Publication Information

{'id': 'https://openalex.org/W2125149319', 'doi': 'https://doi.org/10.1073/pnas.77.7.3957', 'title': 'Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.', 'display_name': 'Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.', 'publication_year': 1980, 'publication_date': '1980-07-01', 'ids': {'openalex': 'https://openalex.org/W2125149319', 'doi': 'https://doi.org/10.1073/pnas.77.7.3957', 'mag': '2125149319', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/6933445', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/349746'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1073/pnas.77.7.3957', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc349746?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5108454557', 'display_name': 'Alfred W. Alberts', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'A W Alberts', 'raw_affiliation_strings': ['Department of Basic & Applied Microbiology, and tDepartment of Biophysics, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065'], 'affiliations': [{'raw_affiliation_string': 'Department of Basic & Applied Microbiology, and tDepartment of Biophysics, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000728222', 'display_name': 'J Chen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J Chen', 'raw_affiliation_strings': ['Department of Basic & Applied Microbiology, and tDepartment of Biophysics, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065'], 'affiliations': [{'raw_affiliation_string': 'Department of Basic & Applied Microbiology, and tDepartment of Biophysics, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112017422', 'display_name': 'G. W. Kuron', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'G Kuron', 'raw_affiliation_strings': ['Department of Basic & Applied Microbiology, and tDepartment of Biophysics, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065'], 'affiliations': [{'raw_affiliation_string': 'Department of Basic & Applied Microbiology, and tDepartment of Biophysics, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052516262', 'display_name': 'V. M. Hunt', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'V Hunt', 'raw_affiliation_strings': ['Department of Basic & Applied Microbiology, and tDepartment of Biophysics, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065'], 'affiliations': [{'raw_affiliation_string': 'Department of Basic & Applied Microbiology, and tDepartment of Biophysics, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031127856', 'display_name': 'Jesse W. Huff', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J Huff', 'raw_affiliation_strings': ['Department of Basic & Applied Microbiology, and tDepartment of Biophysics, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065'], 'affiliations': [{'raw_affiliation_string': 'Department of Basic & Applied Microbiology, and tDepartment of Biophysics, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113644422', 'display_name': 'Cecilia Hoffman', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'C Hoffman', 'raw_affiliation_strings': ['Department of Biochemical Regulation, tNew Leads Discovery Department,'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemical Regulation, tNew Leads Discovery Department,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030544850', 'display_name': 'John W. Rothrock', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'J Rothrock', 'raw_affiliation_strings': ['Department of Biochemical Regulation, tNew Leads Discovery Department,'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemical Regulation, tNew Leads Discovery Department,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113756925', 'display_name': 'M López', 'orcid': 'https://orcid.org/0000-0003-1713-4462'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'M Lopez', 'raw_affiliation_strings': ['Department of Biochemical Regulation, tNew Leads Discovery Department,'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemical Regulation, tNew Leads Discovery Department,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112225745', 'display_name': 'H Joshua', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'H Joshua', 'raw_affiliation_strings': ['Department of Biochemical Regulation, tNew Leads Discovery Department,'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemical Regulation, tNew Leads Discovery Department,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040108856', 'display_name': 'E. J. Harris', 'orcid': 'https://orcid.org/0000-0003-4926-8086'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'E Harris', 'raw_affiliation_strings': ['Department of Biochemical Regulation, tNew Leads Discovery Department,'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemical Regulation, tNew Leads Discovery Department,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065250230', 'display_name': 'Arthur A. Patchett', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'A Patchett', 'raw_affiliation_strings': ['Department of Biochemical Regulation, tNew Leads Discovery Department,'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemical Regulation, tNew Leads Discovery Department,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034446684', 'display_name': 'Richard L. Monaghan', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'R Monaghan', 'raw_affiliation_strings': ['Department of Biochemical Regulation, tNew Leads Discovery Department,'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemical Regulation, tNew Leads Discovery Department,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030525094', 'display_name': 'Susan Currie', 'orcid': 'https://orcid.org/0000-0002-4237-4428'}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'S Currie', 'raw_affiliation_strings': ['Department of Basic & Applied Microbiology, and tDepartment of Biophysics, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065'], 'affiliations': [{'raw_affiliation_string': 'Department of Basic & Applied Microbiology, and tDepartment of Biophysics, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072183205', 'display_name': 'E. O. Stapley', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'E Stapley', 'raw_affiliation_strings': ['Department of Biochemical Regulation, tNew Leads Discovery Department,'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemical Regulation, tNew Leads Discovery Department,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110665149', 'display_name': 'G. Albers‐Schönberg', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'G Albers-Schonberg', 'raw_affiliation_strings': ['Department of Biochemical Regulation, tNew Leads Discovery Department,'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemical Regulation, tNew Leads Discovery Department,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032174619', 'display_name': 'Otto D. Hensens', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'O Hensens', 'raw_affiliation_strings': ['Department of Biochemical Regulation, tNew Leads Discovery Department,'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemical Regulation, tNew Leads Discovery Department,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112444877', 'display_name': 'J. HIRSHFIELD', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'J Hirshfield', 'raw_affiliation_strings': ['Department of Biochemical Regulation, tNew Leads Discovery Department,'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemical Regulation, tNew Leads Discovery Department,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091251286', 'display_name': 'Karst Hoogsteen', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'K Hoogsteen', 'raw_affiliation_strings': ['Department of Biochemical Regulation, tNew Leads Discovery Department,'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemical Regulation, tNew Leads Discovery Department,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025190227', 'display_name': 'Jerrold M. Liesch', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'J Liesch', 'raw_affiliation_strings': ['Department of Biochemical Regulation, tNew Leads Discovery Department,'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemical Regulation, tNew Leads Discovery Department,', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5073111698', 'display_name': 'Jörn Springer', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'J Springer', 'raw_affiliation_strings': ['Department of Biochemical Regulation, tNew Leads Discovery Department,'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemical Regulation, tNew Leads Discovery Department,', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 16.239, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 1605, 'citation_normalized_percentile': {'value': 