Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2125828985', 'doi': 'https://doi.org/10.1038/sj.onc.1210852', 'title': 'BRD–NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells', 'display_name': 'BRD–NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells', 'publication_year': 2007, 'publication_date': '2007-10-15', 'ids': {'openalex': 'https://openalex.org/W2125828985', 'doi': 'https://doi.org/10.1038/sj.onc.1210852', 'mag': '2125828985', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17934517'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/sj.onc.1210852', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S128439998', 'display_name': 'Oncogene', 'issn_l': '0950-9232', 'issn': ['0950-9232', '1476-5594'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1038/sj.onc.1210852', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5054314401', 'display_name': 'Christopher A. French', 'orcid': 'https://orcid.org/0000-0002-7434-4987'}, 'institutions': [{'id': 'https://openalex.org/I1283280774', 'display_name': "Brigham and Women's Hospital", 'ror': 'https://ror.org/04b6nzv94', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'C A French', 'raw_affiliation_strings': ["Department of Pathology Brigham and Women's Hospital Harvard Medical School Boston MA 02115 USA."], 'affiliations': [{'raw_affiliation_string': "Department of Pathology Brigham and Women's Hospital Harvard Medical School Boston MA 02115 USA.", 'institution_ids': ['https://openalex.org/I1283280774']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064196351', 'display_name': 'Cherie L. Ramirez', 'orcid': 'https://orcid.org/0000-0002-0397-6872'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'C L Ramirez', 'raw_affiliation_strings': ['Departments of Biological and Biomedical Sciences, Harvard Medical School, Boston, USA'], 'affiliations': [{'raw_affiliation_string': 'Departments of Biological and Biomedical Sciences, Harvard Medical School, Boston, USA', 'institution_ids': ['https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043822749', 'display_name': 'J Kolmakova', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I111088046', 'display_name': 'Boston University', 'ror': 'https://ror.org/05qwgg493', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I111088046']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J Kolmakova', 'raw_affiliation_strings': ['Boston University School of Medicine , Boston, USA'], 'affiliations': [{'raw_affiliation_string': 'Boston University School of Medicine , Boston, USA', 'institution_ids': ['https://openalex.org/I111088046']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014713306', 'display_name': 'Tyler Hickman', 'orcid': 'https://orcid.org/0000-0003-2623-3251'}, 'institutions': [{'id': 'https://openalex.org/I1283280774', 'display_name': "Brigham and Women's Hospital", 'ror': 'https://ror.org/04b6nzv94', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'T T Hickman', 'raw_affiliation_strings': ["Department of Pathology Brigham and Women's Hospital, Harvard Medical School Boston USA"], 'affiliations': [{'raw_affiliation_string': "Department of Pathology Brigham and Women's Hospital, Harvard Medical School Boston USA", 'institution_ids': ['https://openalex.org/I1283280774', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026552008', 'display_name': 'Michael J. Cameron', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1283280774', 'display_name': "Brigham and Women's Hospital", 'ror': 'https://ror.org/04b6nzv94', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'M J Cameron', 'raw_affiliation_strings': ["Department of Pathology Brigham and Women's Hospital, Harvard Medical School Boston USA"], 'affiliations': [{'raw_affiliation_string': "Department of Pathology Brigham and Women's Hospital, Harvard Medical School Boston USA", 'institution_ids': ['https://openalex.org/I1283280774', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026502208', 'display_name': 'M E Thyne', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1283280774', 'display_name': "Brigham and Women's Hospital", 'ror': 'https://ror.org/04b6nzv94', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'M E