Publication Information

{'id': 'https://openalex.org/W2126107341', 'doi': 'https://doi.org/10.1677/erc-08-0175', 'title': 'Novel mechanism of IGF-binding protein-3 action on prostate cancer cells: inhibition of proliferation, adhesion, and motility', 'display_name': 'Novel mechanism of IGF-binding protein-3 action on prostate cancer cells: inhibition of proliferation, adhesion, and motility', 'publication_year': 2009, 'publication_date': '2009-06-10', 'ids': {'openalex': 'https://openalex.org/W2126107341', 'doi': 'https://doi.org/10.1677/erc-08-0175', 'mag': '2126107341', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19509068'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1677/erc-08-0175', 'pdf_url': 'https://erc.bioscientifica.com/downloadpdf/journals/erc/16/3/795.pdf', 'source': {'id': 'https://openalex.org/S193349529', 'display_name': 'Endocrine Related Cancer', 'issn_l': '1351-0088', 'issn': ['1351-0088', '1479-6821'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319937', 'host_organization_name': 'Bioscientifica', 'host_organization_lineage': ['https://openalex.org/P4310319937'], 'host_organization_lineage_names': ['Bioscientifica'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://erc.bioscientifica.com/downloadpdf/journals/erc/16/3/795.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5033854052', 'display_name': 'Petra Massoner', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I143397708', 'display_name': 'Innsbruck Medical University', 'ror': 'https://ror.org/03pt86f80', 'country_code': 'AT', 'type': 'education', 'lineage': ['https://openalex.org/I143397708']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Petra Massoner', 'raw_affiliation_strings': ['Department of Urology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria', 'institution_ids': ['https://openalex.org/I143397708']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062888959', 'display_name': 'Daniela Colleselli', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I143397708', 'display_name': 'Innsbruck Medical University', 'ror': 'https://ror.org/03pt86f80', 'country_code': 'AT', 'type': 'education', 'lineage': ['https://openalex.org/I143397708']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Daniela Colleselli', 'raw_affiliation_strings': ['Department of Urology, Innsbruck Medical University, Anichstraße 35, 6020 Innsbruck, Austria'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, Innsbruck Medical University, Anichstraße 35, 6020 Innsbruck, Austria', 'institution_ids': ['https://openalex.org/I143397708']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052717521', 'display_name': 'Andrea Matscheski', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I138211613', 'display_name': 'Austrian Academy of Sciences', 'ror': 'https://ror.org/03anc3s24', 'country_code': 'AT', 'type': 'government', 'lineage': ['https://openalex.org/I138211613']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Andrea Matscheski', 'raw_affiliation_strings': ['Institute for Biomedical Aging Research, Austrian Academy of Sciences, Rennweg 10, 6020 Innsbruck, Austria'], 'affiliations': [{'raw_affiliation_string': 'Institute for Biomedical Aging Research, Austrian Academy of Sciences, Rennweg 10, 6020 Innsbruck, Austria', 'institution_ids': ['https://openalex.org/I138211613']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034424692', 'display_name': 'Haymo Pircher', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I138211613', 'display_name': 'Austrian Academy of Sciences', 'ror': 'https://ror.org/03anc3s24', 'country_code': 'AT', 'type': 'government', 'lineage': ['https://openalex.org/I138211613']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Haymo Pircher', 'raw_affiliation_strings': ['Institute for Biomedical Aging Research, Austrian Academy of Sciences, Rennweg 10, 6020 Innsbruck, Austria'], 'affiliations': [{'raw_affiliation_string': 'Institute for Biomedical Aging Research, Austrian Academy of Sciences, Rennweg 10, 6020 Innsbruck, Austria', 'institution_ids': ['https://openalex.org/I138211613']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069887691', 'display_name': 'Stephan Geley', 