Publication Information

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'https://openalex.org/W978066351'], 'related_works': ['https://openalex.org/W552858', 'https://openalex.org/W4255122707', 'https://openalex.org/W30132370', 'https://openalex.org/W2121006756', 'https://openalex.org/W2105424777', 'https://openalex.org/W2093012828', 'https://openalex.org/W2038444889', 'https://openalex.org/W2016105154', 'https://openalex.org/W2002268589', 'https://openalex.org/W1147750737'], 'abstract_inverted_index': {'Signal': [0, 112, 302, 379, 843, 3064, 4801, 5048, 5137, 5172], 'peptides': [1, 24, 56, 113, 136, 168, 498, 501, 540, 744, 759, 844, 1923, 2231, 3694, 3778, 3890, 4237, 4255, 4274, 4308, 4338, 5138, 5181], 'of': [2, 12, 54, 97, 105, 114, 124, 166, 209, 217, 256, 316, 331, 350, 444, 458, 495, 521, 535, 541, 557, 611, 671, 689, 710, 728, 742, 787, 831, 840, 852, 865, 879, 888, 936, 956, 966, 969, 988, 1045, 1067, 1083, 1147, 1152, 1162, 1209, 1223, 1263, 1310, 1343, 1422, 1431, 1490, 1500, 1514, 1539, 1569, 1676, 1683, 1697, 1706, 1735, 1754, 1783, 1798, 1814, 1855, 1918, 1935, 2037, 2133, 2144, 2166, 2189, 2194, 2275, 2312, 2337, 2344, 2387, 2398, 2415, 2422, 2547, 2564, 2570, 2586, 2598, 2609, 2685, 2713, 2748, 2750, 2754, 2758, 2760, 2766, 2772, 2776, 2791, 2817, 2839, 2852, 2854, 2866, 2877, 2882, 2896, 2904, 2913, 2934, 2951, 2974, 2982, 2999, 3031, 3038, 3099, 3151, 3164, 3256, 3294, 3338, 3353, 3382, 3443, 3458, 3489, 3503, 3531, 3582, 3592, 3601, 3620, 3660, 3715, 3731, 3753, 3772, 3776, 3782, 3823, 3843, 3865, 3900, 4006, 4172, 4205, 4235, 4265, 4282, 4316, 4326, 4334, 4349, 4414, 4421, 4481, 4556, 4561, 4586, 4598, 4605, 4617, 4625, 4633, 4644, 4657, 4676, 4698, 4703, 4750, 4758, 4858, 4866, 4883, 4899, 4968, 5028, 5040, 5081, 5139, 5179, 5210, 5304, 5323, 5338], 'secretory': [3, 115], 'and': [4, 29, 116, 141, 252, 281, 449, 468, 686, 754, 828, 862, 896, 919, 927, 1000, 1013, 1017, 1090, 1102, 1169, 1171, 1198, 1225, 1329, 1394, 1444, 1591, 1628, 1634, 1691, 1701, 1709, 1740, 1757, 1766, 1786, 1802, 1836, 1859, 1879, 1896, 1904, 1908, 1928, 2001, 2030, 2092, 2104, 2124, 2198, 2221, 2230, 2295, 2316, 2339, 2404, 2450, 2578, 2689, 2717, 2887, 2944, 3054, 3084, 3088, 3105, 3111, 3155, 3175, 3192, 3211, 3312, 3371, 3375, 3414, 3505, 3515, 3711, 3762, 3826, 3857, 3926, 3976, 3993, 4018, 4026, 4030, 4081, 4211, 4309, 4331, 4355, 4363, 4477, 4484, 4497, 4547, 4569, 4705, 4836, 4896, 5031, 5059, 5149, 5310, 5366, 5376, 5378], 'membrane': [5, 117, 254, 280, 398, 945, 1906, 1967, 2003, 3394, 3422, 3551, 3817, 4098, 4212, 4262, 4304, 4425, 4623, 4701, 5150, 5345], 'proteins': [6, 14, 45, 118, 126, 157, 251, 255, 824, 2004, 2032, 2106, 2212, 2317, 2377, 3525, 4029, 4038, 4099, 4327, 4459, 4470, 4480, 5141], 'are': [7, 34, 119, 146, 259, 304, 394, 2813, 2890, 3851, 3891, 4257, 4471, 4493, 4549, 5034, 5296], 'generated': [8, 120, 4940], 'by': [9, 121, 311, 848, 984, 1010, 1015, 1053, 1059, 1088, 1108, 1187, 1194, 1196, 1200, 1419, 1612, 1689, 1768, 1851, 1873, 1889, 2007, 2035, 2064, 2110, 2186, 2215, 2234, 2320, 2330, 2380, 2443, 2674, 2779, 2793, 2824, 3096, 3199, 3225, 3369, 3699, 3872, 3938, 3978, 4153, 4263, 4290, 4708, 4806, 4945, 4961, 4982], 'proteolytic': [10, 122, 902, 3149], 'processing': [11, 53, 123, 165, 494, 741, 878, 899, 913, 933, 959, 2129, 2981, 3181, 3222, 3275, 3313, 3333, 3483, 3581, 3846, 3863, 4005, 4132, 4604, 4803, 5174, 5307, 5341], 'precursor': [13, 125, 228, 309, 384, 3262, 4283, 4500, 4943], 'after': [15, 127, 2303, 3120, 3137], 'insertion': [16, 128, 4213, 5151], 'into': [17, 109, 129, 221, 283, 465, 946, 1304, 3003, 3056, 3301, 3342, 3973, 5195], 'the': [18, 30, 37, 52, 85, 93, 98, 103, 110, 130, 142, 149, 164, 197, 205, 210, 215, 222, 276, 284, 308, 317, 322, 329, 332, 348, 351, 357, 383, 397, 442, 445, 450, 455, 459, 466, 509, 589, 609, 672, 679, 690, 707, 721, 729, 733, 740, 835, 841, 856, 859, 869, 872, 877, 880, 924, 928, 937, 944, 947, 953, 957, 964, 970, 996, 1028, 1084, 1097, 1103, 1163, 1172, 1188, 1216, 1308, 1311, 1341, 1378, 1400, 1403, 1408, 1441, 1592, 1681, 1803, 1837, 1905, 2128, 2179, 2187, 2388, 2393, 2399, 2423, 2548, 2557, 2561, 2565, 2571, 2576, 2595, 2599, 2610, 2619, 2632, 2646, 2683, 2687, 2703, 2739, 2745, 2751, 2773, 2777, 2808, 2818, 2825, 2855, 2860, 2883, 2902, 2920, 2932, 2935, 2939, 2942, 2945, 2952, 2972, 2975, 2983, 3027, 3036, 3048, 3057, 3071, 3094, 3097, 3106, 3132, 3147, 3245, 3257, 3261, 3291, 3295, 3302, 3339, 3343, 3366, 3373, 3380, 3385, 3393, 3401, 3405, 3409, 3415, 3421, 3424, 3431, 3441, 3444, 3450, 3456, 3490, 3501, 3529, 3540, 3543, 3550, 3566, 3570, 3583, 3593, 3599, 3613, 3616, 3652, 3657, 3661, 3673, 3677, 3706, 3716, 3732, 3744, 3751, 3758, 3765, 3773, 3780, 3810, 3820, 3830, 3870, 3874, 3880, 3884, 3895, 3898, 3924, 3931, 3936, 3939, 3961, 3965, 3974, 3982, 4001, 4007, 4024, 4085, 4095, 4101, 4109, 4116, 4131, 4169, 4173, 4241, 4249, 4260, 4287, 4302, 4314, 4317, 4322, 4340, 4346, 4365, 4412, 4415, 4419, 4424, 4465, 4482, 4507, 4553, 4584, 4603, 4606, 4615, 4618, 4622, 4626, 4642, 4655, 4674, 4699, 4754, 4815, 4821, 4826, 4849, 4864, 4867, 4951, 4956, 4965, 4969, 4973, 4979, 5038, 5041, 5051, 5056, 5061, 5068, 5075, 5079, 5082, 5087, 5101, 5106, 5109, 5177, 5183, 5190, 5196, 5199, 5208, 5302, 5320, 5324, 5333], 'endoplasmic': [19, 131, 224, 277], 'reticulum': [20, 132, 225, 278], 'membrane.': [21, 133, 324, 842, 870, 4971, 5070], 'Liberated': [22, 134, 5194], 'signal': [23, 55, 63, 99, 135, 167, 175, 211, 267, 312, 334, 461, 497, 505, 523, 539, 673, 708, 723, 743, 758, 882, 893, 897, 911, 917, 940, 971, 2400, 2600, 2612, 2985, 3062, 3107, 3116, 3152, 3156, 3179, 3184, 3220, 3251, 3258, 3273, 3285, 3297, 3387, 3410, 3447, 3481, 3545, 3585, 3605, 3679, 3718, 3746, 3777, 3838, 3844, 3858, 3876, 3889, 3932, 3979, 3984, 4009, 4154, 4175, 4206, 4236, 4254, 4273, 4291, 4347, 4608, 4627, 4827, 4851, 4884, 4921, 4952, 4962, 4974, 5043, 5062, 5090, 5115, 5192, 5202, 5305, 5326, 5339], 'can': [25, 137, 386, 4197, 4503, 5205], 'be': [26, 138, 387, 748, 846, 2590, 3610, 3927, 3987, 4198, 4248, 4504, 5356], 'further': [27, 139, 1860, 2900, 5300], 'processed,': [28, 140, 3413], 'resulting': [31, 143, 390, 1005, 1048, 1077, 2664, 3042, 4076], 'N-terminal': [32, 107, 144, 219, 266, 456, 519, 3029, 3061, 3292, 3340, 3416, 3491, 3594, 3674, 3707, 5083], 'fragments': [33, 145, 392, 867, 1461, 5204], 'released': [35, 147, 306, 395, 464, 1850, 3092, 3300, 3419, 5110], 'toward': [36, 148, 732, 834, 2815, 2938, 3423, 4313, 5086], 