Thyne', 'raw_affiliation_strings': ["Department of Pathology Brigham and Women's Hospital, Harvard Medical School Boston USA"], 'affiliations': [{'raw_affiliation_string': "Department of Pathology Brigham and Women's Hospital, Harvard Medical School Boston USA", 'institution_ids': ['https://openalex.org/I1283280774', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005876566', 'display_name': 'Jeffery L. Kutok', 'orcid': 'https://orcid.org/0009-0009-9931-3106'}, 'institutions': [{'id': 'https://openalex.org/I1283280774', 'display_name': "Brigham and Women's Hospital", 'ror': 'https://ror.org/04b6nzv94', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J L Kutok', 'raw_affiliation_strings': ["Department of Pathology Brigham and Women's Hospital, Harvard Medical School Boston USA"], 'affiliations': [{'raw_affiliation_string': "Department of Pathology Brigham and Women's Hospital, Harvard Medical School Boston USA", 'institution_ids': ['https://openalex.org/I1283280774', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083229382', 'display_name': 'Jeffrey A. Toretsky', 'orcid': 'https://orcid.org/0000-0003-3619-2879'}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}, {'id': 'https://openalex.org/I184565670', 'display_name': 'Georgetown University', 'ror': 'https://ror.org/05vzafd60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I184565670']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J A Toretsky', 'raw_affiliation_strings': ['Department of Oncology, Lombardi Comprehensive Cancer Center and Pediatrics, Georgetown University, Washington, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, Lombardi Comprehensive Cancer Center and Pediatrics, Georgetown University, Washington, USA', 'institution_ids': ['https://openalex.org/I201448701', 'https://openalex.org/I184565670']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068815845', 'display_name': 'A K Tadavarthy', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1326929380', 'display_name': 'Allina Health', 'ror': 'https://ror.org/04esegk75', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1326929380']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'A K Tadavarthy', 'raw_affiliation_strings': ['Allina Hospitals and Clinics, Minneapolis, USA'], 'affiliations': [{'raw_affiliation_string': 'Allina Hospitals and Clinics, Minneapolis, USA', 'institution_ids': ['https://openalex.org/I1326929380']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031588652', 'display_name': 'Ursula R. Kees', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I175234967', 'display_name': 'Telethon Kids Institute', 'ror': 'https://ror.org/01dbmzx78', 'country_code': 'AU', 'type': 'facility', 'lineage': ['https://openalex.org/I175234967']}, {'id': 'https://openalex.org/I177877127', 'display_name': 'University of Western Australia', 'ror': 'https://ror.org/047272k79', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I177877127']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'U R Kees', 'raw_affiliation_strings': ['Telethon Institute for Child Health Research, and Centre for Child Health Research, The University of Western Australia, Perth, Australia'], 'affiliations': [{'raw_affiliation_string': 'Telethon Institute for Child Health Research, and Centre for Child Health Research, The University of Western Australia, Perth, Australia', 'institution_ids': ['https://openalex.org/I175234967', 'https://openalex.org/I177877127']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040359760', 'display_name': 'Jonathan A. Fletcher', 'orcid': 'https://orcid.org/0000-0002-5109-2588'}, 'institutions': [{'id': 'https://openalex.org/I1283280774', 'display_name': "Brigham and Women's Hospital", 'ror': 'https://ror.org/04b6nzv94', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J A Fletcher', 'raw_affiliation_strings': ["Department of Pathology Brigham and Women's Hospital, Harvard Medical School Boston USA"], 'affiliations': [{'raw_affiliation_string': "Department of Pathology Brigham and Women's Hospital, Harvard Medical School Boston USA", 'institution_ids': ['https://openalex.org/I1283280774', 'https://openalex.org/I136199984']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5029821721', 