007], 'still': [940], 'challenge.': [942], 'Early': [943], 'accurate': [945], 'central': [951], 'timely': [954], 'treatment': [955], '(38.1%': [960], 'stage': [962, 966, 2042], 'I,': [963, 2043], '3.9%': [964], 'IV)': [967], '(8Onodera': [968], 'H.': [969, 1658, 1774, 1784, 3802, 4442], 'Ukai': [970], 'K.': [971], 'Minami': [972], 'Y.': [973, 1047, 1419, 1595, 1646, 1656, 1889, 1893, 1897, 1969, 1979, 1981, 2644, 2654, 2656, 2988, 2992, 3360, 3370, 3372, 3798, 4269, 4279, 4281], 'Hepatocellular-Carcinoma': [974], 'Cases': [975], '5-Year': [977], 'Survival': [978], 'Prognostic': [980], 'Factors': [981], 'Affecting': [982], 'Survival-Time.Tohoku': [984], 'Exp.': [986], '1995;': [988], '176:': [989], '203-211Crossref': [990], '(14)': [993], 'Therefore,': [996], 'considerable': [997], 'efforts': [998], 'devoted': [1001], 'patient': [1012], 'stratification.': [1013], 'Glypican-3,': [1014], 'cell': [1016, 1609], 'surface-linked': [1017], 'heparan': [1018], 'sulfate': [1019, 3177], 'proteoglycan,': [1020], 'one': [1022], 'currently': [1029], 'under': [1030], 'investigation': [1031, 1749], '(9Coston': [1034], 'W.M.': [1035], 'Loera': [1036], 'S.': [1037, 1041, 1113, 1425, 1437, 1447, 1487, 1528, 1987, 2662, 3378, 4287, 4438], 'Lau': [1038], 'S.K.': [1039, 1589], 'Ishizawa': [1040], 'Jiang': [1042], 'Z.': [1043, 1735, 4318, 4326], 'Wu': [1044, 1347], 'C.L.': [1045], 'Yen': [1046], 'Weiss': [1048], 'L.M.': [1049, 1403], 'Chu': [1050], 'P.G.': [1051], 'Distinction': [1052], 'hepatic': [1058], 'mimickers': [1059], 'glypican-3': [1061], 'CD34': [1063], 'immunohistochemistry.Am.': [1064], 'Surg.': [1066], 'Pathol.': [1067], '2008;': [1068, 1618, 1765, 4342], '32:': [1069], '433-444Crossref': [1070], '(121)': [1073], 'At': [1076], 'present,': [1077], 'clinically': [1080], 'biomarker': [1083, 1499], '(AFP);': [1089], 'however,': [1090], 'clinicians': [1091], 'unsatisfied': [1093], 'it': [1095], 'its': [1098], 'false': [1100, 1103], 'positive': [1101, 1189, 3573, 3644, 3684, 3963, 4035, 4075], 'negative': [1104, 1192, 3602, 3646, 3686, 3992, 4037, 4077], 'rates': [1105], '(10Colli': [1106], 'A.': [1107, 1115, 1228, 1401, 1423, 1441, 1564, 1899, 1983, 2658, 3374, 4283, 4320, 4395], 'Fraquelli': [1108], 'Casazza': [1110], 'G.': [1111, 1483, 1971, 2646, 3362, 4271, 4312], 'Massironi': [1112], 'Colucci': [1114], 'Conte': [1116], 'D.': [1117, 1435, 1530], 'Duca': [1118], 'P.': [1119, 1524, 4391, 4428], 'Accuracy': [1120], 'ultrasonography,': [1122], 'spiral': [1123], 'CT,': [1124], 'magnetic': [1125, 1247, 1642], 'resonance,': [1126], 'alpha-fetoprotein': [1128], 'diagnosing': [1130], 'systematic': [1134], 'review.Am.': [1135], 'Gastroenterol.': [1137], '101:': [1139], '513-523Crossref': [1140], '(422)': [1143], 'Human': [1146, 1994, 2669, 3385, 4294], 'fluorodeoxyglucose-positron': [1149], 'tomography': [1151], 'ultra-performance': [1168, 1943], 'orthogonal': [1174], 'analysis': [1178, 1181, 1315, 2018, 2978, 3349, 3737, 4128, 4234, 4332, 4356, 4447], 'principal': [1179], 'cycle': [1183], 'variable': [1184], 'project': [1188], 'mode': [1191, 1194, 2826, 2958, 3242, 3342, 3575, 3604, 3688, 3965, 3994, 4142], 'trimethylchlorosilane': [1195], 'Bis(trimethylsilyl)': [1196], 'Genomics': [1198], 'proteomics': [1200, 1338], 'merged': [1202], 'biochemical': [1204], 'tools': [1206], 'provide': [1208], 'important': [1209], 'insight': [1210], 'into': [1211, 2565, 2827, 3131, 3214, 3486, 3506, 3898], 'biology': [1213], 'various': [1215], 'cancers': [1216], '(11Chan': [1217], 'E.C.': [1218], 'Koh': [1219], 'P.K.': [1220], 'Mal': [1221], 'Cheah': [1223], 'P.Y.': [1224], 'Eu': [1225], 'K.W.': [1226], 'Backshall': [1227], 'Cavill': [1229], 'R.': [1230, 1415, 1733, 1776, 4314], 'Nicholson': [1231], 'J.K.': [1232, 1296], 'Keun': [1233], 'H.C.': [1234], 