The human cutaneous circulation as a model of generalized microvascular function

Name: Work Video:
Duration: 3 min 30 s
Lacy A. Holowatz; Caitlin S. Thompson‐Torgerson; W. Larry Kenney
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'capacity': [374, 2058], 'response': [376, 832, 994, 1044, 1159, 1646, 2534], 'metabolic,': [378], 'thermal': [379, 683, 1000], '(reflex': [380], 'locally': [382], 'induced),': [383], 'pharmacological': [385, 465, 476], 'stimuli.': [386, 434, 684], 'Relative': [387], 'blood': [391, 1479, 1644, 2152, 2315, 3102, 3515, 3781, 3803], 'flow': [392, 603, 1645, 2056, 3516, 3782], 'over': [393, 426], 'large': [394], 'areas': [395], 'can': [398, 416, 439, 550, 606, 731, 1020], 'measured': [400, 724, 988, 2317], 'using': [401, 488, 1094, 1120, 2661, 2762, 3140, 3386], 'laser-Doppler': [402, 414, 424, 540, 602, 692], 'imagery': [403], 'spatial': [407], 'distribution': [408, 2006], 'reactivity': [411, 625, 681, 3579], '(20).': [412], 'Alternatively,': [413], 'flowmetry': [415, 693, 2683, 3924], 'measure': [420], 'dynamic': [421], 'flux': [425], 'small': [428, 504, 527, 543, 2060], 'area': [429, 485, 529], 'vasoreactive': [433, 1196], 'Cutaneous': [435, 2453, 2894, 3285, 3706], 'vasodilation': [436, 712, 729, 992, 1018, 1057, 1132, 1680, 1745, 1949, 2009, 2393, 3229, 3354, 3608, 3942], 'or': [437, 470, 746, 1737, 1772], 'vasoconstriction': [438, 850, 1134, 2426], 'elicited': [441], 'through': [442, 508], 'postocclusive': [443], 'reactive': [444, 2238, 2532, 3501], 'hyperemia': [445, 570, 1446, 3502], '(35),': [446], 'whole': [447, 451, 695], 'body': [448, 452, 696], 'heating': [449, 455, 1448, 1649], '(14),': [450], 'cooling,': [453], 'local': [454, 457, 615, 1953, 2423, 2865], '(18),': [456], 'cooling': [458], '(32),': [459], 'application': [462, 699], 'specific': [463], 'vasoactive': [464], 'agents': [466, 477], 'by': [467, 639, 734, 1326, 1506, 1822, 2318, 2394, 3232, 3537, 4001], 'iontophoresis': [468], '(1)': [469], 'intradermal': [471, 560, 688], 'microdialysis.': [472, 587], 'Iontophoresis': [473], 'delivers': [474], 'charged': [475], 'vehicle': [480], 'solution': [481], 'localized': [484, 528, 698, 996], 'opposing': [489], 'electrical': [490, 568], 'current.': [491], 'Intradermal': [492], 'microdialysis': [493, 557, 561, 689, 3143], 'technique': [498], 'permits': [500], 'bidirectional': [502], 'exchange': [503], 'molecular': [505, 544], 'weight': [506, 545], 'substances': [507, 546], 'porous': [510], 'cellulose': [511], 'membrane.': [512], 'Microdialysis': [513], 'offers': [514], 'advantages': [516], 'continuous': [518], 'drug': [519, 538], '(or': [520], 'combination': [521], 'drugs)': [523], 'delivery': [524], 'while': [532, 3926], 'measuring': [533], 'effects': [535, 566, 1313], 'via': [539, 1135], 'flowmetry.': [541], 'interstitium': [549], 'sampled': [552], 'analyzed': [554], 'from': [555, 862], 'effluent.': [558], 'With': [559, 