Publication Information

{'id': 'https://openalex.org/W2124261208', 'doi': 'https://doi.org/10.1242/jcs.02738', 'title': 'E-cadherin loss promotes the initiation of squamous cell carcinoma invasion through modulation of integrin-mediated adhesion', 'display_name': 'E-cadherin loss promotes the initiation of squamous cell carcinoma invasion through modulation of integrin-mediated adhesion', 'publication_year': 2006, 'publication_date': '2006-01-04', 'ids': {'openalex': 'https://openalex.org/W2124261208', 'doi': 'https://doi.org/10.1242/jcs.02738', 'mag': '2124261208', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16390868'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1242/jcs.02738', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S5677253', 'display_name': 'Journal of Cell Science', 'issn_l': '0021-9533', 'issn': ['0021-9533', '1477-9137'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'http://jcs.biologists.org/content/119/2/283.full.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5018229542', 'display_name': 'Weitian Zhang', 'orcid': 'https://orcid.org/0009-0004-9263-4226'}, 'institutions': [{'id': 'https://openalex.org/I121934306', 'display_name': 'Tufts University', 'ror': 'https://ror.org/05wvpxv85', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I121934306']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Weitian Zhang', 'raw_affiliation_strings': ['Division of Cancer Biology and Tissue Engineering, Department of Oral and Maxillofacial Pathology, School of Dental Medicine, Tufts University, 55 Kneeland Street, Boston, MA 02111, USA.'], 'affiliations': [{'raw_affiliation_string': 'Division of Cancer Biology and Tissue Engineering, Department of Oral and Maxillofacial Pathology, School of Dental Medicine, Tufts University, 55 Kneeland Street, Boston, MA 02111, USA.', 'institution_ids': ['https://openalex.org/I121934306']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072817167', 'display_name': 'Addy Alt‐Holland', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I121934306', 'display_name': 'Tufts University', 'ror': 'https://ror.org/05wvpxv85', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I121934306']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Addy Alt-Holland', 'raw_affiliation_strings': ['Division of Cancer Biology and Tissue Engineering, Department of Oral and Maxillofacial Pathology, School of Dental Medicine, Tufts University, 55 Kneeland Street, Boston, MA 02111, USA.'], 'affiliations': [{'raw_affiliation_string': 'Division of Cancer Biology and Tissue Engineering, Department of Oral and Maxillofacial Pathology, School of Dental Medicine, Tufts University, 55 Kneeland Street, Boston, MA 02111, USA.', 'institution_ids': ['https://openalex.org/I121934306']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003951879', 'display_name': 'Alexander R. Margulis', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I121934306', 'display_name': 'Tufts University', 'ror': 'https://ror.org/05wvpxv85', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I121934306']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alexander Margulis', 'raw_affiliation_strings': ['Division of Cancer Biology and Tissue Engineering, Department of Oral and Maxillofacial Pathology, School of Dental Medicine, Tufts University, 55 Kneeland Street, Boston, MA 02111, USA.'], 'affiliations': [{'raw_affiliation_string': 'Division of Cancer Biology and Tissue Engineering, Department of Oral and Maxillofacial Pathology, School of Dental Medicine, Tufts University, 55 Kneeland Street, Boston, MA 02111, USA.', 'institution_ids': ['https://openalex.org/I121934306']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044961799', 'display_name': 'Yulia Shamis', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I121934306', 'display_name': 'Tufts University', 'ror': 'https://ror.org/05wvpxv85', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I121934306']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yulia Shamis', 'raw_affiliation_strings': ['Division of Cancer Biology and Tissue Engineering, Department of Oral and Maxillofacial Pathology, School of Dental Medicine, Tufts University, 55 Kneeland Street, Boston, MA 02111, USA.'], 'affiliations': [{'raw_affiliation_string': 'Division of Cancer Biology and Tissue Engineering, Department of Oral and Maxillofacial Pathology, School of