'cytosol,': [38, 150, 3344], 'where': [39, 151, 1510, 3305, 3404, 3757, 3968], 'they': [40, 152, 337], 'may': [41, 153, 503, 845, 3827, 4159, 4247, 5112, 5142, 5318, 5355], 'interact': [42, 154], 'with': [43, 70, 155, 182, 264, 597, 682, 992, 1157, 1229, 1333, 1384, 1402, 1449, 1465, 1566, 1623, 1673, 1694, 1703, 1751, 1761, 2009, 2305, 2309, 2334, 2631, 2652, 2662, 2710, 2879, 3124, 3348, 3356, 3360, 3511, 3528, 3664, 3953, 3964, 4016, 4032, 4100, 4108, 4120, 4753, 4814, 5332], 'target': [44, 156], 'like': [46, 158], 'calmodulin.': [47, 159], 'We': [48, 160, 930, 2582, 2616, 3287, 4092, 5369], 'show': [49, 161, 931, 3579], 'here': [50, 162, 4344, 5188, 5354], 'that': [51, 84, 163, 196, 269, 393, 493, 502, 554, 706, 789, 854, 909, 932, 1039, 1405, 2410, 2437, 2539, 2560, 2584, 2670, 2801, 2859, 2995, 3272, 3281, 3290, 3526, 3580, 3730, 3743, 3850, 3934, 4003, 4194, 4256, 4408, 4632, 4646, 4652, 4679, 4767, 4848, 4860, 4916, 4987, 5064, 5108, 5335], 'requires': [57, 169, 3276, 3847], 'a': [58, 71, 170, 183, 262, 513, 522, 529, 550, 717, 849, 981, 1395, 1425, 1434, 1445, 1540, 1613, 1617, 1638, 1771, 1890, 1900, 2066, 2113, 2381, 2413, 2439, 2666, 2729, 2789, 2840, 2910, 2989, 3121, 3518, 3685, 3769, 3783, 3957, 4135, 4163, 4297, 4638, 4650, 4658, 4748, 4759, 4763, 4771, 4888, 4900, 4920, 4942, 4983, 5119, 5272], 'protease': [59, 75, 171, 187, 853, 889, 2435, 2550, 2733, 2761, 2828, 2847, 2869, 3165, 3171, 3231, 3247, 3280, 4002, 4651, 4808, 4985, 5290], 'activity': [60, 66, 172, 178, 1211, 3186], 'distinct': [61, 173, 514, 901, 3283, 4318], 'from': [62, 174, 307, 382, 396, 517, 868, 943, 1096, 1519, 1974, 2402, 2702, 2797, 2875, 3093, 3260, 3284, 3365, 3420, 3449, 4240, 4259, 4307, 4339, 4776, 4919, 4941, 5100, 5182], 'peptidase.': [64, 176, 3286], 'This': [65, 177, 2658, 2741, 4635, 4691, 5089], 'is': [67, 179, 270, 326, 463, 555, 676, 687, 714, 907, 2786, 3282, 3299, 3334, 3389, 3407, 3412, 3418, 3484, 3587, 3607, 3681, 3748, 3779, 3813, 3920, 4214, 4305, 4356, 4426, 4581, 4600, 4611, 4629, 4770, 4804, 4811, 4917, 4939, 4958, 4976], 'inhibited': [68, 180, 3178, 3224, 3250, 4130, 4805], 'specifically': [69, 181, 595, 2836], 'newly': [72, 184, 3168], 'developed': [73, 185, 3169], 'cysteine': [74, 186, 2549, 2732, 2755, 2821, 2827, 2846, 2868, 3170, 3230, 4807], 'inhibitor,': [76, 188, 3232], '1,3-di-(N-carboxybenzoyl-l-leucyl-l-leucyl)amino': [77, 189, 237], 'acetone': [78, 190, 994], '((Z-LL)2': [79, 191, 2636], 'ketone).': [80, 192], 'Inhibitor': [81, 193], 'studies': [82, 194], 'revealed': [83, 195, 4747], 'final,': [86, 198], '(Z-LL)2': [87, 199, 976, 1817, 2715, 2781, 2885, 3173, 3206, 3349, 3383, 3506, 3535, 4128, 5294], 'ketone-sensitive': [88, 200], 'cleavage': [89, 201, 895, 954, 3066, 3154, 3311, 3653, 3662, 3668, 3724, 3885, 3958, 4239, 4409, 4599, 4681, 4695, 4823], 'event': [90, 202], 'occurs': [91, 203, 4410, 4904], 'within': [92, 204, 825, 858, 4423, 4696, 4762, 4825, 4978, 5074], 'hydrophobic': [94, 206, 2416, 2596, 2633, 3622, 3766], 'transmembrane': [95, 207, 826, 860, 967, 3755, 3774, 4329, 4479, 4559, 4588, 4619, 4661, 4683, 4764, 4980, 5076], 'region': [96, 208, 861, 968, 1381, 3614, 3623, 3775, 4662, 4981, 5077], 'peptide,': [100, 212, 2986, 4010, 4609], 'thus': [101, 213, 3696], 'promoting': [102, 214], 'release': [104, 216, 727, 830, 864, 935, 3255, 3337, 3352, 3367, 3442, 3488, 3591, 4323, 4333, 4898, 5033, 5080, 5099, 5178], 'an': [106, 218, 265, 518, 598, 986, 2863, 3787, 3996, 4311, 4912], 'fragment': [108, 220, 1262, 3417, 4087, 4137, 5045, 5092], 'cytosol.': [111, 223, 734, 948, 3602, 5088], 'β-': [226], 'amyloid': [227, 4508], 'protein': [229, 236, 273, 310, 832, 1710, 3263, 3824, 3854, 3941, 4209, 4284, 4335, 4367, 4944, 5147], 'preprolactin': [230, 447, 2403, 4607, 5191], 'rough': [231, 1516, 1742, 1969, 2195, 3005, 3039, 4013], 'microsomes': [232, 1517, 1562, 1670, 1743, 1758, 1970, 2038, 2200, 3006, 3347, 3364, 3374, 3504, 3849, 4014, 4123], 'sterol': [233], 'regulatory': [234, 4474], 'element-binding': [235, 4475], 'acetone.': [238, 1707], 'BOC,': [239], 'di-t-butoxycarbonyl-': [240], 'biotin': [241, 1021, 1068, 2675, 2690], 'polyacrylamide': [242], 'gel': [243], 'electrophoresis': [244], '3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonic': [245], 'acid': [246, 1056, 1411, 1700, 1876, 2218, 2323, 2390, 2446, 3713], 'N,N-bis(2-hydroxyethyl)glycine': [247], 'O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium': [248], 'hexafluorophosphate': [249], 'Secretory': [250], 'most': [253, 2749, 2853, 3452, 4150, 4253], 'eukaryotic': [257], 'cells': [258, 1214], 'expressed': [260], 'as': [261, 353, 355, 923, 1027, 1034, 1469, 1716, 1774, 1914, 2544, 2606, 2764, 2788, 2924, 2958, 2960, 3879, 4119, 4264, 4293, 4342, 4832, 5186, 5293, 5364], 'pre-protein': [263], 'sequence': [268, 524, 553, 894, 2391, 3065, 3108, 3153, 3259, 3719, 3859, 4922], 'essential': [271], 'for': [272, 1036, 1176, 1207, 1300, 1321, 1376, 1429, 1453, 1493, 1554, 1604, 1714, 1722, 1726, 1841, 1865, 1881, 1912, 1921, 2099, 2118, 2209, 2225, 2351, 2593, 2720, 3026, 3205, 3214, 3336, 3486, 3589, 3705, 3883, 4252, 4300, 4345, 4891, 5189, 5373, 5381], 'targeting': [274, 3942, 4210, 5148], 'to': [275, 341, 470, 527, 559, 720, 726, 747, 900, 961, 1071, 1314, 1407, 1417, 1597, 1679, 1809, 1877, 2039, 2141, 2177, 2219, 2324, 2556, 2738, 2894, 3047, 3308, 3455, 3521, 3539, 3609, 3729, 3815, 3835, 3893, 3922, 3930, 3960, 3999, 4022, 4034, 4084, 4115, 4162, 4278, 4464, 4506, 4512, 4552, 4602, 4631, 4641, 4778, 4820, 4855, 5037, 5094, 5105, 5299, 5349, 5359], '(ER)1': [279], 'entry': [282, 2998, 3818], 'translocon': [285, 3896, 3925, 3937], '(1Walter': [286], 'P.': [287, 400, 773, 801, 1354, 1360, 1523, 4220, 4783], 'Johnson': [288, 1355, 4059], 'A.E.': [289, 4060], 'Annu.': [290], 'Rev.': [291], 'Cell': [292, 364, 1362, 1949, 1985, 5157], 'Biol.': [293, 365, 426, 1288, 1363, 1478, 1653, 3635, 3798, 4182, 4224, 5158], '1994;': [294], '10:': [295], '87-119Crossref': [296], 'PubMed': [297, 374, 411, 436, 485, 583, 632, 665, 781, 814, 1253, 1296, 1367, 1486, 1531, 1663, 2025, 2053, 2263, 2488, 2533, 3018, 3325, 3473, 3645, 3802, 3914, 4050, 4070, 4186, 4228, 4386, 4448, 4529, 4739, 4796, 4934, 5007, 5023, 5132, 5167, 5233, 5265, 5286], 'Scopus': [298, 375, 412, 437, 486, 584, 633, 666, 815, 1254, 1368, 1532, 1664, 2026, 2054, 2264, 2489, 2534, 3019, 3326, 3474, 3646, 3803, 3915, 4051, 4071, 4187, 4229, 4387, 4397, 4449, 4530, 4542, 4669, 4740, 4797, 4876, 5008, 5133, 5168, 5234, 5266], '(719)': [299], 'Google': [300, 