777, 2897, 3440], 'there': [562], 'no': [564], 'confounding': [565], 'current-induced': [569], 'occur': [573], 'iontophoresis,': [575], 'potential': [578], 'confound': [579], 'needle': [581], 'insertion': [582], 'trauma': [583], 'does': [584, 971, 2528], 'exist': [585], 'In': [588, 831, 1292], 'addition': [589], 'these': [591, 632, 645, 853, 1076, 1088], 'techniques,': [592], 'digital': [593], 'power': [594], 'spectral': [595], 'analysis': [596, 2309, 3779, 3929], 'frequency': [598], 'domains': [599], 'meter': [604], 'signal': [605], 'performed': [608], 'partition': [610], 'endothelial,': [613, 1162], 'myogenic,': [614], 'sympathetic': [616], 'activity,': [617], 'hemodynamic,': [618], 'respiratory': [620], 'influences': [621], 'on': [622, 674, 1571, 2496, 2588, 2782, 2882, 3119, 3513, 3577, 3718, 3748, 3814, 3849], '(29).': [626], '[For': [627], 'detailed': [629], 'review': [630, 638], 'methods': [633], 'refer': [634], 'Cracowski': [640, 1443, 1522], 'et': [641], 'al.': [642], '(7).]': [643], 'Collectively,': [644], 'approaches': [648], 'allow': [649], 'targeted': [651], 'manipulation': [652], 'putative': [655, 1245], 'pathways': [657, 708, 795, 1247], 'humans.Our': [664], 'laboratory': [665], 'examined': [667], 'age-associated': [668], 'deficits': [669], 'thermoregulatory': [671, 1572], 'focusing': [673], 'We': [685, 1050], 'have': [686, 903, 987, 1036, 3060, 4018], 'paired': [690], 'during': [694, 1058, 1952, 3383], 'and/or': [697, 1133], 'heat': [701, 1569], 'cold': [703], 'pharmacodissect': [705], 'involved': [709], 'vasoconstriction.': [714, 799], 'Consistent': [715], 'animal': [717, 1032], 'vitro': [720], 'studies,': [722], 'we': [723, 984, 1014], 'decrease': [726, 3549], 'NO-dependent': [728, 1017, 1055, 3607], 'either': [735], '1)': [736], 'inhibiting': [737], 'arginase,': [738], 'which': [739], 'competes': [740], 'common': [743], 'NO': [744, 765], 'substrate,': [745], '2)': [747], 'high-dose': [749], 'ascorbate': [750, 1672, 1734], 'supplementation.': [751], 'results': [753, 861], 'provided': [754], 'contributing': [760], 'age-related': [762], 'impairments': [763], 'bioavailability,': [766], 'implicating': [767], 'upregulated': [768, 1042, 1066], 'arginase': [769, 1040, 1059, 1063, 1610, 1704, 1740, 1773], 'activity': [770, 802, 1613, 1705, 2398], '(14)': 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'redundant,': [1140], 'i.e.,': [1142], 'they': [1143, 1153, 1203], 'do': [1144, 3884], 'specifically': [1146], 'isolate': [1147], 'individual': [1148], 'pathways.': [1151], 'Instead': [1152], 'elicit': [1154], 'integrated': [1156], 'involving': [1160], 'neural,': [1161], 'smooth': [1165], 'contributions.': [1167], 'complex': [1169], 'interactions': [1170], 'nature': [1176], 'integrative': [1181, 1255], 'physiology,': [1182], 'regardless': [1183], 'being': [1188], 'studied.': [1189], 'Because': [1190], 'available': [1192, 1241], 'illicit': [1195], 