Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2124560610', 'doi': 'https://doi.org/10.1056/nejmoa043445', 'title': 'Bortezomib or High-Dose Dexamethasone for Relapsed Multiple Myeloma', 'display_name': 'Bortezomib or High-Dose Dexamethasone for Relapsed Multiple Myeloma', 'publication_year': 2005, 'publication_date': '2005-06-15', 'ids': {'openalex': 'https://openalex.org/W2124560610', 'doi': 'https://doi.org/10.1056/nejmoa043445', 'mag': '2124560610', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15958804'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1056/nejmoa043445', 'pdf_url': 'https://www.nejm.org/doi/pdf/10.1056/NEJMoa043445?articleTools=true', 'source': {'id': 'https://openalex.org/S62468778', 'display_name': 'New England Journal of Medicine', 'issn_l': '0028-4793', 'issn': ['0028-4793', '1533-4406'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320239', 'host_organization_name': 'Massachusetts Medical Society', 'host_organization_lineage': ['https://openalex.org/P4310320239'], 'host_organization_lineage_names': ['Massachusetts Medical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.nejm.org/doi/pdf/10.1056/NEJMoa043445?articleTools=true', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5043526996', 'display_name': 'Paul G. Richardson', 'orcid': 'https://orcid.org/0000-0002-7426-8865'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Paul G. Richardson', 'raw_affiliation_strings': ['Dana–Farber Cancer Institute, Boston'], 'affiliations': [{'raw_affiliation_string': 'Dana–Farber Cancer Institute, Boston', 'institution_ids': ['https://openalex.org/I4210117453']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002972322', 'display_name': 'Pieter Sonneveld', 'orcid': 'https://orcid.org/0000-0002-0808-2237'}, 'institutions': [{'id': 'https://openalex.org/I907135538', 'display_name': 'Rotterdam University of Applied Sciences', 'ror': 'https://ror.org/0481e1q24', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I907135538']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Pieter Sonneveld', 'raw_affiliation_strings': ['University Hospital Rotterdam, Rotterdam, the Netherlands'], 'affiliations': [{'raw_affiliation_string': 'University Hospital Rotterdam, Rotterdam, the Netherlands', 'institution_ids': ['https://openalex.org/I907135538']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5106408675', 'display_name': 'Michael W. Schuster', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1340179700', 'display_name': 'NewYork–Presbyterian Hospital', 'ror': 'https://ror.org/03gzbrs57', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1340179700']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael W. Schuster', 'raw_affiliation_strings': ['New York–Presbyterian Hospital, New York'], 'affiliations': [{'raw_affiliation_string': 'New York–Presbyterian Hospital, New York', 'institution_ids': ['https://openalex.org/I1340179700']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109801302', 'display_name': 'David Irwin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210153265', 'display_name': 'Alta Bates Summit Medical Center', 'ror': 'https://ror.org/03w37n116', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I114073160', 'https://openalex.org/I4210153265']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David Irwin', 'raw_affiliation_strings': ['Alta Bates Cancer Center, Berkeley, Calif.'], 'affiliations': [{'raw_affiliation_string': 'Alta Bates Cancer Center, Berkeley, Calif.', 'institution_ids': ['https://openalex.org/I4210153265']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029801761', 'display_name': 'Edward A. Stadtmauer', 'orcid': 'https://orcid.org/0000-0002-3935-6069'}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Edward A. Stadtmauer', 'raw_affiliation_strings': ['University of Pennsylvania Cancer Center, Philadelphia'], 'affiliations': [{'raw_affiliation_string': 'University of Pennsylvania Cancer Center, Philadelphia', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024315315', 'display_name': 'Thierry Façon', 'orcid': 'https://orcid.org/0000-0001-7705-8460'}, 