377, 414, 439, 488, 586, 635, 668, 701, 782, 817, 1256, 1297, 1370, 1487, 1534, 1666, 2028, 2056, 2266, 2491, 2536, 3021, 3328, 3476, 3648, 3805, 3917, 4053, 4073, 4189, 4231, 4389, 4399, 4451, 4532, 4544, 4671, 4742, 4799, 4878, 4935, 5010, 5024, 5135, 5170, 5236, 5268, 5287], 'Scholar).': [301, 378, 440, 489, 587, 669, 702, 783, 818, 1371, 1488, 1667, 1962, 1998, 2057, 2267, 3022, 3329, 3477, 3649, 3806, 4074, 4190, 4232, 4400, 4452, 4545, 4672, 4743, 4800, 4879, 4936, 5025, 5136, 5171, 5288], 'sequences': [303, 4207], 'usually': [305], 'peptidase': [313, 918, 2614, 3185, 3980, 4155, 4853, 4886, 4963, 5049], 'during': [314, 3837], 'passage': [315], 'growing': [318], 'polypeptide': [319], 'chain': [320, 1386, 1455, 1458, 5054], 'through': [321, 1616, 1770, 3517], 'ER': [323, 352, 1966, 4097, 4261, 4303, 4483, 5057, 5069, 5184, 5344], 'Little': [325], 'known': [327, 3892], 'about': [328, 2931], 'fate': [330, 4234], 'liberated': [333, 381, 496, 3983, 4494], 'peptides.': [335, 3533, 3666], 'However,': [336, 4269, 4621], 'have': [338, 342, 745, 766, 951, 3288, 4160, 4275, 4685, 4840, 5144], 'been': [339, 768, 796, 4276, 4687], 'postulated': [340], 'important': [343], 'biological': [344, 2872], 'functions': [345, 4280, 5145], 'both': [346, 1073, 2411, 2575, 2626, 2686, 2714], 'in': [347, 356, 391, 472, 508, 532, 569, 716, 739, 760, 770, 963, 980, 1043, 1061, 1078, 1114, 1212, 1331, 1340, 1497, 1545, 1637, 1732, 1780, 1790, 1832, 1899, 1932, 2069, 2112, 2272, 2341, 2624, 2644, 2665, 2697, 2916, 2992, 3035, 3086, 3392, 3430, 3497, 3500, 3549, 3565, 3598, 3612, 3700, 3750, 3786, 3809, 3853, 3946, 4168, 4208, 4270, 4321, 4328, 4358, 4411, 4583, 4614, 4654, 4682, 4774, 4863, 4905, 5055, 5067, 5096, 5118, 5308, 5312, 5330], 'lumen': [349, 5058], 'well': [354, 2591, 4215], 'cytosol': [358, 467, 5197], '(2Martoglio': [359, 5152], 'B.': [360, 362, 418, 420, 424, 475, 479, 1268, 1284, 1645, 1647, 1651, 1942, 1946, 1978, 1982, 2017, 2244, 2471, 2516, 3008, 3012, 3315, 3319, 3463, 3467, 3627, 3629, 3633, 3795, 4392, 4664, 4871, 5122, 5126, 5153, 5155], 'Dobberstein': [361, 423, 478, 1283, 1650, 1945, 1981, 2016, 3011, 3318, 3466, 3632, 5125, 5154], 'Trends': [363, 5156], '1998;': [366, 629, 662, 2485, 3799, 4062, 5159, 5230, 5262], '8:': [367, 5160], '410-415Abstract': [368, 5161], 'Full': [369, 371, 431, 433, 1293, 1483, 1658, 1660, 2050, 3640, 3642, 3911, 4047, 4065, 4067, 4381, 4383, 4443, 4445, 4524, 4526, 4734, 4736, 5002, 5004, 5162, 5164], 'Text': [370, 372, 432, 434, 1294, 1484, 1659, 1661, 2051, 3641, 3643, 3912, 4048, 4066, 4068, 4382, 4384, 4444, 4446, 4525, 4527, 4735, 4737, 5003, 5005, 5163, 5165], 'PDF': [373, 435, 1295, 1485, 1662, 2052, 3644, 3913, 4049, 4069, 4385, 4447, 4528, 4738, 5006, 5166], '(441)': [376, 5169], 'peptides,': [380, 4292], 'protein,': [385], 'processed': [388, 715, 847, 3133, 3445, 3611, 3928, 3988, 4082, 4114, 4505, 4977], 'further,': [389], '(3Klappa': [399], 'Dierks': [401], 'T.': [402], 'Zimmermann': [403], 'R.': [404, 477, 803, 1352, 3010, 3317, 3465, 4785, 5124], 'Eur.': [405, 577], 'J.': [406, 425, 481, 578, 626, 695, 696, 776, 1286, 1287, 1356, 1477, 1652, 2021, 2240, 2258, 2482, 2502, 3014, 3321, 3469, 3634, 3796, 4180, 4372, 4434, 4718, 4720, 4929, 4993, 5018, 5128, 5227, 5281], 'Biochem.': [407], '1996;': [408], '239:': [409], '509-518Crossref': [410], '(21)': [413], 'Scholar,4Lyko': [415], 'F.': [416, 617, 1643, 3625, 5218], 'Martoglio': [417, 1267, 1644, 3626], 'Jungnickel': [419, 1646, 3628], 'Rapoport': [421, 1281, 1648, 3630], 'T.A.': [422, 1282, 1649, 2477, 2510, 3631], 'Chem.': [427, 1289, 1479, 1654, 2484, 2529, 3636], '1995;': [428, 1655, 2022, 3637], '270:': [429, 1656, 3638], '19873-19878Abstract': [430, 1657, 3639], '(85)': [438, 1665, 3647], 'In': [441, 735, 871, 3243, 3379, 3400, 3558, 3995, 4453, 4578], 'case': [443], 'hormone': [446], '(p-Prl)': [448], 'human': [451, 2405], 'immunodeficiency': [452, 2406], 'virus-1': [453, 2407], 'gp160,': [454], 'portion': [457, 520, 731, 942, 3293, 5085], 'respective': [460, 1379, 4558], 'peptide': [462, 515, 709, 857, 866, 898, 912, 941, 1173, 1217, 2401, 2562, 2601, 2613, 3117, 3134, 3157, 3180, 3221, 3274, 3298, 3341, 3388, 3411, 3448, 3482, 3546, 3562, 3586, 3595, 3606, 3680, 3735, 3747, 3832, 3839, 3845, 3877, 3933, 3985, 4176, 4348, 4509, 4628, 4802, 4852, 4885, 4902, 4975, 5044, 5063, 5084, 5091, 5111, 5173, 5203, 5306, 5327, 5340], 'binds': [469, 3307, 5093], 'Ca2+/calmodulin': [471, 938, 3309, 5095], 'vitro': [473, 1332, 1464, 2993, 3701, 3947, 5097, 5309], '(5Martoglio': [474, 3007, 3314, 3462, 5121], 'Graf': [476, 3009, 3316, 3464, 5123], 'EMBO': [480, 2020, 3013, 3320, 3468, 5127], '1997;': [482, 580, 698, 1250, 2260, 3015, 3322, 3470, 4521, 4731, 5129], '16:': [483, 3016, 3323, 3471, 5130], '6636-6645Crossref': [484, 3017, 3324, 3472, 5131], '(117)': [487, 3020, 3327, 3475, 5134], 'These': [490, 703, 819, 2553, 2926, 3269, 3577, 4191, 4469, 4845], 'findings': [491, 4846], 'imply': [492], 'releases': [499], 'functional': [500, 3852, 4901], 'influence': [504, 5113], 'transduction': [506, 5116], 'pathways': [507, 5117], 'cell.': [510], 'More': [511], 'recently,': [512], 'derived': [516, 4918], 'was': [525, 978, 1007, 1025, 1041, 1051, 1069, 1086, 1205, 1220, 1302, 1326, 1382, 1415, 1438, 1451, 1595, 1687, 1724, 1800, 1805, 1834, 2097, 2170, 2175, 2184, 2328, 2650, 2655, 2660, 2671, 2736, 2862, 3033, 3109, 3118, 3135, 3202, 3223, 3537, 3547, 3563, 3950, 4106, 4113, 4138, 4149, 4403, 4706], 'found': [526, 769, 2538, 3390, 3429, 3548], 'play': [528], 'crucial': [530], 'role': [531, 4204, 5303], 'immune': [533], 'surveillance': [534], 'healthy': [536], 'cells.': [537, 5314], 'The': [538, 973, 1004, 1020, 1047, 1063, 1081, 1202, 1685, 2095, 2182, 2326, 2641, 2795, 2830, 2844, 3041, 3113, 3167, 3194, 3603, 3667, 3723, 3807, 3841, 4075, 4146, 4203, 4233, 4401, 4595, 4880, 4907, 4937, 5026, 5347], 'polymorphic': [542], 'major': [543, 562, 5211], 'histocompatibility': [544, 563, 5212], 'complex': [545, 564, 594, 5213], 'class': [546, 565, 612, 711, 786, 4857, 5214], 'I': [547, 566, 613, 712, 4571, 4593, 5215], 'molecules': [548, 567, 713, 2566, 5216], 'contain': [549, 2412, 2438], 'highly': [551], 'conserved': [552, 4773], 'capable': [556], 'binding': [558, 939, 2580], 'so-called': [560, 791], 'non-polymorphic': [561], '(HLA-E': [568], 'human)': [570], '(6Braud': [571], 'V.': [572], 'Jones': [573], 'E.Y.': [574], 'McMichael': [575, 659, 5259], 'A.': [576, 646, 693, 810, 1249, 1276, 2242, 4792, 5246], 