'responses': [1197, 1303, 1573, 1855, 2236, 2455, 3187, 3873], 'involve': [1199], 'pathways,': [1202], 'provide': [1204], 'global': [1206], 'assessment': [1207, 1224, 1534, 2688], 'function.In': [1210], 'summary,': [1211], 'pharmacodissection': [1226], 'There': [1232], 'invasive,': [1238], 'manipulate': [1243], 'test': [1254], 'function.': [1258], 'More': [1259], 'research': [1260, 1294], 'correlating': [1261], 'pathology-induced': [1262], 'other': [1272, 2555], '(coronary': [1275], 'renal)': [1277], 'needed': [1279, 1308], 'fully': [1281, 1310], 'understand': [1282, 1311], 'implication': [1284], 'pathophysiological': [1286], 'states.': [1291], 'addition,': [1293], 'basic': [1297], 'control': [1300], 'healthy': [1305, 3731], 'populations': [1306], 'pathology.FOOTNOTESThe': [1315], 'costs': [1316], 'publication': [1318], 'this': [1320, 1350], 'article': [1321, 1333], 'were': [1322], 'defrayed': [1323], 'part': [1325], 'payment': [1328], 'page': [1330], 'charges.': [1331], 'The': [1332, 2148, 2769], 'must': [1334], 'therefore': [1335], 'hereby': [1337], 'marked': [1338], '“advertisement”': [1339], 'accordance': [1341], '18': [1343], 'U.S.C.': [1344], 'Section': [1345], '1734': [1346], 'solely': [1347], 'indicate': [1349], 'fact.REFERENCES1': [1351], 'Abahji': [1352], 'TN,': [1353], 'Nill': [1354], 'L,': [1355, 1438, 2384], 'Ide': [1356], 'N,': [1357, 1390, 2226], 'Keller': [1358], 'C,': [1359, 1440, 1591, 1597, 1603, 2031, 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3325, 3410, 3447, 3489, 3596, 3639, 3681, 3753, 3773, 3801, 3824, 3864, 3907, 3976, 4038], 'ISI': [1379, 1411, 1464, 1492, 1518, 1551, 1586, 1663, 1694, 1723, 1760, 1791, 1839, 1873, 1900, 1928, 1962, 1995, 2024, 2074, 2111, 2134, 2173, 2213, 2260, 2298, 2332, 2375, 2409, 2443, 2474, 2512, 2546], 'Google': [1381, 1413, 1466, 1494, 1520, 1553, 1588, 1624, 1665, 1696, 1725, 1762, 1793, 1841, 1875, 1902, 1930, 1964, 1997, 2026, 2076, 2113, 2136, 2175, 2215, 2262, 2300, 2334, 2377, 2411, 2445, 2476, 2514, 2548], 'Scholar2': [1382], 'Abularrage': [1383], 'CJ,': [1384], 'Sidawy': [1385], 'AN,': [1386], 'Aidinian': [1387], 'G,': [1388, 1497, 1880, 2040, 2485], 'Singh': [1389], 'Weiswasser': [1391], 'JM,': [1392, 2000], 'Arora': [1393], 'Evaluation': [1395, 3536], 'microcirculation': [1398, 1914, 2120, 2603, 2669, 3139, 3181, 3333, 3833], 'J': [1402, 1656, 1685, 1715, 1751, 1783, 1830, 1955, 1987, 2017, 2066, 2205, 2290, 2366, 2434, 2464, 2539], 'Vasc': [1403, 1865], 'Surg': [1404], '42:': [1405], '574–581,': [1406], '2005.Crossref': [1407, 1460, 1582, 2510], 'PubMed': [1409, 1462, 1490, 1516, 1549, 1584, 1661, 1721, 1789, 1837, 1871, 1898, 1926, 1993, 2072, 2109, 2132, 2171, 2211, 2258, 2330, 2407], 'Scholar3': [1414], 'American': [1415, 1424, 2740, 3006, 3044, 3267, 3490, 3640, 3908, 3977, 4039], 'Heart': [1416, 1418, 1425, 1655, 1687, 1753, 2368, 2436, 2507, 3317], 'Association.': [1417], 'Disease': [1419, 