Loss of PECAM-1 Function Impairs Alveolarization

Name: Work Video:
Duration: 3 min 30 s
Horace M. DeLisser; Brian P. Helmke; Gaoyuan Cao; Patricia M. Egan; Darren B. Taichman; Melane Fehrenbach; Aisha Zaman; Zheng Cui; Gopi S. Mohan; H. Scott Baldwin; Peter F. Davies; Rashmin C. Savani
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'examined': [58, 271, 2544, 3144, 3325], 'date': [60, 273], 'have': [61, 274, 1035, 4106, 4488, 4552, 4950, 5273], 'resulted': [62, 275, 2603, 2973], 'endothelial': [64, 75, 176, 277, 288, 389, 840, 850, 857, 861, 924, 984, 1380, 1392, 1998, 2818, 2858, 3694, 3844, 3901, 4188, 4562, 5279, 5315, 5453, 5663], 'cell': [65, 76, 170, 278, 289, 383, 594, 862, 888, 925, 985, 1307, 1461, 1644, 1971, 2027, 2819, 2859, 3655, 3708, 3816, 4270, 4373, 4467, 5075, 5280, 5340, 5578, 5664], '(EC)': [66, 279, 926], 'death.': [67, 280], 'We': [68, 281, 3023, 3427, 3759, 5353, 5704], 'therefore': [69, 282, 1231, 3024, 3715, 4826], 'targeted': [70, 283], 'function': [72, 190, 285, 403, 1337, 2347, 2980, 3830, 3845, 4465, 5176, 5256], 'platelet': [74, 287, 860, 983], 'adhesion': [77, 290, 863, 986], 'molecule,': [78, 291], '(PECAM-1),': [79, 292], 'an': [80, 98, 293, 311, 1248, 1255, 2213, 2467, 2815, 2975, 3261, 3506, 3762, 4434, 5210, 5268], 'EC': [81, 86, 103, 122, 164, 201, 294, 299, 316, 335, 377, 414, 946, 1040, 1260, 1264, 1280, 1301, 1350, 1367, 2008, 2894, 2937, 2956, 2979, 3181, 3532, 3559, 3721, 3767, 3786, 3801, 4093, 4464, 4471, 4482, 5018, 5073, 5083, 5110, 5191, 5361, 5672], 'surface': [82, 295, 529], 'molecule': [83, 296, 987, 5212], 'that': [84, 101, 129, 154, 185, 198, 297, 314, 342, 367, 398, 411, 599, 620, 696, 823, 942, 944, 964, 1037, 1254, 1258, 1332, 1347, 1930, 2009, 2035, 2246, 2263, 2650, 2675, 2893, 2968, 3008, 3124, 3164, 3195, 3292, 3429, 3609, 3625, 3690, 3717, 3761, 3765, 3825, 4059, 4318, 4393, 4462, 4533, 4554, 4776, 4799, 4956, 5066, 5082, 5213, 5271, 5359, 5399, 5460, 5478], 'promotes': [85, 298, 1039, 4266, 5017], 'migration': [87, 171, 300, 384, 1041, 1308, 1492, 2432, 2951, 3673, 3768, 5076], 'has': [89, 302], 'been': [90, 303, 4489, 4951], 'implicated': [91, 304, 3836], 'vivo': [94, 307, 2804, 4743], 'angiogenesis.': [95, 308, 4382], 'Administration': [96, 309], 'anti-PECAM-1': [99, 312, 1107, 1256, 1755, 2525, 3763, 5479], 'antibody': [100, 136, 313, 349, 1108, 1249, 1257, 1449, 1756, 2946, 3293, 3764, 4841, 5480], 'inhibits': [102, 211, 315, 424, 1109, 1259, 3766, 4463, 4842], 'migration,': [104, 317, 1261], 'not': [106, 319, 1263, 2875, 2897, 2955, 2983, 3601, 3711, 3770, 4376, 4812], 'proliferation': [107, 320, 1265, 1645, 1972, 2471, 2957, 3611, 3703, 3771, 4474], 'or': [108, 167, 321, 380, 461, 617, 625, 836, 1117, 1266, 1304, 1666, 1672, 1676, 1747, 1754, 1862, 1950, 2699, 2704, 2958, 3329, 3772, 3804, 4850, 5687], 'survival': [109, 322, 1267, 2473, 2959, 3773, 4185, 4472], 'vitro,': [111, 324, 1269, 5013], 'disrupted': [112, 325], 'normal': [113, 326, 1271, 2552, 2627, 3068, 3111, 3478, 3777], 'alveolar': [114, 327, 462, 528, 580, 816, 957, 1272, 1910, 1920, 2026, 2033, 2523, 2606, 2609, 2624, 2679, 2729, 2747, 2750, 3060, 3172, 3364, 3368, 3420, 3444, 3498, 3654, 3778, 3849, 3975, 4078, 4267, 4371, 5168, 5339, 5577, 5630], 'septation': [115, 328, 525, 704, 1273, 2629, 3309, 3376, 3779], 'neonatal': [117, 330, 1237, 1275, 2533, 3681, 3749, 3781, 4024, 4074], 'rat': [118, 331, 824, 866, 1234, 1276, 1732, 1774, 2055, 2356, 2522, 2534, 3527, 3746, 3782, 4023, 4478, 5476], 'pups': [119, 130, 332, 343, 1238, 1277, 1733, 1775, 2535, 3750, 3783, 5477], 'without': [120, 162, 333, 375, 1278, 1299, 1677, 3530, 3784, 3799, 4469, 4480], 'reducing': [121, 334, 1279, 3785, 4481], 'content.': [123, 336, 1281, 3533, 3560, 3787], 'Three-dimensional': [124, 337, 2200, 2989], 'reconstruction': [125, 338, 3028, 3097], 'lungs': [127, 340, 1324, 2542, 2621, 2755, 3317, 3350, 3540, 3679], 'showed': [128, 341, 1253, 2573, 2622, 3123, 3824], 'treated': [131, 344, 1778, 2701, 2905], 'with': [132, 345, 587, 830, 1106, 1320, 1376, 1551, 1675, 1693, 1750, 1779, 2355, 2582, 2600, 2608, 2640, 2668, 2695, 2702, 2774, 2862, 2868, 2906, 3059, 3342, 3361, 3390, 3454, 3568, 3604, 3689, 3745, 4099, 4426, 5100, 5498, 5574, 5582, 5626, 5680, 5724], 'a': [133, 206, 346, 419, 429, 547, 687, 790, 838, 968, 1200, 1355, 1629, 1788, 1797, 1817, 1851, 1932, 1940, 2039, 2099, 2260, 2436, 2445, 2790, 2908, 3116, 3357, 3483, 3493, 3725, 3732, 3895, 3979, 4070, 4183, 4814, 4964, 5107, 5216, 5335, 5373, 5381, 5583, 5633], 'blocking': [134, 347, 1250], 'PECAM-1': [135, 158, 189, 348, 371, 402, 1038, 1244, 1295, 1336, 2357, 2520, 2887, 3296, 3545, 3557, 3565, 3756, 3795, 3811, 3829, 4558, 5016, 5070, 5105, 5175, 5208, 5255, 5368, 5454], 'had': [137, 350, 2466, 2636, 2657, 2662, 2927, 3107, 5482], 'remodeling': [138, 351, 577, 3184, 3921, 5120], 'more': [140, 353, 3166, 3186, 4830, 5490], 'proximal': [141, 354, 3167, 3187, 3935, 5491], 'branches': [142, 355], 'resulting': [143, 356, 4834, 5170], 'tubular': [146, 359, 3134], 'airways.': [147, 360], 'Subsequent': [148, 361, 1282, 3949], 'studies': [149, 362, 694, 1034, 1283, 1656, 1728, 2327, 3301, 4551, 4949], 'PECAM-1-null': [151, 364, 1197, 1285, 1794, 3322, 3405, 3473, 3511, 3518, 3578, 3648, 3682, 3790, 4486, 4781, 4961, 5349], 'mice': [152, 365, 1198, 1286, 1315, 1402, 3218, 3323, 3345, 3353, 3406, 3451, 3474, 3579, 3668, 3683, 3813, 4487, 4782, 4918, 4962], 'confirmed': [153, 366, 1287, 3082, 3593, 4952], 'absence': [156, 369, 1293, 3563, 3793, 4538], 'impaired': [159, 372, 1296, 3569, 3796, 4370, 4779], 'murine': [160, 373, 1297, 3797, 5072], 'affecting': [163, 376, 1300, 3800, 4470], 'content,': [165, 378, 1302, 3802], 'proliferation,': [166, 379, 1303, 2028, 3803], 'survival.': [168, 381, 1305, 3805], 'Further,': [169, 382, 1192, 2461, 2727, 3460, 3650, 3788], 'was': [172, 385, 1316, 1369, 1457, 1493, 1549, 1600, 1626, 1680, 1973, 2012, 2042, 2064, 2117, 2181, 2257, 2439, 2454, 2672, 2686, 2896, 2939, 3310, 3377, 3548, 3566, 3592, 3606, 3684, 3704, 4026], 'reduced': [173, 386, 1195, 3686, 3815, 4381, 4959], 'cells': [177, 390, 1393, 1595, 1625, 1660, 1982, 1999, 2034, 3627, 