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'Mass.': [68, 105], 'Search': [69, 106], 'for': [70, 107, 339, 349, 422, 516, 655, 678, 764, 771, 820, 843, 879, 1028, 1316, 1328, 1388, 1407, 1438, 1476, 1623, 2008], 'more': [71, 108, 166, 420, 900], 'papers': [72, 109], 'by': [73, 110, 130, 177, 242, 450, 493, 504, 935, 951, 960, 1012, 1023, 1034, 1054, 1175, 1195, 1217, 1239, 1483, 1522, 1548, 1801, 2035], 'this': [74, 111, 520, 679, 920, 1358, 1664], 'author': [75, 112], 'KellyRalph': [79], 'Originally': [113, 2190], 'published2': [114], 'Feb': [115], '2001https://doi.org/10.1161/01.RES.88.2.129Circulation': [116], 'Research.': [117], '2001;88:129–131It': [118], 'is': [119, 152, 215, 434, 526, 762, 954, 1009, 1266, 1345, 1543], 'now': [120], 'established': [121], 'that': [122, 230, 235, 297, 329, 399, 411, 535, 686, 716, 748, 774, 882, 929, 939, 955, 971, 999, 1047, 1072, 1094, 1350, 1450, 1538, 1553, 1576, 1586, 1648], 'specialized': [123], 'plasmalemmal': [124, 155, 192, 841, 1058, 1253, 1259, 1298, 1614, 1974, 2031], 'lipid': [125, 128, 144, 1207, 1248], 'microenvironments,': [126], 'termed': [127, 157], 'rafts': [129, 145, 1208, 1710], 'Simons': [131, 1705], 'Toomre,1': [133], 'take': [134], 'part': [135], 'in': [136, 154, 180, 198, 206, 239, 281, 289, 311, 335, 362, 386, 393, 476, 500, 523, 530, 554, 575, 580, 618, 626, 640, 647, 650, 657, 689, 692, 700, 717, 722, 733, 739, 751, 783, 804, 827, 855, 1001, 1041, 1057, 1079, 1084, 1097, 1118, 1130, 1180, 1226, 1274, 1455, 1459, 1467, 1494, 1505, 1536, 1591, 1654, 1663, 1868, 1912, 1915, 1937, 2004, 2043, 2072, 2102, 2131], 'various': [137, 390], 'signal': [138, 240, 1642, 1712, 1749, 2045, 2068], 'transduction': [139, 241, 2085], 'processes.': [140], 'One': [141], 'subset': [142], '(which': [146], 'contain': [147, 429], 'mostly': [148], 'cholesterol': [149, 502, 510, 785], 'sphingolipids)': [151], 'found': [153, 1284], 'vesicles': [156, 193], 'caveolae.': [158, 1042, 1065], 'The': [159, 265, 514, 947, 1043, 1720, 1841], 'term': [160], 'caveolae': [161, 236, 497, 752, 842, 1254, 1293, 1329, 1615, 1721, 1870, 1975], '(“little': [162], 'caves”)': [163], 'was': [164, 473, 727, 1095, 1282, 1383, 1392], 'introduced': [165, 1479], 'than': [167, 912], '40': [168], 'years': [169], 'ago': [170], 'describe': [172], 'plasma': [173], 'membrane': [174, 1338, 1722], 'invaginations': [175], 'identified': [176, 492], 'electron': [178, 602], 'microscopy': [179], 'a': [181, 340, 355, 403, 412, 477, 527, 687, 697, 720, 731, 801, 810, 899, 936, 1055, 1080, 1326, 1370, 1433, 1456, 1503, 1619], 'wide': [182], 'variety': [183], 'cell': [185, 565, 776], 'types.': [186], 'Originally,': [187], 'these': [188, 282, 300, 389, 830, 952, 1583], '50-': [189], '100-nm': [191], 'were': [194], 'shown': [195, 631], 'participate': [197, 280, 334, 499], 'transcellular': [200], 'transport': [201, 503, 1060], 'macromolecules': [203], '(transcytosis)': [204], 'uptake': [208], 'small': [210, 578], 'molecules': [211], '(potocytosis).2': [212], 'However,': [213, 288, 1066], 'it': [214, 231, 1391], 'only': [216, 348], 'recently,': [217], 'with': [218, 417, 696, 729, 809, 995, 1124, 1149, 1347, 1526, 