Publication Information

{'id': 'https://openalex.org/W2124748423', 'doi': None, 'title': '[Pretreatment with dexmedetomidine ameliorates renal inflammation and oxidative stress in rats with lipopolysaccharide-induced sepsis and acute kidney injury].', 'display_name': '[Pretreatment with dexmedetomidine ameliorates renal inflammation and oxidative stress in rats with lipopolysaccharide-induced sepsis and acute kidney injury].', 'publication_year': 2015, 'publication_date': '2015-10-01', 'ids': {'openalex': 'https://openalex.org/W2124748423', 'mag': '2124748423', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26547344'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26547344', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100459043', 'display_name': 'Yujie Chen', 'orcid': 'https://orcid.org/0000-0002-9905-9138'}, 'institutions': [{'id': 'https://openalex.org/I4210117827', 'display_name': 'Guangzhou Development Zone Hospital', 'ror': 'https://ror.org/02bpgfv91', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210117827']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yu-Jie Chen', 'raw_affiliation_strings': ['Department of Intensive Care Unit, Guangzhou Economic Technological Development Zone Hospital, Guangzhou 510730, China. E-mail: [email protected].'], 'affiliations': [{'raw_affiliation_string': 'Department of Intensive Care Unit, Guangzhou Economic Technological Development Zone Hospital, Guangzhou 510730, China. E-mail: [email protected].', 'institution_ids': ['https://openalex.org/I4210117827']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046459318', 'display_name': 'Chulian Gong', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Chu-Lian Gong', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029837106', 'display_name': 'Fang Tan', 'orcid': 'https://orcid.org/0000-0003-2406-129X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Fang Tan', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5102863131', 'display_name': 'Shaoli Zhou', 'orcid': 'https://orcid.org/0000-0002-6604-0166'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Shao-Li Zhou', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.453, 'has_fulltext': False, 'cited_by_count': 12, 'citation_normalized_percentile': {'value': 0.709748, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '35', 'issue': '10', 'first_page': '1472', 'last_page': '5'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12963', 'display_name': 'Anesthesia and Neurotoxicity Research', 'score': 0.9901, 'subfield': {'id': 'https://openalex.org/subfields/2806', 'display_name': 'Developmental Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12963', 'display_name': 'Anesthesia and Neurotoxicity Research', 'score': 0.9901, 'subfield': {'id': 'https://openalex.org/subfields/2806', 'display_name': 'Developmental Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10436', 'display_name': 'Anesthesia and Sedative Agents', 'score': 0.9847, 'subfield': {'id': 'https://openalex.org/subfields/2703', 'display_name': 'Anesthesiology and Pain Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12626', 'display_name': 'Cancer, Stress, Anesthesia, and Immune Response', 'score': 0.9435, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dexmedetomidine', 'display_name': 'Dexmedetomidine', 'score': 0.80203927}, {'id': 'https://openalex.org/keywords/intraperitoneal-injection', 'display_name': 'Intraperitoneal injection', 'score': 0.5532764}], 'concepts': [{'id': 'https://openalex.org/C2781302539', 'wikidata': 'https://www.wikidata.org/wiki/Q412133', 'display_name': 'Dexmedetomidine', 'level': 3, 'score': 0.80203927}, {'id': 'https://openalex.org/C2778754761', 'wikidata': 'https://www.wikidata.org/wiki/Q421804', 'display_name': 'Lipopolysaccharide', 'level': 2, 'score': 0.79962164}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.74166226}, {'id': 'https://openalex.org/C2780091579', 'wikidata': 'https://www.wikidata.org/wiki/Q9377', 'display_name': 'Kidney', 'level': 2, 'score': 0.6469892}, {'id': 'https://openalex.org/C2777676773', 'wikidata': 'https://www.wikidata.org/wiki/Q412226', 'display_name': 'Yohimbine', 'level': 4, 'score': 0.6254021}, {'id': 'https://openalex.org/C2778384902', 'wikidata': 'https://www.wikidata.org/wiki/Q183134', 'display_name': 'Sepsis', 'level': 2, 'score': 0.611681}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.58887804}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.5564676}, {'id': 'https://openalex.org/C2780159080', 'wikidata': 'https://www.wikidata.org/wiki/Q1400536', 'display_name': 'Intraperitoneal injection', 'level': 2, 'score': 0.5532764}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.55117315}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5358805}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.5043863}, {'id': 