'institutions': [{'id': 'https://openalex.org/I4210155195', 'display_name': 'Hôpital Claude Huriez', 'ror': 'https://ror.org/05cpv3t46', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018718406', 'https://openalex.org/I4210155195']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Thierry Facon', 'raw_affiliation_strings': ['Hospital Claude Huriez, Lille, France'], 'affiliations': [{'raw_affiliation_string': 'Hospital Claude Huriez, Lille, France', 'institution_ids': ['https://openalex.org/I4210155195']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110474614', 'display_name': 'Jean‐Luc Harousseau', 'orcid': None}, 'institutions': [], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Jean-Luc Harousseau', 'raw_affiliation_strings': ['Hotel Dieu Hospital, Nantes, France'], 'affiliations': [{'raw_affiliation_string': 'Hotel Dieu Hospital, Nantes, France', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109357219', 'display_name': 'Dina Ben‐Yehuda', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3131873961', 'display_name': 'Hadassah Academic College', 'ror': 'https://ror.org/03bdv1r55', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I3131873961']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Dina Ben-Yehuda', 'raw_affiliation_strings': ['Hadassah University Hospital, Jerusalem'], 'affiliations': [{'raw_affiliation_string': 'Hadassah University Hospital, Jerusalem', 'institution_ids': ['https://openalex.org/I3131873961']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023276777', 'display_name': 'Sagar Lonial', 'orcid': 'https://orcid.org/0000-0002-8322-9323'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sagar Lonial', 'raw_affiliation_strings': ['Emory University, Atlanta'], 'affiliations': [{'raw_affiliation_string': 'Emory University, Atlanta', 'institution_ids': ['https://openalex.org/I150468666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055916434', 'display_name': 'Hartmut Goldschmidt', 'orcid': 'https://orcid.org/0000-0003-0961-0035'}, 'institutions': [{'id': 'https://openalex.org/I2802164966', 'display_name': 'University Hospital Heidelberg', 'ror': 'https://ror.org/013czdx64', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802164966']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Hartmut Goldschmidt', 'raw_affiliation_strings': ['Universitaetsklinikum Heidelberg, Heidelberg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Universitaetsklinikum Heidelberg, Heidelberg, Germany', 'institution_ids': ['https://openalex.org/I2802164966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043490010', 'display_name': 'Donna Reece', 'orcid': 'https://orcid.org/0009-0002-9686-4323'}, 'institutions': [{'id': 'https://openalex.org/I4210119445', 'display_name': 'Princess Margaret Hospital', 'ror': 'https://ror.org/02h6j4611', 'country_code': 'NZ', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210119445']}], 'countries': ['NZ'], 'is_corresponding': False, 'raw_author_name': 'Donna Reece', 'raw_affiliation_strings': ['Princess Margaret Hospital, Toronto'], 'affiliations': [{'raw_affiliation_string': 'Princess Margaret Hospital, Toronto', 'institution_ids': ['https://openalex.org/I4210119445']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020989412', 'display_name': 'Jesús F. San Miguel', 'orcid': 'https://orcid.org/0000-0002-9183-4857'}, 'institutions': [{'id': 'https://openalex.org/I4210099034', 'display_name': 'Complejo Hospitalario de Salamanca', 'ror': 'https://ror.org/0131vfw26', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I184999862', 'https://openalex.org/I4210099034']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Jesus F. San-Miguel', 'raw_affiliation_strings': ['Hospital Universitario de Salamanca, Salamanca, Spain'], 'affiliations': [{'raw_affiliation_string': 'Hospital Universitario de Salamanca, Salamanca, Spain', 'institution_ids': ['https://openalex.org/I4210099034']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031837957', 'display_name': 'Joan Bladé', 'orcid': 'https://orcid.org/0000-0002-4563-3405'}, 'institutions': [{'id': 