'Immunol.': [579, 697], '27:': [581], '1164-1169Crossref': [582], '(396)': [585], 'At': [588], 'cell': [590, 1099, 1105, 2705, 5120], 'surface,': [591], 'this': [592, 2431], 'peptide-HLA-E': [593], 'interacts': [596], 'inhibitory': [599], 'receptor': [600], 'on': [601, 678, 1607, 1807, 2102, 2361, 2419, 2430, 2567, 5207], 'natural': [602], 'killer': [603], '(NK)': [604], 'cells,': [605, 4455], 'thereby': [606, 3253], 'monitoring': [607, 5337], 'indirectly': [608], 'level': [610], 'molecule': [614], 'expression': [615], '(7Borrego': [616, 5217], 'Ulbrecht': [618, 5219], 'M.': [619, 1232, 1236, 2252, 5220], 'Weiss': [620, 5221], 'E.H.': [621, 5222], 'Coligan': [622, 5223], 'J.E.': [623, 1948, 1984, 5224], 'Brooks': [624, 5225], 'A.G.': [625, 5226], 'Exp.': [627, 5228], 'Med.': [628, 2483, 2528, 5229], '187:': [630, 5231], '813-818Crossref': [631, 5232], '(596)': [634, 5235], 'Scholar,': [636, 2492, 4054, 4390, 4533, 5011], '8Braud': [637], 'V.M.': [638, 5238], 'Allan': [639, 5239], 'D.S.': [640, 2455, 2498, 5240], "O'Callaghan": [641, 5241], 'C.A.': [642, 2473, 2518, 5242], 'Soderstrom': [643, 5243], 'K.': [644, 1358, 2552, 5244], "D'Andrea": [645, 5245], 'Ogg': [647, 5247], 'G.S.': [648, 5248], 'Lazetic': [649, 5249], 'S.': [650, 809, 1248, 1266, 1280, 1944, 1980, 2013, 4791, 5250], 'Young': [651, 5251], 'N.T.': [652, 5252], 'Bell': [653, 5253], 'J.I.': [654, 5254], 'Phillips': [655, 5255], 'J.H.': [656, 5256], 'Lanier': [657, 5257], 'L.L.': [658, 5258], 'A.J.': [660, 1274, 5260], 'Nature.': [661, 4536, 5261], '391:': [663, 5263], '795-799Crossref': [664, 5264], '(1770)': [667, 5267], 'Presentation': [670], 'peptide-derived': [674], 'epitope': [675], 'dependent': [677], 'transporter': [680], 'associated': [681, 4028], 'antigen': [683], 'presentation': [684], '(TAP)': [685], 'independent': [688], 'proteasome': [691, 1210, 2921, 2977], '(9Bai': [692], 'Forman': [694], '159:': [699], '2139-2146PubMed': [700], 'results': [704, 2796, 3270, 3578, 4192], 'suggest': [705, 4847], 'manner': [718], 'analogous': [719, 4601], 'p-Prl': [722, 881, 1301, 1494, 2984, 3001, 3032, 3296, 3446, 3496, 3584, 3604, 3678, 3717, 3745, 3875, 4008, 4174, 5042, 5053], 'sequence,': [724, 4953], 'leading': [725], 'epitope-containing': [730], 'eukaryotes,': [736], 'proteases': [737, 765, 820, 921, 1183, 2822, 4645, 4678, 4859, 5362], 'involved': [738, 4320, 4357], 'yet': [746, 4266], 'characterized': [749], 'or': [750, 837, 1134, 1547, 1827, 1885, 2201, 2783, 4337, 5198, 5270], 'identified.': [751], 'Protease': [752], 'IV': [753], 'oligopeptidase': [755], 'A': [756, 784, 904, 1116, 1951, 1987, 5071], 'process': [757, 4402, 4772], 'Escherichia': [761], 'coli,': [762], 'but': [763], 'homologous': [764], 'not': [767, 1259, 2891, 2964, 2970, 3068, 4427, 4686], 'eukaryotes': [771], '(10Novak': [772], 'Dev': [774], 'I.K.': [775], 'Bacteriol.': [777, 4930, 5019, 5282], '1988;': [778], '170:': [779], '5067-5075Crossref': [780], 'new': [785, 905], 'metalloproteases': [788, 4752], 'catalyze': [790], 'intramembrane': [792, 4405, 4461, 4648, 4768, 5351], 'proteolysis': [793, 3836, 4422, 4462, 4769, 4895, 5352], 'has': [794, 4351, 4591], 'recently': [795], 'discovered': [797], '(11Rudner': [798, 4780], 'D.Z.': [799, 4781], 'Fawcett': [800, 4782], 'Losick': [802, 4784], 'Proc.': [804, 1243, 4786], 'Natl.': [805, 1244, 4787], 'Acad.': [806, 1245, 4788], 'Sci.': [807, 1246, 4789], 'U.': [808, 1247, 2248, 4790], '1999;': [811, 2530, 4225, 4394, 4537, 4666, 4793, 4873, 4931, 5020, 5283], '96:': [812, 1529, 4794], '14765-14770Crossref': [813, 4795], '(189)': [816, 4798], 'cleave': [821, 4861], 'their': [822, 3051, 3060, 4557], 'substrate': [823, 3882], 'regions': [827, 4330, 4560, 4684], 'promote': [829, 4680, 5176], 'domains': [833, 4336, 4492], 'cytoplasmic': [836], 'exoplasmic': [838, 5200], 'side': [839, 2421, 2569, 3426, 4967], 'similar': [850, 2911, 5036], 'type': [851, 4562, 4570, 4592, 4597, 4659], 'cleaves': [855, 4653, 5050], 'facilitates': [863, 3440], 'present': [873], 'study,': [874], 'we': [875, 891, 950, 2433, 2693, 2908, 2987, 3159, 3345, 3362, 3493, 3655, 3868, 3955, 4011], 'characterize': [876, 4000], 'peptide.': [883, 972, 4828, 5193], 'By': [884], 'using': [885, 995, 1111, 1143, 2065, 2236, 2919, 3873, 4200, 5342], 'different': [886, 3162], 'types': [887], 'inhibitors,': [890], 'ascribe': [892], 'activities.': [903], 'inhibitor': [906, 975, 1825, 2734, 2848, 3227, 3248, 3406, 3571], 'introduced': [908, 1439], 'prevents': [910], 'efficiently': [914], 'without': [915, 1669, 3182, 3569, 3897], 'affecting': [916, 3183], 'other': [920, 1810, 2180, 5140], 'such': [922, 2559, 4831, 5292, 5316, 5363], 'lysosomal': [925, 2820, 2867, 2897], 'cathepsins': [926], 'proteasome.': [929, 2940], 'promotes': [934], 'Furthermore,': [949, 5315], 'determined': [952, 1142, 3198], 'site': [955, 2397, 2747, 2775, 2955, 4167, 4824], 'final': [958], 'reaction': [960, 1387, 2183, 3403, 3568], 'lie': [962], 'center': [965, 3752, 4585, 4616, 4656], 'ketone': [974, 977, 1033, 1165, 1168, 2541, 2572, 2691, 2716, 2719, 2782, 2785, 2886, 2889, 2906, 2947, 3174, 3177, 3207, 3216, 3350, 3536, 4129, 5295], 'synthesized': [979, 1026, 2618], 'single': [982, 2841, 3686], 'step': [983], 'coupling': [985, 997], 'excess': [987, 3523], 'commercially': [989], 'available': [990], 'Z-LL-OH': [991], 'diamino': [993], 'reagent': [998], 'HATU': [999], 'collidine': [1001], '(Fig.1': [1002, 2427], 'B).': [1003, 2640, 2679], 'product': [1006, 3663, 3669, 3725], 'then': [1008, 1185, 2672, 4031, 4093], 'isolated': [1009, 3083], 'column': [1011], 'chromatography': [1012], 'identified': [1014, 4688, 4707], 'NMR': [1016, 1089], 'mass': [1018, 1091], 'spectrometry.': [1019, 1092], 'derivative,': [1022], '(Bio-LL)2': [1023, 1079, 1167, 1821, 2718, 2784, 2888, 2946, 3176, 3215], 'ketone,': [1024, 1818, 1822, 3384], 'corresponding': [1029, 3561], 'di-t-butoxycarbonyl-capped': [1030], 'derivative': [1031, 1050, 2623, 2659, 2669], '(BOC-LL)2': [1032], 'described': [1035, 1470, 1717, 1775, 1915, 5046], '(Z-LL)2ketone,': [1037, 4817], 'except': [1038, 1215], 'BOC-LL-OH': [1040], 'used': [1042, 1070, 1206, 1221, 1452, 2988], 'place': [1044], 'Z-LL-OH.': [1046], 'BOC-capped': [1049], 'de-protected': [1052, 2661], 'brief': [1054], 'trifluoroacetic': [1055], 'treatment': [1057, 2008, 2304, 2876, 3359], 'followed': [1058, 1193, 4289], 'precipitation': [1060], 'ether.': [1062], 'activated,': [1064], 'nitrophenyl': [1065], 'ester': [1066], 'alkylate': [1072], 'free': [1074], 'N': [1075, 2627, 3691], 