Dental Medicine, Tufts University, 55 Kneeland Street, Boston, MA 02111, USA.', 'institution_ids': ['https://openalex.org/I121934306']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068941302', 'display_name': 'Norbert E. Fusenig', 'orcid': 'https://orcid.org/0000-0002-8834-6502'}, 'institutions': [{'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}, {'id': 'https://openalex.org/I17937529', 'display_name': 'German Cancer Research Center', 'ror': 'https://ror.org/04cdgtt98', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I17937529']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Norbert E. Fusenig', 'raw_affiliation_strings': ['German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany'], 'affiliations': [{'raw_affiliation_string': 'German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany', 'institution_ids': ['https://openalex.org/I223822909', 'https://openalex.org/I17937529']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047513658', 'display_name': 'Ulrich Rodeck', 'orcid': 'https://orcid.org/0000-0002-0174-6125'}, 'institutions': [{'id': 'https://openalex.org/I149251103', 'display_name': 'Thomas Jefferson University', 'ror': 'https://ror.org/00ysqcn41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I149251103']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ulrich Rodeck', 'raw_affiliation_strings': ['Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA', 'institution_ids': ['https://openalex.org/I149251103']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5030374908', 'display_name': 'William P. Meehan', 'orcid': 'https://orcid.org/0009-0004-6334-051X'}, 'institutions': [{'id': 'https://openalex.org/I121934306', 'display_name': 'Tufts University', 'ror': 'https://ror.org/05wvpxv85', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I121934306']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jonathan A. Garlick', 'raw_affiliation_strings': ['Division of Cancer Biology and Tissue Engineering, Department of Oral and Maxillofacial Pathology, School of Dental Medicine, Tufts University, 55 Kneeland Street, Boston, MA 02111, USA.'], 'affiliations': [{'raw_affiliation_string': 'Division of Cancer Biology and Tissue Engineering, Department of Oral and Maxillofacial Pathology, School of Dental Medicine, Tufts University, 55 Kneeland Street, Boston, MA 02111, USA.', 'institution_ids': ['https://openalex.org/I121934306']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.115, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 55, 'citation_normalized_percentile': {'value': 0.844285, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '119', 'issue': '2', 'first_page': '283', 'last_page': '291'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10929', 'display_name': 'Wnt Signaling in Development and Disease', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10929', 'display_name': 'Wnt Signaling in Development and Disease', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10831', 'display_name': 'Integrin Signaling in Inflammation and Cancer', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10379', 'display_name': 'Cell Mechanics and Extracellular Matrix Interactions', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/extracellular-matrix', 'display_name': 'Extracellular Matrix', 'score': 0.504984}, {'id': 'https://openalex.org/keywords/cell–cell-interaction', 'display_name': 'Cell–cell interaction', 'score': 0.43664056}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7908944}, {'id': 'https://openalex.org/C195687474', 'wikidata': 'https://www.wikidata.org/wiki/Q409715', 'display_name': 'Integrin', 'level': 3, 'score': 0.7068357}, {'id': 'https://openalex.org/C149402561', 'wikidata': 'https://www.wikidata.org/wiki/Q24776048', 'display_name': 'Cadherin', 'level': 3, 'score': 0.6953083}, {'id': 'https://openalex.org/C85789140', 'wikidata': 'https://www.wikidata.org/wiki/Q187640', 'display_name': 'Cell adhesion', 'level': 3, 'score': 0.61323}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5936157}, {'id': 'https://openalex.org/C2779814568', 'wikidata': 'https://www.wikidata.org/wiki/Q58345', 'display_name': 'Laminin', 'level': 3, 'score': 0.59097564}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.54503506}, {'id': 'https://openalex.org/C16930146', 'wikidata': 'https://www.wikidata.org/wiki/Q4381253', 'display_name': 'Stromal cell', 'level': 