Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2125716578', 'doi': 'https://doi.org/10.1161/hc3901.095769', 'title': 'Regulation of Endothelial Nitric Oxide Synthase Expression in the Vascular Wall and in Mononuclear Cells From Hypercholesterolemic Rabbits', 'display_name': 'Regulation of Endothelial Nitric Oxide Synthase Expression in the Vascular Wall and in Mononuclear Cells From Hypercholesterolemic Rabbits', 'publication_year': 2001, 'publication_date': '2001-10-09', 'ids': {'openalex': 'https://openalex.org/W2125716578', 'doi': 'https://doi.org/10.1161/hc3901.095769', 'mag': '2125716578', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11591621'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/hc3901.095769', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/hc3901.095769', 'source': {'id': 'https://openalex.org/S116251202', 'display_name': 'Circulation', 'issn_l': '0009-7322', 'issn': ['0009-7322', '1524-4539'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.ahajournals.org/doi/pdf/10.1161/hc3901.095769', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100779060', 'display_name': 'Ana Jiménez', 'orcid': 'https://orcid.org/0000-0003-0661-0750'}, 'institutions': [{'id': 'https://openalex.org/I4210129357', 'display_name': 'Hospital Universitario Fundación Jiménez Díaz', 'ror': 'https://ror.org/049nvyb15', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129357']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Ana Jiménez', 'raw_affiliation_strings': ['From the Fundación Jiménez Díaz, Cardiovascular Research and Hypertension Laboratory, Madrid, Spain.'], 'affiliations': [{'raw_affiliation_string': 'From the Fundación Jiménez Díaz, Cardiovascular Research and Hypertension Laboratory, Madrid, Spain.', 'institution_ids': ['https://openalex.org/I4210129357']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050206448', 'display_name': 'Maria Arriero', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210129357', 'display_name': 'Hospital Universitario Fundación Jiménez Díaz', 'ror': 'https://ror.org/049nvyb15', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129357']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'María M. Arriero', 'raw_affiliation_strings': ['From the Fundación Jiménez Díaz, Cardiovascular Research and Hypertension Laboratory, Madrid, Spain.'], 'affiliations': [{'raw_affiliation_string': 'From the Fundación Jiménez Díaz, Cardiovascular Research and Hypertension Laboratory, Madrid, Spain.', 'institution_ids': ['https://openalex.org/I4210129357']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054471328', 'display_name': 'Almudena López-Blaya', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210129357', 'display_name': 'Hospital Universitario Fundación Jiménez Díaz', 'ror': 'https://ror.org/049nvyb15', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129357']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Almudena López-Blaya', 'raw_affiliation_strings': ['From the Fundación Jiménez Díaz, Cardiovascular Research and Hypertension Laboratory, Madrid, Spain.'], 'affiliations': [{'raw_affiliation_string': 'From the Fundación Jiménez Díaz, Cardiovascular Research and Hypertension Laboratory, Madrid, Spain.', 'institution_ids': ['https://openalex.org/I4210129357']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043961914', 'display_name': 'Fernando González-Fernández', 'orcid': 'https://orcid.org/0000-0003-0663-1666'}, 'institutions': [{'id': 'https://openalex.org/I4210107964', 'display_name': 'Williams & Associates', 'ror': 'https://ror.org/01jncky63', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I4210107964']}, {'id': 'https://openalex.org/I4210129357', 'display_name': 'Hospital Universitario Fundación Jiménez Díaz', 'ror': 'https://ror.org/049nvyb15', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129357']}], 'countries': ['ES', 'US'], 'is_corresponding': False, 'raw_author_name': 'Fernando González-Fernandez', 'raw_affiliation_strings': ['From the Fundación Jiménez Díaz, Cardiovascular Research and Hypertension Laboratory, Madrid, Spain.', 'Lippincott Williams & Wilkins'], 'affiliations': [{'raw_affiliation_string': 'Lippincott Williams & Wilkins', 'institution_ids': ['https://openalex.org/I4210107964']}, {'raw_affiliation_string': 'From the Fundación Jiménez Díaz, Cardiovascular Research and Hypertension Laboratory, Madrid, Spain.', 'institution_ids': ['https://openalex.org/I4210129357']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103466054', 'display_name': 'Rosa García', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210129357', 'display_name': 'Hospital Universitario Fundación Jiménez Díaz', 'ror': 'https://ror.org/049nvyb15', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129357']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Rosa García', 'raw_affiliation_strings': ['From the Fundación Jiménez Díaz, Cardiovascular Research and Hypertension Laboratory, Madrid, Spain.'], 'affiliations': [{'raw_affiliation_string': 'From the Fundación Jiménez Díaz, Cardiovascular Research and Hypertension Laboratory, Madrid, Spain.', 'institution_ids': ['https://openalex.org/I4210129357']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053372078', 'display_name': 'Jose Fortés', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210129357', 'display_name': 'Hospital Universitario Fundación Jiménez Díaz', 'ror': 'https://ror.org/049nvyb15', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129357']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'José Fortes', 'raw_affiliation_strings': ['From the Fundación Jiménez Díaz, Cardiovascular Research and Hypertension Laboratory, Madrid, Spain.'], 'affiliations': [{'raw_affiliation_string': 'From the Fundación Jiménez Díaz, Cardiovascular Research and Hypertension Laboratory, Madrid, Spain.', 'institution_ids': ['https://openalex.org/I4210129357']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080784980', 'display_name': 'Inmaculada Millás', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210129357', 'display_name': 'Hospital Universitario Fundación Jiménez Díaz', 'ror': 'https://ror.org/049nvyb15', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129357']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Inmaculada Millás', 'raw_affiliation_strings': ['From the Fundación Jiménez Díaz, Cardiovascular Research and Hypertension Laboratory, Madrid, Spain.'], 'affiliations': [{'raw_affiliation_string': 'From the Fundación Jiménez Díaz, Cardiovascular Research and Hypertension Laboratory, Madrid, Spain.', 'institution_ids': ['https://openalex.org/I4210129357']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033401495', 'display_name': 'Sandra Velasco', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210107964', 'display_name': 'Williams & Associates', 'ror': 'https://ror.org/01jncky63', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I4210107964']}, {'id': 'https://openalex.org/I4210129357', 'display_name': 'Hospital Universitario Fundación Jiménez Díaz', 'ror': 'https://ror.org/049nvyb15', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129357']}], 'countries': ['ES', 'US'], 'is_corresponding': False, 'raw_author_name': 'Sandra Velasco', 'raw_affiliation_strings': ['From the Fundación Jiménez Díaz, Cardiovascular Research and Hypertension Laboratory, Madrid, Spain.', 'Lippincott Williams & Wilkins'], 'affiliations': [{'raw_affiliation_string': 'Lippincott Williams & Wilkins', 'institution_ids': ['https://openalex.org/I4210107964']}, {'raw_affiliation_string': 'From the Fundación Jiménez Díaz, Cardiovascular Research and Hypertension Laboratory, Madrid, Spain.', 'institution_ids': ['https://openalex.org/I4210129357']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064919338', 'display_name': 'Lourdes Sánchez de Miguel', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210129357', 'display_name': 'Hospital Universitario Fundación Jiménez Díaz', 'ror': 'https://ror.org/049nvyb15', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129357']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Lourdes Sánchez de Miguel', 'raw_affiliation_strings': ['From the Fundación Jiménez Díaz, Cardiovascular Research and Hypertension Laboratory, Madrid, Spain.'], 'affiliations': [{'raw_affiliation_string': 'From the Fundación Jiménez Díaz, Cardiovascular Research and Hypertension Laboratory, Madrid, Spain.', 'institution_ids': ['https://openalex.org/I4210129357']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049842143', 'display_name': 'Luís Rico', 'orcid': 'https://orcid.org/0000-0001-9354-3570'}, 'institutions': [{'id': 'https://openalex.org/I4210129357', 'display_name': 'Hospital Universitario Fundación Jiménez Díaz', 'ror': 'https://ror.org/049nvyb15', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129357']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Luis Rico', 'raw_affiliation_strings': ['From the Fundación Jiménez Díaz, Cardiovascular Research and Hypertension Laboratory, Madrid, Spain.'], 'affiliations': [{'raw_affiliation_string': 'From the Fundación Jiménez Díaz, Cardiovascular Research