Title: CREATINE-CREATININE METABOLISM AND THE HORMONES VIII. THE EFFECT OF INCUBATION OF DIFFERENT TISSUES WITH AND WITHOUT PITOCIN, PITRESSIN AND THYROXIN UPON THE CREATINE-CREATININE EQUILIBRIUM IN VITRO
Abstract:IT Is WELL KNOWN that during thyrotoxicosis or after administration of thyroxin there is an increase in creatine excretion followed by a retention of creatinine. Pitressin and pitocin cause a retentio...IT Is WELL KNOWN that during thyrotoxicosis or after administration of thyroxin there is an increase in creatine excretion followed by a retention of creatinine. Pitressin and pitocin cause a retention of the creatinine formed in the body from amino acid metabolism followed by a quantitative increase in creatine excretion. It is, therefore, possible that creatinine may be the mother substance of creatine under these conditions. The experiments performed during the present study were designed to investigate this possibility. A search for enzymes capable of acting on creatine and creatinine was also made. Creatinine, free from creatine, was dissolved in a phosphate buffer of pH 7 in physiological saline to contain 1 mg. of creatinine per cc. Fifty mg. of creatinine was used in the first four studies and 100 mg. in the last study. To these solutions different amounts of rat tissues and the hormone solutions were added in the amounts shown in the tables and chart. In one study 100 mg.Read More
Publication Year: 1942
Publication Date: 1942-02-01
Language: en
Type: article
Indexed In: ['crossref']
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