Publication Information

{'id': 'https://openalex.org/W2124217674', 'doi': 'https://doi.org/10.1128/jvi.65.9.4887-4892.1991', 'title': 'Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors', 'display_name': 'Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors', 'publication_year': 1991, 'publication_date': '1991-09-01', 'ids': {'openalex': 'https://openalex.org/W2124217674', 'doi': 'https://doi.org/10.1128/jvi.65.9.4887-4892.1991', 'mag': '2124217674', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/1714522', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/248949'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/jvi.65.9.4887-4892.1991', 'pdf_url': 'https://jvi.asm.org/content/jvi/65/9/4887.full.pdf', 'source': {'id': 'https://openalex.org/S96615428', 'display_name': 'Journal of Virology', 'issn_l': '0022-538X', 'issn': ['0022-538X', '1070-6321', '1098-5514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://jvi.asm.org/content/jvi/65/9/4887.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5072936149', 'display_name': 'Jack H. Nunberg', 'orcid': 'https://orcid.org/0000-0003-1270-768X'}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J H Nunberg', 'raw_affiliation_strings': ['Department of Virus and Cell Biology, Merck, Sharp, and Dohme Research Laboratories, West Point, Pennsylvania 19486.'], 'affiliations': [{'raw_affiliation_string': 'Department of Virus and Cell Biology, Merck, Sharp, and Dohme Research Laboratories, West Point, Pennsylvania 19486.', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030101432', 'display_name': 'William A. Schleif', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'W A Schleif', 'raw_affiliation_strings': ['Department of Virus and Cell Biology, Merck, Sharp, and Dohme Research Laboratories, West Point, Pennsylvania 19486.'], 'affiliations': [{'raw_affiliation_string': 'Department of Virus and Cell Biology, Merck, Sharp, and Dohme Research Laboratories, West Point, Pennsylvania 19486.', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005922995', 'display_name': 'Evelyn Boots', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'E J Boots', 'raw_affiliation_strings': ['Department of Virus and Cell Biology, Merck, Sharp, and Dohme Research Laboratories, West Point, Pennsylvania 19486.'], 'affiliations': [{'raw_affiliation_string': 'Department of Virus and Cell Biology, Merck, Sharp, and Dohme Research Laboratories, West Point, Pennsylvania 19486.', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101621868', 'display_name': "J A O'Brien", 'orcid': 'https://orcid.org/0000-0001-5305-4350'}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': "J A O'Brien", 'raw_affiliation_strings': ['Department of Virus and Cell Biology, Merck, Sharp, and Dohme Research Laboratories, West Point, Pennsylvania 19486.'], 'affiliations': [{'raw_affiliation_string': 'Department of Virus and Cell Biology, Merck, Sharp, and Dohme Research Laboratories, West Point, Pennsylvania 19486.', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039250623', 'display_name': 'J C Quintero', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J C Quintero', 'raw_affiliation_strings': ['Department of Virus and Cell Biology, Merck, Sharp, and Dohme Research Laboratories, West Point, Pennsylvania 19486.'], 'affiliations': [{'raw_affiliation_string': 'Department of Virus and Cell Biology, Merck, Sharp, and Dohme Research Laboratories, West Point, Pennsylvania 19486.', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038873861', 'display_name': 'J. M. HOFFMAN', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J M Hoffman', 'raw_affiliation_strings': ['Department of Virus and Cell Biology, Merck, Sharp, and Dohme Research Laboratories, West Point, Pennsylvania 19486.'], 'affiliations': [{'raw_affiliation_string': 'Department of Virus and Cell Biology, Merck, Sharp, and Dohme Research Laboratories, West Point, Pennsylvania 19486.', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020211730', 'display_name': 'Emilio A. Emini', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'E A Emini', 'raw_affiliation_strings': ['Department of Virus and Cell Biology, Merck, Sharp, and Dohme Research Laboratories, West