2, 'score': 0.51561254}, {'id': 'https://openalex.org/C2911091166', 'wikidata': 'https://www.wikidata.org/wiki/Q106419912', 'display_name': 'Transplantation', 'level': 2, 'score': 0.508761}, {'id': 'https://openalex.org/C16224149', 'wikidata': 'https://www.wikidata.org/wiki/Q187637', 'display_name': 'Cell adhesion molecule', 'level': 2, 'score': 0.508561}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.45902213}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.4387016}, {'id': 'https://openalex.org/C183521119', 'wikidata': 'https://www.wikidata.org/wiki/Q5058397', 'display_name': 'Cell–cell interaction', 'level': 3, 'score': 0.43664056}, {'id': 'https://openalex.org/C189165786', 'wikidata': 'https://www.wikidata.org/wiki/Q193825', 'display_name': 'Extracellular matrix', 'level': 2, 'score': 0.40938383}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.37166542}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.34055692}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.06815031}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.068012565}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D015820', 'descriptor_name': 'Cadherins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002294', 'descriptor_name': 'Carcinoma, Squamous Cell', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D002448', 'descriptor_name': 'Cell Adhesion', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D002471', 'descriptor_name': 'Cell Transformation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D039421', 'descriptor_name': 'Integrin alpha2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D039422', 'descriptor_name': 'Integrin alpha3', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019012', 'descriptor_name': 'Integrin beta1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015820', 'descriptor_name': 'Cadherins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015820', 'descriptor_name': 'Cadherins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002294', 'descriptor_name': 'Carcinoma, Squamous Cell', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002294', 'descriptor_name': 'Carcinoma, Squamous Cell', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D002448', 'descriptor_name': 'Cell Adhesion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018929', 'descriptor_name': 'Cell Culture Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017690', 'descriptor_name': 'Cell Transplantation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005109', 'descriptor_name': 'Extracellular Matrix', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005109', 'descriptor_name': 'Extracellular Matrix', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D039421', 'descriptor_name': 'Integrin alpha2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D039422', 'descriptor_name': 'Integrin alpha3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019012', 'descriptor_name': 'Integrin beta1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009361', 'descriptor_name': 'Neoplasm Invasiveness', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1242/jcs.02738', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S5677253', 'display_name': 'Journal of Cell Science', 'issn_l': '0021-9533', 'issn': ['0021-9533', '1477-9137'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'http://jcs.biologists.org/cgi/content/short/119/2/283', 'pdf_url': 'http://jcs.biologists.org/content/119/2/283.full.pdf', 'source': {'id': 'https://openalex.org/S128516502', 'display_name': 'Notes and Queries', 'issn_l': '0029-3970', 'issn': ['0029-3970', '1471-6941'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16390868', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'http://jcs.biologists.org/cgi/content/short/119/2/283', 'pdf_url': 'http://jcs.biologists.org/content/119/2/283.full.pdf', 'source': {'id': 'https://openalex.org/S128516502', 'display_name': 'Notes and Queries', 'issn_l': '0029-3970', 'issn': ['0029-3970', '1471-6941'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.6, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 38, 'referenced_works': ['https://openalex.org/W1484020898', 'https://openalex.org/W1565639679', 'https://openalex.org/W1924355940', 'https://openalex.org/W1963861194', 'https://openalex.org/W1967120404', 'https://openalex.org/W1967532587', 'https://openalex.org/W1982244057', 