'display_name': 'Jon C. Aster', 'orcid': 'https://orcid.org/0000-0002-1957-9070'}, 'institutions': [{'id': 'https://openalex.org/I1283280774', 'display_name': "Brigham and Women's Hospital", 'ror': 'https://ror.org/04b6nzv94', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J C Aster', 'raw_affiliation_strings': ["Department of Pathology Brigham and Women's Hospital, Harvard Medical School Boston USA"], 'affiliations': [{'raw_affiliation_string': "Department of Pathology Brigham and Women's Hospital, Harvard Medical School Boston USA", 'institution_ids': ['https://openalex.org/I1283280774', 'https://openalex.org/I136199984']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 8, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4390, 'currency': 'EUR', 'value_usd': 5490, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.319, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 391, 'citation_normalized_percentile': {'value': 0.929208, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '27', 'issue': '15', 'first_page': '2237', 'last_page': '2242'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12534', 'display_name': 'Targeted Protein Degradation in Biomedical Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12534', 'display_name': 'Targeted Protein Degradation in Biomedical Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10649', 'display_name': 'Diagnosis and Treatment of Multiple Myeloma', 'score': 0.9966, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin-Proteasome Proteolytic Pathway', 'score': 0.9886, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/brd4', 'display_name': 'BRD4', 'score': 0.7497215}, {'id': 'https://openalex.org/keywords/oncogene-proteins', 'display_name': 'Oncogene Proteins', 'score': 0.49710396}, {'id': 'https://openalex.org/keywords/phd-finger', 'display_name': 'PHD finger', 'score': 0.4758527}, {'id': 'https://openalex.org/keywords/bet-bromodomains', 'display_name': 'BET Bromodomains', 'score': 0.438041}, {'id': 'https://openalex.org/keywords/nuclear-export-signal', 'display_name': 'Nuclear export signal', 'score': 0.4158938}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8333667}, {'id': 'https://openalex.org/C2779634854', 'wikidata': 'https://www.wikidata.org/wiki/Q18037206', 'display_name': 'BRD4', 'level': 5, 'score': 0.7497215}, {'id': 'https://openalex.org/C83640560', 'wikidata': 'https://www.wikidata.org/wiki/Q180951', 'display_name': 'Chromatin', 'level': 3, 'score': 0.60204077}, {'id': 'https://openalex.org/C29512474', 'wikidata': 'https://www.wikidata.org/wiki/Q16860021', 'display_name': 'Nuclear protein', 'level': 4, 'score': 0.5839413}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5298937}, {'id': 'https://openalex.org/C49805395', 'wikidata': 'https://www.wikidata.org/wiki/Q910966', 'display_name': 'Nuclear localization sequence', 'level': 3, 'score': 0.50791794}, {'id': 'https://openalex.org/C2909762590', 'wikidata': 'https://www.wikidata.org/wiki/Q207609', 'display_name': 'Oncogene Proteins', 'level': 4, 'score': 0.49710396}, {'id': 'https://openalex.org/C206391251', 'wikidata': 'https://www.wikidata.org/wiki/Q1186738', 'display_name': 'Nut', 'level': 2, 'score': 0.4912445}, {'id': 'https://openalex.org/C59157529', 'wikidata': 'https://www.wikidata.org/wiki/Q994741', 'display_name': 'Nuclear transport', 'level': 4, 'score': 0.49010238}, {'id': 'https://openalex.org/C123894998', 'wikidata': 'https://www.wikidata.org/wiki/Q425158', 'display_name': 'Fusion protein', 'level': 4, 'score': 0.48799983}, {'id': 'https://openalex.org/C92477616', 'wikidata': 'https://www.wikidata.org/wiki/Q7119217', 'display_name': 'PHD finger', 'level': 5, 'score': 0.4758527}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.4652646}, {'id': 'https://openalex.org/C74401373', 'wikidata': 'https://www.wikidata.org/wiki/Q1829843', 'display_name': 'Bromodomain', 'level': 4, 'score': 0.45292652}, {'id': 'https://openalex.org/C54757728', 'wikidata': 'https://www.wikidata.org/wiki/Q3511067', 'display_name': 'Nuclear export signal', 'level': 4, 'score': 0.4158938}, {'id': 'https://openalex.org/C2780114586', 'wikidata': 'https://www.wikidata.org/wiki/Q40260', 