'https://openalex.org/C2778690821', 'wikidata': 'https://www.wikidata.org/wiki/Q212354', 'display_name': 'Cytokine', 'level': 2, 'score': 0.44847015}, {'id': 'https://openalex.org/C2780472472', 'wikidata': 'https://www.wikidata.org/wiki/Q424337', 'display_name': 'Acute kidney injury', 'level': 2, 'score': 0.42330647}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.27132845}, {'id': 'https://openalex.org/C2776885963', 'wikidata': 'https://www.wikidata.org/wiki/Q245204', 'display_name': 'Antagonist', 'level': 3, 'score': 0.08493802}, {'id': 'https://openalex.org/C2776814716', 'wikidata': 'https://www.wikidata.org/wiki/Q574801', 'display_name': 'Sedation', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D058186', 'descriptor_name': 'Acute Kidney Injury', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D020927', 'descriptor_name': 'Dexmedetomidine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D018384', 'descriptor_name': 'Oxidative Stress', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D018805', 'descriptor_name': 'Sepsis', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D058186', 'descriptor_name': 'Acute Kidney Injury', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020927', 'descriptor_name': 'Dexmedetomidine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053583', 'descriptor_name': 'Interleukin-1beta', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D053583', 'descriptor_name': 'Interleukin-1beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008315', 'descriptor_name': 'Malondialdehyde', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008315', 'descriptor_name': 'Malondialdehyde', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018805', 'descriptor_name': 'Sepsis', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D018805', 'descriptor_name': 'Sepsis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26547344', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.63, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2949031076', 'https://openalex.org/W2400445066', 'https://openalex.org/W2187940769', 'https://openalex.org/W2185598964', 'https://openalex.org/W2153962342', 'https://openalex.org/W2133351730', 'https://openalex.org/W2124748423', 'https://openalex.org/W2100439660', 'https://openalex.org/W1970516311', 'https://openalex.org/W1010530109'], 'abstract_inverted_index': {'To': [0], 'investigate': [1], 'the': [2, 42, 48, 61, 97, 105, 111, 114, 131, 154, 171, 179], 'effects': [3], 'of': [4, 18, 91], 'dexmedetomidine': [5, 50], 'on': [6], 'inflammatory': [7, 180], 'reaction,': [8], 'oxidative': [9, 184], 'stress,': [10, 185], 'and': [11, 69, 81, 94, 99, 104, 123, 126, 133, 146, 149, 156, 163, 182, 186], 'renal': [12, 100, 106, 134, 139, 157, 167, 175], 'pathologies': [13, 107], 'in': [14, 96, 116, 130, 153, 159], 'a': [15, 31], 'rat': [16], 'model': [17], 'lipopolysaccharide': [19], '(LPS)-induced': [20], 'sepsis.Thirty-two': [21], 'SD': [22], 'rats': [23, 115, 161, 172], 'were': [24, 102, 108], 'randomly': [25], 'divided': [26], 'into': [27], '4': [28], 'groups,': [29], 'including': [30], 'sham-operated': [32, 112], 'group,': [33], 'LPS': [34, 37, 67, 87, 117], 'group': [35, 53, 71, 118], 'with': [36, 54, 72, 110, 137], '(5': [38], 'mg/kg)': [39, 76], 'injection': [40, 59, 77, 83], 'via': [41, 60], 'caudal': [43, 62], 'vein': [44, 63], '30': [45], 'min': [46, 65, 79, 85], 'before': [47, 66, 80, 86], 'operation,': [49], '(Dex)': [51], '+LPS': [52], 'additional': [55], 'Dex': [56, 82, 141], '(10': [57], 'µg/kg)': [58], '10': [64, 84], 'injection,': [68], 'yohimbine+DEX+LPS': [70], 'intraperitoneal': [73], 'yohimbine': [74], '(1': [75], '40': [78], 'injection.': [88], 'The': [89], 'levels': [90, 125, 148], 'IL-1β,': [92], 'SOD': [93, 128, 151], 'MDA': [95, 124, 147], 'plasma': [98, 132, 155], 'tissues': [101, 135, 158], 'determined,': [103], 'examined.Compared': [109], 'rats,': [113], 'showed': [119], 'significantly': [120, 164], 'increased': [121], 'IL-1β': [122, 145], 'lowered': [127, 144], 'activity': [129, 152], '(P<0.05)': [136], 'obvious': [138], 'pathologies.': [140], 'pretreatment': [142], 'obviously': [143], 'enhanced': [150], 'LPS-challenged': [160], '(P<0.05),': [162], 'lessened': [165], 'LPS-induced': [166, 174], 'pathologies.Dex': [168], 'can': [169], 'protect': [170], 'against': [173], 'injury': [176], 'by': [177, 192], 'alleviating': [178], 'reactions': [181], 'cytokine': [183], 'this': [187], 'effect': [188], 'is': [189], 'mediated': [190], 'possibly': [191], 'α2': [193], 'receptors.': [194]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2124748423', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}], 'updated_date': '2025-01-05T03:19:28.462076', 'created_date': '2016-06-24'}