3695, 4189], 'isolated': [178, 391, 1312, 1395, 3676, 3913], 'these': [180, 393, 920, 939, 1288, 2464, 2669, 2900, 2965, 3193, 3500, 3810, 3954, 3993, 4424, 4792, 4810, 4947, 5563], 'mice.': [181, 394, 1328, 3314, 3393, 3512, 3741, 4823, 5326], 'These': [182, 395, 1329, 2350, 3161, 3713, 3916, 4085], 'data': [183, 396, 940, 1330, 2278, 2593, 2966, 3162, 3209, 3502, 3714], 'suggest': [184, 397, 941, 1331, 2967, 3716], 'loss': [187, 207, 400, 420, 1334, 1356, 2985, 3555, 3726, 3827, 4365, 4556, 4837, 5068, 5173, 5253, 5366, 5668], 'compromises': [191, 404, 1338, 5188], 'postnatal': [192, 405, 1339, 1730, 3528, 3832], 'provide': [196, 409, 1343, 3503], 'evidence': [197, 410, 1346, 3504, 5398], 'inhibition': [199, 412, 1348, 2976, 3262, 3294, 4019, 4355], 'function,': [202, 415, 1351, 5369], 'contrast': [204, 417, 1353, 4422, 5328], 'viable': [209, 422, 1358, 1624, 2987, 3220, 3728, 4367, 4493], 'EC,': [210, 423, 856], 'alveolarization.': [212, 425, 1246, 1793, 3426, 3758, 5376], 'Lung': [426, 444, 1391, 2323, 2502, 5537], 'represents': [428], 'carefully': [430], 'coordinated': [431], 'air-way': [434], 'morphogenesis': [435], 'concurrent': [437, 3865], 'vascular': [438, 813, 839, 849, 3927, 4083, 4534, 5220, 5499], '(1Burri': [440, 2498], 'P.H.': [441, 2499], 'McDonald': [442, 2500], 'J.A.': [443, 1020, 1074, 1164, 1212, 2501, 3272, 4640, 4697, 4752, 4872, 4976, 5052, 5239], 'Growth': [445, 2503], 'Development.': [447, 2505], 'Marcel': [448, 2506, 5542], 'Dekker,': [449, 2507, 5543], 'Inc.,': [450, 2508, 5544], 'New': [451, 2509, 5545], 'York1997:': [452, 2510], '1035Google': [453, 2511], 'Scholar).': [454, 522, 681, 735, 916, 1032, 1191, 1228, 1487, 1522, 1964, 2430, 2512, 3288, 3888, 4015, 4179, 4352, 4420, 4768, 4943, 5250, 5448, 5548, 5661], 'For': [455, 1602, 1727, 1992, 2022, 2174], 'rodents,': [458, 2485], 'following': [469], '(2Massaro': [497], 'D.': [498, 510, 712, 726, 771, 1068, 1210, 1479, 2832, 2914, 3270, 3870, 4306, 4695, 4750, 4974, 5046, 5146, 5223, 5439], 'Massaro': [499, 511, 711, 725, 2915, 5709], 'G.D.': [500, 512, 710, 724, 2916], 'Am.': [501, 671, 727, 754, 776, 908, 1056, 1093, 1134, 1167, 1213, 1512, 2420, 3273, 3875, 4002, 4048, 4451, 4647, 4698, 4726, 4753, 4875, 4933, 4977, 5034, 5129, 5151, 5651], 'J.': [502, 645, 648, 672, 728, 755, 777, 909, 1057, 1076, 1094, 1135, 1168, 1214, 1469, 1477, 1513, 2367, 2386, 2421, 2822, 2830, 3232, 3237, 3252, 3274, 3876, 4003, 4049, 4196, 4217, 4226, 4249, 4251, 4328, 4337, 4410, 4452, 4505, 4510, 4525, 4638, 4648, 4671, 4699, 4727, 4754, 4876, 4934, 4978, 5035, 5054, 5130, 5152, 5240, 5422, 5531, 5601, 5604, 5652], 'Physiol.': [503, 515, 673, 729, 910, 1058, 1095, 1136, 1514, 2422, 2919, 4050, 4453, 4728, 4935, 5036, 5653], '1986;': [504, 516, 2920], '251:': [505], 'R218-R224PubMed': [506], 'Google': [507, 521, 657, 680, 721, 734, 766, 788, 915, 1003, 1015, 1031, 1065, 1083, 1102, 1143, 1173, 1190, 1227, 1428, 1486, 1521, 1963, 2394, 2429, 2839, 2925, 3257, 3287, 3887, 4014, 4055, 4139, 4161, 4178, 4210, 4240, 4262, 4315, 4351, 4419, 4460, 4530, 4592, 4623, 4659, 4679, 4712, 4735, 4767, 4881, 4898, 4942, 4991, 5043, 5061, 5141, 5163, 5249, 5311, 5432, 5447, 5522, 5613, 5660], 'Scholar,': [508, 658, 722, 767, 1004, 1016, 1066, 1084, 1144, 1174, 4140, 4162, 4211, 4241, 4624, 4713, 4882, 5044, 5142, 5433], '3Massaro': [509], 'Annu.': [513, 2917], 'Rev.': [514, 2918], '58:': [517, 2921], '73-92Crossref': [518, 2922], 'Scopus': [519, 655, 678, 719, 764, 786, 1001, 1013, 1029, 1063, 1081, 1100, 1141, 1188, 1225, 1426, 1519, 1961, 2392, 2427, 2923, 3285, 3885, 4012, 4137, 4159, 4176, 4208, 4238, 4260, 4349, 4417, 4458, 4590, 4621, 4657, 4677, 4710, 4733, 4765, 4896, 4940, 4989, 5041, 5059, 5139, 5161, 5247, 5309, 5430, 5445, 5520, 5611, 5658], '(134)': [520, 2924], 'This': [523, 576, 3591, 5468], 'secondary': [524, 2628, 2643, 2654, 3308, 3375], 'greatly': [526], 'increases': [527], 'area,': [530], 'enabling': [531], 'efficient': [532], 'gas': [533], 'exchange.': [534], 'begin': [537], 'invaginations': [539, 2641], 'saccular': [542, 2638, 3170], 'wall': [543], 'consist': [545], 'core': [548], 'connective': [550], 'tissue': [551, 589, 1529, 1948, 1967, 2204, 3142], 'flanked': [552], 'on': [553, 1761, 1768, 1796, 1816, 1829, 2038, 2212, 2321, 2345, 2469, 2545, 2757, 2843, 2933, 2997, 3017, 3326, 3346, 3582, 4022, 4108, 4916, 5276, 5386, 5484], 'either': [554], 'side': [555], 'capillary': [557, 3891, 3926], 'vessels.': [558], 'In': [559, 1488, 1650, 2597, 3851, 4421, 5012, 5193, 5327, 5570], 'time,': [560], 'there': [561, 3977, 4800, 5396], 'is': [562, 690, 818, 826, 982, 1194, 2492, 3480, 3978, 4182, 4541, 4778, 4958, 5085, 5098, 5209, 5397, 5470, 5565], 'stretching': [563], 'thinning': [565, 2574], 'septae,': [568], 'accompanied': [569], 'fusion': [571, 3950], 'septal': [574, 2580, 3157], 'capillaries.': [575], 'ultimately': [578], 'produces': [579], 'composed': [582], 'endothelia': [584], 'epithelia': [586], 'interstitial': [588], 'interposed': [590], 'between': [591, 3401, 3663, 5345], 'two': [593, 3820, 3862], 'layers.': [595], 'Identifying': [596], 'mechanisms': [598], 'underlie': [600], 'alveolarization': [604, 685, 739, 825, 934, 1361, 2497, 2735, 2912, 2972, 3298, 3400, 3479, 3509, 3529, 3738, 4025, 4357, 4479, 4777, 5122, 5456], 'may': [605, 3730, 4105, 4801, 5177, 5214, 5555, 5678], 'help': [606], 'increase': [608, 3495, 3981], 'our': [609, 2879, 5080, 5387, 5473], 'understanding': [610], 'diseases': [613, 5564], 'such': [614], 'emphysema': [616, 700, 5505, 5572], 'bronchopulmonary': [618, 5525, 5637], 'dysplasia': [619, 5526, 5638], 'are': [621, 951, 2273, 2292, 3219, 4319, 4492, 4811, 4825, 5405, 5501, 5624, 5705], 'characterized': [622, 3481], 'destruction': [624], 'failure': [626], 'alveoli': [630, 3109, 3127, 3491, 3639], '(4Kasahara': [631, 5587], 'Y.': [632, 751, 3999, 4289, 5126, 5588], 'Tuder': [633, 902, 4042, 5589], 'R.M.': [634, 903, 1150, 4043, 4858, 5590], 'Taraseviciene-Stewart': [635, 5591], 'L.': [636, 1475, 2828, 4304, 4397, 5592], 'Le': [637, 895, 4035, 5593], 'Cras': [638, 896, 4036, 5594], 'T.D.': [639, 897, 4037, 5595], 'Abman': [640, 906, 4046, 5596], 