3133, 3749], 'Stroke': [1421], 'Statistics—2006': [1422], 'Update.': [1423], 'Association,': [1426], '2006.Google': [1427], 'Scholar4': [1428], 'Boignard': [1429], 'A,': [1430, 1558, 1560, 1593, 2002, 2141, 2224, 2271, 2303, 2339, 2382, 2386], 'Salvat-Melis': [1431, 1526], 'M,': [1432, 1527, 1601, 1635, 2037, 2042, 2046, 2092, 2094, 2116, 2139, 2228, 2305], 'Carpentier': [1433], 'PH,': [1434], 'Minson': [1435, 1524, 1636, 1932, 2522], 'CT,': [1436, 1525, 1637, 1933], 'Grange': [1437], 'Duc': [1439], 'Sarrot-Reynauld': [1441], 'F,': [1442, 1844, 2050, 2143, 2145, 2343], 'JL.': [1444], 'Local': [1445, 1671], 'secondary': [1452], "Raynaud's": [1453], 'phenomenon.': [1454], 'Arthritis': [1455], 'Ther': [1457], '7:': [1458], 'R1103–R1112,': [1459], 'Scholar5': [1467], 'Carberry': [1468], 'PA,': [1469, 1848], 'Shepherd': [1470], 'AM,': [1471], 'Johnson': [1472], 'JM.': [1473], 'Resting': [1474], 'maximal': [1476], 'flows': [1480], 'Hypertension': [1485, 2967, 3999], '20:': [1486], '349–355,': [1487], '1992.Crossref': [1488], 'Scholar6': [1495], 'Cohuet': [1496], 'Struijker-Boudier': [1498, 1883], 'H.': [1499], 'Mechanisms': [1500], 'target': [1502, 1890, 1980], 'damage': [1504, 1982], 'caused': [1505], 'hypertension:': [1507, 1887], 'potential.': [1509], 'Pharmacol': [1510, 1543], 'Therap': [1511], '111:': [1512], '81–98,': [1513], '2006.Crossref': [1514, 1547, 1659, 1787, 1924, 2169], 'Scholar7': [1521], 'JL,': [1523], 'Halliwill': [1528], 'JR.': [1529], 'Methodological': [1530], 'issues': [1531], 'humans.': [1541, 1683, 1714, 2462], 'Trends': [1542], 'Sci': [1544, 1619, 2252], '27:': [1545, 1657], '503–508,': [1546], 'Scholar8': [1554], 'Cui': [1555], 'J,': [1556, 2337], 'Arbab-Zadeh': [1557], 'Prasad': [1559], 'Durand': [1561], 'S,': [1562, 2345, 2380], 'Levine': [1563], 'BD,': [1564], 'Crandall': [1565], 'CG.': [1566], 'Effects': [1567, 2492, 3848], 'congestive': [1575], 'patients.': [1578, 2065], 'Circulation': [1579, 1893, 2104, 2402], '112:': [1580], '2286–2292,': [1581], 'Scholar9': [1589], 'Demougeot': [1590], 'Prigent-Tessier': [1592], 'Bagnost': [1594], 'T,': [1595, 2489], 'Andre': [1596], 'Guillaume': [1598], 'Y,': [1599], 'Bouhaddi': [1600], 'Marie': [1602], 'Berthelot': [1604], 'Time': [1606], 'course': [1607], 'expression': [1611], 'spontaneously': [1615], 'rats.': [1617], 'Life': [1618], '80:': [1620], '1128–1134,': [1621], '2006.ISI': [1622], 'Scholar10': [1625], 'Green': [1626], 'DJ,': [1627], 'Maiorana': [1628], 'AJ,': [1629], 'Siong': [1630], 'JH,': [1631], 'Burke': [1632], 'V,': [1633], 'Erickson': [1634], 'Bilsborough': [1638], 'W,': [1639], "O'Driscoll": [1640], 'G.': [1641, 2147, 2731, 3255, 3620, 3954], 'environmental': [1648], 'chronic': [1651, 2362], 'failure.': [1653, 2364], 'Eur': [1654, 1829], '338–343,': [1658], 'Scholar11': [1666], 'Holowatz': [1667, 1698, 1727, 1764, 1934, 2415, 2449, 2520], 'LA,': [1668, 1699, 1728, 1765, 