Publication Information

{'id': 'https://openalex.org/W2126516096', 'doi': 'https://doi.org/10.1200/jco.1994.12.10.2204', 'title': 'Efficacy and safety of granisetron, a selective 5-hydroxytryptamine-3 receptor antagonist, in the prevention of nausea and vomiting induced by high-dose cisplatin.', 'display_name': 'Efficacy and safety of granisetron, a selective 5-hydroxytryptamine-3 receptor antagonist, in the prevention of nausea and vomiting induced by high-dose cisplatin.', 'publication_year': 1994, 'publication_date': '1994-10-01', 'ids': {'openalex': 'https://openalex.org/W2126516096', 'doi': 'https://doi.org/10.1200/jco.1994.12.10.2204', 'mag': '2126516096', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/7931490'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1200/jco.1994.12.10.2204', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S15137598', 'display_name': 'Journal of Clinical Oncology', 'issn_l': '0732-183X', 'issn': ['0732-183X', '1527-7755'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5076594436', 'display_name': 'Rudolph M. Navari', 'orcid': 'https://orcid.org/0000-0002-8513-896X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'R M Navari', 'raw_affiliation_strings': ['Simon-Williamson Clinic, Birmingham, AL 35211.'], 'affiliations': [{'raw_affiliation_string': 'Simon-Williamson Clinic, Birmingham, AL 35211.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012471769', 'display_name': 'Henry G. Kaplan', 'orcid': 'https://orcid.org/0000-0001-9866-5200'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'H G Kaplan', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048487071', 'display_name': 'Richard J. Gralla', 'orcid': 'https://orcid.org/0000-0001-7963-3086'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'R J Gralla', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109085779', 'display_name': 'Steven M. Grunberg', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'S M Grunberg', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060489101', 'display_name': 'Robert H. Palmer', 'orcid': 'https://orcid.org/0000-0002-5402-6930'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'R Palmer', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5054399119', 'display_name': 'David Fitts', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'D Fitts', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 7.779, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 86, 'citation_normalized_percentile': {'value': 0.932053, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '12', 'issue': '10', 'first_page': '2204', 'last_page': '2210'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11785', 'display_name': 'Nausea and vomiting management', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11785', 'display_name': 'Nausea and vomiting management', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12429', 'display_name': 'Chemotherapy-induced organ toxicity mitigation', 'score': 0.9911, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12229', 'display_name': 'Pharmacological Effects and Toxicity Studies', 'score': 0.9675, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/retching', 'display_name': 'Retching', 'score': 0.98663056}, {'id': 'https://openalex.org/keywords/granisetron', 'display_name': 'Granisetron', 'score': 0.9358002}], 'concepts': [{'id': 'https://openalex.org/C2778573518', 'wikidata': 'https://www.wikidata.org/wiki/Q7316656', 'display_name': 'Retching', 'level': 3, 'score': 0.98663056}, {'id': 'https://openalex.org/C2777452722', 'wikidata': 'https://www.wikidata.org/wiki/Q596708', 'display_name': 'Granisetron', 'level': 4, 'score': 0.9358002}, {'id': 'https://openalex.org/C2780884295', 'wikidata': 'https://www.wikidata.org/wiki/Q575136', 'display_name': 'Antiemetic', 'level': 3, 'score': 0.86550343}, {'id': 'https://openalex.org/C2780852908', 'wikidata': 'https://www.wikidata.org/wiki/Q127076', 'display_name': 'Vomiting', 'level': 2, 'score': 0.8527926}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.83438754}, {'id': 'https://openalex.org/C2780580376', 