'https://openalex.org/I4210160192', 'display_name': "Consorci Institut D'Investigacions Biomediques August Pi I Sunyer", 'ror': 'https://ror.org/054vayn55', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I4210160192', 'https://openalex.org/I4387153040']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Joan Bladé', 'raw_affiliation_strings': ["Institut d'Investigacions Biomèdiques Agusti Pi i Sunyer, Barcelona"], 'affiliations': [{'raw_affiliation_string': "Institut d'Investigacions Biomèdiques Agusti Pi i Sunyer, Barcelona", 'institution_ids': ['https://openalex.org/I4210160192']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018139001', 'display_name': 'Mario Boccadoro', 'orcid': 'https://orcid.org/0000-0001-8130-5209'}, 'institutions': [{'id': 'https://openalex.org/I55143463', 'display_name': 'University of Turin', 'ror': 'https://ror.org/048tbm396', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I55143463']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Mario Boccadoro', 'raw_affiliation_strings': ['Università di Torino, Torino, Italy'], 'affiliations': [{'raw_affiliation_string': 'Università di Torino, Torino, Italy', 'institution_ids': ['https://openalex.org/I55143463']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113527719', 'display_name': 'Jamie Cavenagh', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1307195382', 'display_name': "St Bartholomew's Hospital", 'ror': 'https://ror.org/00nh9x179', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1307195382', 'https://openalex.org/I225661044']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Jamie Cavenagh', 'raw_affiliation_strings': ["St. Bartholomew's Hospital, London"], 'affiliations': [{'raw_affiliation_string': "St. Bartholomew's Hospital, London", 'institution_ids': ['https://openalex.org/I1307195382']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103061547', 'display_name': 'William S. Dalton', 'orcid': 'https://orcid.org/0000-0001-9417-2599'}, 'institutions': [{'id': 'https://openalex.org/I3019308854', 'display_name': 'Moffitt Cancer Center', 'ror': 'https://ror.org/01xf75524', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3019308854']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'William S. Dalton', 'raw_affiliation_strings': ['H. Lee Moffitt Cancer Center, Tampa, Fla.'], 'affiliations': [{'raw_affiliation_string': 'H. Lee Moffitt Cancer Center, Tampa, Fla.', 'institution_ids': ['https://openalex.org/I3019308854']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109292881', 'display_name': 'Anthony Boral', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210147799', 'display_name': 'Millennium Engineering and Integration (United States)', 'ror': 'https://ror.org/05qmdfk04', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210147799']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Anthony L. Boral', 'raw_affiliation_strings': ['Millennium Pharmaceuticals, Cambridge, Mass.'], 'affiliations': [{'raw_affiliation_string': 'Millennium Pharmaceuticals, Cambridge, Mass.', 'institution_ids': ['https://openalex.org/I4210147799']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110217259', 'display_name': 'Dixie Esseltine', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210147799', 'display_name': 'Millennium Engineering and Integration (United States)', 'ror': 'https://ror.org/05qmdfk04', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210147799']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dixie L. Esseltine', 'raw_affiliation_strings': ['Millennium Pharmaceuticals, Cambridge, Mass.'], 'affiliations': [{'raw_affiliation_string': 'Millennium Pharmaceuticals, Cambridge, Mass.', 'institution_ids': ['https://openalex.org/I4210147799']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109877776', 'display_name': 'Jane Porter', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210147799', 'display_name': 'Millennium Engineering and Integration (United States)', 'ror': 'https://ror.org/05qmdfk04', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210147799']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jane