1578, 1606, 1873, 1908], 'identification': [220, 266], 'caveolins': [222, 324, 346, 451, 905, 1190], 'as': [223, 250, 257, 259, 303, 870, 990, 1236, 1325, 1410, 1575], 'structural': [225, 1824], 'coat': [226], 'component': [227, 549], 'caveolae,': [229, 797], 'has': [232, 744, 1191, 1609], 'been': [233, 331, 630, 746, 1192, 1610], 'recognized': [234], 'are': [237, 1404, 1643, 1666], 'involved': [238], 'ensuring': [243], 'compartmentation': [245], 'signaling': [247, 304, 391, 449, 931, 959, 1049, 1132, 1375, 2133], 'molecules,': [248], 'such': [249, 268, 869, 989], 'G': [251], 'protein': [252, 371, 414, 611], 'tyrosine': [254], 'kinase–associated': [255], 'receptors,': [256, 994], 'well': [258, 1193], 'endothelial': [260, 481, 555, 641, 651, 775, 973, 1596, 1808, 1842, 1864, 1902, 1969, 2000], 'nitric': [261, 1765, 1798, 1809, 1865, 1903, 2161], 'oxide': [262, 1766, 1799, 1810, 1866, 1904, 2066, 2162], 'synthase': [263, 1867, 1905, 1971], '(eNOS).': [264], 'distinct': [269], 'roles': [270], 'raises': [271], 'question': [273], 'how': [275], 'same': [277, 1311, 1573], 'organelle': [278], 'can': [279, 932, 1051, 1430], 'apparently': [283, 1403, 1645], 'quite': [284], 'different': [285], 'functions': [286, 301], 'simultaneously.': [287], 'case': [291, 1496], 'eNOS,': [293], 'recent': [294], 'data': [295, 671, 831, 1112, 1158], 'suggest': [296], 'both': [298, 321, 730, 792, 1301], '(ie,': [302], 'platforms': [305], 'intracellular': [307, 581, 757, 1005, 1131, 1621], 'trafficking': [308, 511, 1244], 'modules)': [309], 'are,': [310], 'fact,': [312], 'intimately': [313], 'related': [314, 1223], 'complementary.Repressing': [316], 'Basal': [317], 'Activity': [318], 'eNOSAlthough': [320], 'have': [325, 330, 629, 1448], 'several': [326, 424], 'consensus': [327], 'sequences': [328], 'proposed': [332, 1611], 'protein-protein': [336], 'interactions,': [337], 'evidence': [338, 436, 743, 1071], 'functional': [341, 444, 845, 1128, 1826], 'association': [342], 'between': [343, 538, 865], 'exists': [347], 'caveolin': [351, 377, 506, 524, 542, 595, 639, 648, 701, 795, 866, 883, 945, 1092, 1123, 1139, 1160, 1231, 1246, 1306, 1452, 1492, 1529, 1608, 1806, 1875, 1910], 'scaffolding': [352, 374, 2158], 'domain': [353, 375, 2159], '(CSD),': [354], 'juxtamembrane': [356], 'region': [357], '20': [359], 'amino': [360], 'acids': [361], 'C-terminal': [364], 'moiety': [365], 'caveolin.4': [367], 'Like': [368], 'other': [369, 674, 756], 'modular': [370], 'domains,': [372, 431, 1747], 'facilitates': [378], 'generation': [380], 'preassembled': [382], 'oligomeric': [383, 1120], 'proteins': [384, 392], 'and,': [385], 'addition,': [387, 615, 711], 'maintains': [388], 'their': [394, 967, 1098], 'off': [395], 'state.234': [396], 'Note,': [397], 'however,': [398, 857], 'presence': [401, 588], 'CSD': [404, 1474, 1528, 1549, 1557, 1589], 'consensus–binding': [405], 'sequence': [406], 'does': [407], 'not': [408, 892, 1039, 1163, 1393, 1667], 'necessarily': [409, 1668], 'imply': [410], 'given': [413], 'will': [415], 'interact': [416], 'one': [418], 'or': [419, 443, 570, 624, 659, 910, 975, 992, 1036, 1595, 1673], 'caveolins;': [421], 'example,': [423, 772, 880, 