'wikidata': 'https://www.wikidata.org/wiki/Q186889', 'display_name': 'Nausea', 'level': 2, 'score': 0.80422926}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.6981327}, {'id': 'https://openalex.org/C197934379', 'wikidata': 'https://www.wikidata.org/wiki/Q2047938', 'display_name': 'Adverse effect', 'level': 2, 'score': 0.5180781}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.41373438}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.23707017}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.20343322}], 'mesh': [{'descriptor_ui': 'D002945', 'descriptor_name': 'Cisplatin', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D017829', 'descriptor_name': 'Granisetron', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D009325', 'descriptor_name': 'Nausea', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': True}, {'descriptor_ui': 'D014839', 'descriptor_name': 'Vomiting', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': True}, {'descriptor_ui': 'D000293', 'descriptor_name': 'Adolescent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002945', 'descriptor_name': 'Cisplatin', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D002945', 'descriptor_name': 'Cisplatin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003248', 'descriptor_name': 'Constipation', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D003248', 'descriptor_name': 'Constipation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003967', 'descriptor_name': 'Diarrhea', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D003967', 'descriptor_name': 'Diarrhea', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004311', 'descriptor_name': 'Double-Blind Method', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017829', 'descriptor_name': 'Granisetron', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D017829', 'descriptor_name': 'Granisetron', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D017829', 'descriptor_name': 'Granisetron', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006261', 'descriptor_name': 'Headache', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D006261', 'descriptor_name': 'Headache', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007262', 'descriptor_name': 'Infusions, Intravenous', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009325', 'descriptor_name': 'Nausea', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D009325', 'descriptor_name': 'Nausea', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012701', 'descriptor_name': 'Serotonin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012701', 'descriptor_name': 'Serotonin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014481', 'descriptor_name': 'United States', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014839', 'descriptor_name': 'Vomiting', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D014839', 'descriptor_name': 'Vomiting', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1200/jco.1994.12.10.2204', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S15137598', 'display_name': 'Journal of Clinical Oncology', 'issn_l': '0732-183X', 'issn': ['0732-183X', '1527-7755'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/7931490', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.78}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 22, 'referenced_works': ['https://openalex.org/W1955223035', 'https://openalex.org/W1965800829', 'https://openalex.org/W1979300931', 'https://openalex.org/W1979419703', 'https://openalex.org/W1993819171', 'https://openalex.org/W1996898160', 'https://openalex.org/W2002496553', 'https://openalex.org/W2003876327', 'https://openalex.org/W2008666055', 'https://openalex.org/W2060539479', 'https://openalex.org/W2061201489', 'https://openalex.org/W2132030537', 'https://openalex.org/W2153494490', 'https://openalex.org/W2156705799', 'https://openalex.org/W2161618882', 'https://openalex.org/W2209908099', 'https://openalex.org/W2256916390', 'https://openalex.org/W2262162292', 'https://openalex.org/W2264441265', 'https://openalex.org/W2397148965', 'https://openalex.org/W2413914637', 