'Metabolic': [1235, 1902, 3820], 'colorectal': [1239, 1966], 'high-resolution': [1242, 1668], 'magic': [1243], 'angle': [1244], 'spinning': [1245, 1639, 1670], 'nuclear': [1246, 1641], 'resonance': [1248, 1643], '(HR-MAS': [1249], 'NMR)': [1250], 'spectroscopy': [1251, 1644, 1673], '(GC/MS).J.': [1257], 'Proteome': [1258, 1680, 2001, 2676, 3392, 4301], 'Res.': [1259, 1551, 1681, 2002, 2677, 3393, 4302], '2009;': [1260, 1463, 1506, 1802, 2003, 2678, 3394, 3826, 4303], '8:': [1261, 2004, 2679, 3395, 4304], '352-361Crossref': [1262], '(387)': [1265], 'Although': [1268], 'these': [1269], 'approaches': [1271, 1496], 'focus': [1272], 'on': [1273, 1750, 1873, 2849], 'upstream': [1274], 'genetic': [1275], 'protein': [1277], 'variations,': [1278], 'captures': [1280], 'global': [1282], 'changes': [1284], 'occur': [1286], 'response': [1288], 'pathological,': [1290], 'environmental': [1291], 'or': [1292, 2203, 2289, 2462, 2540, 3030, 3248, 3645, 4036], 'lifestyle': [1293], 'factors': [1294], '(12Nicholson': [1295], 'Lindon': [1297], 'J.C.': [1298], 'Holmes': [1299], 'E.': [1300], "‘Metabonomics':": [1301], 'Understanding': [1302], 'responses': [1305], 'living': [1307], 'systems': [1308, 1911], 'stimuli': [1311], 'via': [1312], 'biological': [1317, 2095], 'NMR': [1318, 1672], 'spectroscopic': [1319], 'data.Xenobiotica.': [1320], '29:': [1322], '1181-1189Crossref': [1323], '(3309)': [1326], 'Consequently,': [1329], 'complements': [1331], 'information': [1333, 2049, 2101, 2518], 'obtained': [1334, 2419], 'genomics': [1336], '(13Kuo': [1339], 'Y.T.': [1340], 'Li': [1341, 1418, 1647], 'C.W.': [1342], 'Chen': [1343, 1653, 1894, 1974, 2649, 2993, 3365, 3809, 4274], 'C.Y.': [1344], 'Jao': [1345], 'D.K.': [1348], 'Liu': [1349, 1740, 1779, 1896, 2991, 4325], 'G.C.': [1350], 'In': [1351, 2011, 3680, 4071], 'Vivo': [1352], 'Proton': [1353], 'Magnetic': [1354], 'Resonance': [1355], 'Spectroscopy': [1356], 'Large': [1358, 4410], 'Focal': [1359], 'Hepatic': [1360], 'Lesions': [1361], 'hange': [1364], 'Before': [1368], 'After': [1370, 2735, 3045, 3135, 3452], 'Transcatheter': [1371], 'Arterial': [1372], 'Chemoembolization': [1373], 'Using': [1374, 1997, 2672, 3388, 3817, 4297], '3.0-T': [1375], 'MR': [1376], 'Scanner.J.': [1377], 'Magn.': [1378], 'Reson.': [1379], 'Imaging.': [1380], '19:': [1382], '598-604Crossref': [1383], '(91)': [1386], 'already': [1391], 'shown': [1392, 2404], 'promise': [1393], 'identifying': [1395, 4451], 'metabolite-based': [1396], 'prostate': [1399, 1460], '(14Sreekumar': [1400], 'Poisson': [1402], 'Rajendiran': [1404], 'T.M.': [1405], 'Khan': [1406], 'A.P.': [1407], 'Cao': [1408, 1428], 'Q.': [1409], 'Yu': [1410], 'Laxman': [1412], 'B.': [1413, 1427, 4436], 'Mehra': [1414], 'Lonigro': [1416], 'R.J.': [1417], 'Nyati': [1420], 'M.K.': [1421], 'Ahsan': [1422], 'Kalyana-Sundaram': [1424], 'Han': [1426], 'X.': [1429, 1650, 1652, 1745, 1786, 1977, 2652, 3368, 4277, 4324], 'Byun': [1430], 'Omenn': [1432], 'G.S.': [1433], 'Ghosh': [1434], 'Pennathur': [1436], 'Alexander': [1438], 'D.C.': [1439], 'Berger': [1440], 'Shuster': [1442], 'J.R.': [1443], 'Wei': [1444, 1590], 'J.T.': [1445], 'Varambally': [1446], 'Beecher': [1448], 'C.': [1449, 1516, 1648, 1737, 1782], 'Chinnaiyan': [1450], 'A.M.': [1451], 'Metabolomic': [1452, 1787, 4413], 'profiles': [1453], 'delineate': [1454], 'role': [1456], 'sarcosine': [1458], 'progression.Nature.': [1462], '457:': [1464], '910-914Crossref': [1465], '(1768)': [1468], 'Scholar),': [1470, 1513, 1559, 1585, 1809], 'breast': [1471], '(15Woo': [1472], 'H.M.': [1473], 'Kim': [1474, 1486], 'K.M.': [1475], 'Choi': [1476], 'M.H.': [1477], 'Jung': [1478], 'B.H.': [1479], 'Lee': [1480], 'Kong': [1482], 'Nam': [1484], 'S.J.': [1485], 'Bai': [1488], 'S.W.': [1489], 'Chung': [1490], 'B.C.': [1491], 'Mass': [1492, 1535, 