0.998994, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '77', 'issue': '7', 'first_page': '3957', 'last_page': '3961'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12673', 'display_name': 'Microbial Metabolism and Applications', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12673', 'display_name': 'Microbial Metabolism and Applications', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11882', 'display_name': 'Plant biochemistry and biosynthesis', 'score': 0.9931, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12817', 'display_name': 'Pharmacological Effects of Natural Compounds', 'score': 0.9832, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/aspergillus-terreus', 'display_name': 'Aspergillus terreus', 'score': 0.69782794}, {'id': 'https://openalex.org/keywords/lovastatin', 'display_name': 'Lovastatin', 'score': 0.676436}, {'id': 'https://openalex.org/keywords/hydroxymethylglutaryl-coa-reductase', 'display_name': 'Hydroxymethylglutaryl-CoA reductase', 'score': 0.47604704}, {'id': 'https://openalex.org/keywords/coenzyme-a', 'display_name': 'Coenzyme A', 'score': 0.43585205}, {'id': 'https://openalex.org/keywords/mevalonic-acid', 'display_name': 'Mevalonic acid', 'score': 0.41493565}], 'concepts': [{'id': 'https://openalex.org/C134651460', 'wikidata': 'https://www.wikidata.org/wiki/Q3100717', 'display_name': 'Reductase', 'level': 3, 'score': 0.72945714}, {'id': 'https://openalex.org/C2776781318', 'wikidata': 'https://www.wikidata.org/wiki/Q3798237', 'display_name': 'Aspergillus terreus', 'level': 2, 'score': 0.69782794}, {'id': 'https://openalex.org/C2780940807', 'wikidata': 'https://www.wikidata.org/wiki/Q417740', 'display_name': 'Lovastatin', 'level': 3, 'score': 0.676436}, {'id': 'https://openalex.org/C2777477808', 'wikidata': 'https://www.wikidata.org/wiki/Q407595', 'display_name': 'Metabolite', 'level': 2, 'score': 0.590318}, {'id': 'https://openalex.org/C2776980637', 'wikidata': 'https://www.wikidata.org/wiki/Q427492', 'display_name': 'Enzyme inhibitor', 'level': 3, 'score': 0.56355554}, {'id': 'https://openalex.org/C150757390', 'wikidata': 'https://www.wikidata.org/wiki/Q1985205', 'display_name': 'Non-competitive inhibition', 'level': 3, 'score': 0.5203616}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.5065187}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.48138455}, {'id': 'https://openalex.org/C2777320049', 'wikidata': 'https://www.wikidata.org/wiki/Q2989497', 'display_name': 'Hydroxymethylglutaryl-CoA reductase', 'level': 5, 'score': 0.47604704}, {'id': 'https://openalex.org/C2778163477', 'wikidata': 'https://www.wikidata.org/wiki/Q43656', 'display_name': 'Cholesterol', 'level': 2, 'score': 0.44866997}, {'id': 'https://openalex.org/C2779123261', 'wikidata': 'https://www.wikidata.org/wiki/Q407635', 'display_name': 'Coenzyme A', 'level': 4, 'score': 0.43585205}, {'id': 'https://openalex.org/C104950815', 'wikidata': 'https://www.wikidata.org/wiki/Q415607', 'display_name': 'HMG-CoA reductase', 'level': 4, 'score': 0.4257099}, {'id': 'https://openalex.org/C2780361610', 'wikidata': 'https://www.wikidata.org/wiki/Q241678', 'display_name': 'Mevalonic acid', 'level': 4, 'score': 0.41493565}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.3517937}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.3045256}], 'mesh': [{'descriptor_ui': 'D000924', 'descriptor_name': 'Anticholesteremic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D019161', 'descriptor_name': 'Hydroxymethylglutaryl-CoA Reductase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009281', 'descriptor_name': 'Naphthalenes', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002784', 'descriptor_name': 'Cholesterol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002784', 'descriptor_name': 'Cholesterol', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D002784', 'descriptor_name': 'Cholesterol', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D004285', 'descriptor_name': 'Dogs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008148', 'descriptor_name': 'Lovastatin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009281', 'descriptor_name': 'Naphthalenes', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': False}, {'descriptor_ui': 'D009281', 'descriptor_name': 'Naphthalenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1073/pnas.77.7.3957', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc349746', 'pdf_url': 'https://europepmc.org/articles/pmc349746?