'S.': [641, 899, 1070, 4039, 4119, 4131, 4153, 4287, 4582, 4615, 4689, 4691, 5048, 5233, 5301, 5597], 'Hirth': [642, 900, 4040, 4404, 5598], 'P.K.': [643, 5599], 'Waltenberger': [644, 5600], 'Voelkel': [646, 904, 4044, 5602], 'N.F.': [647, 905, 4045, 5603], 'Clin.': [649, 5241, 5605], 'Investig.': [650, 5242, 5606], '2000;': [651, 730, 760, 911, 2388, 4008, 4051, 5135, 5607], '106:': [652, 5608], '1311-1319Crossref': [653, 5609], 'PubMed': [654, 677, 718, 733, 763, 785, 914, 1000, 1012, 1028, 1062, 1080, 1099, 1140, 1187, 1224, 1425, 1518, 1960, 2391, 2426, 3284, 3884, 4011, 4054, 4136, 4158, 4175, 4207, 4237, 4259, 4314, 4348, 4416, 4457, 4589, 4620, 4656, 4676, 4709, 4732, 4764, 4895, 4939, 4988, 5040, 5058, 5138, 5160, 5246, 5308, 5429, 5444, 5519, 5610, 5657], '(967)': [656, 5612], '5Maniscalco': [659], 'W.M.': [660, 1955, 5640], 'Watkins': [661, 5641], 'R.H.': [662, 5642], 'Pryhuber': [663, 5643], 'G.S.': [664, 3222, 4495, 4611, 5644], 'Bhatt': [665, 5645], 'A.': [666, 1053, 1090, 1131, 1206, 1509, 2417, 3239, 3241, 3266, 4132, 4154, 4215, 4247, 4326, 4448, 4512, 4514, 4609, 4636, 4746, 4930, 4970, 5031, 5225, 5231, 5646], 'Shea': [667, 5647], 'C.': [668, 1160, 1180, 2375, 4409, 4568, 4578, 4719, 4868, 4888, 5287, 5297, 5648], 'Huyck': [669, 5649], 'H.': [670, 3226, 3230, 4285, 4403, 4499, 4503, 5420, 5650], '2002;': [674, 1059, 1137, 1422, 1515, 2423, 4311, 4454, 4936, 5037, 5243, 5654], '282:': [675, 1060, 1138, 1516, 2424, 4455, 4937, 5038, 5655], 'L811-L823Crossref': [676, 5656], '(212)': [679, 5659], 'promise': [683], 'therapeutic': [688], 'target': [689], 'seen': [691, 3016], 'demonstrating': [695, 2611], 'retinoic': [697], 'acid': [698], 'reverses': [699], 'rescues': [702], 'failed': [703, 2663], 'relevant': [706], '(6Massaro': [709], 'Nat.': [713, 4254, 4309], 'Med.': [714, 4255, 4310, 4411], '1997;': [715, 782, 1170, 3881, 4172, 4878, 5157], '3:': [716, 1185, 4893], '675-677Crossref': [717], '(509)': [720], '7Massaro': [723], '278:': [731], 'L955-L960Crossref': [732], 'completion': [737], 'must': [740, 4096], 'necessarily': [741], 'involve': [742], 'expansion': [744], 'vasculature': [747, 3855, 3937, 5416, 5554], '(8Schachtner': [748, 3996, 5123], 'S.K.': [749, 3997, 5124], 'Wang': [750, 3998, 5125], 'Baldwin': [752, 4000, 5127], 'H.S.': [753, 4001, 5128], 'Respir.': [756, 778, 3877, 4004, 4649, 5131, 5153], 'Cell': [757, 779, 1023, 1609, 1652, 3702, 3878, 4005, 4650, 5132, 5154], 'Mol.': [758, 780, 3879, 4006, 4651, 5133, 5155], 'Biol.': [759, 781, 996, 1024, 3880, 4007, 4197, 4227, 4338, 4652, 5134, 5156], '22:': [761, 4009, 5136], '157-165Crossref': [762, 4010, 5137], '(133)': [765, 4013, 5140], '9deMello': [768, 5143], 'D.E.': [769, 1006, 3868, 5144], 'Sawyer': [770, 3869, 5145], 'Galvin': [772, 3871, 5147], 'N.': [773, 1018, 3872, 4195, 4225, 4336, 4399, 5148], 'Reid': [774, 3873, 5149], 'L.M.': [775, 3874, 5150], '16:': [783, 3882, 5158], '568-581Crossref': [784, 3883, 5159], '(249)': [787, 3886, 5162], 'Scholar)': [789, 1429, 3258, 4263, 4461, 4736, 4899, 4992, 5312, 5523], 'that,': [792], 'at': [793, 1596, 1697, 1707, 1837, 2015, 2045, 2139, 2217, 3333, 3438, 3461, 3594, 5199, 5317, 5393], 'development,': [798, 2524, 4535], 'angiogenic': [801], 'sprouting': [802], 'new': [804, 2791, 2872, 3944], 'vessels': [805, 2018, 2873, 3065, 3619, 3945, 3995, 4907, 5323], 'preexisting': [807, 3947], 'ones.': [808, 3948], 'importance': [810, 3838, 4091, 5115], 'component': [814], 'demonstrated': [819, 1036, 2736, 3814], 'fact': [822], 'inhibited': [827, 2440, 2947, 3526], 'treatment': [829, 1105, 1789, 2599, 5481, 5581], 'anti-angiogenesis': [831], 'agents': [832], '(e.g.': [833], 'fumagillin,': [834, 4067], 'thalidomide,': [835], 'SU5416,': [837, 4069], 'growth': [841, 851, 1381, 4110, 4271, 4387, 5000], 'factor': [842, 1382, 4186], '(VEGF)': [843], '5The': [844], 'abbreviations': [845], 'used': [846, 3025, 5093], 'are:': [847], 'VEGF,': [848], 'factor;': [852], 'VEGFR,': [853], 'VEGF': [854, 4181, 5584, 5619], 'receptor;': [855], 'cell;': [858], 'PECAM-1,': [859, 2339, 4540], 'molecule;': [864], 'RLMEC,': [865], 'microvascular': [868, 1366], 'EC;': [869], 'H&E,': [870], 'hematoxylin': [871], 'eosin;': [873], 'mAb,': [874], 'monoclonal': [875, 1448, 2335], 'antibody;': [876], 'GAPDH,': [877], 'glyceraldehyde-3-phosphate': [878], 'dehydrogenase;': [879], 'TUNEL,': [880], 'terminal': [881], 'deoxynucleotidyltransferase-mediated': [882], 'dUTP': [883], 'nick': [884], 'end-labeling;': [885], 'PCNA,': [886, 1979], 'proliferating': [887], 'nuclear': [889], 'antigen.': [890], 'receptor': [891, 4388, 5585, 5623], 'antagonist)': [892], '(10Jakkula': [893, 4033], 'M': [894, 4034], 'Gebb': [898, 4038], 'K.P.': [901, 4041], 'S.H.': [907, 4047], '279:': [912, 4052], 'L600-L607Crossref': [913, 4053], 'However,': [917, 2431, 2632, 3119, 3671, 4549, 5377], 'result': [922, 3989, 4379], 'apoptosis,': [927, 1658, 5362, 5579], 'making': [928], 'contribution': [930, 3182], 'ECs': [932, 1311, 1321, 1524, 3613, 3630, 3675, 3808, 4368], 'difficult': [935], 'interpret.': [937], 'Nevertheless,': [938], 'molecules': [943, 963], 'regulate': [945, 5461], 'activity': [947, 2103], 'required': [948, 2096], 'for': [949, 956, 1557, 1614, 1663, 1879, 1901, 1978, 2014, 2019, 2044, 2049, 2450, 2496, 2595, 2754, 3197, 3356, 3734, 4187, 4545, 5710], 'likely': [952], 'be': [954, 975, 2265, 2665, 3204, 3386, 3731, 4097, 4361, 4803, 5178, 5205, 5391, 5557], 'important': [955, 976], 'development.': [958, 3190, 3850, 4084, 4548], 'One': [959], 'endothelial-expressed': [962], 'appears': [965, 5389], 'play': [967, 5215], 'role': [969, 5103, 5217], 'angiogenesis,': [971, 5198], 'thus': [973], 'might': [974, 4360, 5257, 5272, 5370, 5457], '(PECAM-1)': [988], '(11Newman': [989], 'P.J.': [990, 2381, 4584, 4725, 5303], 'Newman': [991, 2380, 4575, 4583, 4722, 4724, 5294, 5302], 'D.K.': [992, 4576, 4723, 5295], 'Arterioscler.': [993], 'Thromb.': [994], 'Vasc.': [995], '2003;': [997, 1009, 1025, 1077, 1216, 3276, 4586, 4756, 4980, 5055, 5305], '23:': [998], '953-964Crossref': [999], '(339)': [1002], '12Jackson': [1005], 'FEBS': [1007], 