'display_name': 'Cell nucleus', 'level': 3, 'score': 0.38262323}, {'id': 'https://openalex.org/C165864922', 'wikidata': 'https://www.wikidata.org/wiki/Q411391', 'display_name': 'Regulation of gene expression', 'level': 3, 'score': 0.27699566}, {'id': 'https://openalex.org/C24284526', 'wikidata': 'https://www.wikidata.org/wiki/Q204785', 'display_name': 'Zinc finger', 'level': 4, 'score': 0.26426512}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.263542}, {'id': 'https://openalex.org/C64927066', 'wikidata': 'https://www.wikidata.org/wiki/Q36293', 'display_name': 'Histone', 'level': 3, 'score': 0.2567359}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.1901916}, {'id': 'https://openalex.org/C66938386', 'wikidata': 'https://www.wikidata.org/wiki/Q633538', 'display_name': 'Structural engineering', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C127413603', 'wikidata': 'https://www.wikidata.org/wiki/Q11023', 'display_name': 'Engineering', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C40767141', 'wikidata': 'https://www.wikidata.org/wiki/Q285697', 'display_name': 'Recombinant DNA', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002277', 'descriptor_name': 'Carcinoma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004847', 'descriptor_name': 'Epithelial Cells', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D015513', 'descriptor_name': 'Oncogene Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D015514', 'descriptor_name': 'Oncogene Proteins, Fusion', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D013736', 'descriptor_name': 'Testicular Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002277', 'descriptor_name': 'Carcinoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002277', 'descriptor_name': 'Carcinoma', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018797', 'descriptor_name': 'Cell Cycle Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002843', 'descriptor_name': 'Chromatin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002843', 'descriptor_name': 'Chromatin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004847', 'descriptor_name': 'Epithelial Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004847', 'descriptor_name': 'Epithelial Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005810', 'descriptor_name': 'Multigene Family', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015513', 'descriptor_name': 'Oncogene Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015513', 'descriptor_name': 'Oncogene Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015513', 'descriptor_name': 'Oncogene Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015514', 'descriptor_name': 'Oncogene Proteins, Fusion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015514', 'descriptor_name': 'Oncogene Proteins, Fusion', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D016601', 'descriptor_name': 'RNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016601', 'descriptor_name': 'RNA-Binding Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D016601', 'descriptor_name': 'RNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016601', 'descriptor_name': 'RNA-Binding Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D013736', 'descriptor_name': 'Testicular Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013736', 'descriptor_name': 'Testicular Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/sj.onc.1210852', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S128439998', 'display_name': 'Oncogene', 'issn_l': '0950-9232', 'issn': ['0950-9232', '1476-5594'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17934517', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/sj.onc.1210852', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S128439998', 'display_name': 'Oncogene', 'issn_l': '0950-9232', 'issn': ['0950-9232', '1476-5594'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 15, 'referenced_works': ['https://openalex.org/W1822770076', 'https://openalex.org/W1963869546', 'https://openalex.org/W1973462980', 'https://openalex.org/W1992127633', 'https://openalex.org/W1994939279', 'https://openalex.org/W2015496414', 'https://openalex.org/W2027417589', 