Point, Pennsylvania 19486.'], 'affiliations': [{'raw_affiliation_string': 'Department of Virus and Cell Biology, Merck, Sharp, and Dohme Research Laboratories, West Point, Pennsylvania 19486.', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5050717269', 'display_name': 'Mark E. Goldman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'M E Goldman', 'raw_affiliation_strings': ['Department of Virus and Cell Biology, Merck, Sharp, and Dohme Research Laboratories, West Point, Pennsylvania 19486.'], 'affiliations': [{'raw_affiliation_string': 'Department of Virus and Cell Biology, Merck, Sharp, and Dohme Research Laboratories, West Point, Pennsylvania 19486.', 'institution_ids': ['https://openalex.org/I1285764155']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 13.989, 'has_fulltext': False, 'cited_by_count': 366, 'citation_normalized_percentile': {'value': 0.922282, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '65', 'issue': '9', 'first_page': '4887', 'last_page': '4892'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10112', 'display_name': 'HIV Research and Treatment', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2406', 'display_name': 'Virology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10112', 'display_name': 'HIV Research and Treatment', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2406', 'display_name': 'Virology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10526', 'display_name': 'HIV/AIDS drug development and treatment', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10082', 'display_name': 'HIV/AIDS Research and Interventions', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/resistance-mutation', 'display_name': 'Resistance mutation', 'score': 0.5362987}, {'id': 'https://openalex.org/keywords/serial-passage', 'display_name': 'Serial passage', 'score': 0.50768673}], 'concepts': [{'id': 'https://openalex.org/C156719811', 'wikidata': 'https://www.wikidata.org/wiki/Q28774', 'display_name': 'Reverse transcriptase', 'level': 4, 'score': 0.82738733}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.81887954}, {'id': 'https://openalex.org/C2776543447', 'wikidata': 'https://www.wikidata.org/wiki/Q28734', 'display_name': 'Nucleoside', 'level': 2, 'score': 0.5726703}, {'id': 'https://openalex.org/C182707283', 'wikidata': 'https://www.wikidata.org/wiki/Q7315622', 'display_name': 'Resistance mutation', 'level': 5, 'score': 0.5362987}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.5134357}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.5125005}, {'id': 'https://openalex.org/C132351222', 'wikidata': 'https://www.wikidata.org/wiki/Q7454699', 'display_name': 'Serial passage', 'level': 3, 'score': 0.50768673}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.49409083}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.4895926}, {'id': 'https://openalex.org/C82381507', 'wikidata': 'https://www.wikidata.org/wiki/Q416878', 'display_name': 'Polymerase', 'level': 3, 'score': 0.48936433}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.48456016}, {'id': 'https://openalex.org/C153574943', 'wikidata': 'https://www.wikidata.org/wiki/Q408939', 'display_name': 'Nucleotidyltransferase', 'level': 4, 'score': 0.4499928}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.43194452}, {'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.41866142}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.41592437}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.338534}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.25162992}], 'mesh': [{'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D001583', 'descriptor_name': 'Benzoxazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D015497', 'descriptor_name': 'HIV-1', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D011728', 'descriptor_name': 'Pyridones', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D018894', 'descriptor_name': 'Reverse Transcriptase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001583', 'descriptor_name': 'Benzoxazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003001', 'descriptor_name': 'Cloning, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004352', 'descriptor_name': 'Drug Resistance, Microbial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015497', 'descriptor_name': 'HIV-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015497', 'descriptor_name': 'HIV-1', 'qualifier_ui': 'Q000254', 'qualifier_name': 'growth & development', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054833', 'descriptor_name': 'Isoindoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009841', 'descriptor_name': 'Oligonucleotides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009841', 'descriptor_name': 'Oligonucleotides', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011728', 'descriptor_name': 'Pyridones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012194', 'descriptor_name': 'RNA-Directed DNA Polymerase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012194', 'descriptor_name': 'RNA-Directed DNA Polymerase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012194', 'descriptor_name': 'RNA-Directed DNA Polymerase', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014779', 'descriptor_name': 'Virus Replication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014779', 'descriptor_name': 'Virus Replication', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/jvi.65.9.4887-4892.1991', 'pdf_url': 'https://jvi.asm.org/content/jvi/65/9/4887.full.pdf', 'source': {'id': 'https://openalex.org/S96615428', 'display_name': 'Journal of Virology', 'issn_l': '0022-538X', 'issn': ['0022-538X', '1070-6321', '1098-5514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc248949', 'pdf_url': 'https://europepmc.org/articles/pmc248949?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC248949', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/1714522', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/jvi.65.9.4887-4892.1991', 'pdf_url': 'https://jvi.asm.org/content/jvi/65/9/4887.full.pdf', 'source': {'id': 'https://openalex.org/S96615428', 'display_name': 'Journal of Virology', 'issn_l': '0022-538X', 'issn': ['0022-538X', '1070-6321', '1098-5514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.83, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 36, 'referenced_works': ['https://openalex.org/W1564941168', 'https://openalex.org/W1580337971', 'https://openalex.org/W1659719610', 'https://openalex.org/W1926094917', 'https://openalex.org/W1965372133', 'https://openalex.org/W1968873679', 'https://openalex.org/W1971143006', 'https://openalex.org/W1974261771', 'https://openalex.org/W1977282539', 'https://openalex.org/W1979140780', 'https://openalex.org/W1984298556', 'https://openalex.org/W1991670386', 'https://openalex.org/W1994270788', 'https://openalex.org/W2015791742', 'https://openalex.org/W2018893626', 'https://openalex.org/W2032118018', 'https://openalex.org/W2032737565', 'https://openalex.org/W2036196796', 'https://openalex.org/W2046134251', 'https://openalex.org/W2052306401', 'https://openalex.org/W2056686421', 'https://openalex.org/W2058350611', 'https://openalex.org/W2065114401', 'https://openalex.org/W2067786897', 'https://openalex.org/W2071313281', 'https://openalex.org/W2086462809', 'https://openalex.org/W2095433332', 'https://openalex.org/W2108643864', 'https://openalex.org/W2116464980', 'https://openalex.org/W2138270253', 'https://openalex.org/W2144634347', 'https://openalex.org/W2146398256', 'https://openalex.org/W2167716173', 'https://openalex.org/W2327723086', 'https://openalex.org/W2333399282', 'https://openalex.org/W2405883704'], 'related_works': ['https://openalex.org/W4280620613', 'https://openalex.org/W2801690562', 'https://openalex.org/W2355732708', 'https://openalex.org/W2148784233', 'https://openalex.org/W2115030358', 'https://openalex.org/W2106142539', 'https://openalex.org/W2097059709', 'https://openalex.org/W2066557443', 'https://openalex.org/W2045696382', 'https://openalex.org/W2017028114'], 'abstract_inverted_index': {'Human': [0], 'immunodeficiency': [1], 'virus': [2, 132], 'type': [3], '1': [4], '(HIV-1)-specific': [5], 'pyridinone': [6, 113], 'reverse': [7], 'transcriptase': [8], '(RT)': [9], 'inhibitors': [10, 229, 320], 'prevent': [11], 'HIV-1': [12, 120], 'replication': [13], 'in': [14, 121, 126, 189, 211], 'cell': [15, 122], 'culture': [16], '(M.': [17], 'E.': [18, 52, 261], 