Reactive Oxygen Species Produced by NAD(P)H Oxidase Inhibit Apoptosis in Pancreatic Cancer Cells

Name: Work Video:
Duration: 3 min 30 s
Eva C. Vaquero; Mouad Edderkaoui; Stephen J. Pandol; Ilya Gukovsky; Anna S. Gukovskaya
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'https://openalex.org/W1984929537', 'https://openalex.org/W1983889201', 'https://openalex.org/W1977378846', 'https://openalex.org/W1970554352', 'https://openalex.org/W1963490811'], 'abstract_inverted_index': {'One': [0, 245, 514], 'reason': [1, 246], 'why': [2, 247], 'pancreatic': [3, 31, 35, 124, 188, 220, 233, 248, 276, 280, 369, 433, 465, 478, 517, 618, 704, 922, 2024, 2049, 2111, 2140, 2154, 2257, 3107, 3388, 4197], 'cancer': [4, 32, 125, 189, 221, 234, 249, 277, 370, 434, 466, 479, 518, 619, 705, 923, 1685, 1908, 2025, 2050, 2112, 2141, 2155, 3108, 3389, 4198], 'is': [5, 12, 115, 250, 257, 360, 492, 524, 613, 632, 1506, 1526, 1577, 1743, 2013, 2573, 2623, 2631, 2954], 'so': [6, 251], 'aggressive': [7, 252, 494], 'and': [8, 39, 73, 82, 84, 139, 165, 171, 202, 238, 253, 284, 318, 327, 329, 384, 410, 416, 447, 483, 499, 520, 551, 554, 917, 928, 945, 1094, 1135, 1371, 1399, 1453, 1571, 1734, 1813, 1906, 1971, 2018, 2105, 2130, 2266, 2301, 2321, 2327, 2348, 2359, 2371, 2423, 2487, 2503, 2512, 2517, 2664, 2696, 2732, 2776, 2787, 2873, 2997, 3004, 3134, 3179, 3188, 3192, 3236, 3256, 3269, 3314, 3399, 3551, 3626, 3657, 3682, 3768, 3795, 3831, 3841, 3936, 3957, 3972, 4069, 4080, 4175, 4210, 4212], 'unresponsive': [9, 254], 'to': [10, 15, 236, 255, 260, 481, 497, 522, 527, 615, 617, 621, 713, 1174, 1179, 1298, 1490, 1528, 1645, 1680, 1964, 2093, 2158, 2375, 2427, 2489, 2625, 2638, 2784, 3228, 3253, 3418, 3615, 3798, 3879, 3887], 'treatments': [11, 256], 'its': [13, 258, 525], 'resistance': [14, 235, 259, 480, 526, 620, 631, 2157], 'apoptosis.': [16, 224, 261, 469, 528, 622], 'We': [17, 262, 623, 2114], 'report': [18, 263], 'here': [19, 264], 'that': [20, 110, 129, 209, 265, 355, 374, 454, 625, 862, 910, 937, 1139, 1392, 1576, 1750, 1844, 2116, 2131, 2941, 3095, 3425, 4190], 'reactive': [21, 266, 639, 934], 'oxygen': [22, 267, 640], 'species': [23, 268], '(ROS)': [24, 269], 'are': [25, 270, 932, 966, 1116, 1362, 1488, 3426, 4135], 'a': [26, 111, 116, 241, 271, 356, 361, 486, 626, 867, 1088, 1128, 1494, 1573, 2191, 2205, 2315, 2335, 2509, 2523, 2806, 2834, 2960, 3157, 3204, 3243, 3469, 3632, 3642, 3671, 3748, 3759, 3939, 3984, 3994, 4039, 4076, 4083], 'prosurvival,': [27, 272], 'antiapoptotic': [28, 273, 532, 876, 1960], 'factor': [29, 53, 274, 298, 628, 2365], 'in': [30, 67, 105, 123, 133, 168, 187, 232, 275, 312, 350, 368, 378, 413, 432, 477, 703, 926, 929, 998, 1060, 1182, 1184, 1302, 1397, 1493, 1563, 1579, 1732, 1848, 2023, 2110, 2139, 2283, 2314, 2341, 2345, 2378, 2469, 2590, 2633, 2650, 2666, 2689, 2694, 2705, 2764, 2805, 2865, 2965, 2971, 2989, 3001, 3066, 3106, 3156, 3203, 3242, 3285, 3428, 3468, 3478, 3543, 3693, 3808, 3823, 3946, 3963, 3987, 4038, 4075, 4172, 4196], 'cells.': [33, 69, 126, 173, 278, 314, 371, 418, 706, 2026, 2113, 2142, 3109], 'Human': [34, 279, 1049], 'adenocarcinoma': [36, 281, 491, 2258], 'MIA': [37, 137, 169, 282, 382, 414, 2264, 2463, 3680, 4173, 4205], 'PaCa-2': [38, 138, 170, 283, 383, 415, 2265, 2388, 2464, 3681, 4174, 4206], 'PANC-1': [40, 140, 172, 285, 385, 417, 3683, 4176, 4213], 'cells': [41, 103, 141, 190, 222, 286, 348, 386, 435, 467, 924, 1000, 1051, 1187, 1305, 1651, 1686, 1864, 1909, 2051, 2331, 2390, 2402, 2466, 2591, 2647, 3390, 3530, 3563, 3684, 3769, 3945, 4214], 'generated': [42, 287, 702, 2189, 2397], 'ROS,': [43, 288, 638, 1056], 'which': [44, 289, 2507, 2521, 2572, 2630, 2953, 4062], 'was': [45, 290, 995, 1643, 1678, 2163, 2171, 2179, 2204, 2223, 2235, 2241, 2414, 2485, 2672, 2687, 2762, 2782, 2790, 2797, 2829, 2852, 2878, 2987, 3116, 3130, 3274, 3283, 3385, 3416, 3586, 3597, 3612, 3637, 3664, 3689, 3745, 3756, 3766, 3803, 3865, 3892, 3981, 4032, 4073, 4094, 4149, 4162], 'stimulated': [46, 62, 185, 291, 307, 430, 919, 4193], 'by': [47, 79, 94, 193, 214, 292, 324, 339, 438, 459, 968, 1122, 1967, 2102, 2122, 2134, 2398, 2575, 2587, 2699, 2831, 2880, 2947, 3037, 3053, 3239, 3321, 3600, 3639, 3666, 3791, 3867, 3974, 3983, 4096], 'growth': [48, 52, 57, 120, 210, 293, 297, 302, 365, 455, 659, 663, 1486, 1647, 1682, 1733, 2046, 2103, 2117, 2356, 2364, 4191], 'factors': [49, 60, 294, 305, 537, 1487, 2118, 4192], '(serum,': [50, 295], 'insulin-like': [51, 296, 662, 2355], 'I,': [54, 299], 'or': [55, 181, 300, 426, 596, 2367, 2693, 2815, 2841, 3008, 3145, 3649, 3776], 'fibroblast': [56, 301, 658, 2363], 'factor-2).': [58, 303], 'Growth': [59, 304, 1522, 4166], 'also': [61, 306, 865, 996], 'membrane': [63, 308, 1093, 1125, 2124, 2695], 'NAD(P)H': [64, 74, 113, 134, 162, 215, 309, 319, 358, 379, 407, 460, 1126, 1293, 2126, 2683, 2968, 3455], 'oxidase': [65, 75, 114, 135, 153, 163, 216, 310, 320, 359, 380, 398, 408, 461, 1170, 1294, 2127, 2231, 2969, 3329], 'activity': [66, 76, 164, 311, 321, 409, 2970, 3980], 'these': [68, 313, 3092], 'Both': [70, 315], 'intracellular': [71, 316, 4217], 'ROS': [72, 122, 166, 175, 212, 317, 367, 411, 420, 457, 633, 708, 870, 931, 965, 993, 1076, 1115, 1181, 1393, 1492, 1524, 1562, 1739, 1751, 1845, 1955, 1968, 2022, 2098, 2107, 2120, 2133, 2147, 2581, 2583, 4170, 4194, 4218], 'were': [77, 322, 2252, 2270, 2281, 2309, 2322, 2332, 2396, 2467, 2585, 2648, 2820, 3051, 3141, 3154, 3190, 3201, 3247, 3260, 3319, 3335, 3433, 3442, 3480, 3531, 3564, 3655, 3770, 3789, 3821, 3852, 3885, 3934], 'inhibited': [78, 161, 323, 406], 'antioxidants': [80, 325], 'tiron': [81, 326, 2838], 'N-acetylcysteine': [83, 328], 'the': [85, 145, 177, 330, 390, 422, 873, 1080, 1119, 1123, 1168, 1291, 1503, 1736, 2016, 2019, 2045, 2095, 2199, 2261, 2273, 2346, 2368, 2430, 2462, 2470, 2479, 2568, 2594, 2619, 2626, 2634, 2639, 2651, 2667, 2785, 2827, 2850, 2866, 2881, 