Title: Th1/Th2 balance of peripheral T helper cells in systemic lupus erythematosus
Abstract: Arthritis & RheumatismVolume 42, Issue 8 p. 1644-1648 Basic ScienceFree to Read Th1/Th2 balance of peripheral T helper cells in systemic lupus erythematosus Mitsuteru Akahoshi, Mitsuteru Akahoshi Kyushu University Medical School, Fukuoka, Japan; Tsutomu Kohsaka: Otsuka Tokyo Assay Laboratories, Tokyo, JapanSearch for more papers by this authorHitoshi Nakashima, Corresponding Author Hitoshi Nakashima Kyushu University Medical School, Fukuoka, Japan; Tsutomu Kohsaka: Otsuka Tokyo Assay Laboratories, Tokyo, JapanFirst Department of Internal Medicine, Kyushu University Medical School, Fukuoka 812-8582, JapanSearch for more papers by this authorYosuke Tanaka, Yosuke Tanaka Kyushu University Medical School, Fukuoka, Japan; Tsutomu Kohsaka: Otsuka Tokyo Assay Laboratories, Tokyo, JapanSearch for more papers by this authorTsutomu Kohsaka, Tsutomu Kohsaka Kyushu University Medical School, Fukuoka, Japan; Tsutomu Kohsaka: Otsuka Tokyo Assay Laboratories, Tokyo, JapanSearch for more papers by this authorShuji Nagano, Shuji Nagano Kyushu University Medical School, Fukuoka, Japan; Tsutomu Kohsaka: Otsuka Tokyo Assay Laboratories, Tokyo, JapanSearch for more papers by this authorEiichi Ohgami, Eiichi Ohgami Kyushu University Medical School, Fukuoka, Japan; Tsutomu Kohsaka: Otsuka Tokyo Assay Laboratories, Tokyo, JapanSearch for more papers by this authorYojiro Arinobu, Yojiro Arinobu Kyushu University Medical School, Fukuoka, Japan; Tsutomu Kohsaka: Otsuka Tokyo Assay Laboratories, Tokyo, JapanSearch for more papers by this authorKunihiro Yamaoka, Kunihiro Yamaoka Kyushu University Medical School, Fukuoka, Japan; Tsutomu Kohsaka: Otsuka Tokyo Assay Laboratories, Tokyo, JapanSearch for more papers by this authorHiroaki Niiro, Hiroaki Niiro Kyushu University Medical School, Fukuoka, Japan; Tsutomu Kohsaka: Otsuka Tokyo Assay Laboratories, Tokyo, JapanSearch for more papers by this authorMichiya Shinozaki, Michiya Shinozaki Kyushu University Medical School, Fukuoka, Japan; Tsutomu Kohsaka: Otsuka Tokyo Assay Laboratories, Tokyo, JapanSearch for more papers by this authorHideki Hirakata, Hideki Hirakata Kyushu University Medical School, Fukuoka, Japan; Tsutomu Kohsaka: Otsuka Tokyo Assay Laboratories, Tokyo, JapanSearch for more papers by this authorTakahiko Horiuchi, Takahiko Horiuchi Kyushu University Medical School, Fukuoka, Japan; Tsutomu Kohsaka: Otsuka Tokyo Assay Laboratories, Tokyo, JapanSearch for more papers by this authorTakeshi Otsuka, Takeshi Otsuka Kyushu University Medical School, Fukuoka, Japan; Tsutomu Kohsaka: Otsuka Tokyo Assay Laboratories, Tokyo, JapanSearch for more papers by this authorYoshiyuki Niho, Yoshiyuki Niho Kyushu University Medical School, Fukuoka, Japan; Tsutomu Kohsaka: Otsuka Tokyo Assay Laboratories, Tokyo, JapanSearch for more papers by this author Mitsuteru Akahoshi, Mitsuteru Akahoshi Kyushu University Medical School, Fukuoka, Japan; Tsutomu Kohsaka: Otsuka Tokyo Assay Laboratories, Tokyo, JapanSearch for more papers by this authorHitoshi Nakashima, Corresponding Author Hitoshi Nakashima Kyushu University Medical School, Fukuoka, Japan; Tsutomu Kohsaka: Otsuka Tokyo Assay Laboratories, Tokyo, JapanFirst Department of Internal Medicine, Kyushu University Medical School, Fukuoka 812-8582, JapanSearch for more papers by this authorYosuke Tanaka, Yosuke Tanaka Kyushu University Medical School, Fukuoka, Japan; Tsutomu Kohsaka: Otsuka Tokyo Assay Laboratories, Tokyo, JapanSearch for more papers by this authorTsutomu Kohsaka, Tsutomu Kohsaka