Title: Tumor Necrosis Factor as a Pharmacological Target
Abstract:Tumor necrosis factor (TNF) was originally described as a molecule with antitumor properties released by macrophages stimulated with bacterial products. Almost at the same time that TNF was cloned, it...Tumor necrosis factor (TNF) was originally described as a molecule with antitumor properties released by macrophages stimulated with bacterial products. Almost at the same time that TNF was cloned, it was found to be identical to cachectin, a mediator of cachexia. After the finding of this second aspect of TNF action, several studies demonstrated its role as a proinflammatory cytokine. These studies led to the use of anti-TNF molecules in rheumatoid arthritis and Crohn's disease. The various strategies used to inhibit TNF are summarized.Read More
Publication Year: 2004
Publication Date: 2004-04-02
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 24
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot