Title: Highly Enantioselective Synthesis of Designed Chiral Acyclonucleosides and Acyclonucleotides by Organocatalytic Aza‐Michael Addition
Abstract: Chemistry – A European JournalVolume 17, Issue 15 p. 4095-4098 Communication Highly Enantioselective Synthesis of Designed Chiral Acyclonucleosides and Acyclonucleotides by Organocatalytic Aza-Michael Addition Prof. Dr. Hai-Ming Guo, Corresponding Author Prof. Dr. Hai-Ming Guo [email protected] College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University, 46 Jianshe Road, Xinxiang, 453007 (P. R. China), Fax: (+86) 373-332-9276College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University, 46 Jianshe Road, Xinxiang, 453007 (P. R. China), Fax: (+86) 373-332-9276Search for more papers by this authorDr. Teng-Fei Yuan, Dr. Teng-Fei Yuan College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University, 46 Jianshe Road, Xinxiang, 453007 (P. R. China), Fax: (+86) 373-332-9276Search for more papers by this authorDr. Hong-Ying Niu, Dr. Hong-Ying Niu School of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, 1 Hualan Avenue, Xinxiang 453003 (P. R. China)Search for more papers by this authorJin-Ying Liu, Jin-Ying Liu College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University, 46 Jianshe Road, Xinxiang, 453007 (P. R. China), Fax: (+86) 373-332-9276Search for more papers by this authorRun-Ze Mao, Run-Ze Mao College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University, 46 Jianshe Road, Xinxiang, 453007 (P. R. China), Fax: (+86) 373-332-9276Search for more papers by this authorDe-Yang Li, De-Yang Li College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University, 46 Jianshe Road, Xinxiang, 453007 (P. R. China), Fax: (+86) 373-332-9276Search for more papers by this authorProf. Gui-Rong Qu, Corresponding Author Prof. Gui-Rong Qu [email protected] College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University, 46 Jianshe Road, Xinxiang, 453007 (P. R. China), Fax: (+86) 373-332-9276College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University, 46 Jianshe Road, Xinxiang, 453007 (P. R. China), Fax: (+86) 373-332-9276Search for more papers by this author Prof. Dr. Hai-Ming Guo, Corresponding Author Prof. Dr. Hai-Ming Guo [email protected] College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University, 46 Jianshe Road, Xinxiang, 453007 (P. R. China), Fax: (+86) 373-332-9276College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University, 46 Jianshe Road, Xinxiang, 453007 (P. R. China), Fax: (+86) 373-332-9276Search for more papers by this authorDr. Teng-Fei Yuan, Dr. Teng-Fei Yuan College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University, 46 Jianshe Road, Xinxiang, 453007 (P. R. China), Fax: (+86) 373-332-9276Search for more papers by this authorDr. Hong-Ying Niu, Dr. Hong-Ying Niu School of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, 1 Hualan Avenue, Xinxiang 453003 (P. R. China)Search for more papers by this authorJin-Ying Liu, Jin-Ying Liu College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University, 46 Jianshe Road, Xinxiang, 453007 (P. R. China), Fax: (+86) 373-332-9276Search for more papers by this authorRun-Ze Mao, Run-Ze Mao College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University, 46 Jianshe Road, Xinxiang, 453007 (P. R. China), Fax: (+86) 373-332-9276Search for more papers by this authorDe-Yang Li, De-Yang Li College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University, 46 Jianshe Road, Xinxiang, 453007 (P. R. China), Fax: (+86) 373-332-9276Search for more papers by this authorProf. Gui-Rong Qu, Corresponding Author Prof. Gui-Rong Qu [email protected] College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University, 46 Jianshe Road, Xinxiang, 453007 (P. R. China), Fax: (+86) 373-332-9276College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University, 46 Jianshe Road, Xinxiang, 453007 (P. R. China), Fax: (+86) 373-332-9276Search for more papers by this author First published: 08 March 2011 https://doi.org/10.1002/chem.201100435Citations: 52Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract Chiral acyclonucleosides were synthesized by an organocatalytic asymmetric aza-Michael addition reaction from achiral purine bases and α,β-unsaturated aldehydes in 82–89 % yield and up to 99 % ee. The isolated chiral acyclonucleosides are readily converted to acyclonucleotides. Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description chem_201100435_sm_miscellaneous_information.pdf2.8 MB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume17, Issue15April 4, 2011Pages 4095-4098 RelatedInformation
Publication Year: 2011
Publication Date: 2011-03-08
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 56
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