Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2126515754', 'doi': 'https://doi.org/10.1128/jvi.73.12.10489-10502.1999', 'title': 'Consistent Viral Evolutionary Changes Associated with the Progression of Human Immunodeficiency Virus Type 1 Infection', 'display_name': 'Consistent Viral Evolutionary Changes Associated with the Progression of Human Immunodeficiency Virus Type 1 Infection', 'publication_year': 1999, 'publication_date': '1999-12-01', 'ids': {'openalex': 'https://openalex.org/W2126515754', 'doi': 'https://doi.org/10.1128/jvi.73.12.10489-10502.1999', 'mag': '2126515754', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10559367', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/113104'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/jvi.73.12.10489-10502.1999', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S96615428', 'display_name': 'Journal of Virology', 'issn_l': '0022-538X', 'issn': ['0022-538X', '1070-6321', '1098-5514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1128/jvi.73.12.10489-10502.1999', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5042390260', 'display_name': 'Raj Shankarappa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Raj Shankarappa', 'raw_affiliation_strings': ['Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195-77401;'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195-77401;', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012245215', 'display_name': 'Joseph B. Margolick', 'orcid': 'https://orcid.org/0000-0002-4210-9093'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Joseph B. Margolick', 'raw_affiliation_strings': ['Departments of Molecular Microbiology and Immunology2 and of'], 'affiliations': [{'raw_affiliation_string': 'Departments of Molecular Microbiology and Immunology2 and of', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017756604', 'display_name': 'Stephen J. Gange', 'orcid': 'https://orcid.org/0000-0001-7842-512X'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stephen J. Gange', 'raw_affiliation_strings': ['Epidemiology3, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205; and'], 'affiliations': [{'raw_affiliation_string': 'Epidemiology3, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205; and', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015045944', 'display_name': 'Allen G. Rodrigo', 'orcid': 'https://orcid.org/0000-0002-8327-7317'}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Allen G. Rodrigo', 'raw_affiliation_strings': ['Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195-77401;'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195-77401;', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021333124', 'display_name': 'David A. Upchurch', 'orcid': 'https://orcid.org/0000-0001-7409-3957'}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David Upchurch', 'raw_affiliation_strings': ['Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195-77401;'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195-77401;', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009228936', 'display_name': 'Homayoon Farzadegan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Homayoon Farzadegan', 'raw_affiliation_strings': ['Epidemiology3, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205; and'], 'affiliations': [{'raw_affiliation_string': 'Epidemiology3, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205; and', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100716721', 'display_name': 'Phalguni Gupta', 'orcid': 'https://orcid.org/0000-0003-2427-3700'}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Phalguni Gupta', 'raw_affiliation_strings': ['Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Medicine and Graduate School of Public Health, Pittsburgh, Pennsylvania 152134'], 'affiliations': [{'raw_affiliation_string': 'Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Medicine and Graduate School of Public Health, Pittsburgh, Pennsylvania 152134', 'institution_ids': ['https://openalex.org/I170201317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002926065', 'display_name': 'Charles R. Rinaldo', 'orcid': 'https://orcid.org/0000-0002-9194-3164'}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Charles R. Rinaldo', 'raw_affiliation_strings': ['Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Medicine and Graduate School of Public Health, Pittsburgh, Pennsylvania 152134'], 'affiliations': [{'raw_affiliation_string': 'Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Medicine and Graduate School of Public Health, Pittsburgh, Pennsylvania 152134', 'institution_ids': ['https://openalex.org/I170201317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043408832', 'display_name': 'Gerald H. Learn', 'orcid': 'https://orcid.org/0000-0003-0434-7733'}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gerald H. Learn', 