2972, 2976, 2983, 3002, 3015, 3063, 3113, 3117, 3125, 3128, 3138, 3270, 3310, 3324, 3402, 3445, 3483, 3522, 3527, 3544, 3554, 3567, 3589, 3616, 3623, 3658, 3661, 3739, 3780, 3837, 3855, 3869, 3880, 3895, 3964, 4092, 4183], 'inhibitor': [86, 331, 3056], 'of': [87, 96, 119, 332, 341, 364, 531, 556, 921, 964, 1055, 1074, 1090, 1114, 1167, 1290, 1389, 1496, 1534, 1561, 1648, 1683, 1738, 1954, 2021, 2028, 2033, 2039, 2047, 2097, 2146, 2153, 2195, 2337, 2350, 2385, 2392, 2494, 2570, 2579, 2636, 2677, 2682, 2760, 2767, 2826, 2860, 2868, 2967, 2979, 3006, 3057, 3112, 3127, 3150, 3312, 3413, 3444, 3473, 3526, 3606, 3622, 3629, 3641, 3660, 3679, 3738, 3861, 3941, 3949, 3955, 4030, 4100, 4158], 'flavoprotein-dependent': [88, 333], 'oxidases,': [89, 334], 'diphenylene': [90, 335, 646], 'iodonium,': [91, 336], 'but': [92, 149, 337, 394, 3045], 'not': [93, 143, 338, 388, 3046, 3100], 'inhibitors': [95, 340, 2370, 2859], 'various': [97, 342, 2858], 'other': [98, 343, 2250, 2874], 'ROS-generating': [99, 344, 1091, 1360, 2861], 'enzymes.': [100, 345], 'Using': [101, 346], 'Rho0': [102, 347, 2386, 2389, 2465], 'deficient': [104, 349], 'mitochondrial': [106, 351, 670, 1081, 2393, 3315, 3325], 'DNA,': [107, 352], 'we': [108, 353, 882, 2566, 2981, 3337, 3492, 3904, 3997, 4104, 4188], 'showed': [109, 354, 884, 3017], 'nonmitochondrial': [112, 357, 2125], 'major': [117, 362], 'source': [118, 363, 2032], 'factor-induced': [121, 211, 366, 456, 1523], 'Among': [127, 372], 'proteins': [128, 373, 533, 575, 1166], 'have': [130, 375, 709, 1176, 1295, 1556], 'been': [131, 376, 711, 1177, 1296, 2887], 'implicated': [132, 377], 'activity,': [136, 381], 'do': [142, 387], 'express': [144, 150, 389, 395], 'phagocytic': [146, 391, 1292], 'gp91phox': [147, 392, 1134, 1175], 'subunit': [148, 393, 2232, 3330], 'several': [151, 396], 'nonphagocytic': [152, 397, 689, 999, 1169, 1304], '(NOX)': [154, 399, 1171], 'isoforms.': [155, 400], 'Transfection': [156, 401, 3611, 3635, 3678], 'with': [157, 176, 402, 421, 912, 1133, 1729, 2292, 2407, 2416, 2593, 2659, 2857, 2957, 3021, 3024, 3042, 3047, 3062, 3119, 3143, 3281, 3391, 3420, 3482, 3533, 3548, 3566, 3583, 3685, 3805, 3836, 3846, 3854, 3894, 4034, 4066], 'Nox4': [158, 179, 403, 424, 1642, 2187, 2197, 3686, 3740, 3752], 'antisense': [159, 404, 3687, 3741], 'oligonucleotide': [160, 405, 3688], 'production': [167, 412, 1301, 1525, 2686, 3105, 4195], 'Inhibiting': [174, 419], 'antioxidants,': [178, 423], 'antisense,': [180, 425], 'MnSOD': [182, 427, 3585, 3662], 'overexpression': [183, 428, 1567, 2038], 'all': [184, 429, 3443], 'apoptosis': [186, 431, 920, 1809, 1847, 2109, 2138], 'as': [191, 436, 535, 1085, 1087, 2035, 2037, 2434, 2703, 2822, 2863, 2959, 3336, 3491, 3691, 3758, 3903, 3993, 3996, 4103, 4137], 'measured': [192, 437, 2567, 2586, 2688, 2798, 2879, 2988, 3665, 3866, 3982, 4074], 'internucleosomal': [194, 439], 'DNA': [195, 440, 2394, 2484, 3625, 3863], 'fragmentation,': [196, 441], 'phosphatidylserine': [197, 442], 'externalization,': [198, 443], 'cytochrome': [199, 444, 3327], 'c': [200, 445, 2221, 2230, 3328, 4089], 'release,': [201, 446], 'effector': [203, 448], 'caspase': [204, 449, 3978], 'activation.': [205, 450], 'The': [206, 451, 1951, 2089, 2143, 2186, 2412, 2613, 2824, 3039, 3110, 3276, 3438, 3594, 3751, 4026, 4156], 'results': [207, 452, 3016, 3093], 'show': [208, 453, 1749, 3094], 'produced': [213, 458, 967, 1117], '(probably': [217, 462, 2128], 'Nox4)': [218, 463, 2129], 'protect': [219, 464], 'from': [223, 468, 1079, 2164, 2172, 2180, 2190, 2207, 2224, 2236, 2242, 2253, 2272, 3387, 3410, 3675, 3786, 3899, 4141], 'This': [225, 470, 2962], 'mechanism': [226, 471, 515, 1505, 2152], 'may': [227, 472, 864, 2148, 2963], 'play': [228, 473, 866, 1394], 'an': [229, 474, 493, 1142, 1558, 2040, 2150, 3055, 3102, 3773], 'important': [230, 475, 1559, 2151], 'role': [231, 476, 1560], 'treatment': [237, 482, 523], 'thus': [239, 484], 'represent': [240, 485], 'novel': [242, 487], 'therapeutic': [243, 488], 'target.': [244, 489], 'Pancreatic': [490, 4177], 'malignancy': [495], 'resistant': [496], 'chemotherapy': [498], 'radiotherapy': [500], '(1Wanebo': [501], 'H.J.': [502], 'Vezeridis': [503], 'M.P.': [504, 2438, 2451], 'Cancer.': [505, 901], '1996;': [506, 786, 1832, 1871, 2454, 2724], '78:': [507], '580-591Crossref': [508], 'PubMed': [509, 546, 568, 591, 608, 727, 745, 789, 815, 856, 905, 959, 988, 1011, 1029, 1044, 1107, 1160, 1224, 1237, 1257, 1282, 1322, 1354, 1383, 1416, 1448, 1465, 1481, 1519, 1549, 1604, 1637, 1672, 1723, 1765, 1783, 1835, 1874, 1901, 1946, 1987, 2007, 2445, 2457, 2608, 2727, 2752, 2912, 2936, 3087, 3356, 3379, 3516, 3731, 3928, 4021, 4128], 'Scopus': [510, 547, 569, 592, 609, 728, 746, 790, 816, 857, 906, 989, 1030, 1045, 1161, 1225, 1238, 1258, 1283, 1323, 1355, 1417, 1449, 1466, 1550, 1605, 1638, 1673, 1724, 1766, 1784, 1836, 1875, 1902, 1947, 1988, 2008, 2446, 2609, 2728, 2753, 2913, 2937, 3088, 3517, 3732, 3929, 4022, 4129], '(0)': [511], 'Google': [512, 549, 571, 594, 611, 730, 748, 764, 778, 792, 818, 859, 908, 960, 991, 1012, 1032, 1047, 1071, 1108, 1163, 1227, 1240, 1260, 1285, 1325, 1357, 1384, 1419, 1451, 1468, 1482, 1520, 1552, 1607, 1640, 1675, 1726, 1768, 1786, 1802, 1838, 1861, 1877, 1904, 1949, 1990, 2010, 2066, 2087, 2448, 2458, 2538, 2562, 2611, 2730, 2755, 2915, 2939, 3090, 3357, 3380, 3519, 3734, 3931, 4024, 4131], 'Scholar).': [513, 961, 992, 1048, 1072, 1109, 1164, 1286, 1358, 1385, 1483, 1521, 1553, 1641, 1727, 1803, 1839, 1950, 2011, 2088, 2459, 2563, 2612, 3381, 3520, 3932, 4025, 4132], 'mediating': [516, 629, 970], 'aggressiveness': [519], 'unresponsiveness': [521], 'Constitutive': [529], 'activation': [530], 'such': [534], 'transcription': [536, 557], 'NF-κB': [538, 1970], '(2Aggarwal': [539], 'B.B.': [540], 'Biochem.': [541, 983, 1155, 1247, 1412, 1545, 1828, 2000, 2603], 'Pharmacol.': [542, 758, 1796], '2000;': [543, 