'Goldman,': [19], 'J.': [20, 23, 40, 43, 50, 236, 241, 244, 248, 253, 267, 276, 287, 296, 304, 310], 'H.': [21, 243], 'Nunberg,': [22], 'A.': [24, 29, 53, 56, 246, 258, 266, 298, 307], "O'Brien,": [25], 'J.C.': [26], 'Quintero,': [27], 'W.': [28, 37], 'Schleif,': [30], 'K.': [31, 234, 255, 278, 283, 292], 'F.': [32], 'Freund,': [33], 'S.': [34, 38, 41, 47, 294, 299], 'L.': [35, 311], 'Gaul,': [36], 'Saari,': [39], 'Wai,': [42], 'M.': [44, 57, 240, 257, 281, 285], 'Hoffman,': [45], 'P.': [46, 265], 'Anderson,': [48], 'D.': [49, 238, 279], 'Hupe,': [51], 'Emini,': [54], 'and': [55, 165, 192, 264, 273, 309, 329], 'Stern,': [58], 'Proc.': [59], 'Natl.': [60], 'Acad.': [61], 'Sci.': [62], 'USA': [63], '88:6863-6867,': [64], '1991).': [65], 'In': [66], 'contrast': [67], 'to': [68, 77, 80, 89, 100, 106, 137, 163, 167, 183, 219, 224], 'nucleoside': [69, 220], 'analog': [70, 319], 'inhibitors,': [71, 114], 'such': [72], 'as': [73], 'AZT,': [74], 'which': [75, 95, 133, 171, 207], 'need': [76], 'be': [78, 209], 'converted': [79], 'triphosphates': [81], 'by': [82], 'host': [83], 'cells,': [84], 'these': [85, 317, 352], 'compounds': [86, 138], 'act': [87], 'directly': [88], 'inhibit': [90], 'RT': [91, 155, 206, 228, 328, 339], 'via': [92], 'a': [93, 203, 323, 334], 'mechanism': [94, 109], 'is': [96], 'noncompetitive': [97], 'with': [98], 'respect': [99], 'deoxynucleoside': [101], 'triphosphates.': [102], 'As': [103], 'one': [104], 'approach': [105], 'define': [107], 'the': [108, 127, 184, 225, 348], 'of': [110, 112, 119, 129, 139, 170, 205, 338, 351], 'action': [111], 'we': [115], 'isolated': [116], 'resistant': [117, 136, 148, 154, 215], 'mutants': [118], 'culture.': [123], 'Serial': [124], 'passage': [125], 'presence': [128], 'inhibitor': [130], 'yielded': [131], 'was': [134], '1,000-fold': [135], 'this': [140], 'class.': [141], 'Bacterially': [142], 'expressed': [143], 'RTs': [144], 'molecularly': [145], 'cloned': [146], 'from': [147], 'viruses': [149], 'were': [150, 222], 'also': [151], 'resistant.': [152], 'The': [153, 175, 195, 214], 'genes': [156], 'encoded': [157], 'two': [158], 'amino': [159, 178, 198], 'acid': [160, 179, 199], 'changes,': [161], 'K-103': [162], 'N': [164], 'Y-181': [166], 'C,': [168], 'each': [169], 'contributed': [172], 'partial': [173], 'resistance.': [174], 'mutation': [176, 196], 'at': [177, 197], '181': [180], 'lies': [181, 201], 'adjacent': [182], 'conserved': [185], 'YG/MDD': [186], 'motif': [187], 'found': [188], 'most': [190], 'DNA': [191], 'RNA': [193], 'polymerases.': [194], '103': [200], 'within': [202], 'region': [204], 'may': [208, 321, 330, 343], 'involved': [210], 'PPi': [212], 'binding.': [213], 'viruses,': [216], 'although': [217], 'sensitive': [218], 'analogs,': [221], 'cross-resistant': [223], 'structurally': [226], 'unrelated': [227], 'TIBO': [230], 'R82150': [231], '(R.': [232], 'Pauwels,': [233], 'Andries,': [235], 'Desmyter,': [237], 'Schols,': [239], 'Kukla,': [242], 'Breslin,': [245], 'Raeymaeckers,': [247], 'Van': [249], 'Gelder,': [250], 'R.': [251, 301, 303, 306], 'Woestenborghs,': [252], 'Heykanti,': [254], 'Schellekens,': [256], 'C.': [259, 288], 'Janssen,': [260, 268], 'De': [262], 'Clercq,': [263], 'Nature': [269], '[London]': [270], '343:470-474,': [271], '1990)': [272], 'BI-RG-587': [274], '(V.': [275], 'Merluzzi,': [277], 'Hargrave,': [280], 'Labadia,': [282], 'Grozinger,': [284], 'Skoog,': [286], 'Wu,': [289], 'C.-K.': [290], 'Shih,': [291], 'Eckner,': [293, 305], 'Hattox,': [295], 'Adams,': [297], 'Rosenthal,': [300], 'Faanes,': [302], 'Koup,': [308], 'Sullivan,': [312], 'Science': [313], '250:1411-1413,': [314], '1990).': [315], 'Thus,': [316], 'nonnucleoside': [318], 'share': [322], 'common': [324], 'binding': [325], 'site': [326], 'on': [327], 'all': [331], 'make': [332], 'up': [333], 'single': [335], 'pharmacologic': [336], 'class': [337], 'inhibitor.': [340], 'This': [341], 'observation': [342], 'have': [344], 'important': [345], 'implications': [346], 'for': [347], 'clinical': [349], 'development': [350], 'compounds.': [353]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2124217674', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-10T05:43:16.521228', 'created_date': '2016-06-24'}