1029, 1317, 1477], 'toll-like': [427, 447], 'receptors': [428, 868, 1035, 2128], 'CSD-binding': [430], 'but': [432, 891], 'there': [433], 'no': [435, 1070], 'date': [438], 'either': [440, 1592], 'caveolar': [441, 467, 784, 816, 958, 986, 1210, 1302, 1408, 1426, 2123], 'targeting': [442, 468, 2025], 'regulation': [445, 1514, 2011], 'receptor': [448, 874, 908, 1355, 2029], '(S.': [452], 'Franz,': [453], 'T.': [454, 1759, 1840, 1996, 2023], 'Bourcier,': [455], 'R.A.': [456], 'Kelly,': [457], 'unpublished': [458], 'observations).The': [459], 'physiological': [460], 'relevance': [461], 'inhibitory': [464, 708, 863, 902, 1488], 'interaction': [465, 558, 1804, 2003], 'on': [469, 479, 906, 913, 1141, 1233, 1400, 1508], 'basal': [470, 531, 548, 893, 1632], 'NO': [471, 532, 552, 574, 663, 766, 896, 956, 980, 1024, 1048, 1074, 1085, 1099, 1142, 1174, 1374, 1461, 2132], 'production': [472, 1507, 1800], 'recently': [474, 684, 1237, 1283], 'provided': [475, 747, 1113], 'study': [478, 812], 'intact': [480], 'cells': [482, 652, 974, 978, 1468, 1597], 'exposed': [483], 'high': [485, 1015, 1185], 'levels': [486], 'LDL': [488], 'cholesterol.5': [489], 'As': [490], 'originally': [491], 'Fielding': [494, 1817, 1819], 'Fielding,6': [496], 'also': [498, 745, 1045, 1105, 1318, 1356, 1405], 'reverse': [501], 'increasing': [505, 1451], 'abundance': [507, 525, 649, 702, 735, 1183, 1453], 'promote': [509, 633, 1286], 'efflux.': [513], 'consequence': [515], 'function': [518, 1205], 'cholesterol-induced': [521], 'increase': [522, 646, 699, 738, 1083], 'marked': [528, 698, 802, 1457], 'decline': [529, 803, 1458], 'release,': [533], 'suggesting': [534, 898], 'equilibrium': [537], 'bound': [540], 'caveolin-free': [544], 'determines': [546], 'eNOS-dependent': [551, 930, 1600], 'release': [553, 1003, 1018, 1172], 'cells.': [556, 642], 'This': [557, 850, 1007, 1344], 'may': [559, 1162, 1221, 1250], 'be': [560, 853, 933, 1052, 1106, 1164, 1222, 1309, 1386, 1431, 1520, 1618, 1651], 'required': [561, 1406], 'protect': [563], 'from': [566, 638, 672, 796, 1004, 1257, 1296, 1335, 1470, 1973], 'undesired,': [567], 'potentially': [568, 1010], 'cytotoxic,': [569], 'nonphysiological': [571], 'bursts': [572], 'response': [576], 'fluctuations': [579], 'calcium': [582, 1002], '([Ca2+]i).Promoting': [583], 'Stimulation': [584], 'eNOSIn': [586], 'increased': [590], '[Ca2+]i,': [591], 'calmodulin': [592, 1878], 'binding': [593, 607, 1402, 1911], 'antagonizes': [596], 'blockade': [598], '(or': [599], 'slowing)': [600], 'transfer': [603], 'attributable': [604, 620], 'scaffold': [610], 'eNOS.4': [613], 'In': [614, 665, 710, 966, 1860, 2152], 'transient': [616], 'increases': [617, 625], '[Ca2+]i': [619, 1031], 'agonist': [622, 658, 1234, 1509, 1513], 'activation7': [623], 'vascular': [627, 1569], 'flow8': [628], 'dissociation': [635, 1876], 'Therefore,': [643, 1300], 'conversely,': [644], 'an': [645, 737, 1270, 1579], 'could': [653, 1308, 1519], 'account': [654], 'alterations': [656, 1129, 1225], 'flow-mediated': [660], 'stimulation': [661, 824], 'production.': [664], 'addition': [666], 'hypercholesterolemia,': [668], 'mentioned': [669], 'above,5': [670], '2': [673, 