1763], 'based': [1494, 3010], "women's": [1502], 'cancers.Clin.': [1503], 'Chim.': [1504, 1800, 3013], 'Acta.': [1505, 1801, 3014], '400:': [1507], '63-69Crossref': [1508], '(155)': [1511], 'ovarian': [1514, 1545, 1548], '(16Denkert': [1515], 'Budczies': [1517], 'Kind': [1519], 'Weichert': [1521], 'W.': [1522, 1654, 1901, 1989, 2664, 3000, 3380, 3812, 4289, 4328], 'Tablack': [1523], 'Sehouli': [1525], 'Niesporek': [1527], 'Könsgen': [1529], 'Dietel': [1531], 'Fiehn': [1533], 'O.': [1534], 'spectrometry-based': [1536], 'reveals': [1539], 'different': [1540, 2066], 'patterns': [1542], 'invasive': [1544], 'carcinomas': [1546], 'borderline': [1549], 'tumors.Cancer': [1550], '66:': [1553], '10795-10804Crossref': [1554], '(327)': [1557], 'brain': [1560, 1573], '(17Petrik': [1561], 'V.': [1562], 'Loosemore': [1563], 'Howe': [1565], 'F.A.': [1566], 'Bell': [1567], 'B.A.': [1568], 'Papadopoulos': [1569], 'M.C.': [1570], 'OMICS': [1571], 'tumour': [1574], 'biomarkers.Br.': [1575], 'Neurosurg.': [1577], '20:': [1579], '275-280Crossref': [1580], '(17)': [1583], 'oral': [1587, 1607, 1611, 1615], '(18Yan': [1588], 'B.J.': [1591], 'Lin': [1592, 1734], 'Z.Y.': [1593], 'Yang': [1594], 'Zhou': [1596], 'Z.T.': [1597], 'Zhang': [1598, 2997], 'W.D.': [1599], 'metabonomic': [1601, 3011], 'squamous': [1608], 'carcinoma,': [1610], 'lichen': [1612], 'planus': [1613], 'leukoplakia.Oral': [1616], 'Oncol.': [1617], '44:': [1619], '477-483Crossref': [1620], '(72)': [1623], 'cancers.': [1626], 'Recently': [1627], 'resolution': [1637, 4382], 'magic-angle': [1638, 1669], '1H': [1640, 1671], '(19Yang': [1645], 'Nie': [1649], 'Feng': [1651], 'Yue': [1655], 'Tang': [1657], 'Deng': [1659, 1736, 1781], 'F.': [1660], 'Metabonomic': [1661], 'studies': [1662], 'data': [1678, 3626, 3712, 3748, 4016, 4103, 4255, 4353, 4446], 'analysis.J.': [1679], '6:': [1683], '2605-2614Crossref': [1684], '(220)': [1687], '13': [1694, 2327], 'differential': [1695, 2073], 'tissue': [1696], 'metabolites,': [1697, 1842], 'including': [1698, 1810, 4171], 'alanine,': [1699], 'leucine': [1700], 'glucose': [1702], 'identified.': [1704], 'Several': [1705], 'markers': [1712, 1958], 'small': [1715], 'number': [1716, 1839, 1954, 2356], '20)': [1722], '(GC-MS,': [1730], 'LC-MS)': [1731], '(20Xue': [1732], 'Dong': [1738, 1777], 'L.': [1739, 1778], 'Wang': [1742, 3795], 'Shen': [1744, 1785], 'chemical': [1755], 'derivatization': [1756, 3005, 3076, 3119, 3139], 'followed': [1757, 2802, 2920], 'chromatography/mass': [1760, 1798], 'spectrometry.Rapid': [1761], 'Commun.': [1762], 'Spectrom.': [1764], '22:': [1766], '3061-3068Crossref': [1767], '(84)': [1770], '21Wu': [1773], 'Xue': [1775], 'Zeng': [1783], 'spectrometry.Anal.': [1799], '648:': [1803], '98-104Crossref': [1804], '(144)': [1807], 'nucleosides,': [1811], 'butanoic': [1812], 'ethanimidic': [1814], 'glycerol,': [1816], 'isoleucine,': [1817], 'valine,': [1818], 'aminomalonic': [1819], 'glycine,': [1821], 'tyrosine,': [1822], 'threonine,': [1823], 'etc.': [1824], 'It': [1825], 'generally': [1827], 'accepted': [1828], 'single': [1831, 2393], 'analytical': [1832, 1847, 1869, 2085], 'technique': [1833], 'could': [1834], 'only': [1835], 'identify': [1836], 'limited': [1838], 'therefore,': [1844], 'multiple': [1845], 'complementary': [1846], 'platforms': [1848], 'needed': [1850], 'enhanced': [1853, 1859], 'visualization.': [1855], 'We': [1856, 1928], 'combined': [1865, 1905], 'GC-MS': [1866, 1906], 'LC-MS': [1868, 1908], 'platform': [1870], '2007': [1872], 'disruption': [1876], 'nephrotoxicity': [1879, 1916], 'aristolochic': [1881, 1914], 'intervention': [1883], 'rat': [1886], 'model': [1887], '(22Ni': [1888], 'Su': [1890, 1972, 2647, 2989, 3363, 3799, 4272, 4315], 'Qiu': [1892, 3803, 4321], 'Zhao': [1898, 1982, 2657, 3373, 3805, 4282, 4319], 