'orcid': 'https://orcid.org/0000-0002-3169-5322'}, 'institutions': [{'id': 'https://openalex.org/I143397708', 'display_name': 'Innsbruck Medical University', 'ror': 'https://ror.org/03pt86f80', 'country_code': 'AT', 'type': 'education', 'lineage': ['https://openalex.org/I143397708']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Stephan Geley', 'raw_affiliation_strings': ['Department of Molecular Pathophysiology of the Biocenter, Innsbruck Medical University, Fritz-Pregl Straße 3, 6020 Innsbruck, Austria'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Pathophysiology of the Biocenter, Innsbruck Medical University, Fritz-Pregl Straße 3, 6020 Innsbruck, Austria', 'institution_ids': ['https://openalex.org/I143397708']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076215352', 'display_name': 'Pidder Jansen‐Dürr', 'orcid': 'https://orcid.org/0000-0001-7771-3429'}, 'institutions': [{'id': 'https://openalex.org/I143397708', 'display_name': 'Innsbruck Medical University', 'ror': 'https://ror.org/03pt86f80', 'country_code': 'AT', 'type': 'education', 'lineage': ['https://openalex.org/I143397708']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Pidder Jansen Dürr', 'raw_affiliation_strings': ['Department of Urology, Innsbruck Medical University, Anichstraße 35, 6020 Innsbruck, Austria'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, Innsbruck Medical University, Anichstraße 35, 6020 Innsbruck, Austria', 'institution_ids': ['https://openalex.org/I143397708']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5008951210', 'display_name': 'Helmut Klocker', 'orcid': 'https://orcid.org/0000-0001-7732-9443'}, 'institutions': [{'id': 'https://openalex.org/I143397708', 'display_name': 'Innsbruck Medical University', 'ror': 'https://ror.org/03pt86f80', 'country_code': 'AT', 'type': 'education', 'lineage': ['https://openalex.org/I143397708']}], 'countries': ['AT'], 'is_corresponding': True, 'raw_author_name': 'Helmut Klocker', 'raw_affiliation_strings': ['Department of Urology, Innsbruck Medical University, Anichstraße 35, 6020 Innsbruck, Austria'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, Innsbruck Medical University, Anichstraße 35, 6020 Innsbruck, Austria', 'institution_ids': ['https://openalex.org/I143397708']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5008951210'], 'corresponding_institution_ids': ['https://openalex.org/I143397708'], 'apc_list': None, 'apc_paid': None, 'fwci': 3.45, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 39, 'citation_normalized_percentile': {'value': 0.827108, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '16', 'issue': '3', 'first_page': '795', 'last_page': '808'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10748', 'display_name': 'Growth Hormone and Insulin-like Growth Factors', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10748', 'display_name': 'Growth Hormone and Insulin-like Growth Factors', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9965, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11339', 'display_name': 'Metabolism, Diabetes, and Cancer', 'score': 0.9906, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/mechanism-of-action', 'display_name': 'Mechanism of Action', 'score': 0.56619185}], 'concepts': [{'id': 'https://openalex.org/C58207958', 'wikidata': 'https://www.wikidata.org/wiki/Q33596', 'display_name': 'Motility', 'level': 2, 'score': 0.725775}, {'id': 'https://openalex.org/C89611455', 'wikidata': 'https://www.wikidata.org/wiki/Q6804646', 'display_name': 'Mechanism (biology)', 'level': 2, 'score': 0.65577275}, {'id': 'https://openalex.org/C84416704', 'wikidata': 'https://www.wikidata.org/wiki/Q188666', 'display_name': 'Adhesion', 'level': 2, 'score': 0.62784004}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.6254897}, {'id': 'https://openalex.org/C2776120743', 'wikidata': 'https://www.wikidata.org/wiki/Q3271540', 'display_name': 'Mechanism of action', 'level': 3, 'score': 0.56619185}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.49336043}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.48941007}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.47469515}, {'id': 