724, 737, 956, 1008, 1104, 1380, 1516, 1762, 1775, 3376], '60:': [544], '1033-1039Crossref': [545], '(147)': [548], 'Scholar)': [550, 612, 860, 909, 2940], 'signal': [552, 3129, 4065], 'transducers': [553], 'activators': [555], '(3Battle': [558], 'T.E.': [559, 2059], 'Frank': [560], 'D.A.': [561], 'Curr.': [562, 1231], 'Mol.': [563, 1977, 2060], 'Med.': [564, 2748, 2932, 3083], '2002;': [565, 605, 902, 985, 1021, 1157, 1234, 1279, 1669, 2063, 2933, 3084], '2:': [566], '381-392Crossref': [567], '(252)': [570], 'Scholar),': [572, 595, 765, 1420, 1452, 1862, 1878, 1905], 'heat': [573, 1972], 'shock': [574, 1973], '(4Beere': [576], 'H.M.': [577], 'Green': [578], 'D.R.': [579, 1976], 'Trends': [580, 1246], 'Cell': [581, 603, 1410, 1443, 1543, 2255, 3152, 3199, 3870], 'Biol.': [582, 805, 1019, 1344, 1444, 1891, 2747, 2902, 2931, 3082], '2001;': [583, 761, 1319, 1413, 1546, 1634, 1799, 2004, 2535, 2559, 2749], '11:': [584, 1414, 1547, 1980], '6-10Abstract': [585], 'Full': [586, 588, 740, 742, 810, 812, 1024, 1026, 1252, 1254, 1349, 1351, 1778, 1780, 1896, 1898, 1982, 1984, 2907, 2909, 3511, 3513, 3923, 3925, 4016, 4018, 4123, 4125], 'Text': [587, 589, 741, 743, 811, 813, 1025, 1027, 1253, 1255, 1350, 1352, 1779, 1781, 1897, 1899, 1983, 1985, 2908, 2910, 3512, 3514, 3924, 3926, 4017, 4019, 4124, 4126], 'PDF': [590, 744, 814, 1028, 1256, 1353, 1782, 1900, 1986, 2911, 3515, 3927, 4020, 4127], '(387)': [593], 'phosphatidylinositide': [597], '3-kinase': [598], '(5Nicholson': [599], 'K.M.': [600], 'Anderson': [601], 'N.G.': [602], 'Signal.': [604], '14:': [606, 1479], '381-395Crossref': [607], '(1394)': [610], 'thought': [614, 712], 'contribute': [616], 'hypothesized': [624], 'key': [627], 'this': [630, 880, 2872], '1The': [634], 'abbreviations': [635], 'used': [636, 2323, 2821, 3757], 'are:': [637], 'species;': [641], 'CMX-Ros,': [642], 'MitoTracker': [643, 3486], 'Red;': [644], 'DPI,': [645, 3054], 'iodonium;': [647], 'FACS,': [648], 'fluorescence-activated': [649], 'cell': [650, 715, 1497, 1574, 1741, 1753, 2156, 2259, 2691, 2990, 3257, 3653, 3787, 3888, 3989, 4199], 'sorter;': [651], 'FBS,': [652, 2352], 'fetal': [653, 2294], 'bovine': [654, 2295], 'serum;': [655], 'FGF-2,': [656], 'basic': [657, 2362], 'factor;': [660], 'IGF-I,': [661], 'factor-I;': [664], 'MnSOD,': [665, 2043], 'manganese': [666], 'superoxide': [667, 939, 1300, 2836, 2842, 2951], 'dismutase;': [668], 'mtDNA,': [669], 'DNA;': [671], 'NAC,': [672], 'N-acetylcysteine;': [673], 'AMC,': [674, 4061], 'aminomethylcoumarin;': [675], 'NOS,': [676], 'nitric-oxide': [677, 1365], 'synthase;': [678], 'PLA2,': [679], 'phospholipase': [680, 1368], 'A2;': [681], 'DCFH-DA,': [682, 2662, 4187], '2′,7′-dichlorofluorescein': [683], 'diacetate;': [684], 'CHAPS,': [685, 4050], '3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonic': [686], 'acid;': [687], 'NOX,': [688], 'oxidase;': [690], 'ELISA,': [691], 'enzyme-linked': [692], 'immunosorbent': [693], 'assay;': [694], 'l-NAME,': [695], 'N-ω-nitro-l-arginine': [696], 'methyl': [697], 'ester;': [698], 'AACOCF3,': [699], 'arachidonyl': [700], 'trifluoromethylketone.': [701], 'Although': [707], 'long': [710], 'promote': [714], 'death': [716, 1742, 1754], '(6Simon': [717, 1755], 'H.U.': [718, 1756], 'Haj-Yehia': [719, 1757], 'A.': [720, 1633, 1758, 1825], 'Levi-Schaffer': [721, 1759], 'F.': [722, 1760, 1827], 'Apoptosis.': [723, 1761], '5:': [725, 1763], '415-418Crossref': [726, 1764], '(2313)': [729, 1767], 'Scholar,': [731, 749, 779, 793, 819, 1013, 1033, 1228, 1241, 1261, 1326, 1469, 1608, 1769, 1787, 1991, 2067, 2449, 2539, 2916, 3091, 3358], '7Kannan': [732, 1770], 'K.': [733, 843, 1211, 1332, 1710, 1771, 1823, 1933, 3718], 'Jain': [734, 1772], 'S.K.': [735, 1773], 'Pathophysiology.': [736, 1774], '7:': [738, 1776], '153-163Abstract': [739, 1777], '(936)': [747, 1785], '8Davis': [750, 1788], 'Jr.,': [751, 1789, 2527], 'W.': [752, 981, 1153, 1790, 3603], 'Ronai': [753, 1791], 'Z.': [754, 823, 1191, 1309, 1690, 1792, 1913, 3698], 'Tew': [755, 1793], 'K.D.': [756, 1794], 'J.': [757, 773, 785, 804, 851, 900, 954, 1006, 1018, 1039, 1102, 1219, 1277, 1343, 1378, 1409, 1442, 1460, 1474, 1514, 1542, 1589, 1612, 1667, 1718, 1795, 1856, 1870, 1890, 1941, 2075, 2210, 2557, 2721, 2901, 3351, 3374, 3726], 'Exp.': [759, 1797], 'Ther.': [760, 1798, 2062], '296:': [762, 1800], '1-6PubMed': [763, 1801], 'recent': [766], 'data': [767, 1555, 1748, 1841, 3064, 3139], '(9Wedgwood': [768, 1851], 'S.': [769, 1437, 1622, 1632, 1852, 1995, 2708, 2710, 2740], 'Black': [770, 1853], 'S.M.': [771, 1854], 'Am.': [772, 850, 953, 1005, 1038, 1101, 1218, 1276, 1377, 1459, 1475, 1513, 1666, 1717, 1855, 1940, 2556, 3350, 3373, 3725], 'Physiol.': [774, 852, 955, 1007, 1040, 1103, 1220, 1278, 1379, 1411, 1461, 1515, 1544, 1668, 1719, 1857, 1942, 2558, 3352, 3375, 3727], '2003;': [775, 853, 1041, 1221, 1249, 1346, 1445, 1462, 1478, 1720, 1858, 1943, 1979, 2084, 3508, 3728, 3920, 4013, 4120], '285:': [776, 854, 1042, 1222, 1463, 1721, 1859, 1944, 3729], 'L305-L312PubMed': [777, 1860], '10Clement': [780], 'M.V.': [781, 1866], 'Stamenkovic': [782, 1867], 'I.': [783, 1868, 3341, 3362, 3430, 3502, 3914, 4007, 4114], 'EMBO': [784, 1869], '15:': [787, 1872], '216-225Crossref': [788, 1873], '(234)': [791, 1876], '11Lin': [794], 'K.I.': [795, 1881], 'Pasinelli': [796, 1882], 'P.': [797, 892, 1423, 1883, 2894], 'Brown': [798, 1884], 'R.H.': [799, 1885], 'Hardwick': [800, 1886], 'J.M.': [801, 1015, 1471, 1887], 'Ratan': [802, 1888], 'R.R.': [803, 1889], 'Chem.': [806, 1020, 1345, 1892, 2903], '1999;': [807, 1601, 1893], '274:': [808, 1894], '13650-13655Abstract': [809, 1895], '(32)': [817, 1903], '12Brar': [820, 3695], 'S.S.': [821, 1189, 1263, 1653, 1688, 1911, 3696], 'Corbin': [822, 1190, 1689, 1912, 3697], 'Kennedy': [824, 1192, 1264, 1654, 1691, 1914, 3699], 'T.P.': [825, 839, 1063, 1193, 1207, 1265, 1269, 1655, 1659, 