B. Porter', 'raw_affiliation_strings': ['Millennium Pharmaceuticals, Cambridge, Mass.'], 'affiliations': [{'raw_affiliation_string': 'Millennium Pharmaceuticals, Cambridge, Mass.', 'institution_ids': ['https://openalex.org/I4210147799']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034783996', 'display_name': 'David P. Schenkein', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210147799', 'display_name': 'Millennium Engineering and Integration (United States)', 'ror': 'https://ror.org/05qmdfk04', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210147799']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David Schenkein', 'raw_affiliation_strings': ['Millennium Pharmaceuticals, Cambridge, Mass.'], 'affiliations': [{'raw_affiliation_string': 'Millennium Pharmaceuticals, Cambridge, Mass.', 'institution_ids': ['https://openalex.org/I4210147799']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5032464400', 'display_name': 'Kenneth C. Anderson', 'orcid': 'https://orcid.org/0000-0002-6418-0886'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kenneth C. Anderson', 'raw_affiliation_strings': ['Dana–Farber Cancer Institute, Boston'], 'affiliations': [{'raw_affiliation_string': 'Dana–Farber Cancer Institute, Boston', 'institution_ids': ['https://openalex.org/I4210117453']}]}], 'institution_assertions': [], 'countries_distinct_count': 9, 'institutions_distinct_count': 16, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 85.865, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 2461, 'citation_normalized_percentile': {'value': 0.999809, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '352', 'issue': '24', 'first_page': '2487', 'last_page': '2498'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10649', 'display_name': 'Multiple Myeloma Research and Treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10649', 'display_name': 'Multiple Myeloma Research and Treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12534', 'display_name': 'Protein Degradation and Inhibitors', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12505', 'display_name': 'Peptidase Inhibition and Analysis', 'score': 0.996, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.93027645}, {'id': 'https://openalex.org/C2777478702', 'wikidata': 'https://www.wikidata.org/wiki/Q419319', 'display_name': 'Bortezomib', 'level': 3, 'score': 0.88648605}, {'id': 'https://openalex.org/C2780401358', 'wikidata': 'https://www.wikidata.org/wiki/Q422252', 'display_name': 'Dexamethasone', 'level': 2, 'score': 0.7361819}, {'id': 'https://openalex.org/C2776364478', 'wikidata': 'https://www.wikidata.org/wiki/Q467635', 'display_name': 'Multiple myeloma', 'level': 2, 'score': 0.7295006}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.46805805}, {'id': 'https://openalex.org/C2780108899', 'wikidata': 'https://www.wikidata.org/wiki/Q15366934', 'display_name': 'Carfilzomib', 'level': 4, 'score': 0.45879245}, {'id': 'https://openalex.org/C2776063141', 'wikidata': 'https://www.wikidata.org/wiki/Q425681', 'display_name': 'Lenalidomide', 'level': 3, 'score': 0.4485107}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.43326432}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D001897', 'descriptor_name': 'Boronic Acids', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D003907', 'descriptor_name': 'Dexamethasone', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D009101', 'descriptor_name': 'Multiple Myeloma', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D011480', 'descriptor_name': 'Protease Inhibitors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D011719', 'descriptor_name': 'Pyrazines', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D001897', 'descriptor_name': 'Boronic Acids', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D001897', 'descriptor_name': 'Boronic Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000069286', 'descriptor_name': 'Bortezomib', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003907', 'descriptor_name': 'Dexamethasone', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D003907', 'descriptor_name': 