'termini,': [1076], 'ketone.': [1080, 3507], 'identity': [1082], 'compound': [1085, 2643, 2742, 2832], 'confirmed': [1087], 'Extracts': [1093], 'were': [1094, 1141, 1155, 1184, 1227, 1462, 1495, 1552, 1563, 1610, 1671, 1712, 1749, 1759, 1778, 1788, 1839, 1849, 1869, 1887, 1910, 1930, 1971, 2005, 2033, 2059, 2107, 2139, 2213, 2223, 2232, 2270, 2307, 2318, 2349, 2358, 2378, 2629, 2708, 3045, 3074, 3082, 3091, 3103, 3509, 3695, 3971, 4078], 'prepared': [1095, 1518, 1713, 1880, 1911, 1973, 2224], 'dendritic': [1098, 2704], 'line': [1100, 1106, 2706], 'DC2.4': [1101, 1148, 2707, 2798], 'fibroblast': [1104], 'NIH-3T3': [1107, 1213, 2917], 'mechanical': [1109], 'disruption': [1110], 'glass': [1112], 'beads': [1113], 'buffer': [1115, 1571, 1622, 2071, 2146, 2277, 3368, 3376], '(50': [1117, 1572], 'mmTris,': [1118], 'pH': [1119, 1130, 1135, 1575, 2041, 2076, 2149], '5.5,': [1120], '1': [1121, 1585, 1853, 2089, 2159, 2164, 2172, 2210, 2310, 2374, 2639], 'mm': [1122, 1127, 1573, 1578, 1582, 1586, 1589, 1599, 1625, 1763, 1829, 1857, 2074, 2079, 2083, 2087, 2090, 2152, 2156, 2160, 2280, 2283, 2288, 3513, 4020], 'dithiothreitol,': [1123, 1587, 2091, 2289], '5': [1124, 1605, 3721, 3737, 4142], 'mmMgCl2,': [1125], '250': [1126, 1588], 'sucrose)': [1128], 'at': [1129, 1179, 1337, 1399, 1424, 1440, 1557, 1631, 1729, 1844, 1862, 1893, 2121, 2206, 2354, 2723, 2802, 2833, 2956, 3050, 3234, 3277, 3684, 3689, 3819, 4456, 4947, 4964], '5.5': [1131], '(DC2.4': [1132], 'cells)': [1133], '7.4': [1136], '(NIH-3T3': [1137], 'cells).': [1138], 'Protein': [1139], 'concentrations': [1140, 1159, 2712, 2804, 2835, 2881, 2957], 'BCA': [1144], 'reagents.': [1145], 'Samples': [1146, 1551, 1560, 1668], 'lysates': [1149], '(100': [1150], 'μg': [1151], 'total': [1153], 'protein)': [1154], 'incubated': [1156, 1553, 2098, 2350, 2709, 3951, 4107], 'increasing': [1158, 2711], '(as': [1160], 'indicated)': [1161], 'two': [1164, 2936, 3617, 4700, 4948], 'inhibitors': [1166, 2436, 2546, 2608, 2884, 3172, 4830, 5291, 5317], '(Z-LL)2ketone': [1170, 1536, 2169, 2943], 'aldehyde': [1174, 1218], 'leupeptin': [1175, 2849], '30': [1177, 1555, 1558, 1730, 2100, 2119, 2207, 2721], 'min': [1178, 1556, 1606, 1728, 1843, 2101, 2120, 2353, 2722], 'room': [1180, 2724], 'temperature.': [1181], 'Cysteine': [1182], 'labeled': [1186, 1228, 3683], 'addition': [1189, 2188, 3098], 'of125I-JPM-565': [1190], '(∼106': [1191], 'cpm/sample)': [1192], 'separation': [1195], 'SDS-PAGE': [1197, 1715, 1882, 1913, 2226, 2235], 'analysis': [1199, 1208, 3530], 'autoradiography.': [1201], 'same': [1203], 'protocol': [1204], 'MG-132': [1219], 'instead': [1222, 4140], 'leupeptin,': [1224], 'samples': [1226, 1748, 1787, 1838, 2222, 2348, 2878], '125I-NLVS': [1230, 2923], '(12Bogyo': [1231], 'McMaster': [1233], 'J.S.': [1234], 'Gaczynska': [1235], 'Tortorella': [1237], 'D.': [1238, 1270, 4716], 'Goldberg': [1239], 'A.L.': [1240], 'Ploegh': [1241], 'H.': [1242, 2019], '94:': [1251], '6629-6634Crossref': [1252], '(408)': [1255], 'Scholar)': [1257, 1298, 2537, 5269], '(data': [1258, 2963], 'shown).': [1260, 2965, 3218, 4844], 'TheHindIII/EcoRI': [1261], 'pGEM4/p-Prl': [1264], '(13High': [1265], 'Görlich': [1269], 'Andersen': [1271], 'S.S.L.': [1272], 'Ashford': [1273], 'Giner': [1275], 'Hartmann': [1277], 'E.': [1278, 2256], 'Prehn': [1279], 'Brunner': [1285], '1993;': [1290, 1480], '268:': [1291, 1481], '26745-26751Abstract': [1292], 'coding': [1299, 1320, 1375, 1380, 1492, 1721, 1920, 3025, 3704], 'transferred': [1303], 'pGEM3Z': [1305], '(Promega)': [1306, 1503], 'under': [1307], 'control': [1309, 3402, 3567], 'SP6': [1312, 1334, 1392, 1466], 'promotor': [1313], 'give': [1315], 'pGEM3Z/p-Prl.': [1316], 'To': [1317, 1372, 1793, 1963, 2680, 2899, 2979, 3145, 3330, 3478, 3650, 3861], 'prepare': [1318, 1373], 'mRNA': [1319, 1374, 1491, 1720, 3024], 'full-length': [1322, 3495], 'p-Prl,': [1323, 4350], 'plasmid': [1324], 'pGEM3Z/p-Prl': [1325], 'linearized': [1327], 'withEcoRI': [1328], 'transcribed': [1330], 'RNA': [1335, 1467], 'polymerase': [1336, 1385, 1390, 1454, 1468], '42': [1338], '°C': [1339, 1636, 1731, 1864, 1898, 2208], 'presence': [1342, 3037, 3381, 3457, 3502, 3600], '500': [1344, 1541, 1598, 1624, 1629, 1695, 1762, 3512], 'μmm7G(5′)ppp(5′)G': [1345], 'CAP': [1346], 'analogue': [1347], '(New': [1348], 'England': [1349], 'Biolabs)': [1350], '(14Gilmore': [1351], 'Collins': [1353], 'Kellaris': [1357], 'Rapiejko': [1359], 'Methods': [1361, 1526], '1991;': [1364], '34:': [1365], '223-239Crossref': [1366], '(72)': [1369], 'p-Prl/86,': [1377], 'amplified': [1383], 'usingPfu': [1388], 'DNA': [1389, 1460], '(Stratagene),': [1391], 'primer,': [1393], 'reverse': [1396, 1446], 'primer': [1397, 1447], 'starting': [1398, 1448], '5′-end': [1401], 'triplet': [1404], 'corresponds': [1406], '86th': [1409], 'amino': [1410, 2389, 2417, 2445, 2668], 'residue.': [1412], 'When': [1413, 3534, 4104], 'translation': [1414, 1423, 2135, 3541], 'supposed': [1416], 'terminate': [1418], 'proper': [1420], 'termination': [1421], 'given': [1426, 4467], 'residue': [1427, 3688], '(e.g.': [1428], 'synthesis': [1430, 5209], 'reference': [1432, 1922, 3665, 3734], 'peptides),': [1433], 'TAG': [1435], 'stop': [1436], 'codon': [1437], 'relevant': [1442], 'position,': [1443], '5′-NNNNNNNNNCTA-': [1450], 'reaction.': [1456, 3886], 'Polymerase': [1457], 'reaction-amplified': [1459], 'transcribedin': [1463], 'above': [1471], '(15Nilsson': [1472], 'I.': [1473], 'von': [1474], 'Heijne': [1475, 4178], 'G.': [1476, 1525, 2015, 2045, 2246, 2254, 3906, 4042, 4179], '5798-5801Abstract': [1482], 'Translations': [1489, 1917], 'performed': [1496, 1931, 2694, 2909, 4152], '25': [1498, 1567, 1933], 'μl': [1499, 1538, 1568, 1675, 1696, 1705, 1734, 1753, 1782, 1797, 1813, 1854, 1934, 2132, 2143, 2165, 2173, 2191, 2274, 2311, 2336, 2343], 'reticulocyte': [1501, 1736, 3498], 'lysate': [1502, 1737, 3499], 'containing': [1504, 1561, 1738, 1939, 2072, 2278], '[35S]methionine': [1505, 1739, 1940], '(Amersham': [1506], 'Pharmacia': [1507], 'Biotech)': [1508], 'and,': [1509, 2602, 3427], 'indicated,': [1511, 2163], '1.5': [1512], 'eq': [1513], 'nuclease-treated': [1515, 1741], 'dog': [1520, 1975], 'pancreas': [1521, 1976], '(16Walter': [1522], 'Blobel': [1524, 2044, 3905, 4041], 'Enzymol.': [1527], '1983;': [1528], '84-93Crossref': [1530], '(480)': [1533], 'Scholar),': [1535, 2029, 3918], '(0.25': [1537, 1549], 'μm': [1542, 1816, 1820, 2168, 2962, 3213], 'stock': [1543], 'solution': [1544], 'Me2SO),': [1546], 'Me2SO': [1548, 1799, 2174], 