1692, 1706, 1915, 1929, 3700, 3714], 'Hemendinger': [826, 1194, 1693, 1916, 3701], 'R.': [827, 1195, 1328, 1431, 1620, 1694, 1917, 2532, 3702], 'Thornton': [828, 1196, 1695, 1918, 3703], 'L.': [829, 1197, 1429, 1696, 1919, 1997, 3704], 'Bommarius': [830, 1198, 1697, 1920, 3705], 'B.': [831, 1035, 1199, 1456, 1587, 1698, 1921, 2738, 3706], 'Arnold': [832, 1200, 1584, 1699, 1922, 3707], 'R.S.': [833, 1201, 1585, 1610, 1700, 1923, 3708], 'Whorton': [834, 1202, 1272, 1662, 1701, 1924, 3709], 'A.R.': [835, 1203, 1273, 1663, 1702, 1925, 3710], 'Sturrock': [836, 1204, 1266, 1656, 1703, 1926, 3711], 'A.B.': [837, 1205, 1267, 1595, 1657, 1704, 1927, 3712], 'Huecksteadt': [838, 1206, 1268, 1658, 1705, 1928, 3713], 'Quinn': [840, 1208, 1270, 1660, 1707, 1930, 3715], 'M.T.': [841, 1209, 1271, 1661, 1708, 1931, 3716], 'Krenitsky': [842, 1210, 1709, 1932, 3717], 'Ardie': [844, 1212, 1711, 1934, 3719], 'K.G.': [845, 1213, 1712, 1935, 3720], 'Lambeth': [846, 978, 1150, 1214, 1315, 1598, 1625, 1713, 1936, 3721], 'J.D.': [847, 979, 1151, 1215, 1230, 1316, 1599, 1626, 1714, 1937, 3722], 'Hoidal': [848, 1216, 1274, 1664, 1715, 1938, 3723], 'J.R.': [849, 1217, 1275, 1665, 1716, 1939, 3724], 'C353-C369Crossref': [855, 1223, 1722, 1945, 3730], '(226)': [858, 1226, 1725, 1948, 3733], 'suggest': [861], 'they': [863], 'prosurvival': [868, 1952, 2144], 'role.': [869], 'can': [871, 1956, 2946], 'activate': [872], 'above': [874, 2471], 'mentioned': [875], 'signaling': [877, 1395], 'pathways.': [878], 'In': [879, 1110, 1484, 1804, 2847, 2871, 3060, 4203], 'regard,': [881], 'recently': [883], '(13Mouria': [885], 'M.': [886, 1334, 1336, 1407, 1435, 1540, 2714, 2918, 3069, 3364, 3498, 3910, 4003, 4110], 'Gukovskaya': [887, 3342, 3371, 3505, 3917, 4010, 4117], 'A.S.': [888, 3343, 3372, 3506, 3918, 4011, 4118], 'Jung': [889], 'Y.': [890, 2890], 'Buechler': [891], 'Hines': [893], 'O.J.': [894], 'Reber': [895], 'H.A.': [896], 'Pandol': [897, 3348, 3369, 3503, 3915, 4008, 4115], 'S.J.': [898, 3349, 3370, 3504, 3916, 4009, 4116], 'Int.': [899], '98:': [903, 1635], '761-769Crossref': [904], '(263)': [907], 'compounds': [911], 'antioxidative': [913], 'properties,': [914], 'quercetin,': [915], 'resveratrol': [916], 'genistein,': [918], 'both': [925, 3317, 4204], 'vitro': [927], 'vivo.': [930], 'highly': [933, 2640], 'O2': [935], 'metabolites': [936], 'include': [938, 1077], 'radical': [940, 947], '(O2−˙),': [941], 'hydrogen': [942], 'peroxide': [943], '(H2O2),': [944], 'hydroxyl': [946], '(OH·)': [948], '(14Thannickal': [949, 1001, 1097, 1373, 1509], 'V.J.': [950, 1002, 1098, 1374, 1510], 'Fanburg': [951, 1003, 1099, 1375, 1511], 'B.L.': [952, 1004, 1100, 1376, 1512], '279:': [957, 1009, 1105, 1381, 1517, 3377], 'L1005-L1028Crossref': [958, 1010, 1106, 1382, 1518], 'Large': [962], 'quantities': [963], 'phagocytes,': [969, 1111], 'host': [971], 'defense': [972], 'against': [973], 'invading': [974], 'microorganisms': [975], '(15Babior': [976, 1148], 'B.M.': [977, 1149], 'Nauseef': [980, 1152], 'Arch.': [982, 1154, 2602], 'Biophys.': [984, 1156, 1829, 2001, 2604], '397:': [986, 1158], '342-344Crossref': [987, 1159], '(712)': [990, 1162], 'generation': [994, 2121], 'detected': [997, 3481], '16Li': [1014], 'Shah': [1016, 1472], 'A.M.': [1017, 1473, 1616], '277:': [1022], '19952-19960Abstract': [1023], '(341)': [1031], '17Lassegue': [1034], 'Clempus': [1036, 1457], 'R.E.': [1037, 1458], 'R277-R297Crossref': [1043, 1464], '(21)': [1046, 1467], 'tumor': [1050], 'produce': [1052], 'significant': [1053], 'amounts': [1054, 1113], 'albeit': [1057], 'smaller': [1058], 'than': [1059, 3023, 3034], 'phagocytes': [1061], '(18Szatrowski': [1062], 'Nathan': [1064], 'C.F.': [1065], 'Cancer': [1066, 2061, 2082, 2533], 'Res.': [1067, 1830, 2002, 2083, 2534], '1991;': [1068], '51:': [1069], '794-798PubMed': [1070], 'Sources': [1073], 'cellular': [1075, 2483], 'leakage': [1078], 'electron': [1082], 'transport': [1083], 'chain': [1084], 'well': [1086, 1129, 1745, 2036], 'number': [1089], 'plasma': [1092, 1124], 'cytosolic': [1095, 2697, 3271, 3313, 4101], 'enzymes': [1096, 1361, 2862], 'large': [1112], 'during': [1118], 'oxidative': [1120], 'burst': [1121], 'oxidase,': [1127, 1364], 'characterized': [1130], 'multicomponent': [1131], 'enzyme': [1132], 'p22phox': [1136], 'catalytic': [1137], 'subunits': [1138], 'together': [1140], 'form': [1141], 'integral': [1143], 'complex': [1144], 'called': [1145], 'flavocytochrome': [1146], 'b558': [1147], 'Recently,': [1165], 'family': [1172], 'homologous': [1173], 'shown': [1178, 2888], 'generate': [1180], 'nonphagocytic,': [1183], 'particular': [1185], 'cancer,': [1186], '(12Brar': [1188, 1687, 1910], '19Lambeth': [1229], 'Opin.': [1232], 'Hematol.': [1233], '9:': [1235], '11-17Crossref': [1236], '(232)': [1239], '20Bokoch': [1242], 'G.M.': [1243], 'Knaus': [1244], 'U.G.': [1245], 'Sci.': [1248, 1630], '28:': [1250], '502-508Abstract': [1251], '(351)': [1259], '21Brar': [1262], '282:': [1280, 1670], 'C1212-C1224Crossref': [1281, 1671], '(138)': [1284, 1674], 'Furthermore,': [1287], 'functional': [1288], 'components': [1289], 'found': [1297, 1644, 1679, 2115], 'mediate': [1299], 'some': [1303, 2848], '(22Cheng': [1306], 'G.': [1307, 1425, 1433, 1441, 1999, 2440], 'Cao': [1308], 'Xu': [1310, 1590], 'X.': [1311, 1591, 2922, 3073], 'van': [1312], 'Meir': [1313], 'E.G.': [1314], 'Gene': [1317], '(Amst.).': [1318], '269:': [1320], '131-140Crossref': [1321], '(707)': [1324], '23Takeya': [1327], 'Ueno': [1329], 'N.': [1330, 2528], 'Kami': [1331], 'Taura': [1333], 'Kohjima': [1335], 'Izaki': [1337], 'T.': [1338, 1439, 1819, 2712], 'Nunoi': [1339], 'H.': [1340, 1342, 1405, 1538, 2601, 2892], 'Sumimoto': [1341], '278:': [1347], '25234-25246Abstract': [1348], '(326)': [1356], 'Other': [1359], 'xanthine': [1363], 'synthase': [1366], '(NOS),': [1367], 'A2': [1369], '(PLA2),': [1370], 'lipoxygenases': [1372], 