Mitotic Arrest, Apoptosis, and Sensitization to Chemotherapy of Melanomas by Methionine Deprivation Stress

Name: Work Video:
Duration: 3 min 30 s
Demetrius M. Kokkinakis; Anthony G. Brickner; John M. Kirkwood; Xiaoyan Liu; Jason E. Goldwasser; Anastasiya Kastrama; Cindy Sander; Dora Bocangel; Sunil Chada
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232], 'has': [20], 'a': [21, 52, 155, 197, 202], 'negligible': [22], 'effect': [23], 'on': [24], 'normal': [25, 160], 'skin': [26, 161], 'fibroblasts.': [27], 'In': [28], 'most': [29], 'cases,': [30], 'apoptosis': [31, 222], 'accounts': [32], 'for': [33, 129], 'the': [34, 44, 99, 136, 166, 206, 216, 241, 257, 266], 'elimination': [35], 'up': [37], 'to': [38, 116, 149, 154, 175, 188, 225], '90%': [39], 'tumor': [41, 63, 244], 'from': [43], 'culture': [45], 'within': [46], '72': [47], 'hours': [48], 'after': [49], 'MDS,': [50], 'leaving': [51], 'scattered': [53], 'population': [54], 'multinucleated': [56, 140], 'resistant': [57], 'cells.': [58, 141], 'Loss': [59, 119], 'mitosis': [61], 'is': [65, 84, 110, 133, 201, 233, 238], 'associated': [66, 134, 209], 'with': [67, 86, 135, 210], 'marked': [68], 'reduction': [69], 'cyclin-dependent': [71], 'kinase': [72, 122], '(CDK)': [73], '1': [74], 'transcription': [75], 'and/or': [76, 221], 'loss': [77, 189], 'its': [79], 'active': [80], 'form': 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'possibly': [163], 'because': [164], 'suppression': [167], 'MGMT/TOP1/POLB,': [169], 'MGMT/RAD52/RAD54,': [170], 'cMET/RADD52,': [172], 'respectively.': [173], 'Sensitivity': [174], 'these': [176], 'additional': [178], 'genotoxic': [179], 'agents': [180], 'radiation': [182], 'may': [183, 291], 'also': [184], 'be': [185, 300], 'acquired': [186], 'due': [187], 'cMET/OGG1,': [191], 'reduced': [192], 'glutathione': [193], 'reductase': [194], 'levels,': [195], 'G2-phase': [198], 'block': [199], 'that': [200, 235], 'crucial': [203], 'step': [204], 'damage': [207], 'response': [208, 224], 'enhancement': [211], 'drug': [213], 'toxicity.': [214], 'Although': [215, 279], 'genes': [217, 284], 'controlling': [218], 'arrest': [220], 'low': [226], 'extracellular': [227], 'methionine': [228], 'levels': [229], 'unknown,': [231], 'likely': [234], 'such': [236, 248, 273], 'control': [237], 'exerted': [239], 'via': [240], 'induction/up-regulation': [242], 'suppressors/growth': [245], 'inhibitor': [246], 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