'Lett.': [1008], '540:': [1010], '7-14Crossref': [1011], '(153)': [1014], '13Ilan': [1017], 'Madri': [1019, 1073, 1163, 1211, 3271, 4696, 4751, 4871, 4975, 5051, 5238], 'Curr.': [1021], 'Opin.': [1022], '15:': [1026], '515-524Crossref': [1027], '(209)': [1030], '(14Cao': [1042, 1120, 1498, 2406, 4437, 4919, 5020], 'G.': [1043, 1121, 1499, 2407, 3247, 4407, 4438, 4520, 4920, 5021], "O'Brien": [1044, 1122, 1500, 2364, 2408, 4439, 4921, 5022], 'C.D.': [1045, 1086, 1123, 1501, 2365, 2409, 4440, 4922, 5023], 'Zhou': [1046, 1124, 1502, 2410, 4441, 4923, 5024], 'Z.': [1047, 1125, 1176, 1503, 2411, 4442, 4884, 4924, 5025], 'Sanders': [1048, 1126, 1504, 2412, 4443, 4925, 5026], 'S.M.': [1049, 1127, 1166, 1505, 2383, 2413, 4444, 4580, 4626, 4874, 4926, 5027, 5299], 'Greenbaum': [1050, 1128, 1506, 2414, 4445, 4927, 5028], 'J.N.': [1051, 1129, 1507, 2415, 4446, 4928, 5029], 'Makrigiannakis': [1052, 1089, 1130, 1508, 2416, 4447, 4929, 5030], 'DeLisser': [1054, 1091, 1132, 1181, 1510, 2418, 4449, 4889, 4931, 5032], 'H.M.': [1055, 1092, 1133, 1146, 1182, 1511, 2385, 2419, 4450, 4854, 4890, 4932, 5033], 'C1181-C1190Crossref': [1061, 1139, 1517, 2425, 4456, 4938, 5039], '(174)': [1064, 1142, 1520, 2428, 4459, 4941, 5042], '15Gratzinger': [1067, 5045], 'Canosa': [1069, 4690, 5047], 'Engelhardt': [1071, 5049, 5236], 'B.': [1072, 3243, 4295, 4516, 5050, 5237], 'FASEB': [1075, 5053], '17:': [1078, 5056], '1458-1469Crossref': [1079, 5057], '(70)': [1082, 5060], "16O'Brien": [1085], 'Cao': [1087], 'G': [1088], '2004;': [1096, 4653, 4673, 5511], '287:': [1097], 'C1103-C1113Crossref': [1098], '(56)': [1101], 'Scholar),': [1103, 2395, 2840, 2926, 4056, 4316, 4531, 4593, 4660, 4680, 5062, 5164, 5614], 'vessel': [1110, 4843, 5117], 'formation': [1111, 2581, 2656, 2870, 3158, 4844, 5118, 5169], 'rodent': [1113, 4846], 'cytokine': [1116, 4849], 'tumor-induced': [1118, 2403, 4851], '17DeLisser': [1145], 'Christofidou-Solomidou': [1147, 1177, 2362, 4571, 4641, 4855, 4885, 5290], 'M.': [1148, 1178, 1473, 2363, 2826, 4219, 4283, 4297, 4330, 4572, 4574, 4642, 4687, 4693, 4715, 4717, 4770, 4856, 4886, 5008, 5227, 5291, 5293], 'Strieter': [1149, 4857], 'Burdick': [1151, 4859], 'M.D.': [1152, 4860], 'Robinson': [1153, 4861], 'C.S.': [1154, 4862], 'Wexler': [1155, 4863], 'R.S.': [1156, 4864], 'Kerr': [1157, 4865], 'J.S': [1158, 4866], 'Garlanda': [1159, 1179, 4867, 4887], 'Merwin': [1161, 4869], 'J.R.': [1162, 4870], 'Albelda': [1165, 1806, 2382, 4579, 4873, 5298], 'Pathol.': [1169, 1215, 3275, 4700, 4755, 4877, 4979], '151:': [1171, 4879], '671-677PubMed': [1172, 4880], '18Zhou': [1175, 4883], 'Angiogenesis.': [1183, 4891], '1999;': [1184, 3254, 4527, 4892], '181-188Crossref': [1186, 4894], '(69)': [1189, 4897], 'model': [1201, 4965, 5091, 5635], 'chronic': [1203, 4967], 'inflammation': [1204, 4601, 4968], '(19Solowiej': [1205, 3265, 4745, 4969], 'Biswas': [1207, 3267, 4747, 4971], 'P.': [1208, 3268, 4281, 4300, 4308, 4405, 4630, 4748, 4972], 'Graesser': [1209, 3269, 4694, 4749, 4973], '162:': [1217, 3255, 3277, 4528, 4757, 4981], '953-962Abstract': [1218, 3278, 4758, 4982], 'Full': [1219, 1221, 3279, 3281, 4202, 4204, 4232, 4234, 4343, 4345, 4704, 4706, 4759, 4761, 4983, 4985, 5514, 5516], 'Text': [1220, 1222, 3280, 3282, 4203, 4205, 4233, 4235, 4344, 4346, 4705, 4707, 4760, 4762, 4984, 4986, 5515, 5517], 'PDF': [1223, 3283, 4206, 4236, 4347, 4708, 4763, 4987, 5518], '(80)': [1226, 3286, 4766, 4990], 'Studies': [1229, 3742, 4824], 'were': [1230, 1394, 1431, 1525, 1540, 1580, 1607, 1612, 1661, 1745, 1766, 1776, 1800, 1820, 1827, 1846, 1877, 1886, 1905, 1912, 1922, 1983, 2010, 2036, 2087, 2135, 2144, 2169, 2210, 2228, 2243, 2284, 2302, 2309, 2328, 2527, 2543, 2752, 2841, 2883, 3015, 3055, 3081, 3131, 3159, 3174, 3302, 3324, 3354, 3407, 3422, 3446, 3468, 3580, 3642, 3661, 3743, 5380], 'done': [1232, 2329, 3304], 'mouse': [1236, 2175, 3748], 'investigate': [1240, 2515, 3752], 'involvement': [1242, 2518, 3754], 'Using': [1247, 1565, 1965, 3412], 'strategy,': [1251], 'we': [1252, 3823, 5064, 5333], 'disrupts': [1270, 3776], 'initial': [1289, 3961], 'findings.': [1290], 'Specifically,': [1291], 'Finally,': [1306], 'PECAM-1-deficient': [1314, 3313, 3450, 3667, 3740, 5325], 'decreased': [1317, 2929, 4594, 4738, 5616], 'comparison': [1319, 3090, 3389], 'wild': [1326, 1398, 3319, 3343, 3391, 3402, 3455, 3542, 3575, 3645, 3664, 3698, 5346], 'type': [1327, 1399, 1813, 3320, 3344, 3392, 3403, 3456, 3543, 3576, 3646, 3665, 3699, 4268, 5347], 'first': [1345, 2487, 2586], 'ECs,': [1359, 3729], 'affects': [1360], 'Cells': [1362], 'Antibodies—Rat': [1364], '(RLMEC)': [1368], 'cultured': [1370, 1432, 1613], 'MCDB-31': [1372], 'medium': [1373, 1436, 1561, 1671, 3617], '(Invitrogen)': [1374], 'supplemented': [1375], 'l-glutamine,': [1377], 'hydrocortisone,': [1378], 'heparin,': [1379], 'supplement': [1383], '(Discovery': [1384], 'Laboratories,': [1385, 1741], 'Warrington,': [1386], 'PA),': [1387], '10%': [1389, 1858], 'serum.': [1390], 'immunomagnetically': [1396], 'PECAM-null': [1401], 'using': [1403, 1464, 1628, 1683, 1857, 2066, 2183, 2220, 2286, 2311, 2848, 3057], 'published': [1404], 'protocols': [1405], '(20Bowden': [1406], 'R.A.': [1407], 'Ding': [1408], 'Z.M.': [1409], 'Donnachie': [1410], 'E.M.': [1411], 'Petersen': [1412], 'T.K.': [1413], 'Michael': [1414], 'L.H.': [1415], 'Ballantyne': [1416], 'C.M.': [1417], 'Burns': [1418], 'A.R.': [1419, 4666], 'Circ.': [1420], 'Res.': [1421, 4171], '90:': [1423], '562-569Crossref': [1424], '(96)': [1427], 'EGM-2': [1434], 'MV': [1435], 'Cambrex': [1438], 'Bio': [1439], 'Science': [1440], 'Walkersville,': [1441], 'Inc': [1442, 2190], '(Walkersville,': [1443], 'MD).': [1444, 2225], 'binding': [1446], '(mAb)': [1450], '37': [1451, 2341, 2458, 2706], 'mAb': [1453, 2319, 2340, 2343, 2442, 2457, 2479, 2570, 2601, 2633, 2690, 2705, 2741, 2798, 2809, 2942, 2995, 3037, 3040, 3104, 3120, 3177, 3524, 4432], '62': [1454, 2443, 2480, 2602, 2943, 2996, 3525], 'RLMEC': [1456, 2346, 2398, 2434, 2470], 'determined': [1458, 1627, 1923, 1974, 2013, 2043, 2088, 2682, 2753], 'fluorescence-activated': [1460], 'sorting': [1462], 'analysis': [1463, 1568, 2288], 'previously': [1465, 1497, 4028], 'described': [1466, 