'A': [1386, 4209], 'growing': [1387], 'body': [1388], 'evidence': [1390], 'indicates': [1391], 'roles': [1396, 1731, 2020], 'physiologic': [1398], 'pathophysiologic': [1400], 'processes,': [1401], 'including': [1402], 'proliferation': [1403], '(24Sauer': [1404, 1537], 'Wartenberg': [1406, 1539], 'Hescheler': [1408, 1541], '173-186Crossref': [1415, 1548], '(929)': [1418, 1551], 'adhesion': [1421], '(25Chiarugi': [1422], 'Pani': [1424], 'Giannoni': [1426], 'E.': [1427, 1614, 3368], 'Taddei': [1428], 'Colavitti': [1430], 'Raugei': [1432], 'Symons': [1434], 'Borrello': [1436], 'Galeotti': [1438], 'Ramponi': [1440], '161:': [1446], '933-944Crossref': [1447], '(366)': [1450], 'hypertension': [1454], '(17Lassegue': [1455], '26Li': [1470], 'Soc.': [1476], 'Nephrol.': [1477], 'S221-S226Crossref': [1480], 'particular,': [1485, 1805], 'known': [1489, 1963, 2014], 'stimulate': [1491, 1752, 2119, 2949], 'variety': [1495], 'types': [1498], 'through': [1499, 1959, 4180], 'receptor-transducing': [1500], 'pathways,': [1501], 'although': [1502], 'detailed': [1504], 'poorly': [1507, 2262], 'understood': [1508], 'believed': [1527], 'be': [1529, 1957, 1965, 2149], 'necessary': [1530], 'for': [1531, 2373, 2404, 2429, 2653, 2802, 2854, 3173, 3181, 3230, 3266, 3305, 3323, 3453, 3537, 3575, 3631, 3747, 3772, 3833, 3843, 3966, 4086], 'optimal': [1532], 'propagation': [1533], 'mitogenic': [1535], 'signals': [1536, 3031], 'Recent': [1554, 1840], 'demonstrated': [1557], 'neoplastic': [1564], 'proliferation.': [1565], 'Nox1': [1566], 'transforms': [1568], 'normal': [1569], 'fibroblasts': [1570], 'creates': [1572], 'line': [1575], 'tumorigenic': [1578], 'athymic': [1580], 'mice': [1581], '(27Suh': [1582], 'Y.A.': [1583], 'Lassegue': [1586, 2737], 'Shi': [1588, 1611], 'Sorescu': [1592], 'D.': [1593, 2079, 2734], 'Chung': [1594], 'Griendling': [1596, 2717, 2743], 'K.K.': [1597, 2718, 2744], 'Nature.': [1600], '401:': [1602], '79-82Crossref': [1603], '(1284)': [1606], '28Arnold': [1609], 'Murad': [1613], 'Whalen': [1615], 'Sun': [1617], 'C.Q.': [1618], 'Polavarapu': [1619], 'Parthasarathy': [1621], 'Petros': [1623], 'J.A.': [1624, 2599], 'Proc.': [1627], 'Natl.': [1628], 'Acad.': [1629], 'U.': [1631], '5550-5555Crossref': [1636], '(423)': [1639], 'regulate': [1646, 1681], 'malignant': [1649], 'melanoma': [1650], '(21Brar': [1652], 'Scholar);': [1676], 'Nox5': [1677], 'prostate': [1684, 1907], 'Compared': [1728], 'their': [1730, 2100], 'proliferation,': [1735], 'effect': [1737, 1953, 2145, 2978], 'on': [1740, 2674, 3553], 'less': [1744], 'understood.': [1746], 'Most': [1747], 'exogenous': [1806], 'H2O2': [1807, 2637], 'causes': [1808], 'at': [1810, 1815, 2311, 2334, 2656, 2799, 2942, 2992, 3132, 3176, 3184, 3194, 3233, 3249, 3262, 3435, 3540, 3938, 3969, 4054, 4142], 'low': [1811], 'doses': [1812, 1817, 2944], 'necrosis': [1814], 'high': [1816, 2943], '(29Sakamoto': [1818], 'Repasky': [1820], 'W.T.': [1821], 'Uchida': [1822], 'Hirata': [1824, 1826], 'Commun.': [1831, 2003], '220:': [1833], '643-647Crossref': [1834], '(79)': [1837], 'suggest,': [1842], 'however,': [1843, 3124], 'inhibit': [1846], 'smooth': [1849], 'muscle': [1850], 'leukemia': [1863], '(10Clement': [1865], 'colorectal': [1879], '(11Lin': [1880], 'mediated': [1958], 'redox-sensitive': [1961, 2595, 4184], 'pathways': [1962], 'activated': [1966], '(e.g.': [1969], 'proteins)': [1974], '(30Green': [1975], 'Cell.': [1978], '551-552Abstract': [1981], '(48)': [1989], '31Garrido': [1992], 'C.': [1993, 2071], 'Gurbuxani': [1994], 'Ravagnan': [1996], 'Kroemer': [1998], '286:': [2005], '433-442Crossref': [2006], '(669)': [2009], 'Little': [2012], 'about': [2015], 'sources': [2017, 2096], 'Inhibition': [2027], 'lipoxygenase': [2029], '(a': [2030], 'putative': [2031], 'ROS)': [2034], 'antioxidant': [2041], 'enzyme,': [2042], 'attenuated': [2044], 'human': [2048, 2196, 2495, 3421, 3454, 3584], '(32Tong': [2052], 'W.G.': [2053], 'Ding': [2054], 'X.Z.': [2055], 'Witt': [2056], 'R.C.': [2057], 'Adrian': [2058], '1:': [2064], '929-935PubMed': [2065], '33Cullen': [2068], 'J.J.': [2069], 'Weydert': [2070], 'Hinkhouse': [2072], 'M.M.': [2073], 'Ritchie': [2074], 'Domann': [2076], 'F.E.': [2077], 'Spitz': [2078], 'Oberley': [2080, 3604], 'L.W.': [2081], '63:': [2085], '1297-1303PubMed': [2086], 'present': [2090], 'study': [2091], 'sought': [2092], 'determine': [2094], 'generation,': [2099], 'stimulation': [2101], 'factors,': [2104], 'whether': [2106], 'affect': [2108], 'activating': [2123], 'inhibiting': [2132], 'different': [2135], 'approaches': [2136], 'stimulates': [2137], 'therapy.': [2159], 'Reagents—2′,7′-Dichlorofluorescein': [2160], 'diacetate': [2161], '(DCFH-DA)': [2162], 'Molecular': [2165, 2237, 3489], 'Probes,': [2166], 'Inc.': [2167, 2175, 2245], '(Eugene,': [2168], 'OR);': [2169], 'Ac-Asp-Glu-Val-Asp-AMC': [2170, 3992], 'Peptide': [2173], 'Institute,': [2174], '(Osaka,': [2176], 'Japan);': [2177], 'benzyloxycarbonyl-Val-Ala-Asp(OMe)-CH2F': [2178], 'Enzyme': [2181], 'Systems': [2182], 'Products': [2183], '(Livermore,': [2184], 'CA).': [2185, 2307, 2813], 'antibody': [2188, 2222, 2234, 2240, 3674], 'His-tagged': [2192], 'recombinant': [2193], 'fragment': [2194], '(encoding': [2198], 'C-terminal': [2200], 'amino': [2201], 'acids': [2202], '494–513)': [2203], 'gift': [2206], 'Dr.': [2208, 3601], 'Barry': [2209], 'Goldstein': [2211], '(Jefferson': [2212], 'Medical': [2213], 'College,': [2214], 'Thomas': [2215], 'Jefferson': [2216], 'University,': [2217], 'Philadelphia,': [2218], 'PA).': [2219], 'Anti-cytochrome': [2220], 'PharMingen': [2225], '(San': [2226], 'Diego,': [2227], 'CA);': [2228], 'anti-cytochrome': [2229], 'IV': [2233], 'Probes;': [2238], 'anti-MnSOD': [2239, 3673], 'Upstate': [2243, 3676], 'Biotechnology,': [2244], '(Lake': [2246], 'Placid,': [2247], 'NY).': [2248], 'All': [2249], 'reagents': [2251], 'Sigma.': [2254], 'Culture—Human': [2256], 