1935, 2265, 2416, 2450, 2521], 'Kenney': [1669, 1700, 1731, 1768, 1938, 2003, 2419, 2451], 'WL.': [1670, 1701, 1732, 1769, 2004, 2420, 2452], 'administration': [1673], 'augments': [1674, 1742, 1775, 2864, 3604], 'NO-': [1675], 'non-NO-dependent': [1677], 'reflex': [1678, 1709, 1743, 1776], 'Am': [1684, 1750, 2289, 2365, 2433, 2463], 'Physiol': [1686, 1689, 1716, 1752, 1755, 1784, 1957, 2019, 2291, 2367, 2370, 2435, 2438, 2465, 2469, 2541], 'Circ': [1688, 1754, 2369, 2437], '293:': [1690, 2439], 'H1090–H1096,': [1691], '2007.Link': [1692, 2441], 'Scholar12': [1697], 'Up-regulation': [1702], 'contributes': [1706, 2802], 'vasodilatation': [1711, 1778, 2501], '581:': [1717], '863–872,': [1718], 'Scholar13': [1726], 'Thompson': [1729, 1766, 2447], 'CS,': [1730, 1767, 2414, 2448], 'supplementation': [1735, 1771], 'alone': [1736], 'combined': [1738], 'inhibition': [1741, 1774, 2527], 'skin.': [1749, 1782, 1828, 2016, 2432], '291:': [1756], 'H2965–H2970,': [1757], '2006.Link': [1758, 2296], 'Scholar14': [1763], 'L-Arginine': [1770], '574:': [1785], '573–581,': [1786], 'Scholar14a': [1794], 'Izjerman': [1795], 'RG,': [1796], 'de': [1797, 1806], 'Jongh': [1798], 'RT,': [1799], 'Beijk': [1800], 'MA,': [1801], 'van': [1802], 'Weissenbruch': [1803], 'MM,': [1804], 'Delemarre-van': [1805], 'Waal': [1807], 'HA,': [1808], 'Serne': [1809], 'EH,': [1810], 'Stehouwer': [1811], 'CD.': [1812], 'Individuals': [1813], 'at': [1814, 2604, 3320], 'risk': [1819], 'characterized': [1821], 'Clin': [1831, 2251], 'Invest': [1832], '33:': [1833], '536–542,': [1834], '2003.Crossref': [1835, 2070, 2107], 'Scholar15': [1842], 'Khan': [1843], 'Litchfield': [1845], 'SJ,': [1846], 'Stonebridge': [1847], 'Belch': [1849], 'JJ.': [1850], 'Lipid-lowering': [1851], 'patients': [1857, 2191, 2360, 2503, 2650, 2758, 3581], 'hypercholesterolaemia': [1859], 'arterial': [1862, 2123, 2676, 2854], 'obstructive': [1863], '4:': [1867], '233–238,': [1868], '1999.Crossref': [1869, 2328], 'Scholar16': [1876], 'Levy': [1877], 'BI,': [1878], 'Ambrosio': [1879], 'Pries': [1881], 'AR,': [1882], 'HA.': [1884], 'Microcirculation': [1885, 3707], 'treatment?': [1892], '104:': [1894], '735–740,': [1895], '2001.Crossref': [1896, 1991], 'Scholar17': [1903], 'Lindstedt': [1904], 'IH,': [1905], 'Edvinsson': [1906, 1908], 'ML,': [1907, 2035, 2090], 'L.': [1909, 2557, 2823, 3665, 3670, 3673, 3677, 3894], 'Reduced': [1910], 'hypertension—a': [1917], 'pilot': [1918], 'study.': [1919], 'Blood': [1920, 3310, 3693, 4010], 'Pressure': [1921], '15:': [1922], '275–280,': [1923], 'Scholar18': [1931], 'Wong': [1936, 2516], 'BJ,': [1937, 2517], 'WL,': [1939], 'Wilkins': [1940, 2268, 2518], 'BW.': [1941], 'Decreased': [1942], 'oxide-': [1944], 'axon': [1946], 'reflex-mediated': [1947], 'age': [1951, 2850], 'heating.': [1954], 'Appl': [1956, 2018, 2540], '93:': [1958], '1644–1649,': [1959], '2002.Link': [1960], 'Scholar19': [1965], 'Park': [1966], 