1496], 'procedures': [1467], '(21Korhonen': [1468, 2821], 'Lahtinen': [1470, 2823], 'I.': [1471, 2369, 2824, 4245], 'Halmekyto': [1472, 2825], 'Alhonen': [1474, 2827], 'Janne': [1476, 2829], 'Dumont': [1478, 2831], 'Alitalo': [1480, 2833], 'K.': [1481, 2361, 2834, 4277, 4302, 5418], 'Blood.': [1482, 2835, 4585, 4616, 5304], '1995;': [1483, 2836, 4256], '86:': [1484, 2837], '828-835Crossref': [1485, 2838], 'Vitro': [1489, 1651], 'Wounding': [1490], 'Assay—Wound-induced': [1491], 'performed': [1494, 2118, 2182, 3744], 'Twenty-thousand': [1523], 'added': [1526], '24-well': [1528], 'culture': [1530, 1548], 'plates': [1531], 'allowed': [1533], 'grow': [1535], 'confluence.': [1537], 'Linear': [1538], 'defects': [1539, 4833], 'then': [1541, 1555, 1586, 1681, 1836, 2229, 2244, 2254, 3910], 'made': [1542, 2310], 'monolayer.': [1545], 'wounded': [1547], 'washed': [1550], 'phosphate-buffered': [1552], 'saline': [1553], 'incubated': [1556], '24': [1558, 1587, 1615], 'h': [1559, 1588, 1616, 1668], '(with': [1562, 2125], '1%': [1563], 'serum).': [1564], 'computer-assisted': [1566, 1915, 3026, 3413], 'image': [1567, 1916, 3092, 3414], 'Image-Pro': [1571], 'Plus': [1572], 'program': [1573], '(Media': [1574], 'Cybernetics,': [1575], 'Silver': [1576], 'Spring,': [1577], 'MD)': [1578], 'images': [1579, 2227], 'obtained': [1581, 1821, 1887, 2186, 2756, 3696], 'immediately': [1582, 3430], 'wounding': [1584], 'later,': [1589], 'distance': [1592], 'migrated': [1593], 'wound': [1598, 2437], 'edge': [1599], 'determined.': [1601], 'each': [1603, 2020, 2050, 2131, 2255, 3462], 'condition,': [1604], '3–5': [1605], 'wounds': [1606], 'analyzed.': [1608], 'Proliferation': [1610], 'Assay—Cells': [1611], '96-well': [1618], 'plates,': [1619], 'number': [1622, 1927, 2092], 'commercially': [1630], 'available': [1631], 'non-radioactive': [1632, 1643], 'colorimetric': [1633], 'assay': [1634, 1687, 1987, 2438], 'according': [1635], "manufacturer's": [1638], 'instructions': [1639], '(CellTiter': [1640], '96': [1641], 'AQueous': [1642], 'assay,': [1646], 'Promega,': [1647], 'Madison': [1648], 'WI).': [1649], 'Death': [1653], 'Detection—For': [1654], 'confluent': [1659], 'exposed': [1662], '5,': [1664], '24,': [1665], '48': [1667], 'serum-free': [1670], 'complete': [1673, 2647], 'medium,': [1674], 'antibody.': [1678], 'Apoptosis': [1679], 'assessed': [1682, 2065, 3550], 'APOPercentage': [1685], 'apoptosis': [1686, 3656, 5316, 5341], '(Bicolor': [1688], 'Ltd.,': [1689], 'Belfast.': [1690], 'Northern': [1691], 'Ireland)': [1692], 'absorbance': [1695], 'measured': [1696, 1913, 2842, 3423], '530': [1698], 'nm.': [1699], 'Animals—The': [1700], 'Institutional': [1701], 'Animal': [1702], 'Care': [1703], 'Utilization': [1705], 'Committees': [1706], 'both': [1708, 3707, 5088], "Children's": [1710], 'Hospital': [1711], 'Philadelphia': [1713], 'University': [1716], 'Pennsylvania': [1718], 'School': [1719], 'Medicine': [1721], 'approved': [1722], 'care': [1725], 'procedures.': [1726], 'Sprague-Dawley': [1736], 'rats': [1737, 2698, 2700], '(Charles': [1738], 'River': [1739], 'Breeding': [1740], 'North': [1742], 'Wilmington,': [1743], 'MA)': [1744], 'untreated': [1746, 2696, 3034, 3101], 'injected': [1748], 'intraperitoneally': [1749], 'saline,': [1751], 'non-immune': [1752], 'IgG,': [1753], 'every': [1757, 2207, 2529], 'other': [1758, 2530, 4663, 5202], 'day': [1759, 1762, 1769, 2531, 2539, 2546, 2758, 2844, 2934, 3327, 3330, 3347, 3371], 'beginning': [1760], '1.': [1763], 'animals': [1765, 2554, 2635, 2692, 2743, 2866, 2904, 3042, 3106, 3122, 3457, 3547, 3700, 4075, 5350], 'sacrificed': [1767], '15.': [1770, 2759, 2935], 'Separate': [1771], 'cohorts': [1772], 'also': [1777, 1815, 3303, 3549, 4265, 4795], '0.1': [1780, 1866], 'μg': [1781], 'dexamethasone': [1783], 'subcutaneously': [1784], 'days': [1786, 1830, 3583], '1–14,': [1787], 'known': [1790, 2909, 4184], 'inhibit': [1792, 2402], 'mice,': [1795, 1814, 3381, 3791], 'C57/Bl6': [1798, 1818], 'background,': [1799, 1819], 'kind': [1802], 'gift': [1803], 'Steven': [1805], '(University': [1807], 'Pennsylvania,': [1809], 'Philadelphia,': [1810], 'PA).': [1811], 'Wild': [1812], 'Taconic': [1823], '(Germantown,': [1824], 'NY).': [1825], 'Lungs': [1826], 'harvested': [1828, 1847], '1,': [1831, 2475, 2961, 3348], '7,': [1832, 3372], '14': [1834, 3586], 'week': [1838], '8': [1839, 3334, 3395, 3439], 'life.': [1841, 2549], 'Light': [1842], 'Electron': [1844, 2617], 'Microscopy—Lungs': [1845], 'inflation': [1849], 'pressure': [1852], '20': [1854], 'cm': [1855], 'H20': [1856], 'formalin': [1859], '(paraffin': [1860], 'sections)': [1861], '2.5%': [1863], 'glutaraldehyde': [1864], 'm': [1867], 'cacodylate': [1868], 'buffer': [1869], '(pH': [1870], '7.4)': [1871], '(for': [1872], 'electron': [1873, 1883], 'microscopy).': [1874], 'Paraffin': [1875], 'blocks': [1876, 3032, 4385], 'sectioned': [1878], 'H&E': [1880, 2203, 2684], 'staining,': [1881], 'whereas': [1882, 1980, 3373], 'microscopy': [1884, 2560, 2618], 'sections': [1885, 1900, 2685, 3019, 3080], 'post-fixation': [1889], '2%': [1891], 'osmium': [1892], 'tetroxide': [1893], 'embedding': [1895], 'epoxy': [1897], 'resin.': [1898], 'Sufficient': [1899], 'representative': [1902], 'serial': [1903, 3003], 'sampling': [1904], 'produced': [1906], 'reviewed.': [1908], 'Mean': [1909], 'areas': [1911, 3168, 3418, 3445], 'analysis,': [1917, 3415], 'radial': [1919, 2728, 3466, 3497], 'counts': [1921, 2748, 2751, 3467], 'counting': [1925], 'intersect': [1931], 'perpendicular': [1933], 'line': [1934], 'drawn': [1935], 'center': [1938], 'respiratory': [1941], 'bronchiole': [1942], 'distal': [1945], 'acinus': [1946], '(connective': [1947], 'septum': [1949], 'pleura)': [1951], '(22Cooney': [1952], 'T.P.': [1953], 'Thurlbeck': [1954], 'Thorax.': [1956], '1982;': [1957], '37:': [1958], '572-579Crossref': [1959], '(189)': [1962], 'paraffin': [1966], 'sections,': [1968, 2205, 3004], 'situ': [1970], 'immunohistochemical': [1976], 'staining': [1977, 1995], 'apoptotic': [1981, 4565], 'identified': [1984, 3051], 'TUNEL': [1986, 3659], '(R&D': [1988], 'Systems,': [1989], 'Minneapolis,': [1990], 'MN).': [1991], 'PCNA': [1994], 