'lines,': [2260], 'differentiated': [2263, 2268], 'moderately': [2267], 'PANC-1,': [2269], 'obtained': [2271, 3041, 3142, 3386], 'American': [2274], 'Type': [2275], 'Culture': [2276], 'Collection': [2277], '(Manassas,': [2278], 'VA).': [2279], 'Cells': [2280, 2308, 3933, 4179], 'grown': [2282], '1:1': [2284], "Dulbecco's": [2285, 2379], 'modified': [2286, 2380], "Eagle's": [2287, 2381], 'medium/F-12': [2288, 2382], 'medium': [2289, 2413, 2473, 2668, 3765], '(Gibco)': [2290], 'supplemented': [2291, 2415], '15%': [2293, 2351], 'serum': [2296], '(FBS),': [2297], '4': [2298, 2326, 3177, 3234], 'mm': [2299, 2769, 2774, 2778, 3161, 3164, 3208, 3211, 3214, 3217, 3220, 3223, 3293, 3812, 3816, 4043, 4052], 'l-glutamine,': [2300], 'antibiotic/antimicotic': [2302], 'solution': [2303], '(Omega': [2304], 'Scientific,': [2305], 'Tarzana,': [2306], 'maintained': [2310], '37': [2312, 2657, 3541, 4055], '°C': [2313, 2658, 3178, 3196, 3542], 'humidified': [2316], 'atmosphere': [2317], 'containing': [2318, 2772, 3826, 3952], '5%': [2319, 3806], 'CO2': [2320], 'between': [2324], 'passages': [2325], '12.': [2328], 'For': [2329, 2564], 'analyses,': [2330], 'plated': [2333], 'density': [2336, 3940], '5': [2338], '×': [2339, 2645, 3186, 3251, 3264, 3943], '105/ml': [2340], '100-mm': [2342], 'culture': [2343], 'dishes': [2344], 'presence': [2347, 2635, 3003], 'absence': [2349, 3005], '100': [2353, 2408, 2424, 3815], 'ng/ml': [2354, 2361, 2409], 'factor-I': [2357], '(IGF-I),': [2358], '50': [2360, 2420, 2758, 2768, 3135, 3146, 3166, 3292, 3573], '(FGF-2)': [2366], 'indicated': [2369, 3838], 'cultured': [2372, 2468, 3771], 'up': [2374], '72': [2376, 3650, 3777], 'h': [2377, 3175, 3577, 3651, 3762, 3778, 3835, 3845], 'medium.': [2383], 'Generation': [2384], 'Cells—MIA': [2387], 'depleted': [2391], '(mtDNA)': [2395], 'incubating': [2399], 'wild': [2400], 'type': [2401], '(Rho+)': [2403], '6–8': [2405], 'weeks': [2406], 'ethidium': [2410, 2475], 'bromide.': [2411, 2476], '4.5': [2417], 'mg/ml': [2418], 'glucose,': [2419], 'μg/ml': [2421, 2425], 'uridine,': [2422], 'pyruvate': [2426], 'compensate': [2428], 'respiratory': [2431], 'metabolism': [2432], 'deficit': [2433], 'previously': [2435, 3339, 3494, 4106], 'described': [2436, 2704, 2864, 3338, 3427, 3493, 3692, 3905, 3998, 4105], '(34King': [2437], 'Attardi': [2439], 'Science.': [2441], '1989;': [2442], '246:': [2443], '500-503Crossref': [2444], '(1465)': [2447], '35King': [2450], 'Methods': [2452], 'Enzymol.': [2453], '264:': [2455], '339-344Crossref': [2456], 'After': [2460], 'selection,': [2461], 'specified': [2472, 3781], 'without': [2474, 2669], 'To': [2477, 2974, 3308, 3559], 'verify': [2478], 'mtDNA': [2480, 2496], 'depletion,': [2481], 'total': [2482, 2690, 3383, 3414], 'extracted': [2486], 'subjected': [2488, 3417], 'PCR': [2490, 3419], 'using': [2491, 2700, 3401, 3556, 3588, 3619, 3670, 3868, 3991, 4082, 4151], 'two': [2492], 'pairs': [2493], 'specific': [2497], 'primers:': [2498], '1)': [2499], 'Mts1': [2500], '(forward)': [2501, 2515], '(5′-cctagggataacagcgcaat)': [2502], 'Mtas1': [2504], '(reverse)': [2505, 2519], '(5′-tagaagagcgatggtgagag),': [2506], 'gave': [2508, 2522], '630-bp': [2510], 'product,': [2511], '2)': [2513], 'Mts2': [2514], '(5′-aacatacccatggccaacct)': [2516], 'Mtas2': [2518], '(5′-ggcaggagtaatcagaggtg),': [2520], '532-bp': [2524], 'product': [2525], '(36Hail': [2526], 'Youssef': [2529], 'E.M.': [2530], 'Lotan': [2531], '61:': [2536], '6698-6702PubMed': [2537], '37Park': [2540], 'K.S.': [2541], 'Nam': [2542, 3499, 3911, 4004, 4111], 'K.J.': [2543, 3500, 3912, 4005, 4112], 'Kim': [2544], 'J.W.': [2545], 'Lee': [2546, 2552], 'Y.B.': [2547], 'Han': [2548], 'C.Y.': [2549], 'Jeong': [2550], 'J.K.': [2551], 'H.K.': [2553], 'Pak': [2554], 'Y.K.': [2555], '280:': [2560], 'E1007-E1014PubMed': [2561], 'control,': [2565], 'expression': [2569, 3659], 'β-actin,': [2571], 'coded': [2574], 'chromosomal': [2576], 'DNA.': [2577], 'Measurement': [2578, 2681, 3472], 'Intracellular': [2580, 4169], 'Levels—Intracellular': [2582], 'levels': [2584], 'flow': [2588, 3975], 'cytometry': [2589], 'loaded': [2592, 3532], 'dye': [2596], 'DCFH-DA': [2597, 2615], '(38Royall': [2598], 'Ischiropoulos': [2600], '1993;': [2605], '302:': [2606], '348-355Crossref': [2607], '(1050)': [2610], 'nonfluorescent': [2614], 'readily': [2616], 'diffuses': [2617], 'into': [2618, 4091], 'cells,': [2620], 'where': [2621], 'it': [2622], 'hydrolyzed': [2624], 'polar': [2627], 'derivative': [2628], 'DCFH,': [2629], 'oxidized': [2632], 'fluorescent': [2641, 3644, 4064], 'DCF.': [2642], 'Approximately': [2643], '1': [2644, 2773, 2803, 3174, 3216, 3219, 3306, 3576, 3844, 3942, 3958], '106': [2646, 3944], 'incubated': [2649, 3155, 3832, 3962, 4033], 'dark': [2652, 3965], '30': [2654, 2855, 3231, 3267, 3524, 3538, 3967], 'min': [2655, 2804, 2856, 3183, 3232, 3525, 3539, 3968], '10': [2660, 3182, 3213, 3534, 4035, 4051], 'μm': [2661, 2818, 2999, 3028, 3044, 3049, 3097, 3147, 4036], 'harvested,': [2663], 'resuspended': [2665, 3202, 3937], 'DCFH-DA.': [2670], 'Fluorescence': [2671, 4072], 'recorded': [2673], 'FL-1': [2675], 'channel': [2676], 'FACScan®': [2678, 3555], '(Becton': [2679], 'Dickinson).': [2680], 'Oxidase': [2684], 'Activity—Superoxide': [2685], 'homogenates': [2692, 2991], 'fractions': [2698, 3318], 'lucigenin-derived': [2701], 'chemiluminescence': [2702, 2788, 3020, 3114], 'Refs.': [2706], '39Rajagopalan': [2707], 'Kurz': [2709], 'Munzel': [2711], 'Tarpey': [2713], 'Freeman': [2715], 'B.A.': [2716], 'Harrison': [2719, 2741], 'D.G.': [2720, 2742], 'Clin.': [2722], 'Invest.': [2723], '97:': [2725], '1916-1923Crossref': [2726], '(2165)': [2729], 'Scholar': [2731], '40Sorescu': [2733], 'Somers': [2735], 'M.J.': [2736], 'Grant': [2739], 'Free': [2745, 2929, 3080], 'Radic.': [2746, 2930, 3081], '30:': [2750], '603-612Crossref': [2751], '(91)': [2754], 'Scholar.': [2756, 3735], 