'https://openalex.org/C85789140', 'wikidata': 'https://www.wikidata.org/wiki/Q187640', 'display_name': 'Cell adhesion', 'level': 3, 'score': 0.43060818}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.41838267}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.38918602}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.38033745}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.24479663}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.23555613}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.19942492}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.18922186}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.15850031}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.06597322}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C62520636', 'wikidata': 'https://www.wikidata.org/wiki/Q944', 'display_name': 'Quantum mechanics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D018972', 'descriptor_name': 'Insulin-Like Growth Factor Binding Protein 3', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D002448', 'descriptor_name': 'Cell Adhesion', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002448', 'descriptor_name': 'Cell Adhesion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002461', 'descriptor_name': 'Cell Line, Transformed', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004353', 'descriptor_name': 'Drug Evaluation, Preclinical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005109', 'descriptor_name': 'Extracellular Matrix', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005109', 'descriptor_name': 'Extracellular Matrix', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D005109', 'descriptor_name': 'Extracellular Matrix', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018972', 'descriptor_name': 'Insulin-Like Growth Factor Binding Protein 3', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D018972', 'descriptor_name': 'Insulin-Like Growth Factor Binding Protein 3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1677/erc-08-0175', 'pdf_url': 'https://erc.bioscientifica.com/downloadpdf/journals/erc/16/3/795.pdf', 'source': {'id': 'https://openalex.org/S193349529', 'display_name': 'Endocrine Related Cancer', 'issn_l': '1351-0088', 'issn': ['1351-0088', '1479-6821'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319937', 'host_organization_name': 'Bioscientifica', 'host_organization_lineage': ['https://openalex.org/P4310319937'], 'host_organization_lineage_names': ['Bioscientifica'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19509068', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1677/erc-08-0175', 'pdf_url': 'https://erc.bioscientifica.com/downloadpdf/journals/erc/16/3/795.pdf', 'source': {'id': 'https://openalex.org/S193349529', 'display_name': 'Endocrine Related Cancer', 'issn_l': '1351-0088', 'issn': ['1351-0088', '1479-6821'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319937', 'host_organization_name': 'Bioscientifica', 'host_organization_lineage': ['https://openalex.org/P4310319937'], 'host_organization_lineage_names': ['Bioscientifica'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.5, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 59, 'referenced_works': ['https://openalex.org/W1562250847', 'https://openalex.org/W1970101996', 'https://openalex.org/W1972255467', 'https://openalex.org/W1972273837', 'https://openalex.org/W1983987321', 'https://openalex.org/W1986819031', 'https://openalex.org/W1992934249', 'https://openalex.org/W1998893299', 'https://openalex.org/W2003769189', 'https://openalex.org/W2007228548', 'https://openalex.org/W2007244371', 'https://openalex.org/W2015987532', 'https://openalex.org/W2018371450', 'https://openalex.org/W2020368904', 'https://openalex.org/W2021117030', 'https://openalex.org/W2023052773', 'https://openalex.org/W2024410864', 'https://openalex.org/W2026452577', 'https://openalex.org/W2034269086', 'https://openalex.org/W2040604791', 'https://openalex.org/W2046217490', 'https://openalex.org/W2050239312', 'https://openalex.org/W2054156770', 'https://openalex.org/W2061541262', 'https://openalex.org/W2070858088', 'https://openalex.org/W2072514327', 'https://openalex.org/W2076627331', 