'Jia': [1900, 1988, 2663, 2999, 3379, 3811, 4288, 4327], 'provides': [1909], 'understanding': [1912], 'acid-induced': [1915], 'rat.FEBS': [1918], 'Lett.': [1919], '581:': [1921], '707-711Crossref': [1922], '(112)': [1925], 'recently': [1930], 'demonstrated': [1931], 'combination': [1934], '(GC-TOFMS)': [1941], 'quadrupole': [1946], '(UPLC-QTOFMS)': [1950], 'significantly': [1951], '(23Qiu': [1968, 2643, 3359, 4268], 'Cai': [1970, 1986, 2645, 2661, 3361, 3377, 4270, 4286], 'Zheng': [1976, 2651, 3367, 3807, 4276], 'Xu': [1978, 1984, 2653, 2659, 3369, 3375, 4278, 4284, 4317], 'Ni': [1980, 2655, 3371, 3797, 4280], 'L.X.': [1985, 2660, 3376, 4285], 'Serum': [1990, 2546, 2561, 2629, 2665, 3345, 3381, 4222, 4290], 'Profiling': [1992, 2667, 3383, 3821, 4292], 'Colorectal': [1995, 2670, 3386, 4295], 'Cancer': [1996, 2671, 3387, 4296], 'GC-TOFMS': [1998, 2056, 2637, 2673, 2977, 3182, 3389, 4257, 4298, 4355], 'UPLC-QTOFMS.J.': [2000, 2675, 3391, 4300], '4844-4850Crossref': [2005, 2680, 3396, 4305], '(329)': [2008, 2683, 3399, 4308], 'study,': [2013], 'we': [2014], 'conducted': [2015], 'comprehensive': [2017], '177': [2026], 'participants': [2027, 2625], '(71': [2028], 'individuals,': [2030], '24': [2031, 2193, 2222, 2279, 2325], 'patients,': [2035, 2188, 2197, 2274, 2283, 2312], '82': [2037, 2186, 2272, 2310], 'diagnosed': [2040], 'II,': [2044], 'III,': [2045], 'IV,': [2047], 'detailed': [2048], 'listed': [2051], 'Table': [2053, 2406, 2523], 'I)': [2054], 'UPLC-QTOFMS.': [2058], 'stages': [2068], 'comprehensively': [2070], 'investigated.': [2071], 'cross': [2080], 'checked': [2081], 'two': [2084, 2094, 2696, 3137], 'methods': [2086], 'results': [2092], 'specimens,': [2096], 'serum,': [2097], 'urine.Table': [2099], 'IClinical': [2100], 'cohortsHCC': [2104], '82)Benign': [2108], 'patientsa24': [2111], 'include': [2116, 2227], '8': [2117, 2228], 'hemangioma,': [2119, 2230], '6': [2120, 2231], 'focal': [2122, 2233], 'nodular': [2123, 2234], 'hyperplasia': [2124, 2235], 'liver,': [2126, 2237], '4': [2127, 2238, 2588, 3618, 3847, 4008], 'cirrhosis,': [2130, 2241], '2': [2131, 2242, 2913, 3274, 3455], 'cyst,': [2134, 2245], '1': [2135, 2142, 2246, 2253, 2712, 2815, 3326, 3875], 'intrahepatic': [2137, 2248], 'duct': [2139, 2250], 'stone': [2140, 2251], 'recurrent': [2144, 2255], 'hemangioma': [2145, 2256], 'after': [2146, 2257, 3276, 3422], 'surgery.': [2147], '24)Healthy': [2150], 'control': [2151], '71)Age': [2154], '(Mean,': [2155], 'range)55,': [2156], '29–7644,': [2157], '18–6555,': [2158], '42–65': [2159], 'Male/Female55/2713/1139/32Stage': [2160], 'IbTNM': [2161], 'Classification.33': [2162], '(M21/F12)//Stage': [2163], 'IIbTNM': [2164], 'Classification.20': [2165], '(M16/F4)//Stage': [2166], 'IIIbTNM': [2167], 'Classification.22': [2168], '(M13/F9)//Stage': [2169], 'IVbTNM': [2170], 'Classification.7': [2171], '(M5/F2)//AFP': [2172], 'value': [2173], '(mean,': [2174], 'range)cAFP': [2175], 'provided': [2178, 2264, 2520], '52': [2180, 2266, 2313], '(M34/F18)': [2181, 2267], 'total': [2184, 2270, 2308, 2433], '9(M5/F4)': [2190, 2276], 'others': [2198, 2284], 'labeled': [2200, 2286], '“Negative”': [2202, 2288], '“Positive”': [2204, 2290], 'but': [2205, 2291], 'specific': [2208, 2294], 'AFP': [2209, 2261, 2295, 2473, 2488], 'value;': [2210, 2296], 'M,': [2211, 2297], 'male;': [2212, 2298], 'F,': [2213, 2299], 'female.5010.84,': [2214], '1.30–60500.0060.74,': [2215], '1.20–288.20/ALT47.1333.87/AST52.7339.04/': [2216], '(%)80.7725.00/HBsAg': [2219], '(positive': [2220], '%)66.6745.80/a': [2221], 'surgery.b': [2258], 'TNM': [2259], 'Classification.c': [2260], 'female.': [2300], 'Open': [2301], 'table': [2302], 'new': [2305], 'tab': [2306], 'males': [2314, 2328, 2439], '30': [2316, 2733, 2797, 3147], 'females,': [2317, 2331, 2442], 