'noncapillary': [2002], 'vessels,': [2003], 'percentage': [2005, 2030], 'total': [2007, 2032], 'PCNA-positive': [2011, 2037], 'least': [2016, 2046, 2140, 5200], '30': [2017, 2711], 'mouse.': [2021, 2051], 'quantitation': [2024], '×40': [2040], 'field': [2041], '60': [2047], 'fields': [2048], 'Real-time': [2052], 'Reverse': [2053], 'Transcription-PCR—For': [2054], 'Tie-1': [2056, 2176, 3536, 3571], 'quantitative': [2057, 3501], 'real-time': [2058], 'reverse': [2059, 2158, 2179, 2851], 'transcription-PCR,': [2060], 'relative': [2061], 'mRNA': [2062, 2812, 2931, 3572], 'expression': [2063, 2086, 2854, 3537, 5014, 5617], 'polymerase-activated': [2067], 'fluorescent': [2068, 2102, 2128], 'PCR': [2069, 2094], 'probes': [2070], 'providing': [2071], 'continuous': [2072], 'message': [2073], 'quantification': [2074], 'during': [2075, 2106, 3189, 3520, 3971, 5455], 'amplification': [2076, 2122], '(TaqMan,': [2077], 'Applied': [2078, 2147, 2172], 'Biosystems,': [2079], 'Foster': [2080], 'City,': [2081], 'CA).': [2082], 'Differences': [2083], 'gene': [2085], 'comparing': [2090], 'cycles': [2095], 'achieve': [2098], 'threshold': [2100], 'above': [2104], 'background': [2105], 'exponential': [2108], 'phase': [2109], 'reaction.': [2112], 'Normalization': [2113], 'sample': [2115], 'loading': [2116], 'simultaneous': [2121], 'GAPDH': [2124, 2165], 'its': [2126, 5383, 5621], 'own': [2127], 'probe)': [2129], 'well.': [2132], 'All': [2133], 'reactions': [2134], 'carried': [2136], 'out': [2137], 'triplicate.': [2141], 'Specific': [2142], 'primers/probes': [2143, 2168], 'synthesized': [2145], "Biosystem's": [2148], 'oligo': [2149], 'synthesis': [2150, 2195], 'service': [2151], 'follows:': [2153], 'Tie1': [2154, 2811, 2930], 'forward': [2155], 'primer,': [2156, 2159], '5′-GCCCTTTTAGCCTTGGTGT-3′;': [2157], '5′-TTCACCCGATCCTGACTGGTA-3′;': [2160], 'probe,': [2162], '(5′-FAM': [2163], 'fluorescent-reporter)-AGCTGCCTACATCGGAGACGCACC-3′.': [2164], 'specific': [2167, 2251, 2857], 'purchased': [2170], 'Biosystems.': [2173], 'β-actin,': [2178], 'transcription-PCR': [2180], 'primer': [2184], 'pairs': [2185], 'R&D': [2188], 'Systems': [2189], 'Superscript': [2193], 'first-strand': [2194], 'system': [2196], 'Invitrogen.': [2198], 'Computer-generated': [2199], 'Reconstructions—Sixty': [2201], '5-μm-thick': [2202], 'taken': [2206], '5': [2208], 'μm,': [2209], 'imaged': [2211], 'Axiophot': [2214], 'Zeiss': [2215], 'microscope': [2216], 'low': [2218, 5336], 'magnification': [2219], 'Image': [2221], 'software': [2222, 2233], '(Scion,': [2223], 'Fredrick,': [2224], 'Serial': [2226], 'imported': [2230], 'SoftWoRx': [2232], '(Applied': [2234], 'Precision,': [2235], 'Issaquah,': [2236], 'WA)': [2237], 'form': [2239], 'three-dimensional': [2240, 3027, 3087, 3096], 'images.': [2241], 'Polygons': [2242], 'created': [2245], 'outlined': [2247], 'limits': [2249], 'structures,': [2252], 'polygon': [2256], 'assigned': [2258], 'volume': [2261], 'object': [2262], 'could': [2264], 'viewed': [2266], 'analyzed': [2268, 2285], 'three-dimensions.': [2270], 'More': [2271], 'details': [2272], 'provided': [2274], 'supplemental': [2277, 3208], 'online.': [2279], 'Statistical': [2280], 'Analyses—Differences': [2281], 'among': [2282], 'groups': [2283], 'one-way': [2287], 'variance.': [2290], 'Results': [2291], 'presented': [2293], 'means': [2295], '±': [2296, 2710, 2716, 2763, 2779, 2781, 2783, 2785], 'S.E.': [2297, 2764], 'When': [2298, 3340], 'statistically': [2299], 'significant': [2300, 3980], 'differences': [2301, 2882, 3398, 3652, 5344], 'found': [2303, 3205, 3428, 3760], '(p': [2304], '<': [2305, 2722, 2770], '0.05),': [2306], 'individual': [2307], 'comparisons': [2308], 'Bonferroni/Dunn': [2313], 'test.': [2314], 'Effect': [2315], 'Anti-PECAM-1': [2317, 4840], 'Antibody,': [2318], '62,': [2320, 2344, 2810, 3178, 4433], 'Rat': [2322, 2483], 'Microvascular': [2324], 'Endothelial': [2325, 2793, 3513], 'Cells—Initial': [2326], 'determine': [2331, 3306, 3552], 'effects': [2333, 4017, 4107, 4317, 4805, 5275, 5483], 'antibodies': [2336, 2353, 2465, 2526], 'against': [2337], 'human': [2338, 2404, 4906, 4912], 'vitro.': [2349], 'functionally': [2351, 5670], 'distinct': [2352], 'cross-react': [2354], '(23Nakada': [2358], 'M.T.': [2359], 'Amin': [2360], 'Sun': [2366, 2376, 4569, 4637, 5288], 'Gurubhagavatula': [2368], 'Heavner': [2370], 'G.A.': [2371], 'Taylor': [2372], 'A.H.': [2373], 'Paddock': [2374], 'Q-H.': [2377], 'Zehnder': [2378], 'J.L.': [2379], 'DeLissser': [2384], 'Immunol.': [2387, 3253, 4526, 4672], '164:': [2389], '452-462Crossref': [2390], '(102)': [2393], 'bind': [2396], '(Fig.': [2399, 2459, 2474, 2591, 2630, 2707, 2890, 2952, 2960, 3048, 3098, 3114, 3145, 3338, 3458, 3475, 3589, 3620, 3640, 3669, 4475, 4484, 4783, 5077, 5351, 5494], '1a),': [2400], 'dose-dependent': [2446], 'manner': [2447], '(data': [2448, 2874, 3600, 3710], 'shown': [2449, 2594, 4553], '100': [2451], 'μg/ml)': [2452], 'unaffected': [2455, 2940], '1b).': [2460], 'neither': [2462], 'effect': [2468], 'and/or': [2472, 2614, 4369, 4429, 5183, 5278, 5666], 'c': [2476, 2962], 'd).': [2478], 'Inhibits': [2481], 'Postnatal': [2482], 'Alveolarization—In': [2484], '2': [2488, 2587, 4269], 'weeks': [2489, 2588, 3335, 3440], 'period': [2495, 3973], 'Therefore,': [2513], 'potential': [2517], 'administered': [2528], '14,': [2540], '15': [2547, 2845], 'Untreated': [2550], 'IgG-treated': [2553], 'served': [2555], 'controls.': [2557], 'By': [2558, 3394], 'light': [2559], 'equivalently': [2562], 'inflated': [2563, 3316], 'lungs,': [2564], 'control': [2565, 2620, 2697, 2865], 'animals,': [2566, 2572], 'well': [2568, 3154, 3623, 4802, 4901, 4994, 5556], '37-treated': [2571, 3041, 3105], 'mesenchyme': [2577], 'increasing': [2579], 'time': [2583, 2850, 3463], 'over': [2584], 'life': [2590, 2847], '2a;': [2592], 'IgG).': [2596], 'contrast,': [2598], 'distorted': [2605], 'architecture,': [2607], 'sacs': [2610, 3365], 'poorly': [2612], 'developed': [2613, 4490], 'incomplete': [2615], 'alveoli.': [2616], 'appropriate': [2623, 2651, 3129], '2b).': [2631], '62-treated': [2634, 2691, 2742, 3121], 'structures': [2639, 3061, 3113, 3135, 3202], 