Kyushu University Medical School, Fukuoka, Japan; Tsutomu Kohsaka: Otsuka Tokyo Assay Laboratories, Tokyo, JapanSearch for more papers by this authorShuji Nagano, Shuji Nagano Kyushu University Medical School, Fukuoka, Japan; Tsutomu Kohsaka: Otsuka Tokyo Assay Laboratories, Tokyo, JapanSearch for more papers by this authorEiichi Ohgami, Eiichi Ohgami Kyushu University Medical School, Fukuoka, Japan; Tsutomu Kohsaka: Otsuka Tokyo Assay Laboratories, Tokyo, JapanSearch for more papers by this authorYojiro Arinobu, Yojiro Arinobu Kyushu University Medical School, Fukuoka, Japan; Tsutomu Kohsaka: Otsuka Tokyo Assay Laboratories, Tokyo, JapanSearch for more papers by this authorKunihiro Yamaoka, Kunihiro Yamaoka Kyushu University Medical School, Fukuoka, Japan; Tsutomu Kohsaka: Otsuka Tokyo Assay Laboratories, Tokyo, JapanSearch for more papers by this authorHiroaki Niiro, Hiroaki Niiro Kyushu University Medical School, Fukuoka, Japan; Tsutomu Kohsaka: Otsuka Tokyo Assay Laboratories, Tokyo, JapanSearch for more papers by this authorMichiya Shinozaki, Michiya Shinozaki Kyushu University Medical School, Fukuoka, Japan; Tsutomu Kohsaka: Otsuka Tokyo Assay Laboratories, Tokyo, JapanSearch for more papers by this authorHideki Hirakata, Hideki Hirakata Kyushu University Medical School, Fukuoka, Japan; Tsutomu Kohsaka: Otsuka Tokyo Assay Laboratories, Tokyo, JapanSearch for more papers by this authorTakahiko Horiuchi, Takahiko Horiuchi Kyushu University Medical School, Fukuoka, Japan; Tsutomu Kohsaka: Otsuka Tokyo Assay Laboratories, Tokyo, JapanSearch for more papers by this authorTakeshi Otsuka, Takeshi Otsuka Kyushu University Medical School, Fukuoka, Japan; Tsutomu Kohsaka: Otsuka Tokyo Assay Laboratories, Tokyo, JapanSearch for more papers by this authorYoshiyuki Niho, Yoshiyuki Niho Kyushu University Medical School, Fukuoka, Japan; Tsutomu Kohsaka: Otsuka Tokyo Assay Laboratories, Tokyo, JapanSearch for more papers by this author First published: 26 April 2001 https://doi.org/10.1002/1529-0131(199908)42:8<1644::AID-ANR12>3.0.CO;2-LCitations: 181AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Objective To analyze the Th1/Th2 balance of peripheral Th cells in patients with systemic lupus erythematosus (SLE). Methods The Th1:Th2 ratio was analyzed in 3 groups: SLE without proteinuria (group I; n = 23), SLE with proteinuria (group II; n = 31), and normal controls (group III; n = 24). Group II patients who had undergone renal biopsy were classified into 3 subgroups based on their renal histopathologic findings. The intracellular cytokine detection method with flow cytometry was used to quantitate Th1 and Th2 cells. Results There was no difference in the mean Th1:Th2 ratio between SLE patients (groups I and II) and healthy controls (group III). However, the mean value in group II was significantly higher than those in groups I and III. Moreover, within group II, the mean value in SLE patients who had diffuse proliferative lupus nephritis (World Health Organization class IV) was especially high. Conclusion Although SLE has been considered to be a disease in which Th2 cells predominate, the Th1/Th2 balance of peripheral Th cells in SLE patients in the present study did not show a predominance of these cells. In contrast, among SLE patients with WHO class IV lupus nephritis, there was a strong predominance of Th1. Citing Literature Volume42, Issue8August 1999Pages 1644-1648 RelatedInformation
Publication Year: 1999
Publication Date: 1999-08-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 284
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