'aged': [2318, 2332, 2443], '29': [2319], '76': [2321], 'old,': [2323, 2337], 'benign,': [2326], '11': [2330], '18': [2333], '65': [2335, 2446], 'enrolled': [2339], 'study.': [2342, 2628], 'proportion': [2344, 2375], 'females': [2346, 2377], 'cohort': [2349], 'higher': [2351, 2490], 'national': [2354], 'average': [2355, 2469], '(the': [2357], 'ratio': [2358, 4208], 'males/females': [2360], 'about': [2362], '3:1)': [2363], 'favor': [2365], 'males.': [2367], 'No': [2368], 'attached': [2371], 'taken': [2386], 'sequentially': [2388], 'presenting': [2389], 'unit.': [2394], 'Patient': [2395], 'characteristics,': [2396], 'staging': [2397], 'other': [2401], 'parameters': [2402], 'I.': [2407], 'pathological': [2412], 'reports': [2413], 'all': [2415, 2558, 2624, 3779, 4161], 'Zhongshan': [2421, 2613], 'Hospital,': [2422], 'Fudan': [2423], 'University,': [2424], 'Shanghai,': [2425], 'China.': [2426], 'Control': [2427], '71': [2435], 'volunteers': [2437], '(39': [2438], '32': [2441], '42': [2444], 'old)': [2448], 'same': [2451], 'sample': [2452, 2692, 3033, 3346, 3782], 'collection': [2453], 'protocol,': [2454], 'any': [2456, 2487, 2605], 'subjects': [2457], 'inflammatory': [2459], 'conditions,': [2460], 'steatohepatitis,': [2461], 'gastrointestinal': [2463], 'tract': [2464], 'disorders': [2465], 'excluded.': [2467], 'level': [2470], 'group': [2477], '5010.84': [2479], 'ranging': [2481], '1.3': [2483], '60,500': [2485, 2492, 2497], 'ng/ml,': [2486], 'recorded': [2495], 'ng/ml.': [2498], 'Ten': [2499], 'enzyme': [2501], 'correlating': [2503], 'function': [2506], 'measured': [2516], '(detailed': [2517], 'supplemental': [2522], 'S1': [2524], 'S2).': [2526], 'Tumor': [2527], 'invasion': [2528, 2542], 'neighboring': [2530], 'organs,': [2531], 'lesion': [2532], 'nature': [2533], 'dimension,': [2535], 'presence': [2537], 'angiolymphatic': [2539], 'perineural': [2541], 'also': [2544], 'recorded.': [2545], 'morning': [2554], 'before': [2555, 2626, 3412], 'breakfast': [2556], 'participants.': [2560], 'placed': [2564], 'clean': [2566], 'tubes': [2567], 'kept': [2569, 2795, 3616, 4006], '−80': [2571, 2602, 3857], '°C': [2572, 2589, 2603, 2798, 2810, 3286, 3292, 3301, 3311, 3524, 3619, 3656, 3671, 3858, 3914, 4009, 4047, 4062], 'until': [2573], 'analysis.': [2574, 3183, 3414, 3492, 3622, 3861, 3888, 4012], 'centrifuged': [2580, 2746, 3150, 3467, 3839], '3000': [2582], 'rpm': [2583, 2749, 3470, 3842], '10': [2585, 2706, 2717, 2738, 2751, 2922, 3288, 3297, 3465, 3844], 'min': [2586, 2739, 2801, 2914, 2945, 3153, 3275, 3736, 3845, 4127], 'remove': [2591], 'suspended': [2592], 'debris,': [2593], 'resulting': [2596, 3851], 'supernatants': [2597, 3852], 'immediately': [2599, 3854], 'stored': [2600, 3460, 3855], 'preservatives.': [2606], 'protocol': [2608, 2986], 'approved': [2610], 'Hospital': [2614], 'Institutional': [2615], 'Review': [2616], 'Board': [2617], 'written': [2619], 'consents': [2620], 'signed': [2622], 'derivatized': [2632, 2776, 2820, 3185], 'subsequently': [2634, 3179, 4245], 'analyzed': [2635, 3188, 4261], 'following': [2638], 'our': [2639, 2983, 3356, 3788, 4264], 'previously': [2640, 2984, 4265], 'published': [2641, 2985, 3357, 4266], 'protocols': [2642], '100': [2687, 3047, 3059, 3112, 3403, 3424, 3448, 3508, 3770, 3900, 4152], 'μl': [2688, 2700, 2707, 2726, 2758, 2783, 2805, 2816, 3025, 3048, 3054, 3060, 3068, 3099, 3113, 3128, 3404, 3425, 3438, 3449, 3495, 3891], 'aliquot': [2689, 2754, 2817, 3026, 3208, 3496, 3892], 'spiked': [2694, 4168], 'internal': [2697, 3434], 'standards': [2698], '(10': [2699], 'l-2-chlorophenylalanine': [2701, 3050, 3431], 'water,': [2703], '0.3': [2704, 3725, 4116], 'mg/ml;': [2705], 'heptadecanoic': [2708], 'methanol,': [2711], 'mg/ml)': [2713], 'vortexed': [2715, 2731, 3145, 3873], 's.': [2718, 2734, 3092], 