'JB,': [1967], 'Schiffrin': [1968], 'EL.': [1969], 'Small': [1970], 'most': [1975], 'prevalent': [1976], '(earliest?)': [1977], 'form': [1978], 'mild': [1984, 3557], 'Hypertens': [1988, 2067], '19:': [1989], '921–930,': [1990], 'Scholar20': [1998], 'Pierzga': [1999], 'Frymoyer': [2001], 'Delayed': [2005], 'active': [2008, 4015], 'altered': [2011, 3023], 'conductance': [2013], '94:': [2020], '1045–1053,': [2021], '2003.Link': [2022, 2544], 'Scholar22': [2027], 'Rizzoni': [2028, 2078], 'D,': [2029, 2044, 2079, 2220, 2341, 2479], 'Palombo': [2030], 'Porteri': [2032, 2080], 'E,': [2033, 2081], 'Muiesan': [2034, 2089], 'Kozakova': [2036], 'La': [2038], 'Canna': [2039], 'Nardi': [2041], 'Guelfi': [2043], 'Salvetti': [2045, 2387], 'Morizzo': [2047], 'Vittone': [2049], 'Rosei': [2051], 'EA.': [2052], 'Relationships': [2053], 'between': [2054], 'vasodilator': [2057, 2188], 'remodelling': [2062], '21:': [2068], '625–631,': [2069], 'Scholar23': [2077], 'Boari': [2082], 'GE,': [2083], 'De': [2084], 'Ciuceis': [2085], 'Sleiman': [2087], 'I,': [2088], 'Castellano': [2091], 'Miclini': [2093], 'Agabiti-Rosei': [2095], 'E.': [2096, 2820, 2989, 3662], 'Prognostic': [2097], 'significance': [2098], 'small-artery': [2100], 'structure': [2101, 2754], '108:': [2105], '2230–2235,': [2106], 'Scholar24': [2114], 'Rossi': [2115, 2138], 'Carpi': [2117, 2140], 'Skin': [2119, 3459, 3995], 'obliterative': [2124], 'Biomed': [2126, 2165, 2324], 'Pharmacother': [2127, 2166], '58:': [2128], '427–431,': [2129], '2004.Crossref': [2130], 'Scholar25': [2137], 'Galetta': [2142], 'Franzoni': [2144], 'Santoro': [2146], 'investigation': [2149], 'flowmotion:': [2153], 'approach': [2156], 'study': [2158, 2246], 'impairment': [2161], 'diseases?': [2164], '60:': [2167], '437–442,': [2168], 'Scholar26': [2176], 'Sax': [2177], 'FL,': [2178], 'Cannon': [2179], 'RO,': [2180], '3rd': [2181], 'Hanson': [2182], 'Epstein': [2184], 'SE.': [2185], 'angina.': [2194, 2506], 'Evidence': [2195], 'disorder': [2199], 'function?': [2202], 'N': [2203], 'Engl': [2204], '317:': [2207], '1366–1370,': [2208], '1987.Crossref': [2209], 'Scholar27': [2216], 'Shamim-Uzzaman': [2217], 'QA,': [2218], 'Pfenninger': [2219], 'Kehrer': [2221], 'Chakrabarti': [2223], 'Kacirotti': [2225], 'Rubenfire': [2227], 'Brook': [2229], 'R,': [2230, 2347], 'Rajagopalan': [2231], 'Altered': [2233], 'hyperaemia': [2239, 2863], 'disease:': [2243, 3589], 'comparative': [2245], 'vessel': [2249], 'responses.': [2250], '(Lond)': [2253], '103:': [2254], '267–273,': [2255], '2002.Crossref': [2256], 'Scholar28': [2263], 'Sokolnicki': [2264], 'Roberts': [2266], 'SK,': [2267], 'BW,': [2269, 2519], 'Basu': [2270], 'Charkoudian': [2272], 'Contribution': [2274], 'dilation': [2281, 2811], 'individuals': [2283], 'type': [2285, 3583], '2': [2286, 2584, 3115, 3584], 'mellitus.': [2288], 'Endocrinol': [2292], 'Metab': [2293], '292:': [2294], 'E314–E318,': [2295], 