'https://openalex.org/W1983426119', 'https://openalex.org/W1988081415', 'https://openalex.org/W1990798651', 'https://openalex.org/W1995044247', 'https://openalex.org/W1997700910', 'https://openalex.org/W2001901914', 'https://openalex.org/W2002607915', 'https://openalex.org/W2007062957', 'https://openalex.org/W2010069724', 'https://openalex.org/W2010414816', 'https://openalex.org/W2038108689', 'https://openalex.org/W2054551243', 'https://openalex.org/W2069440750', 'https://openalex.org/W2086641174', 'https://openalex.org/W2087367170', 'https://openalex.org/W2097601945', 'https://openalex.org/W2124559417', 'https://openalex.org/W2128270057', 'https://openalex.org/W2135761150', 'https://openalex.org/W2136819289', 'https://openalex.org/W2137022580', 'https://openalex.org/W2138523931', 'https://openalex.org/W2147865927', 'https://openalex.org/W2152708430', 'https://openalex.org/W2160926271', 'https://openalex.org/W2165022280', 'https://openalex.org/W2166435080', 'https://openalex.org/W2172233194', 'https://openalex.org/W2189426703', 'https://openalex.org/W2411533639', 'https://openalex.org/W2764866906'], 'related_works': ['https://openalex.org/W2517195827', 'https://openalex.org/W2395439073', 'https://openalex.org/W2144977670', 'https://openalex.org/W2138835758', 'https://openalex.org/W2089368828', 'https://openalex.org/W2068374025', 'https://openalex.org/W2046958844', 'https://openalex.org/W2023618495', 'https://openalex.org/W1966355046', 'https://openalex.org/W163320466'], 'abstract_inverted_index': {'Much': [0], 'remains': [1], 'to': [2, 13, 34, 44, 84, 130, 144, 163, 179, 187, 206], 'be': [3], 'learned': [4], 'about': [5], 'how': [6, 37], 'cell-cell': [7, 193], 'and': [8, 72, 95, 138, 141, 146, 149, 194, 197], 'cell-matrix': [9, 195], 'interactions': [10], 'are': [11], 'coordinated': [12], 'influence': [14], 'the': [15, 103, 169, 188, 202], 'earliest': [16], 'development': [17], 'of': [18, 39, 53, 125, 135, 181, 192, 204], 'neoplasia.': [19], 'We': [20, 47], 'used': [21, 48], 'novel': [22, 177], '3D': [23, 79], 'human': [24, 55, 70], 'tissue': [25], 'reconstructs': [26], 'that': [27, 99, 152, 159, 184], 'mimic': [28], 'premalignant': [29], 'disease': [30], 'in': [31, 78, 91, 121], 'normal': [32, 69], 'epidermis,': [33], 'directly': [35], 'investigate': [36], 'loss': [38, 180], 'E-cadherin': [40, 60, 182], 'function': [41, 183], 'directs': [42], 'conversion': [43, 203], 'malignant': [45], 'disease.': [46], 'a': [49, 176], 'genetically': [50], 'tagged': [51], 'variant': [52], 'Ha-Ras-transformed': [54], 'keratinocytes': [56, 71], '(II-4)': [57], 'expressing': [58], 'dominant-interfering': [59], 'fusion': [61], 'protein': [62], '(H-2kd-Ecad).': [63], 'These': [64], 'cells': [65, 98, 109], 'were': [66], 'admixed': [67], 'with': [68, 102, 155], 'tumor': [73, 117], 'cell': [74, 118, 132, 166], 'fate': [75], 'was': [76, 89, 128, 153, 161], 'monitored': [77], 'reconstructed': [80], 'epidermis': [81], 'upon': [82, 120], 'transplantation': [83], 'immunodeficient': [85], 'mice.': [86], 'Tumor': [87], 'initiation': [88], 'suppressed': [90], 'tissues': [92], 'harboring': [93], 'control-': [94], 'mock-infected': [96], 'II-4': [97, 165], 'lost': [100], 'contact': [101], 'stromal': [104, 170], 'interface.': [105, 171], 'By': [106], 'contrast,': [107], 'H-2kd-Ecad-expressing': [108], 'persisted': [110], 'at': [111, 168], 'this': [112], 'interface,': [113], 'thus': [114], 'enabling': [115], 'incipient': [116], 'invasion': [119, 160], 'vivo': [122], 'transplantation.': [123], 'Loss': [124], 'intercellular': [126], 'adhesion': [127, 143, 196], 'linked': [129, 162, 186], 'elevated': [131], 'surface': [133], 'expression': [134], 'α2,': [136], 'α3': [137], 'β1': [139], 'integrins': [140], 'increased': [142], 'laminin-1': [145], 'Types': [147], 'I': [148], 'IV': [150], 'collagen': [151], 'blocked': [154], 'β1-integrin': [156], 'antibodies,': [157], 'suggesting': [158], 'initial': [164], 'attachment': [167], 'Collectively,': [172], 'these': [173], 'results': [174], 'outline': [175], 'aspect': [178], 'is': [185], 'mutually': [189], 'interdependent': [190], 'regulation': [191], 'has': [198], 'significant': [199], 'consequences': [200], 'for': [201], 'premalignancy': [205], 'cancer.': [207]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2124261208', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-09-19T18:11:13.935078', 'created_date': '2016-06-24'}