'mixed': [2720], 'solution': [2721, 2821, 4170], 'extracted': [2723, 4372], '300': [2725, 2757, 3098, 3670, 4061], 'methanol/chloroform': [2728], '(3:1)': [2729], 'storing': [2736], '−20': [2741], '°C,': [2742, 2899, 2901, 2904, 2919, 2929, 2934, 2940, 3848], '10,000': [2748], 'min.': [2752, 2813, 3314, 3473, 3571, 3961], 'An': [2753], 'supernatant': [2759, 3475], 'transferred': [2761, 3485], 'glass': [2764, 3043], 'sampling': [2765, 3488], 'vial': [2766, 2793, 3489], 'vacuum': [2768], 'dry': [2769], 'room': [2771, 3462], 'temperature.': [2772], 'residue': [2774], 'two-step': [2779], 'procedure.': [2780], 'First,': [2781], '80': [2782, 2804, 2918, 3272], 'methoxyamine': [2784], '(15': [2785], 'mg/ml': [2786, 3430], 'pyridine,)': [2788], 'added': [2790, 3039, 3073, 3867], '90': [2800], 'BSTFA': [2806], '(1%TMCS)': [2807], '70': [2809], '60': [2812, 3091], 'Each': [2814, 3023, 3402], 'injected': [2823, 3213, 3897], 'spitless': [2825], 'Agilent': [2829, 2867, 3191, 3234], '6890N': [2830, 3192], 'coupled': [2833, 3195], 'Pegasus': [2836, 3198], 'HT': [2837, 3199], 'spectrometer': [2840, 3202], '(Leco': [2841, 3203], 'Corporation,': [2842], 'St': [2843], 'Joseph,': [2844], 'MI).': [2845], 'Separation': [2846], 'achieved': [2848], 'DB-5MS': [2851, 3216], 'capillary': [2852, 3217, 3690, 4081], 'column': [2853, 3218, 3517, 3534, 3909, 3924], '(30': [2854], 'm': [2855], '×': [2856, 3227, 3510, 3902], '250': [2857, 3228], 'μm': [2858, 3229, 3514, 3906], 'I.D.,': [2859], '0.25-μm': [2860, 3231], 'film': [2861, 3232], 'thickness;': [2862, 3233], '(5%-phenyl)-methylpolysiloxane': [2863], 'bonded': [2864], 'crosslinked;': [2866], 'J&W': [2868, 3235], 'Scientific,': [2869, 3236], 'Folsom,': [2870, 3237], 'CA)': [2871, 3238], 'helium': [2873], 'carrier': [2876, 3318], 'constant': [2880], 'flow': [2881, 3322, 3607, 3661, 3676, 3773, 3997, 4052, 4067, 4155], '1.0': [2884], 'ml/min.': [2885, 3327, 3611, 4001], 'temperature': [2887, 2908, 2925, 3247, 3251, 3261, 3270, 3281, 3463, 3651, 3668, 4042, 4059], 'injection,': [2889, 3277], 'transfer': [2890], 'interface,': [2891], 'source': [2894, 3260, 3640, 3650, 4031, 4041], 'set': [2896, 2911, 3253, 3324, 3653, 3693, 4044, 4084], '270': [2898], '260': [2900, 3255], '200': [2903, 3265], 'respectively.': [2905, 3710, 4101, 4221], 'GC': [2907, 3268, 3279], 'programming': [2909], 'isothermal': [2915], 'heating': [2916], '°C/min': [2923, 2931, 2937, 3304], 'oven': [2924, 3269, 3280], 'ramps': [2926], '180': [2928], '240': [2933, 3291], '25': [2936], '290': [2939, 2948, 3300, 3310], 'final': [2943], '9': [2944], 'maintenance': [2946], '°C.': [2949, 3081, 3266], 'Electron': [2950], 'impact': [2951, 3334], 'ionization': [2952, 3335], '(70': [2953, 3336], 'eV)': [2954, 3337], 'full': [2956, 3340], 'scan': [2957, 3341, 3722, 4113], '(m/z': [2959, 3343, 3758, 4138], '30–600)': [2960], 'used,': [2962], 'acquisition': [2965], 'spectrum/second': [2969], 'TOFMS': [2972], 'setting.': [2973], 'Urine': [2974, 3781], 'processed': [2980, 3785], 'according': [2981, 3354, 3786, 4262], '(24Qiu': [2987], 'Gu': [2995], 'Application': [3001], 'ethyl': [3003, 3070, 3129], 'chloroformate': [3004, 3071, 3130], 'profiling.Anal.': [3012], '583:': [3016], '277-283Crossref': [3017], '(159)': [3020], '600': [3024, 3678, 4069], 'standard': [3028, 4169], 'mixture': [3029, 3441, 3458], 'diluted': [3031, 4190], '(urine/water': [3034], '1:1,': [3036], 'v/v)': [3037], 'screw-top': [3042], 'tube.': [3044], 'adding': [3046, 3423], '(0.1': [3051], 'mg/ml),': [3052], '400': [3053, 3437], 'anhydrous': [3056, 3175], 'ethanol,': [3057], 'pyridine': [3062], 'sample,': [3066], '50': [3067, 3127, 3663, 3708, 3716, 4054, 4099, 4107], 'first': [3075], '20.0': [3078], '±': [3079], '0.1': [3080, 3429], 'pooled': [3083], 'mixtures': [3084, 3143], 