'raw_affiliation_strings': ['Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195-77401;'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195-77401;', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028289642', 'display_name': 'Xi He', 'orcid': 'https://orcid.org/0000-0003-2676-9742'}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xi He', 'raw_affiliation_strings': ['Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195-77401;'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195-77401;', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100888801', 'display_name': 'Xiao-Li Huang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xiao-Li Huang', 'raw_affiliation_strings': ['Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Medicine and Graduate School of Public Health, Pittsburgh, Pennsylvania 152134'], 'affiliations': [{'raw_affiliation_string': 'Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Medicine and Graduate School of Public Health, Pittsburgh, Pennsylvania 152134', 'institution_ids': ['https://openalex.org/I170201317']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5028336562', 'display_name': 'James I. Mullins', 'orcid': 'https://orcid.org/0000-0002-4461-8158'}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James I. Mullins', 'raw_affiliation_strings': ['Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195-77401;'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195-77401;', 'institution_ids': ['https://openalex.org/I201448701']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 5.992, 'has_fulltext': False, 'cited_by_count': 960, 'citation_normalized_percentile': {'value': 0.96422, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '73', 'issue': '12', 'first_page': '10489', 'last_page': '10502'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10112', 'display_name': 'HIV Research and Treatment', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2406', 'display_name': 'Virology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10112', 'display_name': 'HIV Research and Treatment', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2406', 'display_name': 'Virology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 0.9919, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10031', 'display_name': 'T-cell and B-cell Immunology', 'score': 0.9836, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/seroconversion', 'display_name': 'Seroconversion', 'score': 0.5034532}, {'id': 'https://openalex.org/keywords/viral-evolution', 'display_name': 'Viral evolution', 'score': 0.49607977}, {'id': 'https://openalex.org/keywords/divergence', 'display_name': 'Divergence (linguistics)', 'score': 0.43950653}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.83604527}, {'id': 'https://openalex.org/C2777910003', 'wikidata': 'https://www.wikidata.org/wiki/Q1707292', 'display_name': 'Asymptomatic', 'level': 2, 'score': 0.52814037}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.5221734}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.51600766}, {'id': 'https://openalex.org/C2777451964', 'wikidata': 'https://www.wikidata.org/wiki/Q2141450', 'display_name': 'Seroconversion', 'level': 3, 'score': 0.5034532}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.5017257}, {'id': 'https://openalex.org/C8769409', 'wikidata': 'https://www.wikidata.org/wiki/Q2066554', 'display_name': 'Viral evolution', 'level': 4, 'score': 0.49607977}, {'id': 'https://openalex.org/C142462285', 'wikidata': 'https://www.wikidata.org/wiki/Q2528140', 'display_name': 'Viral load', 'level': 3, 'score': 0.48927018}, {'id': 'https://openalex.org/C207390915', 'wikidata': 'https://www.wikidata.org/wiki/Q1230525', 'display_name': 'Divergence (linguistics)', 'level': 2, 'score': 0.43950653}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.41812927}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.30580363}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.1935902}, {'id': 'https://openalex.org/C149923435', 'wikidata': 'https://www.wikidata.org/wiki/Q37732', 'display_name': 'Demography', 'level': 1, 'score': 0.17866421}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.17429414}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.06890631}, {'id': 'https://openalex.org/C41895202', 'wikidata': 'https://www.wikidata.org/wiki/Q8162', 'display_name': 'Linguistics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C138885662', 'wikidata': 'https://www.wikidata.org/wiki/Q5891', 'display_name': 'Philosophy', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C141231307', 'wikidata': 'https://www.wikidata.org/wiki/Q7020', 'display_name': 'Genome', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C144024400', 'wikidata': 'https://www.wikidata.org/wiki/Q21201', 'display_name': 'Sociology', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D019143', 'descriptor_name': 'Evolution, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015686', 'descriptor_name': 'Gene Products, env', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D015658', 