1446], 'studies': [675, 1447, 1584], 'provide': [676, 1069], 'support': [677], 'hypothesis.': [680], 'Shah': [681, 1885], 'et': [682, 713, 769, 926, 1219, 1314, 1533], 'al9': [683], 'reported': [685, 773, 881, 1449], 'decrease': [688, 721, 732, 1056, 1179, 1504], 'perfusion': [690], 'pressure': [691], 'cirrhotic': [693], 'liver': [694], 'correlated': [695], 'stabilization': [704], 'caveolin/eNOS': [707], 'complex.': [709], 'Pelligrino': [712, 1921], 'al10': [714], 'documented': [715, 1194, 1384], 'ovariectomized': [718], 'rats,': [719], 'acetylcholine-induced': [723, 805], 'pial': [724, 1934], 'arteriolar': [725, 1935], 'vasodilation': [726], 'associated': [728, 1907], 'caveolin-1': [740, 2042, 2074, 2157], 'abundance.Importantly,': [741], 'persuasive': [742], 'localization': [750, 839], 'per': [753, 916], 'se': [754], '(versus': [755], 'locales': [758], 'enzyme)': [761], 'key': [763, 835], 'agonist-stimulated': [765, 1460], 'release.': [767], 'Blair': [768, 1954], 'al,11': [770], 'exposure': [777, 1144, 1340, 1377], 'oxidized': [779], 'LDL,': [780], 'which': [781, 1026, 1076, 1265, 1607], 'results': [782, 1078], 'depletion,': [786], 'rapidly': [787], 'caused': [788], 'translocation': [790, 1334], 'thereby': [798, 1367], 'leading': [799, 1368], 'activation.': [807, 1979, 2088], 'Together': [808], 'previous': [811], 'documenting': [813, 1159], 'obligatory': [815], 'location': [817, 1418, 1427], 'muscarinic': [822, 1353, 1379, 1512, 2126], 'cholinergic': [823, 2127, 2197], 'cardiac': [828, 1481, 1498, 1593, 2005], 'myocytes,12': [829], 'point': [832], 'role': [836, 1273, 2040, 2071], 'within': [840, 1292, 1423], 'its': [844, 1332, 1626], 'coupling': [846, 911, 984], 'specific': [848], 'agonists.': [849, 1380], 'paradigm': [851], 'must': [852], 'modified': [854], 'part,': [856], 'because': [858], 'known': [861, 1267], 'direct': [862], 'interactions': [864], 'sphingosine': [872, 887, 2036], '1-phosphate': [873, 2037], 'EDG-1.13': [875], 'Igarashi': [876, 2020], 'Michel,13': [878], 'overexpression': [884], 'markedly': [885], 'attenuates': [886, 2067], '1-phosphate–mediated': [888], 'activation': [890, 909, 1525, 2034], 'rates': [894], 'production,': [897, 1075, 1086], 'proximal': [901], 'effect': [903], 'EDG-1': [907, 2028], 'activity': [915, 1168, 1540, 1906], 'se.Terminating': [917], 'SignalingIn': [919], 'issue': [921], 'Circulation': [923], 'Research,': [924], 'Li': [925, 1218, 1313, 2052], 'al14': [927, 1220], 'propose': [928, 1046], 'terminated': [934, 1053], 'NO/cGMP-dependent': [937], 'process': [938, 1276], 'leads': [940, 1087], 'disruption': [943, 1063], 'oligomers.': [946], 'hypothesis': [948], 'put': [949], 'forward': [950], 'authors': [953, 1044, 1068], 'disrupts': [957], 'distancing': [961], 'elements': [962], 'cascade.': [965], 'study,': [968], 'they': [969], 'document': [970], 'exposing': [972], 'smooth': [976], 'muscle': [977], 'donors': [981], 'alters': [982], 'resident': [987], 'proteins,': [988], 'bradykinin': [991], 'endothelin': [993], 'downstream': [996, 1373], 'signal-transduction': [997], 'cascades': [998], 'result': [1000], 'stores.': [1006], 'interpretation': [1008], 'confounded': [1011], 