and Hypertension Laboratory, Madrid, Spain.', 'institution_ids': ['https://openalex.org/I4210129357']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101633873', 'display_name': 'Jerónimo Farré', 'orcid': 'https://orcid.org/0000-0002-2241-1252'}, 'institutions': [{'id': 'https://openalex.org/I4210129357', 'display_name': 'Hospital Universitario Fundación Jiménez Díaz', 'ror': 'https://ror.org/049nvyb15', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129357']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Jerónimo Farré', 'raw_affiliation_strings': ['From the Fundación Jiménez Díaz, Cardiovascular Research and Hypertension Laboratory, Madrid, Spain.'], 'affiliations': [{'raw_affiliation_string': 'From the Fundación Jiménez Díaz, Cardiovascular Research and Hypertension Laboratory, Madrid, Spain.', 'institution_ids': ['https://openalex.org/I4210129357']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102969498', 'display_name': 'Santos Casado', 'orcid': 'https://orcid.org/0000-0001-6073-3909'}, 'institutions': [{'id': 'https://openalex.org/I4210129357', 'display_name': 'Hospital Universitario Fundación Jiménez Díaz', 'ror': 'https://ror.org/049nvyb15', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129357']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Santos Casado', 'raw_affiliation_strings': ['From the Fundación Jiménez Díaz, Cardiovascular Research and Hypertension Laboratory, Madrid, Spain.'], 'affiliations': [{'raw_affiliation_string': 'From the Fundación Jiménez Díaz, Cardiovascular Research and Hypertension Laboratory, Madrid, Spain.', 'institution_ids': ['https://openalex.org/I4210129357']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5002160272', 'display_name': 'Antonio López‐Farré', 'orcid': 'https://orcid.org/0000-0003-0301-067X'}, 'institutions': [{'id': 'https://openalex.org/I4210129357', 'display_name': 'Hospital Universitario Fundación Jiménez Díaz', 'ror': 'https://ror.org/049nvyb15', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129357']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Antonio López-Farré', 'raw_affiliation_strings': ['From the Fundación Jiménez Díaz, Cardiovascular Research and Hypertension Laboratory, Madrid, Spain.'], 'affiliations': [{'raw_affiliation_string': 'From the Fundación Jiménez Díaz, Cardiovascular Research and Hypertension Laboratory, Madrid, Spain.', 'institution_ids': ['https://openalex.org/I4210129357']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.475, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 45, 'citation_normalized_percentile': {'value': 0.803514, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '104', 'issue': '15', 'first_page': '1822', 'last_page': '1830'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10155', 'display_name': 'Role of Nitric Oxide in Health and Disease', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10155', 'display_name': 'Role of Nitric Oxide in Health and Disease', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11178', 'display_name': 'Structure and Function of G Protein-Coupled Receptors', 'score': 0.9927, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11057', 'display_name': 'Pathophysiology of Myocardial Reperfusion Injury', 'score': 0.9894, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cerivastatin', 'display_name': 'Cerivastatin', 'score': 0.7909144}, {'id': 'https://openalex.org/keywords/endothelial-dysfunction', 'display_name': 'Endothelial Dysfunction', 'score': 0.496094}], 'concepts': [{'id': 'https://openalex.org/C2778326061', 'wikidata': 'https://www.wikidata.org/wiki/Q1761022', 'display_name': 'Enos', 'level': 4, 'score': 0.97781456}, {'id': 'https://openalex.org/C2779415389', 'wikidata': 'https://www.wikidata.org/wiki/Q423439', 'display_name': 'Cerivastatin', 'level': 4, 'score': 0.7909144}, {'id': 'https://openalex.org/C98539663', 'wikidata': 'https://www.wikidata.org/wiki/Q220599', 'display_name': 'Cytosol', 'level': 3, 'score': 0.6281702}, {'id': 'https://openalex.org/C2776992346', 'wikidata': 'https://www.wikidata.org/wiki/Q111140', 'display_name': 'Endothelium', 'level': 2, 'score': 0.60061574}, {'id': 'https://openalex.org/C105580179', 'wikidata': 'https://www.wikidata.org/wiki/Q188928', 'display_name': 'Messenger RNA', 'level': 3, 'score': 0.5398857}, {'id': 'https://openalex.org/C519581460', 'wikidata': 'https://www.wikidata.org/wiki/Q207843', 'display_name': 'Nitric oxide', 'level': 2, 'score': 0.52842504}, {'id': 'https://openalex.org/C2777622882', 'wikidata': 'https://www.wikidata.org/wiki/Q417619', 