'descriptor_name': 'HIV Infections', 'qualifier_ui': 'Q000821', 'qualifier_name': 'virology', 'is_major_topic': True}, {'descriptor_ui': 'D015497', 'descriptor_name': 'HIV-1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004279', 'descriptor_name': 'DNA, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018450', 'descriptor_name': 'Disease Progression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015686', 'descriptor_name': 'Gene Products, env', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015658', 'descriptor_name': 'HIV Infections', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D015658', 'descriptor_name': 'HIV Infections', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D015658', 'descriptor_name': 'HIV Infections', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015497', 'descriptor_name': 'HIV-1', 'qualifier_ui': 'Q000145', 'qualifier_name': 'classification', 'is_major_topic': False}, {'descriptor_ui': 'D015497', 'descriptor_name': 'HIV-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011446', 'descriptor_name': 'Prospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/jvi.73.12.10489-10502.1999', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S96615428', 'display_name': 'Journal of Virology', 'issn_l': '0022-538X', 'issn': ['0022-538X', '1070-6321', '1098-5514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc113104', 'pdf_url': 'https://europepmc.org/articles/pmc113104?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC113104', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10559367', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/jvi.73.12.10489-10502.1999', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S96615428', 'display_name': 'Journal of Virology', 'issn_l': '0022-538X', 'issn': ['0022-538X', '1070-6321', '1098-5514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.8, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 84, 'referenced_works': ['https://openalex.org/W1487049617', 'https://openalex.org/W1532718280', 'https://openalex.org/W1539316786', 'https://openalex.org/W1560104174', 'https://openalex.org/W1607005809', 'https://openalex.org/W1623426438', 'https://openalex.org/W1626485058', 'https://openalex.org/W1655510925', 'https://openalex.org/W1664573657', 'https://openalex.org/W1697103163', 'https://openalex.org/W1723922714', 'https://openalex.org/W1739595091', 'https://openalex.org/W1811218957', 'https://openalex.org/W188810783', 'https://openalex.org/W1900729316', 'https://openalex.org/W1961537166', 'https://openalex.org/W1963984954', 'https://openalex.org/W1965071100', 'https://openalex.org/W1965757034', 'https://openalex.org/W1974807329', 'https://openalex.org/W1974839791', 'https://openalex.org/W1976086277', 'https://openalex.org/W1976466060', 'https://openalex.org/W1977279184', 'https://openalex.org/W1980246983', 'https://openalex.org/W1982448824', 'https://openalex.org/W1983466424', 'https://openalex.org/W1987834144', 'https://openalex.org/W2000912207', 'https://openalex.org/W2001328903', 'https://openalex.org/W2005914731', 'https://openalex.org/W2011626958', 'https://openalex.org/W2012139740', 'https://openalex.org/W2018555130', 'https://openalex.org/W2020096299', 'https://openalex.org/W2025948021', 'https://openalex.org/W2032423987', 'https://openalex.org/W2035939192', 'https://openalex.org/W2037747846', 'https://openalex.org/W2044605877', 'https://openalex.org/W2047923627', 'https://openalex.org/W2048499136', 'https://openalex.org/W2051269276', 'https://openalex.org/W2057410806', 'https://openalex.org/W2057812330', 'https://openalex.org/W2064030774', 'https://openalex.org/W2064502505', 'https://openalex.org/W2065461553', 'https://openalex.org/W2070140544', 'https://openalex.org/W2085721436', 'https://openalex.org/W2090642065', 'https://openalex.org/W2097403532', 'https://openalex.org/W2100267080', 'https://openalex.org/W2106915606', 'https://openalex.org/W2112348586', 'https://openalex.org/W2115981562', 'https://openalex.org/W2116258000', 'https://openalex.org/W2116789308', 'https://openalex.org/W2118708820', 'https://openalex.org/W2119630025', 'https://openalex.org/W2121079692', 'https://openalex.org/W2123778842', 'https://openalex.org/W2124175534', 'https://openalex.org/W2125576430', 'https://openalex.org/W2133368465', 'https://openalex.org/W2142809896', 'https://openalex.org/W2143473902', 'https://openalex.org/W2149629952', 'https://openalex.org/W2149910390', 'https://openalex.org/W2153683121', 'https://openalex.org/W2159159834', 'https://openalex.org/W2164640085', 'https://openalex.org/W2165125578', 'https://openalex.org/W2166595456', 'https://openalex.org/W2170821252', 'https://openalex.org/W2171030070', 'https://openalex.org/W2171141994', 'https://openalex.org/W2282756759', 'https://openalex.org/W2312499014', 'https://openalex.org/W2411895135', 'https://openalex.org/W3199943451', 'https://openalex.org/W4240340338', 'https://openalex.org/W4247917425', 