'relatively': [1014], 'noncompartmentalized': [1017], 'concentrations': [1020], 'NOx': [1022], 'donors,': [1025], 'could,': [1027], 'affect': [1030], 'transients': [1032], 'induced': [1033], 'ion': [1037], 'channels': [1038], 'located': [1040], 'itself': [1050], 'L-arginine': [1059], 'through': [1061, 1279, 1364], 'NO-mediated': [1062], 'L-arginine–induced': [1073], 'presumably': [1077], 'physiologically': [1081], 'relevant': [1082, 1165], 'degree': [1090], 'redistribution': [1093], 'observed': [1096, 1216, 1466, 1577], 'donor': [1100, 1143], 'experiments.': [1101], 'Other': [1102], 'caveats': [1103], 'should': [1104], 'noted.': [1107], 'First,': [1108], 'none': [1109], 'causally': [1114], 'associates': [1115], 'change': [1117], 'status': [1121], 'any': [1125], 'tested.': [1133], 'Second,': [1134], 'proportion': [1136], 'disrupted': [1138], 'complexes': [1140, 1188], 'remains': [1145, 1414], 'limited': [1146], 'when': [1147, 1478], 'compared': [1148], 'total': [1151], 'cellular': [1152], 'pool': [1153, 1441], 'caveolins.': [1155], 'Third,': [1156], 'deoligomerization': [1161, 1307], 'physiological,': [1170], 'compartmentalized': [1171], 'eNOS.Nevertheless,': [1176], 'NO/cGMP-evoked': [1178], 'relative': [1182], 'molecular': [1186, 1762], 'weight': [1187], 'independent': [1196], 'methodological': [1197], 'approaches': [1198], 'certainly': [1200], 'emphasizes': [1201], 'plasticity': [1203], 'microdomains.': [1211], 'Accordingly,': [1212], 'biophysical': [1214], 'changes': [1215], 'detergent': [1227], 'solubility': [1228], 'heterocomplex': [1232], 'stimulation,': [1235, 1637], 'reviewed': [1238], 'Fleming': [1240, 2080], 'Busse.15': [1242], 'Intracellular': [1243], 'microdomains': [1249], 'correspond': [1251], 'after': [1255, 1294, 1339, 1376], 'budding': [1256, 1295], 'membrane.': [1260], 'Indeed,': [1261, 1445], 'GTPase': [1263], 'dynamin,': [1264], 'play': [1269], 'essential': [1271], 'regulatory': [1272, 1845], 'endocytosis': [1278], 'clathrin-coated': [1280], 'pits,': [1281], 'cholera': [1287, 1321], 'toxin': [1288, 1322], 'B': [1289, 1323], 'chain': [1290], 'internalization': [1291, 1363], 'membrane.16': [1299], 'fission': [1303], 'apparent': [1305], 'phenomenon.': [1312], 'al,14': [1315], 'used': [1319], 'subunit': [1324], 'marker': [1327], 'demonstrated': [1331], 'reversible': [1333, 1484], 'plasma-lemmal': [1337], 'sodium': [1342], 'nitroprusside.': [1343], 'consistent': [1346], 'observation': [1349], 'M2': [1352], 'acetylcholine': [1354], 'follows': [1357], 'mode': [1359], 'sequestration': [1361, 2124], 'budded': [1365], 'caveolae,17': [1366], 'desensitization': [1371], 'Although': [1381], 'dynamin': [1382, 2101], 'necessary': [1387], 'caveolar-plasmalemmal': [1389], 'fission,': [1390], 'sufficient.': [1394], 'Additional,': [1395], 'presently': [1396], 'unidentified': [1397], 'mechanisms': [1398], 'dependent': [1399], 'agonist-receptor': [1401], 'budding.Caveolae': [1409], 'OrganellesAlthough': [1412], 'controversy': [1413], 'regarding': [1415], 'subcellular': [1417], 'all': [1420], 'moieties': [1422], 'cells,': [1424], 'considered': [1432], 'major': [1434], 'locale,': [1435], 'at': [1436], 'least': [1437], 