'crests': [2644], 'few': [2646], 'alveoli,': [2648], 'suggesting': [2649, 3179, 4532], 'initiation': [2652], 'crest': [2655], 'occurred': [2658], 'completed.': [2666], 'Consistent': [2667, 3603], 'morphological': [2670], 'finding': [2674, 3291, 3608, 4775, 4955, 5081, 5474], 'mean': [2677, 2762, 3417, 3443], 'cross-sectional': [2678, 3487], 'area': [2680, 3488], '(μm2)': [2681], '50%': [2687], 'greater': [2688, 3448], 'when': [2693, 2772, 3452, 3687], 'compared': [2694, 2773, 3341, 3453, 3688], 'IgG': [2703], '2c;': [2708], '333': [2709], 'mm2': [2712], '(control)': [2713], 'versus': [2714], '486': [2715], '84': [2717], 'μm2': [2718], '(mAb': [2719], '62);': [2720], 'p': [2721, 2769], '0.001,': [2723], 'n': [2724], '=': [2725, 2766], '4–8).': [2726], 'counts,': [2730, 3499], 'another': [2731], 'index': [2732, 2816], 'progressive': [2734, 3494], 'significantly': [2737, 2928, 3447, 3469, 3685], 'fewer': [2738], 'intercepts': [2739], '(Table': [2744], '1).TABLE': [2745], '1Radial': [2746], 'Radial': [2749], 'Data': [2760], 'represent': [2761], '(n': [2765], '5–8;': [2767], '*,': [2768], '0.05': [2771], 'control).AntibodyControlIgGmAb': [2775], '37mAb': [2776], '62Radial': [2777], 'counts8.03': [2778], '0.037.90': [2780], '0.127.83': [2782], '0.077.50': [2784], '0.1*': [2786], 'Open': [2787], 'table': [2788], 'tab': [2792], 'Content': [2794, 3514], 'Is': [2795, 3515], 'Unaffected': [2796], '62—To': [2799], 'understand': [2800], 'possible': [2802], 'mechanism': [2805, 3733], 'action': [2807], 'levels,': [2813], 'content': [2820, 2895, 2932, 2938, 4483, 5084], 'real': [2849], 'transcription-PCR.': [2852], 'marker': [2860], 'increased': [2861, 4561, 5314], 'age': [2863], 'consistent': [2867, 5099], 'shown).': [2876, 3602, 3712], 'Significantly,': [2877], 'studies,': [2880, 4086], 'no': [2881, 3651, 5343], 'noted': [2884, 3378, 3522, 3662], 'any': [2886], 'antibody-treated': [2888], 'group': [2889], '2d),': [2891], 'indicating': [2892], 'affected': [2898, 3175, 3311, 3558], 'treatments.': [2901], 'As': [2902, 2936, 3477], 'expected,': [2903], 'dexamethasone,': [2907], 'inhibitor': [2910], '(3Massaro': [2913], 'vitro': [2949, 3775], 'wound-induced': [2950, 3672], '1b),': [2953], 'd),': [2964], 'disruption': [2970, 3736, 5374], 'PECAM-1-dependent': [2978, 5190], '(migration)': [2981], 'ECs.': [2988], 'Reconstructions': [2990], 'Reveal': [2991], 'Additional': [2992], 'Effects': [2993], 'Airway': [2998], 'Architecture—Upon': [2999], 'closer': [3000], 'examination': [3001], 'it': [3005], 'became': [3006], 'evident': [3007], 'some': [3009, 3126, 3374], 'enlarged': [3012], 'multiple': [3018, 4428], 'appeared': [3021, 3384], 'contiguous.': [3022], '300-μm': [3030], 'controls': [3035, 3102], '62-': [3038], 'further': [3044], 'analyze': [3045], 'airway': [3046, 3112, 5466], 'morphology': [3047], '3).': [3049, 3099, 5495], 'Objects': [3050], 'differentiated': [3056], 'colors,': [3058], 'designated': [3062, 3066, 3070, 3077], 'green,': [3063], 'blood': [3064], 'red,': [3067], 'airways': [3069, 3188, 5493], 'gray,': [3071], 'abnormal': [3073, 3156, 5269, 5627], 'contiguous': [3074], 'yellow.': [3078], 'Individual': [3079], 'contribute': [3084, 5371, 5693], 'picture': [3088], 'stacks': [3093], 'Both': [3100], 'normal-sized': [3108], '3,': [3115], 'c).': [3118], 'although': [3125, 4087], 'sizes': [3130], 'present,': [3132], 'larger': [3133, 3362], 'spanned': [3136], 'whole': [3138], 'length': [3139], 'block': [3143], '3b).': [3146], 'Incomplete': [3147], 'budding': [3148, 3940], 'tubules': [3152], 'noted.': [3160], 'indicate': [3163], 'even': [3165], 'ongoing': [3180], 'Movies': [3191], 'reconstructions': [3194], 'allow': [3196, 4544], 'better': [3198], 'visualization': [3199], 'can': [3203], 'on-line.': [3210], 'Impaired': [3211], 'Alveolarization': [3212], 'Mice': [3214, 3519], 'Deficient': [3215], 'PECAM-1—PECAM-1-null': [3217], '(24Duncan': [3221, 4494], 'Andrew': [3223, 4496], 'D.P.': [3224, 4497], 'Takimoto': [3225, 4498], 'Kaufman': [3227, 4500], 'S.A.': [3228, 4501], 'Yoshida': [3229, 4502], 'Spellberg': [3231, 4504], 'Luis': [3233, 4506], 'de': [3234, 4507], 'la': [3235, 4508], 'Pompa': [3236, 4509], 'Elia': [3238, 4511], 'Wakeham': [3240, 4513], 'Karan-Tamir': [3242, 4515], 'Muller': [3244, 4517, 4669], 'W.A.': [3245, 4518, 4670], 'Senaldi': [3246, 4519], 'Zukowski': [3248, 4521], 'M.M.': [3249, 4522], 'Mak': [3250, 4523, 4612], 'T.W.': [3251, 4524, 4613, 4668], '3022-3030PubMed': [3256, 4529], 'demonstrate': [3260], 'Given': [3289, 3534], 'disturbs': [3297, 3831], 'rats,': [3300, 5571], 'whether': [3307, 3553], 'Appropriately': [3315], '1': [3328, 3434, 3584], '7': [3331], '4a).': [3339], 'knock-out': [3352, 3546], 'notable': [3355], 'very': [3358], 'disorganized': [3359], 'architecture': [3360, 5486], 'thickened': [3367], 'walls.': [3369], 'On': [3370], 'mutant': [3380, 3812], 'retarded': [3387], 'weeks,': [3396], 'still': [3410], 'present.': [3411], 'assess': [3425], '(days': [3433], '7)': [3436], '(adult),': [3441], '4b).': [3459], 'point,': [3464], 'lower': [3470], '4c).': [3476], 'decrease': [3484], 'impairment': [3507], 'Preserved': [3516], 'Alveolarization—As': [3521], 'above,': [3523], 'altering': [3531], 'this,': [3535], 'Although': [3561], 'associated': [3567, 5625], 'levels': [3573], 'comparable': [3581, 3692], '5a).': [3590], 'protein': [3596], 'level': [3597, 5337], 'immunoblotting': [3599], 'small': [3615], 'sized': [3618], '5b),': [3621], '(including': [3628], 'microvessels)': [3633], 'within': [3634], '5c),': [3641], 'similar': [3643, 3705], 'animals.': [3649, 4793], '(detected': [3657], 'staining)': [3660], '5d).': [3670, 5352], '(5e).': [3701], 'types': [3709], 'functional': [3718], 'impairments': [3719], 'motility,': [3722], 'rather': [3723], 'than': [3724], 'Additionally,': [3806], 'migration.': [3817, 5111], 'Thus,': [3818, 4353, 5079, 5251, 5449, 5662], 'complimentary': [3821], 'approaches,': [3822], 'pulmonary': [3841, 3906, 3965, 5322], 'vasculature,': [3842, 3987], 'particular,': [3847], 'embryo,': [3853, 4808], 'develops': [3859], 'initially': [3860], 'separate': [3863], 'processes': [3866, 5203], '(9deMello': [3867], 