'https://openalex.org/W2038256325', 'https://openalex.org/W2052692973', 'https://openalex.org/W2111901894', 'https://openalex.org/W2158076143', 'https://openalex.org/W2164154570', 'https://openalex.org/W2169944837', 'https://openalex.org/W2171258458', 'https://openalex.org/W2171262570'], 'related_works': ['https://openalex.org/W4283391028', 'https://openalex.org/W3201259715', 'https://openalex.org/W3021366882', 'https://openalex.org/W3004198684', 'https://openalex.org/W2916627146', 'https://openalex.org/W2740890103', 'https://openalex.org/W2519266411', 'https://openalex.org/W2227431445', 'https://openalex.org/W2063887542', 'https://openalex.org/W2006419402'], 'abstract_inverted_index': {'An': [0], 'unusual': [1], 'group': [2], 'of': [3, 31, 58, 73, 90, 100, 162, 168, 175, 185, 192], 'carcinomas,': [4], 'here': [5, 105], 'termed': [6], 'nuclear': [7, 83, 111, 164], 'protein': [8, 71], 'in': [9, 55, 139, 179, 195, 200], 'testis': [10], '(NUT)': [11], 'midline': [12], 'carcinomas': [13], '(NMC),': [14], 'are': [15, 129], 'characterized': [16], 'by': [17, 218], 'translocations': [18], 'that': [19, 53, 92, 108, 116, 133, 153, 167, 211], 'involve': [20], 'NUT,': [21], 'a': [22, 42, 70, 81, 121], 'novel': [23, 51], 'gene': [24, 44, 68], 'on': [25, 38, 62], 'chromosome': [26, 39, 63], '15.': [27], 'In': [28, 124], 'about': [29], '2/3rds': [30], 'cases,': [32], 'NUT': [33, 59, 91, 101, 109, 138], 'is': [34, 93, 102], 'fused': [35], 'to': [36, 60, 96, 216], 'BRD4': [37], '19.': [40], 'Using': [41], 'candidate': [43], 'approach,': [45], 'we': [46, 106, 181], 'identified': [47], 'two': [48, 74], 'NMCs': [49], 'harboring': [50], 'rearrangements': [52], 'result': [54], 'the': [56, 88, 134, 140, 172, 183], 'fusion': [57, 67, 177, 213], 'BRD3': [61], '9.': [64], 'The': [65, 98], 'BRD3–NUT': [66, 126, 157, 187], 'encodes': [69], 'composed': [72], 'tandem': [75], 'chromatin-binding': [76], 'bromodomains,': [77], 'an': [78], 'extra-terminal': [79], 'domain,': [80], 'bipartite': [82], 'localization': [84, 112], 'sequence,': [85], 'and': [86, 113, 127, 156, 188, 203, 222], 'almost': [87], 'entirety': [89], 'highly': [94], 'homologous': [95], 'BRD4–NUT.': [97], 'function': [99], 'unknown,': [103], 'but': [104], 'show': [107, 152], 'contains': [110], 'export': [114], 'sequences': [115], 'promote': [117], 'nuclear-cytoplasmic': [118], 'shuttling': [119], 'via': [120, 142], 'leptomycin-sensitive': [122], 'pathway.': [123], 'contrast,': [125], 'BRD4–NUT': [128, 155, 189], 'strictly': [130], 'nuclear,': [131], 'implying': [132], 'BRD': [135], 'moiety': [136], 'retains': [137], 'nucleus': [141], 'interactions': [143], 'with': [144, 147, 220, 224], 'chromatin.': [145], 'Consistent': [146], 'this': [148], 'idea,': [149], 'FRAP': [150], 'studies': [151], 'BRD4,': [154], 'have': [158], 'significantly': [159], 'slower': [160], 'rates': [161], 'lateral': [163], 'diffusion': [165], 'than': [166], 'NUT.': [169], 'To': [170], 'investigate': [171], 'functional': [173], 'role': [174], 'BRD–NUT': [176, 212], 'proteins': [178, 194, 214], 'NMCs,': [180], 'investigated': [182], 'effects': [184], 'siRNA-induced': [186], 'withdrawal.': [190], 'Silencing': [191], 'these': [193, 208], 'NMC': [196], 'cell': [197, 204], 'lines': [198], 'resulted': [199], 'squamous': [201], 'differentiation': [202], 'cycle': [205], 'arrest.': [206], 'Together,': [207], 'data': [209], 'suggest': [210], 'contribute': [215], 'carcinogenesis': [217], 'associating': [219], 'chromatin': [221], 'interfering': [223], 'epithelial': [225], 'differentiation.': [226]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2125828985', 'counts_by_year': [{'year': 2024, 'cited_by_count': 19}, {'year': 2023, 'cited_by_count': 32}, {'year': 2022, 'cited_by_count': 28}, {'year': 2021, 'cited_by_count': 30}, {'year': 2020, 'cited_by_count': 38}, {'year': 2019, 'cited_by_count': 23}, {'year': 2018, 'cited_by_count': 30}, {'year': 2017, 'cited_by_count': 28}, {'year': 2016, 'cited_by_count': 40}, {'year': 2015, 'cited_by_count': 23}, {'year': 2014, 'cited_by_count': 20}, {'year': 2013, 'cited_by_count': 21}, {'year': 2012, 'cited_by_count': 18}], 'updated_date': '2024-09-12T17:12:46.275699', 'created_date': '2016-06-24'}