'display_name': 'Nitric oxide synthase', 'level': 3, 'score': 0.5256756}, {'id': 'https://openalex.org/C137061746', 'wikidata': 'https://www.wikidata.org/wiki/Q736033', 'display_name': 'Peripheral blood mononuclear cell', 'level': 3, 'score': 0.4407626}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.4341415}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.42123815}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.4012492}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.32811642}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.27369815}, {'id': 'https://openalex.org/C2778163477', 'wikidata': 'https://www.wikidata.org/wiki/Q43656', 'display_name': 'Cholesterol', 'level': 2, 'score': 0.123172194}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.09450355}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.09344265}, {'id': 'https://openalex.org/C2779519902', 'wikidata': 'https://www.wikidata.org/wiki/Q1240093', 'display_name': 'Pravastatin', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D006937', 'descriptor_name': 'Hypercholesterolemia', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D007963', 'descriptor_name': 'Leukocytes, Mononuclear', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D019001', 'descriptor_name': 'Nitric Oxide Synthase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011725', 'descriptor_name': 'Pyridines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D020413', 'descriptor_name': "3' Untranslated Regions", 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020413', 'descriptor_name': "3' Untranslated Regions", 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001011', 'descriptor_name': 'Aorta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001011', 'descriptor_name': 'Aorta', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D001011', 'descriptor_name': 'Aorta', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D003600', 'descriptor_name': 'Cytosol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003600', 'descriptor_name': 'Cytosol', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D019161', 'descriptor_name': 'Hydroxymethylglutaryl-CoA Reductase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019161', 'descriptor_name': 'Hydroxymethylglutaryl-CoA Reductase Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006937', 'descriptor_name': 'Hypercholesterolemia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006937', 'descriptor_name': 'Hypercholesterolemia', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D066298', 'descriptor_name': 'In Vitro Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007476', 'descriptor_name': 'Ionophores', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007476', 'descriptor_name': 'Ionophores', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D007963', 'descriptor_name': 'Leukocytes, Mononuclear', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007963', 'descriptor_name': 'Leukocytes, Mononuclear', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D007963', 'descriptor_name': 'Leukocytes, Mononuclear', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D046911', 'descriptor_name': 'Macromolecular Substances', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019001', 'descriptor_name': 'Nitric Oxide Synthase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019001', 'descriptor_name': 'Nitric Oxide Synthase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D052250', 'descriptor_name': 'Nitric Oxide Synthase Type III', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D011725', 'descriptor_name': 'Pyridines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020871', 'descriptor_name': 'RNA Stability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020871', 'descriptor_name': 'RNA Stability', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011817', 'descriptor_name': 'Rabbits', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013379', 'descriptor_name': 'Substrate Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014664', 'descriptor_name': 'Vasodilation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D014664', 'descriptor_name': 'Vasodilation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014665', 'descriptor_name': 'Vasodilator Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014665', 'descriptor_name': 'Vasodilator Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/hc3901.095769', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/hc3901.095769', 'source': {'id': 'https://openalex.org/S116251202', 'display_name': 