'sonicated': [3086], '40': [3088, 3523, 3913], 'kHz': [3089], 'Subsequently,': [3093], 'extraction': [3094, 3411, 3417], 'chloroform,': [3101], 'aqueous': [3104, 3158], 'layer': [3105, 3159, 3167], 'pH': [3106], 'carefully': [3107], 'adjusted': [3108, 3263], '9–10': [3110], 'NaOH': [3115], '(7': [3116], 'm).': [3117], 'procedure': [3120, 3418], 'repeated': [3122], 'addition': [3125], 'aforementioned': [3133], 'products.': [3134], 'successive': [3138], 'steps,': [3140], 'overall': [3142], 's': [3148, 3726, 3732, 4117, 4123], '3': [3152, 3313, 3698, 4089], '3,000': [3155], 'rpm.': [3156], 'aspirated': [3161], 'off,': [3162], 'remaining': [3165], 'chloroform': [3166], 'containing': [3168], 'derivatives': [3169], 'isolated': [3171], 'dried': [3173], 'sodium': [3176], 'subjected': [3180, 3501], 'extracts': [3186, 3211], 'Corporation).': [3204], '1-μl': [3206], 'extract': [3207], 'coated': [3219], '5%': [3221], 'diphenyl': [3222], 'cross-linked': [3223], '95%': [3224], 'dimethylpolysiloxane': [3225], '(30m': [3226], 'i.d.,': [3230], 'split': [3241], '(3:1).': [3243], 'Either': [3244], 'injection': [3246], 'interface': [3250], '°C;': [3256, 3273], 'Initial': [3267], 'raised': [3283], '140': [3285], '°C/min,': [3289, 3298], '15': [3303], 'again,': [3305], 'finally': [3307], 'held': [3308, 3521, 3565, 3911, 3955], 'Helium': [3315], 'measurements': [3329], 'made': [3331], 'electron': [3333], '30–550).': [3344], 'preparation': [3347, 3783], 'UPLC-QTOFMS': [3351, 3413, 3491, 3860, 3887, 4232, 4259], 'report': [3358], 'carried': [3420], 'out': [3421], 'water': [3427, 3580, 3596, 3863, 3970, 3986], '(containing': [3428], 'standard)': [3435], 'methanol': [3443], 'acetonitrile': [3445, 3588, 3600, 3978, 3990], '(5:3)': [3446], 'serum.': [3451], 'vortexing': [3453], 'min,': [3456, 3466, 3546, 3551, 3556, 3561, 3876, 3936, 3941, 3946, 3951], '12,000': [3469], 'filtered': [3477, 3879], 'through': [3478, 3880], 'syringe': [3480, 3882], 'filter': [3481, 3883], '(0.22': [3482, 3884], 'μm)': [3483, 3885], 'pending': [3490, 3859], 'filtrate': [3499, 3895], 'random': [3504], 'order': [3505], 'mm': [3509, 3901], '2.1': [3511, 3903], 'mm,': [3512, 3904], '1.7': [3513, 3905], 'BEH': [3515, 3907], 'C18': [3516, 3908], '(Waters,': [3518], 'Milford,': [3519], 'MA)': [3520], 'system': [3531, 3745, 3921], '(Waters).': [3532, 3922], 'eluted': [3536, 3926], 'linear': [3539, 3929], 'gradient': [3540, 3930], '1–20%': [3542, 3932], 'B': [3543, 3548, 3553, 3558, 3568, 3586, 3598, 3933, 3938, 3943, 3948, 3958, 3976, 3988], 'over': [3544, 3549, 3554, 3559, 3733, 3934, 3939, 3944, 3949, 4124], '0–1': [3545, 3935], '20–70%': [3547, 3937], '1–3': [3550, 3940], '70–85%': [3552, 3942], '3–8': [3555, 3945], '85–100%': [3557, 3947], '8–9': [3560, 3950], 'composition': [3563, 3953], '0.5': [3570, 3960], 'For': [3572, 3962], '(ES+)': [3576, 3966], 'where': [3577, 3967], '0.1%': [3582, 3590, 3972, 3980], 'formic': [3583, 3591, 3973, 3981], '(ES-).': [3605, 3995], '0.4': [3610, 4000], 'All': [3612, 4002], 'during': [3620, 4010], 'spectrometric': [3625, 4015], 'Waters': [3631, 4021], 'Q-TOF': [3632, 4022], 'premier': [3633, 4023], '(Manchester,': [3634, 4024], 'UK)': [3635, 4025], 'equipped': [3636, 4026], 'electrospray': [3639, 4029], 'operating': [3641, 4032], 'either': [3643, 4034], 'mode.': [3648, 4039], '120': [3655, 4046], 'cone': [3659, 3702, 4050, 4093], 'L/h,': [3664, 4055], 'desolvation': [3666, 3674, 4057, 4065], 'L/h.': [3679, 4070], 'case': [3682, 4073], 'voltage': [3691, 3703, 4082, 4094], '3.2': [3695, 4086], 'kV': [3696, 4087], 'kV,': [3699, 4090], '35': [3705, 4096], 'V': [3706, 4097], 'V,': [3709, 4100], 'Centroid': [3711, 4102], '1000': [3718, 4109], 'm/z': [3719, 4110], 'interscan': [3728, 4119], 'delay': [3729, 4120], '0.02': [3731, 4122], '9.5': [3735, 