'Peripherally,': [3889], 'network': [3892], 'arises': [3893], 'through': [3894, 3938], 'vasculogenesis': [3898], 'which': [3900], 'precursors,': [3902], 'recruited': [3903], 'mesenchyme,': [3907], 'differentiate': [3908], 'organize': [3911], 'sinusoidal': [3914], 'spaces.': [3915], '"blood': [3917], 'lakes"': [3918], 'undergo': [3919], 'subsequent': [3920, 4550], 'yield': [3923], 'connected': [3925], 'tree.': [3928], 'Centrally,': [3929], 'gives': [3931], 'rise': [3932], 'precapillary': [3936], 'branching': [3942], 'coalescence': [3952], 'peripheral': [3955, 3994], 'central': [3957], 'systems': [3958, 5092], 'completes': [3959], 'establishment': [3962], 'circulation.': [3966], 'Near': [3967], 'term,': [3968], 'particularly': [3970], 'septation,': [3976], 'density': [3984], 'intrapulmonary': [3986], 'studied': [4027], 'Jakkula': [4030], 'et': [4031, 5284], 'al.': [4032, 5285], 'who': [4057], 'reported': [4058], 'administration': [4060], 'three': [4062, 5201], 'antagonists': [4063, 4425], '(thalidomide,': [4066], 'VEGFR-2': [4071, 4322, 4395], 'inhibitor)': [4072], 'leads': [4076], 'simplification': [4079], 'attenuated': [4081], 'suggestive': [4088], 'interpreted': [4098], 'caution.': [4100], 'First,': [4101, 5207], 'fumagillin': [4102], 'thalidomide': [4104], 'independent': [4111], 'their': [4113, 5330], 'activities': [4115], '(25Griffith': [4116], 'E.C.': [4117], 'Niwayama': [4118], 'Ramsay': [4120], 'C.A.': [4121], 'Chang': [4122], 'Y.H.': [4123], 'Liu': [4124], 'J.O.': [4125], 'Proc.': [4126, 4148], 'Natl.': [4127, 4149], 'Acad.': [4128, 4150], 'Sci.': [4129, 4151], 'U.': [4130, 4152], '1998;': [4133, 4199, 4229, 4340, 4413], '95:': [4134], '15183-15188Crossref': [4135], '(236)': [4138], "26D'Amato": [4141], 'R.J.': [4142, 4168], 'Loughman': [4143], 'M.S.': [4144], 'Flynn': [4145], 'E.': [4146, 4253, 4291, 4634, 5229, 5435], 'Folkman': [4147], '1994;': [4155], '91:': [4156], '4082-4085Crossref': [4157], '(2355)': [4160], '27Kenyon': [4163], 'B.M.': [4164], 'Browne': [4165], 'F.': [4166, 4293, 4401], "D'Amato": [4167], 'Exp.': [4169], 'Eye': [4170], '64:': [4173], '971-978Crossref': [4174], '(443)': [4177], 'Second,': [4180, 5282], '(28Gerber': [4190], 'H.P.': [4191, 4213, 4324], 'Dixit': [4192, 4222, 4333], 'V.': [4193, 4223, 4275, 4334], 'Ferrara': [4194, 4224, 4335], 'Chem.': [4198, 4228, 4339, 4412], '273:': [4200, 4230, 4341], '13313-13316Abstract': [4201], '(835)': [4209], '29Gerber': [4212], 'McMurtrey': [4214, 4325], 'Kowalski': [4216, 4327], 'Yan': [4218, 4329], 'Keyt': [4220, 4331], 'B.A.': [4221, 4332], '30336-30343Abstract': [4231, 4342], '(1743)': [4239, 4350], '30Alon': [4242], 'T.': [4243, 4279], 'Hemo': [4244], 'Itinm': [4246], "Pe'er": [4248], 'Stone': [4250], 'Keshet': [4252, 4290], '1:': [4257], '1024-1028Crossref': [4258], '(1417)': [4261], 'differentiation': [4273, 5401, 5464], '(31Compernolle': [4274], 'Brusselmans': [4276], 'Acker': [4278], 'Hoet': [4280], 'Tjwa': [4282], 'Beck': [4284], 'Plaisance': [4286], 'Dor': [4288], 'Lupu': [4292], 'Nemery': [4294], 'Dewerchin': [4296], 'Van': [4298], 'Veldhoven': [4299], 'Plate': [4301], 'Moons': [4303], 'Collen': [4305], 'Carmeliet': [4307], '8:': [4312], '702-710Crossref': [4313], 'mediated': [4320], '(29Gerber': [4323], 'SU5416': [4359, 4384], 'due': [4362, 5186], 'epithelial': [4372, 5277, 5463], 'maturation': [4374], 'direct': [4378], 'Lastly,': [4383], 'platelet-derived': [4386], 'signaling': [4389], 'addition': [4391, 5194], '(32Sun': [4396], 'Tran': [4398], 'Tang': [4400, 4408], 'App': [4402], 'McMahon': [4406], '41:': [4414], '2588-2603Crossref': [4415], '(495)': [4418], 'potentially': [4427], 'undefined': [4430], 'effects,': [4431], 'reagent': [4436], '(i.e.': [4466], 'migration)': [4468], '1),': [4476], 'compromised': [4477], '2).': [4485], 'sufficient': [4542, 4815], 'adequate': [4546], 'embryonic': [4547, 4832], 'results': [4559], 'sensitivity': [4563], 'stress': [4566], '(33Gao': [4567, 5286], 'W.': [4570, 5289], 'Sawada': [4573, 5292], 'Bergom': [4577, 4718, 5296], 'Matsuyama': [4581, 5300], '102:': [4587, 5306], '169-179Crossref': [4588, 5307], '(105)': [4591, 4711, 5310], 'neutrophil': [4595], 'recruitment': [4596], 'response': [4598, 5683], 'interleukin-1-driven': [4600], '(34Thompson': [4602], 'R.D.': [4603], 'Noble': [4604], 'K.E.': [4605], 'Larb': [4606], 'K.Y.': [4607], 'Dewar': [4608], 'Duncan': [4610], 'Nourshargh': [4614], '2001;': [4617, 5426, 5441], '97:': [4618], '1854-1860Crossref': [4619], '(166)': [4622], '35Albelda': [4625], 'Lau': [4627], 'K.C.': [4628], 'Chien': [4629], 'Huang': [4631], 'Z.Y.': [4632], 'Arguiris': [4633], 'Bohen': [4635], 'Billet': [4639], 'Indik': [4643], 'Z.K.': [4644], 'Schreiber': [4645], 'A.D.': [4646], '31:': [4654], '246-255Crossref': [4655], '(26)': [4658], 'settings': [4664], '(36Schenkel': [4665], 'Chew': [4667], '173:': [4674], '6403-6408Crossref': [4675], '(128)': [4678], 'enhanced': [4681, 5360], 'susceptibility': [4682], 'endotoxic': [4684], 'shock': [4685], '(37Carrithers': [4686], 'Tandon': [4688], 'Michaud': [4692], '2005;': [4701, 4729], '166:': [4702], '185-196Abstract': [4703], '38Maas': [4714], 'Stapleton': [4716], 'Mattson': [4720], 'D.L.': [4721], '288:': [4730], 'H159-H164Crossref': [4731], '(89)': [4734], 'various': [4741], '6H.': [4769, 5007], 'DeLisser,': [4771, 5009], 'unpublished': [4772, 5010], 'data.': [4773, 5011], '4)': [4784], 'provides': [4785], 'additional': [4786], 'definition': [4787], 'phenotype': [4790], 'They': [4794], 'raise': [4796], 'possibility': [4798, 5358, 5469], 'earlier': [4804], 'magnitude': [4816], 'compromise': [4818], 'viability': [4820], 'underway': [4827], 'identify': [4829], 'subtle': [4831], 'PECAM-1.': [4839], '(17DeLisser': [4853], 'vascularization': [4904, 5002], 'tumors': [4909], 'grown': [4910], 'skin': [4913], 'grafts': [4914], 'transplanted': [4915], 'immunodeficient': [4917], 'conclusions': [4945], 'antibody-blocking': [4948], 'tumor': [4999], 'subcutaneous': [5004], 'Matrigel': [5005], 'implants.': [5006], 'motility': [5019], 'observed': [5065, 5313], 'impairs': [5074], '5e).': [5078], 'preserved': [5086], '(Figs.': 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