'Briefly,': [2757, 3382], 'μg': [2759, 3412, 3621, 4029], 'protein': [2761, 2876, 3645, 3663], 'diluted': [2763], '500': [2765, 3947], 'μl': [2766, 3628, 3948, 3954], 'phosphate': [2770], 'buffer': [2771, 3159, 3206, 3288, 3951, 4041], 'EGTA': [2775], '150': [2777, 3163], 'sucrose.': [2779], 'Dark-adapted': [2780], 'lucigenin': [2781, 2945, 3000, 3011, 3050, 3098, 3120], 'added': [2783], 'sample,': [2786], 'measurement': [2789, 2828], 'immediately': [2791], 'started.': [2792], 'Chemiluminescence': [2793, 2986], '(in': [2794], 'arbitrary': [2795], 'units)': [2796], '15-s': [2800], 'intervals': [2801], 'Turner': [2807], '20/20': [2808], 'luminometer': [2809], '(Turner': [2810], 'Designs,': [2811], 'Sunnyvale,': [2812], 'NADPH': [2814, 3007, 3022], 'NADH': [2816, 2958], '(100': [2817], 'each)': [2819], 'substrates.': [2823], 'specificity': [2825], 'confirmed': [2830], 'adding': [2832], 'either': [2833], 'nonenzymatic': [2835], 'scavenger,': [2837], '(10': [2839], 'mm),': [2840], 'dismutase': [2843], '(200': [2844], 'units/ml;': [2845], 'Sigma).': [2846], 'experiments,': [2849], 'homogenate': [2851], 'preincubated': [2853], 'legend': [2867], 'Fig.': [2869, 3449], '3.': [2870], 'assays,': [2875], 'concentration': [2877], 'Bradford': [2882], 'assay': [2883, 3986], '(Bio-Rad).': [2884], 'It': [2885], 'has': [2886], '(41Li': [2889], 'Zhu': [2891], 'Kuppusamy': [2893], 'Roubaud': [2895], 'V.': [2896, 3347, 3366], 'Zweier': [2897, 2925, 3076], 'J.L.': [2898, 2926, 3077], 'Trush': [2899], 'M.A.': [2900, 2924, 3075], '1998;': [2904, 3353], '273:': [2905], '2015-2023Abstract': [2906], '(480)': [2914], '42Janiszewski': [2917, 3068], 'Souza': [2919, 3070], 'H.P.': [2920, 3071], 'Liu': [2921, 3072], 'Pedro': [2923, 3074], 'Laurindo': [2927, 3078], 'F.R.': [2928, 3079], '32:': [2934, 3085], '446-453Crossref': [2935, 3086], '(62)': [2938, 3089], 'itself': [2948], 'additional': [2950, 3774], 'production,': [2952], 'especially': [2955], 'pronounced': [2956], 'substrate.': [2961], 'result': [2964], 'overestimation': [2966], 'homogenate.': [2973], 'exclude': [2975], 'artificial': [2977, 3103], 'lucigenin,': [2980, 3029], 'performed': [2982, 3587], 'following': [2984], 'experiments.': [2985, 4146], '5,': [2993], '25,': [2994], '50,': [2995], '100,': [2996], '200': [2998], 'NADH.': [3009, 3025], 'At': [3010, 3647], 'concentrations': [3012, 3121], '5–50': [3013, 3043, 3096, 3122], 'μm,': [3014], 'much': [3018], 'higher': [3019], 'With': [3026], '100–200': [3027, 3048], 'NADH-induced': [3030], 'became': [3032], 'larger': [3033], 'those': [3035], 'induced': [3036], 'NADPH.': [3038], 'responses': [3040], 'blocked': [3052, 3804], 'NAD(P)H-dependent': [3058], 'oxidases.': [3059], 'accord': [3061], 'presented': [3065, 3140], 'Ref.': [3067, 3694], 'does': [3099], 'induce': [3101], 'O2−˙': [3104], 'kinetics': [3111], 'response': [3115], 'same': [3118], 'μm;': [3123], 'magnitude': [3126], 'greater': [3131], '25': [3133, 3144], 'μm.': [3136], 'Thus,': [3137], 'lucigenin.': [3148], 'Preparation': [3149], 'Total': [3151], 'Lysates—Cells': [3153], 'lysis': [3158, 3205], '(0.5': [3160], 'EDTA,': [3162], 'NaCl,': [3165, 3291, 3817], 'Tris,': [3167, 3294], '0.5%': [3168], 'Nonidet': [3169], 'P-40,': [3170], 'pH': [3171, 3225, 3303, 3818], '7.5)': [3172], 'centrifuged': [3180, 3248, 3261], '13,000': [3185, 3263], 'g,': [3187], 'supernatants': [3189], 'collected': [3191, 3935], 'stored': [3193], '–80': [3195], 'until': [3197], 'assayed.': [3198], 'Fractionation—Cells': [3200], '(250': [3207], 'sucrose,': [3209, 4048], '20': [3210, 3627, 3829], 'HEPES,': [3212], 'KCl,': [3215], 'Na-EGTA,': [3218], 'Na-EDTA,': [3221], '2': [3222, 3834, 3953], 'MgCl2,': [3224], '7.0),': [3226], 'allowed': [3227], 'swell': [3229], '°C,': [3235], 'then': [3237, 3842], 'disrupted': [3238], '80': [3240], 'strokes': [3241], 'Dounce': [3244], 'homogenizer.': [3245], 'Homogenates': [3246], '1,000': [3250], 'g': [3252, 3265], 'pellet': [3254, 3277], 'nuclei': [3255], 'debris.': [3258], 'Supernatants': [3259], 'min,': [3268], 'fraction': [3272], '(supernatant)': [3273], 'collected.': [3275], '(heavy': [3278], 'membranes': [3279], 'enriched': [3280], 'mitochondria)': [3282], 'lysed': [3284], 'radioimmune': [3286], 'precipitation': [3287], '(0.15': [3289], 'm': [3290], '1%': [3295, 3298], 'deoxycholic': [3296], 'acid,': [3297], 'Triton': [3299], 'X-100,': [3300], '0.1%': [3301, 4049], 'SDS,': [3302], '7.2)': [3304], 'h.': [3307], 'validate': [3309], 'quality': [3311], 'separation,': [3316], 'assessed': [3320, 3638], 'immunoblotting': [3322], 'marker': [3326], 'IV.': [3331], 'Reverse': [3332], 'Transcription-PCR—The': [3333], 'procedures': [3334], '(43Gukovsky': [3340], 'Blinman': [3344], 'T.A.': [3345, 3360], 'Zaninovic': [3346, 3365], '275:': [3354], 'G1402-G1414Crossref': [3355], '44Blinman': [3359], 'Gukovsky': [3361, 3501, 3913, 4006, 4113], 'Mouria': [3363], 'Livingston': [3367], 'C1993-C2003Crossref': [3378], 'RNA': [3384, 3415], 'TRI': [3392], 'reagent': [3393, 3592], '(Molecular': [3394], 'Research': [3395], 'Center,': [3396], 'Cincinnati,': [3397], 'OH)': [3398], 'reverse-transcribed': [3400], 'SuperScript': [3403], 'II': [3404], 'preamplification': [3405], 'kit': [3406, 3874, 3898], '(Invitrogen).': [3407, 3593], 'cDNA': [3408], 'derived': [3409], '0.5': [3411], 'gene-specific,': [3422], 'intron-spanning': [3423], 'primers': [3424], 'Table': [3429], 'Target': [3431], 'sequences': [3432, 3452], 'amplified': [3434], '56–58': [3436], '°C.': [3437, 4056], 'reverse': [3439], 'transcription-PCR': [3440], 'products': [3441], 'expected': [3446], 'size': [3447], '(see': [3448], '5).Table': [3450], 'IPrimer': [3451], 'subunitsmRNAForward': [3456], 'primerReverse': [3457], 'primerExpected': [3458], 'sizeGenBank™': [3459], 'accession': [3460], 