4126], 'time.': [3738, 4129], 'MassLynx': [3739], 'software': [3740, 4364], '(Waters)': [3741, 3910], 'controlling': [3746], 'acquisition.': [3749], 'Leucine': [3750, 4130], 'enkephalin': [3751, 4131], 'lock': [3756, 4136], '556.2771': [3759, 4139], 'ES+': [3761, 4141], '554.2615': [3763, 4144], 'ES-)': [3765], 'concentration': [3768, 4150, 4193, 4240], '0.2': [3776, 4158], 'ml/min': [3777, 4159], 'previous': [3789], '(25Xie': [3791], 'G.X.': [3792], 'Ye': [3793], 'Y.G.': [3796], 'M.M.': [3800], 'Huang': [3801], 'M.F.': [3804], 'A.H.': [3806], 'X.J.': [3808], 'Characterization': [3813], 'Pu-erh': [3815], 'Tea': [3816], 'Chemical': [3818], 'Approaches.J.': [3822], 'Agri.': [3823], 'Food': [3824], 'Chem.': [3825, 4418, 4459], '57:': [3827], '3046-3054Crossref': [3828], '(110)': [3831], '13,000': [3841], 'Ultrapure': [3862], '(500': [3864, 3870], 'μl)': [3865, 3871], 'then': [3878], 'modes': [4079], 'ES-': [4146], 'mode)': [4147], 'To': [4163], 'verify': [4164], 'linearity,': [4166], 'deoxycholic': [4174], 'cholic': [4178], 'lithocholic': [4182], 'prepared': [4188, 4227], 'appropriate': [4192], 'ranges': [4194], 'establishment': [4197], 'calibration': [4199, 4250], 'curves.': [4200], 'limit': [4202, 4213], 'detection': [4204], '(signal': [4205], 'noise': [4207], '(S/N)': [4209], '3)': [4211], 'quantitation': [4215], '(S/N': [4216], '9)': [4218], 'determined,': [4220], 'method': [4230], 'described': [4235], 'above': [4237], 'section.': [4238], 'each': [4242], 'determined': [4246], 'corresponding': [4249], 'curve.': [4251], 'acquired': [4253, 4351], 'MS': [4254, 4331, 4352], '26Xie': [4311], 'Plumb': [4313], 'Long': [4323], 'Ultra-performance': [4329], 'LC/TOF': [4330], 'medicinal': [4334], 'Panax': [4335], 'herbs': [4336], 'research.J.': [4339], 'Sep.': [4340], 'Sci.': [4341], '31:': [4343], '1015-1026Crossref': [4344], '(163)': [4347], 'exported': [4358], 'NetCDF': [4360], 'format': [4361], 'ChromaTOF': [4363], '(version': [4365], '3.30;': [4366], 'Leco': [4367], 'Co.).': [4368], 'CDF': [4369], 'files': [4370], 'custom': [4374], 'scripts': [4375], '(revised': [4376], 'MATLAB': [4377, 4470], 'toolbox': [4378], 'hierarchical': [4379], 'curve': [4381], '(H-MCR),': [4383], 'developed': [4384], 'Par': [4386], 'Jonsson': [4387], 'et': [4388], 'al.': [4389], '(27Jonsson': [4390], 'Gullberg': [4392, 4431], 'Nordström': [4394], 'Kusano': [4396], 'Kowalczyk': [4398], 'Sjöström': [4400, 4439], 'Moritz': [4402, 4443], 'Strategy': [4405], 'Identifying': [4407], 'Differences': [4408], 'Series': [4411], 'Samples': [4414], 'Analyzed': [4415], 'GC/MS.Anal.': [4417], '76:': [4420], '1738-1745Crossref': [4421], '(297)': [4424], '28Jonsson': [4427], 'Johansson': [4429], 'A.I.': [4430], 'Trygg': [4433], 'J.A.J.': [4434], 'Grung': [4435], 'Marklund': [4437], 'Antti': [4441], 'High-throughput': [4445], 'detecting': [4449], 'differences': [4452], 'between': [4453], 'GC/MS-based': [4456], 'analyses.Anal.': [4458], '2005;': [4460], '77:': [4461], '5635-5642Crossref': [4462], '(356)': [4465], 'Scholar))': [4467], '7.0': [4471], '(The': [4472], 'M': [4473]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2126591541', 'counts_by_year': [{'year': 2024, 'cited_by_count': 15}, {'year': 2023, 'cited_by_count': 16}, {'year': 2022, 'cited_by_count': 22}, {'year': 2021, 'cited_by_count': 31}, {'year': 2020, 'cited_by_count': 27}, {'year': 2019, 'cited_by_count': 28}, {'year': 2018, 'cited_by_count': 19}, {'year': 2017, 'cited_by_count': 24}, {'year': 2016, 'cited_by_count': 24}, {'year': 2015, 'cited_by_count': 26}, {'year': 2014, 'cited_by_count': 37}, {'year': 2013, 'cited_by_count': 29}, {'year': 2012, 'cited_by_count': 20}], 'updated_date': '2024-12-30T20:39:50.115433', 'created_date': '2016-06-24'}
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