'https://openalex.org/W4285719527'], 'related_works': ['https://openalex.org/W3190131309', 'https://openalex.org/W2368337335', 'https://openalex.org/W2264708798', 'https://openalex.org/W2262162292', 'https://openalex.org/W2087017705', 'https://openalex.org/W2061774332', 'https://openalex.org/W1991636335', 'https://openalex.org/W1983567324', 'https://openalex.org/W1974914954', 'https://openalex.org/W1902422509'], 'abstract_inverted_index': {'PURPOSE': [0], 'To': [1], 'assess': [2], 'the': [3, 188, 194, 210, 266, 270], 'antiemetic': [4, 126, 149, 185], 'effects': [5], 'and': [6, 34, 81, 87, 98, 110, 124, 134, 139, 147, 155, 174, 179, 247, 269, 272], 'safety': [7], 'profile': [8], 'of': [9, 13, 31, 56, 95, 106, 136, 157, 169, 225, 236, 255], 'four': [10, 57], 'different': [11], 'doses': [12, 59, 105, 242], 'granisetron': [14, 58, 104, 199, 226], '(Kytril;': [15], 'SmithKline': [16], 'Beecham': [17], 'Pharmaceuticals,': [18], 'Philadelphia,': [19], 'PA)': [20], 'when': [21], 'administered': [22, 66, 183], 'as': [23], 'a': [24, 113, 140, 162], 'single': [25, 219], 'intravenous': [26], '(IV)': [27], 'dose': [28, 200, 224, 268], 'for': [29, 76], 'prophylaxis': [30], 'cisplatin-induced': [32], 'nausea': [33, 170], 'vomiting.': [35], 'PATIENTS': [36], 'AND': [37], 'METHODS': [38], 'One': [39], 'hundred': [40], 'eighty-four': [41], 'chemotherapy-naive': [42], 'patients': [43, 181, 237], 'receiving': [44], 'high-dose': [45], 'cisplatin': [46, 240], '(81': [47], 'to': [48, 53, 78, 166, 234, 253], '120': [49], 'mg/m2)': [50], 'were': [51, 70, 89, 182, 258], 'randomized': [52], 'receive': [54], 'one': [55], '(5,': [60], '10,': [61, 108], '20,': [62, 109], 'or': [63, 117, 121, 145, 222], '40': [64, 111], 'micrograms/kg)': [65], 'before': [67], 'chemotherapy.': [68], 'Patients': [69], 'observed': [71], 'on': [72], 'an': [73], 'inpatient': [74], 'basis': [75], '18': [77], '24': [79], 'hours,': [80], 'vital': [82], 'signs,': [83], 'nausea,': [84], 'vomiting,': [85], 'retching,': [86, 146], 'appetite': [88, 202], 'assessed.': [90], 'Safety': [91], 'analyses': [92], 'included': [93], 'incidence': [94], 'adverse': [96, 214], 'experiences': [97], 'laboratory': [99], 'parameter': [100], 'changes.': [101], 'RESULTS': [102], 'After': [103], '5,': [107], 'micrograms/kg,': [112], 'major': [114], 'response': [115, 142], '(<': [116], '=': [118, 172, 177, 206], 'two': [119], 'vomiting': [120, 144, 175, 231, 250], 'retching': [122], 'episodes,': [123], 'no': [125, 148, 259], 'rescue)': [127, 150], 'was': [128, 161, 209, 227, 276], 'recorded': [129], 'in': [130, 151, 187, 193, 229, 232, 251, 263], '23%,': [131], '57%,': [132], '58%,': [133], '60%': [135, 235], 'patients,': [137, 158], 'respectively,': [138], 'complete': [141], '(no': [143], '18%,': [152], '41%,': [153], '40%,': [154], '47%': [156, 254], 'respectively.': [159], 'There': [160, 257], 'statistically': [163, 260], 'longer': [164], 'time': [165], 'first': [167], 'episode': [168], '(P': [171, 176, 205], '.0015)': [173], '.0001),': [178], 'fewer': [180], 'additional': [184], 'medication': [186], '10-micrograms/kg': [189, 267], 'dosing': [190, 196], 'groups': [191], 'than': [192, 244], '5-micrograms/kg': [195], 'group.': [197], 'As': [198], 'increased,': [201], 'return': [203], 'increased': [204], '.040).': [207], 'Headache': [208], 'most': [211], 'frequently': [212], 'reported': [213], 'event': [215], '(20%).': [216], 'CONCLUSION': [217], 'A': [218], '10-,': [220], '20-,': [221], '40-micrograms/kg': [223, 273], 'effective': [228], 'controlling': [230], '57%': [233], 'who': [238], 'received': [239], 'at': [241, 279], 'greater': [243], '81': [245], 'mg/m2': [246], 'totally': [248], 'prevented': [249], '40%': [252], 'patients.': [256], 'significant': [261], 'differences': [262], 'efficacy': [264], 'between': [265], '20-': [271], 'doses.': [274, 281], 'Granisetron': [275], 'well': [277], 'tolerated': [278], 'all': [280]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2126516096', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2025-01-10T01:38:23.142619', 'created_date': '2016-06-24'}