'Dexamethasone', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D003907', 'descriptor_name': 'Dexamethasone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018450', 'descriptor_name': 'Disease Progression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005500', 'descriptor_name': 'Follow-Up Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006402', 'descriptor_name': 'Hematologic Diseases', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D006402', 'descriptor_name': 'Hematologic Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009101', 'descriptor_name': 'Multiple Myeloma', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D009101', 'descriptor_name': 'Multiple Myeloma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009101', 'descriptor_name': 'Multiple Myeloma', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D010976', 'descriptor_name': 'Platelet Count', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011480', 'descriptor_name': 'Protease Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011480', 'descriptor_name': 'Protease Inhibitors', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D011719', 'descriptor_name': 'Pyrazines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011719', 'descriptor_name': 'Pyrazines', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D012008', 'descriptor_name': 'Recurrence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015996', 'descriptor_name': 'Survival Rate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1056/nejmoa043445', 'pdf_url': 'https://www.nejm.org/doi/pdf/10.1056/NEJMoa043445?articleTools=true', 'source': {'id': 'https://openalex.org/S62468778', 'display_name': 'New England Journal of Medicine', 'issn_l': '0028-4793', 'issn': ['0028-4793', '1533-4406'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320239', 'host_organization_name': 'Massachusetts Medical Society', 'host_organization_lineage': ['https://openalex.org/P4310320239'], 'host_organization_lineage_names': ['Massachusetts Medical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15958804', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1056/nejmoa043445', 'pdf_url': 'https://www.nejm.org/doi/pdf/10.1056/NEJMoa043445?articleTools=true', 'source': {'id': 'https://openalex.org/S62468778', 'display_name': 'New England Journal of Medicine', 'issn_l': '0028-4793', 'issn': ['0028-4793', '1533-4406'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320239', 'host_organization_name': 'Massachusetts Medical Society', 'host_organization_lineage': ['https://openalex.org/P4310320239'], 'host_organization_lineage_names': ['Massachusetts Medical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.79}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 37, 'referenced_works': ['https://openalex.org/W1942425143', 'https://openalex.org/W1972960351', 'https://openalex.org/W1978377409', 'https://openalex.org/W1980471295', 'https://openalex.org/W1988265934', 'https://openalex.org/W2002846981', 'https://openalex.org/W2004550095', 'https://openalex.org/W2019162748', 'https://openalex.org/W2036343984', 'https://openalex.org/W2038504752', 'https://openalex.org/W2040081814', 'https://openalex.org/W2055182902', 'https://openalex.org/W2058680827', 'https://openalex.org/W2059707463', 'https://openalex.org/W2062289218', 'https://openalex.org/W2073139525', 'https://openalex.org/W2081446774', 'https://openalex.org/W2082230294', 'https://openalex.org/W2085269223', 'https://openalex.org/W2102591890', 'https://openalex.org/W2105258029', 'https://openalex.org/W2107154392', 'https://openalex.org/W2108235071', 'https://openalex.org/W2120161314', 'https://openalex.org/W2136226957', 'https://openalex.org/W2138102966', 'https://openalex.org/W2144719592', 'https://openalex.org/W2146502962', 'https://openalex.org/W2148537814', 'https://openalex.org/W2166834611', 'https://openalex.org/W2252935656', 'https://openalex.org/W2264313156', 'https://openalex.org/W2333363976', 'https://openalex.org/W2602697735', 'https://openalex.org/W3145716452', 'https://openalex.org/W4231388513', 'https://openalex.org/W4285719527'], 