'https://openalex.org/W4299615173'], 'related_works': ['https://openalex.org/W4206105795', 'https://openalex.org/W3107681385', 'https://openalex.org/W3088609705', 'https://openalex.org/W2074878346', 'https://openalex.org/W2049776456', 'https://openalex.org/W2026567288', 'https://openalex.org/W2010094066', 'https://openalex.org/W2009307527', 'https://openalex.org/W2000601110', 'https://openalex.org/W1995324211'], 'abstract_inverted_index': {'To': [0], 'understand': [1], 'the': [2, 6, 19, 25, 28, 32, 56, 69, 79, 85, 96, 103, 108, 115, 188, 191, 206, 209, 264, 267, 278, 297], 'high': [3], 'variability': [4], 'of': [5, 21, 27, 31, 37, 49, 58, 63, 71, 81, 98, 101, 110, 123, 148, 175, 190, 222, 236, 245, 274, 280, 287], 'asymptomatic': [7, 116], 'interval': [8, 117], 'between': [9, 208, 249, 299], 'primary': [10], 'human': [11], 'immunodeficiency': [12], 'virus': [13], 'type': [14], '1': [15], '(HIV-1)': [16], 'infection': [17, 282], 'and': [18, 36, 95, 138, 165, 177, 196, 201, 211, 234, 252, 257, 260, 302, 305, 315, 319], 'development': [20, 70], 'AIDS,': [22], 'we': [23], 'studied': [24], 'evolution': [26, 276, 301], 'C2-V5': [29], 'region': [30], 'HIV-1': [33, 281, 321], 'env': [34], 'gene': [35], 'T-cell': [38, 223, 258], 'subsets': [39], 'in': [40, 74, 135, 156, 163, 182, 230, 283, 317], 'nine': [41], 'men': [42], 'with': [43, 159, 220], 'a': [44, 61, 153, 166, 171, 203, 227, 271, 308], 'moderate': [45, 284], 'or': [46, 161, 173, 180], 'slow': [47], 'rate': [48], 'disease': [50, 73, 303], 'progression.': [51], 'They': [52], 'were': [53, 140], 'monitored': [54], 'from': [55, 84], 'time': [57, 93, 189], 'seroconversion': [59], 'for': [60, 311], 'period': [62], '6': [64], 'to': [65, 193, 240], '12': [66], 'years': [67], 'until': [68], 'advanced': [72], 'seven': [75], 'men.': [76], 'Based': [77], 'on': [78, 296], 'analysis': [80], 'viral': [82, 88, 250, 254, 275, 300], 'divergence': [83, 137, 157, 176, 251], 'founder': [86], 'strain,': [87], 'population': [89], 'diversity': [90, 139], 'within': [91, 114], 'sequential': [92], 'points,': [94], 'outgrowth': [97], 'viruses': [99], 'capable': [100], 'utilizing': [102], 'CXCR4': [104], 'receptor': [105], '(X4': [106], 'viruses),': [107], 'existence': [109], 'three': [111], 'distinct': [112], 'phases': [113, 268], 'is': [118], 'suggested:': [119], 'an': [120, 142, 146], 'early': [121], 'phase': [122, 144, 168], 'variable': [124], 'duration': [125], 'during': [126, 277], 'which': [127], 'linear': [128], 'increases': [129], '(': [130], 'approximately': [131], '1%': [132], 'per': [133], 'year)': [134], 'both': [136], 'observed;': [141], 'intermediate': [143, 210], 'lasting': [145], 'average': [147], '1.8': [149], 'years,': [150], 'characterized': [151, 169], 'by': [152, 170, 226], 'continued': [154, 178], 'increase': [155], 'but': [158], 'stabilization': [160, 174], 'decline': [162, 181, 204, 235], 'diversity;': [164], 'late': [167, 212], 'slowdown': [172], 'stability': [179], 'diversity.': [183], 'X4': [184], 'variants': [185], 'emerged': [186], 'around': [187, 205], 'early-': [192], 'intermediate-phase': [194], 'transition': [195, 207, 216], 'then': [197], 'achieved': [198], 'peak': [199], 'representation': [200], 'began': [202], 'phases.': [213], 'The': [214, 243], 'late-phase': [215], 'was': [217], 'also': [218], 'associated': [219], 'failure': [221], 'homeostasis': [224, 259], '(defined': [225], 'downward': [228], 'inflection': [229], 'CD3(+)': [231], 'T': [232, 238], 'cells)': [233], 'CD4(+)': [237], 'cells': [239], '</=200': [241], 'cells/microliter.': [242], 'strength': [244], 'these': [246], 'temporal': [247], 'associations': [248], 'diversity,': [253], 'coreceptor': [255], 'specificity,': [256], 'subset': [261], 'composition': [262], 'supports': [263], 'concept': [265], 'that': [266], 'described': [269], 'represent': [270], 'consistent': [272], 'pattern': [273, 289], 'course': [279], 'progressors.': [285], 'Recognition': [286], 'this': [288], 'may': [290, 306], 'help': [291], 'explain': [292], 'previous': [293], 'conflicting': [294], 'data': [295], 'relationship': [298], 'progression': [304], 'provide': [307], 'useful': [309], 'framework': [310], 'evaluating': [312], 'immune': [313], 'damage': [314], 'recovery': [316], 'untreated': [318], 'treated': [320], 'infections.': [322]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2126515754', 'counts_by_year': [{'year': 2024, 'cited_by_count': 14}, {'year': 2023, 'cited_by_count': 20}, {'year': 2022, 'cited_by_count': 16}, {'year': 2021, 'cited_by_count': 17}, {'year': 2020, 'cited_by_count': 23}, {'year': 2019, 'cited_by_count': 34}, {'year': 2018, 'cited_by_count': 24}, {'year': 2017, 'cited_by_count': 38}, {'year': 2016, 'cited_by_count': 35}, {'year': 2015, 'cited_by_count': 36}, {'year': 2014, 'cited_by_count': 41}, {'year': 2013, 'cited_by_count': 58}, {'year': 2012, 'cited_by_count': 56}], 'updated_date': '2024-12-17T16:38:19.375614', 'created_date': '2016-06-24'}