'no.bpNox15′-acaaattccagtgtgcagaccac5′-agactggaatatcggtgacagca247AJ438989gp91phox': [3461], '(Nox2)5′-gggctgttcaatgcttgtggct5′-acatctttctcctcatcatggtgc413NM_000397Nox': [3462], '35′-atgaacacctctggggtcagctga5′-ggatcggagtcactcccttcgctg458NM_015718Nox': [3463], '45′-ctcagcggaatcaatcagctgtg5′-agaggaacacgacaatcagccttag286NM_016931Nox': [3464], '55′-atcaagcggccccctttttttcac5′-ctcattgtcacactcctcgacagc630AF317889p22phox5′-gtgtttgtgtgcctgctggagt5′-ctgggcggctgcttgatggt320M21186p47phox5′-gtacccagccagcactatgtgt5′-aaagtagcctgtgacgtcgtct771NM_000265p67phox5′-ttcgagggaaccagctgataga5′-gcatgggaacactgagcttcac760M32011β-Actin5′-atgggtcagaaggattcctatgt5′-gaaggtctcaaacatgatctggg243NM_001101': [3465], 'Open': [3466], 'table': [3467], 'new': [3470], 'tab': [3471], 'Mitochondrial': [3474], 'Membrane': [3475], 'Potential': [3476], '(Δψm)—Changes': [3477], 'Δψm': [3479], 'potential-sensitive': [3484], 'probe': [3485, 4186], 'Red': [3487], '(CMX-Ros;': [3488], 'Probes),': [3490], '(45Vaquero': [3495, 3907, 4000, 4107], 'E.C.': [3496, 3908, 4001, 4108], 'Edderkaoui': [3497, 3909, 4002, 4109], 'Gastroenterology.': [3507, 3919, 4012, 4119], '125:': [3509, 3921, 4014, 4121], '1188-1202Abstract': [3510, 3922, 4015, 4122], '(69)': [3518, 3930, 4023, 4130], 'During': [3521], 'last': [3523], 'incubation': [3528], 'period,': [3529], 'nm': [3535], 'CMX-Ros': [3536, 3579], 'dark,': [3545], 'washed': [3546, 3822], 'twice': [3547], 'phosphate-buffered': [3549], 'saline,': [3550], 'analyzed': [3552, 3893, 3973], 'FL-3': [3557], 'detector.': [3558], 'completely': [3560], 'dissipate': [3561], 'Δψm,': [3562], 'treated': [3565], 'uncoupling': [3568], 'agent': [3569], 'fluorocyanide': [3570], 'm-chlorophenylhydrazone': [3571], '(FCCP;': [3572], 'μm)': [3574], 'before': [3578, 3779, 3906, 3999], 'staining.': [3580], 'Transfections—Transient': [3581], 'transfection': [3582], 'LipofectAMINE': [3590, 3630], '2000': [3591], 'pcDNA3-MnSOD': [3595], 'plasmid': [3596, 3624], 'kindly': [3598], 'provided': [3599], 'Larry': [3602], '(University': [3605], 'Iowa,': [3607], 'Iowa': [3608], 'City,': [3609], 'IA).': [3610], 'done': [3613, 3690, 4150], 'according': [3614, 3878], "manufacturer's": [3617, 3881], 'instructions,': [3618], '5–8': [3620], '60-mm': [3633, 3749], 'dish.': [3634, 3750], 'efficiency': [3636], 'co-transfection': [3640], 'green': [3643], 'plasmid.': [3646], '48': [3648, 3775], 'post-transfection,': [3652, 3763], 'lysates': [3654, 3788, 3990], 'collected,': [3656], 'Western': [3667, 3783, 4097], 'blot': [3668, 4098], 'analysis': [3669, 4099, 4148], 'polyclonal': [3672], 'Biotechnology.': [3677], '1.5': [3736], 'nmol': [3737], 'phosphorthioate': [3742], 'oligonucleotide,': [3743, 3754], '5′-AGCTCCTCCAGGACACAGCC,': [3744], 'applied': [3746], 'scrambled': [3753], '5′-TCGAGGAGGTCCTGTGTCGG,': [3755], 'control.': [3760], '6': [3761], 'fresh': [3764], 'supplied,': [3767], 'analyses.': [3782], 'Blot': [3784], 'Analysis—Proteins': [3785], 'separated': [3790], '4–20%': [3792], 'SDS-PAGE': [3793], '(Invitrogen)': [3794], 'electrophoretically': [3796], 'transferred': [3797], 'nitrocellulose': [3799], 'membranes.': [3800], 'Nonspecific': [3801], 'binding': [3802, 3950], 'milk': [3807], 'Tris-buffered': [3809, 3824], 'saline': [3810, 3825], '(4': [3811], 'Tris': [3813], 'base,': [3814], '7.5).': [3819], 'Membranes': [3820], '0.05%': [3827], 'Tween': [3828], '(TTBS)': [3830], 'primary': [3839], 'antibodies': [3840], 'horseradish': [3847], 'peroxidase-conjugated': [3848], 'secondary': [3849], 'antibody.': [3850], 'Blots': [3851], 'developed': [3853], 'Supersignal': [3856], 'Chemiluminescent': [3857], 'Substrate': [3858], '(Pierce).': [3859], 'Measurements': [3860], 'Apoptosis—Internucleosomal': [3862], 'fragmentation': [3864], 'Death': [3871], 'Detection': [3872], 'ELISAPlus': [3873], '(Roche': [3875], 'Applied': [3876, 3901], 'Science)': [3877], 'instructions.': [3882], 'Absorbance': [3883], 'values': [3884], 'normalized': [3886], 'number.': [3889], 'Phosphatidylserine': [3890], 'externalization': [3891], 'annexin-V-FLUOS': [3896], 'staining': [3897], 'Roche': [3900], 'Science': [3902], 'annexin-V': [3956], 'μlof': [3959], 'propidium': [3960], 'iodide,': [3961], 'room': [3970], 'temperature,': [3971], 'cytometry.': [3976], 'Effector': [3977], '(DEVDase)': [3979], 'fluorogenic': [3985], 'whole': [3988], 'substrate,': [3995], 'lysate': [4027], '(50–100': [4028], 'protein)': [4031], 'substrate': [4037, 4058], 'reaction': [4040], '(25': [4042], 'HEPES': [4044], '(pH': [4045], '7.5),': [4046], '10%': [4047], 'dithiothreitol)': [4053], 'Caspase': [4057], 'cleavage': [4059], 'releases': [4060], 'emits': [4063], '380-nm': [4067], 'excitation': [4068], '440-nm': [4070], 'emission.': [4071], 'Shimadzu': [4077], 'RF-1501': [4078], 'spectrofluorimeter': [4079], 'calibrated': [4081], 'standard': [4084], 'curve': [4085], 'AMC.': [4087], 'Cytochrome': [4088], 'release': [4090], 'cytosol': [4093], 'assayed': [4095], 'fractions,': [4102], 'Statistical': [4133, 4147], 'Analysis—Results': [4134], 'expressed': [4136], 'means': [4138], '±': [4139], 'S.E.': [4140], 'least': [4143], 'three': [4144], 'independent': [4145], 'unpaired': [4152], "Student's": [4153], 't': [4154], 'test.': [4155], 'value': [4157], 'p': [4159], '<': [4160], '0.05': [4161], 'considered': [4163], 'statistically': [4164], 'significant.': [4165], 'Factors': [4167], 'Stimulate': [4168], 'Production': [4171], 'Carcinoma': [4178], 'Flavoprotein-dependent': [4181], 'Oxidase—Using': [4182], 'fluorescence': [4185], 'determined': [4189], 'lines': [4200], '(Fig.': [4201, 4207, 4215], '1).': [4202], '1,': [4208], 'C–E)': [4211], '1B),': [4216]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2124413979', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 10}, {'year': 2021, 'cited_by_count': 18}, {'year': 2020, 'cited_by_count': 12}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 21}, {'year': 2017, 'cited_by_count': 18}, {'year': 2016, 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