'μl).': [1550], '°C.': [1559, 1846, 2126, 2356], 'next': [1564, 1870, 2060], 'diluted': [1565, 1750], 'RM': [1570, 1755, 1784], 'HEPES-KOH,': [1574], '7.6,': [1576, 2150], '50': [1577, 1674, 1733, 1752, 2073, 2078, 2287], 'potassium': [1579, 1600, 1626, 1764, 2080, 2153], 'acetate,': [1580, 1584, 2081, 2085, 2154, 2158], '2': [1581, 2082, 2131, 2155, 2190, 3191, 3992], 'magnesium': [1583, 2084, 2157], 'sucrose),': [1590], 'salt': [1593, 2011, 3514, 4021], 'concentration': [1594, 3237], 'raised': [1596], 'acetate.': [1601], 'After': [1602, 1746, 2204, 2727, 3358], 'incubation': [1603, 1861, 2205, 3123, 3139], 'ice,': [1608, 2103], 'membranes': [1609, 1886], 'separated': [1611, 1888, 2360, 3363], '3-min': [1614], 'centrifugation': [1615, 1690, 1769, 1892, 2111, 3370], '100-μl': [1618], 'sucrose': [1619, 1772, 3519], 'cushion': [1620, 1773, 3520], '(RM': [1621], 'acetate': [1627, 1765], 'mmsucrose)': [1630], '48,000': [1632], 'rpm': [1633, 1895, 2123], '4': [1635, 1897, 2125, 3435, 3554, 3573], 'Beckman': [1639, 1901], 'TLA100': [1640, 1902], 'rotor': [1641, 2115], '(4Lyko': [1642, 3624], 'supplemented': [1672, 2308], 'saturated': [1677], '(NH4)2SO4': [1678], 'precipitate': [1680, 1686, 2327], 'bulk': [1682], 'proteins.': [1684, 5346], 'recovered': [1688, 1767, 2329], 'washed': [1692, 2332], 'once': [1693], '5%': [1698], 'trichloroacetic': [1699, 1875, 2217, 2322], 'twice': [1702, 2333], '150': [1704, 2335], 'Membrane': [1708, 2268], 'pellets': [1711, 2269], 'below.': [1718, 1916], 'Truncated': [1719, 3023], 'p-Prl/86': [1723, 3043, 3072, 3089, 3101, 3354, 3969], 'translated': [1725, 3034, 3494, 3948], '10': [1727], '(3': [1744], 'eq).': [1745], 'translation,': [1747], 'buffer,': [1756, 1785, 3087], 'treated': [1760, 3346], 'above.': [1776, 4468], 'Microsomes': [1777, 3081, 3508], 'resuspended': [1779, 2061, 3085], '120': [1781], 'split': [1789], '20-μl': [1791], 'aliquots.': [1792], 'one': [1794, 3279, 3962, 4697], 'aliquot,': [1795], '0.5': [1796, 1812], 'added,': [1801, 1835], 'sample': [1804, 2096, 2276, 2345], 'placed': [1806], 'ice;': [1808], 'aliquots,': [1811], '40': [1815, 2167], '400': [1819], '20': [1823, 1828, 2352], 'mmcalpain': [1824], 'I,': [1826, 3228], 'dichloroisocoumarin': [1830, 3249], '(all': [1831], 'Me2SO)': [1833], 'pre-incubated': [1840], '3': [1842, 3127, 3141, 3188, 3209, 3239, 3265, 3740], '22': [1845, 1863], 'Nascent': [1847], 'chains': [1848, 3002, 3044, 3073, 3090, 3102, 3355, 3970], 'adding': [1852, 1874, 2216, 2321], '100': [1856, 2151, 2961], 'puromycin': [1858, 2306, 3125, 4017], '15': [1866], 'min.': [1867], 'Proteins': [1868, 2229, 2357], 'either': [1871, 2420, 2568, 2780], 'precipitated': [1872, 2214, 2319], '10%': [1878], '(see': [1883, 2137, 2227], 'below)': [1884], '10-min': [1891], '100,000': [1894], 'rotor,': [1903], 'pellet': [1907], 'supernatant': [1909, 3432], 'mRNAs': [1919, 3703], '(p-Prl/18,': [1924], 'p-Prl/20,': [1925], 'p-Prl/25,': [1926], 'p-Prl/27,': [1927], 'p-Prl/30)': [1929], 'wheat': [1936, 2313], 'germ': [1937, 2314], 'extract': [1938], '(17Martoglio': [1941, 1977], 'Hauser': [1943, 1979], 'Celis': [1947, 1983], 'Biology:': [1950, 1986], 'Laboratory': [1952, 1988], 'Handbook.': [1953, 1989], '2.': [1954, 1990], 'Academic': [1955, 1991], 'Press,': [1956, 1992], 'Inc.,': [1957, 1993], 'San': [1958, 1994], 'Diego,': [1959, 1995], 'CA1998:': [1960, 1996], '265-274Google': [1961, 1997], 'obtain': [1964], 'solubilized': [1965, 2271, 2340, 4094], 'proteins,': [1968, 4111], 'first': [1972, 2617, 4015], 'Associated': [1999], 'ribosomes': [2000, 3049, 4025], 'peripheral': [2002], 'removed': [2006, 2109], 'puromycin/high': [2010], '(18Hauser': [2012], 'Bacher': [2014], 'Lütcke': [2018], '14:': [2023], '5485-5493Crossref': [2024], '(50)': [2027], 'lumenal': [2031, 4037], 'depleted': [2034], 'exposure': [2036], 'alkaline': [2040], '(19Nicchitta': [2042, 4039], 'C.V.': [2043, 4040], 'Cell.': [2046, 3907, 4043, 4061, 4377, 4439, 4520, 4730, 4998], '1990;': [2047, 4044], '60:': [2048, 4045], '259-269Abstract': [2049, 4046], '(74)': [2055, 4052], 'Membranes': [2058], '(1–2': [2062], 'eq/μl)': [2063], 'Dounce': [2067], 'homogenizer': [2068], 'solubilization': [2070], 'Tris-HCl,': [2075], '7.8,': [2077], '125': [2086], 'sucrose,': [2088, 2291], '2%': [2093], 'CHAPS.': [2094, 4103], 'non-solubilized': [2105], 'subsequently': [2108], 'TLA100.4': [2114], '(Beckman': [2116], 'Instruments)': [2117], '75,000': [2122], 'For': [2127], 'assay,': [2130, 3967], 'p-Prl/30': [2134, 3919, 3949, 4083, 4105], 'mixture': [2136], 'above)': [2138], 'added': [2140, 2176, 2737, 3538], '35': [2142], 'assay': [2145, 2861, 2994, 3201, 3871, 5334], '(25': [2147], 'mmHEPES-KOH,': [2148], 'dithiothreitol).': [2161], 'Where': [2162], 'added;': [2171], 'all': [2178], 'samples.': [2181], 'started': [2185], '(2': [2192], 'eq)': [2193], 'microsomes,': [2196, 3954], 'puromycin-treated,': [2197], 'content-depleted': [2199], 'detergent-solubilized': [2202, 4110, 4201, 5343], 'microsomes.': [2203, 3040], 'h,': [2211], '10%,': [2220], 'below).': [2228], 'analyzed': [2233, 3372], 'Tris-Bicine': [2237], 'gels': [2238, 2369], '(20Wiltfang': [2239], 'Smirnov': [2241], 'Schnierstein': [2243], 'Kelemen': [2245], 'Matthies': [2247], 'Klafki': [2249], 'H.W.': [2250], 'Staufenbiel': [2251], 'Huther': [2253], 'Ruther': [2255], 'Kornhuber': [2257], 'Electrophoresis.': [2259], '18:': [2261], '527-532Crossref': [2262], '(122)': [2265], '12': [2273, 2342], '360': [2279], 'BisTris,': [2281], '160': [2282], 'bicine,': [2284], '1%': [2285], 'SDS,': [2286], '15%': [2290], '0.01%': [2292], 'bromphenol': [2293], 'blue,': [2294], '0.004%': [2296], 'Serva': [2297], 'blue.': [2298], 'Supernatants': [2299], '(20': [2300], 'μl)': [2301], 'obtained': [2302, 3136, 3564, 3698, 3956, 3963, 4139], 'extract,': [2315], '10%.': [2325], 'centrifugation,': [2331], 'acetone,': [2338], 'buffer.': [2346], 'All': [2347], '65': [2355], 'finally': [2359], '14.25%': [2362], 'acrylamide,': [2363], '0.75%': [2364], 'bis-acrylamide,': [2365], '8': [2366], 'm': [2367], 'urea': [2368], '(70': [2370], '×': [2371, 2373], '80': [2372], 'mm).': [2375], 'Labeled': [2376], 'visualized': [2379], 'STORM': [2382], 'PhosphorImager': [2383], '(Molecular': [2384], 'Dynamics).': [2385], 'Analysis': [2386], 'surrounding': [2392], 'putative': [2394, 2611, 4692], 'intra-membrane': [2395], 'cut': [2396, 4148, 5073], 'gp160': [2408], 'indicated': [2409, 2800], 'cluster': [2414], 'acids': [2418], 'scissile': [2424, 3831], 'amide': [2425], 'bond': [2426, 3833], 