'Scholar29': [2301], 'Stefanovska': [2302], 'Bracic': [2304], 'Kvernmo': [2306], 'HD.': [2307], 'Wavelet': [2308, 4007], 'oscillations': [2311], 'laser': [2319, 2681, 2952, 3538, 3922], 'Doppler': [2320, 2682, 3539, 3923, 4003], 'technique.': [2321], 'IEEE': [2322], 'Trans': [2323], 'Eng': [2325], '46:': [2326], '1230–1239,': [2327], 'Scholar30': [2335], 'Stewart': [2336], 'Kohen': [2338], 'Brouder': [2340], 'Rahim': [2342], 'Adler': [2344], 'Garrick': [2346], 'Goligorsky': [2348], 'MS.': [2349], 'Noninvasive': [2350], 'interrogation': [2351], 'microvasculature': [2353, 2845], 'signs': [2355], '287:': [2371], 'H2687–E2696,': [2372], '2004.Link': [2373], 'Scholar31': [2378], 'Taddei': [2379], 'Virdis': [2381], 'Ghiadoni': [2383], 'Magagna': [2385], 'Vitamin': [2389], 'C': [2390, 2495], 'improves': [2391], 'restoring': [2395], '97:': [2403], '2222–2229,': [2404], '1998.Crossref': [2405], 'Scholar32': [2412], 'Thompson-Torgerson': [2413], 'Flavahan': [2417], 'NA,': [2418], 'Rho': [2421], 'kinase-mediated': [2422], 'cold-induced': [2424], 'H30–H36,': [2440], 'Scholar33': [2446], 'norepinephrine': [2457], 'older': [2461, 3554, 4016], 'Regul': [2466], 'Integr': [2467], 'Comp': [2468], '288:': [2470], 'R1108–R1113,': [2471], '2005.Link': [2472], 'Scholar34': [2477], 'Tousoulis': [2478], 'Xenakis': [2480], 'Tentolouris': [2482], 'Davies': [2484], 'Antoniades': [2486], 'Crake': [2488], 'Stefanadis': [2490], 'C.': [2491, 2992, 3252, 3479, 3659, 3960], 'vitamin': [2494, 2714], 'intracoronary': [2497], 'L-arginine': [2498], 'dependent': [2499], 'stable': [2505], '91:': [2508], '1319–1323,': [2509], 'Scholar35': [2515], 'CT.': [2523], 'Nitric': [2524, 3351], 'synthase': [2526], 'alter': [2530], 'hyperemic': [2533], 'circulation.': [2538], '95:': [2542], '504–510,': [2543], 'ScholarAUTHOR': [2549], 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3155, 3175, 3201, 3224, 3274, 3304, 3329, 3345, 3372, 3391, 3413, 3426, 3453, 3471, 3497, 3523, 3546, 3571, 3598, 3647, 3686, 3724, 3737, 3758, 3775, 3807, 3828, 3842, 3868, 3878, 3915, 3935, 3984], '145Young': [2615], 'South': [2616], 'Asian': [2617], 'women': [2618, 2813], 'Kingdom': [2622], 'show': [2623], 'evidence': [2624], 'blunted': [2626, 2978], 'dilatation:': [2628], 'implications': [2629], 'disease18': [2633], 'August': [2634, 2737, 2766, 2832, 3323, 3445, 3905], '2022': [2635, 2738, 2767, 2833, 2870, 2906, 2922, 3004, 3042, 3070, 3099], 'Journal': [2637, 2702, 2741, 2770, 2835, 3007, 3045, 3197, 3268, 3491, 3641, 3682, 3754, 3909, 3978, 4040], 'Hypertension,': [2639, 3200], '40,': [2641], 'No.': [2642, 2749, 2775, 2799, 2841, 2861, 2876, 2971, 3015, 3053, 3076, 3108, 3157, 3177, 3226, 3276, 3306, 3347, 3415, 3455, 3499, 3525, 3573, 3600, 3649, 3688, 3739, 3777, 3809, 3830, 3844, 3917, 3986], '12Evaluation': [2643], 'skeletal': [2645], 'perfusion': [2647, 3540], 'before': 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