'activatable': [1440], 'enzyme.': [1444], 'resulted': [1454], 'generation,': [1462], 'mimicking': [1463], 'phenotype': [1465], 'isolated': [1469], 'knockout': [1472], 'animals.': [1473], 'peptides,': [1475], 'into': [1480], 'myocytes': [1482, 1594], 'permeabilization,': [1485], 'mimic': [1486], 'effects': [1489, 1941], 'full-length': [1491], '(caveolin-3': [1493], 'myocytes)': [1499], 'lead': [1501], 'cGMP': [1506], 'stimulation.12': [1510], 'Moreover,': [1511], 'myocyte': [1516], 'beating': [1517], 'rate': [1518], 'inhibited': [1521], 'suppressing': [1523], '20-residue': [1527], 'surrogates.': [1530], 'Recently,': [1531], 'Bucci': [1532, 2138], 'al18': [1534], 'confirmed': [1535], 'mice': [1537], 'highly': [1544], 'sensitive': [1545], 'inhibition': [1547], 'peptides.': [1550], 'They': [1551], 'showed': [1552], 'systemic': [1554], 'administration': [1555], 'peptides': [1558, 1590], '(fused': [1559], 'homeodomain': [1562], 'antennapedia)': [1564], 'suppressed': [1565], 'acute': [1566], 'inflammation': [1567], 'leak': [1570], 'extent': [1574], 'NOS': [1580], 'inhibitor.': [1581], 'Together,': [1582], 'demonstrate': [1585], 'expression': [1587], 'clearly': [1598], 'targets': [1599, 1605], 'signaling.Considering': [1601], 'many': [1603], 'potential': [1604], 'interact,': [1613], 'seem': [1616, 1649], 'well-suited': [1620], 'locale': [1622], 'complex': [1627], 'regulation.': [1628], 'Tonic': [1629], 'repression': [1630], 'activity,': [1633], 'facilitation': [1634], 'agonist-evoked': [1636], 'termination': [1639], '3': [1644], 'paradoxical': [1646], 'tasks': [1647], 'effectively': [1652], 'managed': [1653], 'context': [1656], 'caveolar/eNOS': [1659], 'interaction.The': [1660], 'opinions': [1661], 'expressed': [1662], 'editorial': [1665], 'those': [1669], 'editors': [1672], 'American': [1676, 2186], 'Heart': [1677, 2187], 'Association.FootnotesCorrespondence': [1678], 'Feron,': [1681], 'Unit,': [1690], 'UCL-FATH': [1691], '5349,': [1692], '53,': [1693], 'Avenue': [1694], 'E.': [1695], 'Mounier,': [1696], 'B-1200': [1697], 'Belgium.': [1699], 'E-mail': [1700], '[email': [1701], 'protected]': [1702], 'References': [1703], '1': [1704], 'K,': [1706, 1896], 'Toomre': [1707], 'D.': [1708], 'Lipid': [1709], 'transduction.': [1713, 1750, 2046], 'Nat': [1714, 2167], 'Rev.2000;': [1715], '1:31–39.Google': [1716], 'Scholar2': [1717], 'Anderson': [1718], 'RG.': [1719], 'system.': [1723], 'Annu': [1724], 'Rev': [1725], 'Biochem.1998;': [1726], '67:199–225.CrossrefMedlineGoogle': [1727], 'Scholar3': [1728], 'Smart': [1729, 1962], 'EJ,': [1730], 'Graf': [1731], 'GA,': [1732], 'McNiven': [1733, 2097], 'MA,': [1734, 1992], 'Sessa': [1735, 1897, 2150], 'WC,': [1736, 1898], 'Engelman': [1737], 'JA,': [1738, 1772], 'Scherer': [1739], 'PE,': [1740], 'Okamoto': [1741], 'T,': [1742], 'Lisanti': [1743], 'MP.': [1744], 'Caveolins,': [1745], 'liquid-ordered': [1746], 'Mol': [1751], 'Cell': [1752, 1760], 'Biol.1999;': [1753], '19:7289–7304.CrossrefMedlineGoogle': [1754], 'Scholar4': [1755], 'O,': [1757, 1787, 1834, 1986], 'Michel': [1758, 1837, 1839, 1995, 2022], 'biology': [1763], 'synthases.': [1767], 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