'A).': [2428, 3722], 'Based': [2429], 'information,': [2432], 'designed': [2434, 4818], 'central': [2440], 'electrophile': [2441, 2573], 'surrounded': [2442], 'aliphatic': [2444], 'residues.': [2447], 'Previously,': [2448], 'Veber': [2449, 2480, 2525], 'co-workers': [2451], '(21Marquis': [2452], 'R.W.': [2453, 2494], 'Yamashita': [2454, 2497], 'Ru': [2456, 2495], 'Y.': [2457, 2496], 'LoCastro': [2458], 'S.M.': [2459, 3904], 'Oh': [2460, 2499], 'H.J.': [2461, 2500], 'Erhard': [2462], 'K.F.': [2463], 'DesJarlais': [2464], 'R.L.': [2465], 'Head': [2466], 'M.S.': [2467, 2524, 4370, 4432, 4517, 4726, 4991], 'Smith': [2468, 2513], 'W.W.': [2469, 2514], 'Zhao': [2470, 2515], 'Janson': [2472, 2517], 'Abdel-Meguid': [2474, 2519], 'S.S.': [2475, 2520], 'Tomaszek': [2476, 2509], 'Levy': [2478, 2507], 'M.A.': [2479, 2508], 'D.F.': [2481, 2526], '41:': [2486], '3563-3567Crossref': [2487], '(56)': [2490, 2535], '22Marquis': [2493], 'Yen': [2501], 'Thompson': [2503], 'S.K.': [2504], 'Carr': [2505], 'T.J.': [2506], 'Ijames': [2511], 'C.F.': [2512], "D'Alessio": [2521], 'K.J.': [2522], 'McQueney': [2523], 'Bioorg.': [2527], '7:': [2531], '581-588Crossref': [2532], 'symmetrical': [2540, 2621], 'derivatives': [2542, 2812], 'served': [2543], 'potent': [2545, 2607], 'cathepsin': [2551], 'compounds': [2554, 2588, 2937, 2968], 'bind': [2555], 'enzyme': [2558, 2778], 'portions': [2563], 'occupy': [2574], 'prime': [2577], 'non-prime': [2579], 'sites.': [2581, 4949], 'reasoned': [2583], 'analogs': [2585], 'these': [2587, 2905, 2967, 5180], 'might': [2589, 2604], 'suited': [2592], 'mimicking': [2594], 'core': [2597], 'therefore,': [2603], 'serve': [2605], 'activity.': [2615, 2768, 2870], 'simple': [2620], 'di-leucine-containing': [2622], 'which': [2625, 2645, 4502, 4590, 4610, 4954, 5103], 'termini': [2628], 'capped': [2630], 'carboxybenzoyl': [2634], 'group': [2635, 2649, 2654, 4643], 'ketone;': [2637, 2677], 'Fig.': [2638], 'related': [2642, 5361], 'Z': [2647, 2688, 2809, 2831], 'capping': [2648], 'replaced': [2651], 'at-butoxycarbonyl': [2653], 'also': [2656, 3828, 4612, 4903], 'synthesized.': [2657], 'acid,': [2663], 'di-free': [2667], 'alkylated': [2673], '((Bio-LL)2': [2676], 'Fig.1': [2678], 'initially': [2681], 'determine': [2682, 3331, 3651], 'specificity': [2684], 'derivatives,': [2692, 2907], 'competition': [2695, 2914], 'experiments': [2696, 2915, 2927], 'crude': [2698], 'cellular': [2699, 4359], 'extracts.': [2700, 2740], 'Lysates': [2701], 'temperature': [2725], '(Fig.2).': [2726], 'pre-incubation,': [2728], 'radiolabeled': [2730], 'general': [2731, 2826, 2845], '125I-JPM-565': [2735], 'covalently': [2743], 'modifies': [2744], 'active': [2746, 2774, 2954, 4080], 'papain': [2752], 'family': [2753, 4749], 'proteases.': [2756, 2898, 4268, 5368], 'Intensity': [2757], 'labeling': [2759, 2792, 2838, 2851], 'targets': [2762], 'serves': [2763], 'readout': [2765, 2865], 'enzymatic': [2767], 'Thus,': [2769, 2966], 'prior': [2770], 'modification': [2771, 2950], 'observed': [2787, 2874], 'loss': [2790], '125I-JPM-565.': [2794], 'extracts': [2799, 2918], 'low': [2803, 2880], '(0.1–10': [2805], 'μm)': [2806], 'neither': [2807], 'nor': [2810], 'biotin-capped': [2811], 'reactive': [2814], 'any': [2816], 'multiple': [2819], 'targeted': [2823], 'label125I-JPM-565.': [2829], 'high': [2834, 2959], 'blocks': [2837], '25-kDa': [2842], 'polypeptide.': [2843], 'blocked': [2850], 'JPM-565-reactive': [2856], 'proteases,': [2857], 'indicating': [2858, 3742], 'effective': [2864], 'Therefore,': [2871], 'effects': [2873], 'likely': [2892, 3453, 4151], 'due': [2893, 3454], 'inhibition': [2895], 'establish': [2901], 'reactivity': [2903, 2933], 'set': [2912], 'label': [2922], 'readout.': [2925], 'provided': [2928, 4428], 'complementary': [2929], 'information': [2930], 'Both': [2941], 'showed': [2948], 'no': [2949, 3560, 4841], 'proteasomal': [2953], 'do': [2969], 'block': [2971], 'action': [2973], 'multicatalytic': [2976], 'complex.': [2978], 'investigate': [2980], 'previously': [2990], 'established': [2991, 4216], 'includes': [2996], 'synchronized': [2997], 'short': [3000, 3076, 3122], 'ER-derived': [3004, 3848], '86': [3028], 'residues': [3030, 3714, 3760], 'bound': [3046], 'C': [3052, 4567, 4575], 'terminus': [3053], 'inserted': [3055, 3972], 'translocons': [3058, 3975], 'via': [3059], 'sequence.': [3063], 'did': [3067], 'occur': [3069], 'because': [3070, 3676], 'too': [3075], '(Fig.3': [3077], 'A,': [3078, 3128, 3142, 3397, 3436, 3738], 'lane': [3079, 3129, 3143, 3241, 3267, 3398, 3437, 3556, 3575, 4090, 4126, 4144], '1).': [3080], 'ribosome': [3095], 'puromycin.': [3100, 3357], 'translocated,': [3104], 'cleaved': [3110, 3749, 3977, 4550, 4582, 4613, 4959], 'processed.': [3112], 'liberated,': [3114], '30-residue': [3115], 'seen': [3119], '(Fig.': [3126, 3140, 3187, 3208, 3238, 3264, 3434, 3553, 3572, 3720, 3736, 4141], '2),': [3130], 'whereas': [3131], 'longer': [3138], '3).': [3144, 3193, 3557, 3994], 'distinguish': [3146], 'individual': [3148], 'steps': [3150], 'processing,': [3158], 'tested': [3160], 'several': [3161], 'classes': [3163], 'inhibitors.': [3166, 4809], 'B,': [3189, 3240, 3266, 3555, 3574, 3990, 4089, 4125, 4143], 'lanes': [3190, 3739, 3991], 'apparent': [3195], 'IC50': [3196], 'value': [3197], 'our': [3200], '∼50': [3203], 'nm': [3204], 'C)': [3210], '1–2': [3212], '(not': [3217, 4843], 'Similarly,': [3219], 'calpain': [3226], 'another': [3229, 4856], 'albeit': [3233], 'much': [3235], 'higher': [3236], '4).': [3242, 3438, 4091], 'contrast,': [3244, 3559, 4579], 'serine': [3246, 3761], 'peptidase,': [3252, 5328], 'blocking': [3254], '5).': [3268, 3399, 4127], 'indicate': [3271, 4193], 'least': [3278, 4457], 'reported': [3289, 4343], 'cytosolin': [3303], 'vitro,': [3304], 'it': [3306, 4112], 'upon': [3310, 4495, 5098], 'whether': [3332, 3480], 'required': [3335, 3485, 3588], 'before': [3351, 3981], 'puromycin,': [3361], 'fraction': [3377, 3395, 3433, 3552], 'separately.': [3378], 'unprocessed': [3386, 3544], 'exclusively': [3391], '(Fig.4': [3396], 'omitted,': [3408], 'cytosolic': [3425, 3524, 3901, 4489, 4554], 'hence,': [3428], 'Cytosol': [3439], 'membrane,': [3451, 4341, 4486, 5102, 5185], 'its': [3459, 3621, 3690, 3754, 4587], 'target,': [3460], 'calmodulin': [3461], 'test': [3479], 'efficient': [3487, 3590, 4813], 'portion,': [3492, 3596], 'extracted': [3510, 4012], 'sedimented': [3516], 'remove': [3522, 4023], 'interfere': [3527], 'small': [3532], 'mixture,': [3542], '2).': [3576], 'even': [3597], 'thought': [3608, 