'https://openalex.org/W2076717151', 'https://openalex.org/W2077515946', 'https://openalex.org/W2077956417', 'https://openalex.org/W2097568177', 'https://openalex.org/W2098419763', 'https://openalex.org/W2101405760', 'https://openalex.org/W2106787323', 'https://openalex.org/W2111715882', 'https://openalex.org/W2111718207', 'https://openalex.org/W2111843196', 'https://openalex.org/W2112558234', 'https://openalex.org/W2134689373', 'https://openalex.org/W2136917807', 'https://openalex.org/W2139241763', 'https://openalex.org/W2140491527', 'https://openalex.org/W2140686252', 'https://openalex.org/W2144678487', 'https://openalex.org/W2156759817', 'https://openalex.org/W2170407972', 'https://openalex.org/W2332998069', 'https://openalex.org/W2398281943', 'https://openalex.org/W261041624', 'https://openalex.org/W292398390', 'https://openalex.org/W4206242032', 'https://openalex.org/W4233132424', 'https://openalex.org/W4233984730', 'https://openalex.org/W4235908535', 'https://openalex.org/W4240385285', 'https://openalex.org/W4241793218', 'https://openalex.org/W4247562473', 'https://openalex.org/W4255483444', 'https://openalex.org/W74141105'], 'related_works': ['https://openalex.org/W2789349812', 'https://openalex.org/W2392388241', 'https://openalex.org/W2352776361', 'https://openalex.org/W2278657244', 'https://openalex.org/W2269305777', 'https://openalex.org/W2061084809', 'https://openalex.org/W1989257177', 'https://openalex.org/W1988655739', 'https://openalex.org/W1965866142', 'https://openalex.org/W1600127933'], 'abstract_inverted_index': {'IGF-binding': [0], 'protein-3': [1], '(IGFBP-3)': [2], 'is': [3], 'a': [4, 105, 193], 'modulator': [5], 'of': [6, 34, 40, 67, 82, 89, 109, 124, 136, 174, 182, 186, 195], 'the': [7, 32, 80, 120], 'IGF-signaling': [8], 'pathway': [9], 'and': [10, 43, 87, 99, 122, 171, 191], 'was': [11, 104, 129, 138, 152], 'described': [12, 180], 'as': [13], 'an': [14, 63], 'anti-cancer': [15], 'agent': [16], 'in': [17, 74, 119, 197], 'prostate': [18, 45, 70, 90, 175], 'cancer.': [19], 'The': [20, 132], 'molecular': [21], 'mechanisms': [22, 181], 'underlying': [23], 'these': [24], 'effects': [25], 'remained,': [26], 'however,': [27], 'largely': [28], 'undefined.': [29], 'We': [30, 77], 'analyzed': [31], 'influence': [33, 81], 'recombinant': [35], 'IGFBP-3': [36, 50, 68, 83, 110, 137, 151, 166, 183, 196], 'on': [37, 69, 84, 111, 140], 'cell': [38, 53, 72, 113, 141, 145, 157], 'proliferation': [39, 54, 58, 73], 'PC3,': [41], 'Du145,': [42], 'LNCaP': [44], 'cancer': [46, 71, 91], 'cells.': [47, 177], 'As': [48], 'expected,': [49], 'inhibited': [51], 'IGF-stimulated': [52], 'by': [55], 'blocking': [56], 'IGF-mediated': [57], 'signals,': [59], 'but': [60], 'we': [61, 163], 'observed': [62], 'IGF-independent': [64], 'inhibitory': [65, 107, 134], 'effect': [66, 108, 135], 'long-term': [75], 'cultures.': [76], 'further': [78], 'investigated': [79], 'adhesion,': [85, 169], 'motility,': [86], 'invasion': [88, 101, 158, 172], 'cells': [92], 'using': [93], 'adhesion': [94, 114, 128], 'assays,': [95], 'live-cell': [96], 'imaging': [97], 'techniques,': [98], 'matrigel': [100], 'measurements.': [102], 'There': [103], 'clear': [106], 'tumor': [112, 156, 176, 189], 'to': [115, 154], 'extracellular': [116], 'matrix': [117], 'components': [118], 'presence': [121], 'absence': [123], 'IGF,': [125], 'whereas': [126], 'cell-cell': [127], 'not': [130], 'affected.': [131], 'same': [133], 'determined': [139], 'motility': [142], 'when': [143], 'real-time': [144], 'movements': [146], 'were': [147], 'followed.': [148], 'In': [149, 161], 'addition,': [150], 'able': [153], 'inhibit': [155], 'through': [159], 'matrigel.': [160], 'summary,': [162], 'show': [164], 'that': [165], 'inhibits': [167], 'proliferation,': [168], 'migration,': [170], 'processes': [173], 'These': [178], 'newly': [179], 'can': [184], 'be': [185], 'importance': [187], 'for': [188], 'progression': [190], 'support': [192], 'role': [194], 'therapeutic': [198], 'settings.': [199]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2126107341', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2025-01-11T20:33:53.312242', 'created_date': '2016-06-24'}