'related_works': ['https://openalex.org/W4310160996', 'https://openalex.org/W4310120201', 'https://openalex.org/W3217566318', 'https://openalex.org/W3029900969', 'https://openalex.org/W3006850578', 'https://openalex.org/W2892083382', 'https://openalex.org/W2556049602', 'https://openalex.org/W2200095709', 'https://openalex.org/W1998625437', 'https://openalex.org/W1985864219'], 'abstract_inverted_index': {'This': [0], 'study': [1, 121], 'compared': [2], 'bortezomib': [3, 35, 117, 127, 161, 189, 218, 235, 254], 'with': [4, 9, 25, 126, 148, 234, 253, 262, 274], 'high-dose': [5, 70, 267], 'dexamethasone': [6, 71, 109, 166, 191, 225, 268], 'in': [7, 118, 187, 247, 256], 'patients': [8, 24, 146, 216, 223, 251, 273], 'relapsed': [10, 26], 'multiple': [11, 275], 'myeloma': [12, 27, 276], 'who': [13, 104, 277], 'had': [14, 128, 279], 'received': [15], 'one': [16, 283], 'to': [17, 28, 107, 112, 115, 135, 185, 266, 284], 'three': [18, 66, 285], 'previous': [19, 286], 'therapies.We': [20], 'randomly': [21], 'assigned': [22, 106], '669': [23], 'receive': [29, 108, 116], 'either': [30], 'an': [31], 'intravenous': [32], 'bolus': [33], 'of': [34, 41, 250, 259, 272], '(1.3': [36], 'mg': [37, 73], 'per': [38], 'square': [39], 'meter': [40], 'body-surface': [42], 'area)': [43], 'on': [44, 58, 75, 94], 'days': [45, 59, 76, 95], '1,': [46, 60], '4,': [47, 79], '8,': [48, 61], 'and': [49, 63, 83, 141, 153, 162, 168, 176, 190, 198, 219, 227, 255], '11': [50], 'for': [51, 65, 87, 99, 160, 165, 231, 269], 'eight': [52], 'three-week': [53], 'cycles,': [54, 68, 90], 'followed': [55, 91], 'by': [56, 92], 'treatment': [57, 93, 271], '15,': [62], '22': [64], 'five-week': [67, 89], 'or': [69, 241], '(40': [72], 'orally)': [74], '1': [77, 96, 179], 'through': [78, 81, 85, 97], '9': [80], '12,': [82], '17': [84], '20': [86], 'four': [88], '4': [98, 242], 'five': [100], 'four-week': [101], 'cycles.': [102], 'Patients': [103], 'were': [105, 110, 157, 173, 193, 245], 'permitted': [111], 'cross': [113], 'over': [114], 'a': [119, 132, 142, 280], 'companion': [120], 'after': [122, 282], 'disease': [123], 'progression.Patients': [124], 'treated': [125, 147, 252, 261], 'higher': [129], 'response': [130, 155, 171], 'rates,': [131], 'longer': [133, 143], 'time': [134], 'progression': [136, 186], '(the': [137], 'primary': [138], 'end': [139], 'point),': [140], 'survival': [144, 210, 233], 'than': [145, 178], 'dexamethasone.': [149], 'The': [150, 208], 'combined': [151], 'complete': [152, 170], 'partial': [154], 'rates': [156, 172], '38': [158], 'percent': [159, 164, 175, 214, 221, 249, 258], '18': [163], '(P<0.001),': [167], 'the': [169, 188, 228, 270], '6': [174], 'less': [177], 'percent,': [180], 'respectively': [181, 203], '(P<0.001).': [182], 'Median': [183], 'times': [184], 'groups': [192], '6.22': [194], 'months': [195, 200], '(189': [196], 'days)': [197], '3.49': [199], '(106': [201], 'days),': [202], '(hazard': [204], 'ratio,': [205], '0.55;': [206], 'P<0.001).': [207], 'one-year': [209], 'rate': [211], 'was': [212, 236], '80': [213], 'among': [215, 222], 'taking': [217, 224], '66': [220], '(P=0.003),': [226], 'hazard': [229], 'ratio': [230], 'overall': [232], '0.57': [237], '(P=0.001).': [238], 'Grade': [239], '3': [240], 'adverse': [243], 'events': [244], 'reported': [246], '75': [248], '60': [257], 'those': [260], 'dexamethasone.Bortezomib': [263], 'is': [264], 'superior': [265], 'have': [278], 'relapse': [281], 'therapies.': [287]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2124560610', 'counts_by_year': [{'year': 2024, 'cited_by_count': 42}, {'year': 2023, 'cited_by_count': 59}, {'year': 2022, 'cited_by_count': 60}, {'year': 2021, 'cited_by_count': 57}, {'year': 2020, 'cited_by_count': 86}, {'year': 2019, 'cited_by_count': 76}, {'year': 2018, 'cited_by_count': 96}, {'year': 2017, 'cited_by_count': 115}, {'year': 2016, 'cited_by_count': 125}, {'year': 2015, 'cited_by_count': 123}, {'year': 2014, 'cited_by_count': 154}, {'year': 2013, 'cited_by_count': 173}, {'year': 2012, 'cited_by_count': 176}], 'updated_date': '2025-01-11T17:30:15.772700', 'created_date': '2016-06-24'}