3814], 'between': [3615], 'leucine': [3618], 'clusters': [3619], 'site,': [3654], 'compared': [3656], 'electrophoretic': [3658], 'mobility': [3659, 3727], 'detected': [3670], 'must': [3671], 'represent': [3672], 'fragment,': [3675, 4118], 'radioactively': [3682], 'methionine': [3687], 'terminus.': [3692], 'Reference': [3693], 'easily': [3697], 'translating': [3702], '18-,': [3708], '20-,': [3709], '25-,': [3710], '30-amino': [3712], 'had': [3726], 'identical': [3728, 3959], '20-residue': [3733], 'and4),': [3741], 'region,': [3756, 4589, 4765], 'polar': [3759], 'asparagine': [3763], 'interrupt': [3764], 'segment.': [3767], 'Interestingly,': [3768], 'common': [3770], 'feature': [3771, 4757], 'acquisition': [3781], 'helix-break-helix': [3784], 'structure': [3785, 3812], 'apolar': [3788], 'environment': [3789], '(23van': [3790], 'Klompenburg': [3791], 'W.': [3792], 'de': [3793], 'Kruijff': [3794], 'Membr.': [3797], '162:': [3800], '1-7Crossref': [3801], '(43)': [3804], 'break': [3808], 'helix': [3811], 'facilitate': [3816, 5319], 'initial': [3821, 3997], 'phase': [3822], 'translocation': [3825], 'make': [3829], 'accessible': [3834], 'processing.': [3840, 4285], 'investigation': [3842], 'targeting,': [3855], 'translocation,': [3856], 'cleavage.': [3860], 'analyze': [3862], 'independently': [3864], 'preceding': [3866], 'reactions,': [3867], 'simplified': [3869], '(p-Prl/30)': [3878], 'immediate': [3881, 4250], 'Because': [3887], 'synthetic': [3888], 'enter': [3894, 3923], 'aid': [3899], 'components': [3902, 4319], '(24Simon': [3903], '1992;': [3908], '69:': [3909], '677-684Abstract': [3910], '(170)': [3916], 'expected': [3921, 4822], 'similarly': [3929, 5358], 'enters': [3935], 'conventional': [3940], 'pathway.': [3943], 'Indeed,': [3944], 'when': [3945, 4157], 'together': [3952], 'previous': [3966], 'could': [3986, 5175], '(Fig.5': [3989, 4088, 4124], 'attempt': [3998], 'catalyzes': [4004, 4694], '600': [4019], 'peripherally': [4027], 'alkali': [4033], 'wash': [4035], 'out': [4036], '25Hamman': [4055], 'B.D.': [4056], 'Hendershot': [4057], 'L.M.': [4058], '92:': [4063], '747-758Abstract': [4064], '(349)': [4072], 'PKXRMs': [4077], 'still': [4079], '∼20-residue': [4086, 4117], 'residual': [4096], 'detergent': [4102], 'intact,': [4121], 'untreated': [4122], 'reaction,': [4133], 'although': [4134, 4418], '∼27-residue': [4136], '7).': [4145], 'latter': [4147, 4596], 'that,': [4156], 'solubilized,': [4158], 'access': [4161], 'second': [4164], 'potential': [4165], 'consensus': [4166], 'C-terminal': [4170], 'extension': [4171], '(26von': [4177], 'Mol.': [4181, 4729], '1985;': [4183], '184:': [4184], '99-105Crossref': [4185], '(1540)': [4188], '"intramembrane': [4195], 'proteolysis"': [4196], 're-constituted': [4199], 'membranes.': [4202], '(27Stroud': [4217], 'R.M.': [4218], 'Walter': [4219], 'Curr.': [4221], 'Opin.': [4222], 'Struct.': [4223], '9:': [4226], '754-759Crossref': [4227], '(79)': [4230], 'beyond': [4238, 5146], 'pre-protein,': [4242], 'however,': [4243], 'remains': [4244, 4887], 'unclear.': [4245], 'Degradation': [4246], 'destination': [4251], 'cleared': [4258, 4306], 'unidentified': [4267, 4850], 'some': [4271], 'cases': [4272], 'shown': [4277, 5187], 'perform': [4279, 4647], 'downstream': [4281], 'Dissecting': [4286], 'pathway': [4288], 'presented': [4294, 5353], 'here,': [4295], 'reveals': [4296], 'possible': [4298], 'mechanism': [4299], 'how': [4301], 'indicates': [4310], 'approach': [4312, 5348], 'identification': [4315, 4882, 5322], 'process.': [4324], 'Cleavage': [4325], 'concomitant': [4332, 4897], 'become': [4352], 'increasingly': [4353], 'evident': [4354], 'differentiation,': [4360], 'lipid': [4361, 4416, 4868], 'metabolism,': [4362], 'presumably,': [4364], 'unfolded': [4366], 'response': [4368, 5274], '(28Brown': [4369, 4431, 4990], 'Ye': [4371, 4433, 4717, 4992], 'Rawson': [4373, 4435, 4994], 'R.B.': [4374, 4436, 4712, 4995], 'Goldstein': [4375, 4437, 4518, 4727, 4996], 'J.L.': [4376, 4438, 4519, 4728, 4997], '2000;': [4378, 4440, 4999], '100:': [4379, 4441, 5000], '391-398Abstract': [4380, 4442, 5001], '(1151)': [4388, 4450, 5009], '29Martoglio': [4391], 'Protoplasma.': [4393, 4665, 4872], '207:': [4395, 4667, 4874], '141-146Crossref': [4396, 4668, 4875], '(6)': [4398, 4670, 4877], 'named': [4404], 'proteolysis,': [4406], 'assuming': [4407], 'plain': [4413], 'bilayer,': [4417], 'proof': [4420], 'so': [4429, 4689], 'far': [4430], 'animal': [4454], 'three': [4458], 'undergo': [4460], 'according': [4463, 4819], 'definition': [4466], 'SREBPs': [4472, 4546, 4704], '(sterol': [4473], 'proteins)': [4476], 'Notch,': [4478], 'Golgi/plasma': [4485], 'respectively,': [4487], 'whose': [4488], 'transcription': [4490], 'factor': [4491], 'activation,': [4496], 'APP': [4498, 4580], '(β-amyloid': [4499], 'protein),': [4501], 'Aβ': [4510], 'suspected': [4511], 'cause': [4513], "Alzheimer's": [4514], 'disease': [4515], '(30Brown': [4516], '89:': [4522], '331-340Abstract': [4523], '(3029)': [4531], '31Selkoe': [4534], 'D.J.': [4535], '399': [4538], 'Suppl.': [4539], '6738:': [4540], 'A23-A31Crossref': [4541], '(1534)': [4543], 'Notch': [4548], 'close': [4551], 'end': [4555], 'II': [4563], 'topology': [4564, 4572], '(N': [4565, 4573], 'in,': [4566], 'out)': [4568], 'out,': [4574], 'in),': [4576], 'respectively.': 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[4834], 'mm)': [4835, 4839], 'o-phenanthroline': [4837], '(≤5': [4838], 'effect': [4842], 'belongs': [4854], 'presumably': [4862], 'plane': [4865], 'bilayer': [4869], 'molecular': [4881], 'challenging': [4889], 'task': [4890], 'future': [4892], 'research.': [4893], 'Intramembrane': [4894], 'bacteria.': [4906], 'eubacterium': [4908], 'Enterococcus': [4909], 'faecalis': [4910], 'secretes': [4911], 'octapeptide': [4913], 'pheromone': [4914, 4938], 'cAF1': [4915, 5032], '(33An': [4923, 5275], 'F.Y.': [4924, 5013, 5276], 'Sulavik': [4925, 5014, 5277], 'M.C.': [4926, 5015, 5278], 'Clewell': [4927, 5016, 5279], 'D.B.': [4928, 5017, 5280], '181:': [4932, 5021, 5284], '5915-5921Crossref': [4933, 5022, 5285], 'cleavages': [4946], 'First': [4950], 'contains': [4955], 'octapeptide,': [4957], 'off': [4960], 'extracellular': [4966], 'plasma': [4970], 'Then': [4972], 'designated': [4984], 'Eep': [4986], 'resembles': [4988], 'S2P': [4989], '33An': [5012], 'processes': [5027], 'SREBP': [5029], 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'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2025-01-12T19:33:42.524485', 'created_date': '2016-06-24'}