'Circulation', 'issn_l': '0009-7322', 'issn': ['0009-7322', '1524-4539'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11591621', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/hc3901.095769', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/hc3901.095769', 'source': {'id': 'https://openalex.org/S116251202', 'display_name': 'Circulation', 'issn_l': '0009-7322', 'issn': ['0009-7322', '1524-4539'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 29, 'referenced_works': ['https://openalex.org/W1845418574', 'https://openalex.org/W1877992021', 'https://openalex.org/W1886375502', 'https://openalex.org/W1973592220', 'https://openalex.org/W1974573501', 'https://openalex.org/W2023236405', 'https://openalex.org/W2047624342', 'https://openalex.org/W2051048068', 'https://openalex.org/W2062637684', 'https://openalex.org/W2064951152', 'https://openalex.org/W2070597880', 'https://openalex.org/W2085728170', 'https://openalex.org/W2100837269', 'https://openalex.org/W2103636227', 'https://openalex.org/W2108116605', 'https://openalex.org/W2117164965', 'https://openalex.org/W2119470316', 'https://openalex.org/W2124210552', 'https://openalex.org/W2131399515', 'https://openalex.org/W2134812217', 'https://openalex.org/W2145570729', 'https://openalex.org/W2167866149', 'https://openalex.org/W2171675495', 'https://openalex.org/W2171737913', 'https://openalex.org/W2313326603', 'https://openalex.org/W2467782639', 'https://openalex.org/W4230558973', 'https://openalex.org/W4285719527', 'https://openalex.org/W4294216491'], 'related_works': ['https://openalex.org/W4300046402', 'https://openalex.org/W4211072399', 'https://openalex.org/W2415280815', 'https://openalex.org/W2380570571', 'https://openalex.org/W2375228892', 'https://openalex.org/W2125716578', 'https://openalex.org/W2070079602', 'https://openalex.org/W2067466145', 'https://openalex.org/W2005160306', 'https://openalex.org/W1543253499'], 'abstract_inverted_index': {'Background': [0], 'We': [1], 'recently': [2], 'obtained': [3], 'evidence': [4], 'demonstrating': [5], 'that': [6, 14, 194, 211], 'cultured': [7], 'bovine': [8], 'endothelial': [9, 22, 59], 'cells': [10, 151, 210], 'contain': [11], 'cytosolic': [12, 122, 141, 175], 'proteins': [13, 46], 'form': [15], 'complexes': [16], 'with': [17, 31, 82, 88, 143], 'the': [18, 42, 69, 137, 140, 144, 174, 188], '3′-untranslated': [19, 145], 'region': [20, 146], 'of': [21, 36, 44, 58, 85, 119, 127, 139, 147, 160, 173, 190], 'nitric': [23], 'oxide': [24], 'synthase': [25], '(eNOS)': [26], 'mRNA': [27, 165, 198], 'and': [28, 47, 62, 68, 112, 124, 135, 163, 167, 199, 208], 'are': [29, 212], 'associated': [30], 'its': [32], 'destabilization.': [33], 'The': [34], 'aim': [35], 'this': [37], 'study': [38], 'was': [39, 73, 107, 113], 'to': [40, 66, 196], 'determine': [41], 'presence': [43, 189], 'such': [45], 'eNOS': [48, 105, 128, 133, 148, 161, 164, 197, 202], 'expression': [49, 106, 134, 162, 203], 'in': [50, 55, 75, 109, 170, 201, 204], 'hypercholesterolemic': [51, 79, 86, 110, 153], 'rabbits': [52, 80, 87, 111, 154], 'as': [53], 'an': [54, 168], 'vivo': [56], 'model': [57], 'dysfunction.': [60], 'Methods': [61], 'Results': [63], 'Endothelium-dependent': [64], 'relaxation': [65], 'acetylcholine': [67], 'calcium': [70], 'ionophore': [71], 'A23187': [72], 'reduced': [74, 108, 125, 136], 'aortic': [76], 'segments': [77], 'from': [78, 152], 'compared': [81], 'controls.': [83], 'Treatment': [84], 'cerivastatin': [89, 182], '(0.1': [90], 'mg': [91], '·': [92, 97], 'kg': [93], 'body': [94], 'wt': [95], '−1': [96, 99], 'd': [98], ')': [100], 'restored': [101], 'endothelium-dependent': [102], 'relaxation.': [103], 'Aortic': [104], 'accompanied': [114], 'by': [115, 181, 214], 'enhanced': [116], 'binding': [117, 171], 'activity': [118, 172], 'a': [120, 157, 191], '60-kDa': [121, 192], 'protein': [123, 142, 193], 'stability': [126, 166], 'mRNA.': [129, 149], 'Cerivastatin': [130], 'treatment': [131], 'upregulated': [132], 'interaction': [138], 'Mononuclear': [150], 'also': [155, 179], 'showed': [156], 'marked': [158], 'reduction': [159], 'increase': [169], 'protein,': [176], 'which': [177], 'were': [178], 'prevented': [180, 213], 'treatment.': [183], 'Conclusions': [184], 'These': [185], 'results': [186], 'demonstrate': [187], 'binds': [195], 'reductions': [200], 'both': [205], 'vascular': [206], 'wall': [207], 'mononuclear': [209], 'cerivastatin.': [215]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2125716578', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-09-13T05:59:18.457237', 'created_date': '2016-06-24'}