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC349746', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/6933445', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc349746', 'pdf_url': 'https://europepmc.org/articles/pmc349746?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 24, 'referenced_works': ['https://openalex.org/W13351788', 'https://openalex.org/W1513741126', 'https://openalex.org/W1557733310', 'https://openalex.org/W1603091820', 'https://openalex.org/W1885778179', 'https://openalex.org/W1964836458', 'https://openalex.org/W1972677139', 'https://openalex.org/W1974079370', 'https://openalex.org/W1975445796', 'https://openalex.org/W1977644047', 'https://openalex.org/W1995889326', 'https://openalex.org/W2007604569', 'https://openalex.org/W2009277424', 'https://openalex.org/W20106710', 'https://openalex.org/W2013253881', 'https://openalex.org/W2023867538', 'https://openalex.org/W2048989715', 'https://openalex.org/W2049114103', 'https://openalex.org/W2053770173', 'https://openalex.org/W2055561625', 'https://openalex.org/W2056903868', 'https://openalex.org/W2066281438', 'https://openalex.org/W2066982995', 'https://openalex.org/W2112698709'], 'related_works': ['https://openalex.org/W3024196814', 'https://openalex.org/W2952840006', 'https://openalex.org/W2949635307', 'https://openalex.org/W2730177848', 'https://openalex.org/W2257157743', 'https://openalex.org/W2077672507', 'https://openalex.org/W2073987498', 'https://openalex.org/W2055281491', 'https://openalex.org/W2052696736', 'https://openalex.org/W1977462909'], 'abstract_inverted_index': {'Mevinolin,': [0], 'a': [1, 28, 50, 143], 'fungal': [2], 'metabolite,': [3], 'was': [4, 34, 96, 115, 119], 'isolated': [5], 'from': [6], 'cultures': [7], 'of': [8, 16, 30, 54, 66, 80, 100, 129, 148], 'Aspergillus': [9], 'terreus.': [10], 'The': [11], 'structure': [12], 'and': [13, 18], 'absolute': [14], 'configuration': [15], 'mevinolini': [17], 'its': [19, 64], 'open': [20], 'acid': [21, 40, 78], 'form,': [22, 46], 'mevinolinic': [23, 47], 'acid,': [24, 48], 'were': [25], 'determined': [26], 'by': [27], 'combination': [29], 'physical': [31], 'techniques.': [32], 'Mevinolin': [33, 42], 'shown': [35, 116], 'to': [36, 72], 'be': [37, 70], '1,2,6,7,8,8a-hexahydro-beta,': [38], 'delta-dihydroxy-2,6-dimethyl-8-(2-methyl-1-oxobutoxy)-1-naphthalene-hepatanoic': [39], 'delta-lactone.': [41], 'in': [43, 103, 125, 142], 'the': [44, 76, 81, 90, 126], 'hydroxy-acid': [45], 'is': [49], 'potent': [51], 'competitive': [52], 'inhibitor': [53, 99], '3-hydroxy-3-methylglutaryl-coenzyme': [55], 'A': [56], 'reductase': [57], '[mevalonate:': [58], 'NADP+': [59], 'oxidoreductase': [60], '(CoA-acylating),': [61], 'EC': [62], '1.1.1.34];': [63], 'Ki': [65], '0.6': [67], 'nM': [68, 74], 'can': [69], 'compared': [71], '1.4': [73], 'for': [75, 131], 'hydroxy': [77], 'form': [79], 'previously': [82], 'described': [83], 'related': [84], 'inhibitor,': [85], 'ML-236B': [86], '(compactin,': [87], '6-demethylmevinolin).': [88], 'In': [89], 'rat,': [91], 'orally': [92, 121], 'administered': [93], 'sodium': [94], 'mevinolinate': [95], 'an': [97, 104, 120], 'active': [98, 122], 'cholesterol': [101], 'synthesis': [102], 'acute': [105], 'assay': [106], '(50%': [107], 'inhibitory': [108], 'dose': [109], '=': [110], '46': [111], 'microgram/kg).': [112], 'Furthermore,': [113], 'it': [114], 'that': [117], 'mevinolin': [118, 135], 'cholesterol-lowering': [123], 'agent': [124], 'dog.': [127], 'Treatment': [128], 'dogs': [130], '3': [132], 'weeks': [133], 'with': [134], 'at': [136], '8': [137], 'mg/kg': [138], 'per': [139], 'day': [140], 'resulted': [141], '29.3': [144], '+/-': [145], '2.5%': [146], 'lowering': [147], 'plasma': [149], 'cholesterol.': [150]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2125149319', 'counts_by_year': [{'year': 2024, 'cited_by_count': 23}, {'year': 2023, 'cited_by_count': 35}, {'year': 2022, 'cited_by_count': 30}, {'year': 2021, 'cited_by_count': 34}, {'year': 2020, 'cited_by_count': 40}, {'year': 2019, 'cited_by_count': 36}, {'year': 2018, 'cited_by_count': 39}, {'year': 2017, 'cited_by_count': 32}, {'year': 2016, 'cited_by_count': 34}, {'year': 2015, 'cited_by_count': 43}, {'year': 2014, 'cited_by_count': 61}, {'year': 2013, 'cited_by_count': 53}, {'year': 2012, 'cited_by_count': 47}], 'updated_date': '2024-12-13T12:07:44.890883', 'created_date': '2016-06-24'}